The present disclosure relates to organosilicon preceramic resin compositions for forming porous polymer-derived ceramic materials. It also relates to porous organosilicon polymer-derived ceramic materials, and methods for forming porous organosilicon polymer-derived ceramic materials.
C08G 77/20 - Polysiloxanes containing silicon bound to unsaturated aliphatic groups
C08G 77/28 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen sulfur-containing groups
The present disclosure relates to organosilicon preceramic resin compositions for forming polymer-derived ceramic materials, especially high-shrinkage polymer-derived ceramic materials. It also relates to organosilicon polymer-derived ceramic materials articles and methods for their formation.
C04B 35/571 - Fine ceramics obtained from polymer precursors
C03C 10/00 - Devitrified glass ceramics, i.e. glass ceramics having a crystalline phase dispersed in a glassy phase and constituting at least 50% by weight of the total composition
C04B 35/14 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on silica
C04B 35/56 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbides
The present disclosure relates to resins for forming electrically conductive polymeric or polymer-derived ceramic (PDC) materials, the resins comprising: a photopolymerisable organosilicon monomer; and a conductivity additive. Also disclosed are electrically conductive polymeric or PDC materials, polymeric materials for forming electrically conductive PDC materials, and methods of formation of these materials.
C04B 35/571 - Fine ceramics obtained from polymer precursors
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
C04B 38/08 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof by adding porous substances
C08G 77/20 - Polysiloxanes containing silicon bound to unsaturated aliphatic groups
C08G 77/28 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen sulfur-containing groups
C08G 77/60 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon in which all the silicon atoms are connected by linkages other than oxygen atoms
C08L 83/06 - Polysiloxanes containing silicon bound to oxygen-containing groups
C08L 83/08 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen
C08L 83/16 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon onlyCompositions of derivatives of such polymers in which all the silicon atoms are connected by linkages other than oxygen atoms
4.
BIO-MONOMERS, POLYMERS AND METHODS OF PREPARING THE SAME
The present invention relates to bio-monomers and bio-polymers produced from said monomers. The invention also relates to methods for producing both the monomeric and polymeric compounds that are substantially optically transparent and biodegradable.
A hybrid Direct Ink Writing and photo-curing system and methods of using same, including a method for fabricating a three-dimensional object layer-by-layer upon a work surface using one or more photocurable inks, the work surface configured to be moveable relative to an ink deposition arrangement and a light source, the method comprising forming a layer of the three-dimensional object, said forming of a layer comprising: depositing photocurable ink; and selectively exposing the deposited ink to the light source, to thereby cure at least a portion of the deposited ink; the cured portion forming at least part of a layer of the three-dimensional object.
B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation
B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
B29C 64/129 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
C09D 11/101 - Inks specially adapted for printing processes involving curing by wave energy or particle radiation, e.g. with UV-curing following the printing
C09D 11/102 - Printing inks based on artificial resins containing macromolecular compounds obtained by reactions other than those only involving unsaturated carbon-to-carbon bonds
An acoustic sensing system is provided for generating an acoustic map to identify one or more sounds sources in an area of interest comprising an acoustic sensor array comprising a plurality of acoustic sensor elements arranged in an initial configuration, each acoustic sensor element being configured to receive acoustic data from the area of interest including the one or more sound sources; an optical imaging apparatus comprising an image sensor configured to receive optical image data representative of the area of interest; one or more processors in communication with the acoustic sensor array and the optical imaging apparatus, the processor configured to generate an acoustic map that includes the acoustic data and the optical image data; determine an optimised configuration of acoustic sensor elements to enhance the acoustic map; cause the acoustic sensor elements to be arranged into the optimised configuration; and generate an optimised acoustic map that includes the acoustic data received from the acoustic sensor elements arranged in the optimised configuration together with the optical image data; wherein the optimised configuration includes adjustments to the acoustic sensor elements to focus on a particular sound source or enhance focus on one or more selected sound sources. A method for generating an acoustic map to identify one or more sound sources in an area of interest is also provided.
H04R 1/40 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only by combining a number of identical transducers
G01H 17/00 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves, not provided for in the other groups of this subclass
G01S 3/808 - Systems for determining direction or deviation from predetermined direction using transducers spaced apart and measuring phase or time difference between signals therefrom, i.e. path-difference systems
G01S 5/00 - Position-fixing by co-ordinating two or more direction or position-line determinationsPosition-fixing by co-ordinating two or more distance determinations
H04N 5/93 - Regeneration of the television signal or of selected parts thereof
H04R 1/22 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired frequency characteristic only
Provided herein are recombinant adenoviruses comprising: (a) a modified E1 coding region; (b) an inactive E3 coding region; (c) a HLA-A*02:01 open reading frame; and (d) an immunopeptide sequence present in a capsid protein encoding region, wherein the immunopeptide sequence comprises a p53-derived immunopeptide.
Methods and systems for the transfer of samples collected on swabs (or similar sample collectors) onto particular types of substrates for subsequent analysis or other processing. The method involves contacting the sample collector containing a sample including the charged substance with the electrophoresis matrix; applying an electric field across the electrophoresis matrix to effect transfer of the charged substance from the sample collector to the electrophoresis matrix. The useful systems may assist in the performance of an operation on a charged substances within an electrophoresis system. Such systems may include a first electrolyte reservoir including a first electrode; a second electrolyte reservoir including a second electrode; a thread extending between the first and second electrolyte reservoirs; a third reservoir through which the thread passes, and a controller for controlling the application of an electric field across the thread so as to effect movement of a charged substance along the thread.
