The University of Nottingham

United Kingdom

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A61P 35/00 - Antineoplastic agents 17
A61B 5/00 - Measuring for diagnostic purposes Identification of persons 14
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca 11
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor 9
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof 8
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1.

STABILISED COPPER PARTICLES

      
Application Number GB2024051965
Publication Number 2025/022126
Status In Force
Filing Date 2024-07-26
Publication Date 2025-01-30
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Pereira, Jessica
  • Newton, Graham
  • Amabilino, David
  • Makarovsky, Oleg

Abstract

Stabilised copper sub-micron scale particles are provided, which are suitable for use in the manufacture of an electrically conductive product. The particles have a mean diameter in the range of from 25nm to 1000nm, and each particle comprises (a) a metallic copper inner core and (b) a sulfated polymer outer layer. The particles can be compressed at room temperature to fabricate free-standing conductive copper films or can be deposited onto a substrate to form supported electrically conductive products.

IPC Classes  ?

  • H01B 1/02 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of metals or alloys

2.

MACHINE LEARNING MODEL ASSESSMENT

      
Application Number EP2024069566
Publication Number 2025/012347
Status In Force
Filing Date 2024-07-10
Publication Date 2025-01-16
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Chen, Yan

Abstract

Disclosed herein is a computer-implemented method which comprises obtaining testing data comprising a plurality of medical images and at least one likelihood value associated with each image. The likelihood values have been assigned by a machine learning model. Each likelihood value is indicative of a likelihood that a feature in the associated image is a malignant feature. The method further comprises determining a first classification data set for the plurality of images by comparing, for each image, the at least one likelihood value to a decision threshold; comparing the first classification data set to a verified classification data set associated with the plurality of medical images; and determining, based on comparing the first classification data set to the verified classification data set, a performance score associated with the machine learning model.

IPC Classes  ?

  • G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
  • G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
  • G06V 10/776 - ValidationPerformance evaluation
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

3.

MATERIALS CHEMISTRIES AND MICROTOPOGRAPHIES AND USES THEREOF

      
Application Number 17799914
Status Pending
Filing Date 2021-02-15
First Publication Date 2024-11-21
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Alexander, Morgan
  • Ghaemmaghami, Amir
  • Williams, Paul
  • Avery, Simon
  • Hook, Andrew
  • Rose, Felicity
  • Denning, Chris

Abstract

A microtopography system for modulating one or more cellular processes on a surface is described. In particular a microtopography system comprising: a repeated microtopographic pattern and a polymer coating, said microtopographic pattern comprising: an array of repeated micropillars applied to a surface of a product, said micropillars being formed of surface structures between 1-100 μm in height, and 1-50 μm in width; and said polymer coating comprising one of a (meth)acrylate or (meth)acrylamide monomer, or mixture of two (meth)acrylate or (meth)acrylamide monomers. The microtopographic pattern and said polymer coating act to modulate one or more cellular processes on the surface.

IPC Classes  ?

  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
  • A61L 27/34 - Macromolecular materials
  • A61L 27/50 - Materials characterised by their function or physical properties
  • A61L 31/04 - Macromolecular materials
  • A61L 31/14 - Materials characterised by their function or physical properties

4.

DECELLULARIZED TISSUE HYDROGELS

      
Application Number 18557561
Status Pending
Filing Date 2022-04-29
First Publication Date 2024-11-07
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • White, Lisa
  • Jones, Joshua

Abstract

The invention provides a decellularized tissue hydrogel cross-linked with a polyphenol, and a method of preparing a cross-linked decellularized tissue hydrogel, the method comprising the steps of: a) providing at least one decellularized tissue hydrogel; and b) cross-linking the at least one decellularized tissue hydrogel with a polyphenol.

IPC Classes  ?

  • A61L 27/52 - Hydrogels or hydrocolloids
  • A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof

5.

Sample Property Determination

      
Application Number 18684535
Status Pending
Filing Date 2022-08-09
First Publication Date 2024-10-31
Owner The University of Nottingham (United Kingdom)
Inventor
  • Clark, Matt
  • Dryburgh, Paul
  • Li, Wenqi
  • Smith, Richard

Abstract

A method of determining one or more properties of a sample, comprising: determining, at a plurality of generation sites of the sample, a plurality of acoustic velocity measurements, the plurality of acoustic velocity measurements using different acoustic propagation directions; and determining a best fit elasticity for the acoustic velocity measurements at different acoustic propagation directions at the plurality of generation sites, wherein determining a best fit elasticity comprises assuming a common elasticity for the plurality of generation sites while allowing crystallographic orientation to vary.

IPC Classes  ?

  • G01N 29/07 - Analysing solids by measuring propagation velocity or propagation time of acoustic waves
  • G01N 29/04 - Analysing solids
  • G01N 29/24 - Probes
  • G01N 29/44 - Processing the detected response signal

6.

NUCLEIC ACID MOLECULE AND METHODS

      
Application Number GB2024050904
Publication Number 2024/209201
Status In Force
Filing Date 2024-04-02
Publication Date 2024-10-10
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Humphreys, Christopher
  • Minton, Nigel

Abstract

The invention relates to a nucleic acid molecule encoding a group II intron, wherein the group II intron encodes a retrotransposition-activated marker (RAM) and a counter-selection marker. The invention further relates to a nucleic acid molecule encoding: a first promoter operably-linked to a group II intron, wherein the group II intron does not encode a protein comprising reverse transcriptase activity, and a second promoter operably-linked to a nucleic acid sequence encoding an intron-encoded protein (IEP), wherein the group II intron encodes: a retrotransposition-activated marker (RAM), a counter-selection marker, and a targeting sequence; and related kits and methods.

IPC Classes  ?

  • C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 15/90 - Stable introduction of foreign DNA into chromosome

7.

A MAGNETIC SHIELD

      
Application Number 18559627
Status Pending
Filing Date 2022-05-20
First Publication Date 2024-08-22
Owner
  • MAGNETIC SHIELDS LIMITED (United Kingdom)
  • UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Woolger, David
  • Chalmers, James
  • Farmer, Joseph
  • Dawson, Eliot
  • Bowtell, Richard
  • Brookes, Matthew
  • Holmes, Niall
  • Glover, Paul

Abstract

An active magnetic shield system, including an array of magnetic field sensors arranged to sense a local magnetic field. An array of magnetic field elements are arranged produce a magnetic field. Each magnetic field element has a unit coil for mounting to a plurality of surfaces arranged in at least 3 planes to define an enclosed cancellation volume, and to produce a vector magnetic field pattern.

IPC Classes  ?

  • G01R 33/421 - Screening of main or gradient magnetic field
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
  • A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
  • H05K 9/00 - Screening of apparatus or components against electric or magnetic fields

8.

REDOX NANOPARTICLE

      
Application Number GB2024050381
Publication Number 2024/170884
Status In Force
Filing Date 2024-02-13
Publication Date 2024-08-22
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Rawson, Frankie James
  • Jain, Akhil
  • Perez-Garcia, Lluisa
  • Amabilino, David

Abstract

The invention relates to conductive nanoparticles, comprising an electron donor species and an electron acceptor species each attached to the nanoparticle, and pharmaceutical compositions comprising such nanoparticles. The invention also relates to use of the nanoparticles in modulating the biological activity of one or more cells such as cancer cells, and in treating cancer.

IPC Classes  ?

  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
  • A61P 35/00 - Antineoplastic agents

9.

WIND TURBINE WITH INTEGRAL ENERGY STORAGE USES ROTARY HEAT EXCHANGERS TO ACCOMMODATE NACELLE YAW

      
Application Number GB2024050261
Publication Number 2024/165832
Status In Force
Filing Date 2024-01-30
Publication Date 2024-08-15
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Garvey, Seamus

Abstract

A wind turbine may be fitted with the facility store electricity indirectly using one or more thermal stores. The power-conversion machinery is installed within the wind turbine nacelle which rotates to point the turbine into the wind. The thermal storage is realised in the fixed frame – i.e. it does not rotate with the nacelle. The connection between the fixed frame and the rotatable frame is via one or more rotary heat exchangers. While the energy storage is charging, heat passes through the hot heat exchanger to a hot store or coldness passes through the cold heat exchanger to a cold store or both. During discharging, the opposite flows occur. Each rotary heat exchanger has a shell-and-tube configuration. The tube bundle rotates with the nacelle. The shell comprises one set of surfaces that does not rotate and one that does rotate.

IPC Classes  ?

  • F03D 80/60 - Cooling or heating of wind motors
  • F03D 80/80 - Arrangement of components within nacelles or towers

10.

HAT AND MONITORING SYSTEM

      
Application Number 18605335
Status Pending
Filing Date 2024-03-14
First Publication Date 2024-08-01
Owner
  • SUREPULSE MEDICAL LIMITED (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Carpenter, James
  • Hayes-Gill, Barrie
  • Henry, Caroline
  • Sharkey, Don
  • Shipley, Lara

Abstract

A hat (200) for a neonate (120) comprising: a central portion (201), a first side portion (202) and second side portion (203) attached to opposite sides of the central portion (201), a first fastener (208); a top flap (204) and a second fastener (211). The hat (200) has an unfolded configuration and a worn configuration. In the unfolded configuration the first and second portions (202, 203) extend away from each other from the central portion (201) in opposite directions. In the worn configuration the hat (200) wraps a neonate's head with the central portion (201) in contact with the back of the neonate's head, the first portion (202) wrapped around a first side of the neonate's head and the second portion (203) wrapped around a second side of the neonate's head. The first and second portions (202, 203) are configured to be fastened together in the worn configuration by the first fastener (208) so that the first portion (202), central portion (201) and second portion (203) together define a hat (214) rim encircling the neonate's head. The top flap (204) is configured to cover the top of the neonate's head in the worn configuration. The top flap (204) is configured to be fastened to at least one of the first, central and second portions (202, 201, 203) by the second fastener (211). The hat (200) further comprises an optical physiological sensor that comprises: a flexible circuit board, a light emitter (310) and a light detector (311); the flexible circuit board having: a sensor portion (302) to which the light emitter (310) and light detector (311) are connected; a module portion (305) including contacts (304) for electrically connecting the light emitter (310) and light detector (311) to a removable readout module (400); and an elongate lead portion (301) between the sensor portion (302) and module portion (305).

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]

11.

SORBENTS FOR CARBON DIOXIDE CAPTURE

      
Application Number EP2023086718
Publication Number 2024/133317
Status In Force
Filing Date 2023-12-19
Publication Date 2024-06-27
Owner
  • BASF SE (Germany)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
  • PQ SILICAS UK LIMITED (United Kingdom)
Inventor
  • Hueffer, Stephen
  • Garcia Castro, Ivette
  • Merkel, Tobias Maximilian
  • Stevens, Lee Anthony
  • Snape, Colin Edward
  • Stebbing, Simon Richard
  • Li, Wei

Abstract

Sorbents for carbon dioxide capture The present invention provides a sorbent for absorbing carbon dioxide from a gas or a mixture of gases comprising: (A) polyalkyleneimine or an alkoxylated polyalkyleneimine; and (B) an inorganic solid support for the polyalkyleneimine or alkoxylated polyalkyleneimine (A), in which the alkoxylated polyalkyleneimine (A) is located on the inorganic solid support (B), wherein the sorbent comprises water in an amount of greater than 2 wt. % based on the weight of the sorbent. The present invention also provides a process for preparing such a sorbent and additionally provides uses of the sorbent for capturing carbon dioxide from a mixture of gases, such as air.

IPC Classes  ?

  • B01J 20/32 - Impregnating or coating
  • B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
  • B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
  • B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography

12.

THIOCARBONYLTHIO COMPOUNDS AND BATTERIES

      
Application Number GB2023053177
Publication Number 2024/126986
Status In Force
Filing Date 2023-12-08
Publication Date 2024-06-20
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Kibler, Alexander
  • Searle, Joanne
  • Newton, Graham
  • Walsh, Darren
  • Johnson, Lee

Abstract

11010 alkyl group; an aryl group optionally substituted with at least one moiety selected from the group comprising: a halogen, a hydroxy group, a nitro group, an alkyl group, an alkoxy group or a nitrile group; an optionally substituted amine; an alkoxy group; an aryloxy group or a thio group, R1is hydrogen, an aryl group or an alkyl group, R2is hydrogen, an aryl group or an alkyl group, and R3is an aryl group, a nitrile group, a COOR4group or an OCOR4group, wherein R4 is an alkyl group.

IPC Classes  ?

  • H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
  • H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
  • H01M 10/0567 - Liquid materials characterised by the additives
  • C07C 327/36 - Esters of dithiocarboxylic acids

13.

POLYOXOMETALATE COMPOUNDS AND BATTERIES

      
Application Number GB2023053176
Publication Number 2024/126985
Status In Force
Filing Date 2023-12-08
Publication Date 2024-06-20
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Kibler, Alexander
  • Newton, Graham
  • Walsh, Darren
  • Johnson, Lee

Abstract

The invention provides a lithium-sulfur battery comprising a positive electrode, a negative electrode and an electrolyte wherein the electrolyte comprises a solvent and at least one polyoxometalate compound wherein the at least one polyoxometalate compound is dissolved in the solvent.

