Abstract

Systems using acoustic metamaterial surfaces comprise arrangements of unit cells arranged to introduce time delays to an incident acoustic wave. In certain embodiments the relative positions of two or more acoustic metasurfaces are selected or adjusted to control the acoustic output of the system such that the acoustic output of the system is a non-linear combination of the respective operations performed by the plurality of acoustic metasurfaces, the non-linear combination being a convolution of the respective operations performed by the plurality of acoustic metasurfaces that is determined as a function of the relative positioning between the acoustic metasurfaces. Further disclosed are applications of such acoustic metasurfaces in noise-reducing structures.

IPC Classes  ?

• G10K 11/30 - Sound-focusing or directing, e.g. scanning using refraction, e.g. acoustic lenses
• G10K 11/175 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using interference effectsMasking sound

Abstract

The invention relates to a sensor for use in a system for determining a three-dimensional surface shape of a human or animal body, the sensor comprising: a base comprising at least two sensing elements, and a deformable substrate comprising a conductive target over the base so as to provide a sensing capacitance and/or inductance across and/or resistance along the elements, wherein the sensor is adapted to change the sensing capacitance, inductance and/or resistance in response to a strain selected from: compression, stretch and bend, applied to the sensor. Also described is the use of the sensor in a system and method for determining a three-dimensional surface shape of a human or animal body, and in a stretchable material.

IPC Classes  ?

• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
• G01B 7/24 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring the deformation in a solid, e.g. by resistance strain gauge using change in magnetic properties

Abstract

A contact force sensor is disclosed which indicates the location and magnitude of a contact force on the input surface of the sensor. The sensor may be used to provide an input to a computer processor and may be used in the fields of robotics, teleoperation, AR or VR. Contact force sensor (200) comprises input layer (210), emission layer (220), transmission layer 230 and masking layer (240). The input layer (210) and emission layer (220) are deformable when the contact force is applied. The emission layer (220) is configured to emit electromagnetic radiation (e.g. light). The transmission layer (230) is also deformable and transmits the electromagnetic radiation received from the emission layer (220) to a plurality of projections (231) which project through the masking layer (240). The projections are the output points on the output surface of the sensor. The deformation of the transmission layer caused by the application of a force to the input layer (210) causes a change in the intensity of electromagnetic radiation transmitted to at least one of the output points closest to the point of application of the contact force on the sensor. The location of the changed intensity and the relative change of the intensity provides the indication of the location and magnitude of the contact force received by the input surface of the sensor.

IPC Classes  ?

• G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis
• G01L 5/22 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for measuring the force applied to control members, e.g. control members of vehicles, triggers
• G01L 5/00 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes
• B25J 9/16 - Programme controls
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices

Abstract

The present invention is in the field of amyotrophic lateral sclerosis (ALS) and relates to human interleukin-2 (IL-2) for use in the treatment of amyotrophic lateral sclerosis in a human subject, wherein each dose of human IL-2 administered to said subject is between 0.1×106 to 3×106 international units (IU). Human IL-2 is preferably administered in cycles of 3 to 7 days of once-daily sub-cutaneous injection of 0.1×106 to 3×106 IU human IL-2. The treatment does not comprise the administration of regulatory T cells to the subject, who is preferably also under riluzole treatment. The administered human IL-2 is preferably not complexed with anti-hIL-2 antibodies and the treatment also preferably does not comprise the administration of rapamycin or any other suppressive agent of effector T cells (Teffs) to the subject. The treatment permits to decrease plasma CCL2 concentration and to change the polarization of blood macrophages from an M1 inflammatory phenotype to an anti-inflammatory M2 phenotype involved in tissue repair.

IPC Classes  ?

• A61K 38/20 - Interleukins
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention provides a mechanochemical process for synthesising a cyanine compound of Formula (I), such as indocyanine green. The process is carried out in the absence of solvent.

IPC Classes  ?

• C09B 23/08 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups more than three CH groups, e.g. polycarbocyanines
• C07D 209/60 - Naphtho [b] pyrrolesHydrogenated naphtho [b] pyrroles

Abstract

A quantum illumination apparatus includes an ion trap in a cryogenic cooler. The ion trap uses electric and magnetic fields to trap an ion and the quantum illumination apparatus uses the trapped ion to produce a signal photon for use in quantum illumination. The signal photon has correlations with an idler field stored with use of the trapped ion, as a phonon of the trapped ion. A signal photon transmission line extends between the ion trap and an antenna. The signal photon may be scattered, e.g., reflected or refracted, by a target object back to the antenna, and the transmission line transmits the signal photon back to the ion trap. The ion trap generates an electrical signal based on correlations between the signal photon and the idler field. The quantum illumination apparatus is arranged to detect reception of the signal photon based on this generated electrical signal.

IPC Classes  ?

• G21K 1/093 - Deviation, concentration, or focusing of the beam by electric or magnetic means by magnetic means

Abstract

The present invention is in the field of amyotrophic lateral sclerosis (ALS) and relates to human interleukin-2 (IL-2) for use in the treatment of amyotrophic lateral sclerosis in a human subject, wherein each dose of human IL-2 administered to said subject is between 0.1 x106to 3x106 international units (IU) and the subject has a low to medium concentration of p-NFH in cerebrospinal fluid (CSF p-NFH) or a low to medium concentration of NFL or NFM in cerebrospinal fluid, blood, serum or plasma before human IL-2 administration. The invention also relates to medical uses where the CSF p-NFH or CSF, blood, serum or plasma NFL or NFM concentration is used to select the best administration scheme or as a biomarker for stratified randomization of a cohort of ALS patients in the context of a clinical trial assessing the therapeutic efficiency of a candidate ALS treatment.

IPC Classes  ?

• A61K 38/20 - Interleukins
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

There is disclosed a method of generating terahertz radiation which comprises: (a) depositing an ink on a substrate (2), wherein the ink comprises particles (3) of a semiconductor; (b) allowing the ink to form a coating; (c) shining a laser onto the coating so as to generate terahertz radiation.

IPC Classes  ?

• C09D 11/52 - Electrically conductive inks
• C09D 11/38 - Inkjet printing inks characterised by non-macromolecular additives other than solvents, pigments or dyes
• G02F 1/35 - Non-linear optics
• G02F 1/355 - Non-linear optics characterised by the materials used

Abstract

A device for manipulating an incident acoustic wave to generate an acoustic output is described wherein the device comprises a plurality of unit cells arranged into an array, at least some of said unit cells being configured to introduce time delays to an incident acoustic wave at the respective positions of the unit cells within the array of unit cells, such that said plurality of unit cells define an array of time delays to thereby define a spatial delay distribution for manipulating an incident acoustic wave to generate an acoustic output. The array of time delays may be re-configured to vary the spatial delay distribution of the device in order to generate different acoustic outputs. Also described are methods for designing or configuring such devices.

IPC Classes  ?

• H04R 3/12 - Circuits for transducers for distributing signals to two or more loudspeakers
• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• G01N 29/26 - Arrangements for orientation or scanning
• G10K 11/26 - Sound-focusing or directing, e.g. scanning
• H04R 1/02 - CasingsCabinetsMountings therein
• H04R 1/34 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only by using a single transducer with sound reflecting, diffracting, directing or guiding means
• H04R 1/40 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only by combining a number of identical transducers

Abstract

The invention provides a Raman-detectible composition comprising two or more different Raman-active 2D materials. Also provided is a formulation comprising the Raman-detectible composition and a binder; a substrate comprising the Raman-detectible composition; the use of the Raman-detectible composition to tag a substrate; a method for tagging a substrate with the Raman-detectible composition; and a method for analysing a substrate or formulation for the presence of the Raman detectible composition.

IPC Classes  ?

• B42D 25/378 - Special inks
• G07D 7/1205 - Testing spectral properties
• B42D 25/29 - Securities Bank notes
• G01N 21/65 - Raman scattering
• C09D 11/037 - Printing inks characterised by features other than the chemical nature of the binder characterised by the pigment
• C09D 11/033 - Printing inks characterised by features other than the chemical nature of the binder characterised by the solvent
• C09D 11/106 - Printing inks based on artificial resins containing macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

A device for controlling noise comprising one or more acoustic metamaterial cells (101) arranged relative to a flow passage (107) such that when an acoustic wave is incident on the device, a first portion of the acoustic wave propagates through the flow passage and a second portion of the acoustic wave propagates through the one or more acoustic metamaterial cells, the acoustic metamaterial cells being structured such that the second portion of the acoustic wave is thereby delayed relative to the first portion of the wave, and the first and second portions of the acoustic wave destructively interfere to provide noise reduction at one or more frequencies based on the respective time delays associated with the one or more acoustic metamaterial cells.

IPC Classes  ?

• G10K 11/16 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
• G10K 11/172 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using resonance effects
• F24F 13/24 - Means for preventing or suppressing noise

Abstract

The present invention relates to compounds of formula (I) and compositions comprising the same. The compounds and compositions may be used treat, prevent or ameliorate diseases treatable by inhibition of the Lemur tyrosine kinase 3 (LMTK3), such as cancer.

IPC Classes  ?

• A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/433 - Thiadiazoles
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a capsule comprising a shell and a core, wherein the shell comprises a crosslinked polymer and at least one 1D or 2D material, and the core comprises the at least one 1 D or 2D material and a solvent. The intention also relates to a method of forming the capsules, the method comprising: (a) forming a mixture comprising one or more 1D or 2D materials, a solvent and a cross-linkable polymer; (b) extruding the mixture; and (c) contacting the extrudate with a cross-linking agent.

