Abstract

Pharmaceutical compositions which either induce transient epithelial-mesenchymal transition (EMT) in epithelial cells, or inhibit fibroblast and immune cell migration, in the treatment of diseases or conditions associated with build-up of viscous extracellular fluids. Delivery vehicles include the use of mucus-penetrating nanoparticles

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07D 471/04 - Ortho-condensed systems
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

The present disclosure provides a method of preparing unsaturated hydrocarbons by black body photocatalytic (thermal radiative catalytic) conversion of saturated hydrocarbons. In this method, a saturated hydrocarbon reaction gas is introduced into a reaction furnace, and the saturated hydrocarbon is catalyzed to convert under heating and illumination conditions to prepare the unsaturated hydrocarbons. The photocatalysis is combined to the conventional thermal catalysis to improve the catalytic performance, accelerate the reaction speed, increase the conversion rate, and/or improve the selectivity of the catalytic reaction.

IPC Classes  ?

• C07C 5/32 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen

Abstract

A photodetector apparatus (100), being configured for detecting light in the visible or infrared spectrum, comprises a substrate (30), a waveguide (20), a detector section (10), a first contact section (50) and a second contact section (52). The substrate (30) has a substrate surface (32) and a cladding layer (40). The waveguide (20) is arranged above the substrate surface (32) in the cladding layer (40) and is adapted for guiding light. The detector section (10) comprises a p-doped region (12, 14) and an ndoped region (16, 18), and the detector section (10') is arranged for producing charge carriers by the (10) light guided in the waveguide (20). The first contact section (50) is connected to the p-doped region (12, 14) and the second contact section (52) is connected to the n-doped region (16, 18), the first and second contact sections (50, 52) being connectable to a measuring device for measuring an electrical signal based on the charge carriers produced by the light. The waveguide (20) and the detector section (10) are spaced apart by a portion of the cladding layer (40) with a mutual distance such that optical power of the light guided in the waveguide( 20) can be gradually transferred from the waveguide (20) to the detector section (10). Furthermore, a method of detecting light in the visible or infrared spectrum is described.

IPC Classes  ?

• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• H01L 31/105 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier being of the PIN type

Abstract

A beam-steering device (100) for spatial steering of a light beam comprises a waveguide array (10) being arranged on a substrate (50) and comprising a waveguide array input (12), multiple waveguides (14-1, 14-2, …, 14-i) and a waveguide array output (16), wherein the multiple waveguides (14-1, 14-2, …, 14-i) are adapted for simultaneously guiding light from the waveguide array input (12) to the waveguide array output (16) and for forming a light beam downstream of the waveguide array output (16) by superimposing the light guided by the waveguides (14-1, 14-2, …, 14-i), a phase shifter device (18) being arranged for applying controlled phase shifts to the light guided in each of the waveguides (14-1, 14-2, …, 14-i), and a grating array (22) including at least one patterned grating in optical communication with the waveguide array output (16), the grating array (22) being configured to radiate the light beam out of the beam-steering device (100) to a surrounding, wherein the waveguide array output (16) is arranged such that the light beam is formed downstream of the waveguide array output (16) with a main lobe and side lobes and with a beam angle Φ in a plane of the substrate (50), that is determined by the controlled phase shifts applied to the light by the phase shifter device (18) and a wavelength of the light, a slab propagation region (20) is arranged between the waveguide array output (16) and the grating array (22) such that the main lobe of the light beam is angularly relayed to the grating array (22) and the side lobes of the light beam leave lateral sides of the slab propagation region (20) before reaching the grating array (22), and the grating array (22) is arranged to radiate the light beam out of the beam-steering device (100) with a first angular direction with respect to the substrate (50), that is determined by the beam angle Φ. Furthermore, a method of beam-steering a light beam is described.

IPC Classes  ?

• G02F 1/295 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection in an optical waveguide structure
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02B 6/34 - Optical coupling means utilising prism or grating
• G01S 7/481 - Constructional features, e.g. arrangements of optical elements
• G01S 17/42 - Simultaneous measurement of distance and other coordinates

Abstract

Water soluble light harvesting multichromophores having a plurality of pendant chromophore groups are provided. Water soluble light harvesting multichromophores according to certain embodiments are polymers that include a polymeric backbone having norbornene repeat units, a pendant water solubilizing group component and a pendant chromophore component. Polymeric tandem dyes based on the subject multichromophores are also provided that further include an acceptor fluorophore linked to a norbornene repeat unit of the polymeric backbone and configured in energy-receiving proximity to at least one pendant donor chromophore group of the light harvesting multichromophore. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.

