Stabilised copper sub-micron scale particles are provided, which are suitable for use in the manufacture of an electrically conductive product. The particles have a mean diameter in the range of from 25nm to 1000nm, and each particle comprises (a) a metallic copper inner core and (b) a sulfated polymer outer layer. The particles can be compressed at room temperature to fabricate free-standing conductive copper films or can be deposited onto a substrate to form supported electrically conductive products.
H01B 1/02 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of metals or alloys
Disclosed herein is a computer-implemented method which comprises obtaining testing data comprising a plurality of medical images and at least one likelihood value associated with each image. The likelihood values have been assigned by a machine learning model. Each likelihood value is indicative of a likelihood that a feature in the associated image is a malignant feature. The method further comprises determining a first classification data set for the plurality of images by comparing, for each image, the at least one likelihood value to a decision threshold; comparing the first classification data set to a verified classification data set associated with the plurality of medical images; and determining, based on comparing the first classification data set to the verified classification data set, a performance score associated with the machine learning model.
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
A microtopography system for modulating one or more cellular processes on a surface is described. In particular a microtopography system comprising: a repeated microtopographic pattern and a polymer coating, said microtopographic pattern comprising: an array of repeated micropillars applied to a surface of a product, said micropillars being formed of surface structures between 1-100 μm in height, and 1-50 μm in width; and said polymer coating comprising one of a (meth)acrylate or (meth)acrylamide monomer, or mixture of two (meth)acrylate or (meth)acrylamide monomers. The microtopographic pattern and said polymer coating act to modulate one or more cellular processes on the surface.
The invention provides a decellularized tissue hydrogel cross-linked with a polyphenol, and a method of preparing a cross-linked decellularized tissue hydrogel, the method comprising the steps of: a) providing at least one decellularized tissue hydrogel; and b) cross-linking the at least one decellularized tissue hydrogel with a polyphenol.
A method of determining one or more properties of a sample, comprising: determining, at a plurality of generation sites of the sample, a plurality of acoustic velocity measurements, the plurality of acoustic velocity measurements using different acoustic propagation directions; and determining a best fit elasticity for the acoustic velocity measurements at different acoustic propagation directions at the plurality of generation sites, wherein determining a best fit elasticity comprises assuming a common elasticity for the plurality of generation sites while allowing crystallographic orientation to vary.
The invention relates to a nucleic acid molecule encoding a group II intron, wherein the group II intron encodes a retrotransposition-activated marker (RAM) and a counter-selection marker. The invention further relates to a nucleic acid molecule encoding: a first promoter operably-linked to a group II intron, wherein the group II intron does not encode a protein comprising reverse transcriptase activity, and a second promoter operably-linked to a nucleic acid sequence encoding an intron-encoded protein (IEP), wherein the group II intron encodes: a retrotransposition-activated marker (RAM), a counter-selection marker, and a targeting sequence; and related kits and methods.
An active magnetic shield system, including an array of magnetic field sensors arranged to sense a local magnetic field. An array of magnetic field elements are arranged produce a magnetic field. Each magnetic field element has a unit coil for mounting to a plurality of surfaces arranged in at least 3 planes to define an enclosed cancellation volume, and to produce a vector magnetic field pattern.
G01R 33/421 - Screening of main or gradient magnetic field
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
H05K 9/00 - Screening of apparatus or components against electric or magnetic fields
The invention relates to conductive nanoparticles, comprising an electron donor species and an electron acceptor species each attached to the nanoparticle, and pharmaceutical compositions comprising such nanoparticles. The invention also relates to use of the nanoparticles in modulating the biological activity of one or more cells such as cancer cells, and in treating cancer.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A wind turbine may be fitted with the facility store electricity indirectly using one or more thermal stores. The power-conversion machinery is installed within the wind turbine nacelle which rotates to point the turbine into the wind. The thermal storage is realised in the fixed frame – i.e. it does not rotate with the nacelle. The connection between the fixed frame and the rotatable frame is via one or more rotary heat exchangers. While the energy storage is charging, heat passes through the hot heat exchanger to a hot store or coldness passes through the cold heat exchanger to a cold store or both. During discharging, the opposite flows occur. Each rotary heat exchanger has a shell-and-tube configuration. The tube bundle rotates with the nacelle. The shell comprises one set of surfaces that does not rotate and one that does rotate.
A hat (200) for a neonate (120) comprising: a central portion (201), a first side portion (202) and second side portion (203) attached to opposite sides of the central portion (201), a first fastener (208); a top flap (204) and a second fastener (211). The hat (200) has an unfolded configuration and a worn configuration. In the unfolded configuration the first and second portions (202, 203) extend away from each other from the central portion (201) in opposite directions. In the worn configuration the hat (200) wraps a neonate's head with the central portion (201) in contact with the back of the neonate's head, the first portion (202) wrapped around a first side of the neonate's head and the second portion (203) wrapped around a second side of the neonate's head. The first and second portions (202, 203) are configured to be fastened together in the worn configuration by the first fastener (208) so that the first portion (202), central portion (201) and second portion (203) together define a hat (214) rim encircling the neonate's head. The top flap (204) is configured to cover the top of the neonate's head in the worn configuration. The top flap (204) is configured to be fastened to at least one of the first, central and second portions (202, 201, 203) by the second fastener (211). The hat (200) further comprises an optical physiological sensor that comprises: a flexible circuit board, a light emitter (310) and a light detector (311); the flexible circuit board having: a sensor portion (302) to which the light emitter (310) and light detector (311) are connected; a module portion (305) including contacts (304) for electrically connecting the light emitter (310) and light detector (311) to a removable readout module (400); and an elongate lead portion (301) between the sensor portion (302) and module portion (305).
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
Sorbents for carbon dioxide capture The present invention provides a sorbent for absorbing carbon dioxide from a gas or a mixture of gases comprising: (A) polyalkyleneimine or an alkoxylated polyalkyleneimine; and (B) an inorganic solid support for the polyalkyleneimine or alkoxylated polyalkyleneimine (A), in which the alkoxylated polyalkyleneimine (A) is located on the inorganic solid support (B), wherein the sorbent comprises water in an amount of greater than 2 wt. % based on the weight of the sorbent. The present invention also provides a process for preparing such a sorbent and additionally provides uses of the sorbent for capturing carbon dioxide from a mixture of gases, such as air.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
11010 alkyl group; an aryl group optionally substituted with at least one moiety selected from the group comprising: a halogen, a hydroxy group, a nitro group, an alkyl group, an alkoxy group or a nitrile group; an optionally substituted amine; an alkoxy group; an aryloxy group or a thio group, R1is hydrogen, an aryl group or an alkyl group, R2is hydrogen, an aryl group or an alkyl group, and R3is an aryl group, a nitrile group, a COOR4group or an OCOR4group, wherein R4 is an alkyl group.
The invention provides a lithium-sulfur battery comprising a positive electrode, a negative electrode and an electrolyte wherein the electrolyte comprises a solvent and at least one polyoxometalate compound wherein the at least one polyoxometalate compound is dissolved in the solvent.