IPC Classes  ?

• B01J 13/14 - Polymerisation, crosslinking

Abstract

The present invention is in the field of amyotrophic lateral sclerosis (ALS) and relates to human interleukin-2 (IL-2) for use in the treatment of amyotrophic lateral sclerosis in a human subject, wherein each dose of human IL-2 administered to said subject is between 0.1×106 to 3×106 international units (IU) Human IL-2 is preferably administered in cycles of 3 to 7 days of once-daily sub-cutaneous injection of 0.1×106 to 3×106 HI human IL-2. The treatment does not comprise the administration of regulatory T cells to the subject, who is preferably also under riluzole treatment. The administered human IL-2 is preferably not complexed with anti-hIL-2 antibodies and the treatment also preferably does not comprise the administration of rapamycin or any other suppressive agent of effector T cells (Teffs) to the subject. The treatment permits to decrease plasma CCL2 concentration and to change the polarization of blood macrophages from an M1 inflammatory phenotype to an anti-inflammatory M2 phenotype involved in tissue repair.

IPC Classes  ?

• A61K 38/20 - Interleukins
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

A surface ion trap comprising a plurality of electrodes and DACs, each electrode being controlled by a DAC, wherein a first set of DACs control the electrodes configured to trap an ion in a first area and a second set of DACs control the electrodes configured to trap an ion in a second area wherein the first set of DACs are configured to operate with low noise and low bandwidth and the second set of DACs are configured to operate with a high bandwidth and high noise.

IPC Classes  ?

• H03M 1/66 - Digital/analogue converters
• H03M 1/00 - Analogue/digital conversionDigital/analogue conversion
• G06N 10/00 - Quantum computing, i.e. information processing based on quantum-mechanical phenomena
• G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating

Abstract

A method for non-invasive characterisation of a cell for a battery is provided, the method comprising: measuring a magnetic field generated by the cell using a plurality of magnetic field sensors positioned adjacent to the cell, the measuring producing magnetic field sensor data, wherein the measuring is performed while the cell is in a passive state; determining current density profile data across the cell based on the magnetic field sensor data; and determining a condition of the cell using the current density profile data.

IPC Classes  ?

• G01R 31/3828 - Arrangements for monitoring battery or accumulator variables, e.g. SoC using current integration
• G01R 31/396 - Acquisition or processing of data for testing or for monitoring individual cells or groups of cells within a battery
• G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux

Abstract

A quantum illumination apparatus (100) comprises an ion trap (104). The quantum illumination apparatus (100) has a cryogenic cooler (102) in which the ion trap (104) is provided. The ion trap (104) uses electric and magnetic fields to trap an ion and the quantum illumination apparatus (100) is arranged to use the trapped ion to produce a signal photon for use in quantum illumination. The signal photon has correlations with an idler field stored with use of the trapped ion, in the form of a phonon of the trapped ion. A signal photon transmission line (106) extends between the ion trap (104) and an antenna (108). The signal photon may be scattered, e.g. reflected or refracted, by a target object (110) back to the antenna (108), and the transmission line (106) is arranged to transmit the signal photon back to the ion trap (104). The ion trap (104) is arranged to allow the signal photon to interact with the trapped ion and hence the idler field. Specifically, the ion trap (104) is arranged to generate an electrical signal based on correlations between the signal photon and the idler field. The quantum illumination apparatus (100) is arranged to detect reception of the signal photon based on this generated electrical signal.

IPC Classes  ?

• G01S 13/04 - Systems determining presence of a target
• G01S 7/28 - Details of pulse systems
• G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section

Abstract

The invention provides an apparatus for use in determining the three-dimensional shape of an object, which apparatus comprises: an article, comprising a stretchable material, and a plurality of strain sensors positioned in contact with the material such that stretching of the material is detectable by the sensors; a computing device operatively coupled to the article and configured to receive output data from the sensors and to process the data to determine the three dimensional shape of the object. The invention also provides a method for providing a customized orthotic product using the apparatus.

IPC Classes  ?

• A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

Abstract

A device for manipulating an incident acoustic wave to generate an acoustic output is described wherein the device comprises a plurality of unit cells arranged into an array, at least some of said unit cells being configured to introduce time delays to an incident acoustic wave at the respective positions of the unit cells within the array of unit cells, such that said plurality of unit cells define an array of time delays to thereby define a spatial delay distribution for manipulating an incident acoustic wave to generate an acoustic output. The array of time delays may be re-configured to vary the spatial delay distribution of the device in order to generate different acoustic outputs. Also described are methods for designing or configuring such devices.

IPC Classes  ?

• G10K 11/26 - Sound-focusing or directing, e.g. scanning
• H04R 3/12 - Circuits for transducers for distributing signals to two or more loudspeakers
• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• G01N 29/26 - Arrangements for orientation or scanning
• H04R 1/02 - CasingsCabinetsMountings therein
• H04R 1/34 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only by using a single transducer with sound reflecting, diffracting, directing or guiding means
• H04R 1/40 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only by combining a number of identical transducers

Abstract

The present invention relates to a method of making a composite material, the method comprising: (1) forming a Pickering emulsion comprising a continuous liquid phase, a discontinuous liquid phase, and a 2D material: wherein the discontinuous liquid phase comprises a polysiloxane and a curing agent; (2) leaving the Pickering emulsion formed in step (1) in a sealed system for sufficient time to at least partially cure the polysiloxane: and (3) allowing any remaining liquid to evaporate.

IPC Classes  ?

• C08J 3/05 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media from solid polymers
• C08J 3/09 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in organic liquids
• C08K 3/04 - Carbon

Abstract

There is disclosed a method of generating terahertz radiation which comprises: (a) depositing an ink on a substrate (2), wherein the ink comprises particles (3) of a semiconductor; (b) allowing the ink to form a coating; (c) shining a laser onto the coating so as to generate terahertz radiation.

IPC Classes  ?

• G02F 1/35 - Non-linear optics
• G02F 1/355 - Non-linear optics characterised by the materials used

Goods & Services

Research, development and consultancy in the field of health, medicine, education and science; biological research; research relating to medicine; medical research services; advisory services relating to the development of computer systems for the purpose of medical education and training; Compilation of medical and scientific information; Computer programming in the medical field; Consultancy relating to the development of computer systems for the purpose of medical education and training; Design and development of computer software for use with medical educational technology; Design and development of medical educational technology; Development and design of mobile applications for the purpose of medical and educational training; Development of application software for delivery of multimedia content for the purpose of medical and educational training; Information technology services for the medical and educational sectors; Software as a service (SaaS) for the purpose of medical and educational training; Technical advice and consultancy services in the field of medical and educational training; advice and consultancy in relation to all of the aforesaid. Providing news and information in the field of medicine and medical training; Medical information services; medical consultancy services; Medical analysis services; Advisory services relating to medical wellbeing and health; Advisory services relating to medical treatment and procedures; Compilation of medical reports; Consultancy and information services relating to medical products, procedures, training and education; Consultancy relating to health care; Health advice and information services; Health care consultancy services (medical); Healthcare information services; Medical care and analysis services relating to patient treatment; Medical diagnostic services; Medical health assessment services; Medical information (Provision of -); Medical treatment services provided by clinics and hospitals; Providing health information; Providing medical information; Provision of information relating to medicine; Services for the provision of medical care information; Technical consultancy services relating to medical health; advisory and consultancy in relation to all of the aforesaid; advice and consultancy in relation to all of the aforesaid.

Abstract

Disclosed herein are systems using acoustic metamaterial surfaces comprising arrangements of unit cells arranged to introduce time delays to an incident acoustic wave. In embodiments the relative positions of two or more acoustic metasurfaces (81, 82) is selected or adjusted to control the acoustic output of the system such that the acoustic output of the system is a non-linear combination of the respective operations performed by the plurality of acoustic metasurfaces (81, 82), the non-linear combination being a convolution of the respective operations performed by the plurality of acoustic metasurfaces that is determined as a function of the relative positioning between the acoustic metasurfaces (81, 82). Also disclosed are applications of such acoustic metasurfaces in noise-reducing structures.

IPC Classes  ?

• G10K 11/175 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using interference effectsMasking sound
• G10K 11/16 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
• G10K 11/30 - Sound-focusing or directing, e.g. scanning using refraction, e.g. acoustic lenses

Abstract

The invention provides a Raman-detectible composition comprising two or more different Raman-active 2D materials. Also provided is a formulation comprising the Raman-detectible composition and a binder; a substrate comprising the Raman- detectible composition; the use of the Raman-detectible composition to tag a substrate; a method for tagging a substrate with the Raman-detectible composition; and a method for analysing a substrate or formulation for the presence of the Raman detectible composition.

IPC Classes  ?

• G07D 7/0043 - Testing specially adapted to determine the identity or genuineness of valuable papers or for segregating those which are unacceptable, e.g. banknotes that are alien to a currency using digital security elements, e.g. information coded on a magnetic thread or strip using barcodes
• G07D 7/1205 - Testing spectral properties
• G07D 7/202 - Testing patterns thereon using pattern matching
• G01N 21/65 - Raman scattering
• B42D 25/29 - Securities Bank notes
• B42D 25/36 - Identification or security features, e.g. for preventing forgery comprising special materials
• B42D 25/415 - Marking using chemicals
• C09D 11/00 - Inks

Abstract

The present invention relates to compounds of formula (I) and compositions comprising the same. The compounds and compositions may be used treat, prevent or ameliorate diseases treatable by inhibition of the Lemur tyrosine kinase 3 (LMTK3), such as cancer.