IPC Classes  ?

  • H01M 10/0567 - Liquid materials characterised by the additives
  • H01M 10/052 - Li-accumulators
  • H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
  • H01M 10/0568 - Liquid materials characterised by the solutes
  • H01M 10/0569 - Liquid materials characterised by the solvents

14.

BIOSYNTHESIS OF PLASTICS PRECURSORS

      
Application Number GB2023053015
Publication Number 2024/105408
Status In Force
Filing Date 2023-11-16
Publication Date 2024-05-23
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Bryan, Samantha
  • Spence, Edward
  • Reitzer, Pierre
  • Pordea, Anca
  • Croft, Anna
  • Conradie, Alex

Abstract

The invention provides a method for the preparation of 5-hydroxymethylfurfural or a derivative thereof and 2,5-furandicarboxylic acid comprising the step of biocatalytically converting at least one carbonaceous feedstock supplemented with glucose to 5-hydroxymethylfurfural or a derivative thereof and 2,5-furandicarboxylic acid also via intermediates like glyceraldehyde-3-phosphate and 4-hydroxymethyl-2-furancarboxaldehyde-phosphate using Streptomyces sp. S deposited as NCIMB 43995 and gene MfnB encoding (5-fromylfuran-3-yl)methyl phosphate synthase (EC 4.2.3.153) isolated from said strain.

IPC Classes  ?

15.

ALKOXYLATED POLYALKYLENEIMINES, PREPARATION AND USE

      
Application Number EP2023079123
Publication Number 2024/104700
Status In Force
Filing Date 2023-10-19
Publication Date 2024-05-23
Owner
  • BASF SE (Germany)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Hueffer, Stephan
  • Garcia Castro, Ivette
  • Merkel, Tobias Maximilian
  • Stevens, Lee Anthony
  • Snape, Colin Edward

Abstract

A process for producing compositions comprising alkoxylated polyalkyleneimines, said compositions and their uses The present invention provides the use of a composition comprising alkoxylated polyalkyleneimine for capturing gases with a pKa greater than 5, preferably carbon dioxide, from a gas or mixture of gases, the composition being obtainable by a process for producing a composition comprising an alkoxylated polyalkyleneimine comprising the steps: (a) providing a reaction mixture comprising (i) a polyalkyleneimine; and (ii) an alkylene oxide; (b) carrying out a reaction between the (i) polyalkyleneimine and the (ii) alkylene oxide at a temperature of at least 50°C; and (c) optionally diluting the product of step (b), wherein the mole ratio of alkylene oxide to NH of the polyalkyleneimine in the reaction mixture is from 0.1 to 0.35, and wherein the reaction mixture comprises <55% water, preferably <30% water, based on the weight of the reaction mixture and the reaction mixture comprises less than 5%, preferably less than 1 %, of a polar organic solvent based on the weight of the reaction mixture. The invention also claims a new composition comprising an alkoxylated polyalkyleneimine, which is obtainable by the analogous process as above, in whichthe alkylene oxide comprises propylene oxide and/or butylene oxide. The process of producing the new composition is also claimed. The new composition has been found to be effective at capturing carbon dioxide from a mixture of gases, e.g. air.

IPC Classes  ?

  • B01D 53/00 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols
  • B01D 53/62 - Carbon oxides
  • C08G 73/02 - Polyamines
  • B01J 20/26 - Synthetic macromolecular compounds

16.

SUBSTITUTED BICYCLIC DIENES

      
Application Number GB2023052728
Publication Number 2024/084227
Status In Force
Filing Date 2023-10-20
Publication Date 2024-04-25
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Woodward, Simon
  • Lam, Hon Wai
  • Rit, Raja Kumar

Abstract

The invention provides a chiral single stereoisomer diene of Formula (I) wherein R1, R2, and R3are each substituent groups that are independently selected from H, halogen groups, alkyl groups (which may be linear or branched), alkenyl groups (which may be linear or branched, and may in particular be allyl or methallyl), aryl groups, alkaryl groups, heteroaryl groups, and substituted amino groups, ether groups, or carbonyl groups; wherein each substituent group R may be optionally substituted; and wherein R1, R2, and R3HH)-one ligands according to the present invention may be used as ligands for metals in enantioselective catalysis and transition metal complexes of these ligands may in particular be used as catalyst in the manufacture of active pharmaceutical ingredients.

IPC Classes  ?

  • C07D 209/96 - Spiro-condensed ring systems
  • C07B 63/00 - PurificationSeparation specially adapted for the purpose of recovering organic compoundsStabilisationUse of additives

17.

VEGF ANTIBODIES

      
Application Number GB2023052666
Publication Number 2024/079482
Status In Force
Filing Date 2023-10-13
Publication Date 2024-04-18
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Bates, David

Abstract

165165b antibodies. The invention also relates to pharmaceutical compositions, kits and methods of use in therapy.

IPC Classes  ?

  • C07K 16/22 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors
  • A61P 35/00 - Antineoplastic agents
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

18.

ANTIVIRAL COMPOUNDS AND METHODS

      
Application Number 17768003
Status Pending
Filing Date 2020-10-07
First Publication Date 2024-04-11
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Chang, Kin-Chow
  • Hayes, Christopher James
  • Gershkovich, Pavel

Abstract

The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) or (Ia) wherein R1-R4, A and B are as defined herein. Also provided are pharmaceutical compositions and combinations comprising such agents. The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) or (Ia) wherein R1-R4, A and B are as defined herein. Also provided are pharmaceutical compositions and combinations comprising such agents.

IPC Classes  ?

  • C07D 307/93 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/365 - Lactones
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61P 31/14 - Antivirals for RNA viruses
  • A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
  • C07C 69/24 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with monohydroxylic compounds
  • C07C 69/533 - Monocarboxylic acid esters having only one carbon-to-carbon double bond
  • C07C 69/675 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids

19.

OPTICAL PATH LENGTH CHARACTERISATION

      
Application Number GB2023052508
Publication Number 2024/069173
Status In Force
Filing Date 2023-09-27
Publication Date 2024-04-04
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Weinfurtner, Silke
  • Geelmuyden, August
  • Barroso Silveira, Vitor

Abstract

nnn), each of the interferograms comprising a reflected light beam resulting from reflection of a light beam from at least one of the first face and the second face and each of the interferograms comprising a reflected light beam with reflections from a different combination and/or sequence of surfaces. The method further comprises performing a spatial frequency transform of the interference data to generate transformed data in a spatial frequency domain and analysing features of the transformed data to determine the optical path length, wherein each feature in the transformed data corresponds to one of the interferograms in the interference data and at least some of the features are at least partially separated in the spatial frequency domain.

IPC Classes  ?

  • G01B 9/02015 - Interferometers characterised by the beam path configuration
  • G01B 9/02 - Interferometers
  • G01B 11/06 - Measuring arrangements characterised by the use of optical techniques for measuring length, width, or thickness for measuring thickness
  • G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
  • G03H 1/04 - Processes or apparatus for producing holograms

20.

ELECTRIC MOTOR AND COMPONENTS

      
Application Number GB2023052078
Publication Number 2024/033620
Status In Force
Filing Date 2023-08-07
Publication Date 2024-02-15
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Gerada, Chris
  • Gerada, David
  • Xu, Zeyuan
  • Zou, Tianjie
  • Zhang, Fengyu

Abstract

An electric machine (100) comprising a rotor (130) and a stator (140), wherein at least one of the rotor (130) and/or stator (140) comprises a toroidal winding comprising a plurality of preformed conductors.

IPC Classes  ?

  • H02K 15/04 - Processes or apparatus specially adapted for manufacturing, assembling, maintaining or repairing of dynamo-electric machines of windings prior to their mounting into the machines
  • H02K 3/12 - Windings characterised by the conductor shape, form or construction, e.g. with bar conductors arranged in slots
  • H02K 3/24 - Windings characterised by the conductor shape, form or construction, e.g. with bar conductors with channels or ducts for cooling medium between the conductors
  • H02K 9/19 - Arrangements for cooling or ventilating for machines with closed casing and closed-circuit cooling using a liquid cooling medium, e.g. oil

21.

A SYSTEM AND METHOD FOR ESTIMATING TOTAL DISSOLVED SOLIDS IN BOILER WATER

      
Application Number EP2023068800
Publication Number 2024/017667
Status In Force
Filing Date 2023-07-06
Publication Date 2024-01-25
Owner
  • SPIRAX-SARCO LIMITED (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Agolom, Michael
  • Dodds, Chris
  • Katrib, Juliano

Abstract

A system (12) for estimating total dissolved solids (TDS) concentration in boiler water is described which comprises: a sensor (14) having a transmitter configured to transmit an RF or microwave signal into the boiler water and a receiver configured to receive a reflected signal from a reflection of the RF or microwave signal by the boiler water; and an analysis module (16) configured to determine a conductivity value for the boiler water based on the reflected signal and to determine a TDS concentration for the boiler water based on the conductivity. A corresponding method is also described.

IPC Classes  ?

  • G01N 22/00 - Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more
  • G01N 33/18 - Water

22.

DISRUPTION OF EPITHELIAL BARRIERS FOR MOLECULAR DELIVERY ENHANCEMENT OR EXTRACTION OF EXTRACELLULAR FLUIDS

      
Application Number GB2023051782
Publication Number 2024/009101
Status In Force
Filing Date 2023-07-05
Publication Date 2024-01-11
Owner
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
  • NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST (United Kingdom)
Inventor
  • Webb, Kevin
  • Moradi, Emilia
  • Foss, Alexander

Abstract

The invention provides a method of delivering a payload molecule across an epithelial tissue barrier, the method comprising: applying the payload molecule to the epithelial tissue barrier, and additionally applying an agent to the epithelial tissue barrier. The agent is (i) a microbial quorum sensing signalling molecule (microbial QSSM) or a derivative or variant thereof, which is capable of disrupting the epithelial tissue barrier function, or (ii) a carboxylic acid compound, or a pharmaceutically acceptable salt, hydrate or solvate thereof.

IPC Classes  ?

  • A61K 31/47 - QuinolinesIsoquinolines
  • A61P 43/00 - Drugs for specific purposes, not provided for in groups
  • A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
  • A61K 31/426 - 1,3-Thiazoles
  • A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
  • A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies

23.

MAGNETOENCEPHALOGRAPHY METHOD AND SYSTEM

      
Application Number 18247313
Status Pending
Filing Date 2021-09-30
First Publication Date 2024-01-04
Owner The University of Nottingham (United Kingdom)
Inventor
  • Brookes, Matthew
  • Boto, Elena

Abstract

A method of reducing error in magnetoencephalography arising from the presence of a non-neuromagnetic field. The method comprises measuring, using a sensor array for measuring neuromagnetic fields, magnetic field at a plurality of discrete locations around a subject's head to provide sensor data; wherein the magnetic field measured at at least some of the locations includes a neuromagnetic field from a source of interest within a subject's brain and a non-neuromagnetic field from a source of no interest external to the brain. The measuring comprises: measuring, at at least a first subset of the locations, a magnetic field along a first direction relative to a radial axis intersecting the respective location, and measuring, at at least a second subset of the locations, a magnetic field along a second direction relative to a radial axis intersecting the respective location which is different to the first direction; and performing source reconstruction using the sensor data.

IPC Classes  ?

  • A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
  • G01R 33/00 - Arrangements or instruments for measuring magnetic variables
  • G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
  • G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
  • G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday

24.

MACROCYCLIC COMPOUNDS COMPRISING TETRAFLUOROPHENYL MOIETIES

      
Application Number GB2023051389
Publication Number 2023/233129
Status In Force
Filing Date 2023-05-26
Publication Date 2023-12-07
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Woodward, Simon
  • Turley, Andrew

Abstract

The invention provides a macrocyclic compound of Formula (I): wherein each R1 is independently an aromatic ring system that is optionally substituted, and wherein n is an integer of from 2 to 50.

IPC Classes  ?

  • C07D 341/00 - Heterocyclic compounds containing rings having three or more sulfur atoms as the only ring hetero atoms
  • C08G 75/0213 - Polyarylenethioethers derived from monomers containing one aromatic ring containing elements other than carbon, hydrogen or sulfur

25.

MICRON-SCALE 3D OBJECTS FOR THE MODULATION OF CELL PHENOTYPE FROM PRO TO ANTI-INFLAMMATORY STATES

      
Application Number GB2023051436
Publication Number 2023/233155
Status In Force
Filing Date 2023-05-31
Publication Date 2023-12-07
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Alexander, Morgan
  • Wildman, Ricky
  • Ghaemmaghami, Amir

Abstract

The invention provides the use of micro-scale three-dimensional objects on a surface, to influence the extent to which macrophage attachment occurs at the surface and/or the phenotype of macrophage that attaches to the surface. The invention provides a product, such as a healthcare implant, wherein micro- scale three-dimensional objects are provided on a surface of the product.

