The present disclosure is directed to hybrid-bonded siliceous materials. The materials of the present disclosure exhibit enhanced base stability and reduced baseline noise. As such, the materials disclosed herein are suitable for use across a range of chromatography applications, including size-exclusion chromatography and reversed-phase chromatography.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
Disclosed herein are methods for the multiplexed characterization of analytes using dye-tagged affinity molecules. The DTAMs, useful in conjunction with liquid chromatography systems, allow for the parallel quantitation and characterization of attributes of one or more target analytes from complex solutions.
The present disclosure is directed to hybrid-bonded siliceous materials. The materials of the present disclosure exhibit enhanced base stability and reduced baseline noise. As such, the materials disclosed herein are suitable for use across a range of chromatography applications, including size-exclusion chromatography and reversed-phase chromatography.
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
Disclosed herein are methods for the multiplexed characterization of analytes using dye-tagged affinity molecules. The DTAMs, useful in conjunction with liquid chromatography systems, allow for the parallel quantitation and characterization of attributes of one or more target analytes from complex solutions.
A frit and a chromatography column that includes the frit are described. The frit is formed as a disk having a porosity, a radius and a thickness. The disk has a variation in porosity, thickness, or both porosity and thickness along a radial direction. A flow of a liquid through an outer region of the disk is advanced at an outlet end of the disk relative to a flow of the liquid through an inner region of the disk. The frit is configured to be disposed at one end of a column bed of a liquid chromatography column where the advance in the flow in the outer region relative to the flow in the inner region is predetermined to at least partially compensate for a radial variation in the linear velocity of the flow through the column bed.
A frit and a chromatography column that includes the frit are described. The frit is formed as a disk having a porosity, a radius and a thickness. The disk has a variation in porosity, thickness, or both porosity and thickness along a radial direction. A flow of a liquid through an outer region of the disk is advanced at an outlet end of the disk relative to a flow of the liquid through an inner region of the disk. The frit is configured to be disposed at one end of a column bed of a liquid chromatography column where the advance in the flow in the outer region relative to the flow in the inner region is predetermined to at least partially compensate for a radial variation in the linear velocity of the flow through the column bed.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Promoting the exchange of information and resources within the laboratory research community to achieve advances in the field of the separation sciences; Promoting the exchange of information and resources within the laboratory research community to achieve advances in the fields of chemistry, biochemistry, pharmaceuticals, environmental science, material science, and material characterization; business consulting services in best practices for laboratory research in the field of chemistry, biochemistry pharmaceutical science, forensic toxicology, food science, environmental science, material science, and material characterization; Providing facilities for business meetings; online, catalog, and mail order services featuring analytical apparatus and instruments for scientific and research use; online, catalog, and mail order services featuring computer operating software for analytical apparatus and instruments, analyzing and manipulating data; online, catalog, and mail order services featuring computer operating software data acquisition, processing, and reporting Chemical test kits for indicating the presence or absence of toxins; chemical and biochemical reagents for non-medical purposes for indicating the presence or absence of toxins; chemically treated non-medical test strips for indicating the presence or absence of toxins; reagents for laboratory use; reagents for scientific and research use; analytical standard solutions and reagents for scientific and research use; analytical standard solutions and reagents for testing soil for the purpose of monitoring contaminants; chromatography chemicals; sample preparation kits for scientific and research purposes, comprising biological standards, namely, monoclonal antibodies, and chemical reagents for biological analysis; chemical reagents for preparing samples for chromatography and mass spectrometry for non-medical, laboratory use; chemicals, namely, buffers and standard solutions used in analytical chemistry; buffers in the nature of chemicals used in analytical chemistry; chemically-treated non-medical test strips and test-strip holders specifically adapted for, and sold with, the aforementioned test strips for the detection of mycotoxins by antibody affinity reactions in grain, feed, and food products; assay kits comprising an affinity chromatography column and chemical reagents for testing for mycotoxin contamination in grain, feed, and food products; environmental quality control fluid, gas, and soil samples for calculating standards for testing and verifying the quality of soil and air A house mark for a full line of analytical apparatus and instruments for laboratory use and their parts, fittings, and accessories therefor; A housemark for analytical apparatus and instruments for performing biological testing, physical testing, biological and chemical separation, purification, screening and identification; A housemark for laboratory instruments, namely, chromatography and spectrometry instruments for laboratory use; A housemark for a full line of material testing laboratory instruments; Laboratory apparatus and instruments for solid phase extraction; positive pressure manifolds for chromatography instruments; laboratory analytical instruments for detecting and measuring visual and ultraviolet light; laboratory analytical instruments for detecting and measuring fluorescence; laboratory analytical instruments, namely, ultraviolet and visual light sensors; laboratory analytical instruments, namely, photodiode array sensors; laboratory analytical instruments, namely, evaporative light scattering detectors; laboratory analytical instruments, namely, refractive index detectors; analytical instruments featuring light-guiding flow cell for performing and analyzing biological and chemical samples, not for medical use; wheeled carts specially adapted for laboratory instruments; laboratory instruments for organizing, storing, and processing laboratory samples in a temperature controlled environment; fluid temperature control system for laboratory use and scientific purposes; laboratory instrument for controlling sample temperature; laboratory instrument for controlling sample temperature for use in connection with laboratory automation systems; laboratory instruments for processing samples with liquid chromatography columns; laboratory instruments for heating and cooling laboratory samples and chromatography columns; chromatography columns for laboratory use featuring radio frequency identification (RFID) transponders; radio frequency identification (RFID) transponders and readers for use with chromatography columns; radio frequency radio frequency identification (RFID) transponders, tags, labels, and stickers sold as components of a chromatography column; analytical laboratory instruments for automating sample analyses, diluting samples, tracking and tracing results of sample processing; spectral detectors for use in connection with mass spectrometers and liquid chromatographs not for medical use; detectors for detecting and quantifying ultraviolet and visible spectral exposure for laboratory use; florescence detectors for analysis and detection of samples containing chemiluminescent properties for laboratory use; laboratory robots; laboratory robots used for the purpose of handling laboratory pipettes; laboratory pipettes; automated laboratory pipettes; electronic laboratory pipettes; automated pipetting instrument for laboratory use for use in connection with liquid chromatography or mass spectrometry; pipette racks for laboratory use; pipette tips for laboratory use; pipette accessories, namely, magnetic beads used for laboratory use for DNA and RNA extraction within pipette tips; laboratory equipment and apparatus, namely, magnetic beads for laboratory use for use in purifying genomic, plasmid and mitochondrial DNA; accessories for analytical apparatus and instruments for scientific and laboratory research purposes, namely, Peltier plates in the nature of electrical cooling and heating plates for cooling and heating laboratory samples; laboratory equipment, namely, orbital shakers for laboratory use; automated laboratory sample extraction instruments comprised of vacuum control valves and alignment posts; laboratory equipment and apparatus, namely, column tube grippers and microplate grippers for transfer of centrifuge tubes and microplates; laboratory equipment and supplies, namely, microfluidic chips for analyzing RNA and DNA; magnetic blocks for holding, organizing, agitating, stirring, heating, cooling, and storing consumables for laboratory use; laboratory equipment and supplies, namely, glass bottles, tanks, tubes, vials, and caps for tubes for laboratory use; laboratory equipment and supplies, namely, plastic tubes and bottles for laboratory use; plates for collecting and analyzing samples, namely, optimization plates, elution plates, photoredox plates, and well plates having multi-well arrays that can be used in chemical analysis, biological analysis or patterning for scientific or laboratory research use; non-medical immunostaining racks for scientific or laboratory purposes; disposable reusable dispenser syringes for laboratory sample use, not for medical use; laboratory instrument for measuring and locating the liquid levels of consumables for laboratory use in the nature of liquid level sensors; computer hardware for laboratory, scientific, and clinical use for use in managing laboratory operations and analyzing laboratory samples; electronic measurement systems, namely light scattering photometers, differential refractometers, online particle fractionators for use with light scattering photometers, sonication (non-chemical) optical flow cell cleaners; laboratory apparatus and instruments, namely multi-angel light scattering instruments; Laboratory apparatus and instruments, namely dynamic light scattering instruments; Laboratory apparatus and instruments, namely electrophoretic light scattering instruments; Laboratory apparatus and instruments, namely field-flow fractionation instruments; Laboratory analytical instruments for measuring and characterizing molecular molar mass, molecular size, molecular charge, molecular interaction, molecular shape and confirmation, and molecular conjugation and bonding; computer laboratory workstations comprised of downloadable and recorded software for scientific, clinical, and diagnostic laboratory use, namely, for use in managing laboratory operations, analyzing laboratory samples, and automating laboratory experiments; downloadable or recorded application programming interface (API) software; downloadable or recorded software for analyzing materials by measuring changes in the physical or chemical properties of the material as the material is subjected to controlled changes in its environment; downloadable or recorded software for analyzing samples for compliance with environmental regulations; downloadable or recorded software for analyzing samples for toxins or contaminants; downloadable or recorded software for automating chromatography and mass spectrometry operations in a chromatography and mass spectrometry apparatus; downloadable or recorded software for automating laboratory instruments; downloadable or recorded software for automating pipetting; downloadable or recorded software for calibrating pipettes; downloadable or recorded software for collecting, analyzing, organizing, storing, and reporting data for use in scientific analysis; downloadable or recorded software for collecting, analyzing, organizing, storing, and reporting chromatography and mass spectrometry data; downloadable or recorded software for collecting, analyzing, organizing, storing, and reporting data from analytical equipment in the chemical, pharmaceutical, life sciences, environmental, clinical diagnostic, food science and safety, and forensic toxicology fields; downloadable or recorded software for controlling chromatography and spectrometry instruments; downloadable or recorded software for controlling laboratory instruments; downloadable or recorded software for creating and executing laboratory methods and protocols; downloadable or recorded software for data analysis for laboratory instruments and laboratory data; downloadable or recorded software for facilitating laboratory compliance with government regulation; downloadable or recorded software for identifying and analyzing the components of a sample; downloadable or recorded software for laboratory analytical method development, testing, and validation management, namely, for creating, testing, and validating methods for using analytical instruments for laboratory use; downloadable or recorded software for laboratory and laboratory sample management; downloadable or recorded software for laboratory informatics; downloadable or recorded software for laboratory robot control; downloadable or recorded software for laboratory, scientific, and clinical use, namely, computer software for use in managing laboratory operations and analyzing laboratory samples; downloadable or recorded software for managing laboratory workflow, namely, software for controlling, organizing, and tracking laboratory testing projects, laboratory test results, laboratory staff utilization, and reagent and sample inventories; downloadable or recorded software for operating laboratory instruments; downloadable or recorded software for purification of samples in chromatography and spectrometry applications; downloadable or recorded software for use in connection with light scattering