A process for producing compositions comprising alkoxylated polyalkyleneimines, said compositions and their uses The present invention provides the use of a composition comprising alkoxylated polyalkyleneimine for capturing gases with a pKa greater than 5, preferably carbon dioxide, from a gas or mixture of gases, the composition being obtainable by a process for producing a composition comprising an alkoxylated polyalkyleneimine comprising the steps: (a) providing a reaction mixture comprising (i) a polyalkyleneimine; and (ii) an alkylene oxide; (b) carrying out a reaction between the (i) polyalkyleneimine and the (ii) alkylene oxide at a temperature of at least 50°C; and (c) optionally diluting the product of step (b), wherein the mole ratio of alkylene oxide to NH of the polyalkyleneimine in the reaction mixture is from 0.1 to 0.35, and wherein the reaction mixture comprises <55% water, preferably <30% water, based on the weight of the reaction mixture and the reaction mixture comprises less than 5%, preferably less than 1 %, of a polar organic solvent based on the weight of the reaction mixture. The invention also claims a new composition comprising an alkoxylated polyalkyleneimine, which is obtainable by the analogous process as above, in whichthe alkylene oxide comprises propylene oxide and/or butylene oxide. The process of producing the new composition is also claimed. The new composition has been found to be effective at capturing carbon dioxide from a mixture of gases, e.g. air.
B01D 53/00 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols
The invention provides a method for the preparation of 5-hydroxymethylfurfural or a derivative thereof and 2,5-furandicarboxylic acid comprising the step of biocatalytically converting at least one carbonaceous feedstock supplemented with glucose to 5-hydroxymethylfurfural or a derivative thereof and 2,5-furandicarboxylic acid also via intermediates like glyceraldehyde-3-phosphate and 4-hydroxymethyl-2-furancarboxaldehyde-phosphate using Streptomyces sp. S deposited as NCIMB 43995 and gene MfnB encoding (5-fromylfuran-3-yl)methyl phosphate synthase (EC 4.2.3.153) isolated from said strain.
The invention provides a chiral single stereoisomer diene of Formula (I) wherein R1, R2, and R3are each substituent groups that are independently selected from H, halogen groups, alkyl groups (which may be linear or branched), alkenyl groups (which may be linear or branched, and may in particular be allyl or methallyl), aryl groups, alkaryl groups, heteroaryl groups, and substituted amino groups, ether groups, or carbonyl groups; wherein each substituent group R may be optionally substituted; and wherein R1, R2, and R3HH)-one ligands according to the present invention may be used as ligands for metals in enantioselective catalysis and transition metal complexes of these ligands may in particular be used as catalyst in the manufacture of active pharmaceutical ingredients.
The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) or (Ia) wherein R1-R4, A and B are as defined herein. Also provided are pharmaceutical compositions and combinations comprising such agents.
The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) or (Ia) wherein R1-R4, A and B are as defined herein. Also provided are pharmaceutical compositions and combinations comprising such agents.
C07D 307/93 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
A61K 9/00 - Medicinal preparations characterised by special physical form
A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
C07C 69/24 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with monohydroxylic compounds
C07C 69/533 - Monocarboxylic acid esters having only one carbon-to-carbon double bond
C07C 69/675 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
nnn), each of the interferograms comprising a reflected light beam resulting from reflection of a light beam from at least one of the first face and the second face and each of the interferograms comprising a reflected light beam with reflections from a different combination and/or sequence of surfaces. The method further comprises performing a spatial frequency transform of the interference data to generate transformed data in a spatial frequency domain and analysing features of the transformed data to determine the optical path length, wherein each feature in the transformed data corresponds to one of the interferograms in the interference data and at least some of the features are at least partially separated in the spatial frequency domain.
An electric machine (100) comprising a rotor (130) and a stator (140), wherein at least one of the rotor (130) and/or stator (140) comprises a toroidal winding comprising a plurality of preformed conductors.
H02K 15/04 - Processes or apparatus specially adapted for manufacturing, assembling, maintaining or repairing of dynamo-electric machines of windings prior to their mounting into the machines
H02K 3/12 - Windings characterised by the conductor shape, form or construction, e.g. with bar conductors arranged in slots
H02K 3/24 - Windings characterised by the conductor shape, form or construction, e.g. with bar conductors with channels or ducts for cooling medium between the conductors
H02K 9/19 - Arrangements for cooling or ventilating for machines with closed casing and closed-circuit cooling using a liquid cooling medium, e.g. oil
21.
A SYSTEM AND METHOD FOR ESTIMATING TOTAL DISSOLVED SOLIDS IN BOILER WATER
A system (12) for estimating total dissolved solids (TDS) concentration in boiler water is described which comprises: a sensor (14) having a transmitter configured to transmit an RF or microwave signal into the boiler water and a receiver configured to receive a reflected signal from a reflection of the RF or microwave signal by the boiler water; and an analysis module (16) configured to determine a conductivity value for the boiler water based on the reflected signal and to determine a TDS concentration for the boiler water based on the conductivity. A corresponding method is also described.
G01N 22/00 - Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more
NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST (United Kingdom)
Inventor
Webb, Kevin
Moradi, Emilia
Foss, Alexander
Abstract
The invention provides a method of delivering a payload molecule across an epithelial tissue barrier, the method comprising: applying the payload molecule to the epithelial tissue barrier, and additionally applying an agent to the epithelial tissue barrier. The agent is (i) a microbial quorum sensing signalling molecule (microbial QSSM) or a derivative or variant thereof, which is capable of disrupting the epithelial tissue barrier function, or (ii) a carboxylic acid compound, or a pharmaceutically acceptable salt, hydrate or solvate thereof.
A61P 43/00 - Drugs for specific purposes, not provided for in groups
A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A method of reducing error in magnetoencephalography arising from the presence of a non-neuromagnetic field. The method comprises measuring, using a sensor array for measuring neuromagnetic fields, magnetic field at a plurality of discrete locations around a subject's head to provide sensor data; wherein the magnetic field measured at at least some of the locations includes a neuromagnetic field from a source of interest within a subject's brain and a non-neuromagnetic field from a source of no interest external to the brain. The measuring comprises: measuring, at at least a first subset of the locations, a magnetic field along a first direction relative to a radial axis intersecting the respective location, and measuring, at at least a second subset of the locations, a magnetic field along a second direction relative to a radial axis intersecting the respective location which is different to the first direction; and performing source reconstruction using the sensor data.
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
G01R 33/032 - Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday
The invention provides a macrocyclic compound of Formula (I): wherein each R1 is independently an aromatic ring system that is optionally substituted, and wherein n is an integer of from 2 to 50.
The invention provides the use of micro-scale three-dimensional objects on a surface, to influence the extent to which macrophage attachment occurs at the surface and/or the phenotype of macrophage that attaches to the surface. The invention provides a product, such as a healthcare implant, wherein micro- scale three-dimensional objects are provided on a surface of the product.