The present disclosure relates to methods of identifying, differentiating between and/or sorting sperm cells, or more particularly, X-chromosome bearing sperm (X-CBS) and Y-chromosome bearing sperm (Y-CBS) cells, in a sperm sample, the methods comprising determining a level of a Reactive Oxidant Species and/or a Cellular Change mediated thereby (ROSCC) in each of a plurality of sperm cells in the sperm sample; and based on the determined ROSCC levels, identifying, differentiating between and/or sorting X-CBS and Y-CBS cells in at least a portion of the plurality of sperm cells. Also described are enriched or purified X-CBS and Y-CBS cells, and uses thereof.
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G01N 33/533 - Production of labelled immunochemicals with fluorescent label
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
The present invention relates generally to porphyrin derivatives and their use in detecting poly- and perfluoroalkyl substances (PFAS). In particular, the present invention is directed to porphyrin derivatives having at least one receptor arm comprising an anion binding group substituted with a poly- or perfluorinated aliphatic group and their use as sensors for the detection of PFAS.
C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators
The present disclosure relates to a method of separation of charged substances by electrophoresis by using an inorganic thread. It includes contacting an electrolyte with an outer surface of the inorganic thread to cause wetting the outer surface of the inorganic thread and wicking along the inorganic thread, loading the charged substances into the electrolyte wetting the outer surface of the inorganic thread in the region of a loading zone portion of the inorganic thread and applying an electric field across the length of inorganic thread to cause the charged substances to be separated along the inorganic thread under the influence of the electric field. The present disclosure also relates to a method for the electrophoretic transfer of a charged substance from a sample on a sample applicator to an inorganic thread and to a method of stripping an outer surface coating from an inorganic thread having an outer surface coating. Related systems and components are also disclosed.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A61B 10/02 - Instruments for taking cell samples or for biopsy
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
12.
METHODS AND APPARATUS FOR REDUCING CANNIBALISM IN CRUSTACEAN
The present invention relates to methods and apparatus for reducing cannibalism in crustacean populations and in particular crustacean populations which are farmed in commercial scale aquaculture set ups.
An oscillating water column pump operable to draw water upwardly from a first depth and deposit it at a second shallower depth. The pump comprises: a chamber configured to be partially submerged in a body of water such that an open bottom of the chamber is below water level so as to trap a pocket of air thereabove within the chamber; a one-way air outlet through which air trapped in the chamber is forced out when the water level within the chamber rises and inhibits the return of air into the chamber when the water level falls, thereby creating a vacuum within the chamber above the water level; and a conduit configured to draw water at the first depth upwardly and deposit it at the second depth. The suction in the chamber causes the water to be drawn up the conduit from the first depth to the second depth.
F03B 13/14 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates characterised by using wave or tide energy using wave energy
PantoeaPantoea, deposited under Accession Number V22/011015 on 9 June 2022 with the National Measurement Institute, Australia, is provided. Methods for promoting plant growth, promoting plant tuber growth, inhibiting plant root infection by a pathogen, and inhibiting plant root disease by a pathogen, using the bacterial strains and compositions are also provided
The present disclosure relates to a method for the production of an inner surface coating on an enclosed article, such as a capillary, the method comprising vaporizing a first monomer and reacting the vaporized first monomer with the inner surface of an enclosed article to provide a monomer layer on the inner surface of the enclosed article. Also disclosed are coated enclosed articles and apparatus for performing the method..
C08G 69/32 - Polyamides derived from amino carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids from aromatic diamines and aromatic dicarboxylic acids with both amino and carboxylic groups aromatically bound
The present disclosure relates to organosilicon preceramic resin compositions for forming polymer-derived ceramic materials, especially high-shrinkage polymer-derived ceramic materials. It also relates to organosilicon polymer-derived ceramic materials articles and methods for their formation.
C04B 35/571 - Fine ceramics obtained from polymer precursors
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
C08G 77/20 - Polysiloxanes containing silicon bound to unsaturated aliphatic groups
C08G 77/24 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen halogen-containing groups
C08L 83/06 - Polysiloxanes containing silicon bound to oxygen-containing groups
C08L 83/08 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen
18.
PRECERAMIC RESINS AND POROUS POLYMER-DERIVED CERAMICS
The present disclosure relates to organosilicon preceramic resin compositions for forming porous polymer-derived ceramic materials. It also relates to porous organosilicon polymer-derived ceramic materials, and methods for forming porous organosilicon polymer-derived ceramic materials.
C04B 35/571 - Fine ceramics obtained from polymer precursors
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
C04B 35/14 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on silica
C04B 35/589 - Fine ceramics obtained from polymer precursors
C04B 38/00 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof
C04B 38/08 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof by adding porous substances
C08G 77/20 - Polysiloxanes containing silicon bound to unsaturated aliphatic groups
C08G 77/24 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen halogen-containing groups
C08G 77/60 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon in which all the silicon atoms are connected by linkages other than oxygen atoms
C08L 83/06 - Polysiloxanes containing silicon bound to oxygen-containing groups
C08L 83/08 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen
C08L 83/16 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon onlyCompositions of derivatives of such polymers in which all the silicon atoms are connected by linkages other than oxygen atoms
A23K 10/22 - Animal feeding-stuffs from material of animal origin from fish
A23K 10/30 - Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hayAnimal feeding-stuffs from material of fungal origin, e.g. mushrooms
A filter system for filtering particles from an inlet flow of fluid to an instrument for analysis of the fluid, the filter system comprising: a hydrocyclone for separating a feed stream into an overflow stream and an underflow stream; and an H-filter for performing filtration on the overflow stream by diffusion to form a purified stream.
