Disclosed herein are chromatographic materials comprising crosslinked streptavidin molecules. The crosslinked streptavidin chromatographic materials may be used to prepare affinity chromatographic materials using biotinylated affinity agents, such as a biotinylated antibody, biotinylated antigen-binding fragment, or biotinylated oligonucleotide. Due to the crosslinked nature of the streptavidin molecules, the materials provided herein have reduced to no streptavidin leachate, resulting in improved performance.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
C07K 14/36 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from ActinomycesPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Streptomyces (G)
2.
CHROMATOGRAPHIC MATERIALS INCLUDING CROSSLINKED STREPTAVIDIN AND BIOTIN AND METHODS OF USE THEREOF
Disclosed herein are chromatographic materials comprising crosslinked streptavidin particles. The crosslinked streptavidin particles are bound to a biotinylated affinity agent and free biotin. The combined impact of streptavidin crosslinking and binding free biotin to accessible binding sites in streptavidin drastically reduce leaching of streptavidin from the chromatographic materials. The chromatographic materials disclosed herein may be used to prepare affinity chromatographic columns.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
Disclosed herein are chromatographic materials comprising streptavidin molecules, wherein the streptavidin molecules are bound to biotin and one or more biotinylated affinity agents. The biotinylated affinity agent may be a biotinylated antibody, biotinylated antigen-binding fragment, or biotinylated oligonucleotide. The streptavidin chromatographic materials may be used to prepare affinity chromatographic materials. Due to biotin binding to the conjugated streptavidin, the materials provided herein have reduced to no streptavidin leachate, resulting in improved performance.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
A system and method for acquiring and analyzing mechanical test data comprise: receiving, by a mechanical test data management system, a source of data corresponding to a material test from a mechanical test instrument, the source of data having a first file size according to a set of data acquisition parameters generated by the mechanical test data management system, wherein the first file size is a proposed master file size; determining a second file size of the source of data in response to a determination that the proposed master file size is greater than a threshold file size, wherein the second file size is an actual master file size that is acceptable for use by a data analysis tool according to the data acquisition parameters; determining a waveform of the source of data having the second file size; and executing a data analysis tool to search the source of data having the second file size to capture behavior of interest of the material test from at least one segment of the second file size, the at least one segment determined by identifying peak and valley regions of the waveform of the source of data having the second file size.
G06F 3/00 - Input arrangements for transferring data to be processed into a form capable of being handled by the computerOutput arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
5.
ACQUISITION AND MANAGEMENT OF LARGE TEST DATA FILES
A system and method for acquiring and analyzing mechanical test data comprise: receiving, by a mechanical test data management system, a source of data corresponding to a material test from a mechanical test instrument, the source of data having a first file size according to a set of data acquisition parameters generated by the mechanical test data management system, wherein the first file size is a proposed master file size; determining a second file size of the source of data in response to a determination that the proposed master file size is greater than a threshold file size, wherein the second file size is an actual master file size that is acceptable for use by a data analysis tool according to the data acquisition parameters; determining a waveform of the source of data having the second file size; and executing a data analysis tool to search the source of data having the second file size to capture behavior of interest of the material test from at least one segment of the second file size, the at least one segment determined by identifying peak and valley regions of the waveform of the source of data having the second file size.
The present disclosure discusses a method of separating a sample (e.g., pharmaceutical drug, genotoxic impurity, biomarker, and/or biological metabolite) including coating a metallic flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample using mass spectroscopy. In some examples, the coating applied to the surfaces defining the flow path is non-binding with respect to the sample—and the separated sample. Consequently, the sample does not bind to the low-binding surface of the coating of the flow path. The applied coating can increase the chromatographic peak area for the sample of the chromatographic system.
A method for performing liquid chromatography includes receiving, by a receptor of a liquid chromatography sample manager, an original capped vial containing an injectable substance, processing, by an automated system of the liquid chromatography sample manager without human intervention, the injectable substance, and injecting, by the automated system of the liquid chromatography sample manager without human intervention, the injectable substance into a chromatographic flow for analysis. A liquid chromatography sample manager includes an automated system configured to, without human intervention, process the injectable substance; and inject the injectable substance into a chromatographic flow for analysis.
Embodiments described herein relate to improved devices and techniques for improving the calibration of laboratory analytical instruments, especially those whose detector response generally exhibit a non-linear response curve. Some embodiments relate to applying a relatively high voltage at the central pin of a charged aerosol detector's (CAD's) ion trap. By applying a high voltage, relatively more small particles (which generally constitute background reagents) are driven into the ion trap's outer wall, thus improving the CAD's signal-to-noise ratio. Other embodiments, which may be used separately or together with the increased voltage, use calibration standards data and the best-fitting model from a variety of fitting models (which are not limited to a power law function) to transform the raw non-linear data points to linear data points. Consequently, a best linear fit calibration line can be obtained for each individual analyte using the transformation model most appropriate to that analyte.
Embodiments described herein relate to improved nebulizers, and in particular to nebulizers in which the distal end of the inner capillary does not protrude beyond the end of the nebulizer nozzle. The inner capillary is instead recessed within an opening. The opening may be built into the end of a nebulizer that is provided as a single unitary piece, may be built into a nozzle that is a separable part of the nebulizer, or may be built into a shield that is installed on the end of a unitary nebulizer or nebulizer nozzle.
A method for performing liquid chromatography includes receiving, by a receptor of a liquid chromatography sample manager, a sample vial containing a sample; drawing, by an automated needle system of the liquid chromatography sample manager, the sample from the sample container; and diluting, by the automated needle system of the liquid chromatography sample manager, the sample using a dilution system that is self-contained within the sample fluidics of the liquid chromatography sample manager. A liquid chromatography sample manager and/or liquid chromatography system including a sample manager is further provided that is configured to perform the method.
A method for performing liquid chromatography includes receiving, by a receptor of a liquid chromatography sample manager, a sample vial containing a sample; drawing, by an automated needle system of the liquid chromatography sample manager, the sample from the sample container; and diluting, by the automated needle system of the liquid chromatography sample manager, the sample using a dilution system that is self-contained within the sample fluidics of the liquid chromatography sample manager. A liquid chromatography sample manager and/or liquid chromatography system including a sample manager is further provided that is configured to perform the method.
Embodiments described herein relate to improved devices and techniques for improving the calibration of laboratory analytical instruments, especially those whose detector response generally exhibit a non-linear response curve. Some embodiments relate to applying a relatively high voltage at the central pin of a charged aerosol detector's (CAD's) ion trap. By applying a high voltage, relatively more small particles (which generally constitute background reagents) are driven into the ion trap's outer wall, thus improving the CAD's signal-to-noise ratio. Other embodiments, which may be used separately or together with the increased voltage, use calibration standards data and the best-fitting model from a variety of fitting models (which are not limited to a power law function) to transform the raw non-linear data points to linear data points. Consequently, a best linear fit calibration line can be obtained for each individual analyte using the transformation model most appropriate to that analyte.
