Goods & Services

Pharmaceutical and veterinary preparations for the treatment of diseases or conditions of the respiratory system; pharmaceutical and veterinary preparations for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; pharmaceutical and veterinary preparations for the alleviation or prevention of pain or inflammation; inhalers filled with powders for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; pharmaceutical preparations, namely, powders for asthma inhalers; pharmaceutical preparations, namely, powders for transdermal injection for the alleviation or prevention of pain, for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; pharmaceutical and veterinary preparations for oral ingestion for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; pharmaceutical and veterinary preparations for topical administration for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; pharmaceutical and veterinary preparations for erectile dysfunction; pharmaceutical and veterinary preparations for chronic obstructive pulmonary disease; pharmaceutical and veterinary preparations for premature ejaculation; pharmaceutical and veterinary preparations for cystic fibrosis; pharmaceutical and veterinary preparations for female sexual dysfunction; medicaments for migraine; pharmaceutical and veterinary preparations for asthma Inhalers for medical purposes, sold empty; metered dose inhalers for medical purposes, sold empty; active dry powder inhalers for medical purposes, sold empty; passive dry powder inhalers for medical purposes, sold empty; nebulisers for respiration therapy; respirators for artificial respiration and parts and fittings for all the aforesaid goods

Goods & Services

Pharmaceutical and veterinary preparations for the treatment of diseases or conditions of the respiratory system; pharmaceutical and veterinary preparations for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynaecological conditions; pharmaceutical and veterinary preparations for the alleviation or prevention of pain or inflammation; inhalers filled with powders for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynaecological conditions; pharmaceutical preparations, namely, powders for asthma inhalers; pharmaceutical preparations, namely, powders for transdermal injection for the alleviation or prevention of pain, for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; pharmaceutical and veterinary preparations for oral ingestion for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; pharmaceutical and veterinary preparations for topical administration for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; medicaments for inhalation therapy; pharmaceutical preparations, namely, pulmonary delivery compositions for use in facilitating the inhalation of pharmaceuticals, namely, drug delivery agents consisting of compounds that facilitate delivery by inhalation of a wide range of pharmaceuticals; medicaments for the treatment of erectile dysfunction; medicaments for the treatment of chronic obstructive pulmonary disease; medicaments for the treatment of premature ejaculation; medicaments for the treatment of cystic fibrosis; medicaments for the treatment of female sexual dysfunction; medicaments for the treatment of migraines; medicaments for the treatment of asthma; all of the above goods not for use in the dental field Custom manufacture of pharmaceuticals; Consulting services in the field of pharmaceutical formulation, development of medical applications for drugs and pharmaceutical formulations, drug design, drug formulation, pharmaceutical formulation, and development of pharmaceutical formulations Surgical, medical, and veterinary apparatus, instruments and parts and fittings therefor, namely, drug delivery devices and parts and fittings therefor, namely, drug delivery systems being nebulizers for medical purposes; inhalers sold empty for medical or therapeutic purposes and parts and fittings therefor; active dry powder inhalers sold empty for medical or therapeutic purposes and parts and fittings therefor; passive dry powder inhalers sold empty for medical or therapeutic purposes and parts and fittings therefor; nebulisers for inhalation therapy, namely, respiration therapy, and parts and fittings therefor; inhaler devices sold empty for medical or therapeutic purposes and parts and fittings therefor; all of the above goods not for use in the dental field Scientific research and technological services, namely, research, design, analysis, and testing, in the field of pharmaceuticals and drug delivery systems, and drug delivery systems and devices; Scientific research and technological services, namely, research in the field of medicine; industrial analysis and research services in the fields of drug delivery systems and devices; research services in the fields of medicine; pharmaceutical research services; pharmaceutical products development services; device and product safety testing services;

Abstract

The present disclosure relates to the administration of a composition comprising an interferon, azithromycin and chloroquine for the treatment of respiratory conditions.

IPC Classes  ?

• A61K 38/21 - Interferons
• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
• A61P 31/14 - Antivirals for RNA viruses

Abstract

Systems and methods are disclosed for simultaneously jet milling and conditioning particulate material comprising a grinding chamber and an aerosol generator arranged to supply liquid aerosol into the grinding chamber. A composition made by this method is also disclosed.

IPC Classes  ?

• B02C 19/06 - Jet mills
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• B02C 23/18 - Adding fluid, other than for crushing or disintegrating by fluid energy

Abstract

The present disclosure relates to the administration of a composition comprising an interferon, azithromycin and chloroquine for the treatment of respiratory conditions.

IPC Classes  ?

• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
• A61K 38/21 - Interferons
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

A PEGylated polymer is disclosed according to Formula 1 wherein n is any integer from 4 to 200 monomers, and R is a polymer chain comprising a 4 to 200-monomer moiety.

IPC Classes  ?

• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• C08G 69/42 - Polyamides containing atoms other than carbon, hydrogen, oxygen, and nitrogen

Goods & Services

Chemical substances and products for use in the manufacture of medical preparations. Medical preparations; pharmaceutical preparations for medical purposes; biological preparations for medical purposes; pharmaceutical preparations formulated for pulmonary delivery via inhalation; pharmaceutical preparations for the prevention or treatment of diseases or conditions of the respiratory and cardiovascular systems. Medical apparatus and instruments; drug delivery devices; inhalers; metered dose inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers for respiration therapy; respirators for artificial respiration; parts and fittings for all the aforesaid goods. Scientific research, development, design, analysis, testing and investigation relating to medical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development; preparation and formulation of pharmaceuticals; device and product testing.

Goods & Services

Chemical substances and products for use in the manufacture of medical preparations. Medical preparations; pharmaceutical preparations for medical purposes; biological preparations for medical purposes; pharmaceutical preparations formulated for pulmonary delivery via inhalation; pharmaceutical preparations for the prevention or treatment of diseases or conditions of the respiratory and cardiovascular systems. Medical apparatus and instruments; drug delivery devices; inhalers; metered dose inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers for respiration therapy; respirators for artificial respiration; parts and fittings for all the aforesaid goods. Scientific research, development, design, analysis, testing and investigation relating to medical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development; preparation and formulation of pharmaceuticals; device and product testing.

Goods & Services

(1) Chemical substances and products for use in the manufacture of medical preparations for treating respiratory diseases. (2) Medical preparations for treating respiratory diseases; pharmaceutical preparations for treating respiratory diseases; biological preparations for treating respiratory diseases; pharmaceutical preparations formulated for pulmonary delivery via inhalation for treating respiratory diseases; pharmaceutical preparations for the prevention and treatment of diseases and conditions of the respiratory and cardiovascular systems (3) Medical apparatus and instruments, namely, inhalers, metered dose inhalers, active dry powder inhalers and passive dry powder inhalers, and parts and fittings for all the aforesaid goods; nebulisers for respiration therapy, and parts and fittings for all the aforesaid goods; respirators for artificial respiration; and parts and fittings for all the aforesaid goods (1) Scientific research, development, design, analysis, testing and investigation relating to medical preparations and drug delivery devices; medical research; research relating to drug delivery devices namely for treating respiratory diseases; research relating to drug formulation for respiratory diseases; pharmaceutical development; preparation and formulation of pharmaceuticals for treating respiratory diseases; medical devices and product testing in the field of pharmaceutical preparations and drug delivery devices

Goods & Services

(1) Chemical substances and products for use in the manufacture of medical preparations for treating respiratory diseases (2) Medical preparations for treating respiratory diseases; pharmaceutical preparations for treating respiratory diseases; biological preparations for treating respiratory diseases; pharmaceutical preparations formulated for pulmonary delivery via inhalation for treating respiratory diseases; pharmaceutical preparations for the prevention or treatment of diseases or conditions of the respiratory and cardiovascular systems (3) Medical apparatus and instruments, namely, inhalers, metered dose inhalers, active dry powder inhalers and passive dry powder inhalers, and parts and fittings for all the aforesaid goods; nebulisers for respiration therapy, and parts and fittings for all the aforesaid goods; respirators for artificial respiration and parts and fittings for all the aforesaid goods (1) Scientific research, development, design, analysis, testing and investigation relating to medical preparations and drug delivery devices; medical research; research relating to drug delivery devices namely for treating respiratory diseases; research relating to drug formulation for respiratory diseases; pharmaceutical development; preparation and formulation of pharmaceuticals for treating respiratory diseases; medical devices and product testing in the field of pharmaceutical preparations and drug delivery devices

Goods & Services

Chemical additives for use in the manufacture of medical preparations Medical preparations for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynaecological conditions; pharmaceutical preparations for medical purposes for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynaecological conditions; biological preparations for medical purposes for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynaecological conditions; pharmaceutical preparations for treating pulmonary diseases via inhalation; pharmaceutical preparations for the prevention and treatment of diseases and conditions of the respiratory and cardiovascular systems Medical apparatus and instruments, namely inhalers; drug delivery devices, namely inhalers; inhalers for medical use; metered dose inhalers for medical use; active dry powder inhalers for medical use; passive dry powder inhalers for medical use; nebulisers for respiration therapy; respirators for artificial respiration; component parts and fittings for all the aforesaid goods Scientific research relating to medical preparations and drug delivery devices; development and design medical preparations and drug delivery devices; analysis, and investigation in the form of testing of medical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development

Goods & Services

Chemical additives for use in the manufacture of medical preparations Medical preparations for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynaecological conditions; pharmaceutical preparations for medical purposes for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynaecological conditions; biological preparations for medical purposes for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynaecological conditions; pharmaceutical preparations for treating pulmonary diseases via inhalation; pharmaceutical preparations for the prevention and treatment of diseases and conditions of the respiratory and cardiovascular systems Medical apparatus and instruments, namely inhalers; drug delivery devices, namely inhalers; inhalers for medical use; metered dose inhalers for medical use; active dry powder inhalers for medical use; passive dry powder inhalers for medical use; nebulisers for respiration therapy; respirators for artificial respiration; component parts and fittings for all the aforesaid goods Scientific research relating to medical preparations and drug delivery devices; development and design medical preparations and drug delivery devices; analysis, and investigation in the form of testing of medical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development