IPC Classes  ?

• A61K 31/433 - Thiadiazoles
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61P 35/00 - Antineoplastic agents

Abstract

The disclosure provides a method of producing a pharmaceutical composition. The method comprises (a) dissolving an active pharmaceutical ingredient (API) in a liquid vehicle to form a liquid medicament; (b) contacting the liquid medicament with a pharmaceutical carrier; (c) contacting the composition comprising the liquid medicament and pharmaceutical carrier with a pharmaceutical coating material to form a liqui-mass composition; and (d) pelletising the liqui-mass composition to form the pharmaceutical composition.

IPC Classes  ?

• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present invention is in the field of amyotrophic lateral sclerosis (ALS) and relates to human interleukin-2 (IL-2) for use in the treatment of amyotrophic lateral sclerosis in a human subject, wherein each dose of human IL-2 administered to said subject is between 0.1 x106 to 3x106 international units (IU). Human IL-2 is preferably administered in cycles of 3 to 7 days of once-daily sub-cutaneous injection of 0.1 x106 to 3x106 IU human IL-2. The treatment does not comprise the administration of regulatory T cells to the subject, who is preferably also under riluzole treatment. The administered human IL-2 is preferably not complexed with anti-hIL-2 antibodies and the treatment also preferably does not comprise the administration of rapamycin or any other suppressive agent of effector T cells (Teffs) to the subject. The treatment permits to decrease plasma CCL2 concentration and to change the polarization of blood macrophages from an M1 inflammatory phenotype to an anti-inflammatory M2 phenotype involved in tissue repair.

IPC Classes  ?

• A61K 38/20 - Interleukins
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention is in the field of amyotrophic lateral sclerosis (ALS) and relates to human interleukin-2 (IL-2) for use in the treatment of amyotrophic lateral sclerosis in a human subject, wherein each dose of human IL-2 administered to said subject is between 0.1 x106to 3x106international units (IU). Human IL-2 is preferably administered in cycles of 3 to 7 days of once-daily sub-cutaneous injection of 0.1 x106to 3x106 IU human IL-2. The treatment does not comprise the administration of regulatory T cells to the subject, who is preferably also under riluzole treatment. The administered human IL-2 is preferably not complexed with anti-hIL-2 antibodies and the treatment also preferably does not comprise the administration of rapamycin or any other suppressive agent of effector T cells (Teffs) to the subject. The treatment permits to decrease plasma CCL2 concentration and to change the polarization of blood macrophages from an M1 inflammatory phenotype to an anti-inflammatory M2 phenotype involved in tissue repair.

IPC Classes  ?

• A61K 38/20 - Interleukins
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

A device for manipulating an incident acoustic wave to generate an acoustic output is described wherein the device comprises a plurality of unit cells arranged into an array, at least some of said unit cells being configured to introduce time delays to an incident acoustic wave at the respective positions of the unit cells within the array of unit cells, such that said plurality of unit cells define an array of time delays to thereby define a spatial delay distribution for manipulating an incident acoustic wave to generate an acoustic output. The array of time delays may be re-configured to vary the spatial delay distribution of the device in order to generate different acoustic outputs. Also described are methods for designing or configuring such devices.

IPC Classes  ?

• H04R 3/12 - Circuits for transducers for distributing signals to two or more loudspeakers
• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• G01N 29/26 - Arrangements for orientation or scanning
• G10K 11/26 - Sound-focusing or directing, e.g. scanning
• H04R 1/02 - CasingsCabinetsMountings therein
• H04R 1/34 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only by using a single transducer with sound reflecting, diffracting, directing or guiding means
• H04R 1/40 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only by combining a number of identical transducers

Abstract

The present invention relates to a hypoxia-inducible factor (HIF) activator, or a pharmaceutically acceptable salt or solvate thereof, for use in promoting tissue repair. The HIF activator, or the pharmaceutically acceptable salt or solvate thereof, is for use with a prototypical tissue-protective cytokine, or a pharmaceutically acceptable salt or solvate thereof, which is administered exogenously to the body being treated.

IPC Classes  ?

• A61K 38/18 - Growth factorsGrowth regulators
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/70 - Web, sheet or filament bases
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/225 - Polycarboxylic acids
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/4704 - 2-Quinolinones, e.g. carbostyril
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 33/24 - Heavy metalsCompounds thereof
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A61K 31/472 - Non-condensed isoquinolines, e.g. papaverine

Abstract

Disclosed herein is an apparatus comprising a set of acoustic sources controllable to generate an acoustic trap for suspending one or more particle(s) within the volume of the apparatus. The position of the acoustic trap within the volume of the apparatus is changed to cause a particle suspended within the acoustic trap to move around the volume of the apparatus. In particular, the acoustic field defining the acoustic trap is updated at such a rate that the particle is prevented from reaching a static equilibrium position within the acoustic trap. The apparatus may comprise a display apparatus. However, other non- display applications of such apparatus are also disclosed.

IPC Classes  ?

• G10K 15/00 - Acoustics not otherwise provided for

Abstract

The invention provides an apparatus for use in determining the three-dimensional shape of an object, which apparatus comprises: an article, comprising a stretchable material, and a plurality of strain sensors positioned in contact with the material such that stretching of the material is detectable by the sensors; a computing device operatively coupled to the article and configured to receive output data from the sensors and to process the data to determine the three dimensional shape of the object. The invention also provides a method for providing a customized orthotic product using the apparatus.

IPC Classes  ?

• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The invention provides an apparatus for use in determining the three-dimensional shape of an object, which apparatus comprises: an article, comprising a stretchable material, and a plurality of strain sensors positioned in contact with the material such that stretching of the material is detectable by the sensors; a computing device operatively coupled to the article and configured to receive output data from the sensors and to process the data to determine the three dimensional shape of the object. The invention also provides a method for providing a customized orthotic product using the apparatus.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/01 - Measuring temperature of body parts
• A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

Abstract

A method for non-invasive characterisation of a cell 2-3 for a battery, the method comprising: measuring a magnetic field generated by the cell using a plurality of magnetic field sensors 2-1 positioned adjacent to the cell, the measuring producing magnetic field sensor data, wherein the measuring is performed while the cell is in a passive state; determining current density profile data across the cell based on the magnetic field sensor data; and determining a condition of the cell using the current density profile data.

IPC Classes  ?

• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
• G01R 33/48 - NMR imaging systems
• H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells
• H01M 10/44 - Methods for charging or discharging
• G01R 31/385 - Arrangements for measuring battery or accumulator variables
• G01R 31/396 - Acquisition or processing of data for testing or for monitoring individual cells or groups of cells within a battery
• H01M 10/04 - Construction or manufacture in general
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators

Abstract

The present invention relates to a method of making a composite material, the method comprising: (1) forming a Pickering emulsion comprising a continuous liquid phase, a discontinuous liquid phase, and a 2D material; wherein the discontinuous liquid phase comprises a polysiloxane and a curing agent; (2) leaving the Pickering emulsion formed in step (1) in a sealed system for sufficient time to at least partially cure the polysiloxane; and (3) allowing any remaining liquid to evaporate.

IPC Classes  ?

• C08J 3/05 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media from solid polymers
• C08J 3/09 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in organic liquids

Abstract

The present invention relates to a method of making a composite material, the method comprising: (1) forming a Pickering emulsion comprising a continuous liquid phase, a discontinuous liquid phase, and a 2D material; wherein the discontinuous liquid phase comprises a polysiloxane and a curing agent; (2) leaving the Pickering emulsion formed in step (1) in a sealed system for sufficient time to at least partially cure the polysiloxane; and (3) allowing any remaining liquid to evaporate.

IPC Classes  ?

• C08J 3/05 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media from solid polymers
• C08J 3/09 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in organic liquids

Abstract

The present invention relates to a method for making a Pickering emulsion, the method comprising: exfoliating a non-silicate layered 3D material in a solvent to produce particles of a non-silicate unfunctionalised 2D material; forming a dispersion of the particles of the 2D material in a first liquid phase; adding a second liquid phase; and homogenising the dispersion of the 2D material in the first liquid phase with the second liquid phase to form a Pickering emulsion comprising the first liquid phase, the second liquid phase, and the particles of the 2D material.

IPC Classes  ?

• C09D 11/023 - Emulsion inks
• C01B 32/19 - Preparation by exfoliation
• C01B 32/194 - After-treatment
• C09D 11/033 - Printing inks characterised by features other than the chemical nature of the binder characterised by the solvent
• C09D 11/037 - Printing inks characterised by features other than the chemical nature of the binder characterised by the pigment
• C09D 11/101 - Inks specially adapted for printing processes involving curing by wave energy or particle radiation, e.g. with UV-curing following the printing
• C09D 11/322 - Pigment inks
• C09D 11/52 - Electrically conductive inks

Abstract

A method and a system for controlling an output of an optical system, the method comprising generating a plurality of optical signal components having different optical properties and passing the generated optical signal components as input to an optical system comprising an optical device and/or an optical medium; an output of the optical system being based on interactions of the signal components within the optical device and/or the optical medium; and relative proportions of the optical signal components that are generated and individual optical properties thereof being selected to control the output of the optical system.

IPC Classes  ?

• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
• G02F 1/35 - Non-linear optics
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• H01S 3/067 - Fibre lasers
• H01S 3/13 - Stabilisation of laser output parameters, e.g. frequency or amplitude
• H01S 3/136 - Stabilisation of laser output parameters, e.g. frequency or amplitude by controlling devices placed within the cavity

Abstract

Disclosed herein are systems using acoustic metamaterial surfaces comprising arrangements of unit cells arranged to introduce time delays to an incident acoustic wave. In embodiments the relative positions of two or more acoustic metasurfaces (81, 82) is selected or adjusted to control the acoustic output of the system such that the acoustic output of the system is a non-linear combination of the respective operations performed by the plurality of acoustic metasurfaces (81, 82), the non- linear combination being a convolution of the respective operations performed by the plurality of acoustic metasurfaces that is determined as a function of the relative positioning between the acoustic metasurfaces (81, 82). Also disclosed are applications of such acoustic metasurfaces in noise-reducing structures.

IPC Classes  ?

• G10K 11/22 - Methods or devices for transmitting, conducting or directing sound for conducting sound through hollow pipes, e.g. speaking tubes
• G10K 11/26 - Sound-focusing or directing, e.g. scanning
• G10K 11/172 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using resonance effects
• G10K 11/175 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using interference effectsMasking sound
• G10K 11/04 - Acoustic filters

Abstract

A nuclear microbattery is disclosed comprising: a radioactive material that emits photons or particles; and at least one diode comprising a semiconductor material arranged to receive and absorb photons or particles and generate electrical charge-carriers in response thereto, wherein said semiconductor material is a crystalline lattice structure comprising Aluminium, Indium and Phosphorus.

IPC Classes  ?

• G21H 1/06 - Cells wherein radiation is applied to the junction of different semiconductor materials
• G21H 1/02 - Cells charged directly by beta radiation
• G21G 4/02 - Neutron sources
• G21G 4/04 - Radioactive sources other than neutron sources
• G21H 1/10 - Cells in which radiation heats a thermoelectric junction or a thermionic converter
• G21H 1/12 - Cells using conversion of the radiation into light combined with subsequent photoelectric conversion into electric energy
• H01L 31/117 - Devices sensitive to very short wavelength, e.g. X-rays, gamma-rays or corpuscular radiation of the bulk effect radiation detector type, e.g. Ge-Li compensated PIN gamma-ray detectors
• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes

Abstract

The disclosure provides a method of producing a pharmaceutical composition. The method comprises (a) dissolving an active pharmaceutical ingredient (API) in a liquid vehicle to form a liquid medicament; (b) contacting the liquid medicament with a pharmaceutical carrier; (c) contacting the composition comprising the liquid medicament and pharmaceutical carrier with a pharmaceutical coating material to form a liqui-mass composition; and (d) pelletising the liqui-mass composition to form the pharmaceutical composition.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/20 - Pills, lozenges or tablets

Abstract

A photodiode for use in detecting X-rays and/or gamma rays is disclosed. The photodiode comprises InGaP arranged and configured to absorb X-rays and/or gamma-rays incident on the photodiode and generate charge-carriers in response thereto. The detector may be provided in an X-ray or gamma-ray photon counting spectrometer.

IPC Classes  ?

• G01T 1/24 - Measuring radiation intensity with semiconductor detectors
• G21H 1/12 - Cells using conversion of the radiation into light combined with subsequent photoelectric conversion into electric energy
• H01L 31/0203 - Containers; Encapsulations
• H01L 31/0224 - Electrodes
• H01L 31/0304 - Inorganic materials including, apart from doping materials or other impurities, only AIIIBV compounds
• H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
• H01L 31/115 - Devices sensitive to very short wavelength, e.g. X-rays, gamma-rays or corpuscular radiation

Abstract

A device (20) for manipulating an incident acoustic wave to generate an acoustic output is described wherein the device comprises a plurality of unit cells arranged into an array, at least some of said unit cells being configured to introduce time delays to an incident acoustic wave at the respective positions of the unit cells within the array of unit cells, such that said plurality of unit cells define an array of time delays to thereby define a spatial delay distribution for manipulating an incident acoustic wave to generate an acoustic output (30). The array of time delays may be re-configured to vary the spatial delay distribution of the device in order to generate different acoustic outputs. Also described are methods for designing or configuring such devices.

IPC Classes  ?

• H04R 3/12 - Circuits for transducers for distributing signals to two or more loudspeakers
• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• G01N 29/26 - Arrangements for orientation or scanning
• G10K 11/26 - Sound-focusing or directing, e.g. scanning
• H04R 1/02 - CasingsCabinetsMountings therein
• H04R 1/34 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only by using a single transducer with sound reflecting, diffracting, directing or guiding means
• H04R 1/40 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only by combining a number of identical transducers

Abstract

A system (100) for generating an olfactory experience comprises a user interface (120) that allows a user to provide a set of input parameters that define a desired olfactory experience. The system (100) further comprises a set of processing modules (104) that convert the set of input parameters into a set of scent delivery instructions for one or more scent delivery devices (106), (108) to follow. The system *100) can allow a variety of desired olfactory experiences to be indicated by a user and then allow those desired olfactory experiences (or suitable approximations or equivalents thereof) to be provided by a variety of scent delivery devices that may be available to the system (100).

IPC Classes  ?

• A61L 9/015 - Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
• A61L 9/03 - Apparatus therefor
• A61L 9/12 - Apparatus, e.g. holders, therefor
• A61L 9/14 - Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances
• G05B 15/00 - Systems controlled by a computer
• G05B 19/04 - Programme control other than numerical control, i.e. in sequence controllers or logic controllers
• H03M 7/00 - Conversion of a code where information is represented by a given sequence or number of digits to a code where the same information is represented by a different sequence or number of digits
• G06Q 10/06 - Resources, workflows, human or project managementEnterprise or organisation planningEnterprise or organisation modelling

Abstract

The invention provides compounds of the formula (I): (I) wherein A1, A2, R2, R4, B1, B2, X, X1, n, a and b are as defined are defined in the specification, to pharmaceutical compositions comprising the compounds and the compounds for use as medicaments. The compounds potentiate AMPA receptor function and are expected to be useful in the treatment of central nervous system disorders, for example in the treatment of depressive disorders, mood disorders and cognitive dysfunction associated with neuropsychiatric disorders such as schizophrenia.

IPC Classes  ?

• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 401/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 403/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 413/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
• A61P 25/24 - Antidepressants
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/18 - Antipsychotics, i.e. neurolepticsDrugs for mania or schizophrenia
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine

Abstract

A method and a system for controlling an output of an optical system, the method comprising generating a plurality of optical signal components having different optical properties and passing the generated optical signal components as input to an optical system comprising an optical device and/or an optical medium; an output of the optical system being based on interactions of the signal components within the optical device and/or the optical medium; and relative proportions of the optical signal components that are generated and individual optical properties thereof being selected to control the output of the optical system.

IPC Classes  ?

• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
• G02F 1/35 - Non-linear optics
• H01S 3/05 - Construction or shape of optical resonatorsAccommodation of active medium thereinShape of active medium
• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating

Abstract

A method and a system for controlling an output of an optical system, the method comprising generating a plurality of optical signal components having different optical properties and passing the generated optical signal components as input to an optical system comprising an optical device and/or an optical medium; an output of the optical system being based on interactions of the signal components within the optical device and/or the optical medium; and relative proportions of the optical signal components that are generated and individual optical properties thereof being selected to control the output of the optical system.

IPC Classes  ?

• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
• G02F 1/35 - Non-linear optics
• H01S 3/05 - Construction or shape of optical resonatorsAccommodation of active medium thereinShape of active medium
• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating

Abstract

The present invention relates to covalently bonded conjugates of cyclodextrins and deferasirox or an analogue thereof, pharmaceutical compositions comprising such conjugates and methods to make such conjugates. The conjugates may be useful in the treatment of various medical conditions including metal overload, such as iron overload and copper overload.

IPC Classes  ?

• A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
• C07D 249/08 - 1,2,4-TriazolesHydrogenated 1,2,4-triazoles
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a method for making a Pickering emulsion, the method comprising: exfoliating a non-silicate layered 3D material in a solvent to produce particles of a non-silicate unfunctionalised 2D material; forming a dispersion of the particles of the 2D material in a first liquid phase; adding a second liquid phase; and homogenising the dispersion of the 2D material in the first liquid phase with the second liquid phase to form a Pickering emulsion comprising the first liquid phase, the second liquid phase, and the particles of the 2D material.

IPC Classes  ?

• C01G 39/06 - Sulfides
• A61K 9/107 - Emulsions
• A61K 8/06 - Emulsions
• A61K 8/19 - Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• C01B 21/064 - Binary compounds of nitrogen with metals, with silicon, or with boron with boron
• C01G 39/00 - Compounds of molybdenum
• C01G 41/00 - Compounds of tungsten
• C09D 11/023 - Emulsion inks
• C01B 32/19 - Preparation by exfoliation
• C01B 32/194 - After-treatment
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G01L 1/00 - Measuring force or stress, in general

Abstract

The present invention relates to a method for making a Pickering emulsion, the method comprising: exfoliating a non-silicate layered 3D material in a solvent to produce particles of a non-silicate unfunctionalised 2D material; forming a dispersion of the particles of the 2D material in a first liquid phase; adding a second liquid phase; and homogenising the dispersion of the 2D material in the first liquid phase with the second liquid phase to form a Pickering emulsion comprising the first liquid phase, the second liquid phase, and the particles of the 2D material.