and refractive index detection, data acquisition applications, and liquid chromatographic separations; downloadable or recorded software for validating pipette performance; downloadable or recorded software for validating processes in chromatography and mass spectrometry laboratories; downloadable or recorded software for validating processes in laboratories; analytical apparatus and instruments for performing biological testing, physical testing, biological and chemical separation, purification, screening and identification and structural parts and structural fittings therefor, namely, liquid chromatography apparatus and instruments for laboratory use and structural parts and structural fittings therefor, gas chromatography apparatus for laboratory use and structural parts and structural fittings therefor, ion mobility chromatography apparatus for laboratory use and structural parts and structural fittings therefor, mass spectrometry apparatus and instruments for laboratory use and structural parts and structural fittings therefor; analytical apparatus and instruments, namely, detectors for indicating the presence or absence of toxins in the fields of agriculture and food processing and structural parts and structural fittings therefor; analytical apparatus and instruments for laboratory use, namely, magnetic suspension balances and structural parts and structural fittings therefor; analytical apparatus and instruments for laboratory use, namely, mechanical testing instruments, rubber testing instruments and structural parts and structural fittings therefor; scientific analytical apparatus and instruments in the nature of magnetic suspension balances for isothermal measuring equilibrium and kinetics of ad- or absorption processes and for thermogravimetric measurements at high temperatures and high pressures, gravimetric analysis, thermogravimetric analysis or sorption analysis and structural parts and structural fittings therefor; analytical apparatus and instruments for laboratory use for gas and vapor dosing, mixing, and pressure control and structural parts and structural fittings therefor; analytical apparatus and instruments for laboratory use, namely, electrosurgical instruments used with analytical instruments to identify the presence or absence of toxins in sample tissues, electrosurgical smoke evaluation devices, devices for identification of chemicals in electrosurgical smoke for non-medical diagnostic and analytical purposes; fluorometers and structural parts and structural fittings therefor; lateral flow readers and structural parts and structural fittings therefor; rheometers and structural parts and structural fittings therefor; calorimeters and structural parts and structural fittings therefor; dilatometers and structural parts and structural fittings therefor; laboratory chemical reactors; diagnostic apparatus for testing food; diagnostic apparatus for testing agricultural products; diagnostic apparatus for the detection and identification of microbes and pathogens for laboratory or research use; diagnostic apparatus for testing for illegal drugs, diagnostic apparatus for forensic toxicology; chromatography columns for laboratory use; laboratory consumables, namely, vials, containers, sample trays, sample plates, sample containers, tubing, cartridges, pipettes; solid phase extraction cartridges and plates for laboratory use; affinity columns, comprising monoclonal antibodies, for purifying samples for subsequent liquid-chromatography and mass-spectrometry testing for mycotoxin contamination in grain, feed, and food products; computer operating software for analytical apparatus and instruments; computer operating software for analyzing materials by measuring changes in the physical or chemical properties of the materials; computer operating software for bioinformatics, laboratory data analysis, analysis and visualization of data from liquid chromatography and mass spectrometry instruments, discovery, identification, and analysis of chemical compounds; computer operating software for analyzing materials by measuring changes in the physical or chemical properties of the material as the material is subjected to controlled changes in its environment; analytical apparatus and instruments for laboratory use, namely, flash diffusivity analyzers and parts thereof; mechanical testing instruments, for testing the mechanical or material properties of test samples; mass spectrometer and parts thereof; analytical apparatus and instruments for analyzing mechanical or material properties of material samples for scientific research purposes, namely, thermal analyzers, thermal conductivity meters; laboratory instruments, namely, specimen testing instruments used to apply cyclic and static loads to a specimen integrated with a controller used for fatigue testing and material testing of the specimen subjected to loads; rheometers for measuring the viscosity and viscoelasticity of fluids, and parts and therefor; laboratory chemical reactors and parts thereof; laboratory instruments, namely, autosamplers; laboratory instruments, namely, pressure cells in the nature of vessels that can withstand high internal pressures; computer operating software for analyzing materials by measuring changes in the physical or chemical properties of the material as the material is subjected to controlled changes in its environment; accessories for use with analytical apparatus and instruments for scientific research purposes, namely, grips and platens, stent and graft testers, cylinders, equipment for cutting specimens, and temperature control units; accessories for analytical apparatus and instruments for scientific research purposes, namely, peltier plate systems in the nature of electrical heating and cooling plates, plate pressure cells in the nature of vessels that can withstand high internal pressures, sensors for sensing the mechanical and material properties of samples, temperature, pressure, motion, distances, force, torque, viscosity, elasticity, material strain, tension, deflection, compression, electrically heated cylinders in the nature of test chambers, relative humidity sensors, optical plates, modular microscope accessory in the nature of microscopes, environmental test chambers, namely, temperature simulation equipment, small angle light scattering diodes, interfacial rheology accessories, namely, accessories for analyzing viscoelasticity, tribo-rheometry accessories, namely, accessories for analyzing friction, magneto-rheology accessories, namely, accessories for analyzing properties of materials subject to magnetic fields, electro-rheology accessories, namely, accessories for analyzing properties of materials subject to electric currents, UV curing accessories, namely, accessories for analyzing properties of materials subject to ultraviolet radiation, dieletric measurement accessories, namely, accessories for analyzing properties of materials subject to an oscillating electrical field, diaelectric thermal analysis accessories, namely, accessories for analyzing properties of materials subject to controlled temperatures and an oscillating electrical field, immobilization cells, namely, test chambers for characterizing the drying, retention, and immobilization kinetics of paints, coatings, and slurries; starch pasting cells, namely, test chambers for analyzing starches, dynamic mechanical analysis accessories, namely, accessories for analyzing material properties of solid materials, refrigerated cooling systems, namely, analytical instrument accessories for controlling sample temperature, laboratory instruments, namely, autosamplers and automated sample processing apparatus and carousels, forced convection oven accessories, namely, analytical instrument accessories for controlling sample temperature, orthogonal superposition accessories, namely, accessories for analyzing nonlinear viscoelasticity, 2-dimensional small amplitude oscillatory shear accessories, namely, accessories for analyzing nonlinear viscoelasticity, extensional viscosity fixture accessories, namely, accessories for analyzing extensional viscosity and stress, cone and partitioned plate accessories, namely, accessories for analyzing elastic materials, interfacial rheology accessories, degassing stations, namely, instruments for removing gasses from samples, clamps for use with analytical instruments, evacuated ampoules made of glass, metal, or plastic for use in testing and analyzing samples for non-medical purposes, sample measuring system accessories, namely, accessories for measuring the mechanical and material properties of samples, temperature, pressure, motion, distances, force, torque, viscosity, elasticity, material strain, tension, deflection, compression Providing facilities for scientific research in the nature of a laboratory for the separation sciences; providing facilities for scientific research in the nature of a laboratory featuring instruments for chromatography, mass spectrometry, and material science; consulting services in the field of laboratory research for chemistry, biochemistry, pharmaceutical science, material science, and material characterization; consulting services in the field of laboratory science; technical consulting services in best practices for laboratory research in the field of chemistry, biochemistry pharmaceutical science, material science and material characterization; Scientific research and development; laboratory study and research in the fields of chemistry, biochemistry, pharmaceutical science, material science, and material characterization; scientific laboratory research services in the field of chemistry, biochemistry pharmaceutical science, material science and material characterization; research and development of laboratory instruments in the field of chemistry, biochemistry pharmaceutical science, material science, and material characterization; advisory services relating to the fields of development of laboratory instruments in the field of chemistry, biochemistry pharmaceutical science, material science, and material characterization advisory services related to material testing; Updating, repair, and maintenance of laboratory software; Technical support services, namely, providing information, consultation and diagnostic services in the fields of electronic and optical components, computer software, and scientific, electronic test, measurement, biological and chemical analytical, and optical equipment; services for updating and maintenance of laboratory instrument and laboratory management computer software; technical support services, namely, troubleshooting of laboratory computer software problems; technical support services, namely, operational qualification services for scientific analytical apparatus and instruments, specifically, technical verification and validation of laboratory equipment; providing technical advice relating to use, operation, and function of scientific analytical apparatus and instruments; software as a service (SAAS) services featuring software for analyzing materials by measuring changes in the physical or chemical properties of the material as the material is subjected to controlled changes in its environment software as a service (SAAS) services featuring software for analyzing samples for compliance with environmental regulations; software as a service (SAAS) services featuring software for analyzing samples for toxins or contaminants; software as a service (SAAS) services featuring software for automating chromatography and mass spectrometry operations in a chromatography and mass spectrometry apparatus; software as a service (SAAS) services featuring software for automating laboratory instruments; software as a service (SAAS) services featuring software for automating pipetting; software as a service (SAAS) services featuring software for calibrating pipettes; software as a service (SAAS) services featuring software for collecting, analyzing, organizing, storing, and reporting data for use in scientific analysis; software as a service (SAAS) services featuring software for collecting, analyzing, organizing, storing, and reporting chromatography and mass spectrometry data; software as a service (SAAS) services featuring software for collecting, analyzing, organizing, storing, and reporting data from analytical equipment in the chemical, pharmaceutical, life sciences, environmental, clinical diagnostic, food science and safety, and forensic toxicology fields; software as a service (SAAS) services featuring software for controlling chromatography and spectrometry instruments; software as a service (SAAS) services featuring software for controlling laboratory instruments; software as a service (SAAS) services featuring software for creating and executing laboratory methods and protocols; software as a service (SAAS) services featuring software for data analysis for laboratory instruments and laboratory data; software as a service (SAAS) services featuring software for facilitating laboratory compliance with government regulation; software as a service (SAAS) services featuring software for identifying and analyzing the components of a sample; software as a service (SAAS) services featuring software for laboratory analytical method development, testing, and validation management, namely, for creating, testing, and validating methods for using analytical instruments for laboratory use; software as a service (SAAS) services featuring software for laboratory and laboratory sample management; software as a service (SAAS) services featuring software for laboratory informatics; software as a service (SAAS) services featuring software for laboratory robot control; software as a service (SAAS) services featuring software for laboratory, scientific, and clinical use, namely, computer software for use in managing laboratory operations and analyzing laboratory samples; software as a service (SAAS) services featuring software for managing laboratory workflow, namely, software for controlling, organizing, and tracking laboratory testing projects, laboratory test results, laboratory staff utilization, and reagent and sample inventories; software as a service (SAAS) services featuring software for operating laboratory instruments; software as a service (SAAS) services featuring software for purification of samples in chromatography and spectrometry applications; software as a service (SAAS) services featuring software for use in connection with light scattering and refractive