A method for performing liquid chromatography includes receiving, by a receptor of a liquid chromatography sample manager, an original capped vial containing an injectable substance, processing, by an automated system of the liquid chromatography sample manager without human intervention, the injectable substance, and injecting, by the automated system of the liquid chromatography sample manager without human intervention, the injectable substance into a chromatographic flow for analysis. A liquid chromatography sample manager includes an automated system configured to, without human intervention, process the injectable substance; and inject the injectable substance into a chromatographic flow for analysis.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Kits comprising reagents not for medical use,
chemically-treated test strips and holders for test strips
for the detection of mycotoxins in grain, feed, and food
products; assay kits for detection of chemicals or toxins;
assay kits for testing for mycotoxin contamination in grain,
feed, and food products; assay kits for testing of chemicals
or identifying toxins for laboratory use; chemical test kits
for indicating the presence or absence of toxins for
laboratory or research use; test strips for indicating the
presence or absence of toxins; kits comprising monoclonal
antibodies, buffers and reagents for use in the detection of
chemicals or toxins for non-medical use; chemical reagents;
reagents for detecting chemicals and toxins. Electronic detectors for indicating the presence or absence
of toxins in the fields of agriculture and food processing;
measuring devices, namely, fluorometers; lateral flow
readers; chromatography columns for laboratory use;
chromatography columns for detecting toxins not for medical
use; chromatography columns for preparing samples for
subsequent chromatography and mass-spectrometry testing;
chromatography columns for subsequent chromatography and
mass-spectrometry testing; laboratory apparatus for
detecting toxins and chemicals not for medical use;
electronic detectors for indicating the presence or absence
of toxins in the fields of agriculture, animal feed, grains,
foods and beverage, botanicals, and consumer products;
affinity columns, comprising monoclonal antibodies, for
purifying samples for subsequent liquid-chromatography and
mass-spectrometry testing for mycotoxin contamination in
grain, feed, and food products; prepacked affinity column
for detecting chemicals and toxins. Providing scientific and laboratory information regarding
toxin and chemical testing; providing scientific and
laboratory information regarding compliance with food,
beverage, and agricultural testing regulations; providing
online non-downloadable software for facilitating compliance
with government regulation; providing laboratory testing
information regarding toxin testing regulatory standards via
an online database.
Methods of photodiode array spectrometer calibration include acquiring a first spectrum using a first spectral source of a spectrometer; finding spectral data points at pixel locations from the first spectrum; replacing the first spectral source with a second spectral source in the spectrometer; finding spectral data points at pixel locations using the second spectral source; selecting one or more of the spectral data points; generating a calibration curve by fitting the selected spectral data points to one or more functions of the calibration curve; and using the selected spectral data points and the calibration curve to calibrate the spectrometer.
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
An automated sample processing system for preparing a sample comprising polypeptides for analysis, comprising: a first valve (e.g. Valve 5); a second valve (e.g. Valve 3); a third valve (e.g. Valve 1), where a port of the third valve is in fluid communication with a port of the first valve or a port of the second valve; a first fluid holding coil (e.g. holding coil 32) connected to a port of the second valve; a second fluid holding coil (e.g. holding coil 5) connected to a port of the third valve; and at least one pump for pumping fluid through the system.
Methods of photodiode array spectrometer calibration include acquiring a first spectrum using a first spectral source of a spectrometer; finding spectral data points at pixel locations from the first spectrum; replacing the first spectral source with a second spectral source in the spectrometer; finding spectral data points at pixel locations using the second spectral source; selecting one or more of the spectral data points; generating a calibration curve by fitting the selected spectral data points to one or more functions of the calibration curve; and using the selected spectral data points and the calibration curve to calibrate the spectrometer.
A method of aspirating a sample includes moving a sample needle downward to a first position so a tip of the sample needle touches a bottom of the sample container, determining that the tip of the sample needle is in the first position where the sample needle is in contact with the bottom of the sample container, after the determining that the tip of the sample needle is in contact with the bottom of the sample container, incrementally moving the sample needle upward from the first position, determining the sample needle has moved a predetermined distance upward from the first position and then aspirating a sample in the sample container.
Disclosed herein are antigen chromatography columns. Said antigen chromatography columns utilize streptavidin-functionalized particles, wherein the streptavidin binding sites are occupied with one or more biotinylated antigens. In this way, said antigen chromatography columns may be used to isolate, purify, and characterize antibodies (or other proteins) that specifically bind to said antigens.
B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
21.
ANTIGEN CHROMATOGRAPHY COLUMNS AND METHODS OF USE THEREOF
Disclosed herein are antigen chromatography columns. Said antigen chromatography columns utilize streptavidin-functionalized particles, wherein the streptavidin binding sites are occupied with one or more biotinylated antigens. In this way, said antigen chromatography columns may be used to isolate, purify, and characterize antibodies (or other proteins) that specifically bind to said antigens.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
B01J 20/30 - Processes for preparing, regenerating or reactivating
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
Chemical products for use in chromatography, namely chemical reagents, packing material for columns, packed columns; chemical reagents, other than for medical purposes, and other chemical preparations and substances for use as column packing material; chemical reagents and other chemical preparations and substances for column packing, including for use in chromatography; chemicals including chromatography chemicals, chemical reagents, column packing and packed column. Chromatography columns; chromatography columns for use in connection with liquid chromatography instruments; chromatography columns for preparing and analyzing laboratory samples.
09 - Scientific and electric apparatus and instruments
Goods & Services
Devices for carrying out chemical reactions and for separating reaction products in the analysis of amino acids, for use in laboratory settings as well as for industrial purposes and accessories therefor, namely chromatographic columns, solvents, eluents, reagents, and vacuum or sub-pressure devices suitable for use therewith; instruments for the derivatization, separation and analysis of amino acids, and accessories, such as chromatographic columns, solvents, eluents, reagents, and vacuum equipment used with them; chromatography columns; chromatography columns for use in connection with liquid chromatography instruments; chromatography columns for preparing and analyzing laboratory samples.
A rheometer shaft system includes an output shaft including an axial thrust disk, an upper air bearing surrounding the output shaft located above the axial thrust disk, and a lower air bearing surrounding the output shaft located below the axial thrust disk. An upper gap separates the axial thrust disk of the output shaft and the upper air bearing. A lower gap separates the axial thrust disk of the output shaft and the lower air bearing. An airflow detection system is configured to detect a change in airflow to the upper air bearing and the lower air bearing based on the movement in the axial direction of the output shaft. This change in airflow can be used to monitor normal force applied to the rheometer shaft.
G01N 11/14 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane
A rheometer shaft system includes an output shaft including an axial thrust disk, an upper air bearing surrounding the output shaft located above the axial thrust disk, and a lower air bearing surrounding the output shaft located below the axial thrust disk. An upper gap separates the axial thrust disk of the output shaft and the upper air bearing. A lower gap separates the axial thrust disk of the output shaft and the lower air bearing. An airflow detection system is configured to detect a change in airflow to the upper air bearing and the lower air bearing based on the movement in the axial direction of the output shaft. This change in airflow can be used to monitor normal force applied to the rheometer shaft.
G01L 5/12 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for measuring axial thrust in a rotary shaft, e.g. of propulsion plants
G01L 5/00 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes
G01N 3/06 - Special adaptations of indicating or recording means
G01N 3/307 - Investigating strength properties of solid materials by application of mechanical stress by applying a single impulsive force generated by a compressed or tensile-stressed springInvestigating strength properties of solid materials by application of mechanical stress by applying a single impulsive force generated by pneumatic or hydraulic means
27.
SAMPLE TRAY FOR AUTOMATED OR SEMI-AUTOMATED SAMPLE PREPARATION AND TESTING
A sample tray for thermal analysis includes a tray body including a plurality of wells, wherein each well is configured to receive a sample pan and a sample lid. The sample pan is configured to receive a sample for thermal analysis, wherein the sample lid is configured to be crimped to the sample pan to create a seal between the sample lid and the sample pan, and the tray body is configured to be received into an automated sample preparation system to prepare samples for thermal analysis. A method of manufacturing a sample tray is also disclosed.
Provided herein are methods for extracting nucleic acids from tissue samples. The methods can be used for the isolation of exogenous nucleic acids, including saccharide-conjugated nucleic acids, from a tissue sample. The methods allow for efficient extraction of the nucleic acids with compatibility for downstream analysis.
Provided herein are methods for extracting nucleic acids from tissue samples. The methods can be used for the isolation of exogenous nucleic acids, including saccharide-conjugated nucleic acids, from a tissue sample. The methods allow for efficient extraction of the nucleic acids with compatibility for downstream analysis.
A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I:
A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I:
A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I:
R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20-, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.