IPC Classes  ?

• A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• B01F 23/41 - Emulsifying
• C01B 21/00 - NitrogenCompounds thereof
• C01B 21/064 - Binary compounds of nitrogen with metals, with silicon, or with boron with boron
• C01B 25/02 - Preparation of phosphorus
• C01B 32/19 - Preparation by exfoliation
• C01B 32/194 - After-treatment
• C01B 32/914 - Carbides of single elements
• C01B 33/02 - Silicon
• C01G 1/00 - Methods of preparing compounds of metals not covered by subclasses , , , , in general
• C01G 17/00 - Compounds of germanium
• C01G 19/00 - Compounds of tin
• C01G 23/04 - OxidesHydroxides
• C01G 29/00 - Compounds of bismuth
• C01G 39/00 - Compounds of molybdenum
• C01G 39/06 - Sulfides
• C01G 41/00 - Compounds of tungsten
• C09D 11/023 - Emulsion inks
• C09K 23/00 - Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
• G01B 7/16 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring the deformation in a solid, e.g. by resistance strain gauge
• H01B 1/00 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors

Abstract

An instrument (20) determines the attitude of a spacecraft (3) on which it is mounted, by interacting incident light (11) from the Sun with one or more light conditioning elements (12) and thereby forming a diffraction pattern at a photo-sensitive detector (13). The intensity distribution of light on the detector (13) is dependent on the angle of incidence of the light (11). An on-board computer (16) determines a direction vector to the Sun based on the light diffraction pattern detected by the detector (13).

IPC Classes  ?

• G01S 3/78 - Direction-finders for determining the direction from which infrasonic, sonic, ultrasonic, or electromagnetic waves, or particle emission, not having a directional significance, are being received using electromagnetic waves other than radio waves
• G01S 5/16 - Position-fixing by co-ordinating two or more direction or position-line determinationsPosition-fixing by co-ordinating two or more distance determinations using electromagnetic waves other than radio waves
• G01S 3/786 - Systems for determining direction or deviation from predetermined direction using adjustment of orientation of directivity characteristics of a detector or detector system to give a desired condition of signal derived from that detector or detector system the desired condition being maintained automatically

Abstract

The present invention relates to a hypoxia-inducible factor (HIF) activator, or a pharmaceutically acceptable salt or solvate thereof, for use in promoting tissue repair. The HIF activator, or the pharmaceutically acceptable salt or solvate thereof, is for use with a prototypical tissue-protective cytokine, or a pharmaceutically acceptable salt or solvate thereof, which is administered exogenously to the body being treated.

IPC Classes  ?

• A61K 38/18 - Growth factorsGrowth regulators
• A61K 31/28 - Compounds containing heavy metals
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

A nuclear microbattery is disclosed comprising: a radioactive material that emits photons or particles; and at least one diode comprising a semiconductor material arranged to receive and absorb photons or particles and generate electrical charge-carriers in response thereto, wherein said semiconductor material is a crystalline lattice structure comprising Aluminium, Indium and Phosphorus.

IPC Classes  ?

• G21H 1/02 - Cells charged directly by beta radiation
• G21H 1/04 - Cells using secondary emission induced by alpha radiation, beta radiation, or gamma radiation

Abstract

A nuclear microbattery is disclosed comprising: a radioactive material that emits photons or particles; and at least one diode comprising a semiconductor material arranged to receive and absorb photons or particles and generate electrical charge-carriers in response thereto, wherein said semiconductor material is a crystalline lattice structure comprising Aluminium, Indium and Phosphorus.

IPC Classes  ?

• G21H 1/02 - Cells charged directly by beta radiation
• G21H 1/04 - Cells using secondary emission induced by alpha radiation, beta radiation, or gamma radiation

Abstract

A light pulse generating circuit is described for generating light pulses from a diode light source such as an LED or laser diode. The light pulse generating circuit comprises a charge storage device and a trigger circuit for triggering a discharge of the charge storage device across the diode light source to generate a light pulse. The light pulse generating circuit comprises a differentiator circuit for differentiating an input signal to produce a differentiated signal, which is provided as an input to the trigger circuit. A first diode is arranged relative to the differentiator circuit in order to substantially prevent the propagation of one of a positive pulse and a negative pulse generated by differentiating the input signal so that a light pulse having a single peak is generated. Also described are methods of using the same, and systems comprising a plurality of light pulse generating circuits arranged in sequence.

IPC Classes  ?

• H05B 33/08 - Circuit arrangements for operating electroluminescent light sources
• H03K 3/57 - Generators characterised by the type of circuit or by the means used for producing pulses by the use of an energy-accumulating element discharged through the load by a switching device controlled by an external signal and not incorporating positive feedback the switching device being a semiconductor device

Abstract

A photodiode for use in detecting X-rays and/or gamma rays is disclosed. The photodiode comprises In Ga P arranged and configured to absorb X-rays and/or gamma- rays incident on the photodiode and generate charge-carriers in response thereto. The detector may be provided in an X-ray or gamma-ray photon counting spectrometer.

IPC Classes  ?

• G01T 1/24 - Measuring radiation intensity with semiconductor detectors
• H01L 27/146 - Imager structures
• H01L 31/117 - Devices sensitive to very short wavelength, e.g. X-rays, gamma-rays or corpuscular radiation of the bulk effect radiation detector type, e.g. Ge-Li compensated PIN gamma-ray detectors

Abstract

The invention provides compounds of the formula (I): wherein R1 and R2 are defined in the specification, to pharmaceutical compositions comprising the compounds and the compounds for use as medicaments. The compounds potentiate AMPA receptor function and are expected to be useful in the treatment of central nervous system disorders, for example in the treatment of depressive disorders, mood disorders and cognitive dysfunction associated with neuropsychiatric disorders such as schizophrenia.

IPC Classes  ?

• C07D 403/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/24 - Antidepressants
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 31/4155 - 1,2-Diazoles not condensed and containing further heterocyclic rings

Abstract

A device (20) for manipulating an incident acoustic wave to generate an acoustic output is described wherein the device comprises a plurality of unit cells arranged into an array, at least some of said unit cells being configured to introduce time delays to an incident acoustic wave at the respective positions of the unit cells within the array of unit cells, such that said plurality of unit cells define an array of time delays to thereby define a spatial delay distribution for manipulating an incident acoustic wave to generate an acoustic output (30). The array of time delays may be re-configured to vary the spatial delay distribution of the device in order to generate different acoustic outputs. Also described are methods for designing or configuring such devices.

IPC Classes  ?

• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details
• G01N 29/26 - Arrangements for orientation or scanning
• G10K 11/34 - Sound-focusing or directing, e.g. scanning using electrical steering of transducer arrays, e.g. beam steering
• H04R 3/12 - Circuits for transducers for distributing signals to two or more loudspeakers

Abstract

An instrument (20) determines the attitude of a spacecraft (3) on which it is mounted, by interacting incident light (11) from the Sun with one or more light conditioning elements (12) and thereby forming a diffraction pattern at a photo- sensitive detector (13). The intensity distribution of light on the detector (13) is dependent on the angle of incidence of the light (11). An on-board computer (16) determines a direction vector to the Sun based on the light diffraction pattern detected by the detector (13).

IPC Classes  ?

• G01S 3/786 - Systems for determining direction or deviation from predetermined direction using adjustment of orientation of directivity characteristics of a detector or detector system to give a desired condition of signal derived from that detector or detector system the desired condition being maintained automatically
• G01S 5/16 - Position-fixing by co-ordinating two or more direction or position-line determinationsPosition-fixing by co-ordinating two or more distance determinations using electromagnetic waves other than radio waves

Abstract

The present invention relates to a method of coating a plurality of solid supports with a photocatalyst, the method comprising: dry mixing the solid supports with particulate photocatalyst in a rotating processing vessel.

IPC Classes  ?

• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/04 - Mixing
• B01J 37/06 - Washing
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 35/02 - Solids
• B01J 35/08 - Spheres
• B01J 21/06 - Silicon, titanium, zirconium or hafniumOxides or hydroxides thereof
• C01G 23/047 - Titanium dioxide
• C03C 17/00 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating
• C03C 17/23 - Oxides
• C03C 15/00 - Surface treatment of glass, not in the form of fibres or filaments, by etching
• B01J 23/30 - Tungsten
• C07D 301/08 - Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with air or molecular oxygen in the gaseous phase

Abstract

The invention relates to biological markers for distinguishing between sepsis and SIRS, and in particular to the use of micro RNAs as diagnostic markers that may be used to distinguish between sepsis and SIRS. The invention extends to methods and kits which detect for such diagnostic micro RNAs for distinguishing between sepsis and SIRS, and to methods of treatment.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The invention relates to lubricant analysis, and to apparatus and methods for carrying out real-time in situ lubricant analysis. The invention extends to apparatus and methods which can measure tribological wear in machinery and, in particular, to the in situ measurement of the elemental composition of lubricant and/or debris caught in a filter within a lubricant-wetted machine.

IPC Classes  ?

• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators
• G01N 33/28 - Oils
• G01N 23/223 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence

Abstract

Variant forms of Amyloid-beta (Aβ) and kits comprising a variant Aβ are disclosed. The invention also provides uses of these kits and the Aβ variants in Aβ studies, for example in assays and methods for screening novel compounds for use in treating Alzheimer's Disease.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

The present invention provides antifungal compositions, and in particular, to antifungal formulations comprising a combination of an antifungal active agent and an AOX inhibitor for use in treating fungal infections in plants and animals. [Figure: 8]

IPC Classes  ?