A process (1, 2) for processing feedstock containing cotton fibres and PET fibres, the process (1, 2) comprises: i. heating a suspension of feedstock containing cotton fibres and PET fibres in water at a temperature above 180° C. to produce a mixture comprising char; ii. removing the water from the mixture comprising char; iii. adding a base to the mixture comprising char to produce a terephthalate salt in a liquid phase; iv. removing the char from the liquid phase to produce dried char; v. acidifying the liquid phase to produce terephthalic acid.
C08J 11/14 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with steam or water
C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material
C07C 51/02 - Preparation of carboxylic acids or their salts, halides, or anhydrides from salts of carboxylic acids
C08J 11/06 - Recovery or working-up of waste materials of polymers without chemical reactions
bioBbioB), to enhance D-biotin biosynthesis. The invention also provides optimised methods of culturing the genetically engineered cells to produce D-biotin, recovering the D-biotin from cultivation media, and purifying the D-biotin.
C12P 17/18 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
The invention relates to novel compounds of formula (I), the compounds being capable of acting as avβ6 integrin antagonists, their use in the treatment of disease, their methods of manufacture and compositions comprising said compounds for such purposes (I) wherein R1 is selected from: R1a, —C(O)R1a, —C(O)OR1a —C(O)NHR1a, —C(O)N(R1a)2, —SO2R1a, wherein R1a are each independently selected from: alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl, each of which may be optionally substituted; R2 is selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R2a are each independently selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R3 is selected from: hydrogen, optionally substituted alkyl or optionally substituted alkoxyl; R4 is hydroxyl; Ar1 is an optionally substituted heteroaryl or bicyclic heteroaryl; and L is a linker; or a pharmaceutically acceptable salt thereof.
The invention relates to novel compounds of formula (I), the compounds being capable of acting as avβ6 integrin antagonists, their use in the treatment of disease, their methods of manufacture and compositions comprising said compounds for such purposes (I) wherein R1 is selected from: R1a, —C(O)R1a, —C(O)OR1a —C(O)NHR1a, —C(O)N(R1a)2, —SO2R1a, wherein R1a are each independently selected from: alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl, each of which may be optionally substituted; R2 is selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R2a are each independently selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R3 is selected from: hydrogen, optionally substituted alkyl or optionally substituted alkoxyl; R4 is hydroxyl; Ar1 is an optionally substituted heteroaryl or bicyclic heteroaryl; and L is a linker; or a pharmaceutically acceptable salt thereof.
A thermal spray system (50), a thermal spray nozzle (200) and a method of thermal spray coating are disclosed. The thermal spray system (50) comprises a combustion chamber (101) configured to produce a thermal spray flame (106) from the reaction product of a fuel fluid and an oxidiser fluid; a first feedstock injection port (107) configured to entrain a first feedstock material in the thermal spray flame (106); an inert gas injection port (202) configured to shroud the thermal spray flame (106) with an inert gas; and a second feedstock injection port (207) configured to entrain a second feedstock material in the thermal spray flame (106). The first feedstock injection port (107) is spaced apart from the second feedstock injection port (207) along a longitudinal axis of the thermal spray flame (106).
An apparatus for processing a material is disclosed. The apparatus comprises a toroidal bed chamber (110) and a waveguide (120). The toroidal bed chamber (110) has chamber walls comprising an inner sidewall (111), an outer sidewall (112) and a base (113), the inner sidewall (111), outer sidewall (112) and base (113) at least partly defining a toroidal volume for material to circulate within. A circulation fluid inlet (130) is provided for introducing a circulation fluid (131) with a velocity component tangential to the toroidal volume for causing the material to circulate within the toroidal volume. The waveguide (120) is for receiving microwave radiation and communicating the microwave radiation to interior of the toroidal bed chamber. The waveguide (120) comprises at least one microwave transparent window (121) in the inner sidewall (111), the outer sidewall (112) or the base (113).
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
A coating for a transmissive optical component of an optical sensor comprises tetrakis(4-sulfophenyl)porphine (TSPP) crosslinked with a diazo resin (DAR). The coating may comprise alternate layers of (a) DAR and (b) a mixture of TSPP and poly(styrene sulfonate) (PSS). An optical sensor is provided for detecting an analyte that modifies the absorption spectrum of TSPP. The sensor comprises a transmissive optical component, a light source at an input side of the optical component and a detector for detecting light at at least one frequency at an output side of the optical component. The optical component has a coating as mentioned above.
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
The invention provides particulate material suitable for use in manufacturing a three-dimensional object, the material comprising a plurality of particles. Each particle has a thermoplastic polymeric core; and a polymeric shell that coats the polymeric core. The polymeric core makes up 75wt% or more of each particle. The polymeric shell is formed from a co-polymer of a major monomer and a minor monomer, wherein the major monomer comprises a polymerisable group, and the minor monomer comprises (i) a polymerisable group; and (ii) a functional component, and wherein the co-polymer is formed by reaction of the polymerisable group on the major monomer with the polymerisable group on the minor monomer.
A microtopography system for modulating one or more cellular processes on a surface is described. The microtopography system comprising: a repeated microtopographic pattern, said microtopographic pattern comprising: an array of repeated micropillars applied to a surface of a product, said micropillars being formed of surface structures between 1-100 μm in height, and 1-50 μm in width. The microtopographic pattern acts to modulate one or more cellular processes on the surface.
A number of different sealed interfaces for power modules are described. In one example, a sealed interface includes a printed circuit board including a contact pad for power conduction to a bus bar of the printed circuit board, a semiconductor module including at least one power transistor, a terminal pin electrically coupled to the power module, and a housing for the power module. The housing includes an open terminal aperture that extends through the housing. The printed circuit board is seated upon the open terminal aperture, to close and seal the open terminal aperture, with the contact pad positioned within the open terminal aperture. The terminal pin contacts the contact pad of the printed circuit board within the open terminal aperture, and the open terminal aperture comprises a transitional feature to abate electric field intensity around an interface between the open terminal aperture and the printed circuit board.
A method of determining one or more properties of a sample, comprising: determining, at a plurality of generation sites of the sample, a plurality of acoustic velocity measurements, the plurality of acoustic velocity measurements using different acoustic propagation directions; and determining a best fit elasticity for the acoustic velocity measurements at different acoustic propagation directions at the plurality of generation sites, wherein determining a best fit elasticity comprises assuming a common elasticity for the plurality of generation sites while allowing crystallographic orientation to vary.
A method for preparing an atomically dispersed metal catalyst, comprising: depositing atomically dispersed metal onto a support by magnetron sputtering to directly form a catalyst comprising metal particles, with mean diameter up to 1 nm, dispersed on the surface of the support, wherein the support is water insoluble.
The invention provides an isolated dehydrated corneal tissue, comprising a full thickness corneal stroma, and substantially all, or all, of the Bowman's membrane, wherein the stroma contains cellular material. Also provided is a method to product the tissue and uses of the tissue.
A method of designing a magnetic shield comprising a structure enclosing a space, the structure comprising passive magnetic shielding material and a winding configured to produce a specified magnetic within the structure when current is passed through the winding, is disclosed. The method comprises determining an optimised configuration of the winding accounting for the presence of the passive magnetic shield material by implementing one or more boundary conditions at the surface of the passive magnetic shielding material.