A calorimeter lifting tool for holding a pouch cell battery within a calorimeter includes a base including a first pressure surface, a pressure plate including a second pressure surface, the pressure plate attachable to the base such that the first pressure surface of the base and the second pressure surface of the pressure plate define a space between which a pouch cell battery having a first cell surface and an opposing second cell surface is configured be held such that a first pressure surface of the base applies pressure to the first cell surface of the pouch cell battery and the second pressure surface of the pressure plate applies pressure to the second cell surface of the pouch cell battery, and a terminal connector system configured to connect to terminals of the held pouch cell battery, the terminal connector system configured to connect with a battery cycler system.
Disclosed are methods of controlling a rheometer. Methods include receiving, by a control device, an operating procedure for a test, the operating procedure including a plurality of sequential steps for performing the test and controlling the rheometer according to the operating procedure to perform the test. Controlling includes sequentially presenting, to a user of the rheometer, the plurality of sequential steps, determining whether the operating procedure has been met for a respective sequential step of the plurality of sequential steps for performing the test, and proceeding to a subsequent step of the plurality of sequential steps for performing the test only when the operating procedure has been met for the respective sequential step.
Disclosed are methods of controlling a rheometer. Methods include receiving, by a control device, an operating procedure for a test, the operating procedure including a plurality of sequential steps for performing the test and controlling the rheometer according to the operating procedure to perform the test. Controlling includes sequentially presenting, to a user of the rheometer, the plurality of sequential steps, determining whether the operating procedure has been met for a respective sequential step of the plurality of sequential steps for performing the test, and proceeding to a subsequent step of the plurality of sequential steps for performing the test only when the operating procedure has been met for the respective sequential step.
Rheological systems, control devices for a rheometer, and computer program products that implement methods of controlling a rheometer are also disclosed.
G01N 11/14 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane
G01N 11/00 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties
34.
POUCH CELL BATTERY COMPRESSION AMPOULE FOR A CALORIMETER
A calorimeter lifting tool for holding a pouch cell battery within a calorimeter includes a base including a first pressure surface, a pressure plate including a second pressure surface, the pressure plate attachable to the base such that the first pressure surface of the base and the second pressure surface of the pressure plate define a space between which a pouch cell battery having a first cell surface and an opposing second cell surface is configured be held such that a first pressure surface of the base applies pressure to the first cell surface of the pouch cell battery and the second pressure surface of the pressure plate applies pressure to the second cell surface of the pouch cell battery, and a terminal connector system configured to connect to terminals of the held pouch cell battery, the terminal connector system configured to connect with a battery cycler system.
G01L 5/04 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for measuring tension in flexible members, e.g. ropes, cables, wires, threads, belts or bands
G01L 5/22 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes for measuring the force applied to control members, e.g. control members of vehicles, triggers
Disclosed are methods of controlling a rheometer. Methods include receiving, by a control device, an operating procedure for a test, the operating procedure including a plurality of sequential steps for performing the test and controlling the rheometer according to the operating procedure to perform the test. Controlling includes sequentially presenting, to a user of the rheometer, the plurality of sequential steps, determining whether the operating procedure has been met for a respective sequential step of the plurality of sequential steps for performing the test, and proceeding to a subsequent step of the plurality of sequential steps for performing the test only when the operating procedure has been met for the respective sequential step. Rheological systems, control devices for a rheometer, and computer program products that implement methods of controlling a rheometer are also disclosed.
G01N 11/00 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties
G01N 11/14 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane
G01N 11/16 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by moving a body within the material by measuring damping effect upon oscillatory body
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
36.
USE OF VAPOR DEPOSITION COATED FLOW PATHS FOR IMPROVED ANALYTICAL ANALYSIS
A device for processing samples is disclosed. Interior surfaces of the device, which come in contact with fluids, define wetted surfaces. A portion of the wetted surfaces are coated with an alkylsilyl coating having the Formula I.
A device for processing samples is disclosed. Interior surfaces of the device, which come in contact with fluids, define wetted surfaces. A portion of the wetted surfaces are coated with an alkylsilyl coating having the Formula I.
A device for processing samples is disclosed. Interior surfaces of the device, which come in contact with fluids, define wetted surfaces. A portion of the wetted surfaces are coated with an alkylsilyl coating having the Formula I.
R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.
Disclosed herein are methods that provide optimal conditions for site-specific digestion and mapping of the sequence of RNA polynucleotides using T2 family endoribonucleases, such as RNase MC1 and Cusativin.
Described is a device for removal of excess material from a test sample. The test sample may be used in an instrument for measurement of rheological and mechanical properties sample properties. The device includes a test geometry and a trimming ring. The test geometry includes a lower geometry and upper geometry each having a circular outer edge and being centered on an axis of rotation. The trimming ring has a sidewall, a ring axis coincident with the axis of rotation and at least one cutting edge disposed along at least a portion of a circumference of the trimming ring at a diameter that is at least as great as a diameter of one or both the lower geometry and the upper geometry. The device further includes an actuator coupled to the trimming ring and configured to translate the trimming ring in a direction parallel to the axis of rotation.
B26D 1/15 - Cutting through work characterised by the nature or movement of the cutting memberApparatus or machines thereforCutting members therefor involving a cutting member which does not travel with the work having a cutting member moving about an axis with a circular cutting member, e.g. disc cutter rotating about a stationary axis with vertical cutting member
39.
METHODS OF INDUCING SITE-SPECIFIC CLEAVAGE OF RNA POLYNUCLEOTIDES WITH T2 FAMILY RIBONUCLEASES
Disclosed herein are methods that provide optimal conditions for site-specific digestion and mapping of the sequence of RNA polynucleotides using T2 family endoribonucleases, such as RNase MCI and Cusativin.
The present disclosure pertains to composite particles with polymer-based cores, which eliminate the high pH failure mechanism of silica-based core-shell silica particles. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is in contact with the modified surface of the core, and a porous inorganic material is in contact with the non-porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such composite particles.
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The present disclosure relates to a system for a composition for protein denaturation. The composition includes a non-nucleophilic denaturant comprising a substituted guanidine, wherein the denaturant has a pKa value greater than about 10, and wherein the concentration of the substituted guanidine is less than 250 mM.
C07K 1/113 - General processes for the preparation of peptides by chemical modification of precursor peptides without change of the primary structure
C07C 257/14 - Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
C07C 279/04 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
A method of mass spectrometry comprising: supplying a sample to be mass analysed to a liquid chromatography separator, whilst varying a liquid flow rate through the separator such that liquid elutes from the separator at a first rate during a first period and a second, lower rate during a second period; ionising eluant from the separator during at least the second period; and mass analysing the resulting ions, or ions derived therefrom, by charge detection mass spectrometry.
A method of mass spectrometry comprising: supplying a sample to be mass analysed to a liquid chromatography separator, whilst varying a liquid flow rate through the separator such that liquid elutes from the separator at a first rate during a first period and a second, lower rate during a second period; ionising eluant from the separator during at least the second period; and mass analysing the resulting ions, or ions derived therefrom, by charge detection mass spectrometry.
Described is a method of controlling a material testing system that includes controlling an actuator to transfer a first force acting in a first direction to a test material. The method further includes receiving, via one or more sensors, continuous data indicating one or more physical quantities associated with the test material. Based upon the continuous data, it may be determined that a change in one or more physical quantities has occurred. Based upon a change in one or more physical quantities it may be determined that an end point of a material test has been reached. The method further includes controlling an actuator to stop transfer of the first force and further to controlling the actuate to transfer a second force which acts to counteract the effects of the first force and prevent unwanted motion of one or more portions of the material testing system.