IPC Classes  ?

  • A61F 2/02 - Prostheses implantable into the body
  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

26.

FIBRES

      
Application Number 18010995
Status Pending
Filing Date 2021-06-15
First Publication Date 2023-09-21
Owner
  • COAL PRODUCTS LIMITED (United Kingdom)
  • The University of Nottingham (United Kingdom)
Inventor
  • Gill, Andrew
  • Snape, Colin

Abstract

A process (1, 2) for processing feedstock containing cotton fibres and PET fibres, the process (1, 2) comprises: i. heating a suspension of feedstock containing cotton fibres and PET fibres in water at a temperature above 180° C. to produce a mixture comprising char; ii. removing the water from the mixture comprising char; iii. adding a base to the mixture comprising char to produce a terephthalate salt in a liquid phase; iv. removing the char from the liquid phase to produce dried char; v. acidifying the liquid phase to produce terephthalic acid.

IPC Classes  ?

  • C08J 11/14 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with steam or water
  • C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material
  • C07C 51/02 - Preparation of carboxylic acids or their salts, halides, or anhydrides from salts of carboxylic acids
  • C08J 11/06 - Recovery or working-up of waste materials of polymers without chemical reactions

27.

BIO-MANUFACTURING OF D-BIOTIN

      
Application Number GB2023050648
Publication Number 2023/175351
Status In Force
Filing Date 2023-03-17
Publication Date 2023-09-21
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Van Eck Conradie, Alex
  • Croft, Anna
  • Arthurs, Hayley
  • Jäger, Christof Martin
  • Paiva, Ana Caroline

Abstract

bioBbioB), to enhance D-biotin biosynthesis. The invention also provides optimised methods of culturing the genetically engineered cells to produce D-biotin, recovering the D-biotin from cultivation media, and purifying the D-biotin.

IPC Classes  ?

  • C12N 9/10 - Transferases (2.)
  • C07K 14/245 - Escherichia (G)
  • C12P 17/18 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
  • C12R 1/19 - Escherichia coli

28.

AZETIDINE DERIVATIVES FOR THE TREATMENT OF INTEGRIN ASSOCIATED DISEASES

      
Application Number 18004757
Status Pending
Filing Date 2021-07-08
First Publication Date 2023-08-17
Owner University of Nottingham (United Kingdom)
Inventor
  • Mcinally, Thomas
  • Macdonald, Simon
  • Moody, Christopher
  • Hatley, Richard
  • Barrett, Tim
  • Watson, Morag
  • Richie, Timothy

Abstract

The invention relates to novel compounds of formula (I), the compounds being capable of acting as avβ6 integrin antagonists, their use in the treatment of disease, their methods of manufacture and compositions comprising said compounds for such purposes (I) wherein R1 is selected from: R1a, —C(O)R1a, —C(O)OR1a —C(O)NHR1a, —C(O)N(R1a)2, —SO2R1a, wherein R1a are each independently selected from: alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl, each of which may be optionally substituted; R2 is selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R2a are each independently selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R3 is selected from: hydrogen, optionally substituted alkyl or optionally substituted alkoxyl; R4 is hydroxyl; Ar1 is an optionally substituted heteroaryl or bicyclic heteroaryl; and L is a linker; or a pharmaceutically acceptable salt thereof. The invention relates to novel compounds of formula (I), the compounds being capable of acting as avβ6 integrin antagonists, their use in the treatment of disease, their methods of manufacture and compositions comprising said compounds for such purposes (I) wherein R1 is selected from: R1a, —C(O)R1a, —C(O)OR1a —C(O)NHR1a, —C(O)N(R1a)2, —SO2R1a, wherein R1a are each independently selected from: alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl, each of which may be optionally substituted; R2 is selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R2a are each independently selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R3 is selected from: hydrogen, optionally substituted alkyl or optionally substituted alkoxyl; R4 is hydroxyl; Ar1 is an optionally substituted heteroaryl or bicyclic heteroaryl; and L is a linker; or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

29.

THERMAL SPRAY SYSTEM AND COATING

      
Application Number GB2022053187
Publication Number 2023/111539
Status In Force
Filing Date 2022-12-13
Publication Date 2023-06-22
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Hussain, Tanvir
  • Venturi, Federico
  • Chadha, Sunil
  • Leng, Kah

Abstract

A thermal spray system (50), a thermal spray nozzle (200) and a method of thermal spray coating are disclosed. The thermal spray system (50) comprises a combustion chamber (101) configured to produce a thermal spray flame (106) from the reaction product of a fuel fluid and an oxidiser fluid; a first feedstock injection port (107) configured to entrain a first feedstock material in the thermal spray flame (106); an inert gas injection port (202) configured to shroud the thermal spray flame (106) with an inert gas; and a second feedstock injection port (207) configured to entrain a second feedstock material in the thermal spray flame (106). The first feedstock injection port (107) is spaced apart from the second feedstock injection port (207) along a longitudinal axis of the thermal spray flame (106).

IPC Classes  ?

  • B05B 7/00 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
  • B05B 12/00 - Arrangements for controlling deliveryArrangements for controlling the spray area

30.

TOROIDAL PROCESSING CHAMBER

      
Application Number GB2022052624
Publication Number 2023/067314
Status In Force
Filing Date 2022-10-14
Publication Date 2023-04-27
Owner
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
  • MORTIMER TECHNOLOGY HOLDINGS LIMITED (United Kingdom)
Inventor
  • Kingman, Samuel
  • Dodds, Christopher
  • Rodriguez, Jose
  • Dodson, Christopher Edward

Abstract

An apparatus for processing a material is disclosed. The apparatus comprises a toroidal bed chamber (110) and a waveguide (120). The toroidal bed chamber (110) has chamber walls comprising an inner sidewall (111), an outer sidewall (112) and a base (113), the inner sidewall (111), outer sidewall (112) and base (113) at least partly defining a toroidal volume for material to circulate within. A circulation fluid inlet (130) is provided for introducing a circulation fluid (131) with a velocity component tangential to the toroidal volume for causing the material to circulate within the toroidal volume. The waveguide (120) is for receiving microwave radiation and communicating the microwave radiation to interior of the toroidal bed chamber. The waveguide (120) comprises at least one microwave transparent window (121) in the inner sidewall (111), the outer sidewall (112) or the base (113).

IPC Classes  ?

  • H05B 6/80 - Apparatus for specific applications
  • B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves

31.

OPTICAL SENSOR

      
Application Number GB2022052294
Publication Number 2023/037122
Status In Force
Filing Date 2022-09-09
Publication Date 2023-03-16
Owner
  • GILL CORPORATE LIMITED (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
  • THE UNIVERSITY OF KITAKYUSHU (Japan)
  • PLYMOUTH MARINE LABORATORY (United Kingdom)
Inventor
  • Korposh, Serhiy
  • Lee, Seung-Woo
  • Birtwell, Samuel William
  • Hromadka, Jiri
  • Somerville-Woodward, Ernest Malcolm

Abstract

A coating for a transmissive optical component of an optical sensor comprises tetrakis(4-sulfophenyl)porphine (TSPP) crosslinked with a diazo resin (DAR). The coating may comprise alternate layers of (a) DAR and (b) a mixture of TSPP and poly(styrene sulfonate) (PSS). An optical sensor is provided for detecting an analyte that modifies the absorption spectrum of TSPP. The sensor comprises a transmissive optical component, a light source at an input side of the optical component and a detector for detecting light at at least one frequency at an output side of the optical component. The optical component has a coating as mentioned above.

IPC Classes  ?

  • G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
  • G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour

32.

POLYMERIC PARTICULATE MATERIAL

      
Application Number GB2022052226
Publication Number 2023/031602
Status In Force
Filing Date 2022-08-31
Publication Date 2023-03-09
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Krumins, Eduards
  • Irving, Samuel
  • Howdle, Steven
  • Goodridge, Ruth
  • Tuck, Christopher John

Abstract

The invention provides particulate material suitable for use in manufacturing a three-dimensional object, the material comprising a plurality of particles. Each particle has a thermoplastic polymeric core; and a polymeric shell that coats the polymeric core. The polymeric core makes up 75wt% or more of each particle. The polymeric shell is formed from a co-polymer of a major monomer and a minor monomer, wherein the major monomer comprises a polymerisable group, and the minor monomer comprises (i) a polymerisable group; and (ii) a functional component, and wherein the co-polymer is formed by reaction of the polymerisable group on the major monomer with the polymerisable group on the minor monomer.

IPC Classes  ?

  • B29C 64/10 - Processes of additive manufacturing
  • C08F 265/06 - Polymerisation of acrylate or methacrylate esters on to polymers thereof
  • C08J 3/12 - Powdering or granulating
  • C09B 69/10 - Polymeric dyesReaction products of dyes with monomers or with macromolecular compounds

33.

MICROTOPOGRAPHIES AND USES THEREOF

      
Application Number 17799910
Status Pending
Filing Date 2021-02-15
First Publication Date 2023-03-02
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Alexander, Morgan
  • Williams, Paul
  • Ghaemmaghami, Amir

Abstract

A microtopography system for modulating one or more cellular processes on a surface is described. The microtopography system comprising: a repeated microtopographic pattern, said microtopographic pattern comprising: an array of repeated micropillars applied to a surface of a product, said micropillars being formed of surface structures between 1-100 μm in height, and 1-50 μm in width. The microtopographic pattern acts to modulate one or more cellular processes on the surface.

IPC Classes  ?

  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

34.

Sealed interface power module housing

      
Application Number 17405653
Grant Number 11956914
Status In Force
Filing Date 2021-08-18
First Publication Date 2023-02-23
Grant Date 2024-04-09
Owner
  • VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (USA)
  • UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Dimarino, Christina
  • Cairnie, Mark
  • Boroyevich, Dushan
  • Burgos, Rolando
  • Johnson, C. Mark

Abstract

A number of different sealed interfaces for power modules are described. In one example, a sealed interface includes a printed circuit board including a contact pad for power conduction to a bus bar of the printed circuit board, a semiconductor module including at least one power transistor, a terminal pin electrically coupled to the power module, and a housing for the power module. The housing includes an open terminal aperture that extends through the housing. The printed circuit board is seated upon the open terminal aperture, to close and seal the open terminal aperture, with the contact pad positioned within the open terminal aperture. The terminal pin contacts the contact pad of the printed circuit board within the open terminal aperture, and the open terminal aperture comprises a transitional feature to abate electric field intensity around an interface between the open terminal aperture and the printed circuit board.

IPC Classes  ?

  • H05K 7/00 - Constructional details common to different types of electric apparatus
  • H05K 1/18 - Printed circuits structurally associated with non-printed electric components
  • H05K 5/00 - Casings, cabinets or drawers for electric apparatus
  • H05K 7/14 - Mounting supporting structure in casing or on frame or rack

35.

SAMPLE PROPERTY DETERMINATION

      
Application Number GB2022052075
Publication Number 2023/021270
Status In Force
Filing Date 2022-08-09
Publication Date 2023-02-23
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Clark, Matt
  • Dryburgh, Paul
  • Li, Wenqi
  • Smith, Richard

Abstract

A method of determining one or more properties of a sample, comprising: determining, at a plurality of generation sites of the sample, a plurality of acoustic velocity measurements, the plurality of acoustic velocity measurements using different acoustic propagation directions; and determining a best fit elasticity for the acoustic velocity measurements at different acoustic propagation directions at the plurality of generation sites, wherein determining a best fit elasticity comprises assuming a common elasticity for the plurality of generation sites while allowing crystallographic orientation to vary.

IPC Classes  ?

  • G01N 29/04 - Analysing solids
  • G01N 29/07 - Analysing solids by measuring propagation velocity or propagation time of acoustic waves
  • G01N 29/44 - Processing the detected response signal

36.

ATOMICALLY DISPERSED METAL CATALYST

      
Application Number GB2022052018
Publication Number 2023/007192
Status In Force
Filing Date 2022-07-29
Publication Date 2023-02-02
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Fernandes, Jesum Alves

Abstract

A method for preparing an atomically dispersed metal catalyst, comprising: depositing atomically dispersed metal onto a support by magnetron sputtering to directly form a catalyst comprising metal particles, with mean diameter up to 1 nm, dispersed on the surface of the support, wherein the support is water insoluble.

IPC Classes  ?

37.

CORNEAL TISSUE

      
Application Number 17776990
Status Pending
Filing Date 2020-11-13
First Publication Date 2022-12-08
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Sidney, Laura
  • Hopkinson, Andrew
  • Mcintosh, Owen

Abstract

The invention provides an isolated dehydrated corneal tissue, comprising a full thickness corneal stroma, and substantially all, or all, of the Bowman's membrane, wherein the stroma contains cellular material. Also provided is a method to product the tissue and uses of the tissue.

IPC Classes  ?

  • A61F 2/14 - Eye parts, e.g. lenses or corneal implantsArtificial eyes
  • A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
  • C12N 5/079 - Neural cells

38.