• A01N 35/04 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio-analogues thereof, directly attached to an aromatic ring system, e.g. acetophenoneDerivatives thereof, e.g. acetals
• A01N 37/46 - N-acyl derivatives
• A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
• A01N 43/54 - 1,3-DiazinesHydrogenated 1,3-diazines
• A01N 43/653 - 1,2,4-TriazolesHydrogenated 1,2,4-triazoles
• A01N 47/20 - N-Aryl derivatives thereof
• A01N 47/24 - Carbamic acid derivatives, i.e. containing the group —O—CO—NThio-analogues thereof containing the groups , or Thio-analogues thereof
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
• A01P 3/00 - Fungicides

Abstract

The present application is directed towards complexes of formula (I), to methods for preparing such complexes, and to use of such complexes in catalysis. The complexes show utility in a range of catalytic cycles, including Pd(ll)/Pd(IV) cycles. (Formula (I))

IPC Classes  ?

• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

Abstract

A continuously variable transmission (1) comprising: one or more driving members (5) coupled to an input shaft (7), wherein one or more of the driving members (5) are movable; a first carriage assembly (11) comprising one or more intermediary elements (13) disposed circumferentially at least partially within the first carriage assembly (11), wherein each of the intermediary elements (13) has a rotational axis that can be displaced in relation to the first carriage assembly (11); and a second carriage assembly (17) coupled to an output shaft (3), the second carriage assembly (17) comprising a second carriage member (18) and one or more movable driven members (19), wherein the intermediary elements (13) are configured to transmit rotational motion between the driving: members (5) and the driven members (19), the second carriage member (18) being substantially annular and comprising one or more wedging surface features (28), wherein the wedging surface features (28) comprise one or more profiled surfaces (29) that are configured to displace the driven members (19) upon movement of the second carriage member (18) in relation to the driven members (19).

IPC Classes  ?

• F16H 35/00 - Gearings or mechanisms with other special functional features
• F16H 15/50 - Gearings providing a continuous range of gear ratios
• F16H 57/04 - Features relating to lubrication or cooling

Abstract

An ion trap comprising: a first array of magnetic elements arranged to generate a first magnetic field with a degree of homogeneity; and an array of electrodes arranged to generate an electrostatic field including a turning point in electrical potential at a location where the magnetic field has a substantially maximum degree of homogeneity; wherein the array of electrodes is planar and parallel to the direction of the magnetic field at the location; and wherein a primary first magnetic element is arranged to generate a first component of the first magnetic field and other first magnetic elements are arranged to generate compensating components of the first magnetic field that reduce the gradient, the curvature and higher order derivatives of the first component of the first magnetic field at the location where the first magnetic field has the substantially maximum degree of homogeneity.

IPC Classes  ?

• H01J 49/20 - Magnetic deflection
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

The invention provides a target object detection system, comprising a plurality of sensing nodes (10) for positioning at respective detection locations with respect to a detection area (12) that is situated within a field generated by an ambient AC source of excitation. Each sensing node has at least one electric potential sensor (22, 42) designed to detect perturbations in said field caused by a target object (14), said one sensor including an electrode (20, 40) responsive to the AC excitation field for generating detection signals, an amplifier (28) connected to the electrode for receiving and amplifying the detection signals to produce AC measurement signals as output, and at least one feedback circuit (30, 36) from an output of the amplifier to an input thereof for enhancing the input impedance of the amplifier. A signal processing arrangement (24, 26, 44) is associated with each sensing node and comprising a filter circuit (24) adapted to filter out frequencies generated by the ambient AC source of excitation that are outside a pre-defined bandwidth, and a level detector (26) responsive to the AC measurement signals for monitoring signal amplitude and generating amplitude information for use in producing target object data.

IPC Classes  ?

• G01R 1/30 - Structural combination of electric measuring instruments with basic electronic circuits, e.g. with amplifier
• G01V 3/08 - Electric or magnetic prospecting or detectingMeasuring magnetic field characteristics of the earth, e.g. declination or deviation operating with magnetic or electric fields produced or modified by objects or geological structures or by detecting devices
• G08B 13/24 - Electrical actuation by interference with electromagnetic field distribution

Abstract

A communications system includes a server and a direct mode network having nodes defined by a plurality of client mobile devices, wherein each client mobile device is capable of forming a connection to one or more of the other client mobile devices of the direct mode network independently of an infrastructure to provide a connection between the nodes of the direct mode network. Some or all of the client mobile devices are also able to form a connection to the server via the infrastructure for retrieving content.

IPC Classes  ?

• H04W 4/18 - Information format or content conversion, e.g. adaptation by the network of the transmitted or received information for the purpose of wireless delivery to users or terminals
• H04W 84/22 - Self-organising networks, e.g. ad hoc networks or sensor networks with access to wired networks
• H04W 88/04 - Terminal devices adapted for relaying to or from another terminal or user
• H04L 29/08 - Transmission control procedure, e.g. data link level control procedure

Abstract

The invention provides a charged particle sensor (10) for detecting and measuring ionic current generated by charged particles resulting from ionisation processes, comprising: a housing (16), a detection electrode (14) enclosed within the housing for collecting the charged particles, and an electrometer (12) having an input connected to the detection electrode for receiving a DC input signal therefrom and an output (18) for supplying a DC measurement signal as output. The housing comprises an electrostatic screen (16) for screening the detection electrode from external electric fields, whereby to reduce the sensitivity of the detection electrode to such fields. The electrostatic screen includes an electrically conducting screening sheet (26) provided as a second electrode facing the detection electrode and formed with interstices to allow the entry of radiation into the housing, and the second electrode and the detection electrode are arranged to be maintained in use at a bias voltage with respect to one another so as to effect charge separation amongst charged particles resulting from ionisation processes and thereby produce an ionic current impinging on the detection electrode.

IPC Classes  ?

• G01T 1/185 - Measuring radiation intensity with ionisation-chamber arrangements

Abstract

The present invention relates to gold complexes that find use in therapy, particularly in treating cancer. The compounds of the invention have formula (I) wherein L denotes a phosphine or N-heterocyclic carbene ligand; A denotes SO2 or C(=O); R denotes hydrogen, alkyl, or haloalkyl; or optionally substituted (hetero)aryl; and G denotes hydrogen, alkyl, cycloalkyi, (hetero)aryl, A-R, or a group deriving from an a- or β-amino acid.

IPC Classes  ?

• C07F 9/50 - Organo-phosphines
• A61P 35/00 - Antineoplastic agents

Abstract

The invention provides compounds for use in inhibiting a microbial alternative oxidase (AOX) and/or cytochrome bc1 complex. The invention extends to the use of such inhibitors in agrochemicals and in pharmaceuticals, for treating microbial infections, including fungal infections.

IPC Classes  ?

• C07C 39/24 - Halogenated derivatives
• A01N 35/04 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio-analogues thereof, directly attached to an aromatic ring system, e.g. acetophenoneDerivatives thereof, e.g. acetals
• A61K 31/11 - Aldehydes
• C07C 69/63 - Halogen-containing esters of saturated acids
• C07C 39/373 - Halogenated derivatives with all hydroxy groups on non-condensed rings and with unsaturation outside the aromatic rings
• C07C 43/178 - Unsaturated ethers containing hydroxy or O-metal groups
• C07C 47/565 - Compounds having —CHO groups bound to carbon atoms of six-membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
• C07C 49/835 - Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
• A61P 31/04 - Antibacterial agents
• A61P 31/10 - Antimycotics
• C07C 255/53 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
• C07C 235/60 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho- position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
• A01N 49/00 - Biocides, pest repellants or attractants, or plant growth regulators containing compounds containing the group wherein m+n≥1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group wherein A means a carbon atom or Y, n ≥ 0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof

Abstract

The invention provides genetic constructs comprising a coding sequence encoding alternative oxidase, and extends to methods of producing highly active and pure recombinant alternative oxidase.

IPC Classes  ?

• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase

Abstract

The invention provides a target object detection system, comprising a plurality of sensing nodes (10) for positioning at respective detection locations with respect to a detection area (12) that is situated within a field generated by an ambient AC source of excitation. Each sensing node has at least one electric potential sensor (22, 42) designed to detect perturbations in said field caused by a target object (14), said one sensor including an electrode (20, 40) responsive to the AC excitation field for generating detection signals, an amplifier (28) connected to the electrode for receiving and amplifying the detection signals to produce AC measurement signals as output, and at least one feedback circuit (30, 36) from an output of the amplifier to an input thereof for enhancing the input impedance of the amplifier. A signal processing arrangement (24, 26, 44) is associated with each sensing node and comprising a filter circuit (24) adapted to filter out frequencies generated by the ambient AC source of excitation that are outside a pre-defined bandwidth, and a level detector (26) responsive to the AC measurement signals for monitoring signal amplitude and generating amplitude information for use in producing target object data.

IPC Classes  ?