Described is a method of controlling a material testing system that includes controlling an actuator to transfer a first force acting in a first direction to a test material. The method further includes receiving, via one or more sensors, continuous data indicating one or more physical quantities associated with the test material. Based upon the continuous data, it may be determined that a change in one or more physical quantities has occurred. Based upon a change in one or more physical quantities it may be determined that an end point of a material test has been reached. The method further includes controlling an actuator to stop transfer of the first force and further to controlling the actuate to transfer a second force which acts to counteract the effects of the first force and prevent unwanted motion of one or more portions of the material testing system.
G01N 3/10 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces generated by pneumatic or hydraulic pressure
09 - Scientific and electric apparatus and instruments
Goods & Services
Calorimeters; Isothermal calorimeter; Rheometers; Viscometers; Dilatometers; thermomechanical analyzers; laboratory apparatus and instruments for isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), thermomechanical analysis (TMA), dynamic mechanical analysis (DMA), gravimetric analysis (GA), thermogravimetric analysis (TGA), sorption analysis (SA), laser flash analysis (LFA); laboratory apparatus and instruments for measuring viscosity, viscoelasticity, material stress; laboratory sample pans, pan covers, and crimper presses for thermal analysis instruments; replacement parts and fittings for laboratory apparatus and instruments, namely, for calorimeters, Isothermal calorimeter, Rheometers, Viscometers, Dilatometers, thermomechanical analyzers; replacement parts and fittings for laboratory apparatus and instruments for isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), thermomechanical analysis (TMA), dynamic mechanical analysis (DMA), gravimetric analysis (GA), thermogravimetric analysis (TGA), sorption analysis (SA), and laser flash analysis (LFA); replacement parts and fittings for laboratory apparatus and instruments for measuring viscosity, viscoelasticity, material stress; accessories for analytical apparatus and instruments, namely, autosamplers and automated sample processing apparatus and carousels therefor; accessories for temperature and environmental control, namely, peltier plate systems in the nature of electrical heating and cooling plates; accessories for analytical apparatus and instruments for laboratory use for temperature and environmental control, namely, plate pressure cells in the nature of vessels that can withstand high internal pressures; accessories for analytical apparatus and instruments for laboratory use for temperature and environmental control, namely, environmental test chambers, namely, temperature simulation equipment, refrigerated cooling systems in the nature of analytical instrument accessories for controlling sample temperature; accessories for analytical apparatus and instruments for laboratory use for temperature and environmental control, namely, electrically heated cylinders in the nature of environmental test chambers; accessories for analytical apparatus and instruments for laboratory use for temperature and environmental control, namely, forced convection oven for controlling sample temperature; accessories for analytical apparatus and instruments for laboratory use, namely, sensors for sensing the mechanical and material properties of samples, temperature, pressure, relative humidity, motion, distances, force, torque, viscosity, elasticity, material strain, tension, deflection, and compression; accessories for analytical apparatus and instruments for laboratory use, namely, optical plates; accessories for analytical apparatus and instruments for laboratory use, namely, small angle light scattering diodes; accessories for analytical apparatus and instruments for laboratory use, namely, interfacial rheology instrument for analyzing viscoelasticity; accessories for analytical apparatus and instruments for laboratory use, namely, tribo-rheometry instrument for analyzing friction; accessories for analytical apparatus and instruments for laboratory use, namely, magneto-rheology instrument for analyzing properties of materials subject to magnetic fields; accessories for analytical apparatus and instruments for laboratory use, namely, electro-rheology instrument for analyzing properties of materials subject to electric currents; accessories for analytical apparatus and instruments for laboratory use, namely, UV curing instrument for analyzing properties of materials subject to ultraviolet radiation; accessories for analytical apparatus and instruments for laboratory use, namely, dieletric measurement instrument for analyzing properties of materials subject to an oscillating electrical field; accessories for analytical apparatus and instruments for laboratory use, namely, diaelectric thermal analysis instrument for analyzing properties of materials subject to controlled temperatures and an oscillating electrical field; accessories for analytical apparatus and instruments for laboratory use, namely, immobilization cells in the nature of environmental test chambers for characterizing the drying, retention, and immobilization kinetics of paints, coatings, and slurries; laboratory apparatus and instruments in the nature of starch pasting cells, namely, environmental test chambers for analyzing starches; dynamic mechanical analysis accessories, namely, dynamic mechanical analysis instrument for analyzing material properties of solid materials; orthogonal superposition accessories, namely, instruments for analyzing nonlinear viscoelasticity; 2-dimensional small amplitude oscillatory shear accessories, namely, instruments for analyzing nonlinear viscoelasticity; extensional viscosity fixture accessories, namely, instruments for analyzing extensional viscosity and stress; laboratory apparatus and instruments in the nature of cone and partitioned plate accessories, namely, instruments used for analyzing elastic materials; degassing stations, namely, laboratory apparatus and instruments for removing gasses from samples; accessories for interfacial rheometers for measuring the viscosity and viscoelasticity of fluids, namely, sample cups and bobs; accessories for rheometers for measuring the viscosity and viscoelasticity of fluids, namely, helical bobs and vane bobs; calorimeter incorporating air-based temperature control; recorded or downloadable software for calorimeters, rheometers, thermomechanical analyzers, viscometers, dilatometers, and instruments for gravimetric analysis, theromogravametric analysis, sorption analysis, thermal analysis, thermal conductivity, dynamic mechanical analysis, and laser flash analysis; recorded or downloadable software for collecting, analyzing, storing, and reporting data from laboratory instruments; recorded or downloadable software for laboratory informatics, instrument control, sample management, managing laboratory workflow, validating laboratory processes, developing and testing analytical methods, facilitating regulatory compliance; recorded or downloadable computer software for collecting, organizing, analyzing, and managing data from analytical equipment in the fields of material testing, chemicals, pharmaceuticals, life sciences, medical devices, electronics, batteries, rubber, aerospace, military, defense, composites, and polymers; recorded or downloadable software for polymer characterization workflows and data analysis in connection with thermal analysis instruments; recorded or downloadable operating software for rubber testing and battery testing instruments; recorded or downloadable software for controlling rubber-testing instruments, generating test results, and managing data from instruments used in rubber testing, namely, RPA analyzers, Mooney viscometers, MDR systems, hardness testers and density testers
09 - Scientific and electric apparatus and instruments
Goods & Services
Calorimeters; Isothermal calorimeter; Rheometers; Viscometers; Dilatometers; thermomechanical analyzers; laboratory apparatus and instruments for isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), thermomechanical analysis (TMA), dynamic mechanical analysis (DMA), gravimetric analysis (GA), thermogravimetric analysis (TGA), sorption analysis (SA), laser flash analysis (LFA); laboratory apparatus and instruments for measuring viscosity, viscoelasticity, material stress; laboratory sample pans, pan covers, and crimper presses for thermal analysis instruments; replacement parts and fittings for laboratory apparatus and instruments; accessories for analytical apparatus and instruments; calorimeter incorporating air-based temperature control; recorded or downloadable software for calorimeters, rheometers, thermomechanical analyzers, viscometers, dilatometers, and instruments for gravimetric analysis, theromogravametric analysis, sorption analysis, thermal analysis, thermal conductivity, dynamic mechanical analysis, and laser flash analysis; recorded or downloadable software for collecting, analyzing, storing, and reporting data from laboratory instruments; recorded or downloadable software for laboratory informatics, instrument control, sample management, managing laboratory workflow, validating laboratory processes, developing and testing analytical methods, facilitating regulatory compliance; recorded or downloadable computer software for analytical equipment in the fields of material testing, chemicals, pharmaceuticals, life sciences, medical devices, electronics, batteries, rubber, aerospace, military, defense, composites, and polymers; recorded or downloadable software for rubber-testing and battery testing instruments
