An oral lozenge. The oral lozenge comprises from 0.02 to 0.5% w/w chlorhexidine or a salt thereof and from 2 to 80% w/w polyol. The polyol comprises xylitol, erythritol or maltitol.
An apparatus (800), computer program (808) and method for performing execution of a computational neural layer comprising interconnected neural processing cells each comprising: a receptive field generator (‘S’, 104) configured to generate a receptive field (St) based on inputs (x1t-xNt) to which synaptic weights (W1x-WNx) are applied; a transfer function (‘A’, 106) configured to generate a field variable (At); and an activation circuit (‘Y’, 108) configured to generate an output (Yt) for controlling an activation level of the neural processing cell, based at least in part on the field variable, wherein the transfer function is dependent on: the receptive field; a local contextual field (Ct) dependent on a plurality of receptive fields (S2t-SNt) of the other ones of the neural processing cells (102B, . . . ) of the computational neural layer; and a universal contextual field (Mt-1) indicative of a cross-cell memory state, based at least in part on previous output values of the neural processing cells.
The invention provides a non-orally administered composition comprising disulfiram or a derivative thereof for use in preventing or treating a viral infection in a subject or ameliorating the symptoms thereof. The invention further provides a method of treating viral infection in a subject or ameliorating the symptoms thereof, the method comprising administering a non-orally administered composition comprising disulfiram or a derivative thereof to the subject.
A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
41 - Education, entertainment, sporting and cultural services
Goods & Services
Education, teaching, instruction and tuition services;
university education services; academic and vocational
education services; university services, namely, education,
teaching, instruction and tuition services; arranging and
conducting conferences, congresses, seminars, symposiums,
and workshops; provision of courses of instruction, lectures
and seminars all relating to academic or vocational
subjects; arranging and conducting educational examinations;
conferral of degrees and diploma certificates; production of
video tapes, CDs, CD-ROMs and programmes relating to
training, instruction and information; provision of
electronic publications (not downloadable); publication of
electronic books, magazines, newspapers, journals,
periodicals, and other publications on-line; digital imaging
services [editing of images]; education services relating to
photographic printing; publication of printed matter, books,
texts, journals, magazines, periodicals and other
publications; provision of correspondence courses; provision
of on-line training; provision and operation of on-line
learning platforms; organising and arranging of training
courses, conferences, competitions and seminars for
education or entertainment; business training, technological
training and vocational training; day release courses;
evening courses; provision of recreation and sporting
activities and facilities; library services; sports and
physical education instruction services; organisation of
balls, education and sports competitions; teaching services
related to development of teaching and assessment methods;
provision of training facilities; rental of stadium
facilities; concert and theatre services; music, orchestral
music, concert, disco and live performances; museum and art
gallery services; provision of facilities for sporting
events; research and consultancy services, all relating to
education and training; arranging and conducting
competitions; entertainment and educational services,
namely, providing information, directories in the fields of
entertainment, news, current events, history, sports, games,
the media, cultural, social and family events and
activities, hobbies, publications; entertainment and
educational services, namely, provision of information in
the fields of entertainment, news, current events, history,
sports, games, the media, cultural, social and family events
and activities, hobbies, publications online from a computer
database or via the internet; entertainment and educational
services, namely, live performances, sporting events,
cultural, social and family events, and lectures; publishing
services; publication of electronic journals and web logs,
featuring user generated or specified content; providing
information related to news, cultural, social and family
events and academic matters from searchable indexes and
databases of information, including text, electronic
documents, databases, graphics and audio visual information,
on computer and communication networks; provision of
electronic publications, not downloadable; provision of
non-downloadable publications; production and rental of
educational and instructional material; editing written
texts; providing information regarding cultural matters from
searchable indexes and databases of information, including
text, electronic documents, databases, graphics and audio
visual information, on computer and communication networks;
arranging, conducting and organisation of events for
academic, social, political, charitable or sporting
purposes; provision of electronic publications; production
of radio and television programmes; research and development
relating to academic subjects and vocational skills;
consultancy, information and advisory services relating to
all the aforesaid services.
A system, method and apparatus for using a distributed ledger to control searching for information stored in a distributed storage system. The system comprises at least one apparatus, the system comprising: identifier storing means for causing, at least in part, an identifier to be stored in the distributed ledger, the identifier enabling a determination of where at least a portion of the information is stored in the distributed storage system in dependence on finding the identifier in the distributed ledger.
H04L 9/06 - Arrangements for secret or secure communicationsNetwork security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
A computer implemented method for automatic print analysis, the method comprising: receiving a first image wherein the first image shows one or more of: a latent print, a patent print, an impressed print, and an actual finger, palm, toe and/or foot; and wherein the first image includes characteristic features of at least one of a finger, a palm, a toe and a foot; creating an orientation field by estimating the orientation of one or more features in the first image, wherein the estimating comprises: applying an orientation operator to the first image, the orientation operator being based on a plurality of isotropic filters lying in quadrature.
The present invention provides a method for treating pleuroperitoneal membrane cancers, and comprises: delivering disulfiram or a derivative thereof that is effective in amount in the treatment, into the pleura and/or the peritoneum of a test person that needs to be treated. The present invention also provides a pharmaceutical component comprising the disulfiram or the derivative thereof, and a reagent kit.