An active magnetic shield system, comprising an array of magnetic field sensors arranged to sense a local magnetic field. An array of magnetic field elements are arranged produce a magnetic field. Each magnetic field element has a unit coil for mounting to a plurality of surfaces arranged in at least 3 planes to define an enclosed cancellation volume, and to produce a vector magnetic field pattern.
The invention provides a decellularized tissue hydrogel cross-linked with a polyphenol, and a method of preparing a cross-linked decellularized tissue hydrogel, the method comprising the steps of: a) providing at least one decellularized tissue hydrogel; and b) cross-linking the at least one decellularized tissue hydrogel with a polyphenol.
Photogrammetric analysis of an object is carried out by capturing images of the object. Photogrammetric analysis requires the capture of multiple overlapping images of the object from various camera positions. These images are then processed to generate a three-dimensional (3D) point cloud representing the object in 3D space. A 3D model of the object is used to generate a model 3D point cloud. Based on the modelled point cloud and camera optics, the visibility of each point in the 3D point cloud is determined for a range of possible camera positions. The radial component of the camera is fixed by defining a shell of suitable camera positions around the part and for each position on the defined shell, the quality as a function of camera position is calculated. This defines a density function over the potential camera positions. Initial camera positions are selected based on the density function.
Glycosaminoglycans (GAGs) are important biopolymers that differ in the sequence of saccharide units, and in post-polymerization alterations at various positions, making these molecules complex and challenging to analyse. We have developed an approach that enables small quantities (< 200 ng) of hundreds of different GAGs to be analysed within a short time frame (3-4 hours). Time of flight secondary ions mass spectrometry 10 together with multivariate analysis was used to analyse an array of over 400 GAG samples. Resultant spectra were derived from the whole molecules and did not require pre-digestion. All 6 GAG types were successfully discriminated, both alone and in the presence of fibronectin. We also distinguished between pharmaceutical grade heparin derived from different animal species and from different suppliers to a sensitivity as 15 low as 0.001 wt%. This approach is highly beneficial in the quality control of GAGs produced for therapeutic applications and for characterising GAGs within biomaterials or from in vitro cell culture.
An apparatus for carrying out chemical reactions is provided. The apparatus comprises a first reactor/reaction zone for carrying out a first chemical reaction and a second reactor/reaction zone for carrying out a second chemical reaction. Each reactor/reaction zone comprises: a) an inner surface and an outer surface which are spaced apart from each other to define a reaction volume configured such that, in use, a respective chemical reaction takes place in the reaction volume, and wherein the inner surface and outer surface are configured for relative rotation with respect to each other, (b) an inlet for introduction of a reagent to the reaction volume, and (b) an outlet through which a reaction product can leave the reaction volume. The reaction products of the first reactor/reaction zone comprise reagents of the second reactor/reaction zone.
B01J 19/18 - Stationary reactors having moving elements inside
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
The present application relates to a chemical sensor (100), comprising: an optical fibre (110); an optical cavity, optically coupled to the optical fibre (110), wherein the optical cavity comprises a dye with an absorbance and/or fluorescence spectrum that is responsive to a chemical concentration; a spectrometer (120) configured to determine a spectral response of the optical cavity (110); a processor (130) configured to determine a first chemical concentration from the dye absorbance and/or fluorescence spectrum by spectroscopy, and to determine a wavelength of one or more Fabry-Pérot interference fringes from the optical cavity (110). Also disclosed is a method of chemical sensing using a fibre optic sensor. Also disclosed is a method of fabricating a chemical sensor, comprising: coating, by sol-gel deposition, a distal end (117) of an optical fibre (110) with a silica matrix comprising dye; drying the silica matrix comprising dye in a dry inert gas. Aspects of the invention may be used in a healthcare context.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
The present disclosure relates to a broadband filter for confining or attenuating electromagnetic interference noise from one or more electrical signal sources, In an embodiment, the broadband filter comprises one or more filter stages electrically coupled by galvanic or by electromagnetic means to the one or more electrical signal sources for confining or attenuating conducted electromagnetic interference noise; one or more conductive shields electrically coupled by galvanic or by electromagnetic means to the electrical signal sources wherein the shields encapsulate the filter stages for confining or attenuating conducted and/or radiated electromagnetic interference noise; and one or more conductive partition layers to encapsulate the one or more filter stages such that the partition layers electromagnetically couple adjacent filter stages for a selected frequency range of the electromagnetic interference noise. The thickness of the conductive partition layers is chosen to control the degree of coupling.
H03H 1/00 - Constructional details of impedance networks whose electrical mode of operation is not specified or applicable to more than one type of network
The invention relates to a method of transfecting a cell with a molecule, the method comprising the steps of: adding a molecule for transfection to the cells; and modulating the activity of protein kinase C (PKC) in the cell and/or providing a pH responsive peptide comprising between about 5 and about 20 histidine residues; and related compositions and uses in therapy.
This invention relates to novel Penicillium strains, the production of novel Penicillium strains, and the use of novel Penicillium strains in various end applications.
A spore-forming cell comprising a first nucleotide sequence encoding a riboswitch and a transcriptional activator, wherein the riboswitch modulates translation of the transcriptional activator in response to a First inducer, and a second nucleotide sequence encoding a target gene that regulates spore formation, wherein the target gene is expressed in response to a second inducer and translation of the transcriptional activator. Also provided is a method of culturing a spore-forming cell and a method of creating a spore, as well as uses of spore-forming cells and spores.
A method of measuring an acceleration using one or more trapped BECs and at least two atomic field modes within those BECs is described. A density distribution of at least one of the one or more BECs is modified by the acceleration, which leads to a change of the field modes' time evolution. The method comprises: selecting two modes that are differently affected by the acceleration; and measuring the acceleration-induced difference; and using the measured acceleration-induced difference to infer the acceleration. Also described is a method of measuring a field gradient using one or more trapped BECs. Each of the trapped BECs has a density distribution, and at least two atomic modes within those BECs, wherein the density distributions of the one or more BECs are modified by the field, which leads to a change of the atomic modes' time evolution. The method comprises selecting two atomic modes that are differently affected by the field; and measuring a field-induced difference between the selected atomic modes; and using the measured field-induced difference to infer a gradient of the field.
G01V 7/02 - Measuring gravitational fields or wavesGravimetric prospecting or detecting Details
G01P 15/08 - Measuring accelerationMeasuring decelerationMeasuring shock, i.e. sudden change of acceleration by making use of inertia forces with conversion into electric or magnetic values
G01V 7/00 - Measuring gravitational fields or wavesGravimetric prospecting or detecting
A method of reducing error in magnetoencephalography arising from the presence of a non-neuromagnetic field. The method comprises measuring, using a sensor array for measuring neuromagnetic fields, magnetic field at a plurality of discrete locations around a subject's head to provide sensor data, wherein the magnetic field measured at at least some of the locations includes a neuromagnetic field from a source of interest within a subject's brain and a non-neuromagnetic field from a source of no interest external to the brain. The measuring comprises: measuring, at at least a first subset of the locations, a magnetic field along a first direction relative to a radial axis intersecting the respective location, and measuring, at at least a second subset of the locations, a magnetic field along a second direction relative to a radial axis intersecting the respective location which is different to the first direction; and performing source reconstruction using the sensor data.