index detection, data acquisition applications, and liquid chromatographic separations; software as a service (SAAS) services featuring software for validating pipette performance; software as a service (SAAS) services featuring software for validating processes in chromatography and mass spectrometry laboratories; software as a service (SAAS) services featuring software for validating processes in laboratories; providing online, non-downloadable software for analyzing materials by measuring changes in the physical or chemical properties of the material as the material is subjected to controlled changes in its environment; providing online, non-downloadable software for analyzing samples for compliance with environmental regulations; providing online, non-downloadable software for analyzing samples for toxins or contaminants; providing online, non-downloadable software for automating chromatography and mass spectrometry operations in a chromatography and mass spectrometry apparatus; providing online, non-downloadable software for automating laboratory instruments; providing online, non-downloadable software for automating pipetting; providing online, non-downloadable software for calibrating pipettes; providing online, non-downloadable software for collecting, analyzing, organizing, storing, and reporting data for use in scientific analysis; providing online, non-downloadable software for collecting, analyzing, organizing, storing, and reporting chromatography and mass spectrometry data; providing online, non-downloadable software for collecting, analyzing, organizing, storing, and reporting data from analytical equipment in the chemical, pharmaceutical, life sciences, environmental, clinical diagnostic, food science and safety, and forensic toxicology fields; providing online, non-downloadable software for controlling chromatography and spectrometry instruments; providing online, non-downloadable software for controlling laboratory instruments; providing online, non-downloadable software for creating and executing laboratory methods and protocols; providing online, non-downloadable software for data analysis for laboratory instruments and laboratory data; providing online, non-downloadable software for facilitating laboratory compliance with government regulation; providing online, non-downloadable software for identifying and analyzing the components of a sample; providing online, non-downloadable software for laboratory analytical method development, testing, and validation management, namely, for creating, testing, and validating methods for using analytical instruments for laboratory use; providing online, non-downloadable software for laboratory and laboratory sample management; providing online, non-downloadable software for laboratory informatics; providing online, non-downloadable software for laboratory robot control; providing online, non-downloadable software for laboratory, scientific, and clinical use, namely, computer software for use in managing laboratory operations and analyzing laboratory samples; providing online, non-downloadable software for managing laboratory workflow, namely, software for controlling, organizing, and tracking laboratory testing projects, laboratory test results, laboratory staff utilization, and reagent and sample inventories; providing online, non-downloadable software for operating laboratory instruments; providing online, non-downloadable software for purification of samples in chromatography and spectrometry applications; providing online, non-downloadable software for use in connection with light scattering and refractive index detection, data acquisition applications, and liquid chromatographic separations; providing online, non-downloadable software for validating pipette performance; providing online, non-downloadable software for validating processes in chromatography and mass spectrometry laboratories; providing online, non-downloadable software for validating processes in laboratories; design and development of analytical apparatus and instruments and parts therefor for scientific and research use; design and development of chemistry consumables for laboratory use; design and development of computer software for analytical apparatus and instruments or scientific and research use; scientific consulting services in the field of analytical chemistry; scientific consulting services in the field of analytical chemistry in the nature of product qualification and validation, implementation project management of scientific research for chemical analyses, computer software testing for chemical analyses, laboratory analytics, and informatics for chemical analyses; scientific consulting in the field of analytical chemistry, namely, development of practical applications and usage of laboratory apparatus and instruments for use in research in analytical chemistry; cloud computing featuring software and software as a service featuring software for use with analytical apparatus and instruments in bioinformatics, laboratory data analysis, analysis and visualization of data from liquid chromatography and mass spectrometry instruments, discovery, identification, and analysis of chemical compounds, analyzing materials by measuring changes in the physical or chemical properties of the material as the material is subjected to controlled changes in its environment; maintenance and repair services for database systems and computer operating software
9.
METHODS AND KITS FOR ELUTING ANALYTES FROM IMMUNOAFFINITY COLUMNS
The present technology provides a method of eluting an analyte of interest from an immunoaffinity column. The methods of the present technology provide a simplified method for disassociating a bound analyte from the immunoaffinity column and allows for direct downstream processing of the eluate.
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded or downloadable software for collecting, analyzing, storing, and reporting chromatography instrument utilization data; Recorded or downloadable software for laboratory asset management, laboratory resource management, laboratory workflow management and analysis, analysis of utilization of laboratory instruments; Recorded or downloadable software for validating laboratory processes
11.
METHODS AND KITS FOR ELUTING ANALYTES FROM IMMUNOAFFINITY COLUMNS
The present technology provides a method of eluting an analyte of interest from an immunoaffinity column. The methods of the present technology provide a simplified method for disassociating a bound analyte from the immunoaffinity column and allows for direct downstream processing of the eluate.
The present disclosure discusses a method of separating a sample (e.g., small organic acid metabolite) including coating a flow path of a chromatographic system. The coating along the flow path is vapor deposited and prevents or severely decreases metal interactions between the metallic chromatographic system and the sample.
An apparatus for performing electrical and rheology measurements of a material sample, comprises a first plate; a second plate; a rotatable drive shaft extending from a motor to rotate the first plate relative to the second plate; and a sample gap between the first plate and the second plate. The second plate includes first and second electrodes that receive a voltage and form an electric field at the sample gap.
G01N 11/14 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane
G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
G01N 27/06 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
14.
RHEOMETER FOR SIMULTANEOUS RHEOLOGICAL AND ELECTRICAL MEASUREMENTS
Described is an apparatus for measuring rheological and electrical properties of a sample. The apparatus includes a first geometry comprising a first and a second stationary element each being electrically conductive and having a surface disposed to face the surface of the other stationary element across a gap. The first and second stationary elements are electrically isolated from each other. The apparatus further includes a second geometry comprising a rotatable element disposed in the gap and configured to rotate between the first and second stationary elements. The rotatable element is electrically conductive such that a first electric field is generated between the first stationary element and the rotatable element and a second electric field is generated between the rotatable element and the second stationary element in response to application of a voltage difference applied across the first and second stationary elements.
G01N 11/14 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane
The present disclosure pertains to sample preparation devices useful for affinity capture and purification that include one or more internal structures that comprise a reservoir, a well, a fluid passageway, sorbent particles, and a filter element that blocks passage of the affinity sorbent particles, which sample preparation devices combine the attributes of both dispersive and flow through designs into a single sample preparation device. The present disclosure also pertains to kits that contain and methods that use such sample preparation devices.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01D 15/12 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
The present technology is directed to methods of improved nucleic acid-based ion-exchange chromatography. In particular, the methods utilize a modification of a sample, and in some examples a modification of mobile phase carrying the sample to the ion-exchange column. In a method of the technology, a bracketed sample is loaded into an injector needle apparatus and injected into an ion-exchange column. The bracketed sample is loaded by (a) adding a first-plug solvent comprising a first salt and having a basic pH; (b) adding a sample plug; and (c) adding a second-plug solvent comprising a second salt and having a basic pH. In certain examples, the bracketed sample is delivered to the column using a mobile phase gradient consisting of first solvent and second solvent and wherein 0% of the second solvent is excluded from the gradient.
The present technology provides a description of a flow column dampener device capable of decreasing the MALS noise from solvent contaminants and transient ripples induced by the HPLC pump prior to the evaluation and characterization of the biophysical properties of macromolecules. This dampener typically includes a particle bed column that can trap and remove the noise-inducing soluble particulates from mobile phase, while simultaneously dampening the noise induced by pump-induced ripples. The types of sorbents, sorbent particle size range and column size formats of the device provides significant reduction in MALS noise prior to the evaluation. This device enables confident characterization of cell and gene therapy products with accurate measurements of the physical properties of the macromolecule analytes such as cell and gene therapy products.
In various aspects, the present disclosure pertains to sorbents for isolating at least one target protein from a liquid sample, the sorbents comprising a solid support comprising attached at least one attached high affinity reagent with an affinity for the at least one target protein. Other aspects of the present disclosure include kit that contain such sorbents and methods of treating samples using the same.
The present technology is directed to a method and kit for extracting oligonucleotides using solid phase extraction. Oligonucleotides are extracted from a biological sample by using a protease-assisted sample pretreatment step and a subsequent weak anion exchange solid phase extraction process.
The present technology is directed to a method and kit for extracting oligonucleotides using solid phase extraction. Oligonucleotides are extracted from a biological sample by using a protease-assisted sample pretreatment step and a subsequent weak anion exchange solid phase extraction process.
A device for sealing to a chromatographic column includes an insertion body and a tip assembly. The insertion body has an attachment end, a tip opposite to the attachment end and a fluidic channel extending between the attachment end and the tip. An attachment feature located near the attachment end secures the insertion body to an actuator. An axially movable sheath may be provided at the tip to protect the tip assembly prior to and during coupling to a column end nut and to assist in aligning the device to the column end nut. The device can be loaded by manual clamping or by an automated clamp mechanism to achieve sufficient force for a fluid tight seal in the column end nut. Devices are column agnostic and may be used in a column oven to enable a chromatography system to be quickly configured with a wide variety of columns.
A device for sealing to a chromatographic column includes an insertion body and a tip assembly. The insertion body has an attachment end, a tip opposite to the attachment end and a fluidic channel extending between the attachment end and the tip. An attachment feature located near the attachment end secures the insertion body to an actuator. An axially movable sheath may be provided at the tip to protect the tip assembly prior to and during coupling to a column end nut and to assist in aligning the device to the column end nut. The device can be loaded by manual clamping or by an automated clamp mechanism to achieve sufficient force for a fluid tight seal in the column end nut. Devices are column agnostic and may be used in a column oven to enable a chromatography system to be quickly configured with a wide variety of columns.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
23.
POROUS MATERIALS WITH CONTROLLED POROSITY; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The chromatographic materials of the invention have controlled porosity and comprise a chromatographic core material and one or more layers of chromatographic surface materials which each independently provide an average pore diameter, an average pore volume, or a specific surface area such that the combined layers form a chromatographic material having a predetermined or desired pattern of porosity from the core material to the outermost surface. The materials are useful for HPLC separations, normal-phase separations, reversed-phase separations, chiral separations, HILIC separations, SFC separations, affinity separations, perfusive separations, partially perfusive separations, and SEC separations.