MAGNETIC SHIELD

      
Application Number 17753926
Status Pending
Filing Date 2020-09-18
First Publication Date 2022-12-08
Owner The University of Nottingham (United Kingdom)
Inventor
  • Fromhold, Mark
  • Bowtell, Richard
  • Brookes, Matthew
  • Packer, Michael
  • Sims, Dominic
  • Hobson, Peter

Abstract

A method of designing a magnetic shield comprising a structure enclosing a space, the structure comprising passive magnetic shielding material and a winding configured to produce a specified magnetic within the structure when current is passed through the winding, is disclosed. The method comprises determining an optimised configuration of the winding accounting for the presence of the passive magnetic shield material by implementing one or more boundary conditions at the surface of the passive magnetic shielding material.

IPC Classes  ?

  • H01F 7/20 - ElectromagnetsActuators including electromagnets without armatures

39.

A MAGNETIC SHIELD

      
Application Number EP2022063808
Publication Number 2022/238588
Status In Force
Filing Date 2022-05-20
Publication Date 2022-11-17
Owner
  • MAGNETIC SHIELDS LIMITED (United Kingdom)
  • UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Woolger, David
  • Chalmers, James
  • Farmer, Joseph
  • Dawson, Eliot
  • Bowtell, Richard
  • Brookes, Matthew
  • Holmes, Niall
  • Glover, Paul

Abstract

An active magnetic shield system, comprising an array of magnetic field sensors arranged to sense a local magnetic field. An array of magnetic field elements are arranged produce a magnetic field. Each magnetic field element has a unit coil for mounting to a plurality of surfaces arranged in at least 3 planes to define an enclosed cancellation volume, and to produce a vector magnetic field pattern.

IPC Classes  ?

40.

DECELLULARIZED TISSUE HYDROGELS

      
Application Number GB2022051093
Publication Number 2022/229653
Status In Force
Filing Date 2022-04-29
Publication Date 2022-11-03
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • White, Lisa
  • Jones, Joshua

Abstract

The invention provides a decellularized tissue hydrogel cross-linked with a polyphenol, and a method of preparing a cross-linked decellularized tissue hydrogel, the method comprising the steps of: a) providing at least one decellularized tissue hydrogel; and b) cross-linking the at least one decellularized tissue hydrogel with a polyphenol.

IPC Classes  ?

  • A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
  • A61L 27/52 - Hydrogels or hydrocolloids

41.

IMPROVEMENTS IN OR RELATING TO PHOTOGRAMMETRY

      
Application Number 17631383
Status Pending
Filing Date 2020-07-21
First Publication Date 2022-10-20
Owner University of Nottingham (United Kingdom)
Inventor
  • Leach, Richard
  • Piano, Samanta
  • Sims-Waterhouse, Danny

Abstract

Photogrammetric analysis of an object is carried out by capturing images of the object. Photogrammetric analysis requires the capture of multiple overlapping images of the object from various camera positions. These images are then processed to generate a three-dimensional (3D) point cloud representing the object in 3D space. A 3D model of the object is used to generate a model 3D point cloud. Based on the modelled point cloud and camera optics, the visibility of each point in the 3D point cloud is determined for a range of possible camera positions. The radial component of the camera is fixed by defining a shell of suitable camera positions around the part and for each position on the defined shell, the quality as a function of camera position is calculated. This defines a density function over the potential camera positions. Initial camera positions are selected based on the density function.

IPC Classes  ?

  • G06V 20/64 - Three-dimensional objects
  • G01C 11/02 - Picture-taking arrangements specially adapted for photogrammetry or photographic surveying, e.g. controlling overlapping of pictures
  • G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods

42.

HIGH SENSITIVITY ANALYSIS OF NANOGRAM QUANTITIES OF GLYCOSAMINOGLYCANS USING TOF-SIMS

      
Application Number GB2022050746
Publication Number 2022/200801
Status In Force
Filing Date 2022-03-24
Publication Date 2022-09-29
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Hook, Andrew
  • Merry, Catherine Louise Ruby

Abstract

Glycosaminoglycans (GAGs) are important biopolymers that differ in the sequence of saccharide units, and in post-polymerization alterations at various positions, making these molecules complex and challenging to analyse. We have developed an approach that enables small quantities (< 200 ng) of hundreds of different GAGs to be analysed within a short time frame (3-4 hours). Time of flight secondary ions mass spectrometry 10 together with multivariate analysis was used to analyse an array of over 400 GAG samples. Resultant spectra were derived from the whole molecules and did not require pre-digestion. All 6 GAG types were successfully discriminated, both alone and in the presence of fibronectin. We also distinguished between pharmaceutical grade heparin derived from different animal species and from different suppliers to a sensitivity as 15 low as 0.001 wt%. This approach is highly beneficial in the quality control of GAGs produced for therapeutic applications and for characterising GAGs within biomaterials or from in vitro cell culture.

IPC Classes  ?

  • G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
  • A61K 31/726 - Glycosaminoglycans, i.e. mucopolysaccharides
  • C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof
  • G01N 23/2258 - Measuring secondary ion emission, e.g. secondary ion mass spectrometry [SIMS]

43.

REACTION APPARATUS

      
Application Number 17635480
Status Pending
Filing Date 2020-08-14
First Publication Date 2022-09-22
Owner
  • UNIVERSITY OF NOTTINGHAM (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • George, Michael
  • Poliakoff, Martyn
  • Lee, Darren
  • Pickering, Stephen
  • Sharabi, Medhat

Abstract

An apparatus for carrying out chemical reactions is provided. The apparatus comprises a first reactor/reaction zone for carrying out a first chemical reaction and a second reactor/reaction zone for carrying out a second chemical reaction. Each reactor/reaction zone comprises: a) an inner surface and an outer surface which are spaced apart from each other to define a reaction volume configured such that, in use, a respective chemical reaction takes place in the reaction volume, and wherein the inner surface and outer surface are configured for relative rotation with respect to each other, (b) an inlet for introduction of a reagent to the reaction volume, and (b) an outlet through which a reaction product can leave the reaction volume. The reaction products of the first reactor/reaction zone comprise reagents of the second reactor/reaction zone.

IPC Classes  ?

  • B01J 19/18 - Stationary reactors having moving elements inside
  • B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves

44.

FIBRE OPTIC CHEMICAL SENSING

      
Application Number GB2022050537
Publication Number 2022/185042
Status In Force
Filing Date 2022-03-01
Publication Date 2022-09-09
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Morgan, Stephen
  • Liu, Liangliang
  • Korposh, Serhiy
  • Correia, Ricardo

Abstract

The present application relates to a chemical sensor (100), comprising: an optical fibre (110); an optical cavity, optically coupled to the optical fibre (110), wherein the optical cavity comprises a dye with an absorbance and/or fluorescence spectrum that is responsive to a chemical concentration; a spectrometer (120) configured to determine a spectral response of the optical cavity (110); a processor (130) configured to determine a first chemical concentration from the dye absorbance and/or fluorescence spectrum by spectroscopy, and to determine a wavelength of one or more Fabry-Pérot interference fringes from the optical cavity (110). Also disclosed is a method of chemical sensing using a fibre optic sensor. Also disclosed is a method of fabricating a chemical sensor, comprising: coating, by sol-gel deposition, a distal end (117) of an optical fibre (110) with a silica matrix comprising dye; drying the silica matrix comprising dye in a dry inert gas. Aspects of the invention may be used in a healthcare context.

IPC Classes  ?

  • G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
  • G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
  • G01N 21/81 - Indicating humidity
  • G01N 21/64 - FluorescencePhosphorescence

45.

Broadband filter

      
Application Number 17608724
Grant Number 11909367
Status In Force
Filing Date 2020-05-04
First Publication Date 2022-09-08
Grant Date 2024-02-20
Owner
  • The Thinking Pod Innovations Ltd (United Kingdom)
  • The University of Nottingham (United Kingdom)
Inventor
  • Zhang, Zhe
  • Espina, Jordi
  • Johnson, Mark

Abstract

The present disclosure relates to a broadband filter for confining or attenuating electromagnetic interference noise from one or more electrical signal sources, In an embodiment, the broadband filter comprises one or more filter stages electrically coupled by galvanic or by electromagnetic means to the one or more electrical signal sources for confining or attenuating conducted electromagnetic interference noise; one or more conductive shields electrically coupled by galvanic or by electromagnetic means to the electrical signal sources wherein the shields encapsulate the filter stages for confining or attenuating conducted and/or radiated electromagnetic interference noise; and one or more conductive partition layers to encapsulate the one or more filter stages such that the partition layers electromagnetically couple adjacent filter stages for a selected frequency range of the electromagnetic interference noise. The thickness of the conductive partition layers is chosen to control the degree of coupling.

IPC Classes  ?

  • H03H 1/00 - Constructional details of impedance networks whose electrical mode of operation is not specified or applicable to more than one type of network
  • H03H 7/01 - Frequency selective two-port networks

46.

Enhanced Transfection

      
Application Number 17440991
Status Pending
Filing Date 2020-03-23
First Publication Date 2022-07-07
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Dixon, James

Abstract

The invention relates to a method of transfecting a cell with a molecule, the method comprising the steps of: adding a molecule for transfection to the cells; and modulating the activity of protein kinase C (PKC) in the cell and/or providing a pH responsive peptide comprising between about 5 and about 20 histidine residues; and related compositions and uses in therapy.

IPC Classes  ?

  • C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
  • C07K 16/44 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere

47.

FUNGAL STRAINS, PRODUCTION AND USES THEREOF

      
Application Number 17604485
Status Pending
Filing Date 2020-04-16
First Publication Date 2022-07-07
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Dyer, Paul

Abstract

This invention relates to novel Penicillium strains, the production of novel Penicillium strains, and the use of novel Penicillium strains in various end applications.

IPC Classes  ?

  • A23C 19/032 - Making cheese curd characterised by the use of specific microorganisms, or enzymes of microbial origin
  • C12N 3/00 - Spore-forming or isolating processes
  • C12N 1/14 - Fungi Culture media therefor
  • A23C 19/068 - Particular types of cheese
  • G01N 30/72 - Mass spectrometers

48.

GENETIC CONSTRUCT AND USES THEREOF

      
Application Number 17426092
Status Pending
Filing Date 2020-01-28
First Publication Date 2022-07-07
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Minton, Nigel
  • Blasco, Ines Canadas
  • Groothuis, Daphne
  • Zygouropoulou, Maria

Abstract

A spore-forming cell comprising a first nucleotide sequence encoding a riboswitch and a transcriptional activator, wherein the riboswitch modulates translation of the transcriptional activator in response to a First inducer, and a second nucleotide sequence encoding a target gene that regulates spore formation, wherein the target gene is expressed in response to a second inducer and translation of the transcriptional activator. Also provided is a method of culturing a spore-forming cell and a method of creating a spore, as well as uses of spore-forming cells and spores.

IPC Classes  ?

  • C12N 15/67 - General methods for enhancing the expression
  • A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
  • C12N 3/00 - Spore-forming or isolating processes

49.

Quantum gravimeters and gradiometers

      
Application Number 17596523
Grant Number 12242019
Status In Force
Filing Date 2020-06-12
First Publication Date 2022-06-02
Grant Date 2025-03-04
Owner
  • The University of Nottingham (United Kingdom)
  • University of Vienna (Austria)
Inventor
  • Fuentes Guridi, Ivette
  • Rätzel, Dennis
  • Ibarra, Tupac Bravo
  • Bruschi, David Edward

Abstract

A method of measuring an acceleration using one or more trapped BECs and at least two atomic field modes within those BECs is described. A density distribution of at least one of the one or more BECs is modified by the acceleration, which leads to a change of the field modes' time evolution. The method comprises: selecting two modes that are differently affected by the acceleration; and measuring the acceleration-induced difference; and using the measured acceleration-induced difference to infer the acceleration. Also described is a method of measuring a field gradient using one or more trapped BECs. Each of the trapped BECs has a density distribution, and at least two atomic modes within those BECs, wherein the density distributions of the one or more BECs are modified by the field, which leads to a change of the atomic modes' time evolution. The method comprises selecting two atomic modes that are differently affected by the field; and measuring a field-induced difference between the selected atomic modes; and using the measured field-induced difference to infer a gradient of the field.

IPC Classes  ?

  • G01V 7/02 - Measuring gravitational fields or wavesGravimetric prospecting or detecting Details
  • G01P 15/08 - Measuring accelerationMeasuring decelerationMeasuring shock, i.e. sudden change of acceleration by making use of inertia forces with conversion into electric or magnetic values
  • G01V 7/00 - Measuring gravitational fields or wavesGravimetric prospecting or detecting

50.