A61B 5/242 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
A61B 5/243 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetocardiographic [MCG] signals
A method of reducing error in magnetoencephalography arising from the presence of a non-neuromagnetic field. The method comprises measuring, using a sensor array for measuring neuromagnetic fields, magnetic field at a plurality of discrete locations around a subject's head to provide sensor data, wherein the magnetic field measured at at least some of the locations includes a neuromagnetic field from a source of interest within a subject's brain and a non-neuromagnetic field from a source of no interest external to the brain. The measuring comprises: measuring, at at least a first subset of the locations, a magnetic field along a first direction relative to a radial axis intersecting the respective location, and measuring, at at least a second subset of the locations, a magnetic field along a second direction relative to a radial axis intersecting the respective location which is different to the first direction; and performing source reconstruction using the sensor data.
A61B 5/242 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
A61B 5/243 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetocardiographic [MCG] signals
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
G01R 33/035 - Measuring direction or magnitude of magnetic fields or magnetic flux using superconductive devices
Described herein are "Ultrahapticons," which are a set of tangible and recognizable mid-air haptic icons that have been derived from research study participants' metaphorical associations with car infotainment features. In line with semiotic theory (the study of signs), data from the study was analyzed to identify key characteristics that when realized in mid-air haptic form, would enable a user to "feel" the feature they are interacting with. Their use is not limited to an automotive context, they can be instrumented to any application that exhibits the same feature functionality i.e. home entertainment system, laptop UI's, digital communication, Extended Reality (XR), and the like.
Described herein are “Ultrahapticons,” which are a set of tangible and recognizable mid-air haptic icons that have been derived from research study participants' metaphorical associations with car infotainment features. In line with semiotic theory (the study of signs), data from the study was analyzed to identify key characteristics that when realized in mid-air haptic form, would enable a user to “feel” the feature they are interacting with. Their use is not limited to an automotive context, they can be instrumented to any application that exhibits the same feature functionality i.e. home entertainment system, laptop UI's, digital communication, Extended Reality (XR), and the like.
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
B06B 1/16 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of mechanical energy operating with systems involving rotary unbalanced masses
Apparatus and methods for acquiring a Raman spectral map of a sample including a material species. The apparatus includes: a pulsed illumination source providing pulsed illumination radiation for exciting the sample and producing scattered radiation; a microscope objective focusing the pulsed illumination radiation onto a region of the sample corresponding to a data point of the map, and collecting emitted radiation from the region; a translation stage translating the sample relative to the microscope objective in at least two directions; a spectral filter spectrally filtering the emitted radiation collected by the objective to obtain a filtered portion of radiation corresponding to a characteristic Raman spectral feature of the material species; a detector receiving the filtered portion and providing output electrical pulses indicative thereof; and readout electronics applying a time gate to the output electrical pulses to distinguish detection events corresponding to the Raman scattered radiation from events associated with photoluminescence.
The invention relates to novel compounds of formula (I), the compounds being capable of acting as avß6 integrin antagonists, their use in the treatment of disease, their methods of manufacture and compositions comprising said compounds for such purposes (I) wherein R1 is selected from: R1a, -C(O)R1a, -C(O)OR1a -C(O)NHR1a, -C(O)N(R1a)2, -SO2R1a, wherein R1a are each independently selected from: alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl, each of which may be optionally substituted; R2 is selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R2a are each independently selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R3 is selected from: hydrogen, optionally substituted alkyl or optionally substituted alkoxyl; R4 is hydroxyl; Ar1 is an optionally substituted heteroaryl or bicyclic heteroaryl; and L is a linker; or a pharmaceutically acceptable salt thereof.
A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 11/00 - Drugs for disorders of the respiratory system
A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue
A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
v6 6 integrin antagonists, their use in the treatment of disease, their methods of manufacture and compositions comprising said compounds for such purposes (I) wherein R1is selected from: R1a, -C(O)R1a, -C(O)OR1a-C(O)NHR1a, -C(O)N(R1a222R1a, wherein R1aare each independently selected from: alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl, each of which may be optionally substituted; R2is selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R2aare each independently selected from: hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxyl; R3is selected from: hydrogen, optionally substituted alkyl or optionally substituted alkoxyl; R4is hydroxyl; Ar1 is an optionally substituted heteroaryl or bicyclic heteroaryl; and L is a linker; or a pharmaceutically acceptable salt thereof.
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 11/00 - Drugs for disorders of the respiratory system
A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 31/397 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
A method of designing at least one coil for producing a magnetic field is disclosed. The method comprises: i) setting a performance target comprising: a target magnetic field, and at least two of a target power, a target resistance, a target size and/or weight, a target supply voltage or current, and a target inductance; ii) determining initial design parameters for the at least one coil; iii) modelling performance with the current design parameters to determine a simulated performance against each of the performance targets; iv) calculating a penalty function based on the difference between the simulated performance and the performance targets; v) modifying the design parameters in order to reduce the penalty function; vi) iterating steps iii) to v) until the penalty function or simulated performance has met an acceptance condition.
A process (1, 2) for processing feedstock containing cotton fibres and PET fibres, the process (1, 2) comprises: i. heating a suspension of feedstock containing cotton fibres and PET fibres in water at a temperature above 180 °C to produce a mixture comprising char; ii. removing the water from the mixture comprising char; iii. adding a base to the mixture comprising char to produce a terephthalate salt in a liquid phase; iv. removing the char from the liquid phase to produce dried char; v. acidifying the liquid phase to produce terephthalic acid.
NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST (United Kingdom)
THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
Fateen, Waleed Amr Abdelkader
Armour, John Anthony
Aithal, Guruprasad Padur
Abstract
A method of diagnosing cancer or screening for cancer or a pre-cancerous condition in a subject. The method comprises the steps of calculating the ratio value between the copy number at a first genomic locus that characteristically exhibits a copy number gain in cancer and a second genomic locus that characteristically exhibits a copy number loss in cancer in a DNA sample obtained from the subject; and determining whether the ratio value exceeds a predetermined threshold value.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
60.
APPARATUS AND METHOD FOR MEASUREMENT OF BOWEL WALL INFLAMMATION OR PERMEABILITY
NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST (United Kingdom)
THE UNIVERSITY OF NOTTINGHAM (United Kingdom)
Inventor
Williams, Hannah
Scott, Robert
Gowland, Penelope Anne
Aithal, Guruprasad Padur
Abstract
A method of measuring the inflammation or permeability of the bowel wall is provided. The method comprises obtaining nuclear magnetic resonance measurements, in the form of an image, of at least a bowel including the bowel wall. A portion of the bowel wall is isolated within the image. From the image, a nuclear magnetic resonance measurement is determined for the isolated bowel wall. A measurement of the inflammation or permeability of the isolated bowel wall is then calculated based on its nuclear magnetic resonance measurement.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
The present invention relates to a system (100) for monitoring one or more physiological parameters of an individual. The system (100) comprises an optical fibre assembly (110) configured to measure one or more physiological parameters of an individual, and a pressure sensor (120) configured to measure a contact pressure of the optical fibre assembly (110) on the individual. The pressure sensor (120) comprises an optical fibre (122) comprising a transducer fibre Bragg grating (127) embedded in a matrix (121). The matrix (121) is configured to cause longitudinal strain in the transducer fibre Bragg grating (127) in response to the matrix (121) being subject to a transverse load. The one or more physiological parameters that the system (100) is for monitoring may include blood oxygen saturation (Sp O2), capillary refill time (CRT), heart rate, blood flow and CO2 emissions from skin.