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable software for data analysis for laboratory instruments; Downloadable software for collecting, analyzing, storing, and reporting data in chromatography and mass spectrometry applications; Downloadable software for collecting, analyzing, storing, and reporting data for use in scientific analysis; Downloadable software for laboratory informatics; Downloadable software for managing laboratory workflow, namely, software for controlling, organizing, and tracking laboratory testing projects, laboratory test results, laboratory staff utilization, and reagent and sample inventories; Downloadable software for validating processes in chromatography and mass spectrometry laboratories; Downloadable software for facilitating laboratory compliance with government regulation; Downloadable software for laboratory analytical method development, testing, and validation management, namely, for creating, testing, and validating methods for using analytical instruments for laboratory use; Downloadable software for collecting, organizing, analyzing, and managing data from analytical equipment in the chemical, pharmaceutical, life sciences, environmental, clinical diagnostic, food science and safety, and forensic toxicology fields; Downloadable software for purification of samples in chromatography and spectrometry applications; Downloadable software for automating chromatography and mass spectrometry operations for chromatography and mass spectrometry apparatus; Downloadable software for laboratory and sample management; Downloadable software for controlling and operating chromatography and spectrometry instruments; Downloadable software for clinical diagnostic testing for use with chromatography and spectrometry instruments; Recorded software for data analysis for laboratory instruments; Recorded software for collecting, analyzing, storing, and reporting data in chromatography and mass spectrometry applications; Recorded software for collecting, analyzing, storing, and reporting data for use in scientific analysis; Recorded software for laboratory informatics; Recorded software for managing laboratory workflow, namely, software for controlling, organizing, and tracking laboratory testing projects, laboratory test results, laboratory staff utilization, and reagent and sample inventories; Recorded software for validating processes in chromatography and mass spectrometry laboratories; Recorded software for facilitating laboratory compliance with government regulation; Recorded software for laboratory analytical method development, testing, and validation management, namely, for creating, testing, and validating methods for using analytical instruments for laboratory use; Recorded software for collecting, organizing, analyzing, and managing data from analytical equipment in the chemical, pharmaceutical, life sciences, environmental, clinical diagnostic, food science and safety, and forensic toxicology fields; Recorded software for purification of samples in chromatography and spectrometry applications; Recorded software for automating chromatography and mass spectrometry operations for chromatography and mass spectrometry apparatus; Recorded software for laboratory and sample management; Recorded software for controlling and operating chromatography and spectrometry instruments; Recorded software for clinical diagnostic testing for use with chromatography and spectrometry instruments; Downloadable reports featuring data analysis results for laboratory instruments; Downloadable reports featuring information about collecting, analyzing, storing, and reporting data in chromatography and mass spectrometry applications; Downloadable reports featuring data from collecting, analyzing, storing, and reporting data for use in scientific analysis; Downloadable reports featuring laboratory informatics; Downloadable reports featuring information about managing laboratory workflow; Downloadable reports featuring information on validating processes in chromatography and mass spectrometry laboratories; Downloadable reports featuring information about facilitating laboratory compliance with government regulation; Downloadable reports featuring information on laboratory analytical method development, testing, and validation management, namely, on creating, testing, and validating methods for using analytical instruments for laboratory use; Downloadable reports featuring information about collecting, organizing, analyzing, and managing data from analytical equipment in the chemical, pharmaceutical, life sciences, environmental, clinical diagnostic, food science and safety, and forensic toxicology fields; Downloadable reports featuring information on purification of samples in chromatography and spectrometry applications; Downloadable reports featuring information on automating chromatography and mass spectrometry operations for chromatography and mass spectrometry apparatus; Downloadable reports featuring information about laboratory and sample management; Downloadable reports featuring information about chromatography and spectrometry instruments; Liquid chromatography apparatus for laboratory use; Gas chromatography apparatus for laboratory use; Automatic chromatography apparatus for laboratory use; Automatic ion-exchange chromatography apparatus for laboratory use; Apparatus for automatic chromatography for laboratory use; Automatic ion exchange chromatography apparatus for laboratory use; Laboratory apparatus and chromatography systems for use in protein purification; Scientific apparatus and instruments, namely, chromatography columns for use in purification in the laboratory and parts and fittings therefor Software as a service (SAAS) services featuring software for computer operating and data analysis software for chromatography and spectrometry instruments; Software as a service (SAAS) services featuring software for collecting, analyzing, storing, and reporting data in chromatography and mass spectrometry applications; Software as a service (SAAS) services featuring software for collecting, analyzing, storing, and reporting data for scientific analysis; Software as a service (SAAS) services featuring software for laboratory informatics; Software as a service (SAAS) services featuring software for managing laboratory workflow, namely, software for controlling and organizing laboratory testing, laboratory test results, laboratory staff utilization, and reagent and sample inventories; Software as a service (SAAS) services featuring software for validating processes in chromatography and mass spectrometry laboratories; Software as a service (SAAS) services featuring software for facilitating laboratory compliance with government regulation; Software as a service (SAAS) services featuring software for laboratory analytical method development, testing, and validation management, namely, for creating, testing, and validating methods for using analytical instruments for laboratory use; Software as a service (SAAS) services featuring software for collecting, organizing, analyzing, and managing data from analytical equipment in the chemical, pharmaceutical, life sciences, environmental, clinical diagnostic, food science and safety, and forensic toxicology fields; Software as a service (SAAS) services featuring software for validating processes in a chromatography and mass spectrometry laboratories; software as a service (SAAS) services featuring software for purification of samples in chromatography and spectrometry applications; Software as a service (SAAS) services featuring software for automating chromatography and mass spectrometry operations; Software as a service (SAAS) services featuring software for laboratory and sample management; Software as a service (SAAS) services featuring software for updating and maintenance of laboratory instrument and laboratory management computer software; Providing temporary use of online non-downloadable computer software for computer operating and data analysis software for chromatography and spectrometry instruments; Providing temporary use of online non-downloadable computer software for collecting, analyzing, storing, and reporting data in chromatography and mass spectrometry applications; Providing temporary use of online non-downloadable computer software for collecting, analyzing, storing, and reporting data for scientific analysis; Providing temporary use of online non-downloadable computer software for laboratory informatics; Providing temporary use of online non-downloadable computer software for managing laboratory workflow, namely, software for controlling and organizing laboratory testing, laboratory test results, laboratory staff utilization, and reagent and sample inventories; Providing temporary use of online non-downloadable computer software for validating processes in chromatography and mass spectrometry laboratories; Providing temporary use of online non-downloadable computer software for facilitating laboratory compliance with government regulation; Providing temporary use of online non-downloadable computer software for laboratory analytical method development, testing, and validation management, namely, for creating, testing, and validating methods for using analytical instruments for laboratory use; Providing temporary use of online non-downloadable computer software for collecting, organizing, analyzing, and managing data from analytical equipment in the chemical, pharmaceutical, life sciences, environmental, clinical diagnostic, food science and safety, and forensic toxicology fields; Providing temporary use of online non-downloadable computer software for validating processes in a chromatography and mass spectrometry laboratories; Providing temporary use of online non-downloadable computer software for automating chromatography and mass spectrometry operations; Providing temporary use of online non-downloadable computer software for laboratory and sample management; Updating of computer software; Maintenance of computer software; Technical support services, namely, troubleshooting of computer software problems; Technical advice relating to operation of computers; Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of scientific analytical apparatus and instruments, specifically, technical verification and validation of laboratory instruments in the chemical, pharmaceutical, life sciences, environmental, clinical diagnostic, food science and safety, and forensic toxicology fields
51.
SOLVENT DELIVERY WITH A REDUCED VOLUME SINGLE STROKE PUMPING ARRANGEMENT PROVIDING CONTINUOUS SOLVENT FLOW
The exemplary embodiments control solvent pumps so that system flow is constant. One or more controllers may control the flow rate produced by the pumps over time. The one or more controllers control a first pump so that, as the first pump is refilling, a second pump maintains a sufficient flow rate to compensate for the lost flow due to the refilling event. In some exemplary embodiments, the one or more controllers control the timing of the refilling event for the first event such that the refilling event overlaps with the equilibrating of the chromatography column with solvent(s) from the second pump. Similarly, the one or more controllers control the timing of the refilling event for the second pump such that the refilling event overlaps with the equilibrating of the chromatography column.