The present application relates to methods and systems for the transfer of samples collected on swabs (or similar sample collectors) onto particular types of substrates for subsequent analysis or other processing. The method involves contacting the sample collector containing a sample including the charged substance with the electrophoresis matrix; applying an electric field across the electrophoresis matrix to effect transfer of the charged substance from the sample collector to the electrophoresis matrix. The present application also relates to useful systems, components and processes that may assist in the performance of an operation on a charged substances within an electrophoresis system. Such systems may comprise a first electrolyte reservoir comprising a first electrode; a second electrolyte reservoir comprising a second electrode; a thread extending between the first and second electrolyte reservoirs; a third reservoir through which the thread passes, and a controller for controlling the application of an electric field across the thread so as to effect movement of a charged substance along the thread. The third reservoir may be a sample loading reservoir for loading sample onto the thread, or an operation reservoir within which an operation is performed on the charged substance. The system allows for charged substances to be taken along the thread and then subjected to an operation within a reservoir in a second location.
The present invention relates generally to porphyrin derivatives and their use in detecting poly- and perfluoroalkyl substances (PFAS). In particular, the present invention is directed to porphyrin derivatives having at least one receptor arm comprising an anion binding group substituted with a poly- or perfluorinated aliphatic group and their use as sensors for the detection of PFAS.
C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
A pen format liquid collection device includes an elongate generally tubular housing (12, 112, 212, 312) able to be held by hand and having an opening at one end, and at least one liquid take-up element (30, 130, 230, 330) mounted in the housing so as to be positioned or positionable to project at the opening, the at least one liquid take-up element then further postionable by hand manipulation of the housing to contact a volume of liquid to thereby take-up a sample of the liquid to be analysed. At least one retention element (230a, 330a) is supported in the housing. The at least one liquid take-up element and the at least one retention element are arranged whereby they are relatively movable into contact, and the at least one retention element is adapted on contact to in turn take-up the sample and retain the sample or a component thereof for in situ analysis or later recovery while protected within the housing. The liquid take-up element is preferably a capillary.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
This disclosure relates generally to base editing proteins comprising a Cas9 domain and a deaminase domain, and uses therefor. In particular, the proteins of the present disclosure are adenosine base editors (ABEs) and cytidine base editors (CBEs) with improved on-target efficiency and precision, useful for clinical applications.
The invention relates to the field of food supplement manufacture and therapeutic manufacture. In particular, the invention relates to use of a prebiotic whole plant fibre extract from sugarcane in the diet of an individual for the prophylaxis and/or treatment of Inflammatory Bowel Disease. The invention also relates to a combination of the prebiotic whole plant fibre extract from sugarcane and probiotic strains, the synbiotic use of said combination in the diet of an individual, and the improved outcomes of the synbiotic approach in the prophylaxis and/or treatment of Inflammatory Bowel Disease.
A61K 35/742 - Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A23L 33/22 - Comminuted fibrous parts of plants, e.g. bagasse or pulp
The Flinders University of South Australia (Australia)
The Council of the Queensland Institute of Medical Research (Australia)
University of Tasmania (Australia)
Southern Adelaide Local Health Network (Australia)
Inventor
Craig, Jamie Evan
Macgregor, Stuart
Hewitt, Alex William
Abstract
The present disclosure relates to methods and systems for assessing the risk of glaucoma in a subject. In certain embodiments, the present disclosure provide a method of assessing the risk of primary open angle glaucoma in a subject, the method comprises determining a risk score for primary open angle glaucoma in the subject on the basis of the genetic content of the subject at a plurality of selected genetic loci or markers and thereby assessing the risk of primary open angle glaucoma in the subject, wherein the selected genetic loci or markers comprise (i) genetic loci or markers having an association with glaucoma, and/or (ii) genetic loci or markers having an association with increased intraocular pressure, and/or (iii) genetic loci or markers having an association with an increased vertical cup to disk ratio, and/or (iv) genetic loci or markers having an association with a multi-trait test of glaucoma, intraocular pressure and vertical cup to disc ratio. Other embodiments are described.
G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
A 3D printed porous membrane and a method of producing same. The method including depositing an array of droplets of a first curable material and droplets of a second curable material across a build plane, wherein the first material is insoluble in a solvent and the second material is soluble in the solvent; flattening the droplets of the first and second material so that a plurality of droplets of the first material are intermixed with a plurality of droplets of the second material; curing the first and second material to form a layer of rigid material; depositing, flattening and curing further arrays of droplets on top of the layer of rigid material to form a 3D structure; soaking the 3D structure in the solvent to at least partially dissolve the second material and producing a 3D printed porous membrane made of the first material.
B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
B29C 64/40 - Structures for supporting 3D objects during manufacture and intended to be sacrificed after completion thereof
A method for transforming a cell with a nucleic acid molecule, comprising applying a voltage to a solution comprising (i) the cell; (ii) the nucleic acid molecule; (iii) a leading electrolyte; and (iv) a terminating electrolyte; wherein when the nucleic acid molecule is single-stranded, the nucleic acid molecule comprises at least 25 bases.
The invention relates to compounds of Formula (I) and methods for their preparation. Also described are pharmaceutical compositions comprising a compound of Formula (I) and their use in the treatment or prevention of conditions associated with mitochondrial dysfunction. Formula (I)
C07C 233/51 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
A61P 25/00 - Drugs for disorders of the nervous system
30.