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A device for unsealing a sample pan for a thermal analysis instrument includes a sample pan holder, an actuator element and a punch element. The sample pan holder is configured to secure the sample pan in a fixed position with respect to the sample pan holder. The actuator element is secured to the sample pan holder and is formed of a thermally sensitive material that changes the shape of the actuator element in response to a change in an external temperature to a transition temperature. The punch element is attached to the actuator element and is positioned with respect to the sample pan such that the change in the shape of the actuator element in response to the change in the external temperature moves the punch element to puncture the sealing element to thereby expose the internal volume of the sample pan to an external environment.
G01N 25/48 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
25.
HERMETICALLY SEALED SAMPLE PAN AND DEVICE FOR UNSEALING SAME
A device (140; 170) for unsealing a sample pan (130) for a thermal analysis instrument includes a sample pan holder, an actuator element and a punch element (144; 174). The sample pan holder is configured to secure the sample pan (130) in a fixed position with respect to the sample pan holder. The actuator element is secured to the sample pan holder and is formed of a thermally sensitive material that changes the shape of the actuator element in response to a change in an external temperature to a transition temperature. The punch element (144; 174) is attached to the actuator element and is positioned with respect to the sample pan (130) such that the change in the shape of the actuator element in response to the change in the external temperature moves the punch element (144; 174) to puncture a sealing element (138) on the sample pan (130) to thereby expose the internal volume of the sample pan (130) to an external environment.
G01N 1/44 - Sample treatment involving radiation, e.g. heat
G01N 25/48 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
F16K 99/00 - Subject matter not provided for in other groups of this subclass
G01N 5/04 - Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid by removing a component, e.g. by evaporation, and weighing the remainder
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Analytical equipment and instruments, namely, mass spectrometry apparatuses for laboratory use; analytical equipment and instruments, namely, mass spectrometry apparatuses for laboratory use, for performing biological and chemical separations, purification, screening and identification for medical laboratory, clinical laboratory, and scientific laboratory use and replacement parts therefor; mass spectrometers for laboratory use; mass spectrometry instruments for laboratory use in connection with chromatography apparatus and instruments; spectrometry apparatus for laboratory use and replacement parts therefor; mass spectrometric apparatus and instruments for laboratory use, namely, ion generators, ion detectors, drift tubes being parts of particle accelerators, and flow-based analyzers for particle analysis; downloadable or recorded operating software for mass spectrometry instruments; recorded or downloadable computer software for operating, configuring, troubleshooting, and controlling laboratory instruments; recorded or downloadable computer software for collecting, manipulating, analyzing, storing, and reporting data in mass spectrometry or liquid chromatography applications; recorded or downloadable computer software for automating and managing laboratory workflows; recorded or downloadable computer software for analyzing laboratory sample properties; mass spectrometric apparatus and instruments, namely, ion generators, ion detectors, drift tubes being parts of particle accelerators, and flow-based analyzers for particle analysis and operating software for use therewith.
(2) Analytical equipment and instruments, namely, mass spectrometry apparatuses for clinical diagnostic use; analytical equipment and instruments, namely, mass spectrometry apparatuses for clinical diagnostic use, for performing biological and chemical separations, purification, screening and identification for medical laboratory, clinical laboratory, and scientific laboratory use and replacement parts therefor; mass spectrometers for clinical diagnostic use; mass spectrometry instruments for clinical diagnostic use in connection with chromatography apparatus and instruments; spectrometry apparatus for clinical diagnostic use and replacement parts therefor; mass spectrometric apparatus and instruments for clinical diagnostic use, namely, ion generators, ion detectors, drift tubes being parts of particle accelerators, and flow-based analyzers for particle analysis; medical apparatus and instrument for clinical diagnostic use, namely, mass spectrometry and chromatography apparatuses and instruments; medical apparatus and instrument for diagnostic use, namely, apparatus for medical diagnostic testing in the fields of bioanalysis, forensic, toxicology analysis, cancer, disease, medical conditions or other tissue-based diagnostic testing, cytology and cell-based testing; medical and clinical diagnostic apparatus for the analysis of pharmaceutical drugs and composition; in vitro diagnostic medical apparatus in the nature of mass spectrometers and chromatography apparatus and instruments for use in medical and laboratory facilities.
27.
PROTEIN A/G PARTICLES FOR AFFINITY CHROMATOGRAPHY AND METHODS OF USE THEREOF
The present disclosure is directed to nonporous polymer particles having an average particle size of 1 to 10 micrometers and being functionalized with an immunoglobulin-binding protein. The functionalized particles of the present disclosure can be used to purify a range of immunoglobulins with affinity to the immunoglobulin-binding protein.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01D 15/08 - Selective adsorption, e.g. chromatography
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
The present disclosure is directed to nonporous polymer particles having an average particle size of 1 to 10 micrometers and being functionalized with an immunoglobulin-binding protein. The functionalized particles of the present disclosure can be used to purify a range of immunoglobulins with affinity to the immunoglobulin-binding protein.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
29.
SYSTEM AND METHOD FOR SOLVENT MIXING IN A CHROMATOGRAPHY SYSTEM
A solvent mixing system includes a mixing tee, a centrifugal mixing path, and a low frequency blending mixer. The mixing tee has at least two solvent input ports and a solvent output port in fluid communication with one another. The centrifugal mixing path has a mixing path inlet in fluid communication with the solvent output port of the mixing tee. The centrifugal mixing path includes at least one coiled segment between the mixing path inlet and a mixing path outlet. The low frequency blending mixer is in fluid communication with the outlet of the centrifugal mixing path.
The present disclosure is directed to nonporous polymer particles having an average particle size of 1 to 10 micrometers and being functionalized with streptavidin. The streptavidin functionalized particles of the present disclosure can be bound to biotinylated antibodies, biotinylated antigen-binding fragments thereof, or biotinylated oligonucleotides to create customizable affinity chromatography columns. That is, the functionalized nonporous polymer particles can be packed in a stainless steel, titanium, or other metal or metal alloy column for affinity high pressure liquid chromatography (HPLC).
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The present technology is directed to methods of preparing affinity chromatographic columns using streptavidin-conjugated particles and biotinylated affinity agents (i.e., biotinylated oligonucleotides, biotinylated antibodies or biotinylated antigen-binding fragments thereof). The methods of the present technology can be utilized to perform affinity capture assays in a high-throughput, efficient manner. Further, the affinity chromatographic columns disclosed herein are customizable due to the ability to utilize any biotinylated affinity agent. The methods herein utilize an on-line loading (i.e., loading the column with biotinylated affinity agent via a liquid chromatography system).
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
The present technology is directed to methods of preparing affinity chromatographic columns using streptavidin-conjugated particles and biotinylated affinity agents (i.e., biotinylated oligonucleotides, biotinylated antibodies or biotinylated antigen-binding fragments thereof). The methods of the present technology can be utilized to perform affinity capture assays in a high-throughput, efficient manner. Further, the affinity chromatographic columns disclosed herein are customizable due to the ability to utilize any biotinylated affinity agent. The methods herein utilize an on-line loading (i.e., loading the column with biotinylated affinity agent via a liquid chromatography system).
The present disclosure is directed to nonporous polymer particles having an average particle size of 1 to 10 micrometers and being functionalized with streptavidin. The streptavidin functionalized particles of the present disclosure can be bound to biotinylated antibodies, biotinylated antigen-binding fragments thereof, or biotinylated oligonucleotides to create customizable affinity chromatography columns. That is, the functionalized nonporous polymer particles can be packed in a stainless steel, titanium, or other metal or metal alloy column for affinity high pressure liquid chromatography (HPLC).
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
Embodiments described herein relate to improved devices and techniques for measuring the charge carried by analyte particles. The charge may be measured in a way that does not destroy the analyte, so that the analyte remains available for further analysis. The charged analyte particles may pass through (or by) an electrode. In doing so, they induce a counter charge on that electrode which can be detected electronically. Subsequent to their passage through that electrode, the particles can be collected on a substrate or may pass in real-time into a mass spectrometer. In some embodiments, both conventional destructive detection and nondestructive detection may both be present in an improved charged aerosol detector and the stream of charged particles may be directed to one or the other by a suitable redirector. Embodiments may be combined with light scattering analysis to provide further non-destructive analysis. Various combinations of these improvements are also described.
Embodiments described herein relate to improved devices and techniques for measuring the charge carried by analyte particles. The charge may be measured in a way that does not destroy the analyte, so that the analyte remains available for further analysis. The charged analyte particles may pass through (or by) an electrode. In doing so, they induce a counter charge on that electrode which can be detected electronically. Subsequent to their passage through that electrode, the particles can be collected on a substrate or may pass in real-time into a mass spectrometer. In some embodiments, both conventional destructive detection and nondestructive detection may both be present in an improved charged aerosol detector and the stream of charged particles may be directed to one or the other by a suitable redirector. Embodiments may be combined with light scattering analysis to provide further non-destructive analysis. Various combinations of these improvements are also described.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Recorded software for data monitoring software for
chromatography and spectrometry instruments; recorded
software for collecting, monitoring, sorting, updating, and
reporting data in chromatography and mass spectrometry
applications; recorded computer software for managing
laboratory workflow, namely, software for monitoring,
organizing, and tracking laboratory testing projects, sample
running status, estimated running time, reporting laboratory
test results; recorded software for monitoring laboratory
analytical testing, namely, for monitoring sample testing
process and status for using analytical instruments for
laboratory use; recorded software for laboratory and sample
data monitoring. Software as a service (SAAS) services featuring data
monitoring software for chromatography and spectrometry
instruments; software as a service (SAAS) services featuring
software for collecting, monitoring, storing, updating, and
reporting data in chromatography and mass spectrometry
applications; software as a service (SAAS) services
featuring software for monitoring laboratory analytical
testing, namely, for monitoring sample testing process and
status for using analytical instruments for laboratory use;
software as a service (SAAS) services featuring software for
monitoring validating processes in a chromatography and mass
spectrometry laboratories; software as a service (SAAS)
services featuring software for laboratory and sample data
monitoring.
37.