The present disclosure is directed to a kit for evaluating system inertness. The kit includes a positive control comprising a metal interacting moiety, and a negative control that does not contain a metal interacting moiety. In some embodiments the kit also includes a container to hold a system suitability solution (e.g., an equimolar mixture of the positive control and the negative control).
The present disclosure is directed to methods of performing size-exclusion chromatography for the separation and characterization of lipid nanoparticles and compositions or samples comprising the same. The methods provided herein afford improved separation and characterization of lipid nanoparticles, including aggregate formation.
G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
54.
METHODS FOR ANALYZING LIPID NANOPARTICLES AND USES THEREOF
The present disclosure is directed to methods of performing size-exclusion chromatography for the separation and characterization of lipid nanoparticles and compositions or samples comprising the same. The methods provided herein afford improved separation and characterization of lipid nanoparticles, including aggregate formation.
Described is an absorbance detector that can be used, for example, to detect analytes in a chromatography system flow. The absorbance detector includes separate temperature controlled zones that can be operated at different temperatures. A first temperature controlled zone includes a light source to provide light to probe a flow cell. A second temperature controlled zone includes the flow cell, a photodiode array and an optical system that is configured to direct light from the light source through the flow cell and to spectrally disperse the light across the photodiode array. The first and second temperature controlled zones may include a first housing and a second housing, respectively, to substantially enclose the components of their respective zones and to thermally isolate the zones from each other. A thermal isolator may be disposed between the temperature controlled zones to reduce heat transfer.
A nebulizer spray chamber assembly lacks a horizontally extending rib or partition. The lack of the horizontally extending rib or partition prevents droplets in a spray chamber from falling into a plume. The nebulizer spray chamber assembly has an exit oriented in a direction that an aerosol plume is introduced into the spray chamber (i.e., a primary horizontal direction). Since there is no change in direction of gas flow toward the nebulizer nozzle, more droplets may be detected by a detector, such as a charged aerosol detector.
A nebulizer spray chamber assembly lacks a horizontally extending rib or partition. The lack of the horizontally extending rib or partition prevents droplets in a spray chamber from falling into a plume. The nebulizer spray chamber assembly has an exit oriented in a direction that an aerosol plume is introduced into the spray chamber (i.e., a primary horizontal direction). Since there is no change in direction of gas flow toward the nebulizer nozzle, more droplets may be detected by a detector, such as a charged aerosol detector.
B05B 1/26 - Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectorsBreaking-up the discharged liquid or other fluent material by impinging jets
Described is an absorbance detector (10) that can be used, for example, to detect analytes in a chromatography system flow. The absorbance detector (10) includes separate temperature controlled zones (ZONE1, ZONE2) that can be operated at different temperatures. A first temperature controlled zone (ZONE1) includes a light source (20) to provide light to probe a flow cell (30). A second temperature controlled zone (ZONE2) includes the flow cell (30), a photodiode array (40) and an optical system that is configured to direct light (22) from the light source (20) through the flow cell (30) and to spectrally disperse the light across the photodiode array (40). The first and second temperature controlled zones (ZONE1, ZONE2) include a first housing (52) and a second housing (54), respectively, to substantially enclose the components of their respective zones (ZONE1, ZONE2) and to thermally isolate the zones (ZONE1, ZONE2) from each other. A thermal isolator (56) may be disposed between the temperature controlled zones (ZONE1, ZONE2) to reduce heat transfer.
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
The present disclosure is directed to nonporous polymer particles having an average particle size of 1 to 10 microns and being functionalized with an enzyme, such as trypsin. The enzyme-immobilized particles, and immobilized enzyme reactors thereof, can be used in methods for on-line protein digestion.
C12N 11/082 - Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
C12N 11/06 - Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
C12M 1/40 - Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
C12P 21/06 - Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS
Novel chromatographic materials for chromatographic separations, columns, kits, and methods for preparation and separations with a superficially porous material comprising a substantially nonporous core and one or more layers of a porous shell material surrounding the core. The material of the invention is comprised of superficially porous particles and a narrow particle size distribution. The material of the invention is comprised of a superficially porous monolith, the substantially nonporous core material is silica and the porous shell material is an inorganic/organic hybrid material.
Disclosed herein are methods of mapping a sequence of an RNA molecule comprising the steps of hybridizing a protecting primer with a portion the RNA molecule to form RNA/primer hybrid, combining the RNA molecule, the primer, and a digestion assay, digesting the RNA molecule hybridized with the primer in the digestion assay, and analyzing the two or more RNA fragments using liquid chromatography-mass spectrometry to determine the sequence of nucleotides in the RNA molecule. Also disclosed herein are digestion assays for selectively cleaving an RNA molecule into two or more RNA fragments.
C12Q 1/6872 - Methods for sequencing involving mass spectrometry
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
C12Q 1/6816 - Hybridisation assays characterised by the detection means
62.
PAN STATUS INDICATOR LIGHT FOR ANALYTICAL INSTRUMENT SAMPLE TRAY
A tray status indicator system comprises a tray comprising a plurality of wells. Each well in the plurality of wells is configured to receive a sample or reference material. A light emitting diode (LED) arrangement is below the plurality of wells. Each LED in the LED arrangement is below a well of the plurality of wells. The system also comprises an instrument control system that generates and outputs control signals to the LED arrangement to illuminate the each LED in the LED arrangement at a predetermined color of a plurality of different colors that indicate a state of a sample or reference in the well.
G01N 1/36 - Embedding or analogous mounting of samples
F21V 9/40 - Elements for modifying spectral properties, polarisation or intensity of the light emitted, e.g. filters with provision for controlling spectral properties, e.g. colour, or intensity
A tray status indicator system comprises a tray comprising a plurality of wells. Each well in the plurality of wells is configured to receive a sample or reference material. A light emitting diode (LED) arrangement is below the plurality of wells. Each LED in the LED arrangement is below a well of the plurality of wells. The system also comprises an instrument control system that generates and outputs control signals to the LED arrangement to illuminate the each LED in the LED arrangement at a predetermined color of a plurality of different colors that indicate a state of a sample or reference in the well.
The present disclosure is directed to nonporous polymer particles having an average particle size of 1 to 10 microns and being functionalized with an enzyme, such as trypsin. The enzyme-immobilized particles, and immobilized enzyme reactors thereof, can be used in methods for on-line protein digestion.
The present disclosure relates to chemically modified protease enzymes, Lys-C and Lys-N, that have enhanced autolysis resistance. Also disclosed herein are methods of using such protease enzymes for improving detection of target analyte proteins in an analytical assay.
C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase
66.
CHEMICALLY MODIFIED PROTEASE ENZYMES WITH ENHANCED AUTOLYSIS RESISTANCE
The present disclosure relates to chemically modified protease enzymes, Lys-C and Lys- N, that have enhanced autolysis resistance. Also disclosed herein are methods of using such protease enzymes for improving detection of target analyte proteins in an analytical assay.
An apparatus for performing electrical and rheological measurements of a powder sample includes an upper geometry including a first electrode, a lower geometry including a bottom surface and a second electrode, a sidewall forming a perimeter located between the upper geometry and the bottom surface of the lower geometry, a sample gap located between the upper geometry and the lower geometry and within the perimeter of the sidewall, the powder sample locatable in the sample gap such that the first electrode and the second electrode are in contact with the powder sample, an electrical measurement system operably connected to each of the first electrode and the second electrode configured to measure electrical properties of the powder sample during a rheological test, and a mechanical measurement system configured to measure mechanical properties of the powder sample located in the sample gap during the rheological test.
G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
G01N 11/14 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane
G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
68.