• G01V 3/08 - Electric or magnetic prospecting or detectingMeasuring magnetic field characteristics of the earth, e.g. declination or deviation operating with magnetic or electric fields produced or modified by objects or geological structures or by detecting devices

Abstract

An ion trap comprising: a first array of magnetic elements arranged to generate a first magnetic field with a degree of homogeneity; and an array of electrodes arranged to generate an electrostatic field including a turning point in electrical potential at a location where the magnetic field has a substantially maximum degree of homogeneity; wherein the array of electrodes is planar and parallel to the direction of the magnetic field at the location; and wherein a primary first magnetic element is arranged to generate a first component of the first magnetic field and other first magnetic elements are arranged to generate compensating components of the first magnetic field that reduce the gradient, the curvature and higher order derivatives of the first component of the first magnetic field at the location where the first magnetic field has the substantially maximum degree of homogeneity.

IPC Classes  ?

• H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

The invention provides pharmaceutical compositions, medicaments and methods for use in preventing, ameliorating or treating neurodevelopmental disorders. The invention extends to novel synthetic methods for preparing active agents useful in the treatment of neurodevelopmental disorders.

IPC Classes  ?

• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
• A61P 25/18 - Antipsychotics, i.e. neurolepticsDrugs for mania or schizophrenia
• C07D 491/056 - Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Abstract

An ion trap 1 comprises a magnetic field generator 2 arranged to generate a magnetic field and an array 3 of electrodes arranged to generate an electrostatic field including a turning point in electrical potential at a location where the magnetic field is substantially homogeneous. The array of electrodes 3 is planar and parallel to the direction of the magnetic field at the location, with the result that the ion trap can be described as a coplanar waveguide Penning trap.

IPC Classes  ?

• H01J 49/38 - Omegatrons

Abstract

The present invention relates to chiral ligands deriving from a- and β-amino acids, and from metal complexes formed from the same. The ligands are useful with catalytic gold complexes, particularly Au(l) complexes.

IPC Classes  ?

• C07F 1/12 - Gold compounds

Abstract

The invention relates to novel biological markers for plasma cell disorders, such as multiple myeloma, and in particular to the use of microRNAs as diagnostic and prognostic markers in assays for detecting such disorders. The invention also relates to methods of determining the efficacy of treating a plasma cell disorder with a therapeutic agent, and kits for carrying 5 out the assays and methods. The assays are qualitative and/or quantitative, and are adaptable to large-scale screening and clinical trials.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

An apparatus for performing electrical impedance detection and ultrasound scanning of body tissue, the apparatus comprising: a container for receiving body tissue comprising, at a depth, a spacing member for contacting the body tissue;an electrode array for performing electrical impedance detection by applying a first electrical signal to the body tissue, receiving an electrical response signal characteristic of the body tissue, and providing a first output signal representative of the electrical response signal; an ultrasound transducer for performing ultrasound detection by applying a first ultrasound signal to the body tissue, receiving an ultrasound response signal characteristic of the body tissue, and providing a second output signal representative of the ultrasound response signal, wherein the ultrasound transducer and the electrode array are mounted on a rotatable element of the apparatus that moves when the depth of the container is varied, and that, is configured in use, to underlie the spacing member and to rotate with respect to the body tissue; and wherein the spacing member comprises apertures.

IPC Classes  ?

• A61B 5/053 - Measuring electrical impedance or conductance of a portion of the body
• A61B 8/14 - Echo-tomography
• A61B 8/08 - Clinical applications

Abstract

The invention relates to the production of laser light, particularly the production of laser light at variable and selected wavelengths. The tunable laser system comprises a sealed chamber (201), including an optical window, a laser diode located within the chamber and a diffraction grating located outside the chamber (203), wherein the laser diode, optical window and diffraction grating (203) are arranged such that light emitted from the laser diode can pass through the optical window to the diffraction grating (203), and wherein a thermal control means is provided to control the temperature of the laser diode, and wherein an atmosphere control means is provided for controlling the moisture content of the atmosphere within the chamber (201).

IPC Classes  ?

• H01S 5/06 - Arrangements for controlling the laser output parameters, e.g. by operating on the active medium
• H01S 5/14 - External cavity lasers
• H01S 5/022 - MountingsHousings
• H01S 5/024 - Arrangements for thermal management

Abstract

The present invention provides a sensor system and a corresponding sensing method employing the sensor system. The sensor system comprises a sensor (12) having an input (20) and an output (22), a feedback path (16) from the output to the input, and a filter (14; 92) in the feedback path. The filter comprises a narrow band filter, which is tuned or tunable to a respective one of signals that are wanted signals and signals that represent interference signals. The sensor and the filter are arranged so as to alter the relative amplitudes of the wanted signals and the interference signals in order to increase the relative amplitude of the wanted signals and reduce the relative amplitude of the interference signals.

IPC Classes  ?

• G01R 23/02 - Arrangements for measuring frequency, e.g. pulse repetition rateArrangements for measuring period of current or voltage
• H03H 11/12 - Frequency selective two-port networks using amplifiers with feedback

Abstract

A power supply system comprises an internal combustion engine (20) having a pair of opposed pistons (28, 30) and cylinder (32) within which the pistons move in use, the pistons (28, 30) and cylinder together forming a combustion chamber. The pair of opposed pistons (28, 30) and the cylinder (32) are each arranged to rotate, in use, about a common axis of rotation A with respect to an associated electric generator arrangement (22) so as to generate an electric output. The pair of opposed pistons (28, 30) are also arranged to together form a mass-elastic system that is capable of resonance and further arranged such that combustion in the combustion chamber causes the pistons (28, 30) to oscillate relative to each other about the common rotational axis (A).

IPC Classes  ?

• B60K 6/32 - Arrangement or mounting of plural diverse prime-movers for mutual or common propulsion, e.g. hybrid propulsion systems comprising electric motors and internal combustion engines the prime-movers consisting of electric motors and internal combustion engines, e.g. HEVs characterised by apparatus, components or means specially adapted for HEVs characterised by the fuel cells
• B60K 6/46 - Series type
• F01C 9/00 - Oscillating-piston machines or engines
• F02B 53/00 - Internal-combustion aspects of rotary-piston or oscillating-piston engines
• F02B 63/04 - Adaptations of engines for driving pumps, hand-held tools or electric generatorsPortable combinations of engines with engine-driven devices for electric generators

Abstract

The present invention provides an electric potential sensor for the measurement of potentials non-invasively. The sensor comprises at least one detection electrode arranged for capacitive coupling with a sample under test and for generating a measurement signal, and a sensor amplifier adapted to receive the measurement signal as input and to supply an amplified detection signal as output. Input impedance enhancing means are included for providing a high input impedance to the sensor amplifier for increasing the sensitivity of the electrode to reduced electric potentials, and a discrete pre-amplifier stage is arranged to co-operate with the sensor amplifier to reduce the input capacitance of the amplifier.

IPC Classes  ?

• G01R 27/26 - Measuring inductance or capacitanceMeasuring quality factor, e.g. by using the resonance methodMeasuring loss factorMeasuring dielectric constants
• G01R 19/00 - Arrangements for measuring currents or voltages or for indicating presence or sign thereof

Abstract

The invention provides an electric potential sensor including, at least one detection electrode arranged for capacitive coupling with a sample under test and for generating a measurement signal, and a sensor amplifier adapted to receive the measurement signal as input and to supply an amplified detection signal as output. An input impedance enhancing element provides a high input impedance to the sensor amplifier for increasing the sensitivity of the electrode to reduced electric potentials, and a feedback element applies a coherent feedback signal to the input of the sensor amplifier for enhancing the signal to noise ratio of the sensor.

IPC Classes  ?

• G01R 19/00 - Arrangements for measuring currents or voltages or for indicating presence or sign thereof
• G01R 27/26 - Measuring inductance or capacitanceMeasuring quality factor, e.g. by using the resonance methodMeasuring loss factorMeasuring dielectric constants

Abstract

A power supply system comprises an internal combustion engine (100) and an electric motor-generator arrangement that is coupled to the internal combustion engine. The internal combustion engine (100) has a piston-cylinder assembly in which the toroidal section-shaped piston (122) and cylinder (120) are each arranged to rotate, in use, about a common axis of rotation B with respect to a stator arrangement (129) of the associated motor-generator arrangement so as to generate an electric output. The piston (122) and cylinder (120) are also arranged to form a mass-elastic system that is capable of resonance and further arranged such that combustion in the combustion chamber (121) formed between the cylinder (120) and piston (122) can cause the piston (122) and cylinder (120) to oscillate relative to each other about their common rotational axis B.

IPC Classes  ?

• F02B 55/00 - Internal-combustion aspects of rotary pistonsOuter members for co-operation with rotary pistons
• F02B 63/04 - Adaptations of engines for driving pumps, hand-held tools or electric generatorsPortable combinations of engines with engine-driven devices for electric generators
• F02D 15/02 - Varying compression ratio by alteration or displacement of piston stroke
• F02B 53/02 - Methods of operating
• F01C 9/00 - Oscillating-piston machines or engines

Abstract

The present invention provides a sensor system and a corresponding sensing method employing the sensor system. The sensor system comprises a sensor (12) having an input (20) and an output (22), a feedback path (16) from the output to the input, and a filter (14; 92) in the feedback path. The filter comprises a narrow band filter, which is tuned or tunable to a respective one of signals that are wanted signals and signals that represent interference signals. The sensor and the filter are arranged so as to alter the relative amplitudes of the wanted signals and the interference signals in order to increase the relative amplitude of the wanted signals and reduce the relative amplitude of the interference signals.

IPC Classes  ?