MAGNETOENCEPHALOGRAPHY METHOD AND SYSTEM

      
Document Number 03194163
Status Pending
Filing Date 2021-09-30
Open to Public Date 2022-04-07
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Brookes, Matthew
  • Boto, Elena

Abstract

A method of reducing error in magnetoencephalography arising from the presence of a non-neuromagnetic field. The method comprises measuring, using a sensor array for measuring neuromagnetic fields, magnetic field at a plurality of discrete locations around a subject's head to provide sensor data, wherein the magnetic field measured at at least some of the locations includes a neuromagnetic field from a source of interest within a subject's brain and a non-neuromagnetic field from a source of no interest external to the brain. The measuring comprises: measuring, at at least a first subset of the locations, a magnetic field along a first direction relative to a radial axis intersecting the respective location, and measuring, at at least a second subset of the locations, a magnetic field along a second direction relative to a radial axis intersecting the respective location which is different to the first direction; and performing source reconstruction using the sensor data.

IPC Classes  ?

  • A61B 5/242 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
  • A61B 5/243 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetocardiographic [MCG] signals

51.

MAGNETOENCEPHALOGRAPHY METHOD AND SYSTEM

      
Application Number GB2021052537
Publication Number 2022/069896
Status In Force
Filing Date 2021-09-30
Publication Date 2022-04-07
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Brookes, Matthew
  • Boto, Elena

Abstract

A method of reducing error in magnetoencephalography arising from the presence of a non-neuromagnetic field. The method comprises measuring, using a sensor array for measuring neuromagnetic fields, magnetic field at a plurality of discrete locations around a subject's head to provide sensor data, wherein the magnetic field measured at at least some of the locations includes a neuromagnetic field from a source of interest within a subject's brain and a non-neuromagnetic field from a source of no interest external to the brain. The measuring comprises: measuring, at at least a first subset of the locations, a magnetic field along a first direction relative to a radial axis intersecting the respective location, and measuring, at at least a second subset of the locations, a magnetic field along a second direction relative to a radial axis intersecting the respective location which is different to the first direction; and performing source reconstruction using the sensor data.

IPC Classes  ?

  • A61B 5/242 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
  • A61B 5/243 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetocardiographic [MCG] signals
  • G01R 33/00 - Arrangements or instruments for measuring magnetic variables
  • G01R 33/035 - Measuring direction or magnitude of magnetic fields or magnetic flux using superconductive devices

52.

ULTRAHAPTICONS

      
Application Number GB2021052415
Publication Number 2022/058738
Status In Force
Filing Date 2021-09-17
Publication Date 2022-03-24
Owner
  • ULTRALEAP LIMITED (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Brown, Eddie

Abstract

Described herein are "Ultrahapticons," which are a set of tangible and recognizable mid-air haptic icons that have been derived from research study participants' metaphorical associations with car infotainment features. In line with semiotic theory (the study of signs), data from the study was analyzed to identify key characteristics that when realized in mid-air haptic form, would enable a user to "feel" the feature they are interacting with. Their use is not limited to an automotive context, they can be instrumented to any application that exhibits the same feature functionality i.e. home entertainment system, laptop UI's, digital communication, Extended Reality (XR), and the like.

IPC Classes  ?

  • G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

53.

Ultrahapticons

      
Application Number 17477536
Grant Number 11886639
Status In Force
Filing Date 2021-09-17
First Publication Date 2022-03-17
Grant Date 2024-01-30
Owner
  • ULTRALEAP LIMITED (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Brown, Eddie

Abstract

Described herein are “Ultrahapticons,” which are a set of tangible and recognizable mid-air haptic icons that have been derived from research study participants' metaphorical associations with car infotainment features. In line with semiotic theory (the study of signs), data from the study was analyzed to identify key characteristics that when realized in mid-air haptic form, would enable a user to “feel” the feature they are interacting with. Their use is not limited to an automotive context, they can be instrumented to any application that exhibits the same feature functionality i.e. home entertainment system, laptop UI's, digital communication, Extended Reality (XR), and the like.

IPC Classes  ?

  • G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
  • B06B 1/16 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of mechanical energy operating with systems involving rotary unbalanced masses

54.

Raman spectroscopy method and apparatus

      
Application Number 17276596
Grant Number 11774364
Status In Force
Filing Date 2019-09-17
First Publication Date 2022-02-10
Grant Date 2023-10-03
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Notingher, Ioan
  • Corden, Christopher
  • Shipp, Dustin

Abstract

Apparatus and methods for acquiring a Raman spectral map of a sample including a material species. The apparatus includes: a pulsed illumination source providing pulsed illumination radiation for exciting the sample and producing scattered radiation; a microscope objective focusing the pulsed illumination radiation onto a region of the sample corresponding to a data point of the map, and collecting emitted radiation from the region; a translation stage translating the sample relative to the microscope objective in at least two directions; a spectral filter spectrally filtering the emitted radiation collected by the objective to obtain a filtered portion of radiation corresponding to a characteristic Raman spectral feature of the material species; a detector receiving the filtered portion and providing output electrical pulses indicative thereof; and readout electronics applying a time gate to the output electrical pulses to distinguish detection events corresponding to the Raman scattered radiation from events associated with photoluminescence.

IPC Classes  ?

55.

AZETIDINE DERIVATIVES FOR THE TREATMENT OF INTEGRIN ASSOCIATED DISEASES

      
Document Number 03188922
Status Pending
Filing Date 2021-07-08
Open to Public Date 2022-01-13
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Mcinally, Thomas
  • Macdonald, Simon
  • Moody, Christopher
  • Hatley, Richard
  • Barrett, Tim
  • Watson, Morag
  • Ritchie, Timothy

Abstract

The invention relates to novel compounds of formula (I), the compounds being capable of acting as avß6 integrin antagonists, their use in the treatment of disease, their methods of manufacture and compositions comprising said compounds for such purposes (I) wherein R1 is selected from: R1a, -C(O)R1a, -C(O)OR1a -C(O)NHR1a, -C(O)N(R1a)2, -SO2R1a, wherein R1a are each independently selected from: alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl, each of which may be optionally substituted; R2 is selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R2a are each independently selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R3 is selected from: hydrogen, optionally substituted alkyl or optionally substituted alkoxyl; R4 is hydroxyl; Ar1 is an optionally substituted heteroaryl or bicyclic heteroaryl; and L is a linker; or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

  • C07D 471/04 - Ortho-condensed systems
  • A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
  • A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
  • A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
  • A61P 11/00 - Drugs for disorders of the respiratory system
  • A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue
  • A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
  • A61P 35/00 - Antineoplastic agents

56.

AZETIDINE DERIVATIVES FOR THE TREATMENT OF INTEGRIN ASSOCIATED DISEASES

      
Application Number GB2021051742
Publication Number 2022/008918
Status In Force
Filing Date 2021-07-08
Publication Date 2022-01-13
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Mcinally, Thomas
  • Macdonald, Simon
  • Moody, Christopher
  • Hatley, Richard
  • Barrett, Tim
  • Watson, Morag
  • Richie, Timothy

Abstract

v6 6 integrin antagonists, their use in the treatment of disease, their methods of manufacture and compositions comprising said compounds for such purposes (I) wherein R1is selected from: R1a, -C(O)R1a, -C(O)OR1a-C(O)NHR1a, -C(O)N(R1a222R1a, wherein R1aare each independently selected from: alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl, each of which may be optionally substituted; R2is selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R2aare each independently selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R3is selected from: hydrogen, optionally substituted alkyl or optionally substituted alkoxyl; R4is hydroxyl; Ar1 is an optionally substituted heteroaryl or bicyclic heteroaryl; and L is a linker; or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

  • C07D 471/04 - Ortho-condensed systems
  • A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
  • A61P 11/00 - Drugs for disorders of the respiratory system
  • A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
  • A61P 35/00 - Antineoplastic agents
  • A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
  • A61K 31/397 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine

57.

Magnetic optimization

      
Application Number 17309215
Grant Number 11538602
Status In Force
Filing Date 2019-11-11
First Publication Date 2021-12-23
Grant Date 2022-12-27
Owner The University of Nottingham (United Kingdom)
Inventor
  • Fromhold, Mark
  • Welch, Nathan
  • Sims, Dominic
  • Ferreras, Jorge
  • Taylor, Ian

Abstract

A method of designing at least one coil for producing a magnetic field is disclosed. The method comprises: i) setting a performance target comprising: a target magnetic field, and at least two of a target power, a target resistance, a target size and/or weight, a target supply voltage or current, and a target inductance; ii) determining initial design parameters for the at least one coil; iii) modelling performance with the current design parameters to determine a simulated performance against each of the performance targets; iv) calculating a penalty function based on the difference between the simulated performance and the performance targets; v) modifying the design parameters in order to reduce the penalty function; vi) iterating steps iii) to v) until the penalty function or simulated performance has met an acceptance condition.

IPC Classes  ?

  • G06F 30/20 - Design optimisation, verification or simulation
  • G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
  • H01F 7/20 - ElectromagnetsActuators including electromagnets without armatures

58.

FIBRES

      
Application Number GB2021051486
Publication Number 2021/255427
Status In Force
Filing Date 2021-06-15
Publication Date 2021-12-23
Owner
  • COAL PRODUCTS LIMITED (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Gill, Andrew
  • Snape, Colin

Abstract

A process (1, 2) for processing feedstock containing cotton fibres and PET fibres, the process (1, 2) comprises: i. heating a suspension of feedstock containing cotton fibres and PET fibres in water at a temperature above 180 °C to produce a mixture comprising char; ii. removing the water from the mixture comprising char; iii. adding a base to the mixture comprising char to produce a terephthalate salt in a liquid phase; iv. removing the char from the liquid phase to produce dried char; v. acidifying the liquid phase to produce terephthalic acid.

IPC Classes  ?

  • C07C 51/09 - Preparation of carboxylic acids or their salts, halides, or anhydrides from carboxylic acid esters or lactones

59.

CANCER SCREENING TEST

      
Application Number GB2021051102
Publication Number 2021/224632
Status In Force
Filing Date 2021-05-06
Publication Date 2021-11-11
Owner
  • NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Fateen, Waleed Amr Abdelkader
  • Armour, John Anthony
  • Aithal, Guruprasad Padur

Abstract

A method of diagnosing cancer or screening for cancer or a pre-cancerous condition in a subject. The method comprises the steps of calculating the ratio value between the copy number at a first genomic locus that characteristically exhibits a copy number gain in cancer and a second genomic locus that characteristically exhibits a copy number loss in cancer in a DNA sample obtained from the subject; and determining whether the ratio value exceeds a predetermined threshold value.

IPC Classes  ?

  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

60.

APPARATUS AND METHOD FOR MEASUREMENT OF BOWEL WALL INFLAMMATION OR PERMEABILITY

      
Application Number GB2021050473
Publication Number 2021/171015
Status In Force
Filing Date 2021-02-24
Publication Date 2021-09-02
Owner
  • NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Williams, Hannah
  • Scott, Robert
  • Gowland, Penelope Anne
  • Aithal, Guruprasad Padur

Abstract

A method of measuring the inflammation or permeability of the bowel wall is provided. The method comprises obtaining nuclear magnetic resonance measurements, in the form of an image, of at least a bowel including the bowel wall. A portion of the bowel wall is isolated within the image. From the image, a nuclear magnetic resonance measurement is determined for the isolated bowel wall. A measurement of the inflammation or permeability of the isolated bowel wall is then calculated based on its nuclear magnetic resonance measurement.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/0515 - Magnetic particle imaging
  • A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

61.

MONITORING PHYSIOLOGICAL PARAMETERS

      
Application Number 17250821
Status Pending
Filing Date 2019-09-03
First Publication Date 2021-08-19
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Morgan, Stephen
  • Hayes-Gill, Barrie
  • Korposh, Serhiy
  • Correia, Ricardo

Abstract

The present invention relates to a system (100) for monitoring one or more physiological parameters of an individual. The system (100) comprises an optical fibre assembly (110) configured to measure one or more physiological parameters of an individual, and a pressure sensor (120) configured to measure a contact pressure of the optical fibre assembly (110) on the individual. The pressure sensor (120) comprises an optical fibre (122) comprising a transducer fibre Bragg grating (127) embedded in a matrix (121). The matrix (121) is configured to cause longitudinal strain in the transducer fibre Bragg grating (127) in response to the matrix (121) being subject to a transverse load. The one or more physiological parameters that the system (100) is for monitoring may include blood oxygen saturation (Sp O2), capillary refill time (CRT), heart rate, blood flow and CO2 emissions from skin.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G02B 6/02 - Optical fibres with cladding
  • D04B 1/16 - Other fabrics or articles characterised primarily by the use of particular thread materials synthetic threads
  • D03D 15/547 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads with optical functions other than colour, e.g. comprising light-emitting fibres
  • D05C 17/00 - Embroidered or tufted productsBase fabrics specially adapted for embroidered workInserts for producing surface irregularities in embroidered products
  • A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters

62.