Liquid-liquid mixing device suitable for sample preparation by liquid-liquid extraction
A liquid-liquid mixing device (10, 210) includes a barrel (20, 220) with a liquid port (23) at or adjacent one end. A plunger assembly (30) is reciprocably moveable along an axis in the barrel (20, 220) and includes a seal member (31, 231) and an agitator (50, 250). The seal member (31, 231) is in sealingly slidable engagement with the internal wall of the barrel (20, 220) to define a variable volume chamber (24, 224) therein in communication with the liquid port. The agitator (50, 250) is reciprocably moveable in the variable volume chamber (24, 224), which agitator (50, 250) includes one or more end to end passages (54) through which liquid in the chamber (24, 224) is forced as the agitator (250) reciprocates in the chamber (24, 224). The device (10) also includes a mode selector mechanism (60, 28, 46, 64, 65, 90, 92, 94, 96) for selection between at least two modes of operation for the plunger assembly, wherein the mode selector mechanism (60, 28, 46, 64, 65, 90, 92, 94, 96) is adjustable between two or more modes whereby movement of the plunger assembly (30) effects either movement of the agitator (50, 250) with the seal member (31, 231) or movement of the agitator (50, 250) relative to the seal member (31, 231), depending on the selected mode.
B01F 31/441 - Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
B01F 23/40 - Mixing liquids with liquidsEmulsifying
G01N 1/38 - Diluting, dispersing or mixing samples
B01F 23/43 - Mixing liquids with liquidsEmulsifying using driven stirrers
B01F 23/451 - Mixing liquids with liquidsEmulsifying using flow mixing by injecting one liquid into another
The present application relates to processes for modifying the distribution of a compound in a solution comprising drawing the solution comprising the compound into an electroseparation syringe comprising a syringe barrel, a plunger and electrodes positioned to apply a voltage across solution contained in the syringe barrel, and applying a voltage across the solution in the syringe barrel to modify the distribution of the compound within the solution contained in the syringe barrel. The process may be performed as a part of an analytical process. Also described is an electroseparation syringe for performing such processes, and an apparatus for analysing a sample, the apparatus comprising: - an electroseparation syringe comprising a syringe barrel, a plunger and a pair of electrodes positioned to enable a voltage to be applied across any liquid contained within the syringe barrel, or a receiver for receiving an electroseparation syringe; - a power supply for supplying a voltage potential; - a plunger controller for operation of the plunger to draw up and dispense liquid into the syringe barrel; - an analyser for analysing liquid delivered to the analyser; - a sample reservoir for holding solution to be subjected to analysis; - a valve in fluid connection with the electroseparation syringe that enables fluid flow between the electroseparation syringe and the analyser and fluid flow between the electroseparation syringe and the sample reservoir; and - a controller for controlling operation of the power supply to the electrodes, operation of the plunger to draw liquids into the syringe barrel and dispense liquids from the syringe barrel, and to control the valve setting for controlling the direction of fluid flow.
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA (Australia)
THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH (Australia)
UNIVERSITY OF TASMANIA (Australia)
SOUTHERN ADELAIDE LOCAL HEALTH NETWORK (Australia)
Inventor
Macgregor, Stuart
Hewitt, Alex William
Abstract
The present disclosure relates to methods and systems for assessing the risk of glaucoma in a subject. In certain embodiments, the present disclosure provide a method of assessing the risk of primary open angle glaucoma in a subject, the method comprises determining a risk score for primary open angle glaucoma in the subject on the basis of the genetic content of the subject at a plurality of selected genetic loci or markers and thereby assessing the risk of primary open angle glaucoma in the subject, wherein the selected genetic loci or markers comprise (i) genetic loci or markers having an association with glaucoma, and/or (ii) genetic loci or markers having an association with increased intraocular pressure, and/or (iii) genetic loci or markers having an association with an increased vertical cup to disk ratio, and/or (iv) genetic loci or markers having an association with a multi-trait test of glaucoma, intraocular pressure and vertical cup to disc ratio. Other embodiments are described.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
33.
PREPARATION FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE USING A WHOLE PLANT FIBRE EXTRACT FROM SUGARCANE
The invention relates to the field of food supplement manufacture and therapeutic manufacture. In particular, the invention relates to use of a prebiotic whole plant fibre extract from sugarcane in the diet of an individual for the prophylaxis and/or treatment of Inflammatory Bowel Disease. The invention also relates to a combination of the prebiotic whole plant fibre extract from sugarcane and probiotic strains, the synbiotic use of said combination in the diet of an individual, and the improved outcomes of the synbiotic approach in the prophylaxis and/or treatment of Inflammatory Bowel Disease.
The invention relates generally to sorbents and sorption devices for extracting compounds. The invention relates to a sorbent comprising a polymer and microdiamond. The invention also relates to a sorption device comprising the sorbent. The invention further relates to methods of using the sorption device for extracting organic compounds from a fluid and for preparing a sample containing organic compounds for analysis.
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01D 15/08 - Selective adsorption, e.g. chromatography
A system for the separation and detection of inorganic anions in a sample, the system comprising: a separation channel with an inner coating of three or more alternating layers of a cationic polymer (e.g. hexadimethine bromide) and an anionic polymer (e.g. polystyrene sulfonate), wherein the first layer and the final layer are cationic polymer layers; a detector for detecting inorganic anions that pass through a detection zone of the separation channel; an injection system for injecting fluids including sample solutions and background electrolyte into an inlet end of the separation channel; wherein the background electrolyte comprises polyethyleneimine. Also described are corresponding methods, separation capillaries and cartridges for use in the system.