COATINGS WITH IMMOBILIZED AFFINITY LIGANDS AND ENZYMES AND USE THEREOF IN LIQUID CHROMATOGRAPHY ASSAYS
A sample preparation device is provided for enriching a component of a sample. The sample preparation device includes a surface in fluid communication with the sample, an alkylsilyl coating disposed on the surface, and an affinity ligand or an enzyme covalently bonded to the alkylsilyl coating.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
38.
SORBENT USED TO IMPROVE CHROMATOGRAPHIC SEPARATIONS IN SIZE EXCLUSION CHROMATOGRAPHY VIA REDUCED SECONDARY INTERACTIONS
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A bottle cap includes a lower cap body that is threaded for attachment about an opening in a solvent bottle and an upper cap body attached to the lower cap body. A liner disposed inside the lower cap body includes at least one opening to pass a solvent tube while limiting evaporation of the solvent in the bottle. Features in the upper cap body permit identification flags to be attached. Each flag has an opening to pass a corresponding tube and includes one or more characters or symbols, color-coding and/or shape-coding to identify the corresponding solvent and/or a system inlet to which the tube is connected at its other end. The upper and lower cap bodies are independently rotatable about a cap axis and allow the bottle cap to be removed from or attached to the bottle without the need to remove any tubes passing through the bottle cap.
A bottle cap includes a lower cap body that is threaded for attachment about an opening in a solvent bottle and an upper cap body attached to the lower cap body. A liner disposed inside the lower cap body includes at least one opening to pass a solvent tube while limiting evaporation of the solvent in the bottle. Features in the upper cap body permit identification flags to be attached. Each flag has an opening to pass a corresponding tube and includes one or more characters or symbols, color-coding and/or shape-coding to identify the corresponding solvent and/or a system inlet to which the tube is connected at its other end. The upper and lower cap bodies are independently rotatable about a cap axis and allow the bottle cap to be removed from or attached to the bottle without the need to remove any tubes passing through the bottle cap.
B65D 51/24 - Closures not otherwise provided for combined with auxiliary devices for non-closing purposes
B65D 41/04 - Threaded or like caps or cap-like covers secured by rotation
42.
IMPROVING THE ANALYSIS OF OLIGOSACCHARIDES USING A LIQUID CHROMATOGRAPHY SYSTEM AND A CHROMATOGRAPHIC COLUMN IN WHICH THE LC SYSTEM AND COLUMN'S INTERNAL METAL SURFACE HAS BEEN MODIFIED WITH A LAYER OF INERT MATERIAL
The present disclosure is directed to methods of separating one or more non-modified oligosaccharide(s) with degree of polymerization 6 or higher from a sample using a hydrophilic interaction liquid chromatography (HILIC) column connected to a liquid chromatography system that includes coated flow paths. The methods disclosed herein requires, inter alia, a liquid chromatography system, wherein at least one component of the LC system includes a fluid-contacting alkylsilyl coating. When implementing a standard HILIC method, the methods of the present technology can be used to decrease the analyte loss and/or carry-over of the separation leading to improved analysis.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. The method includes introducing a sample comprising the analytes into a chromatographic system. The chromatographic system has a flow path disposed in an interior of the chromatographic system, at least a portion of the flow path having an active coating, and a chromatographic column having a stationary phase material in an interior of the chromatographic column that facilitates separation of the analytes in the sample through interaction with at least one analyte in the sample. The active coating is selected to interact with at least one analyte in the sample through (1) a repulsive force, (2) a secondary interaction, or (3) a retention mechanism distinct from the interaction with the stationary phase material.
G01N 30/26 - Conditioning of the fluid carrierFlow patterns
B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
Threaded conventional column end fittings for liquid chromatography columns do not have face seals that enable them to be used with clamping fluidic connectors. The exemplary embodiments may provide adapters that interface with conventional threaded column end fittings so that the column assembly may now be used with the clamping fluidic connectors. The adapters of the exemplary embodiments may include lock nuts for securing the adapters to column end fittings of a liquid chromatography columns. The lock nuts may include threads that bear the load of the adapter rather than the column end fitting of the chromatography column. The threads of the lock nut become the load bearing surfaces, and the load is distributed over the surfaces where the threads of the adapter engage with the threads of the lock nut.
Threaded conventional column end fittings for liquid chromatography columns do not have face seals that enable them to be used with clamping fluidic connectors. The exemplary embodiments may provide adapters that interface with conventional threaded column end fittings so that the column assembly may now be used with the clamping fluidic connectors. The adapters of the exemplary embodiments may include lock nuts for securing the adapters to column end fittings of a liquid chromatography columns. The lock nuts may include threads that bear the load of the adapter rather than the column end fitting of the chromatography column. The threads of the lock nut become the load bearing surfaces, and the load is distributed over the surfaces where the threads of the adapter engage with the threads of the lock nut.
B01D 15/10 - Selective adsorption, e.g. chromatography characterised by constructional or operational features
F16L 19/00 - Joints in which sealing surfaces are pressed together by means of a member, e.g. a swivel nut, screwed on, or into, one of the joint parts
ANALYSIS OF OLIGOSACCHARIDES USING A LIQUID CHROMATOGRAPHY SYSTEM AND A CHROMATOGRAPHIC COLUMN IN WHICH THE LC SYSTEM AND COLUMN'S INTERNAL METAL SURFACE HAS BEEN MODIFIED WITH A LAYER OF INERT MATERIAL
The present disclosure is directed to methods of separating one or more non-modified oligosaccharide(s) with degree of polymerization 6 or higher from a sample using a hydrophilic interaction liquid chromatography (HILIC) column connected to a liquid chromatography system that includes coated flow paths. The methods disclosed herein requires, inter alia, a liquid chromatography system, wherein at least one component of the LC system includes a fluid-contacting alkylsilyl coating. When implementing a standard HILIC method, the methods of the present technology can be used to decrease the analyte loss and/or carry-over of the separation leading to improved analysis.
The current invention provides a novel method to synthesize a mono-disperse non-porous polymer particles with a unique gradient composition from the core to the shell. In particular, the present invention offers the flexibility to design the chemical and physical properties of different sections of the particle. This flexibility allows for significant latitude in the design of particles for analyzing a large variety of samples in different fields—through using these particles in different chromatography techniques including, but not limited to, ion exchange HPLC (e.g., bio-separation at different modes), reversed-phase HPLC, narrow bore and capillary HPLC, hydrophilic/hydrophobic interaction liquid chromatography, capillary electrochromatography separation, and two dimensional liquid chromatography.
In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
B01D 15/40 - Selective adsorption, e.g. chromatography characterised by the separation mechanism using supercritical fluid as mobile phase or eluent
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded or downloadable operating and data analysis software for material testing laboratory instruments; recorded or downloadable software for collecting, analyzing, storing, and reporting data in material testing applications; recorded or downloadable software for collecting, analyzing, storing, and reporting viscosity measurement data; recorded or downloadable software for collecting, analyzing, storing, and reporting data for use in scientific analysis; recorded or downloadable software for laboratory informatics; recorded or downloadable software for laboratory instrument control; recorded and downloadable computer software for managing laboratory workflow, namely, software for controlling, organizing, and tracking laboratory testing projects and experiments, laboratory test results, and reagent and sample inventories; recorded or downloadable computer software for validating processes for material testing laboratories; recorded or downloadable software for facilitating laboratory compliance with government regulation; recorded or downloadable computer software programs used to collect, organize, analyze, and manage data from analytical equipment in the fields of chemicals, pharmaceuticals, polymers, adhesives, sealants, batteries, battery materials, personal care products, household products, agricultural chemicals, food products, asphalt paving materials, paints, inks, and coatings; recorded or downloadable software for laboratory and sample management; recorded or downloadable operating software for touch screen display units for laboratory instruments; recorded or downloadable software for monitoring and controlling quality control of analytical equipment in laboratories.
51.
CHELATOR BASED ELUENTS FOR SOLID PHASE EXTRACTION OF PHOSPHORYLATED COMPOUNDS
The present technology relates to a method for improved recovery of phosphorylated compounds (e.g., phosphorylated glycans). In particular, the present technology utilizes certain chelator additives in a solution to wash and elute the phosphorylated compounds from a solid phase extraction cartridge.
B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/281 - Sorbents specially adapted for preparative, analytical or investigative chromatography
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Analytical equipment and instruments, namely, mass
spectrometry apparatuses for laboratory use; analytical
equipment and instruments, namely, mass spectrometry
apparatuses for laboratory use, for performing biological
and chemical separations, purification, screening and
identification for medical laboratory, clinical laboratory,
and scientific laboratory use and replacement parts
therefor; mass spectrometers for laboratory use; mass
spectrometry instruments for laboratory use in connection
with chromatography apparatus and instruments; spectrometry
apparatus for laboratory use and replacement parts therefor;
mass spectrometric apparatus and instruments for laboratory
use, namely, ion generators, ion detectors, drift tubes
being parts of particle accelerators, and flow-based
analyzers for particle analysis; downloadable or recorded
operating software for mass spectrometry instruments;
recorded or downloadable computer software for operating,
configuring, troubleshooting, and controlling laboratory
instruments; recorded or downloadable computer software for
collecting, manipulating, analyzing, storing, and reporting
data in mass spectrometry or liquid chromatography
applications; recorded or downloadable computer software for
automating and managing laboratory workflows; recorded or
downloadable computer software for analyzing laboratory
sample properties; mass spectrometric apparatus and
instruments, namely, ion generators, ion detectors, drift
tubes being parts of particle accelerators, and flow-based
analyzers for particle analysis and operating software for
use therewith. Analytical equipment and instruments, namely, mass
spectrometry apparatuses for clinical diagnostic use;
analytical equipment and instruments, namely, mass
spectrometry apparatuses for clinical diagnostic use, for
performing biological and chemical separations,
purification, screening and identification for medical
laboratory, clinical laboratory, and scientific laboratory
use and replacement parts therefor; mass spectrometers for
clinical diagnostic use; mass spectrometry instruments for
clinical diagnostic use in connection with chromatography
apparatus and instruments; spectrometry apparatus for
clinical diagnostic use and replacement parts therefor; mass
spectrometric apparatus and instruments for clinical
diagnostic use, namely, ion generators, ion detectors, drift
tubes being parts of particle accelerators, and flow-based
analyzers for particle analysis; medical apparatus and
instrument for clinical diagnostic use, namely, mass
spectrometry and chromatography apparatuses and instruments;
medical apparatus and instrument for diagnostic use, namely,
apparatus for medical diagnostic testing in the fields of
bioanalysis, forensic, toxicology analysis, cancer, disease,
medical conditions or other tissue-based diagnostic testing,
cytology and cell-based testing; medical and clinical
diagnostic apparatus for the analysis of pharmaceutical
drugs and composition; in vitro diagnostic medical apparatus
in the nature of mass spectrometers and chromatography
apparatus and instruments for use in medical and laboratory
facilities.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
Silica-based chromatographic packing media; Silica-based chromatographic packing media for use in connection with analytical liquid chromatography. Chromatography columns for use in connection with liquid chromatography and mass spectrometry instruments; Scientific and chromatographic apparatus and instruments; chromatographic columns for analytical chromatography and incorporated silica based packing materials; parts and fittings for all the aforesaid goods.