MATERIALS CHEMISTRIES AND MICROTOPOGRAPHIES AND USES THEREOF

      
Application Number IB2021051274
Publication Number 2021/161290
Status In Force
Filing Date 2021-02-15
Publication Date 2021-08-19
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Alexander, Morgan
  • Ghaemmaghami, Amir
  • Williams, Paul
  • Avery, Simon
  • Hook, Andrew
  • Rose, Felicity
  • Denning, Chris

Abstract

A microtopography system for modulating one or more cellular processes on a surface is described. In particular a microtopography system comprising: a repeated microtopographic pattern and a polymer coating, said microtopographic pattern comprising: an array of repeated micropillars applied to a surface of a product, said micropillars being formed of surface structures between 1-100 μm in height, and 1-50 μm in width; and said polymer coating comprising one of a (meth)acrylate or (meth)acrylamide monomer, or mixture of two (meth)acrylate or (meth)acrylamide monomers.The microtopographic pattern and said polymer coating act to modulate one or more cellular processes on the surface.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

63.

MICROTOPOGRAPHIES AND USES THEREOF

      
Application Number IB2021051275
Publication Number 2021/161291
Status In Force
Filing Date 2021-02-15
Publication Date 2021-08-19
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Alexander, Morgan
  • Williams, Paul
  • Ghaemmaghami, Amir

Abstract

A microtopography system for modulating one or more cellular processes on a surface is described. The microtopography system comprising: a repeated microtopographic pattern, said microtopographic pattern comprising: an array of repeated micropillars applied to a surface of a product, said micropillars being formed of surface structures between 1-100 μm in height, and 1-50 μm in width. The microtopographic pattern acts to modulate one or more cellular processes on the surface.

IPC Classes  ?

  • C12M 1/00 - Apparatus for enzymology or microbiology
  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
  • B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

64.

DRUG FORMULATIONS

      
Application Number GB2021050227
Publication Number 2021/156607
Status In Force
Filing Date 2021-02-02
Publication Date 2021-08-12
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • He, Yinfeng
  • Wildman, Ricky
  • Roberts, Clive
  • Irvine, Derek
  • Mantovani, Giuseppe
  • Hague, Richard
  • Tuck, Christopher
  • Taresco, Vincenzo

Abstract

The invention relates to methods of producing solid drug formulations using advanced manufacturing techniques, such as 3D printing, where there is a requirement for low viscosity. The invention uses a photo-reactive material in liquid form, the photo-reactive material comprising: (a) prodrug monomer that comprises an active pharmaceutical ingredient in a prodrug form, in which the active pharmaceutical ingredient is releasably attached to a polymerisable group via a releasable covalent bond, and, optionally, (b) diluent monomer that comprises a polymerisable group.

IPC Classes  ?

  • A61K 9/20 - Pills, lozenges or tablets
  • A61L 27/14 - Macromolecular materials
  • A61L 27/54 - Biologically active materials, e.g. therapeutic substances
  • B33Y 10/00 - Processes of additive manufacturing
  • B33Y 80/00 - Products made by additive manufacturing

65.

Optically switchable memory

      
Application Number 17270279
Grant Number 11950520
Status In Force
Filing Date 2019-08-19
First Publication Date 2021-08-05
Grant Date 2024-04-02
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Kemp, Neil

Abstract

A method of manufacturing a storage device for storing information, apparatus for storing information, an optical memristor device and a memory cell are disclosed. A method comprises providing at least one first electrode and at least one further electrode and providing each of at least one region of a first material between, and in electrical connection with, a respective first electrode and a further electrode whereby said step of providing at least one region comprises providing in the first material, a plurality of changeable particles that have charge storage capacity and at least one electrical property that is reversibly changeable responsive to absorption of incident electromagnetic radiation.

IPC Classes  ?

  • H10N 70/20 - Multistable switching devices, e.g. memristors
  • G06N 3/08 - Learning methods
  • H10B 63/00 - Resistance change memory devices, e.g. resistive RAM [ReRAM] devices
  • H10N 70/00 - Solid-state devices having no potential barriers, and specially adapted for rectifying, amplifying, oscillating or switching

66.

CORNEAL TISSUE

      
Application Number GB2020052906
Publication Number 2021/094780
Status In Force
Filing Date 2020-11-13
Publication Date 2021-05-20
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Sidney, Laura
  • Hopkinson, Andrew
  • Mcintosh, Owen

Abstract

The invention provides an isolated dehydrated corneal tissue, comprising a full thickness corneal stroma, and substantially all, or all, of the Bowman's membrane, wherein the stroma contains cellular material. Also provided is a method to product the tissue and uses of the tissue.

IPC Classes  ?

  • A61F 2/14 - Eye parts, e.g. lenses or corneal implantsArtificial eyes
  • A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
  • C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

67.

SOCE FACILITATORS FOR USE IN TREATING OR PREVENTING VIRAL INFECTIONS

      
Application Number 17045083
Status Pending
Filing Date 2019-04-04
First Publication Date 2021-05-20
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Chang, Kin-Chow
  • Goulding, Leah Victoria

Abstract

The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) wherein R1-R11, X, Y and Q are as defined herein. Also provided are pharmaceutical compositions and combinations comprising such agents. An in vitro method of evaluating the antiviral activity or potential antiviral activity of a compound against a virus is also provided.

IPC Classes  ?

  • A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
  • A61K 31/015 - Hydrocarbons carbocyclic
  • A61K 31/19 - Carboxylic acids, e.g. valproic acid
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

68.

ANTIVIRAL COMPOUNDS AND METHODS

      
Application Number GB2020052479
Publication Number 2021/069891
Status In Force
Filing Date 2020-10-07
Publication Date 2021-04-15
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Chang, Kin-Chow
  • Hayes, Christopher, James
  • Gershkovich, Pavel

Abstract

The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) or (la) wherein R1-R4, A and B are as defined herein. Also provided are pharmaceutical compositions and combinations comprising such agents.

IPC Classes  ?

  • A61K 31/19 - Carboxylic acids, e.g. valproic acid
  • A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
  • A61K 31/365 - Lactones
  • A61P 31/12 - Antivirals
  • A61P 31/14 - Antivirals for RNA viruses
  • A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
  • C07C 67/28 - Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
  • C07C 69/21 - Acetic acid esters of hydroxy compounds with more than three hydroxy groups
  • C07C 69/33 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
  • C07C 69/533 - Monocarboxylic acid esters having only one carbon-to-carbon double bond
  • C07D 307/93 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
  • A61K 31/13 - Amines, e.g. amantadine
  • A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
  • A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
  • A61K 31/4965 - Non-condensed pyrazines
  • A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
  • A61K 31/7012 - Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid

69.

MAGNETIC SHIELD

      
Application Number GB2020052275
Publication Number 2021/053356
Status In Force
Filing Date 2020-09-18
Publication Date 2021-03-25
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Fromhold, Mark
  • Bowtell, Richard
  • Brookes, Matthew
  • Packer, Michael
  • Sims, Dominic
  • Hobson, Peter

Abstract

A method of designing a magnetic shield comprising a structure enclosing a space, the structure comprising passive magnetic shielding material and a winding configured to produce a specified magnetic within the structure when current is passed through the winding, is disclosed. The method comprises determining an optimised configuration of the winding accounting for the presence of the passive magnetic shield material by implementing one or more boundary conditions at the surface of the passive magnetic shielding material.

IPC Classes  ?

  • H01F 27/36 - Electric or magnetic shields or screens

70.

WEAR-RESISTANT COATING

      
Application Number 16620178
Status Pending
Filing Date 2018-06-06
First Publication Date 2021-03-18
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Hussain, Tanvir
  • Murray, James

Abstract

A method of coating an object, the method comprising: preparing a suspension comprising graphene nanoplatelets and a ceramic material; and spraying the suspension onto the object using high velocity oxy-fuel, HVOF, spraying in which the suspension is introduced as a feedstock.

IPC Classes  ?

71.

REACTION APPARATUS

      
Application Number GB2020051946
Publication Number 2021/032957
Status In Force
Filing Date 2020-08-14
Publication Date 2021-02-25
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • George, Michael
  • Poliakoff, Martyn
  • Lee, Darren
  • Pickering, Stephen
  • Sharabi, Medhat

Abstract

An apparatus for carrying out chemical reactions is provided. The apparatus comprises a first reactor/reaction zone for carrying out a first chemical reaction and a second reactor/reaction zone for carrying out a second chemical reaction. Each reactor/reaction zone comprises: a) an inner surface and an outer surface which are spaced apart from each other to define a reaction volume configured such that, in use, a respective chemical reaction takes place in the reaction volume, and wherein the inner surface and outer surface are configured for relative rotation with respect to each other, (b) an inlet for introduction of a reagent to the reaction volume, and (b) an outlet through which a reaction product can leave the reaction volume. The reaction products of the first reactor/reaction zone comprise reagents of the second reactor/reaction zone.

IPC Classes  ?

  • B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
  • B01J 19/18 - Stationary reactors having moving elements inside

72.

Method for producing metallurgical coke from non-coking coal

      
Application Number 16966954
Grant Number 11242490
Status In Force
Filing Date 2019-02-06
First Publication Date 2021-02-11
Grant Date 2022-02-08
Owner
  • The University of Nottingham (United Kingdom)
  • Tata Steel Limited (India)
Inventor
  • Das, Bidyut
  • Chandra, Sanjay
  • Pal, Atanu Ranjan
  • Dash, Pratik Swarup
  • Sudan, Munish
  • Binner, Eleanor
  • Dodds, Christopher
  • Lester, Edward Henry
  • Williams, Orla
  • Kingman, Samuel

Abstract

The present disclosure relates to a method for producing metallurgical coke from non-coking coal. The method comprising, densifying, the non-coking coal to form pellets. The densified pellets will be placed in a microwave oven within plurality of bricks and are subjected for pyrolysis. For carrying our pyrolysis, the pellets are carried out by heating, the pellets in the microwave oven at a predetermined temperature under an inert atmosphere at atmospheric pressure, and then the pellets are cooled in the microwave oven under the inert atmosphere. This process coverts non-coking coal to the metallurgical coke in a quicker time, and without use of any susceptors.

IPC Classes  ?

  • C10B 53/08 - Destructive distillation, specially adapted for particular solid raw materials or solid raw materials in special form in the form of briquettes, lumps or the like
  • C10B 19/00 - Heating of coke ovens by electrical means

73.

IMPROVEMENTS IN OR RELATING TO PHOTOGRAMMETRY

      
Application Number GB2020051733
Publication Number 2021/019206
Status In Force
Filing Date 2020-07-21
Publication Date 2021-02-04
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Leach, Richard
  • Piano, Samanta
  • Sims-Waterhouse, Danny

Abstract

Photogrammetric analysis of an object 10 is carried out by capturing images of the object 10. Photogrammetric analysis requires the capture of multiple overlapping images of the object 10 from various camera positions exemplified by positions 1-5. These images are then processed to generate a three-dimensional (3D) point cloud representing the object in 3D space. A 3D model of the object is used to generate a model 3D point cloud. Based on the modelled point cloud and camera optics, the visibility of each point in the 3D point cloud is determined for a range of possible camera positions. The radial component of the camera is fixed by defining a shell 20 of suitable camera positions around the part and for each position on the defined shell, the quality as a function of camera position is calculated. This defines a density function over the potential camera positions. Initial camera positions are selected based on the density function subject to refinement based on the overall expected quality of the photogrammetric analysis. The process can be repeated for different numbers of camera positions so that the optimum balance of time and accuracy is achieved.

IPC Classes  ?

  • G01C 11/02 - Picture-taking arrangements specially adapted for photogrammetry or photographic surveying, e.g. controlling overlapping of pictures
  • G06T 7/55 - Depth or shape recovery from multiple images
  • G06K 9/20 - Image acquisition

74.

NON-INVASIVE BRAIN STIMULATION

      
Application Number IB2020056586
Publication Number 2021/005584
Status In Force
Filing Date 2020-07-13
Publication Date 2021-01-14
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Jackson, Stephen
  • Jackson, Georgina

Abstract

The present invention relates to an electrical nerve stimulator configured to deliver an electrical signal to a user to entrain Mu-band neural oscillations and/or Beta-band neural oscillations. The electrical nerve stimulator may be used in the treatment of neurological conditions associated with desynchronization of neural oscillations, such as Tourette's syndrome. The electrical nerve stimulator may be wearable on a wrist of a user, and may be configured to deliver rhythmic stimulation at a frequency falling within the same frequency range of Mu-band or Beta-band neural oscillations. The invention provides a convenient means of treating conditions such as Tourette's syndrome without the need for specialist medical equipment or facilities. Also disclosed is a method of delivering an electrical signal to a user to entrain Mu-band neural oscillations and/or Beta-band neural oscillations.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/18 - Applying electric currents by contact electrodes
  • A61N 1/04 - Electrodes

75.

ANONYMIZATION

      
Application Number GB2020051521
Publication Number 2020/260869
Status In Force
Filing Date 2020-06-24
Publication Date 2020-12-30
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Valstar, Michel
  • Brown, Anthony
  • Almaev, Timur

Abstract

A computing system comprising a generative neural network (100) is disclosed. The generative neural network (100) is configured to receive a plurality of input videos. Each input video comprises a face defining an identity. Each input video comprises a behaviour. Each input video comprises the same behaviour as each of the other input videos, and a different identity to each of the other input videos. The generative neural network (100) is also configured synthesize an output video from the input videos. The output video comprises a synthetic face defining a synthetic identity. The generative neural network has been trained, with a loss function, to preserve the behaviour of the input videos while generating the synthetic identity that is different from each identity of the input videos.