D04B 1/16 - Other fabrics or articles characterised primarily by the use of particular thread materials synthetic threads
D03D 15/547 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads with optical functions other than colour, e.g. comprising light-emitting fibres
D05C 17/00 - Embroidered or tufted productsBase fabrics specially adapted for embroidered workInserts for producing surface irregularities in embroidered products
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
62.
MATERIALS CHEMISTRIES AND MICROTOPOGRAPHIES AND USES THEREOF
A microtopography system for modulating one or more cellular processes on a surface is described. In particular a microtopography system comprising: a repeated microtopographic pattern and a polymer coating, said microtopographic pattern comprising: an array of repeated micropillars applied to a surface of a product, said micropillars being formed of surface structures between 1-100 μm in height, and 1-50 μm in width; and said polymer coating comprising one of a (meth)acrylate or (meth)acrylamide monomer, or mixture of two (meth)acrylate or (meth)acrylamide monomers.The microtopographic pattern and said polymer coating act to modulate one or more cellular processes on the surface.
A microtopography system for modulating one or more cellular processes on a surface is described. The microtopography system comprising: a repeated microtopographic pattern, said microtopographic pattern comprising: an array of repeated micropillars applied to a surface of a product, said micropillars being formed of surface structures between 1-100 μm in height, and 1-50 μm in width. The microtopographic pattern acts to modulate one or more cellular processes on the surface.
The invention relates to methods of producing solid drug formulations using advanced manufacturing techniques, such as 3D printing, where there is a requirement for low viscosity. The invention uses a photo-reactive material in liquid form, the photo-reactive material comprising: (a) prodrug monomer that comprises an active pharmaceutical ingredient in a prodrug form, in which the active pharmaceutical ingredient is releasably attached to a polymerisable group via a releasable covalent bond, and, optionally, (b) diluent monomer that comprises a polymerisable group.
A method of manufacturing a storage device for storing information, apparatus for storing information, an optical memristor device and a memory cell are disclosed. A method comprises providing at least one first electrode and at least one further electrode and providing each of at least one region of a first material between, and in electrical connection with, a respective first electrode and a further electrode whereby said step of providing at least one region comprises providing in the first material, a plurality of changeable particles that have charge storage capacity and at least one electrical property that is reversibly changeable responsive to absorption of incident electromagnetic radiation.
The invention provides an isolated dehydrated corneal tissue, comprising a full thickness corneal stroma, and substantially all, or all, of the Bowman's membrane, wherein the stroma contains cellular material. Also provided is a method to product the tissue and uses of the tissue.
The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I)
The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I)
The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I)
wherein R1-R11, X, Y and Q are as defined herein. Also provided are pharmaceutical compositions and combinations comprising such agents. An in vitro method of evaluating the antiviral activity or potential antiviral activity of a compound against a virus is also provided.
The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) or (la) wherein R1-R4, A and B are as defined herein. Also provided are pharmaceutical compositions and combinations comprising such agents.
A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
C07C 67/28 - Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
C07C 69/21 - Acetic acid esters of hydroxy compounds with more than three hydroxy groups
C07C 69/33 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
C07C 69/533 - Monocarboxylic acid esters having only one carbon-to-carbon double bond
C07D 307/93 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A61K 31/7012 - Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
A method of designing a magnetic shield comprising a structure enclosing a space, the structure comprising passive magnetic shielding material and a winding configured to produce a specified magnetic within the structure when current is passed through the winding, is disclosed. The method comprises determining an optimised configuration of the winding accounting for the presence of the passive magnetic shield material by implementing one or more boundary conditions at the surface of the passive magnetic shielding material.
A method of coating an object, the method comprising: preparing a suspension comprising graphene nanoplatelets and a ceramic material; and spraying the suspension onto the object using high velocity oxy-fuel, HVOF, spraying in which the suspension is introduced as a feedstock.
An apparatus for carrying out chemical reactions is provided. The apparatus comprises a first reactor/reaction zone for carrying out a first chemical reaction and a second reactor/reaction zone for carrying out a second chemical reaction. Each reactor/reaction zone comprises: a) an inner surface and an outer surface which are spaced apart from each other to define a reaction volume configured such that, in use, a respective chemical reaction takes place in the reaction volume, and wherein the inner surface and outer surface are configured for relative rotation with respect to each other, (b) an inlet for introduction of a reagent to the reaction volume, and (b) an outlet through which a reaction product can leave the reaction volume. The reaction products of the first reactor/reaction zone comprise reagents of the second reactor/reaction zone.
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
B01J 19/18 - Stationary reactors having moving elements inside
72.
Method for producing metallurgical coke from non-coking coal
The present disclosure relates to a method for producing metallurgical coke from non-coking coal. The method comprising, densifying, the non-coking coal to form pellets. The densified pellets will be placed in a microwave oven within plurality of bricks and are subjected for pyrolysis. For carrying our pyrolysis, the pellets are carried out by heating, the pellets in the microwave oven at a predetermined temperature under an inert atmosphere at atmospheric pressure, and then the pellets are cooled in the microwave oven under the inert atmosphere. This process coverts non-coking coal to the metallurgical coke in a quicker time, and without use of any susceptors.
C10B 53/08 - Destructive distillation, specially adapted for particular solid raw materials or solid raw materials in special form in the form of briquettes, lumps or the like
C10B 19/00 - Heating of coke ovens by electrical means
Photogrammetric analysis of an object 10 is carried out by capturing images of the object 10. Photogrammetric analysis requires the capture of multiple overlapping images of the object 10 from various camera positions exemplified by positions 1-5. These images are then processed to generate a three-dimensional (3D) point cloud representing the object in 3D space. A 3D model of the object is used to generate a model 3D point cloud. Based on the modelled point cloud and camera optics, the visibility of each point in the 3D point cloud is determined for a range of possible camera positions. The radial component of the camera is fixed by defining a shell 20 of suitable camera positions around the part and for each position on the defined shell, the quality as a function of camera position is calculated. This defines a density function over the potential camera positions. Initial camera positions are selected based on the density function subject to refinement based on the overall expected quality of the photogrammetric analysis. The process can be repeated for different numbers of camera positions so that the optimum balance of time and accuracy is achieved.