Abstract

Methods are disclosed for simultaneously jet milling and conditioning particulate glycopyrrolate and magnesium stearate using a milling gas having humidity between 5% and 30% Relative Humidity in the grinding chamber of a jet mill, the jet mill is configured with a humidifier arranged to supply humidity into the grinding chamber. A composition and formulation comprising physically stable micronized composite glycopyrrolate particles made by this method is also disclosed.

IPC Classes  ?

• C07D 207/12 - Oxygen or sulfur atoms
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/4704 - 2-Quinolinones, e.g. carbostyril
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone

Goods & Services

Chemical substances and products for use in the manufacture of medical preparations. Medical preparations; pharmaceutical preparations for medical purposes; biological preparations for medical purposes; pharmaceutical preparations formulated for pulmonary delivery via inhalation; pharmaceutical preparations for the prevention or treatment of diseases or conditions of the respiratory and cardiovascular systems. Medical apparatus and instruments; drug delivery devices; inhalers; metered dose inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers for respiration therapy; respirators for artificial respiration; parts and fittings for all the aforesaid goods. Scientific research, development, design, analysis, testing and investigation relating to medical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development; preparation and formulation of pharmaceuticals; device and product testing.

Goods & Services

Chemical substances and products for use in the manufacture of medical preparations. Medical preparations; pharmaceutical preparations for medical purposes; biological preparations for medical purposes; pharmaceutical preparations formulated for pulmonary delivery via inhalation; pharmaceutical preparations for the prevention or treatment of diseases or conditions of the respiratory and cardiovascular systems. Medical apparatus and instruments; drug delivery devices; inhalers; metered dose inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers for respiration therapy; respirators for artificial respiration; parts and fittings for all the aforesaid goods. Scientific research, development, design, analysis, testing and investigation relating to medical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development; preparation and formulation of pharmaceuticals; device and product testing.

Abstract

The invention relates to a polymorphic form of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridine-3-yl)-1H-imidazo[4,5-b]pyridine-3(2H)-yl)piperidin-1-yl)-3-oxopropanenitrile and use as a therapeutic agent for the treatment of respiratory diseases.

IPC Classes  ?

• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

The present invention concerns a method for making an inhaled pharmaceutical composition with improved powder handling properties comprising a stearate, a method of preparing such a composition, and the use of such a stearate in a composition when dispensed into a receptacle for use in a dry powder inhaler receptacle.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof

Abstract

Methods are disclosed for simultaneously jet milling and conditioning particulate glycopyrrolate and magnesium stearate using a milling gas having humidity between 5% and 30% Relative Humidity in the grinding chamber of a jet mill, the jet mill is configured with a humidifier arranged to supply humidity into the grinding chamber. A composition and formulation comprising physically stable micronized composite glycopyrrolate particles made by this method is also disclosed.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

Abstract

Systems and methods are disclosed for simultaneously jet milling and conditioning particulate material comprising a grinding chamber and an aerosol generator arranged to supply liquid aerosol into the grinding chamber. A composition made by this method is also disclosed.

IPC Classes  ?

• B02C 19/06 - Jet mills
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• B02C 23/18 - Adding fluid, other than for crushing or disintegrating by fluid energy

Abstract

An inhalable powder composition comprises a) an antagonistic antibody which binds human IL-13, b) leucine and c) trehalose. The antibody may comprise a heavy chain, wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:3 and a light chain, wherein the variable domain of the light chain comprises the sequence given in SEQ ID NO:1. Also described is the use of such compositions in the treatment of asthma, as well as inhalers containing such compositions.

IPC Classes  ?

• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

Abstract

The invention relates to novel co-crystals of a drug substance and their use to treat respiratory diseases such as asthma and COPD.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• C07C 57/145 - Maleic acid

Abstract

A PEGylated polymer is disclosed according to Formula 1 wherein n is any integer from 4 to 200 monomers, and R is a polymer chain comprising a 4 to 200‐monomer moiety.

IPC Classes  ?

• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• C08G 69/40 - Polyamides containing oxygen in the form of ether groups
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/51 - Nanocapsules

Abstract

The invention relates to a polymorphic forms of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridine-3-yl)-1H-imidazo[4,5-b]pyridine-3(2H)-yl)piperidin-1-yl)-3-oxopropanenitrile and their use as a therapeutic agent for the treatment of respiratory diseases.

IPC Classes  ?

• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

The invention discloses spray-dried compositions for inhalation and methods for preparing such powder compositions. The compositions of the invention are produced by spray-drying taurine under conditions that (i) retain the physical and chemical stability of the composition during spray drying and upon storage, (ii) protect the powder composition from aggregation and (iii) provide particles suitable for aerosolization.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 31/185 - AcidsAnhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
• A61K 31/4704 - 2-Quinolinones, e.g. carbostyril
• C07C 303/42 - SeparationPurificationStabilisationUse of additives
• C07C 309/14 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine

Abstract

A method is disclosed for making a pharmaceutical composition for pulmonary administration comprising co-jet milling glycopyrrolate and magnesium stearate, wherein the co-jet milled glycopyrrolate and magnesium stearate is then subjected to a conditioning step which includes exposure of the co-jet milled glycopyrrolate and magnesium stearate to humidity. A composition made by this method is also disclosed.

IPC Classes  ?

• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
• A61K 31/4704 - 2-Quinolinones, e.g. carbostyril
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/50 - Microcapsules
• A61K 9/51 - Nanocapsules
• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine

Goods & Services

(1) Pharmaceutical preparations for the treatment of diseases and conditions of the respiratory system none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; pharmaceutical preparations for the treatment of diseases and conditions of the respiratory system, diseases and conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases and conditions of the gastro-intestinal system, diseases and conditions of the central nervous system, namely encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease, Huntington's disease and multiple sclerosis, central nervous system infections, brain diseases, nervous system infections movement disorders, ocular motility disorders, spinal cord diseases, diseases and conditions of the endocrine system, namely growth and thyroid disorders, diseases and conditions of the genito-urinary system, namely, cancer, infertility, sexually transmitted diseases, incontinence, and sexual dysfunction, infectious diseases, namely respiratory infections, bacterial skin infections, fungal skin infections, viral skin infections and parasitic skin infections none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; pharmaceutical preparations for the alleviation and prevention of pain none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; inhalers filled with powders for the treatment of diseases and conditions of the respiratory system, diseases and conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases and conditions of the gastro-intestinal system, diseases and conditions of the central nervous system, namely encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease, Huntington's disease and multiple sclerosis, central nervous system infections, brain diseases, nervous system infections movement disorders, ocular motility disorders, spinal cord diseases, diseases and conditions of the endocrine system, namely growth and thyroid disorders, diseases and conditions of the genito-urinary system, namely, cancer, infertility, sexually transmitted diseases, incontinence, and sexual dysfunction, infectious diseases, namely respiratory infections, bacterial skin infections, fungal skin infections, viral skin infections and parasitic skin infections none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; pharmaceutical preparations, namely, powders for asthma inhalers none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; pharmaceutical preparations, namely, powders for transdermal injection for the alleviation and prevention of pain, for the treatment of diseases and conditions of the respiratory system, diseases and conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases and conditions of the gastro-intestinal system, diseases and conditions of the central nervous system, namely encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease, Huntington's disease and multiple sclerosis, central nervous system infections, brain diseases, nervous system infections movement disorders, ocular motility disorders, spinal cord diseases, diseases and conditions of the endocrine system, namely growth and thyroid disorders, diseases and conditions of the genito-urinary system, namely, cancer, infertility, sexually transmitted diseases, incontinence, and sexual dysfunction, infectious diseases, namely respiratory infections, bacterial skin infections, fungal skin infections, viral skin infections and parasitic skin infections none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; pharmaceutical preparations for oral ingestion for the treatment of diseases and conditions of the respiratory system, diseases and conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases and conditions of the gastro-intestinal system, diseases and conditions of the central nervous system, namely encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease, Huntington's disease and multiple sclerosis, central nervous system infections, brain diseases, nervous system infections movement disorders, ocular motility disorders, spinal cord diseases, diseases and conditions of the endocrine system, namely growth and thyroid disorders, diseases and conditions of the genito-urinary system, namely, cancer, infertility, sexually transmitted diseases, incontinence, and sexual dysfunction, infectious diseases, namely respiratory infections, bacterial skin infections, fungal skin infections, viral skin infections and parasitic skin infections none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; pharmaceutical preparations for topical administration for the treatment of diseases and conditions of the respiratory system, diseases and conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases and conditions of the gastro-intestinal system, diseases and conditions of the central nervous system, namely encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease, Huntington's disease and multiple sclerosis, central nervous system infections, brain diseases, nervous system infections movement disorders, ocular motility disorders, spinal cord diseases, diseases and conditions of the endocrine system, namely growth and thyroid disorders, diseases and conditions of the genito-urinary system, namely, cancer, infertility, sexually transmitted diseases, incontinence, and sexual dysfunction, infectious diseases, namely respiratory infections, bacterial skin infections, fungal skin infections, viral skin infections and parasitic skin infections none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; inhaled pharmaceutical preparations for the treatment of respiratory diseases and disorders none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; drug delivery agents in the form of powders that provide controlled release of the active ingredients for a wide variety of pharmaceuticals none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; medicaments for the treatment of erectile dysfunction none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; medicaments for the treatment of chronic obstructive pulmonary disease none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; medicaments for the treatment of premature ejaculation none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; medicaments for the treatment of cystic fibrosis none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; medicaments for the treatment of female sexual dysfunction none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; medicaments for the treatment of migraines none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions; medicaments for the treatment of asthma, none of the aforesaid wares are for use in the veterinary field or for use in association with autoimmune and inflammatory diseases and conditions.