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
Goods & Services
Computer hardware and software; educational, training and
instructional manuals in electronic format. Educational materials (other than apparatus) for use in
teaching, including examination papers; educational,
training and instructional materials in printed form;
stationery; printed matter, including books, booklets,
leaflets and brochures; paper, cardboard; photographs;
educational, training and instructional materials. Organising, conducting, providing and providing information
in relation to educational, training and instructional
services, including educational courses, seminars, lectures,
tutorials, examinations and other educational resources
provided via a computer network; organising, conducting,
providing and providing information in relation to seminars,
lectures, tutorials, examinations, colloquiums, conferences,
congresses and symposia; publication of educational,
training and instructional materials and other books, texts
and audio-visual materials; providing facilities or services
for study, education, instruction, teaching and training;
conducting and administering examinations and providing
facilities or services for the conduct and administration of
examinations.
37.
LIQUID-LIQUID MIXING DEVICE SUITABLE FOR SAMPLE PREPARATION BY LIQUID-LIQUID EXTRACTION
A liquid-liquid mixing device (10, 210) includes a barrel (20, 220) with a liquid port (23) at or adjacent one end. A plunger assembly (30) is reciprocably moveable along an axis in the barrel (20, 220) and includes a seal member (31, 231) and an agitator (50, 250). The seal member (31, 231) is in sealingly slidable engagement with the internal wall of the barrel (20, 220) to define a variable volume chamber (24, 224) therein in communication with the liquid port. The agitator (50, 250) is reciprocably moveable in the variable volume chamber (24, 224), which agitator (50, 250) includes one or more end to end passages (54) through which liquid in the chamber (24, 224) is forced as the agitator (250) reciprocates in the chamber (24, 224). The device (10) also includes a mode selector mechanism (60, 28, 46, 64, 65, 90, 92, 94, 96) for selection between at least two modes of operation for the plunger assembly, wherein the mode selector mechanism (60, 28, 46, 64, 65, 90, 92, 94, 96) is adjustable between two or more modes whereby movement of the plunger assembly (30) effects either movement of the agitator (50, 250) with the seal member (31, 231) or movement of the agitator (50, 250) relative to the seal member (31, 231), depending on the selected mode.
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/08 - Measuring devices for evaluating the respiratory organs
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
39.
DEVICE AND METHOD FOR INTERFACING TWO SEPARATION TECHNIQUES
The present invention relates to an evaporative membrane concentration device adapted to interface two liquid flow processes, such as two low or high resolution separation techniques or a low or high resolution separation technique and a liquid flow detection technique. For example, the two liquid flow processes may be a liquid chromatography technique and a liquid flow detection technique or a multi-dimensional separation technique, for example, two dimensional liquid chromatography (LC x LC) or solvent extraction, such as liquid-liquid extraction or solid phase extraction, with a liquid chromatography technique (LLE or SPE-LC). Methods of using the device and separation and/or chromatographic methods using the device are also described.
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
G01N 1/00 - SamplingPreparing specimens for investigation
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
B01D 63/00 - Apparatus in general for separation processes using semi-permeable membranes
The invention relates to compounds of Formula (I) and methods for their preparation. Also described are pharmaceutical compositions comprising a compound of Formula (I) and their use in the treatment or prevention of conditions associated with mitochondrial dysfunction. Formula (I)
C07C 233/48 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
C07C 233/19 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
C07C 233/10 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
C07C 53/136 - Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings containing condensed ring systems
C07C 323/61 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
C07D 207/16 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
A61K 31/401 - ProlineDerivatives thereof, e.g. captopril
A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61K 31/223 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-amino acids
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61P 39/06 - Free radical scavengers or antioxidants
a) is supported in the housing. The at least one liquid take-up element and the at least one retention element are arranged whereby they are relatively movable into contact, and the at least one retention element is adapted on contact to in turn take-up the sample and retain the sample or a component thereof for in situ analysis or later recovery while protected within the housing. The liquid take-up element is preferably a capillary.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A system for the separation and detection of inorganic anions in a sample, the system comprising: • a separation channel with an inner coating of three or more alternating layers of a cationic polymer (e.g. hexadimethine bromide) and an anionic polymer (e.g. polystyrene sulfonate), wherein the first layer and the final layer are cationic polymer layers; • a detector for detecting inorganic anions that pass through a detection zone of the separation channel; • an injection system for injecting fluids including sample solutions and background electrolyte into an inlet end of the separation channel; wherein the background electrolyte comprises polyethyleneimine. Also described are corresponding methods, separation capillaries and cartridges for use in the system.
The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.
Provided herein is a method for automatically controlling inspired oxygen delivery, including: receiving signals representing a plurality of input oxygen saturation (SpO2) values for a patient; generating control values based on the input SpO2 values and a target SpO2 value; and generating output inspired oxygen concentration (FiO2) values based on the control values and reference inspired oxygen concentration (rFiO2) values; wherein the control values include: immediate control values, generated based on the input SpO2 values, the target SpO2 value, and an immediate gain coefficient; accumulation control values, generated based on the input SpO2 values, the target SpO2 value, and an accumulation gain coefficient; and predictive control values, generated based on the input SpO2 values, the target SpO2 value, and a predictive gain coefficient; wherein the immediate gain coefficient is determined based on the rFiO2 value; and wherein a non- linear compensation weighting is applied to the accumulation control value based on a predetermined non-linear relationship between partial pressure of arterial oxygen (PaO2) and SpO2.