The present invention relates to an electrical nerve stimulator configured to deliver an electrical signal to a user to entrain Mu-band neural oscillations and/or Beta-band neural oscillations. The electrical nerve stimulator may be used in the treatment of neurological conditions associated with desynchronization of neural oscillations, such as Tourette's syndrome. The electrical nerve stimulator may be wearable on a wrist of a user, and may be configured to deliver rhythmic stimulation at a frequency falling within the same frequency range of Mu-band or Beta-band neural oscillations. The invention provides a convenient means of treating conditions such as Tourette's syndrome without the need for specialist medical equipment or facilities. Also disclosed is a method of delivering an electrical signal to a user to entrain Mu-band neural oscillations and/or Beta-band neural oscillations.
A computing system comprising a generative neural network (100) is disclosed. The generative neural network (100) is configured to receive a plurality of input videos. Each input video comprises a face defining an identity. Each input video comprises a behaviour. Each input video comprises the same behaviour as each of the other input videos, and a different identity to each of the other input videos. The generative neural network (100) is also configured synthesize an output video from the input videos. The output video comprises a synthetic face defining a synthetic identity. The generative neural network has been trained, with a loss function, to preserve the behaviour of the input videos while generating the synthetic identity that is different from each identity of the input videos.
A method of measuring land deformation over time using interferograms derived from synthetic aperture radar data. The method includes: acquiring radar images covering an area at different points in time; deriving interferograms from pairs of the images, each interferogram measuring phase difference between pixels of a respective pair of images; for each pixel of the interferograms: determining an average coherence value over all of the interferograms; and if the average value is less than a threshold, determining an adjusted average coherence value equal to or above the threshold by excluding one or more of the interferograms below the threshold, provided the number of remaining interferograms is not less than a preset minimum number for each pixel of each interferogram for which the average or adjusted average coherence value is above the threshold, deriving vertical movement from the phase difference; and deriving the map of land deformation from the vertical movement.
A method of measuring an acceleration using one or more trapped BECs and at least two atomic field modes within those BECs is described. A density distribution of at least one of the one or more BECs is modified by the acceleration, which leads to a change of the field modes' time evolution. The method comprises: selecting two modes that are differently affected by the acceleration; and measuring the acceleration-induced difference; and using the measured acceleration-induced difference to infer the acceleration. Also described is a method of measuring a field gradient using one or more trapped BECs. Each of the trapped BECs has a density distribution, and at least two atomic modes within those BECs, wherein the density distributions of the one or more BECs are modified by the field, which leads to a change of the atomic modes' time evolution. The method comprises selecting two atomic modes that are differently affected by the field; and measuring a field- induced difference between the selected atomic modes; and using the measured field- induced difference to infer a gradient of the field.
G01V 7/02 - Measuring gravitational fields or wavesGravimetric prospecting or detecting Details
G01P 15/08 - Measuring accelerationMeasuring decelerationMeasuring shock, i.e. sudden change of acceleration by making use of inertia forces with conversion into electric or magnetic values
An electrochemical machining device is provided for machining a surface of a workpiece. The electrochemical machining device includes a base unit and a portable machining unit. The machining unit includes a housing, a nozzle disposed within the housing and configured for dispensing an electrolyte jet towards a surface of a workpiece. The machining unit is connected to the base unit via an umbilical cord for supplying power to the machining unit and for supplying electrolyte to the nozzle. The electrochemical machining device is applies a charge to the nozzle and a surface of a workpiece such that the nozzle and said surface define first and second electrodes of an electrolytic cell, in use. The nozzle is arranged so as to be spaced apart from a surface of a workpiece, in use.
The invention relates to a method of diagnosis of tuberculosis (TB)disease in asubject. The method comprises admixing a Mycobacteria-specific bacteriophage with asample of peripheral blood mononuclear cells(PBMCs) from the subject, followed by determination of the presence or absence of a Mycobacterial DNA sequence in DNA isolated from the admixture. The invention provides a sensitive and specific test for the presence of incipient TB, i.e. an asymptomatic infectionwith a high risk of developing active TB, or for the presence oflatent tuberculosis infection(LTBI), i.e. an asymptomatic infection that is not likely to develop into active TB, in a subject.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
The present disclosure relates to a broadband filter for confining or attenuating electromagnetic interference noise from one or more electrical signal sources, In an embodiment, the broadband filter comprises one or more filter stages electrically coupled by galvanic or by electromagnetic means to the one or more electrical signal sources for confining or attenuating conducted electromagnetic interference noise; one or more conductive shields electrically coupled by galvanic or by electromagnetic means to the electrical signal sources wherein the shields encapsulate the filter stages for confining or attenuating conducted and/or radiated electromagnetic interference noise; and one or more conductive partition layers to encapsulate the one or more filter stages such that the partition layers electromagnetically couple adjacent filter stages for a selected frequency range of the electromagnetic interference noise. The thickness of the conductive partition layers is chosen to control the degree of coupling.
H03H 1/00 - Constructional details of impedance networks whose electrical mode of operation is not specified or applicable to more than one type of network
The invention relates to a method of transfecting a cell with a molecule, the method comprising the steps of: adding a molecule for transfection to the cells; and modulating the activity of protein kinase C (PKC) in the cell and/or providing a pH responsive peptide comprising between about 5 and about 20 histidine residues; and related compositions and uses in therapy.
The invention relates to a method of transfecting a cell with a molecule, the method comprising the steps of: adding a molecule for transfection to the cells; and modulating the activity of protein kinase C (PKC) in the cell and/or providing a pH responsive peptide comprising between about 5 and about 20 histidine residues; and related compositions and uses in therapy.
A hat (200) for a neonate (120) comprising: a central portion (201), a first side portion (202) and second side portion (203) attached to opposite sides of the central portion (201), a first fastener (208); a top flap (204) and a second fastener (211). The hat (200) has an unfolded configuration and a worn configuration. In the unfolded configuration the first and second portions (202, 203) extend away from each other from the central portion (201) in opposite directions. In the worn configuration the hat (200) wraps a neonate's head with the central portion (201) in contact with the back of the neonate's head, the first portion (202) wrapped around a first side of the neonate's head and the second portion (203) wrapped around a second side of the neonate's head. The first and second portions (202, 203) are configured to be fastened together in the worn configuration by the first fastener (208) so that the first portion (202), central portion (201) and second portion (203) together define a hat (214) rim encircling the neonate's head. The top flap (204) is configured to cover the top of the neonate's head in the worn configuration. The top flap (204) is configured to be fastened to at least one of the first, central and second portions (202, 201, 203) by the second fastener (211). The hat (200) further comprises an optical physiological sensor that comprises: a flexible circuit board, a light emitter (310) and a light detector (311); the flexible circuit board having: a sensor portion (302) to which the light emitter (310) and light detector (311) are connected; a module portion (305) including contacts (304) for electrically connecting the light emitter (310) and light detector (311) to a removable readout module (400); and an elongate lead portion (301) between the sensor portion (302) and module portion (305).
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
86.
Heterocyclyl substituted pyrrolopyridines that are inhibitors of the CDK12 kinase
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
A61P 35/04 - Antineoplastic agents specific for metastasis
A spore-forming cell comprising a first nucleotide sequence encoding a riboswitch and a transcriptional activator, wherein the riboswitch modulates translation of the transcriptional activator in response to a First inducer, and a second nucleotide sequence encoding a target gene that regulates spore formation, wherein the target gene is expressed in response to a second inducer and translation of the transcriptional activator. Also provided is a method of culturing a spore-forming cell and a method of creating a spore, as well as uses of spore-forming cells and spores.