A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
The invention relates to a probiotic microorganism at least partially coated with a poly glutamic acid, for example poly-γ-glutamic acid (γ-PGA). The invention also relates to an ingestible product comprising the probiotic microorganism at least partially coated with a poly glutamicacid and a method of making aprobiotic microorganism at least partially coated with a poly glutamic acid. The invention also relates to a method of making poly-γ-glutamic acid (γ-PGA).
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
C12N 1/04 - Preserving or maintaining viable microorganisms
The invention relates to the use of di-aspirin (bis(2-carboxyphenyl)succinate) and its derivatives in the treatment of colon and colorectal cancer. It also relates to novel derivatives of di-aspirin and to a method of synthesis of the di-aspirin and its derivatives.
A61K 31/616 - Salicylic acidDerivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
A61K 31/621 - Salicylic acidDerivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
C07C 69/24 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with monohydroxylic compounds
C07C 69/96 - Esters of carbonic or haloformic acids
C07C 205/43 - Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
C07C 235/60 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho- position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 235/88 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups further acylated
A disulfiram formulation comprising disulfiram or a derivative thereof together with a component that increases the in vivo half life of the disulfiram or the derivative thereof, and uses thereof. In particular for use with or without a separate copper formulation for the treatment of cancer.
A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
The invention relates to the use of di-aspirin (bis(2-carboxyphenyl)succinate) and its derivatives in the treatment of colon and colorectal cancer. It also relates to novel derivatives of di-aspirin and to a method of synthesis of the di-aspirin and its derivatives.
A61K 31/616 - Salicylic acidDerivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
A61K 31/621 - Salicylic acidDerivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
C07C 69/86 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
C07C 69/96 - Esters of carbonic or haloformic acids
C07C 203/04 - Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
C07C 205/43 - Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
C07C 235/60 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho- position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
A heating apparatus (100) arranged, in use, to accommodate an electrically conductive work-piece (300) comprising two or more parts (302,304) of which at least one part is a sheet of conductive material (302) of up to 3mm thick, and the apparatus comprising at least one coil (102) having a first face (106) arranged, in use, to be adjacent, the electrically conductive work-piece (300) of which the part adjacent the first face is a sheet (302) of conductive material of up to 3mm thickness, and a second face (108) on an opposite side of the coil (102) from the first face (106), and the apparatus (100) also comprising a flux- intensifier (110) which is provided adjacent the second face (108) and the radial outer face (112) and a temperature sensor (410) arranged to measure the temperature of the work- piece (300) wherein, in use, the coil (102) is arranged to have electric current passed therethrough and the coil (102) and flux-intensifier (110) are arranged to concentrate the resultant magnetic flux in a localised surface region of roughly between 0.1mm and 0mm diameter of the electrically conductive work-piece (300) in order to heat the two or more parts of the work-piece in the localised region to a substantially uniform temperature suitable for diffusion bonding across the localised region (307) of the two or more parts of the work-piece (300) in a time between roughly a few milliseconds and roughly 5 minutes and wherein the apparatus is arranged to control the temperature according to the temperature sensor (410)
A rotating device (1) arranged to rotate about an axis and having a body portion (2) containing a cavity (20), the body portion (2) having an upper surface (10) having a substantially circular access hole (12) therethrough generally of a first radius from the axis and providing access to the cavity (20), and at least one drive surface arranged to have force applied thereto to rotate the device (1) and being provided in the cavity (20) at least a second radius from the axis wherein the second radius is greater than the first.
The invention relates to a nucleic acid molecule which comprises a cancer cell specific promoter and an enhancer element which comprises more than one NF-ϰB binding site, to a rector comprising said nucleic acid, to a pharmaceutical composition comprising said vector and to a method of treating cancer comprising administration of said vector.
The invention relates to a shoe, and in particular but not exclusively a dance or performing arts shoe, comprising a separate shank portion (2) which engages with a separate toe box portion (3) to form a unitary part. The invention also relates to methods of construction of said shoe.
The present invention relates to a probe adapted for use in retrieving blood clots from part of the blood circulatory system, together with an associated device and method. The probe has a first end and a second end and each end is provided with an aperture therein. The aperture in the second end is adapted in use to be connected to a suction pump by a connection means. A channel is provided passing from the aperture in the second end of the probe to the aperture in the first end of the probe. The probe has no moving parts and is of a suitable configuration to give rise, in use, to the creation of a sheer force in the form of a vortex around the first end of the probe.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
The invention relates to an equine training aid for enabling a horse, pony, donkey or the like, particularly dressage or show horses, to adopt an optimum outline or profile which comprises a self -centring, continuous loop portion (1) , configured, during lungeing or riding, to be in contact tension with the equine wherein the continuous loop portion (1) comprises a front section (Ia) and a rear section (Ib) each of which are linked by linking means in the form of rings (2a) and pivotal clips (2b) . Each of the loop sections (Ia) and (Ib) additionally has two adjustment means (e.g. sliders; (3)) to allow each loop section to be lengthened or shortened and both ends of the rear section (Ib) terminate in a safety loop (4) which allows rotation of the device to a limited extent and prevents the rear section of the loop portion (Ib) from slipping down the hind legs of the equine when the device is being dismantled and removed from the equine.