INTEGRATED AUTOMATED SAMPLE PREPARATION FOR THERMAL ANALYTICAL INSTRUMENTS
A method of automated sample preparation for thermal analysis includes picking up, with an automated gripping system of an autosampler, a pan located in a pan well of a sample tray; and performing an automated sample preparation procedure including at least one of: providing the pan to a balance module by the automated gripping system, wherein the balance module is configured to perform weight measurement on the pan; and providing the pan to a crimping module by the automated gripping system after a sample is loaded into the pan, wherein the crimping module is configured to seal the pan with an automated crimping process.
G01N 25/48 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
69.
MEASUREMENT OF ELECTRICAL PROPERTIES OF POWDER SAMPLE DURING RHEOLOGICAL TESTING
An apparatus for performing electrical and rheological measurements of a powder sample includes an upper geometry including a first electrode, a lower geometry including a bottom surface and a second electrode, a sidewall forming a perimeter located between the upper geometry and the bottom surface of the lower geometry, a sample gap located between the upper geometry and the lower geometry and within the perimeter of the sidewall, the powder sample locatable in the sample gap such that the first electrode and the second electrode are in contact with the powder sample, an electrical measurement system operably connected to each of the first electrode and the second electrode configured to measure electrical properties of the powder sample during a rheological test, and a mechanical measurement system configured to measure mechanical properties of the powder sample located in the sample gap during the rheological test.
G01N 11/14 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane
70.
INTEGRATED AUTOMATED SAMPLE PREPARATION FOR THERMAL ANALYTICAL INSTRUMENTS
A method of automated sample preparation for thermal analysis includes picking up, with an automated gripping system of an autosampler, a pan located in a pan well of a sample tray; and performing an automated sample preparation procedure including at least one of: providing the pan to a balance module by the automated gripping system, wherein the balance module is configured to perform weight measurement on the pan; and providing the pan to a crimping module by the automated gripping system after a sample is loaded into the pan, wherein the crimping module is configured to seal the pan with an automated crimping process.
G01N 25/48 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
A sample tray for thermal analysis includes a tray body including a plurality of wells, wherein each well is configured to receive a sample pan and a sample lid. The sample pan is configured to receive a sample for thermal analysis, wherein the sample lid is configured to be crimped to the sample pan to create a seal between the sample lid and the sample pan, and the tray body is configured to be received into an automated sample preparation system to prepare samples for thermal analysis. A method of manufacturing a sample tray is also disclosed.
G01N 5/04 - Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid by removing a component, e.g. by evaporation, and weighing the remainder
G01N 25/00 - Investigating or analysing materials by the use of thermal means
72.
BATTERY CONTAINMENT DEVICES FOR THERMAL MEASUREMENTS
A battery material containment device comprises a lid; a housing case that is constructed and arranged to hold a battery material during a thermal analysis operation, the housing case including a threaded region for receiving and removably coupling with the lid to form a gas-tight seal and securing the battery material in the housing case; at least one vent for providing a gas flow path for the release of gasses generated by the battery material in the housing case during the thermal analysis operation; and a heat flow pathway between the battery material and a sensor that is maintained during the thermal analysis operation.
G01N 25/48 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
73.
BATTERY CONTAINMENT DEVICES FOR THERMAL MEASUREMENTS
A battery material containment device comprises a lid; a housing case that is constructed and arranged to hold a battery material during a thermal analysis operation, the housing case including a threaded region for receiving and removably coupling with the lid to form a gas-tight seal and securing the battery material in the housing case; at least one vent for providing a gas flow path for the release of gasses generated by the battery material in the housing case during the thermal analysis operation; and a heat flow pathway between the battery material and a sensor that is maintained during the thermal analysis operation.
H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells
H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte
09 - Scientific and electric apparatus and instruments
Goods & Services
Chromatography columns for laboratory use; chromatography
columns for use in a laboratory in connection with liquid
chromatography and mass spectrometry instruments; liquid
chromatography apparatus and mass spectrometry apparatus
incorporating cartridges, vials, and plates; analytical
equipment and instruments, namely, liquid chromatography and
mass spectrometry apparatuses for laboratory use, for
performing biological and chemical separations,
purification, screening and identification for medical
laboratory, clinical laboratory, and scientific laboratory
use and replacement parts therefor; chromatography apparatus
for laboratory use and replacement parts therefor;
spectrometry apparatus for laboratory use and replacement
parts therefor.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
Chemicals for liquid chromatography, namely chemical reagents, filler and columns. Chromatography columns; Chromatography columns for use in connection with liquid chromatography and mass spectrometry instruments.
09 - Scientific and electric apparatus and instruments
Goods & Services
Robotic imaging apparatus for analyzing and characterizing particulates; Robotic imaging apparatus for analyzing cells, proteins, antibodies, DNA, RNA, viral vectors, capsids, lipid nanoparticles, exosomes, and therapeutic applications thereof; Robotic imaging apparatus for particle analysis in protein, cell, and gene therapy formulations; Robotic imaging apparatus for quality control and stability testing of pharmaceutical and biopharmaceutical products; Robotic imaging apparatus for detecting, measuring, and characterizing particulate contamination, viral vector aggregation, viral vector stability, viral vector formulations, excipient degradation, and cell viability; Laboratory imaging instruments for analyzing and characterizing particulates; Laboratory imaging instruments for analyzing cells, proteins, antibodies, DNA, RNA, viral vectors, capsids, lipid nanoparticles, exosomes, and therapeutic applications thereof; Laboratory imaging instruments for particle analysis in protein, cell, and gene therapy formulations; Laboratory imaging instruments for quality control and stability testing of pharmaceutical and biopharmaceutical products; Laboratory imaging instruments for detecting, measuring, and characterizing particulate contamination, viral vector aggregation, viral vector stability, viral vector formulations, excipient degradation, and cell viability; Downloadable computer operating software for laboratory imaging instruments and robotic imaging apparatus; none of the foregoing including a spectrometer.