A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
45.
A MICROFLUIDIC DEVICE AND METHODS FOR MANUFACTURING SAME
The present invention relates generally to a sample processing device, such as a microfluidic device, comprising a substrate, wherein the substrate comprises a plurality of channels configured to transport a fluid, and wherein the plurality of channels are substantially coated with lubricin, or a functional variant thereof. Also disclosed herein are methods of manufacturing such devices, methods of preventing fouling of a channel in a device using lubricin, or a functional variant thereof and methods of controlling the electrokinetic flow of an analyte through a channel that is substantially coated with lubricin, or a functional variant thereof. Also disclosed herein is chromatographic material for the electrophoretic and/or chromatographic separation of an analyte, wherein the chromatographic material is substantially coated with lubricin, or a functional variant thereof..
B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
B01D 15/08 - Selective adsorption, e.g. chromatography
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
A pen format liquid collection device includes an elongate generally tubular housing (12, 112, 212, 312) able to be held by hand and having an opening at one end, and at least one liquid take-up element (30, 130, 230, 330) mounted in the housing so as to be positioned or positionable to project at the opening, the at least one liquid take-up element then further postionable by hand manipulation of the housing to contact a volume of liquid to thereby take- up a sample of the liquid to be analysed. At least one retention element (230a, 330a) is supported in the housing. The at least one liquid take-up element and the at least one retention element are arranged whereby they are relatively movable into contact, and the at least one retention element is adapted on contact to in turn take-up the sample and retain the sample or a component thereof for in situ analysis or later recovery while protected within the housing. The liquid take-up element is preferably a capillary.
A device for extracting and concentrating a target analyte including a sample channel that receives the sample, a separation channel, a waste channel, a first junction between the sample channel and the separation channel, and, a second junction between the separation channel and the waste channel. The first junction selectively transports a first group of analytes, including target analytes, from the sample channel to the separation channel in accordance with a size of a first free transport region of the first junction. The second junction selectively transports a second group of analytes from the separation channel to the waste channel in accordance with a size of a second free transport region of the second junction, the second group being a subset of the first group, so as to concentrate a number of the target analytes in the separation channel.
Disclosed are methods and systems for the simultaneous separation and detection of analytes such as anions and cations in a sample using electrophoresis, the method comprising injecting the sample into an electrophoresis system comprising two separation channels through a single sample injection port which is in fluid communication with the two separation channels, separating analytes such as the cations in a first of the two separation channels and simultaneously separation analytes such as the anions in a second of the two separation channels, and detecting the analytes separated in each of the separation channels. Methods and systems are also disclosed that allow the separation and detection of analytes in a sample using electrophoresis in the presence of two or more different electrolytes concurrently, the method comprising providing an electrophoresis system comprising a single sample injection port in fluid communication with two or more separation channels, priming the separation channels with different background electrolytes, injecting the sample through the single sample injection port and into each of the separation channels, applying a voltage potential across each of the separation channels to effect a separation of the analytes in the respective channels during the flow of a different background electrolyte composition through each of the separation channels, and detecting the presence of the analytes in the sample.
The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.
The present invention generally relates to the use of porous polymer materials as a medium for the storage of biological samples. The present invention also relates to a method of drying and storage of biological samples on the porous polymer materials. The biological samples include blood and blood plasma samples.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
Disclosed are methods and systems for the simultaneous separation and detection of analytes such as anions and cations in a sample using electrophoresis, the method comprising injecting the sample into an electrophoresis system comprising two separation channels through a single sample injection port which is in fluid communication with the two separation channels, separating analytes such as the cations in a first of the two separation channels and simultaneously separation analytes such as the anions in a second of the two separation channels, and detecting the analytes separated in each of the separation channels. Methods and systems are also disclosed that allow the separation and detection of analytes in a sample using electrophoresis in the presence of two or more different electrolytes concurrently, the method comprising providing an electrophoresis system comprising a single sample injection port in fluid communication with two or more separation channels, priming the separation channels with different background electrolytes, injecting the sample through the single sample injection port and into each of the separation channels, applying a voltage potential across each of the separation channels to effect a separation of the analytes in the respective channels during the flow of a different background electrolyte composition through each of the separation channels, and detecting the presence of the analytes in the sample.
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
52.
"SYSTEM, APPARATUS AND METHOD FOR REDUCING TRAWL BYCATCH"
A system for reducing trawl bycatch, the system including at least one light arranged externally of the net to stimulate a phototactic response in the major bycatch species present to reduce entry of such species into the net.
A01M 29/10 - Scaring or repelling devices, e.g. bird-scaring apparatus using visual means, e.g. scarecrows, moving elements, specific shapes, patterns or the like using light sources, e.g. lasers or flashing lights
A01K 79/00 - Methods or means of catching fish in bulk not provided for in groups
53.
USE OF POROUS POLYMER MATERIALS FOR STORAGE OF BIOLOGICAL SAMPLES
The present invention generally relates to the use of porous polymer materials as a medium for the storage of biological samples. The present invention also relates to a method of drying and storage of biological samples on the porous polymer materials. The biological samples include blood and blood plasma samples.
The present invention generally relates to porous polymer monoliths. The present invention also relates to processes for the preparation of porous polymer monoliths, storage mediums formed from porous polymer monoliths and use thereof in the drying and storage of body fluids including blood and blood plasma samples.
C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
C08J 9/14 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
C08F 265/04 - Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group on to polymers of esters
C08L 33/06 - Homopolymers or copolymers of esters of esters containing only carbon, hydrogen, and oxygen, the oxygen atom being present only as part of the carboxyl radical
B01J 39/20 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
B01J 41/14 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
55.
