Provided are improved methods for Vitamin K, including but not necessarily limited to MK-7 production through bacterial fermentation using biofilm reactors. Fed-batch addition of carbon sources, such as glucose, are used as the base media in biofilm reactors. Fed-batch strategies are shown to be significantly effective in glucose-based medium, increasing the end-product concentrations to more than 2-fold higher than the level produced in suspended-cell bioreactors.
Provided are improved methods for Vitamin K, including but not necessarily limited to MK-7 production through bacterial fermentation using biofilm reactors. Fed-batch addition of carbon sources, such as glucose, are used as the base media in biofilm reactors. Fed-batch strategies are shown to be significantly effective in glucose-based medium, increasing the end-product concentrations to more than 2-fold higher than the level produced in suspended-cell bioreactors.
A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
C07C 50/14 - Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
In one aspect the invention provides an electrical inverter assembly arranged to connect to a direct current electrical supply and configured to supply alternating current to at least one electrical load. This inverter assembly includes at least one pair of inverters, being a primary inverter and a secondary inverter, where each inverter has a set of input terminals and output terminals. The invention also includes at least two banks of energy storage capacitors provided in association with each pair of primary and secondary inverters, and a capacitor switching structure associated with each pair of inverters. This capacitor switching structure is arranged to cyclically connect a discharged energy storage capacitor bank in series with the input terminals of the primary inverter and the direct current electrical supply to charge the capacitor bank, and to concurrently connect a charged energy storage capacitor bank with the input terminals of the secondary inverter to discharge the capacitor bank.
H02M 7/00 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output
H02M 7/483 - Converters with outputs that each can have more than two voltage levels
H02M 7/537 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters
H02M 3/18 - Conversion of DC power input into DC power output without intermediate conversion into AC by dynamic converters using capacitors or batteries which are alternately charged and discharged, e.g. charged in parallel and discharged in series
H02M 9/04 - Conversion of DC or AC input power into surge output power with DC input power using capacitative stores
4.
A SURGICAL IMPLANT CONDUCTOR WITH INCREASED RADIO FREQUENCY ALTERNATING CURRENT RESISTANCE
In one aspect the invention provides a surgical implant conductor formed from a length of conductive material which exhibits increased radio frequency alternating current resistance. This conductive material defines an exterior surface where at least a portion of the exterior surface of the conductor defines a region with a roughened surface. Preferably the roughening of the exterior surface increases the area of the exterior surface when compared to a non-roughened surface, resulting in a reduction in the effective cross-section area of the conductor used to transport alternating currents.
In one aspect the invention provides a time of flight camera system which includes a time of flight transmitter arranged to transmit modulated radiation at a target, and a phase adjustment element configured to adjust the phase of a source modulation signal used to modulate the radiation transmitted at the target. This phase adjustment element provides a set of phase separated output signals, each output signal provided having one of a set phase offsets values applied, where at least one of these phase offset values is the cancellation phase value of another member of the set of phase offset values. The camera system also includes an image sensor modulated with the source modulation signal and configured to measure radiation reflected from a target, and a processor arranged to receive the image sensor measurements and being programmed to resolve range information from the measurements received by the image sensor.
The invention provides a time of flight camera system arranged to resolve the direct path component or the multi-path component of modulated radiation reflected from a target. The camera system includes a time of flight transmitter arranged to transmit modulated radiation at a target, and at least one pattern application structure operating between the transmitter and the target. The pattern application structure operates to apply at least one structured light pattern to the modulated transmitter radiation. The camera system also includes an image sensor configured to measure radiation reflected from a target. The camera system is arranged to resolve from the measurements received the contribution of direct source reflection radiation reflected from the target.
In one aspect the invention provides a fluid temperature modification apparatus which includes at least one temperature modification element associated with a fluid conduit. This temperature modification element or elements are located adjacent to an outlet of the fluid conduit. The apparatus also includes at least one energy storage capacitor, and at least one trigger switch which when operated connects one or more energy storage capacitors to a temperature modification element. The operation of a trigger switch at least partially discharges at least one energy storage capacitor to energise a temperature modification element which modifies the temperature of fluid in the conduit adjacent to the outlet port of the conduit.