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded or downloadable operating and data analysis software for material testing laboratory instruments; recorded or downloadable software for collecting, analyzing, storing, and reporting data in material testing applications; recorded or downloadable software for collecting, analyzing, storing, and reporting viscosity measurement data; recorded or downloadable software for collecting, analyzing, storing, and reporting data for use in scientific analysis; recorded or downloadable software for laboratory informatics; recorded or downloadable software for laboratory instrument control; recorded and downloadable computer software for managing laboratory workflow, namely, software for controlling, organizing, and tracking laboratory testing projects and experiments, laboratory test results, and reagent and sample inventories; recorded or downloadable computer software for validating processes for material testing laboratories; recorded or downloadable software for facilitating laboratory compliance with government regulation; recorded or downloadable computer software programs used to collect, organize, analyze, and manage data from analytical equipment in the fields of chemicals, pharmaceuticals, polymers, adhesives, sealants, batteries, battery materials, personal care products, household products, agricultural chemicals, food products, asphalt paving materials, paints, inks, and coatings; recorded or downloadable software for laboratory and sample management; recorded or downloadable operating software for touch screen display units for laboratory instruments; recorded or downloadable software for monitoring and controlling quality control of analytical equipment in laboratories
A device for holding a chromatography column includes a first clip attachable to the securing rail configured to hold a first end of a chromatography column in a fixed position relative to the securing rail within the space of the securing rail, the first column clip including a body structure and at least one protrusion extending from the body structure that is dimensioned to fit within the at least one channel of the walled structure of the securing rail. The body structure is made of an elastically deformable material configured to be compressed by hand such that the at least one outwardly extending protrusion is insertable into the at least one channel after which the body structure is configured to expand in order to hold the first clip within the walled structure of the securing rail.
A device for holding a chromatography column includes a first clip attachable to the securing rail configured to hold a first end of a chromatography column in a fixed position relative to the securing rail within the space of the securing rail, the first column clip including a body structure and at least one protrusion extending from the body structure that is dimensioned to fit within the at least one channel of the walled structure of the securing rail. The body structure is made of an elastically deformable material configured to be compressed by hand such that the at least one outwardly extending protrusion is insertable into the at least one channel after which the body structure is configured to expand in order to hold the first clip within the walled structure of the securing rail.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition.
G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
B01F 25/00 - Flow mixersMixers for falling materials, e.g. solid particles
Provided herein are compositions, kits and methods that may be useful for improving the efficiency of solid phase extraction to separate oligonucleotides from a complex matrix. Particularly, the present technology relates to a sorbent material including porous particles, the surface of which is modified with a ligand that includes one or more bridging alkyl substituted amines and at least two siloxyl terminal groups.
The present technology relates to a method of separating a sample comprising oligonucleotides. The method includes injecting a polyphosphonic acid at a concentration of between about 0.01 M to about 1 M into the sample comprising oligonucleotides. The method also includes flowing the sample and polyphosphonic acid through a liquid chromatography column and separating the oligonucleotides.
Provided herein are compositions, kits and methods that may be useful for improving the efficiency of solid phase extraction to separate oligonucleotides from a complex matrix. Particularly, the present technology relates to a sorbent material including porous particles, the surface of which is modified with a ligand that includes one or more bridging alkyl substituted amines and at least two siloxyl terminal groups.
B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/30 - Processes for preparing, regenerating or reactivating
G01N 21/33 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
Provided herein is a tubular protein capture device including a continuous tubular body having an inner surface and an outer surface and methods of using thereof for cell clarification purposes. A protein selected from protein A, protein G, protein L or combination thereof is attached to the inner surface of the tubular protein capture device described herein. The devices and methods provided herein are useful for improving the efficiency and/or capacity of cell clarification to separate proteins. In some embodiments, the continuous tubular body of the present technology has a helical shape. In other embodiments, the continuous tubular body of the present technology includes a plurality of tubes aligned within a hollow enclosure.
The present disclosure describes a system for purifying and enriching a sample and methods of making and using thereof. The system has immunoaffinity ligands immobilized on one or more of a three-dimensional porous membrane secured in a device such that the membrane is capable of immunoaffinity binding a target compound when a sample is aspirated or expelled from the device as the sample passes through the membrane.
The present disclosure describes a system for purifying and enriching a sample and methods of making and using thereof. The system has immunoaffinity ligands immobilized on one or more of a three-dimensional porous membrane secured in a device such that the membrane is capable of immunoaffinity binding a target compound when a sample is aspirated or expelled from the device as the sample passes through the membrane.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The present disclosure discusses a method of separating a sample (e.g., pharmaceutical drug, genotoxic impurity, biomarker, and/or biological metabolite) including coating a metallic flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample using mass spectroscopy. In some examples, the coating applied to the surfaces defining the flow path is non-binding with respect to the sample—and the separated sample. Consequently, the sample does not bind to the low-binding surface of the coating of the flow path. The applied coating can increase the chromatographic peak area for the sample of the chromatographic system.
A liquid chromatography sample manager includes a thermal chamber, a sample platter mounted in the thermal chamber, and a needle drive including a base having a shaft configured to rotate about a vertical axis, the base attachable to an interior of a sample manager of a liquid chromatography system. The needle drive further includes a needle assembly attached to the base, the needle assembly including a sample needle, and a drive system attached to the base, the drive system including a sample needle motor configured to impart vertical movement of the sample needle. The liquid chromatography sample manager further includes a sample delivery system configured to transfer a first sample from a first sample vial carrier located in the sample platter into a chromatographic flow stream.
The present disclosure discusses a method of separating a sample including oligonucleotides including coating a flow path of a chromatographic system; injecting the sample comprising oligonucleotides into the chromatographic system; flowing the sample through the chromatographic system; and separating the oligonucleotides. In some examples, the coating of the flow path is non-binding with respect to the analyte, such as oligonucleotides. Consequently, the analyte does not bind to the coating of the flow path. The non-binding coating eliminates the need for passivation, which can eliminate the formerly needed time to passivate as well. In addition, analyte can be recovered with a first injection in a system, such as chromatographic system.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
G01N 30/34 - Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
67.
PRESSED AND MIXED THIN FILM ENZYMATIC REACTOR AND METHODS OF MAKING THE SAME
Disclosed herein are methods and devices for accelerating substrate-enzyme reaction rates for sample preparation in bioprocessing assays using pressed and mixed thin films containing predetermined ratios of a biological substrate, e.g., polypeptide, protein, nucleic acid, sugar, or lipid, and an enzyme.
Disclosed herein are methods and devices for accelerating substrate-enzyme reaction rates for sample preparation in bioprocessing assays using pressed and mixed thin films containing predetermined ratios of a biological substrate, e.g., polypeptide, protein, nucleic acid, sugar, or lipid, and an enzyme.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Analytical equipment and instruments, namely, mass spectrometry apparatuses for laboratory use; Analytical equipment and instruments, namely, mass spectrometry apparatuses for laboratory use, for performing biological and chemical separations, purification, screening and identification for medical laboratory, clinical laboratory, and scientific laboratory use and replacement parts therefor; mass spectrometers for laboratory use; mass spectrometry instruments for laboratory use in connection with chromatography apparatus and instruments; spectrometry apparatus for laboratory use and replacement parts therefor; mass spectrometric apparatus and instruments for laboratory use, namely, ion generators, ion detectors, drift tubes being parts of particle accelerators, and flow-based analyzers for particle analysis; downloadable or recorded operating software for mass spectrometry instruments; Recorded or downloadable computer software for operating, configuring, troubleshooting, and controlling laboratory instruments; Recorded or downloadable computer software for collecting, manipulating, analyzing, storing, and reporting data in mass spectrometry or liquid chromatography applications; Recorded or downloadable Computer software for automating and managing laboratory workflows; Recorded or downloadable Computer software for analyzing laboratory sample properties; mass spectrometric apparatus and instruments, namely, ion generators, ion detectors, drift tubes being parts of particle accelerators, and flow-based analyzers for particle analysis and operating software for use therewith Analytical equipment and instruments, namely, mass spectrometry apparatuses for clinical diagnostic use; Analytical equipment and instruments, namely, mass spectrometry apparatuses for clinical diagnostic use, for performing biological and chemical separations, purification, screening and identification for medical laboratory, clinical laboratory, and scientific laboratory use and replacement parts therefor; mass spectrometers for clinical diagnostic use; mass spectrometry instruments for clinical diagnostic use in connection with chromatography apparatus and instruments; spectrometry apparatus for clinical diagnostic use and replacement parts therefor; mass spectrometric apparatus and instruments for clinical diagnostic use, namely, ion generators, ion detectors, drift tubes being parts of particle accelerators, and flow-based analyzers for particle analysis; medical apparatus and instrument for clinical diagnostic use, namely, mass spectrometry and chromatography apparatuses and instruments; medical apparatus and instrument for diagnostic use, namely, apparatus for medical diagnostic testing in the fields of bioanalysis, forensic, toxicology analysis, cancer, disease, medical conditions or other tissue-based diagnostic testing, cytology and cell-based testing; medical and clinical diagnostic apparatus for the analysis of pharmaceutical drugs and composition; in vitro diagnostic medical apparatus in the nature of mass spectrometers and chromatography apparatus and instruments for use in medical and laboratory facilities
70.
MULTI-COMPONENT SURFACE CHEMISTRY TO ELIMINATE RETENTION LOSS IN REVERSED-PHASE LIQUID CHROMATOGRAPHY
Provided herein is a multi-component chromatographic material and use thereof for reversed-phase liquid chromatography. The multi-component chromatographic materials provided herein comprise a chromatographic core having an exterior surface; and at least two different hydrophobic ligands covalently bound to the exterior surface with a total surface coverage less than 2.0 μmol/m2. The multi-component chromatographic materials of the present technology are beneficial for reversed-phase liquid chromatography using highly aqueous mobile phases. For example, chromatographic materials described herein allow mitigating or preventing significant retention loss of reversed-phase liquid chromatography columns after flow interruption.