POROUS POLYMER MONOLITHS, PROCESSES FOR PREPARATION AND USE THEREOF
The present invention generally relates to porous polymer monoliths. The present invention also relates to processes for the preparation of porous polymer monoliths, storage mediums formed from porous polymer monoliths and use thereof in the drying and storage of body fluids including blood and blood plasma samples.
C08J 9/26 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.
The invention is directed to a porous support for conducting one or more chemical reactions comprising a polymeric or silica porous monolith functionalised with an agent. In one embodiment, the agent is a catalytic or scavenging agent. The invention also relates to microreactors comprising such porous supports for use in conducting chemical reactions including organic chemical reactions, metal scavenging, diagnostic reactions or catalysis reactions. The novel porous supports described herein find particular application in small scale high throughput screening.
B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
B01J 19/02 - Apparatus characterised by being constructed of material selected for its chemically-resistant properties
B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
B01J 8/02 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (Australia)
UNIVERSITY OF TASMANIA (Australia)
Inventor
Miller, Matthew, Robert
Carter, Christopher, Guy
Nichols, Peter, David
Singh, Surinder, Pal
Zhou, Xue-Rong
Green, Allan, Graham
Abstract
The present invention relates to feedstuffs for use in aquaculture, as well as methods for producing said feedstuffs. The invention also provides methods for rearing fish and/or crustaceans. In particular, the present invention provides a method of rearing a fish or crustacean, the method comprising feeding the fish or crustacean a feedstuff comprising lipid, the fatty acid of said lipid comprising at least 5.5% (w/w) stearidonic acid (SDA).
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, including academic testing and assessment of applicants for entry to educational institutions; training and consultation services; information services related to education; testing services for selection of students for health professional courses.
60.
USE OF POROUS POLYMER MATERIALS FOR STORAGE OF BIOLOGICAL SAMPLES
The present invention relates to the use of a porous polymer material as a medium for drying and storage of a biological fluid sample, wherein the porous polymer material is a porous polymer monolith material, wherein the porous polymer monolith material is formed by a step-growth polymerisation process in which bi-functional or multifunctional monomers react to form polymer chains and cross-linked networks, wherein the porous polymer monolith material is associated with one or more support layer wherein the one or more support layer comprises a porous polymer matrix material selected from a polyether, polyester, polyamide, polycarbonate, polyurethane, polyanhydride, polythiophene, polyvinyl polymers, epoxy resins and a polyethylene selected from high-density polyethylene, polyethylene tetraphthalate, polyvinylidene fluoride (PVDF) and polytetrafluoroethylene (PTFE).
Provided herein is a method for automatically controlling inspired oxygen delivery, including: receiving signals representing a plurality of input oxygen saturation (SpO2) values for a patient; generating control values based on the input SpO2 values and a target SpO2 value; and generating output inspired oxygen concentration (FiO2) values based on the control values and reference inspired oxygen concentration (rFiO2) values; wherein the control values include: immediate control values, generated based on the input SpO2 values, the target SpO2 value, and an immediate gain coefficient; accumulation control values, generated based on the input SpO2 values, the target SpO2 value, and an accumulation gain coefficient; and predictive control values, generated based on the input SpO2 values, the target SpO2 value, and a predictive gain coefficient; wherein the immediate gain coefficient is determined based on the rFiO2 value; and wherein a non- linear compensation weighting is applied to the accumulation control value based on a predetermined non-linear relationship between partial pressure of arterial oxygen (PaO2) and SpO2.
A61B 5/083 - Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61M 16/12 - Preparation of respiratory gases or vapours by mixing different gases
62.
LIQUID-LIQUID MIXING DEVICE SUITABLE FOR SAMPLE PREPARATION BY LIQUID-LIQUID EXTRACTION
A liquid-liquid mixing device (10, 210) includes a barrel (20, 220) with a liquid port (23) at or adjacent one end. A plunger assembly (30) is reciprocably moveable along an axis in the barrel (20, 220) and includes a seal member (31, 231) and an agitator (50, 250). The seal member (31, 231) is in sealingly slidable engagement with the internal wall of the barrel (20, 220) to define a variable volume chamber (24, 224) therein in communication with the liquid port. The agitator (50, 250) is reciprocably moveable in the variable volume chamber (24, 224), which agitator (50, 250) includes one or more end to end passages (54) through which liquid in the chamber (24, 224) is forced as the agitator (250) reciprocates in the chamber (24, 224). The device (10) also includes a mode selector mechanism (60, 28, 46, 64, 65, 90, 92, 94, 96) for selection between at least two modes of operation for the plunger assembly, wherein the mode selector mechanism (60, 28, 46, 64, 65, 90, 92, 94, 96) is adjustable between two or more modes whereby movement of the plunger assembly (30) effects either movement of the agitator (50, 250) with the seal member (31, 231) or movement of the agitator (50, 250) relative to the seal member (31, 231), depending on the selected mode.
The present invention relates generally to porphyrin derivatives and their use in detecting poly- and perfluoroalkyl substances (PFAS). In particular, the present invention is directed to porphyrin derivatives having at least one receptor arm comprising an anion binding group substituted with a poly- or perfluorinated aliphatic group and their use as sensors for the detection of PFAS.