IPC Classes  ?

• C09B 69/10 - Polymeric dyesReaction products of dyes with monomers or with macromolecular compounds
• C09K 9/02 - Organic tenebrescent materials
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

A method comprising receiving data representing light intensity values corresponding to a flicker pattern of a reference light source powered by an alternating current (AC); operating a controllable illumination source, based, at least in part, on said data; capturing, using an imaging device, a sequence of images of a scene illuminated, at least in part, by said controllable illumination source; estimating an intensity value for at least one pixel in said array, correspondingly in each of said images in said sequence of images; and determining a temporal point in said flicker pattern of said reference light source, based, at least in part, on said estimating.

IPC Classes  ?

• H04N 5/235 - Circuitry for compensating for variation in the brightness of the object
• G03B 7/093 - Digital circuits for control of exposure time

Abstract

Systems and methods for imaging scenes illuminated by light sources that are powered by alternating current. Data concerning these light sources are extracted from the imagery. Systems comprising a rolling shutter imaging sensor and configured to de-flicker images with spatial flicker are also provided.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06K 9/46 - Extraction of features or characteristics of the image
• H04N 5/351 - Control of the SSIS depending on the scene, e.g. brightness or motion in the scene
• H04N 5/235 - Circuitry for compensating for variation in the brightness of the object

Abstract

The invention provides novel synthetic antibodies directed against VEGF and uses thereof.

IPC Classes  ?

• A61K 38/18 - Growth factorsGrowth regulators
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• C07K 16/22 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors

Abstract

Computer implemented method for rendering an image of a three-dimensional scene on an image plane by encoding at least a luminosity in the image plane by a luminosity function. The value of the luminosity can be computed at substantially each point of the image plane by using a set of stored input data describing the scene. The method includes constructing the luminosity function as equivalent to a first linear combination involving the functions of a first set of functions, and computing at least the value of the coefficients of the first linear combination, by solving a first linear system, obtained by using at least the functions of the first linear combination, at least a subset of the first subset of the image plane, and the luminosity at the points of said subset. The method further includes storing the value of the coefficients of the first linear combination and at least the information needed to associate each coefficient to the function multiplying said coefficient in the first linear combination. The first set of functions comprises each function of a second set of functions satisfying a selection condition, which depends at least on the set of stored input data. Moreover, the points of the first subset are distributed according to a first distribution criterion, which depends on the location of the support of at least a function of the first set of functions.

IPC Classes  ?

• G06T 15/50 - Lighting effects
• A63F 13/52 - Controlling the output signals based on the game progress involving aspects of the displayed game scene

Abstract

The present invention provides methods of identifying the presence and relative abundance of a protein in or on a cell or population of cells, with the methods comprising applying to a population of cellular proteins a collection of Fab-phage particles that contain nucleic acid encoding at least one antibody Fab fragment, wherein each of the antibody Fab fragments has a known protein to which it will bind in a specific manner. After binding is allowed to occur, those Fab-phage not bound to targets are washed away and the remaining phage are propagated in bacteria before the nucleic acid within the Fab-phage is amplified and then sequenced to determine the polynucleotide sequences of the nucleic acid molecules from the Fab-phages that bound to the cellular proteins. The nucleotide sequences of the nucleic acid molecules from the Fab-phages correlate to the coding sequences of the antibody Fab fragments that are known to bind in a specific manner to a protein.

IPC Classes  ?

• C40B 40/02 - Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cellsLibraries contained in or displayed by vectors, e.g. plasmidsLibraries containing only microorganisms or vectors
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
• C07K 19/00 - Hybrid peptides
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

Methods and systems for processing fluids utilizing a digital microfluidic device and transferring droplets from the digital microfluidic device to a downstream analyzer are described herein. Methods and systems in accordance with the present teachings can allow for the withdrawal of fluid from a digital microfluidic device, and can in some aspects enable the integration of a digital microfluidic device as a direct, in-line sample processing platform from which a droplet can be transferred to a downstream analyzer.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B01F 13/00 - Other mixers; Mixing plant, including combinations of dissimilar mixers
• G01N 27/447 - Systems using electrophoresis
• G01N 30/16 - Injection
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor

Abstract

A novel isolated protein, referred to herein as “caltubin”, is provided. Caltubin promotes axonal regeneration, and prevents or at least reduces axonal retraction in neurons.