The present disclosure describes methods for analyzing mRNA poly(A) tail sequences with a high resolution to determine poly (A) tail length and heterogeneity. The method involves digesting an mRNA molecule to liberate a poly(A) tail, preparing a chromatographic sample comprising the mRNA poly(A) tails, preparing a second chromatographic sample comprising a reference sequence comprising a mRNA poly(A) tails having a predetermined length, separating the first and second samples by a chromatography method, which result in one or more chromatograms, and determining a sequence length of the mRNA poly(A) tails by comparing the chromatograms of the first and second samples. Chromatography methods for analyzing the poly(A) tail may include ultraviolet size-exclusion chromatography (SEC UV), ultraviolet ion-pair reversed-phase liquid chromatography (IP RP EC UV), ultra high performance liquid chromatography (UPHLC), and combinations thereof.
The present disclosure discusses a device and method for improving the reaction rate of enzymatic modification of biopolymers. A thermophoretic device is used to increase the rate of enzymatic reactions with biopolymers by creating a temperature gradient using a heating element and a cooling element. The use of a temperature gradient within a cavity in the thermophoretic device concentrates the reacts along an interior surface of the device, increasing the reaction rate.
The present disclosure discusses a device and method for improving the reaction rate of enzymatic modification of biopolymers. A thermophoretic device is used to increase the rate of enzymatic reactions with biopolymers by creating a temperature gradient using a heating element and a cooling element. The use of a temperature gradient within a cavity in the thermophoretic device concentrates the reacts along an interior surface of the device, increasing the reaction rate.
Provided herein is a multi-component chromatographic material and use thereof for reversed-phase liquid chromatography. The multi-component chromatographic materials provided herein comprise a chromatographic core having an exterior surface; and at least two different hydrophobic ligands covalently bound to the exterior surface with a total surface coverage less than 2.0 μmol/m2. The multi-component chromatographic materials of the present technology are beneficial for reversed-phase liquid chromatography using highly aqueous mobile phases. For example, chromatographic materials described herein allow mitigating or preventing significant retention loss of reversed-phase liquid chromatography columns after flow interruption.
B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The present disclosure describes methods for analyzing mRNA poly(A) tail sequences with a high resolution to determine poly(A) tail length and heterogeneity. The method involves digesting an mRNA molecule to liberate a poly(A) tail, preparing a chromatographic sample comprising the mRNA poly(A) tails, preparing a second chromatographic sample comprising a reference sequence comprising a mRNA poly(A) tails having a predetermined length, separating the first and second samples by a chromatography method, which result in one or more chromatograms, and determining a sequence length of the mRNA poly(A) tails by comparing the chromatograms of the first and second samples. Chromatography methods for analyzing the poly(A) tail may include ultraviolet size-exclusion chromatography (SEC UV), ultraviolet ion-pair reversed-phase liquid chromatography (IP RP LC UV), ultra high performance liquid chromatography (UPHLC), and combinations thereof.
09 - Scientific and electric apparatus and instruments
Goods & Services
Chromatography columns for laboratory use; laboratory instruments for sample preparation, purification, concentration, and collection, namely, chromatography columns; chromatography columns for use with liquid chromatography and mass spectrometry instruments.
77.
PROTEIN CAPTURE FROM RAW CELL CULTURE USING PROTEIN A AFFIXED IN OPEN TUBULAR AND ANNULAR HELICALLY COILED TUBES
Provided herein is a tubular protein capture device including a continuous tubular body having an inner surface and an outer surface and methods of using thereof for cell clarification purposes. A protein selected from protein A, protein G, protein L or combination thereof is attached to the inner surface of the tubular protein capture device described herein. The devices and methods provided herein are useful for improving the efficiency and/or capacity of cell clarification to separate proteins. In some embodiments, the continuous tubular body of the present technology has a helical shape. In other embodiments, the continuous tubular body of the present technology includes a plurality of tubes aligned within a hollow enclosure.
The present disclosure discusses a method of separating and/or purifying polynucleotides. The method includes injecting a sample into cartridge that is packed with a porous sorbent between opposing frits. Physical properties of the cartridge along with the use of hydrophilic frits allows efficient desalting of biopolymers using a vacuum to pull the sample through the cartridge.
Described are systems and methods for image recognition in test systems. A method for safe operation of a test system includes capturing image data representative of a test area of the test system with an imaging device, transmitting the image data representative of the test area from the imaging device to a processor running an image recognition application, detecting, by the image recognition application, a user presence within the test area, and adjusting the test system to a safe mode in response to the detecting the user presence within the test area.
Provided herein is a method and system for PFAS analysis using a liquid chromatography technique that employ a first column (e.g., an isolator column) and a second column (e.g., an analytical column), wherein at least one of the first column, the second column, or both the first and second columns include mixed mode with anion exchange surface chemistry. The devices and methods provided herein are useful for improving the efficiency and/or sensitivity of systems implementing liquid chromatography for PFAS analysis. The methods of the present disclosure are particularly beneficial for trace level (e.g., ppm level or lower) analysis of PFAS. Further, the methods of the present disclosure allow improved separation of short-chain and ultrashort-chain PFAS.
G01N 30/96 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography using ion-exchange
The present disclosure discusses a method of separating and/or purifying polynucleotides. The method includes injecting a sample into cartridge that is packed with a porous sorbent between opposing frits. Physical properties of the cartridge along with the use of hydrophilic fits allows efficient desalting of biopolymers using a vacuum to pull the sample through the cartridge.
Provided herein is a method and system for PFAS analysis using a liquid chromatography technique that employ a first column (e.g., an isolator column) and a second column (e.g., an analytical column), wherein at least one of the first column, the second column, or both the first and second columns include mixed mode with anion exchange surface chemistry. The devices and methods provided herein are useful for improving the efficiency and/or sensitivity of systems implementing liquid chromatography for PFAS analysis. The methods of the present disclosure are particularly beneficial for trace level (e.g., ppm level or lower) analysis of PFAS. Further, the methods of the present disclosure allow improved separation of short-chain and ultrashort-chain PFAS.
G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
83.
HYBRID MATERIAL FOR CHROMATOGRAPHIC SEPARATIONS COMPRISING A SUPERFICIALLY POROUS CORE AND A SURROUNDING MATERIAL
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The preparation of the inorganic/organic hybrid materials of the invention wherein a surrounding material is condensed on a superficially porous hybrid core material will allow for families of different hybrid packing materials to be prepared from a single core hybrid material. Differences in hydrophobicity, ion-exchange capacity, chemical stability, surface charge or silanol activity of the surrounding material may be used for unique chromatographic separations of small molecules, carbohydrates, antibodies, whole proteins, peptides, and/or DNA.
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A linear motor including a stator assembly, an armature mechanically coupleable to a test specimen configured to be moved relative to the stator assembly by operation of the linear motor, and a suspension system configured facilitate movement of the armature relative to the stator assembly along an axis of movement without physically touching the armature during movement. Further disclosed is a multi-phase linear motor, a linear motor having an armature with an array of flat magnets, and a linear motor having a magnetic damping system.
The present technology relates to a method and instrument for classifying a sample. The method collects raw data from an analytical instrument (e.g., LC-MS), quantifies consistency parameters from the raw chromatographic data (e.g., peak detection) by assigning criteria and determining probability ratios, and constructs a learning model quantitation step by weighing the presence, absence, or modulation of one or more factors of the one or more samples against a decision criterion for positivity. The method can then apply the learning model to an unknown sample to detect the presence, absence, or modulation of one or more factors in the unknown sample such as the presence, absence, or modulation of a disease state or multiple disease states.
The present technology relates to a method and instrument for classifying a sample. The method collects raw data from an analytical instrument (e.g., LC-MS), quantifies consistency parameters from the raw chromatographic data (e.g., peak detection) by assigning criteria and determining probability ratios, and constructs a learning model quantitation step by weighing the presence, absence, or modulation of one or more factors of the one or more samples against a decision criterion for positivity. The method can then apply the learning model to an unknown sample to detect the presence, absence, or modulation of one or more factors in the unknown sample such as the presence, absence, or modulation of a disease state or multiple disease states.
The present disclosure pertains to non-porous composite particles that are non-porous, polymer-based particles. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is in contact with the modified surface of the core, and a bonding material is in contact with the non-porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such non-porous composite particles.
C08F 283/06 - Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass on to polyethers, polyoxymethylenes or polyacetals
88.
COMPOSITE PARTICLES WITH NON-POROUS HYBRID ORGANIC-INORGANIC MATERIAL
The present disclosure pertains to composite particles with polymer-based cores, which eliminate the high pH failure mechanism of silica-based core-shell silica particles. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is in contact with the modified surface of the core, and a porous inorganic material is in contact with the non-porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such composite particles.
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The present disclosure pertains to core-shell particles that are superficially porous, polymer-based, and include organic-inorganic materials. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is in contact with the modified surface of the core, and a porous hybrid organic-inorganic material is in contact with the non-porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such core-shell particles.
B01J 20/281 - Sorbents specially adapted for preparative, analytical or investigative chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
This present disclosure relates to engineered protease enzymes, including trypsin, Lys-C and Asp-N proteases, that have enhanced autolysis resistance. Also disclosed herein are methods of using such engineered enzymes for improving detection of target analyte proteins in an analytical assay.
A method is provided for controlling a multi-pole charged particle transmission device having rods spaced apart radially about a central axis extending from a particle inlet at one end of the device to a particle outlet at an opposite end. An AC voltage source is controlled to apply an AC voltage having a frequency, a peak amplitude, and a waveform shape to the charged particle transmission device, and a set of charged particles is passed through the device under such conditions. The AC voltage source is then controlled to change at least one of the frequency, peak amplitude or shape of the AC, and another set of the charged particles is then passed through the charged particle transmission device under such conditions.
The present disclosure pertains to non-porous composite particles that are non-porous, polymer-based, organic-inorganic materials. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is disposed on the modified surface of the core. The present disclosure pertains to chromatographic separation devices that comprise such non-porous composite particles.