Goods & Services

Medical preparations; pharmaceutical preparations for medical purposes; biological preparations for medical purposes; pharmaceutical preparations formulated for pulmonary delivery via inhalation; pharmaceutical preparations for the prevention or treatment of diseases or conditions of the respiratory and cardiovascular systems. Medical apparatus and instruments; inhalers; metered dose inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers for respiration therapy; respirators for artificial respiration; parts and fittings for all the aforesaid goods. Scientific research, development, design, analysis, testing and investigation relating to medical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development; preparation and formulation of pharmaceuticals; device and product testing.

Abstract

Systems and methods are disclosed for simultaneously jet milling and conditioning particulate material comprising a grinding chamber and an aerosol generator arranged to supply liquid aerosol into the grinding chamber. A composition made by this method is also disclosed.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• B02C 19/06 - Jet mills

Goods & Services

Medical preparations; pharmaceutical preparations for medical purposes; biological preparations for medical purposes; pharmaceutical preparations formulated for pulmonary delivery via inhalation; pharmaceutical preparations for the prevention or treatment of diseases or conditions of the respiratory and cardiovascular systems. Medical apparatus and instruments; drug delivery devices; inhalers; metered dose inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers for respiration therapy; respirators for artificial respiration; parts and fittings for all the aforesaid goods. Scientific research, development, design, analysis, testing and investigation relating to medical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development; preparation and formulation of pharmaceuticals; device and product testing.

Abstract

The invention relates to novel co-crystals of a drug substance and their use to treat respiratory diseases such as asthma and COPD.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

The invention relates to polymorphic forms of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]py yl)-1H-imidazo[4,5-b]pyridine-3(2H)-yl)piperidin-1-yl)-3-oxopropanenitrile and their use as therapeutic agents for the treatment of respiratory diseases.

IPC Classes  ?

• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61P 11/06 - Antiasthmatics

Goods & Services

Chemical substances and products for use in the manufacture of medical preparations. Medical preparations; pharmaceutical preparations for medical purposes; biological preparations for medical purposes; pharmaceutical preparations formulated for pulmonary delivery via inhalation; pharmaceutical preparations for the prevention or treatment of diseases or conditions of the respiratory and cardiovascular systems. Medical apparatus and instruments; drug delivery devices; inhalers; metered dose inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers for respiration therapy; respirators for artificial respiration; parts and fittings for all the aforesaid goods. Scientific research, development, design, analysis, testing and investigation relating to medical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development; preparation and formulation of pharmaceuticals; device and product testing.

Goods & Services

Chemical substances and products for use in the manufacture of medical preparations. Medical preparations; pharmaceutical preparations for medical purposes; biological preparations for medical purposes; pharmaceutical preparations formulated for pulmonary delivery via inhalation; pharmaceutical preparations for the prevention or treatment of diseases or conditions of the respiratory and cardiovascular systems. Medical apparatus and instruments; drug delivery devices; inhalers; metered dose inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers for respiration therapy; respirators for artificial respiration; parts and fittings for all the aforesaid goods. Scientific research, development, design, analysis, testing and investigation relating to medical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development; preparation and formulation of pharmaceuticals; device and product testing.

Goods & Services

Chemical substances and products for use in the manufacture of medical preparations. Medical preparations; pharmaceutical preparations for medical purposes; biological preparations for medical purposes; pharmaceutical preparations formulated for pulmonary delivery via inhalation; pharmaceutical preparations for the prevention or treatment of diseases or conditions of the respiratory and cardiovascular systems. Medical apparatus and instruments; drug delivery devices; inhalers; metered dose inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers for respiration therapy; respirators for artificial respiration; parts and fittings for all the aforesaid goods. Scientific research, development, design, analysis, testing and investigation relating to medical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development; preparation and formulation of pharmaceuticals; device and product testing.

Abstract

A method is disclosed for making a pharmaceutical composition for pulmonary administration comprising co-jet milling glycopyrrolate and magnesium stearate, wherein the co-jet milled glycopyrrolate and magnesium stearate is then subjected to a conditioning step which includes exposure of the co-jet milled glycopyrrolate and magnesium stearate to humidity. A composition made by this method is also disclosed.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/00 - Medicinal preparations containing organic active ingredients

Abstract

The present invention concerns a method for making an inhaled pharmaceutical composition with improved powder handling properties comprising a stearate, a method of preparing such a composition, and the use of such a stearate in a composition when dispensed into a receptacle for use in a dry powder inhaler receptacle.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof

Abstract

A method is disclosed for making a pharmaceutical composition for pulmonary administration comprising a pharmaceutically active protein or nucleic acid particle, the method comprising a step in which the inhalable pharmaceutically active protein or nucleic acid particle is acoustically blended in a resonant acoustic blender. The invention also relates to compositions for inhalation prepared by the method.