IPC Classes  ?

• A01N 37/18 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N, e.g. carboxylic acid amides or imidesThio-analogues thereof
• A01N 57/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
• A61K 38/00 - Medicinal preparations containing peptides
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

Abstract

7 is provided, as well as a biomaterial comprising the peptide for use to treat conditions resulting from cell death or apoptosis.

IPC Classes  ?

• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
• C07K 5/11 - Tetrapeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
• C07K 14/515 - Angiogenic factorAngiogenin
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

Provided herein is a method of treating Respiratory Syncytial Virus (RSV) infection in a cell. The method involves administering the guanosine-rich oligonucleotide (GRO) AS 1411 (5'- GGTGGTGGTGG TTGTGGTGGTGGTGG-3' - also known as GR026B and AGRO100) to the cell.

IPC Classes  ?

• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61P 31/14 - Antivirals for RNA viruses

Abstract

Provided herein are antibodies or fragments thereof that specifically bind an interferon-interferon receptor ternary complex. Also provided herein are antibodies or fragments thereof that specifically bind one or two type I interferons. Also provided herein are methods of treating or preventing an autoimmune disease, viral infection, or cancer in a subject comprising administering an effective amount of any of the antibodies described herein to the subject.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 31/12 - Antivirals

Abstract

A novel isolated protein, referred to herein as "caltubin", is provided. Caltubin promotes axonal regeneration, and prevents or at least reduces axonal retraction in neurons.

IPC Classes  ?

• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 25/00 - Drugs for disorders of the nervous system
• C12N 15/12 - Genes encoding animal proteins

Abstract

Means are provided of increasing the growth potential and abiotic stress resistance in plants, characterized by expression of polynucleotides stably integrated into a plant genome or stably incorporated in the plant. Further provided are isolated nucleic acids and their stable inclusion in transgenic plants. The transgenic plants have shown desirable phenotypic characteristics when compared to control plants, for example, improved drought-resistance. Also taught are plants having increased growth potential due to improved abiotic stress resistance.

IPC Classes  ?

• C12N 15/53 - Oxidoreductases (1)
• A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy
• C07K 14/415 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from plants
• C12N 15/29 - Genes encoding plant proteins, e.g. thaumatin
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase

Abstract

A peptide comprising the amino acid sequence, X1X2RX3DX4X5 X6 X7 is provided, as well as a biomaterial comprising the peptide for use to treat conditions resulting from cell death or apoptosis.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 38/07 - Tetrapeptides
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C07K 17/02 - Peptides being immobilised on, or in, an organic carrier
• C12N 11/02 - Enzymes or microbial cells immobilised on or in an organic carrier
• C12N 5/07 - Animal cells or tissues

Abstract

Provided herein is a method of treating Respiratory Syncytial Virus (RSV) infection in a cell. The method involves administering a nucleolin peptide, a nucleotide antibody, or a nucleolin RNAi to the cell.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 31/12 - Antivirals
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage

Abstract

There is provided an output coupler modulated laser. The laser includes an optical resonator for light to circulate within, a gain medium housed within the optical resonator and a pump. An output coupler included in the optical resonator is responsive to a control signal to generate a modulated optical signal at a laser output port, and a complementary signal at a through port to retain circulating light within the optical resonator. The output coupler and the pump are jointly controllable to maintain the power level of the circulating light substantially at a selected, steady state level, and to decouple the modulation response of the laser from the intrinsic response of the circulating light due to interaction with the gain medium. The output coupler is configurable for simple amplitude modulation, Phase-Shift Keying (PSK), Quadrature Amplitude Modulation (QAM), and is suitable for use with high- finesse, micron or millimeter scale resonators.

IPC Classes  ?

• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
• H04B 10/50 - Transmitters
• H04L 27/34 - Amplitude- and phase-modulated carrier systems, e.g. quadrature-amplitude modulated carrier systems

Abstract

A system and method for micromanipulating samples are described to perform automatic, reliable, and high-throughput sample microinjection of foreign genetic materials, proteins, and other molecules, as well as drawing genetic materials, proteins, and other molecules from the sample. The system and method overcome the problems inherent in traditional manual micromanipulation that is characterized by poor reproducibility, human fatigue, and low throughput. The present invention is particularly suited for adherent cell microinjection but can be readily extended to aspiration, isolation, and electrophysiological measurements of microorganisms, unicellular organisms, or cells.

IPC Classes  ?

• C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors

Abstract

A method of making an aqueous solution of a bio-adhesive, supramacromoIecular nitric oxide generatable polymer complex of the general formula (I): wherein R1 is independently selected from the group consisting of an alkane unsubstituted or substituted with alkoxy groups; R2 is independently selected from the group consisting of C 1-6 alkyl; R3 and R4 are independently selected from the group consisting of optionally substituted aliphatic or aromatic alkyl; W is a hydrogen-bond accepting ftractional group-containing entity; Y is a carboxylic acid ester or amide linkage; R is independently selected peptide linking group; T1, T2, T3 and T4 are independently selected polymer residues; and m1, m2, m3, n1, and n2 are integers greater than 25; and wherein P has a molecular weight of about 1 x 103 to 1 x 107 and Q has a molecular weight of about 1 x 103to 1 x 107; the method comprising (a) covalently linking a S-nitrosothiol compound having an amino linking group with a bio-adhesive, hydrophobic polyanhydride compound to form a nitric oxide donor polymeric conjugate carrier; comprising (i) treating the polyanhydride compound dissolved in an aprotic solvent with an aqueous solution of said S-nitrosothiol compound for an effective period of time and protected from light; (ii) removing the aprotic solvent to produce an essentially aqueous solution of the conjugate carrier; and (b) mixing the solution of the conjugate carrier with an intermolecular hydrogen bond acceptable polymer to produce an aqueous solution of the complex. Solutions are to be used in the treatment of healing wounds. Also provided is the polymeric conjugate carrier for use in the treatment of healing wounds through the release of nitric oxide. The invention is also of value through use of photo irradiation of the conjugate carrier and complex containing systems, to enhance the healing of skin wounds.

IPC Classes  ?

• C09J 139/06 - Homopolymers or copolymers of N-vinyl-pyrrolidones
• A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
• A61L 15/44 - Medicaments
• A61L 15/58 - Adhesives
• A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• C08L 35/02 - Homopolymers or copolymers of esters
• C08L 39/06 - Homopolymers or copolymers of N-vinyl-pyrrolidones
• C09J 135/02 - Homopolymers or copolymers of esters
• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates

Abstract

An ultrasonic measurement system comprises a processor configured for enhancing a received ultrasonic signal, where the received ultrasonic signal is a frequency domain signal. The enhancing involves deconvolving the received ultrasonic signal to yield a filtered signal, determining autoregressive extrapolation parameters based on frequency amplitude fluctuations of the filtered signal within a frequency range over which a corresponding reference signal has a high signal-to-noise ratio, and carrying out an autoregressive spectral extrapolation of the filtered signal using the autoregressive extrapolation parameters to yield an enhanced ultrasonic signal.

IPC Classes  ?

• G01N 29/46 - Processing the detected response signal by spectral analysis, e.g. Fourier analysis
• G01H 17/00 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves, not provided for in the other groups of this subclass
• G01N 29/50 - Processing the detected response signal using auto-correlation techniques or cross-correlation techniques
• G01S 7/527 - Extracting wanted echo signals
• G06F 17/14 - Fourier, Walsh or analogous domain transformations
• G06F 17/17 - Function evaluation by approximation methods, e.g. interpolation or extrapolation, smoothing or least mean square method

Abstract

The input device (1) comprises a touch-sensitive surface (10a) forming at least one isotonic input area and elastic abutment means (11) forming at least one passive elastic input area that is adjacent to the isotonic input area. A position control is performed in the isotonic input area and a rate control is performed in the elastic area.

IPC Classes  ?

• G06F 3/041 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means

Abstract

The present invention details the design and operation of a miniaturized device array in which a range of simultaneous mechanical forces are produced by a single external pressure source. The invention is primarily embodied in a microfabricated device arrays designed to rapidly probe biological cell response to various combinations of mechanical, chemical and extra-cellular matrix parameters in a high-throughput fashion.