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A method is provided for controlling a multi-pole charged particle transmission device having rods spaced apart radially about a central axis extending from a particle inlet at one end of the device to a particle outlet at an opposite end. An AC voltage source is controlled to apply an AC voltage having a frequency, a peak amplitude and a waveform shape to the charged particle transmission device, and a set of charged particles is passed through the device under such conditions. The AC voltage source is then controlled to change at least one of the frequency, peak amplitude or shape of the AC, and another set of the charged particles is then passed through the charged particle transmission device under such conditions.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
Analytical standard solutions and reagents for scientific and research use; analytical standard solutions and reagents for testing soil for the purpose of monitoring contaminants; chromatography chemicals; sample preparation kits for scientific and research purposes, comprising biological standards, namely, monoclonal antibodies, and chemical reagents for biological analysis; chemical reagents for preparing samples for chromatography and mass spectrometry for non-medical, laboratory use; chemicals, namely, buffers and standard solutions used in analytical chemistry; buffers in the nature of chemicals used in analytical chemistry; chemically-treated non-medical test strips and test-strip holders specifically adapted for, and sold with, the aforementioned test strips for the detection of mycotoxins by antibody affinity reactions in grain, feed, and food products; assay kits comprising an affinity chromatography column and chemical reagents for testing for mycotoxin contamination in grain, feed, and food products; environmental quality control fluid, gas, and soil samples for calculating standards for testing and verifying the quality of soil and air A house mark for a full line of analytical apparatus and instruments for laboratory use and their parts, fittings, and accessories therefor; Analytical apparatus and instruments for performing biological testing, physical testing, biological and chemical separation, purification, screening and identification and structural parts and structural fittings therefor, namely, liquid chromatography apparatus and instruments for laboratory use and structural parts and structural fittings therefor, gas chromatography apparatus for laboratory use and structural parts and structural fittings therefor, ion mobility chromatography apparatus for laboratory use and structural parts and structural fittings therefor, mass spectrometry apparatus and instruments for laboratory use and structural parts and structural fittings therefor; analytical apparatus and instruments, namely, detectors for indicating the presence or absence of toxins in the fields of agriculture and food processing and structural parts and structural fittings therefor; analytical apparatus and instruments for laboratory use, namely, magnetic suspension balances and structural parts and structural fittings therefor; analytical apparatus and instruments for laboratory use, namely, mechanical testing instruments, rubber testing instruments and structural parts and structural fittings therefor; scientific analytical apparatus and instruments in the nature of magnetic suspension balances for isothermal measuring equilibrium and kinetics of ad- or absorption processes and for thermogravimetric measurements at high temperatures and high pressures, gravimetric analysis, thermogravimetric analysis or sorption analysis and structural parts and structural fittings therefor; analytical apparatus and instruments for laboratory use for gas and vapor dosing, mixing, and pressure control and structural parts and structural fittings therefor; analytical apparatus and instruments for laboratory use, namely, electrosurgical instruments used with analytical instruments to identify the presence or absence of toxins in sample tissues, electrosurgical smoke evaluation devices, devices for identification of chemicals in electrosurgical smoke for non-medical diagnostic and analytical purposes; fluorometers and structural parts and structural fittings therefor; lateral flow readers and structural parts and structural fittings therefor; rheometers and structural parts and structural fittings therefor; calorimeters and structural parts and structural fittings therefor; dilatometers and structural parts and structural fittings therefor; laboratory chemical reactors; diagnostic apparatus for testing food; diagnostic apparatus for testing agricultural products; diagnostic apparatus for the detection and identification of microbes and pathogens for laboratory or research use; diagnostic apparatus for testing for illegal drugs, diagnostic apparatus for forensic toxicology; chromatography columns for laboratory use; laboratory consumables, namely, vials, containers, sample trays, sample plates, sample containers, tubing, cartridges, pipettes; solid phase extraction cartridges and plates for laboratory use; affinity columns, comprising monoclonal antibodies, for purifying samples for subsequent liquid-chromatography and mass-spectrometry testing for mycotoxin contamination in grain, feed, and food products; computer operating software for analytical apparatus and instruments; computer operating software for analyzing materials by measuring changes in the physical or chemical properties of the materials; computer operating software for bioinformatics, laboratory data analysis, analysis and visualization of data from liquid chromatography and mass spectrometry instruments, discovery, identification, and analysis of chemical compounds; computer operating software for analyzing materials by measuring changes in the physical or chemical properties of the material as the material is subjected to controlled changes in its environment; analytical apparatus and instruments for laboratory use, namely, magnetic suspension balances and parts thereof; analytical apparatus and instruments for laboratory use, namely, flash diffusivity analyzers and parts thereof, mechanical testing instruments, for testing the mechanical or material properties of test samples, rubber testing instruments and parts thereof; mass spectrometer and parts thereof; apparatus and instruments for gravimetric analysis, thermogravimetric analysis or sorption analysis and parts thereof; laboratory apparatus and instruments for gas and vapor dosing and mixing and parts thereof; laboratory apparatus for controlling gas and vapor pressure and parts thereof; analytical apparatus and instruments for analyzing mechanical or material properties of material samples for scientific research purposes, namely, thermal analyzers, rheometers, calorimeters, dilatometers, thermal conductivity meters, flash diffusivity analyzers, and rubber testing instruments; laboratory instruments, namely, specimen testing instruments used to apply cyclic and static loads to a specimen integrated with a controller used for fatigue testing and material testing of the specimen subjected to loads; rheometers for measuring the viscosity and viscoelasticity of fluids, and parts and therefor; calorimeters and parts thereof; dilatometers and parts thereof; laboratory chemical reactors and parts thereof; laboratory instruments, namely, autosamplers; laboratory instruments, namely, pressure cells in the nature of vessels that can withstand high internal pressures; laboratory consumables, namely, vials, containers, trays, plates, pans, tubing, cartridges and pipettes; computer operating software for use with analytical apparatus and instruments; computer operating software for analyzing materials by measuring changes in the physical or chemical properties of the material as the material is subjected to controlled changes in its environment; accessories for use with analytical apparatus and instruments for scientific research purposes, namely, grips and platens, stent and graft testers, cylinders, equipment for cutting specimens, and temperature control units; accessories for analytical apparatus and instruments for scientific research purposes, namely, peltier plate systems in the nature of electrical heating and cooling plates, plate pressure cells in the nature of vessels that can withstand high internal pressures, sensors for sensing the mechanical and material properties of samples, temperature, pressure, motion, distances, force, torque, viscosity, elasticity, material strain, tension, deflection, compression, electrically heated cylinders in the nature of test chambers, relative humidity sensors, optical plates, modular microscope accessory in the nature of microscopes, environmental test chambers, namely, temperature simulation equipment, small angle light scattering diodes, interfacial rheology accessories, namely, accessories for analyzing viscoelasticity, tribo-rheometry accessories, namely, accessories for analyzing friction, magneto-rheology accessories, namely, accessories for analyzing properties of materials subject to magnetic fields, electro-rheology accessories, namely, accessories for analyzing properties of materials subject to electric currents, UV curing accessories, namely, accessories for analyzing properties of materials subject to ultraviolet radiation, dieletric measurement accessories, namely, accessories for analyzing properties of materials subject to an oscillating electrical field, diaelectric thermal analysis accessories, namely, accessories for analyzing properties of materials subject to controlled temperatures and an oscillating electrical field, immobilization cells, namely, test chambers for characterizing the drying, retention, and immobilization kinetics of paints, coatings, and slurries; starch pasting cells, namely, test chambers for analyzing starches, dynamic mechanical analysis accessories, namely, accessories for analyzing material properties of solid materials, refrigerated cooling systems, namely, analytical instrument accessories for controlling sample temperature, laboratory instruments, namely, autosamplers and automated sample processing apparatus and carousels, forced convection oven accessories, namely, analytical instrument accessories for controlling sample temperature, orthogonal superposition accessories, namely, accessories for analyzing nonlinear viscoelasticity, 2-dimensional small amplitude oscillatory shear accessories, namely, accessories for analyzing nonlinear viscoelasticity, extensional viscosity fixture accessories, namely, accessories for analyzing extensional viscosity and stress, cone and partitioned plate accessories, namely, accessories for analyzing elastic materials, interfacial rheology accessories, degassing stations, namely, instruments for removing gasses from samples, clamps for use with analytical instruments, evacuated ampoules made of glass, metal, or plastic for use in testing and analyzing samples for non-medical purposes, sample measuring system accessories, namely, accessories for measuring the mechanical and material properties of samples, temperature, pressure, motion, distances, force, torque, viscosity, elasticity, material strain, tension, deflection, compression
95.
Coaxial introduction of calibrant in a flow path with analyte to an ion source
Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS). The valve may be positioned remotely on a branch that has a junction with the path leading form the source of the mobile phase flow to the ion source. Alternatively, the valve may be positioned in line on the flow path from the source of the mobile phase flow to the ion source of the MS. A novel five port valve design may be employed. With this valve design, a first position of the valve allows a sample loop for the calibrant to be filled. In a second position, the calibrant is added coaxially to the flow from the source of the mobile phase to the MS. In a third position of the valve, diversion of or infusion to a post-source flow is enabled.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
96.
BONDED HYBRID POLYMER NON-POROUS PARTICLES AND THEIR USE FOR BIOSEPARATIONS
The present disclosure pertains to non-porous composite particles that are non-porous, polymer-based particles. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is in contact with the modified surface of the core, and a bonding material is in contact with the non- porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such non-porous composite particles.
The present technology relates to a method of analyzing a sample including an analyte. The method includes injecting the sample including the analyte into a mobile phase. The mobile phase includes a metal chelator additive having a concentration between about 1 ppm to about 10 ppm. The method also includes separating the analyte using liquid chromatography and analyzing the analyte using a mass spectrometer, an ultra-violet detector, or a combination thereof.
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
The present disclosure pertains to composite particles with polymer-based cores, which eliminate the high pH failure mechanism of silica-based core-shell silica particles. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non- porous hybrid organic-inorganic material is in contact with the modified surface of the core, and a porous inorganic material is in contact with the non-porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such composite particles.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The present disclosure pertains to non-porous composite particles that are non-porous, polymer-based, organic-inorganic materials. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is disposed on the modified surface of the core. The present disclosure pertains to chromatographic separation devices that comprise such non-porous composite particles.
The present disclosure pertains to core-shell particles that are superficially porous, polymer- based, and include organic-inorganic materials. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic- inorganic material is in contact with the modified surface of the core, and a porous hybrid organic-inorganic material is in contact with the non-porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such core-shell particles.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