F24H 9/20 - Arrangement or mounting of control or safety devices
F24H 1/10 - Continuous-flow heaters, i.e. heaters in which heat is generated only while the water is flowing, e.g. with direct contact of the water with the heating medium
8.
RESONANT MODULATION FOR LOW POWER RANGE IMAGING CAMERAS
An amplitude modulated continuous wave range imaging device has a signaling device configured to emit an intensity modulated illumination signal. An image sensor is configured to capture a plurality of images of a reflection of the modulated illumination signal. The captured images include intensity and/or phase components for a plurality of pixels of the image sensor. Each pixel includes a first modulation terminal having a first capacitive component. A first driver is configured to charge a first set of modulation terminals of the plurality of pixels. A second driver is configured to charge a second set of modulation terminals of the plurality of pixels. A charge transfer circuit is connected between the first set of modulation terminals and the second set of modulation terminals. The charge transfer circuit is configured to transfer charge between the first set of modulation terminals and the second set of modulation terminals.
G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging
G01S 17/32 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated
G01S 17/36 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated with phase comparison between the received signal and the contemporaneously transmitted signal
9.
DIGITAL CONTROL FOR CONTROLLING AND LINEARIZING AN AC IMPEDANCE
An apparatus for regulating AC power of a power source in a power circuit is provided. The apparatus includes a full-wave bridge rectifier, a power transistor array, and a controller. The full-wave bridge rectifier is configured to receive an AC input from the power source. The power transistor array is connected to the full-wave bridge rectifier. The power transistor array is configured to receive the AC input from the full-wave bridge rectifier and to generate an AC signal. The power transistor array may include only a single transistor or a plurality of transistors connected in series, for example. The controller is connected to the power transistor array. The controller is configured to receive the AC signal from the power transistor array, or the output of the AC regulator in some embodiments, and to determine a correction output to send to the power transistor array to control an AC impedance of the power circuit to generate an AC output.
H02M 7/217 - Conversion of AC power input into DC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
10.
VIBRATION SENSOR ASSEMBLY WITH AMBIENT NOISE DETECTION
A sensor assembly for detecting vibrational energy on a target surface, including at least one target vibration transducer configured to measure vibrational energy associated with at least one target surface; and at least one environmental vibration transducer, each environmental vibration transducer being configured to measure vibrational energy in the immediate vicinity of the environmental vibration transducer wherein the environmental vibration transducer is vibrationally isolated from the target vibration transducer.
A bone matrix, including: a bone matrix material, which has had organic material removed, and a replacement material that has replaced the organic material, the bone matrix characterised in that the bone matrix is formed from a single piece of bone.
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
This invention relates to a method for purifying metal alloy and intermetallic powders. Particularly, the present invention relates to a method for the reduction or elimination of the content of the dissolved oxygen and to remove the metal oxide inclusions from metal alloy and intermetallic powders including the steps of: a) placing the metal in powder form into a reaction apparatus; b) introducing a suitable carrier substance to the metal powder; and c) introducing calcium vapour into the reaction apparatus to create a reaction between the metallic powder and calcium vapour thereby removing inclusions in the metal as shown in Figure 11.
C22B 9/10 - General processes of refining or remelting of metalsApparatus for electroslag or arc remelting of metals with refining or fluxing agentsUse of materials therefor
This invention relates to a method for producing alloy and intermetallic powders. Particularly to a method for the production of titanium based alloy and intermetallic powders. A first metal and a second metal oxide powder are mixed with a controlled metal/metal oxide molar ratio. This mixture is heated, becomes self propagating and leads to formation of a mixture of alloy liquid and oxide solid. Pressure is applied to separate the phases and upon cooling produces a metallic solid. Figure 1a shows an example of a solid crushed into a powder as produced by this method.
An object location indication apparatus which includes a position determination system adapted to determine the position of the apparatus a plurality of audio channels, each connected to an audio output device wherein each channel is associated with a direction, an audio signal supply element adapted to supply an audio component signal to each channel, said plurality of audio component signals in combination providing a substantially continuous composite audio signal, wherein the audio signal supply element modulates each audio component signal depending on the direction of travel required to reach the object from the position determined for the apparatus.
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