IPC Classes  ?

  • G06N 3/04 - Architecture, e.g. interconnection topology
  • G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
  • G06N 3/08 - Learning methods
  • G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

76.

Land deformation measurement

      
Application Number 16622653
Grant Number 11269072
Status In Force
Filing Date 2018-06-13
First Publication Date 2020-12-17
Grant Date 2022-03-08
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Sowter, Andrew

Abstract

A method of measuring land deformation over time using interferograms derived from synthetic aperture radar data. The method includes: acquiring radar images covering an area at different points in time; deriving interferograms from pairs of the images, each interferogram measuring phase difference between pixels of a respective pair of images; for each pixel of the interferograms: determining an average coherence value over all of the interferograms; and if the average value is less than a threshold, determining an adjusted average coherence value equal to or above the threshold by excluding one or more of the interferograms below the threshold, provided the number of remaining interferograms is not less than a preset minimum number for each pixel of each interferogram for which the average or adjusted average coherence value is above the threshold, deriving vertical movement from the phase difference; and deriving the map of land deformation from the vertical movement.

IPC Classes  ?

  • G01S 13/90 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging using synthetic aperture techniques
  • G06T 7/00 - Image analysis
  • G06T 7/60 - Analysis of geometric attributes

77.

QUANTUM GRAVIMETERS AND GRADIOMETERS

      
Application Number GB2020051434
Publication Number 2020/249974
Status In Force
Filing Date 2020-06-12
Publication Date 2020-12-17
Owner
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
  • UNIVERSITY OF VIENNA (Austria)
Inventor
  • Fuentes, Ivette
  • Rätzel, Dennis
  • Ibarra, Tupac Bravo
  • Bruschi, David Edward

Abstract

A method of measuring an acceleration using one or more trapped BECs and at least two atomic field modes within those BECs is described. A density distribution of at least one of the one or more BECs is modified by the acceleration, which leads to a change of the field modes' time evolution. The method comprises: selecting two modes that are differently affected by the acceleration; and measuring the acceleration-induced difference; and using the measured acceleration-induced difference to infer the acceleration. Also described is a method of measuring a field gradient using one or more trapped BECs. Each of the trapped BECs has a density distribution, and at least two atomic modes within those BECs, wherein the density distributions of the one or more BECs are modified by the field, which leads to a change of the atomic modes' time evolution. The method comprises selecting two atomic modes that are differently affected by the field; and measuring a field- induced difference between the selected atomic modes; and using the measured field- induced difference to infer a gradient of the field.

IPC Classes  ?

  • G01V 7/02 - Measuring gravitational fields or wavesGravimetric prospecting or detecting Details
  • G01P 15/08 - Measuring accelerationMeasuring decelerationMeasuring shock, i.e. sudden change of acceleration by making use of inertia forces with conversion into electric or magnetic values

78.

AN ELECTROCHEMICAL MACHINING DEVICE

      
Application Number GB2020051294
Publication Number 2020/240188
Status In Force
Filing Date 2020-05-28
Publication Date 2020-12-03
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Mitchell-Smith, Jonathon
  • Clare, Adam
  • Speidel, Alistair
  • Bisterov, Ivan

Abstract

An electrochemical machining device is provided for machining a surface of a workpiece. The electrochemical machining device includes a base unit and a portable machining unit. The machining unit includes a housing, a nozzle disposed within the housing and configured for dispensing an electrolyte jet towards a surface of a workpiece. The machining unit is connected to the base unit via an umbilical cord for supplying power to the machining unit and for supplying electrolyte to the nozzle. The electrochemical machining device is applies a charge to the nozzle and a surface of a workpiece such that the nozzle and said surface define first and second electrodes of an electrolytic cell, in use. The nozzle is arranged so as to be spaced apart from a surface of a workpiece, in use.

IPC Classes  ?

  • C25F 7/00 - Constructional parts, or assemblies thereof, of cells for electrolytic removal of material from objectsServicing or operating

79.

THERAPEUTIC COMPOUNDS

      
Application Number GB2020051306
Publication Number 2020/240199
Status In Force
Filing Date 2020-05-29
Publication Date 2020-12-03
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Stevens, Malcolm
  • Bradshaw, Tracey
  • Moody, Christopher
  • Summers, Helen

Abstract

22A22, where each R' is independently selected from hydrogen and methyl.

IPC Classes  ?

  • A61P 35/00 - Antineoplastic agents
  • C07D 487/04 - Ortho-condensed systems
  • A61K 31/4188 - 1,3-Diazoles condensed with heterocyclic ring systems, e.g. biotin, sorbinil

80.

METHODS RELATING TO TUBERCULOSIS

      
Application Number GB2020050524
Publication Number 2020/234555
Status In Force
Filing Date 2020-03-05
Publication Date 2020-11-26
Owner
  • PBD BIOTECH LIMITED (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Swift, Benjamin
  • Rees, Catherine

Abstract

The invention relates to a method of diagnosis of tuberculosis (TB)disease in asubject. The method comprises admixing a Mycobacteria-specific bacteriophage with asample of peripheral blood mononuclear cells(PBMCs) from the subject, followed by determination of the presence or absence of a Mycobacterial DNA sequence in DNA isolated from the admixture. The invention provides a sensitive and specific test for the presence of incipient TB, i.e. an asymptomatic infectionwith a high risk of developing active TB, or for the presence oflatent tuberculosis infection(LTBI), i.e. an asymptomatic infection that is not likely to develop into active TB, in a subject.

IPC Classes  ?

  • C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
  • C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

81.

BROADBAND FILTER

      
Application Number IB2020054227
Publication Number 2020/225718
Status In Force
Filing Date 2020-05-04
Publication Date 2020-11-12
Owner
  • THE THINKING POD INNOVATIONS LTD (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Zhang, Zhe
  • Espina, Jordi
  • Johnson, Mark

Abstract

The present disclosure relates to a broadband filter for confining or attenuating electromagnetic interference noise from one or more electrical signal sources, In an embodiment, the broadband filter comprises one or more filter stages electrically coupled by galvanic or by electromagnetic means to the one or more electrical signal sources for confining or attenuating conducted electromagnetic interference noise; one or more conductive shields electrically coupled by galvanic or by electromagnetic means to the electrical signal sources wherein the shields encapsulate the filter stages for confining or attenuating conducted and/or radiated electromagnetic interference noise; and one or more conductive partition layers to encapsulate the one or more filter stages such that the partition layers electromagnetically couple adjacent filter stages for a selected frequency range of the electromagnetic interference noise. The thickness of the conductive partition layers is chosen to control the degree of coupling.

IPC Classes  ?

  • H03H 1/00 - Constructional details of impedance networks whose electrical mode of operation is not specified or applicable to more than one type of network
  • H05K 1/02 - Printed circuits Details
  • H05K 9/00 - Screening of apparatus or components against electric or magnetic fields
  • H02M 1/44 - Circuits or arrangements for compensating for electromagnetic interference in converters or inverters

82.

FUNGAL STRAINS, PRODUCTION AND USES THEREOF

      
Application Number EP2020060793
Publication Number 2020/212541
Status In Force
Filing Date 2020-04-16
Publication Date 2020-10-22
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Dyer, Paul

Abstract

PenicilliumPenicilliumPenicilliumPenicillium strains in various end applications.

IPC Classes  ?

83.

ENHANCED TRANSFECTION

      
Document Number 03134478
Status Pending
Filing Date 2020-03-23
Open to Public Date 2020-09-24
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Dixon, James

Abstract

The invention relates to a method of transfecting a cell with a molecule, the method comprising the steps of: adding a molecule for transfection to the cells; and modulating the activity of protein kinase C (PKC) in the cell and/or providing a pH responsive peptide comprising between about 5 and about 20 histidine residues; and related compositions and uses in therapy.

IPC Classes  ?

  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
  • C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

84.

ENHANCED TRANSFECTION

      
Application Number GB2020050766
Publication Number 2020/188302
Status In Force
Filing Date 2020-03-23
Publication Date 2020-09-24
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor Dixon, James

Abstract

The invention relates to a method of transfecting a cell with a molecule, the method comprising the steps of: adding a molecule for transfection to the cells; and modulating the activity of protein kinase C (PKC) in the cell and/or providing a pH responsive peptide comprising between about 5 and about 20 histidine residues; and related compositions and uses in therapy.

IPC Classes  ?

  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
  • C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

85.

Hat and monitoring system

      
Application Number 16082105
Grant Number 11957485
Status In Force
Filing Date 2017-03-03
First Publication Date 2020-09-10
Grant Date 2024-04-16
Owner
  • SUREPULSE MEDICAL LIMITED (United Kingdom)
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Carpenter, James
  • Hayes-Gill, Barrie
  • Henry, Caroline
  • Sharkey, Don
  • Shipley, Lara

Abstract

A hat (200) for a neonate (120) comprising: a central portion (201), a first side portion (202) and second side portion (203) attached to opposite sides of the central portion (201), a first fastener (208); a top flap (204) and a second fastener (211). The hat (200) has an unfolded configuration and a worn configuration. In the unfolded configuration the first and second portions (202, 203) extend away from each other from the central portion (201) in opposite directions. In the worn configuration the hat (200) wraps a neonate's head with the central portion (201) in contact with the back of the neonate's head, the first portion (202) wrapped around a first side of the neonate's head and the second portion (203) wrapped around a second side of the neonate's head. The first and second portions (202, 203) are configured to be fastened together in the worn configuration by the first fastener (208) so that the first portion (202), central portion (201) and second portion (203) together define a hat (214) rim encircling the neonate's head. The top flap (204) is configured to cover the top of the neonate's head in the worn configuration. The top flap (204) is configured to be fastened to at least one of the first, central and second portions (202, 201, 203) by the second fastener (211). The hat (200) further comprises an optical physiological sensor that comprises: a flexible circuit board, a light emitter (310) and a light detector (311); the flexible circuit board having: a sensor portion (302) to which the light emitter (310) and light detector (311) are connected; a module portion (305) including contacts (304) for electrically connecting the light emitter (310) and light detector (311) to a removable readout module (400); and an elongate lead portion (301) between the sensor portion (302) and module portion (305).

IPC Classes  ?

  • A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/024 - Measuring pulse rate or heart rate
  • A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
  • A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
  • A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]

86.

Heterocyclyl substituted pyrrolopyridines that are inhibitors of the CDK12 kinase

      
Application Number 16649512
Grant Number 11407767
Status In Force
Filing Date 2018-09-21
First Publication Date 2020-08-06
Grant Date 2022-08-09
Owner The University of Nottingham (United Kingdom)
Inventor
  • Brook, David
  • Hayes, Chris
  • Bennett, Nicholas
  • Palframan, Matthew
  • Cramp, Sue
  • Bull, Richard
  • Bodnarchuk, Michael

Abstract

4c are as defined herein.

IPC Classes  ?

  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
  • C07D 471/04 - Ortho-condensed systems
  • C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
  • A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
  • A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
  • A61P 35/04 - Antineoplastic agents specific for metastasis

87.

GENETIC CONSTRUCT AND USES THEREOF

      
Application Number GB2020050196
Publication Number 2020/157487
Status In Force
Filing Date 2020-01-28
Publication Date 2020-08-06
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Minton, Nigel
  • Blasco, Ines Canadas
  • Groothuis, Daphne
  • Zygouropoulou, Maria

Abstract

A spore-forming cell comprising a first nucleotide sequence encoding a riboswitch and a transcriptional activator, wherein the riboswitch modulates translation of the transcriptional activator in response to a First inducer, and a second nucleotide sequence encoding a target gene that regulates spore formation, wherein the target gene is expressed in response to a second inducer and translation of the transcriptional activator. Also provided is a method of culturing a spore-forming cell and a method of creating a spore, as well as uses of spore-forming cells and spores.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
  • C12N 15/67 - General methods for enhancing the expression
  • A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes

88.

GENETIC CONSTRUCT

      
Application Number GB2020050192
Publication Number 2020/157483
Status In Force
Filing Date 2020-01-28
Publication Date 2020-08-06
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Minton, Nigel
  • Blasco, Ines Canadas
  • Groothuis, Daphne
  • Zygouropoulou, Maria

Abstract

A genetic construct comprising a DNA polynucleotide sequence which encodes a riboswitch operably linked to a coding region, wherein the coding region encodes a target gene and the riboswitch modulates translation or transcription of the coding region. A vector or a host cell comprising the genetic construct of the invention. A method of controlling expression of a target gene in a cell using the genetic construct of the invention.

IPC Classes  ?

  • C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
  • C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

89.