A genetic construct comprising a DNA polynucleotide sequence which encodes a riboswitch operably linked to a coding region, wherein the coding region encodes a target gene and the riboswitch modulates translation or transcription of the coding region. A vector or a host cell comprising the genetic construct of the invention. A method of controlling expression of a target gene in a cell using the genetic construct of the invention.
C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
A composition of polymer particles, wherein the polymer particles are loaded with an agent that is capable of enhancing the binding of islet cells to liver tissue, and wherein (i) the polymer particles comprise linked molecules, wherein the linked molecules comprise:a) asialoglycoprotein receptor (ASGPR)-binding molecules that are capable of binding the asialoglycoprotein receptor (ASGPR) on a cell surface, orb) a binding- molecule that is specific for a cell surface marker that is predominantly present in liver tissue; and/or (ii) the polymer particles are between about 0.5 and about 100 microns in diameter.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
91.
USE OF 4-(BENZOTHIAZOLE-2-YL)ARYLAMINE COMPOUND IN TREATING STOMACH CANCER
KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (China)
Inventor
Bradshaw, Tracey, D.
Stevens, Malcolm, F., G.
Zhang, Jihong
Wang, Yuling
Shi, Dongfang
Cheng, Xi
Abstract
Disclosed is the use of a 4-(benzothiazole-2-yl)arylamine compound in treating stomach cancer, wherein the compound is a compound as shown in general formula I or a pharmaceutically acceptable salt thereof.
A method of designing at least one coil for producing a magnetic field is disclosed. The method comprises: i) setting a performance target comprising: a target magnetic field, and at least two of a target power, a target resistance, a target size and/or weight, a target supply voltage or current, and a target inductance; ii) determining initial design parameters for the at least one coil; iii) modelling performance with the current design parameters to determine a simulated performance against each of the performance targets; iv) calculating a penalty function based on the difference between the simulated performance and the performance targets; v) modifying the design parameters in order to reduce the penalty function; vi) iterating steps iii) to v) until the penalty function or simulated performance has met an acceptance condition.
A surface topography sensing apparatus (10) comprises a light source (11) operable to generate a reference light beam (12) which is incident upon a surface (1). The scattered reference light (13) is captured by a light detector (14), thereby capturing a characteristic angular scattering distribution (ASD) for the point where the beam (12) scatters from surface (1). The ASD is generated by a processing module (16) connected to the light detector (14). Once the ASD is generated, the processing module 16 is operable to compare the generated ASD against a library (17) of sample ASDs, each sample ASD representative of a particular expected surface topography condition for the specific application being studied. Based on the comparison, the processing module may then assign a classification of the topography of surface (1).
The disclosure relates to Raman spectroscopy, in particular to apparatus and methods for acquisitions of a Raman spectral map of a sample. Example embodiments disclosed include an apparatus (100) for acquiring a Raman spectral map (101) of a sample (108) comprising a material species, the Raman spectral map (101) consisting of an array of data points corresponding to respective regions of the sample (108), the apparatus (100) comprising: a pulsed illumination source (102) arranged to provide pulsed illumination radiation (104) for exciting the sample (108) and producing scattered radiation; a microscope objective (106) arranged to focus the pulsed illumination radiation (104) onto a region of the sample (108) corresponding to a data point of the Raman spectral map (101), and further arranged to collect emitted radiation (114) from said region; a translation stage (112) arranged to translate the sample (108) relative to the microscope objective (106) in at least two directions; a spectral filter (130) arranged to spectrally filter the emitted radiation collected by the microscope objective (106) to obtain a filtered portion (132) of the emitted radiation (114) corresponding to one or more characteristic Raman spectral features of the material species; a detector (134) arranged to receive said filtered portion (132) of the emitted radiation (114) and to provide output electrical pulses indicative thereof; and readout electronics (146) connected to the detector (134) and operable to apply a time gate to said output electrical pulses to distinguish detection events corresponding to Raman scattered radiation associated with the material species from detection events associated with photoluminescence.
The present invention relates to a system (100) for monitoring one or more physiological parameters of an individual. The system (100) comprises an optical fibre assembly (110) configured to measure one or more physiological parameters of an individual, and a pressure sensor (120) configured to measure a contact pressure of the optical fibre assembly (110) on the individual. The pressure sensor (120) comprises an optical fibre (122) comprising a transducer fibre Bragg grating (127) embedded in a matrix (121). The matrix (121) is configured to cause longitudinal strain in the transducer fibre Bragg grating (127) in response to the matrix (121) being subject to a transverse load. The one or more physiological parameters that the system (100) is for monitoring may include blood oxygen saturation (Sp O2), capillary refill time (CRT), heart rate, blood flow and CO2 emissions from skin.
The invention may provide, in part, compounds for use as antiproliferative, chemotherapeutic, antiviral, cell sensitising or adjuvant agents, and pharmaceutical compositions including the compounds. The compounds may be for use in treating diseases and disorders related to cell proliferation such as cancer, or in treating diseases and disorder which are linked to aberrant control of protein synthesis, such as cancer, viral infection, muscle wasting, autistic spectrum disorders, Alzheimer's disease, Huntingdon's disease and Parkinson's disease.
C07H 15/06 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical being a hydroxyalkyl group esterified by a fatty acid
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 31/7032 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
The present invention relates to crop breeding. More particularly, the present invention relates to targeted modification of root to enhance abiotic stress tolerance in maize. In one aspect, the invention provides recombinant maize exhibiting increased root cortical aerenchyma (RCA). Methods of making the recombinant maize and various methods of plant selection and breeding are further provided.
The invention provides an agent for the treatment or prevention of viral infection in a subject. The agent is preferably a compound of Formula (I) wherein R1-R11in vitroin vitro method of evaluating the antiviral activity or potential antiviral activity of a compound against a virus is also provided.
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
A61K 31/7012 - Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A mixing reactor for precipitating nanoparticles by mixing a precursor fluid with a second fluid at a higher temperature than the precursor fluid. The reactor comprises: a first fluid conduit with an inlet region configured to receive a flow of the precursor fluid, and an outlet region configured to output a mixed flow; and a second fluid conduit configured to receive a flow of the second fluid. The second fluid conduit extends into the first fluid conduit in a direction substantially perpendicular to the flow within the first fluid conduit, and has an opening for introducing the second fluid into the first fluid conduit. Related processes for producing nanoparticles are disclosed.
B01J 3/00 - Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matterApparatus therefor
B01J 19/24 - Stationary reactors without moving elements inside
B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
a) have two or fewer reactive groups, and allowing (330) linear polymeric chains in said layer of polymeric material (100) to react with reactive units in said reactive liquid (200) so as to form extended polymeric chains that are linear, so as to provide a shaped layer of linear polymer. These steps (310, 320, 330) are repeated as required to form the object from successive shaped layers of linear polymer.
B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