C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
A pen format liquid collection device includes an elongate generally tubular housing (12, 112, 212, 312) able to be held by hand and having an opening at one end, and at least one liquid take-up element (30, 130, 230, 330) mounted in the housing so as to be positioned or positionable to project at the opening, the at least one liquid take-up element then further postionable by hand manipulation of the housing to contact a volume of liquid to thereby take- up a sample of the liquid to be analysed. At least one retention element (230a, 330a) is supported in the housing. The at least one liquid take-up element and the at least one retention element are arranged whereby they are relatively movable into contact, and the at least one retention element is adapted on contact to in turn take-up the sample and retain the sample or a component thereof for in situ analysis or later recovery while protected within the housing. The liquid take-up element is preferably a capillary.
A system for the separation and detection of inorganic anions in a sample, the system comprising: • a separation channel with an inner coating of three or more alternating layers of a cationic polymer (e.g. hexadimethine bromide) and an anionic polymer (e.g. polystyrene sulfonate), wherein the first layer and the final layer are cationic polymer layers; • a detector for detecting inorganic anions that pass through a detection zone of the separation channel; • an injection system for injecting fluids including sample solutions and background electrolyte into an inlet end of the separation channel; wherein the background electrolyte comprises polyethyleneimine. Also described are corresponding methods, separation capillaries and cartridges for use in the system.
The invention relates to compounds of Formula (I) and methods for their preparation. Also described are pharmaceutical compositions comprising a compound of Formula (I) and their use in the treatment or prevention of conditions associated with mitochondrial dysfunction. Formula (I)
A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61K 31/223 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-amino acids
A61K 31/401 - ProlineDerivatives thereof, e.g. captopril
A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A61P 39/06 - Free radical scavengers or antioxidants
C07C 53/136 - Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings containing condensed ring systems
C07C 233/10 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
C07C 233/19 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
C07C 233/48 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
C07C 323/61 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
C07D 207/16 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
67.
PREPARATION FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE USING A WHOLE PLANT FIBRE EXTRACT FROM SUGARCANE
The invention relates to the field of food supplement manufacture and therapeutic manufacture. In particular, the invention relates to use of a prebiotic whole plant fibre extract from sugarcane in the diet of an individual for the prophylaxis and/or treatment of Inflammatory Bowel Disease. The invention also relates to a combination of the prebiotic whole plant fibre extract from sugarcane and probiotic strains, the synbiotic use of said combination in the diet of an individual, and the improved outcomes of the synbiotic approach in the prophylaxis and/or treatment of Inflammatory Bowel Disease.
The present invention generally relates to porous polymer monoliths. The present invention also relates to processes for the preparation of porous polymer monoliths, storage mediums formed from porous polymer monoliths and use thereof in the drying and storage of body fluids including blood and blood plasma samples.
C08F 279/06 - Vinyl aromatic monomers and methacrylates as the only monomers
C08J 9/26 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
C08L 33/10 - Homopolymers or copolymers of methacrylic acid esters
G01N 1/36 - Embedding or analogous mounting of samples
Disclosed are methods and systems for the simultaneous separation and detection of analytes such as anions and cations in a sample using electrophoresis, the method comprising injecting the sample into an electrophoresis system comprising two separation channels through a single sample injection port which is in fluid communication with the two separation channels, separating analytes such as the cations in a first of the two separation channels and simultaneously separation analytes such as the anions in a second of the two separation channels, and detecting the analytes separated in each of the separation channels. Methods and systems are also disclosed that allow the separation and detection of analytes in a sample using electrophoresis in the presence of two or more different electrolytes concurrently, the method comprising providing an electrophoresis system comprising a single sample injection port in fluid communication with two or more separation channels, priming the separation channels with different background electrolytes, injecting the sample through the single sample injection port and into each of the separation channels, applying a voltage potential across each of the separation channels to effect a separation of the analytes in the respective channels during the flow of a different background electrolyte composition through each of the separation channels, and detecting the presence of the analytes in the sample.
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
70.
PRECERAMIC RESINS AND POROUS POLYMER-DERIVED CERAMICS
The present disclosure relates to organosilicon preceramic resin compositions for forming porous polymer-derived ceramic materials. It also relates to porous organosilicon polymer-derived ceramic materials, and methods for forming porous organosilicon polymer-derived ceramic materials.
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
C04B 35/14 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on silica
C04B 35/571 - Fine ceramics obtained from polymer precursors
C04B 35/589 - Fine ceramics obtained from polymer precursors
C04B 38/08 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof by adding porous substances
C08G 77/20 - Polysiloxanes containing silicon bound to unsaturated aliphatic groups
C08G 77/24 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen halogen-containing groups
C08G 77/60 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon in which all the silicon atoms are connected by linkages other than oxygen atoms
C08L 83/06 - Polysiloxanes containing silicon bound to oxygen-containing groups
C08L 83/08 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen
C08L 83/16 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon onlyCompositions of derivatives of such polymers in which all the silicon atoms are connected by linkages other than oxygen atoms
The present disclosure relates to organosilicon preceramic resin compositions for forming polymer-derived ceramic materials, especially high-shrinkage polymer-derived ceramic materials. It also relates to organosilicon polymer-derived ceramic materials articles and methods for their formation.
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
C04B 35/571 - Fine ceramics obtained from polymer precursors
C08G 77/20 - Polysiloxanes containing silicon bound to unsaturated aliphatic groups
C08G 77/24 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen halogen-containing groups
C08L 83/06 - Polysiloxanes containing silicon bound to oxygen-containing groups
C08L 83/08 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen
72.
BACTERIAL COMPOSITIONS AND METHODS FOR PROMOTING PLANT GROWTH