• H03H 11/12 - Frequency selective two-port networks using amplifiers with feedback

Abstract

Medical image data is analysed to produce a biomarker. The data is filtered with a plurality of band-pass filters each having a different bandwidth. A texture parameter is then determined from the filtered data from each filter and the biomarker is determined as at a ratio of the texture parameters. When the biomarker is obtained from a CT image of a liver, it can be predictive of poor survival, disease extent and liver physiology of a patient following resection of colorectal cancer. When obtained from a mammographic image, the biomarker can be indicative of cancer invasion and receptor status within mammographic abnormalities. When obtained from a CT image of a lung nodule, the biomarker can be predictive of tumour stage (or grading) and tumour metabolism of a patient with non-small cell lung carcinoma (lung cancer). When obtained from an MRI image of the brain, the biomarker can be indicative of schizophrenia and/or other brain disorders.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

Abstract

A vehicle power supply system comprises an internal combustion engine (1) and a steam generator (2) arranged in a 'closed system'. Water, or another suitable working fluid, is supplied to the steam generator (2) whereupon it is heated using exhaust heat from the internal combustion engine (1). The steam that is generated is stored in a storage tank (3) until a later time, e.g. when the internal combustion engine (1) is not running, whereupon the steam is used to provide heat and/or power to vehicle. For example, the steam can be used to drive a generator (5), via an expander (4), to provide electricity for powering various electrical systems within the vehicle. Additionally, the hot exhaust (7) from the expander (4) can be supplied to a radiator (8) to provide heating for the vehicle cabin.

IPC Classes  ?

• B60H 1/00 - Heating, cooling or ventilating devices
• F01N 5/02 - Exhaust or silencing apparatus combined or associated with devices profiting by exhaust energy the devices using heat
• F25B 27/02 - Machines, plants or systems, using particular sources of energy using waste heat, e.g. from internal-combustion engines

Abstract

The invention provides an electric potential sensor, comprising at least one detection electrode (12) arranged for capacitive coupling with a sample under test and for generating a measurement signal, and a sensor amplifier (14) adapted to receive the measurement signal as input and to supply an amplified detection signal as output. Input impedance enhancing (34) means provide a high input impedance to the sensor amplifier for increasing the sensitivity of the electrode to reduced electric potentials, and feedback means (46, 52, 54, 56; 56, 61) apply a coherent feedback signal to the input of the sensor amplifier for enhancing the signal to noise ratio of the sensor.

IPC Classes  ?

• G01R 19/00 - Arrangements for measuring currents or voltages or for indicating presence or sign thereof

Abstract

A device for manipulating the properties of a laser beam comprises a glass- block or slab (7) that is mounted on a piezo-electric crystal. The piezo-electric crystal is arranged so as to vibrate the block or slab (7) in a linear reciprocating fashion along a direction (8). This motion of the glass block or slab 7 causes Fresnel drag on a laser beam passing through the glass block (7), thereby inducing a phase (and frequency) shift in the beam as it passes through the block or slab (7), which is proportional to the velocity of the block or slab (7). This can be used to, e.g., dither the frequency or phase of the beam in use.

IPC Classes  ?

• G01C 19/72 - Gyrometers using the Sagnac effect, i.e. rotation-induced shifts between counter-rotating electromagnetic beams with counter-rotating light beams in a passive ring, e.g. fibre laser gyrometers

Abstract

A power supply system comprises an internal combustion engine (1) and a fuel cell (2) arranged in series with each other, together with an appropriate fuel supply (6) and an air supply (3) for the fuel cell (2) and internal combustion engine (1). The stream of fuel gas (7) which is exhausted from the anode of the fuel cell (2) is provided as a fuel supply input to the fuel supply system of the internal combustion engine (1). The voltage and current profile along the fuel cell (2) is determined in use so as to determine the composition of the fuel supply stream (6) that is input to the fuel cell (2). This allows the nature, e.g., quality, of the supplied fuel to be determined.

IPC Classes  ?

• H01M 8/04 - Auxiliary arrangements, e.g. for control of pressure or for circulation of fluids
• B60L 11/00 - Electric propulsion with power supplied within the vehicle (B60L 8/00, B60L 13/00 take precedence;arrangements or mounting of prime-movers consisting of electric motors and internal combustion engines for mutual or common propulsion B60K 6/20)

Abstract

A power supply system comprises an internal combustion engine (1) and a fuel cell (2) arranged in series with each other, together with an appropriate fuel supply (6) and an air supply (3) for the fuel cell (2) and internal combustion engine (1). The stream of fuel gas (7) which is exhausted from the anode of the fuel cell (2) is provided as a fuel supply input to the fuel supply system of the internal combustion engine (1). The fuel cell (2) is controlled so as to control the composition of exhausted fuel supply stream (7) that is input from it into the internal combustion engine (1). This is achieved by controlling the fuel cell (2) to remove (consume) a desired amount of the combustible. material (fuel) in the fuel supplied to it, before that fuel is supplied to the internal combustion engine.

IPC Classes  ?

• H01M 8/04 - Auxiliary arrangements, e.g. for control of pressure or for circulation of fluids
• H01M 8/06 - Combination of fuel cells with means for production of reactants or for treatment of residues
• H01M 8/00 - Fuel cellsManufacture thereof
• B60L 11/00 - Electric propulsion with power supplied within the vehicle (B60L 8/00, B60L 13/00 take precedence;arrangements or mounting of prime-movers consisting of electric motors and internal combustion engines for mutual or common propulsion B60K 6/20)

Abstract

The present invention provides an electric potential sensor (28) for the measurement of potentials non-invasively. The sensor comprises at least one detection electrode (12) arranged for capacitive coupling with a sample under test and for generating a measurement signal, and a sensor amplifier (14) adapted to receive the measurement signal as input and to supply an amplified detection signal as output. Input impedance enhancing means (12a, 32, 36, 38, 44) are included for providing a high input impedance to the sensor amplifier for increasing the sensitivity of the electrode to reduced electric potentials, and a discrete pre-amplifier stage (30) is arranged to co-operate with the sensor amplifier to reduce the input capacitance of the amplifier.

IPC Classes  ?

• G01R 29/12 - Measuring electrostatic fields
• G01R 19/00 - Arrangements for measuring currents or voltages or for indicating presence or sign thereof

Abstract

The present invention provides nuclear magnetic resonance apparatus comprising means for applying a static magnetic field (H0) to a sample (12) under investigation, a radio frequency circuit (14) arranged to be inductively coupled to the sample by means of an oscillating magnetic field disposed generally perpendicular to the static magnetic field for applying an excitation signal to the sample, and an electric potential sensor (E1, E2) for detecting the excitation of the sample and for generating a detection output. The electric potential sensor (E) comprises an electrode (22) placed generally perpendicular to the axis of the oscillating magnetic field for capacitively coupling the electric potential sensor to the sample.

IPC Classes  ?

• G01R 33/32 - Excitation or detection systems, e.g. using radiofrequency signals
• G01R 5/28 - Electrostatic instruments
• G01R 29/12 - Measuring electrostatic fields
• G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance

Abstract

A system for optimising electronic circuits to be designed has two parts or phases, a training phase 10 in which optimisation scenarios for selected electronic circuits are derived using an evolutionary algorithm, and an operation phase 11, in which the derived optimisation scenarios are used to optimise new electronic circuits to be designed. The training phase 10 uses an evolutionary algorithm to produce a specialised and relatively fast optimisation scenario for each of a plurality of input circuits or groups of circuits (step 13). One or more of the evolved specialist optimisation scenarios are then selected to form a suite of optimisation scenarios (step 15) for use to optimise new circuits to be designed. In the operation phase 11, a new circuit to be optimised is input at step 18, and a plurality of optimisation scenarios from the suite of optimisation scenarios 15 is then used to try to optimise the new circuit (step 19). The best optimisation result is taken as the optimisation for the circuit (step 20).

IPC Classes  ?

• G06F 17/50 - Computer-aided design

Abstract

Haem-based peroxidases modified at positions (38, 41) and (42), in relation to horseradish peroxidase, show stereoselectivity and activity similar to that of the cytochromes P450 and chloroperoxidase, but without the necessity for ancillary enzymes or reagents.

IPC Classes  ?

• C12N 9/08 - Oxidoreductases (1.), e.g. luciferase acting on hydrogen peroxide as acceptor (1.11)
• C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor

Goods & Services

Glassware; tableware; kitchenware; mugs and tankards; plates; ornaments included in this class; pottery; porcelain ware; coasters; corkscrews; combs and hairbrushes. University education services, academic and vocational education services; provision of courses of instruction, lectures and seminars all relating to academic or vocational subjects; educational examination services; conferral of degrees and diploma certificates; arranging and conducting conferences and seminars; library services; publication of books, texts, journals, reports, magazines and leaflets; videotape film production; provision of distance learning courses; provision of recreational and sporting facilities; educational research and consultancy. Scientific and technological research; scientific and technological consultancy.

Goods & Services

Glassware; tableware; kitchenware; mugs and tankards; plates; ornaments included in this class; pottery; porcelain ware; coasters; corkscrews; combs and hairbrushes. University education services, academic and vocational education services; provision of courses of instruction, lectures and seminars all relating to academic or vocational subjects; educational examination services; conferral of degrees and diploma certificates; arranging and conducting conferences and seminars; library services; publication of books, texts, journals, reports, magazines and leaflets; videotape film production; provision of distance learning courses; provision of recreational and sporting facilities; educational research and consultancy. Scientific and technological research; scientific and technological consultancy.