Antibacterial compounds

      
Application Number 16493870
Grant Number 11192888
Status In Force
Filing Date 2018-03-16
First Publication Date 2020-06-25
Grant Date 2021-12-07
Owner The University of Nottingham (United Kingdom)
Inventor
  • Chan, Weng Choon
  • Genapathy, Sivaneswary
  • Yang, Lei

Abstract

Clostridium difficile, and a pharmaceutical composition containing the novel compound.

IPC Classes  ?

  • C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
  • A61P 31/04 - Antibacterial agents
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

90.

ISLET CELL ENGRAFTMENT

      
Application Number GB2019053291
Publication Number 2020/104802
Status In Force
Filing Date 2019-11-20
Publication Date 2020-05-28
Owner
  • THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
  • UNIVERSITY OF EDINBURGH (United Kingdom)
Inventor
  • Shakesheff, Kevin
  • Qutachi, Omar
  • Forbes, Shareen
  • Forbes, Stuart

Abstract

A composition of polymer particles, wherein the polymer particles are loaded with an agent that is capable of enhancing the binding of islet cells to liver tissue, and wherein (i) the polymer particles comprise linked molecules, wherein the linked molecules comprise:a) asialoglycoprotein receptor (ASGPR)-binding molecules that are capable of binding the asialoglycoprotein receptor (ASGPR) on a cell surface, orb) a binding- molecule that is specific for a cell surface marker that is predominantly present in liver tissue; and/or (ii) the polymer particles are between about 0.5 and about 100 microns in diameter.

IPC Classes  ?

  • A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
  • A61K 35/407 - LiverHepatocytes
  • A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

91.

USE OF 4-(BENZOTHIAZOLE-2-YL)ARYLAMINE COMPOUND IN TREATING STOMACH CANCER

      
Application Number CN2019115183
Publication Number 2020/098516
Status In Force
Filing Date 2019-11-02
Publication Date 2020-05-22
Owner
  • UNIVERSITY OF NOTTINGHAM (United Kingdom)
  • KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
  • JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (China)
Inventor
  • Bradshaw, Tracey, D.
  • Stevens, Malcolm, F., G.
  • Zhang, Jihong
  • Wang, Yuling
  • Shi, Dongfang
  • Cheng, Xi

Abstract

Disclosed is the use of a 4-(benzothiazole-2-yl)arylamine compound in treating stomach cancer, wherein the compound is a compound as shown in general formula I or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

92.

MAGNETIC OPTIMISATION

      
Application Number GB2019053182
Publication Number 2020/099842
Status In Force
Filing Date 2019-11-11
Publication Date 2020-05-22
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Fromhold, Mark
  • Welch, Nathan
  • Sims, Dominic
  • Ferreras, Jorge
  • Taylor, Ian

Abstract

A method of designing at least one coil for producing a magnetic field is disclosed. The method comprises: i) setting a performance target comprising: a target magnetic field, and at least two of a target power, a target resistance, a target size and/or weight, a target supply voltage or current, and a target inductance; ii) determining initial design parameters for the at least one coil; iii) modelling performance with the current design parameters to determine a simulated performance against each of the performance targets; iv) calculating a penalty function based on the difference between the simulated performance and the performance targets; v) modifying the design parameters in order to reduce the penalty function; vi) iterating steps iii) to v) until the penalty function or simulated performance has met an acceptance condition.

IPC Classes  ?

  • G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
  • H01F 5/00 - Coils

93.

SURFACE TOPOGRAPHY SENSING

      
Application Number GB2019052876
Publication Number 2020/074901
Status In Force
Filing Date 2019-10-10
Publication Date 2020-04-16
Owner UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Leach, Richard
  • Senin, Nicola

Abstract

A surface topography sensing apparatus (10) comprises a light source (11) operable to generate a reference light beam (12) which is incident upon a surface (1). The scattered reference light (13) is captured by a light detector (14), thereby capturing a characteristic angular scattering distribution (ASD) for the point where the beam (12) scatters from surface (1). The ASD is generated by a processing module (16) connected to the light detector (14). Once the ASD is generated, the processing module 16 is operable to compare the generated ASD against a library (17) of sample ASDs, each sample ASD representative of a particular expected surface topography condition for the specific application being studied. Based on the comparison, the processing module may then assign a classification of the topography of surface (1).

IPC Classes  ?

  • G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
  • G01B 11/30 - Measuring arrangements characterised by the use of optical techniques for measuring roughness or irregularity of surfaces

94.

RAMAN SPECTROSCOPY METHOD AND APPARATUS

      
Application Number GB2019052618
Publication Number 2020/058702
Status In Force
Filing Date 2019-09-17
Publication Date 2020-03-26
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Notingher, Ioan
  • Corden, Christopher
  • Shipp, Dustin

Abstract

The disclosure relates to Raman spectroscopy, in particular to apparatus and methods for acquisitions of a Raman spectral map of a sample. Example embodiments disclosed include an apparatus (100) for acquiring a Raman spectral map (101) of a sample (108) comprising a material species, the Raman spectral map (101) consisting of an array of data points corresponding to respective regions of the sample (108), the apparatus (100) comprising: a pulsed illumination source (102) arranged to provide pulsed illumination radiation (104) for exciting the sample (108) and producing scattered radiation; a microscope objective (106) arranged to focus the pulsed illumination radiation (104) onto a region of the sample (108) corresponding to a data point of the Raman spectral map (101), and further arranged to collect emitted radiation (114) from said region; a translation stage (112) arranged to translate the sample (108) relative to the microscope objective (106) in at least two directions; a spectral filter (130) arranged to spectrally filter the emitted radiation collected by the microscope objective (106) to obtain a filtered portion (132) of the emitted radiation (114) corresponding to one or more characteristic Raman spectral features of the material species; a detector (134) arranged to receive said filtered portion (132) of the emitted radiation (114) and to provide output electrical pulses indicative thereof; and readout electronics (146) connected to the detector (134) and operable to apply a time gate to said output electrical pulses to distinguish detection events corresponding to Raman scattered radiation associated with the material species from detection events associated with photoluminescence.

IPC Classes  ?

  • G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
  • G01J 3/44 - Raman spectrometryScattering spectrometry
  • G01J 3/12 - Generating the spectrumMonochromators

95.

MONITORING PHYSIOLOGICAL PARAMETERS

      
Application Number GB2019052454
Publication Number 2020/049291
Status In Force
Filing Date 2019-09-03
Publication Date 2020-03-12
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Morgan, Stephen
  • Hayes-Gill, Barrie
  • Korposh, Serhiy
  • Correia, Ricardo

Abstract

The present invention relates to a system (100) for monitoring one or more physiological parameters of an individual. The system (100) comprises an optical fibre assembly (110) configured to measure one or more physiological parameters of an individual, and a pressure sensor (120) configured to measure a contact pressure of the optical fibre assembly (110) on the individual. The pressure sensor (120) comprises an optical fibre (122) comprising a transducer fibre Bragg grating (127) embedded in a matrix (121). The matrix (121) is configured to cause longitudinal strain in the transducer fibre Bragg grating (127) in response to the matrix (121) being subject to a transverse load. The one or more physiological parameters that the system (100) is for monitoring may include blood oxygen saturation (Sp O2), capillary refill time (CRT), heart rate, blood flow and CO2 emissions from skin.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A61B 5/024 - Measuring pulse rate or heart rate

96.

Glycolipids and pharmaceutical compositions thereof for use in therapy

      
Application Number 16522216
Grant Number 11248016
Status In Force
Filing Date 2019-07-25
First Publication Date 2019-12-19
Grant Date 2022-02-15
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Bottley, Andrew
  • Hayes, Christopher
  • Seymour, Graham
  • Grabowska, Anna
  • Clarke, Philip

Abstract

The invention may provide, in part, compounds for use as antiproliferative, chemotherapeutic, antiviral, cell sensitising or adjuvant agents, and pharmaceutical compositions including the compounds. The compounds may be for use in treating diseases and disorders related to cell proliferation such as cancer, or in treating diseases and disorder which are linked to aberrant control of protein synthesis, such as cancer, viral infection, muscle wasting, autistic spectrum disorders, Alzheimer's disease, Huntingdon's disease and Parkinson's disease.

IPC Classes  ?

  • C07H 15/06 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical being a hydroxyalkyl group esterified by a fatty acid
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 31/7032 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
  • A61K 33/243 - PlatinumCompounds thereof
  • A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
  • A23L 33/16 - Inorganic salts, minerals or trace elements

97.

TARGETED MODIFICATION OF MAIZE ROOTS TO ENHANCE ABIOTIC STRESS TOLERANCE

      
Application Number 16554345
Status Pending
Filing Date 2019-08-28
First Publication Date 2019-12-19
Owner
  • Wisconsin Alumni Research Foundation (USA)
  • The Penn State Research Foundation (USA)
  • The University of Nottingham (United Kingdom)
Inventor
  • Kaeppler, Shawn Michael
  • Saengwilai, Patompong
  • Lynch, Jonathan Paul
  • Bennett, Malcolm John
  • Johnson, James

Abstract

The present invention relates to crop breeding. More particularly, the present invention relates to targeted modification of root to enhance abiotic stress tolerance in maize. In one aspect, the invention provides recombinant maize exhibiting increased root cortical aerenchyma (RCA). Methods of making the recombinant maize and various methods of plant selection and breeding are further provided.

IPC Classes  ?

  • A01H 5/10 - Seeds
  • C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
  • C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
  • A01H 6/46 - Gramineae or Poaceae, e.g. ryegrass, rice, wheat or maize

98.

SOCE FACILITATORS FOR USE IN TREATING OR PREVENTING VIRAL INFECTIONS

      
Application Number GB2019050977
Publication Number 2019/193343
Status In Force
Filing Date 2019-04-04
Publication Date 2019-10-10
Owner THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
  • Chang, Kin-Chow
  • Goulding, Leah Victoria

Abstract

The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) wherein R1-R11in vitroin vitro method of evaluating the antiviral activity or potential antiviral activity of a compound against a virus is also provided.

IPC Classes  ?

  • A61K 31/365 - Lactones
  • A61K 31/015 - Hydrocarbons carbocyclic
  • A61K 31/13 - Amines, e.g. amantadine
  • A61K 31/19 - Carboxylic acids, e.g. valproic acid
  • A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
  • A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
  • A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
  • A61K 31/7012 - Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61K 9/12 - AerosolsFoams
  • G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • A61P 31/14 - Antivirals for RNA viruses
  • A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
  • A61P 31/12 - Antivirals

99.

Mixing reactor and related process

      
Application Number 16426760
Grant Number 10722860
Status In Force
Filing Date 2019-05-30
First Publication Date 2019-09-12
Grant Date 2020-07-28
Owner The University of Nottingham (United Kingdom)
Inventor
  • Lester, Edward
  • Huddle, Thomas

Abstract

A mixing reactor for precipitating nanoparticles by mixing a precursor fluid with a second fluid at a higher temperature than the precursor fluid. The reactor comprises: a first fluid conduit with an inlet region configured to receive a flow of the precursor fluid, and an outlet region configured to output a mixed flow; and a second fluid conduit configured to receive a flow of the second fluid. The second fluid conduit extends into the first fluid conduit in a direction substantially perpendicular to the flow within the first fluid conduit, and has an opening for introducing the second fluid into the first fluid conduit. Related processes for producing nanoparticles are disclosed.

IPC Classes  ?

  • B01J 3/00 - Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matterApparatus therefor
  • B01J 19/24 - Stationary reactors without moving elements inside
  • B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
  • B01F 5/04 - Injector mixers
  • B01F 5/06 - Mixers in which the components are pressed together through slits, orifices, or screens
  • B01J 4/00 - Feed devicesFeed or outlet control devices
  • B01F 15/06 - Heating or cooling systems
  • B01J 3/04 - Pressure vessels, e.g. autoclaves
  • C01G 49/06 - Ferric oxide [Fe2O3]
  • B01F 3/00 - Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed

100.

Additive manufacturing

      
Application Number 16405756
Grant Number 11179887
Status In Force
Filing Date 2019-05-07
First Publication Date 2019-08-29
Grant Date 2021-11-23
Owner The University of Nottingham (United Kingdom)
Inventor
  • Tuck, Christopher John
  • Begines Ruiz, Belén
  • He, Yinfeng
  • Wildman, Ricky Darren
  • Hague, Richard James Mackenzie

Abstract

a) have two or fewer reactive groups, and allowing (330) linear polymeric chains in said layer of polymeric material (100) to react with reactive units in said reactive liquid (200) so as to form extended polymeric chains that are linear, so as to provide a shaped layer of linear polymer. These steps (310, 320, 330) are repeated as required to form the object from successive shaped layers of linear polymer.

IPC Classes  ?

  • B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
  • B33Y 10/00 - Processes of additive manufacturing
  • B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
  • B33Y 70/00 - Materials specially adapted for additive manufacturing
  • B29C 64/20 - Apparatus for additive manufacturingDetails thereof or accessories therefor
  • B29K 75/00 - Use of polyureas or polyurethanes as moulding material
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