IPC Classes  ?

• F15B 5/00 - Transducers converting variations of physical quantities, e.g. expressed by variations in positions of members, into fluid-pressure variations or vice versaVarying fluid pressure as a function of variations of a plurality of fluid pressures or variations of other quantities
• B81B 3/00 - Devices comprising flexible or deformable elements, e.g. comprising elastic tongues or membranes
• B81B 7/04 - Networks or arrays of similar microstructural devices
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• C40B 30/06 - Methods of screening libraries by measuring effects on living organisms, tissues or cells
• C40B 30/10 - Methods of screening libraries by measuring physical properties, e.g. mass
• G01N 19/00 - Investigating materials by mechanical methods

Abstract

A bio-adhesive supramacromolecular complex of the general formula (1): wherein R1 is an alkane unsubstituted or substituted with alkoxy groups; R2 is a lower alkane; R3 and R4 are long chain, optionally substituted, alkanes; W is a hydrogen-bond accepting functional group-containing entity; Y is a carboxylic acid ester or amide; Z is a linking group; T1, T2, T3 and T4 are terminal groups; and m1, m2, n1 and n2 are integers selected from at least 25; and wherein P has a molecular weight of about 1 x 103 to 1 x 107 and Q has a molecular weight of about 1 x 103 to 1 x 107. The complex provides controlled nitric oxide release over a longer period of time than prior art compounds in the locally delivery systems. Novel compositions, methods of preparation, apparatus including layer-by-layer assemblies coating, electrospinning and ultrasonic atomization, skin coverings containing and medical use of the complexes are described.

IPC Classes  ?

• C09J 139/06 - Homopolymers or copolymers of N-vinyl-pyrrolidones
• A61K 31/785 - Polymers containing nitrogen
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/70 - Web, sheet or filament bases
• A61L 15/26 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bondsDerivatives thereof
• A61L 15/58 - Adhesives
• A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials
• A61L 29/08 - Materials for coatings
• A61L 31/10 - Macromolecular materials
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• C09J 11/06 - Non-macromolecular additives organic
• C09J 135/02 - Homopolymers or copolymers of esters

IPC Classes  ?

• G06Q 10/00 - AdministrationManagement

Abstract

Systems and methods for integrating maps in which roads are represented as polylines. The main novelty of the invention is in using only the locations of the endpoints of the polylines rather than trying to match whole lines. Experiments on real-world data are given, showing that this approach of integration based on matching merely endpoints is efficient and accurate (that is, it provides high recall and precision).

IPC Classes  ?

• G06F 7/00 - Methods or arrangements for processing data by operating upon the order or content of the data handled

Abstract

Aptamers against the glycosylated form of MUC1 are described, along with their use in treatment and diagnosis of conditions associated with elevated production of MUC1.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• A61K 31/70 - CarbohydratesSugarsDerivatives thereof

Abstract

A sensing device includes a sensor, a control unit, an input/output (I/O) interface, and a non-volatile magnetic memory device having one or more memory cells, each of the memory cells, wherein each memory cell of the non- volatile magnetic memory device includes a magnetic switch including a magnetic component and a write coil located proximate the magnetic component, the write coil coupled to receive a current sufficient to create a remnant magnetic polarity in the magnetic component, and a Hall sensor, positioned proximate the magnetic component, to detect the remnant magnetic polarity indicative of a stored data bit.

IPC Classes  ?

• G11C 11/14 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using thin-film elements
• G11C 11/02 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements
• G11C 11/18 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using Hall-effect devices
• G11C 7/10 - Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers

Abstract

A non-volatile magnetic memory device having one or more memory cells, each of the memory cells includes a magnetic switch including a magnetic component and a write coil located proximate the magnetic component, the write coil coupled to receive a current sufficient to create a remnant magnetic polarity in the magnetic component, and a Hall sensor, positioned proximate the magnetic component, to detect the remnant magnetic polarity indicative of a stored data bit.

IPC Classes  ?

• G11C 11/02 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements
• G11C 17/02 - Read-only memories programmable only onceSemi-permanent stores, e.g. manually-replaceable information cards using magnetic or inductive elements