IPC Classes  ?

• A61K 9/72 - Medicinal preparations characterised by special physical form for smoking or inhaling
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• B01F 11/02 - Mixing by means of ultrasonic vibrations

Abstract

The present invention concerns a method for making an inhaled pharmaceutical composition with improved powder handling properties comprising a stearate, a method of preparing such a composition, and the use of such a stearate in a composition when dispensed into a receptacle for use in a dry powder inhaler receptacle.

IPC Classes  ?

• A61K 9/72 - Medicinal preparations characterised by special physical form for smoking or inhaling

Abstract

The invention discloses spray-dried compositions for inhalation and methods for preparing such powder compositions. The compositions of the invention are produced by spray-drying taurine under conditions that (i) retain the physical and chemical stability of the composition during spray drying and upon storage, (ii) protect the powder composition from aggregation and (iii) provide particles suitable for aerosolisation.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
• C07C 309/14 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

A dry powder formulation suitable for delivery by inhalation comprising an antifungal agent and a force control agent.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin

Abstract

N-containing heteroaryl derivatives of formula I or II, wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK, particularly JAK3, kinase inhibitors.

IPC Classes  ?

• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• C07D 471/04 - Ortho-condensed systems
• C07D 473/00 - Heterocyclic compounds containing purine ring systems
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

A method is disclosed for making a pharmaceutical composition for pulmonary administration, the method comprising a step in which an inhalable pharmaceutically active material is acoustically blended in a resonant acoustic blender. The invention also relates to compositions for inhalation prepared by the method.

IPC Classes  ?

• B01F 11/02 - Mixing by means of ultrasonic vibrations
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

N-containing heteroaryl derivatives of formula I or II, wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK, particularly JAK3, kinase inhibitors.

IPC Classes  ?

• A61K 31/52 - Purines, e.g. adenine
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• C07D 473/00 - Heterocyclic compounds containing purine ring systems

Abstract

A method of processing an active ingredient, the method comprising submitting a pharmaceutically active ingredient in the absence of excipients and/or additives to compression and shearing forces. The invention also relates to compositions comprising an active prepared by the method.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/404 - Indoles, e.g. pindolol
• B02C 23/00 - Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in groups or not specially adapted to apparatus covered by one only of groups
• C07D 209/16 - Tryptamines
• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

According to the invention there is provided heparin for use in the treatment of COPD, wherein, after administration to a subject, the heparin reduces inflammation in the lungs of the subject.

IPC Classes  ?

• A61K 31/726 - Glycosaminoglycans, i.e. mucopolysaccharides
• A61K 31/727 - HeparinHeparan
• A61P 11/06 - Antiasthmatics
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

According to the invention there is provided a method of treating and/or preventing the symptoms of Parkinson's disease comprising delivering apomorphine, optionally in combination with levodopa and/or a dopamine agonist that is not apomorphine, wherein apomorphine is administered by inhalation.

IPC Classes  ?

• A61K 31/195 - Carboxylic acids, e.g. valproic acid having an amino group
• A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
• A61K 31/275 - NitrilesIsonitriles
• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61K 31/48 - Ergoline derivatives, e.g. lysergic acid, ergotamine
• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
• A61P 25/16 - Anti-Parkinson drugs

Goods & Services

(1) Inhalers for therapeutic use. (1) Scientific research, development, design, analysis, testing and investigation in the field of pharmaceutical preparations and drug delivery devices; medical research; research in the field of drug delivery devices; research in the field of drug formulation; pharmaceutical developments; preparation and formulation of pharmaceuticals; medical device testing services; exploitation of intellectual property, namely provision of licenses for pharmaceutical preparations, substances and products; provision of licences for medical apparatus and instruments; provision of licences for drug delivery devices; provision of licenses for pharmaceutical preparations for pulmonary delivery; provision of licences for intellectual property.

Abstract

The present invention relates to suspension formulations, especially those for delivering a pharmaceutically active agent in aerosol form using a spray or aerosol device, such as a pressurized metered dose inhaler (pMDI). The formulations may be for pulmonary, nasal, buccal or topical administration, but are preferably for pulmonary inhalation.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61K 9/12 - AerosolsFoams
• A61P 11/08 - Bronchodilators
• A61P 11/06 - Antiasthmatics
• B29B 9/16 - Auxiliary treatment of granules
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

A method of processing an active ingredient, the method comprising submitting a pharmaceutically active ingredient in the absence of excipients and/or additives to compression and shearing forces. The invention also relates to compositions comprising an active prepared by the method.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/51 - Nanocapsules
• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin

Goods & Services

Chemical substances and products for use in the manufacture of medical preparations. Pharmaceutical and veterinary preparations, substances and products; chemical preparations and products for medical and veterinary purposes, all for administration to human or animal patients; pharmaceutical preparations for pulmonary delivery; inhalants; powders for inhalers; powders for asthma inhalers; powders for transdermal injection; pharmaceutical and veterinary preparations for oral ingestion; pharmaceutical and veterinary preparations for topical administration; all the above goods not for use in the dental field. Medical and veterinary apparatus, articles and aids, all for the administration of pharmaceutical preparations to human or animal patients; devices for the administration of pharmaceutical preparations; drug delivery devices; devices for metering and/or dispensing pharmaceutical preparations; inhalers; dry powder inhalers; inhalers for the treatment of asthma; nebulisers;  parts and fittings for all the aforesaid goods; all the above goods not for use in the dental field. Scientific research, development, design, analysis, testing and investigation relating to pharmaceutical preparations and drug delivery devices; medical research; research relating to drug delivery devices; research relating to drug formulation; pharmaceutical development; preparation and formulation of pharmaceuticals; device and product testing; exploitation of intellectual property; provision of licences for pharmaceutical preparations, substances and products; provision of licences for medical and veterinary apparatus and instruments; provision of licences for drug delivery devices; provision of licenses for pharmaceutical preparations for pulmonary delivery; provision of licences for intellectual property.

Abstract

The present invention relates to suspension formulations, especially those for delivering a pharmaceutically active agent in aerosol form using a spray or aerosol device, such as a pressurised metered dose inhaler (pMDI). The formulations may be for pulmonary, nasal, buccal or topical administration, but are preferably for pulmonary inhalation. The suspension fomulation comprises particles of active agent, a propellant one or more suspension stabiliser (amino acid, leucine, saccharide, disaccharide, trehalose) and/or a co-solvent (alcohol, ethanol).

IPC Classes  ?

• A61K 9/12 - AerosolsFoams
• A61K 9/72 - Medicinal preparations characterised by special physical form for smoking or inhaling

Abstract

The present invention relates to pharmaceutical compositions comprising triptans, such as sumatriptan, and their uses in therapy. In particular, the invention relates to compositions for administration via the inhaled route.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/72 - Medicinal preparations characterised by special physical form for smoking or inhaling
• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61P 25/06 - Antimigraine agents

Abstract

The present invention relates to improved treatment of diseases and disorders of the central nervous system by administration of apomorphine. In particular, the administration is via pulmonary inhalation. The invention provides the means for improving the treatment of a number of conditions, including Parkinson's Disease.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/72 - Medicinal preparations characterised by special physical form for smoking or inhaling
• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
• A61P 25/16 - Anti-Parkinson drugs

Abstract

The present invention relates to inhaler devices and bespoke pharmaceutical dry powder composition to be dispensed using such inhaler devices for pulmonary administration. In particular, the present invention relates to the provision of passive inhaler devices and dry powder compositions which are specifically formulated and prepared to be efficiently dispensed by such devices to reproducibly achieve a high delivered dose of the pharmaceutically active agent.

IPC Classes  ?

• A61K 9/72 - Medicinal preparations characterised by special physical form for smoking or inhaling
• A61M 15/00 - Inhalators

Abstract

The present invention relates to the treatment of dry powder formulations, doses of which are measured out and placed into receptacles such as blisters or capsules, to be dispensed by a dry powder inhaler device (DPI). In particular, the present invention relates to methods of agitating a dose of a dry powder formulation to ensure that any compacted powder is broken up. It is easier to extract a loose powder from a receptacle than it is to extract powder which is compacted and so ensuring that the powder in a receptacle is not compacted can, in turn, lead to improvements in the administration of the powder formulation to the lung of the patient.

IPC Classes  ?

• A61M 15/00 - Inhalators
• B01F 11/02 - Mixing by means of ultrasonic vibrations
• B65B 1/24 - Reducing volume of filled material by mechanical compression

Goods & Services

Pharmaceutical and veterinary preparations; medicaments formulated for pulmonary delivery; medicaments for inhalation; medicaments for erectile dysfunction; medicaments for chronic obstructive pulmonary disease; medicaments for premature ejaculation; medicaments for cystic fibrosis; medicaments for female sexual dysfunction; medicaments for migraine; medicaments for asthma. Surgical, medical, dental and veterinary apparatus and instruments, drug delivery devices; inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers; parts and fittings for all of the aforesaid goods. Paper, cardboard and goods made from these materials, not included in other classes; printed matter; photographs; stationery; instructional and teaching material (except apparatus); plastic materials for packaging (not included in other classes); all the aforesaid being goods relating to pharmaceuticals or drug delivery devices. Scientific and technological services and research and design relating thereto; industrial analysis and research services; pharmaceutical development services; preparation and/or formulation of pharmaceuticals; device and product testing services.

Goods & Services

Pharmaceutical and veterinary preparations; medicaments formulated for pulmonary delivery; medicaments for inhalation; medicaments for erectile dysfunction; medicaments for chronic obstructive pulmonary disease; medicaments for premature ejaculation; medicaments for cystic fibrosis; medicaments for female sexual dysfunction; medicaments for migraine; medicaments for asthma. Surgical, medical, dental and veterinary apparatus and instruments, drug delivery devices; inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers; parts and fittings for all of the aforesaid goods, but not including arthroscopic surgical instruments. Scientific and technological services and research and design relating thereto; industrial analysis and research services; pharmaceutical development services; preparation and/or formulation of pharmaceuticals; device and product testing services.

Abstract

The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/12 - AerosolsFoams
• A61K 9/14 - Particulate form, e.g. powders

Goods & Services

Chemicals for use in science and industry; chemical substances and products for use in the manufacture of medical preparations; chemicals for use in the manufacture of powders for medicinal use. Pharmaceutical and veterinary preparations; pharmaceutical and veterinary preparations for the treatment of diseases or conditions of the respiratory system; pharmaceutical and veterinary preparations for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; pharmaceutical and veterinary preparations for the alleviation or prevention of pain or inflammation; inhalers filled with powders for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; powders for asthma inhalers; powders for transdermal injection for the alleviation or prevention of pain, for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; pharmaceutical and veterinary preparations for oral ingestion for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; pharmaceutical and veterinary preparations for topical administration for the treatment of diseases or conditions of the respiratory system, diseases or conditions of the cardiovascular system, diabetes, cancer, arthritis, diseases or conditions of the gastro-intestinal system, diseases or conditions of the central nervous system, diseases or conditions of the endocrine system, diseases or conditions of the genito-urinary system, infections, skin disorders and gynecological conditions; pharmaceutical and veterinary preparations for erectile dysfunction; pharmaceutical and veterinary preparations for chronic obstructive pulmonary disease; pharmaceutical and veterinary preparations for premature ejaculation; pharmaceutical and veterinary preparations for cystic fibrosis; pharmaceutical and veterinary preparations for female sexual dysfunction; medicaments for migraine; pharmaceutical and veterinary preparations for asthma. Printed matter; leaflets, brochures, labels, booklets, manuals, magazines, books, guides, pamphlets, catalogues, journals, newsletters, press releases, dossiers being collections of scientific papers, patient record cards, prescription pads, posters; packaging for pharmaceuticals and medical devices; instructional and teaching material, worksheets, work books, notes and note books, slides and images, pre-recorded CD-ROMs. Scientific and technological services and research and design relating thereto; industrial analysis and research services; medical and veterinary device development services; pharmaceutical development services; pharmaceutical delivery system development services; preparation and/or formulation of pharmaceuticals; medical and veterinary device and product testing services.

Goods & Services

Pharmaceutical and veterinary preparations; medicaments formulated for pulmonary delivery; medicaments for inhalation; medicaments for erectile dysfunction; medicaments for chronic obstructive pulmonary disease; medicaments for premature ejaculation; medicaments for cystic fibrosis; medicaments for female sexual dysfunction; medicaments for migraine; medicaments for asthma. Surgical, medical, dental and veterinary apparatus and instruments, drug delivery devices; inhalers; active dry powder inhalers; passive dry powder inhalers; nebulisers; parts and fittings for all of the aforesaid goods. Paper, cardboard and goods made from these materials, not included in other classes; printed matter; photographs; stationery; instructional and teaching material (except apparatus); plastic materials for packaging (not included in other classes); all the aforesaid being goods relating to pharmaceuticals or drug delivery devices. Education; providing of training; all the aforesaid being services relating to pharmaceuticals or drug delivery devices. Scientific and technological services and research and design relating thereto; industrial analysis and research services; pharmaceutical development services; preparation and/or formulation of pharmaceuticals; device and product testing services.

Goods & Services

(1) Scientific and technological services and research and design relating thereto; industrial analysis and research services; all the aforesaid being services relating to pharmaceuticals or drug delivery devices; pharmaceutical development services; preparations and/or formulation of pharmaceuticals; medical device and medical product testing services; pharmaceutical product development.

Goods & Services

Chemical substances and products for use in the manufacture of medical preparations. Pharmaceutical and veterinary preparations, substances and products; chemical preparations and products for medical and veterinary purposes; all for administration to human or animal patients; inhalants; powders for inhalers; powders for asthma inhalers; powders for transdermal injection; pharmaceutical and veterinary preparations for oral ingestion; pharmaceutical and veterinary preparations for topical administration; all the above goods not for use in the dental field. Medical and veterinary apparatus, articles and aids and parts and fittings therefor; all for the administration of pharmaceutical preparations to human or animal patients; devices for the administration of pharmaceutical preparations; devices for metering and/or dispensing pharmaceutical preparations, inhalers and parts and fittings therefor; inhalers for the treatment of asthma and parts and fittings therefor; aerosol dispensers; all the above goods not for use in the dental field. Scientific research, development, design, testing and investigation relating to pharmaceutical preparations; medical research; research relating to drug delivery devices; research relating to drug formulation.