09 - Scientific and electric apparatus and instruments
Goods & Services
Chromatography columns for laboratory use; Chromatography columns for laboratory use in connection with liquid chromatography and mass spectrometry instruments
09 - Scientific and electric apparatus and instruments
Goods & Services
Robotic imaging apparatus for analyzing and characterizing particulates; Robotic imaging apparatus for analyzing cells, proteins, antibodies, DNA, RNA, viral vectors, capsids, lipid nanoparticles, exosomes, and therapeutic applications thereof; Robotic imaging apparatus for particle analysis in protein, cell, and gene therapy formulations; Robotic imaging apparatus for quality control and stability testing of pharmaceutical and biopharmaceutical products; Robotic imaging apparatus for detecting, measuring, and characterizing particulate contamination, viral vector aggregation, viral vector stability, viral vector formulations, excipient degradation, and cell viability; Laboratory imaging instruments for analyzing and characterizing particulates; Laboratory imaging instruments for analyzing cells, proteins, antibodies, DNA, RNA, viral vectors, capsids, lipid nanoparticles, exosomes, and therapeutic applications thereof; Laboratory imaging instruments for particle analysis in protein, cell, and gene therapy formulations; Laboratory imaging instruments for quality control and stability testing of pharmaceutical and biopharmaceutical products; Laboratory imaging instruments for detecting, measuring, and characterizing particulate contamination, viral vector aggregation, viral vector stability, viral vector formulations, excipient degradation, and cell viability; Downloadable computer operating software for laboratory imaging instruments and robotic imaging apparatus; none of the foregoing including a spectrometer
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Recorded or downloadable software for collecting,
manipulating, analyzing, storing, and reporting data in
chromatography and mass spectrometry applications; recorded
or downloadable software for collecting, manipulating,
analyzing, storing, and reporting data for laboratory use;
recorded or downloadable software for laboratory analytical
method development, testing, and validation management;
recorded or downloadable software for managing laboratory
workflow; recorded or downloadable software for purification
of samples in chromatography and spectrometry applications;
recorded or downloadable software for automating
chromatography and mass spectrometry operations; recorded or
downloadable software for laboratory and sample management;
recorded or downloadable software for chromatography and
spectrometry instruments; recorded or downloadable software
for an application programming interface (API) for
laboratory instruments; recorded or downloadable software
for quality assurance and quality control (QA/QC) of
pharmaceuticals, biopharmaceuticals, drugs, medicines,
supplements, nutraceuticals, foods, beverages, clinical
diagnostic products, cosmetics, personal care products,
electronics, and medical devices; recorded or downloadable
software for quality assurance and quality control (QA/QC)
of chemical compositions; recorded or downloadable software
for controlling data integrity for compliance with
government and industry regulation; recorded or downloadable
software for environmental regulation compliance testing;
recorded or downloadable software for managing compliance
with government and industry regulations; recorded or
downloadable software for electronic record keeping for
quality assurance and quality control (QA/QC) testing;
recorded or downloadable software for laboratory instrument
management, reagent management, column management, and
sample management; analytical equipment and instruments, not
for medical use, for performing biological and chemical
separation, purification, screening and identification,
namely, liquid chromatography apparatus and instruments for
laboratory use and structural parts and structural fittings
therefor for laboratory use; chromatography instruments
apparatus for laboratory use; chromatography instruments for
use in connection with mass spectrometry instruments for
laboratory use; chromatography instruments for use in
connection with laboratory analytical software;
chromatographic systems comprising of pumps, detectors,
injectors, autosamplers, gradient controllers, mixing
chambers, columns, recorders and fraction collectors for
laboratory use; laboratory instruments for processing
samples with liquid chromatography columns; analytical
laboratory instruments for automating sample analyses,
diluting samples, tracking and tracing results of sample
processing. Software as a service, or providing online software for
collecting, manipulating, analyzing, storing, and reporting
data in chromatography and mass spectrometry applications;
software as a service, or providing online software for
collecting, manipulating, analyzing, storing, and reporting
data for laboratory use; software as a service, or providing
online software for laboratory analytical method
development, testing, and validation management; software as
a service, or providing online software for managing
laboratory workflow; software as a service, or providing
online software for automating chromatography and mass
spectrometry operations; software as a service, or providing
online software for laboratory and sample management;
software as a service, or providing online software for
chromatography and spectrometry instruments; software as a
service, or providing online software for an application
programming interface (API) for laboratory instruments;
software as a service, or providing online software for
quality assurance and quality control (QA/QC) of
pharmaceuticals, biopharmaceuticals, drugs, medicines,
supplements, nutraceuticals, foods, beverages, clinical
diagnostic products, cosmetics, personal care products,
electronics, and medical devices; software as a service, or
providing online software for quality assurance and quality
control (QA/QC) of chemical compositions; software as a
service, or providing online software for controlling data
integrity for compliance with government and industry
regulation; software as a service, or providing online
software for environmental regulation compliance testing;
software as a service, or providing online software for
managing compliance with government and industry
regulations; software as a service, or providing online
software for electronic record keeping for quality assurance
and quality control (QA/QC) testing; software as a service,
or providing online software for laboratory instrument
management, reagent management, column management, and
sample management; services for updating and maintenance of
laboratory instrument and laboratory management computer
software; technical support services, namely,
troubleshooting of laboratory computer software problems;
technical support services, namely, operational
qualification services for scientific analytical apparatus
and instruments, specifically, technical verification and
validation of laboratory equipment; providing technical
advice relating to use, operation, and function of
scientific analytical apparatus and instruments; providing
temporary use of non-downloadable cloud-based software for
collecting, manipulating, analyzing, and storing data for
laboratory use, laboratory sample management, and for
laboratory analytical method development, testing, and
validation; consultation services relating to computer
software; consultation about the maintenance and updating of
computer software; providing technical advice relating to
the operation of computer software for pharmaceutical
regulation compliance, quality control, and testing;
consulting services in the field of compliance with
government and industry regulated laboratory testing
requirements; consulting services in the field of quality
assurance and quality control (QA/QC) of pharmaceuticals,
biopharmaceuticals, drugs, medicines, supplements,
nutraceuticals, foods, beverages, clinical diagnostic
products, cosmetics, personal care products, electronics,
and medical devices; consulting services in the field of
quality assurance and quality control (QA/QC) of chemical
compositions; consulting services in the field of technical
validation and verification of laboratory instruments;
software as a service, or providing online software for
purification of samples in chromatography and spectrometry
applications.
Disclosed is a liquid chromatography system and mixer for use therein that includes a first split connected to an inlet, the first split branching the flow of fluid from the inlet into a first path and a second path; a second split connected to an outlet of the first path, the second split branching the first path into a third path and a fourth path; and a third split connected to an outlet of the second path, the third split branching the second path into a fifth path and a sixth path. The first path and the second path are offset by a first predetermined volume, the third path and the fourth path are offset by a second predetermined volume, and the fifth path and the sixth path are also offset by the second predetermined volume.
Disclosed herein are methods of mapping a sequence of an RNA molecule comprising the steps of hybridizing a protecting primer with a portion the RNA molecule to form RNA/primer hybrid, combining the RNA molecule, the primer, and a digestion assay, digesting the RNA molecule hybridized with the primer in the digestion assay, and analyzing the two or more RNA fragments using liquid chromatography–mass spectrometry to determine the sequence of nucleotides in the RNA molecule. Also disclosed herein are digestion assays for selectively cleaving an RNA molecule into two or more RNA fragments.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical test kits for indicating the presence or absence of
toxins; chemical and biochemical reagents for non-medical
purposes for indicating the presence or absence of toxins;
chemically treated non-medical test strips for indicating
the presence or absence of toxins; reagents for laboratory
use; reagents for scientific and research use; analytical
standard solutions and reagents for scientific and research
use; analytical standard solutions and reagents for testing
soil for the purpose of monitoring contaminants;
chromatography chemicals; sample preparation kits for
scientific and research purposes, comprising biological
standards, namely, monoclonal antibodies, and chemical
reagents for biological analysis; chemical reagents for
preparing samples for chromatography and mass spectrometry
for non-medical, laboratory use; chemicals, namely, buffers
and standard solutions used in analytical chemistry; buffers
in the nature of chemicals used in analytical chemistry;
chemically-treated non-medical test strips and test-strip
holders specifically adapted for, and sold with, the
aforementioned test strips for the detection of mycotoxins
by antibody affinity reactions in grain, feed, and food
products; assay kits comprising an affinity chromatography
column and chemical reagents for testing for mycotoxin
contamination in grain, feed, and food products;
environmental quality control fluid, gas, and soil samples
for calculating standards for testing and verifying the
quality of soil and air. Analytical apparatus and instruments for laboratory use and
their parts, fittings, and accessories therefor; analytical
apparatus and instruments for performing biological testing,
physical testing, biological and chemical separation,
purification, screening and identification; laboratory
instruments, namely, chromatography and spectrometry
instruments for laboratory use; material testing laboratory
instruments; laboratory apparatus and instruments for solid
phase extraction; positive pressure manifolds for
chromatography instruments; laboratory analytical
instruments for detecting and measuring visual and
ultraviolet light; laboratory analytical instruments for
detecting and measuring fluorescence; laboratory analytical
instruments, namely, ultraviolet and visual light sensors;
laboratory analytical instruments, namely, photodiode array
sensors; laboratory analytical instruments, namely,
evaporative light scattering detectors; laboratory
analytical instruments, namely, refractive index detectors;
analytical instruments featuring light-guiding flow cell for
performing and analyzing biological and chemical samples,
not for medical use; wheeled carts specially adapted for
laboratory instruments; laboratory instruments for
organizing, storing, and processing laboratory samples in a
temperature controlled environment; fluid temperature
control system for laboratory use and scientific purposes;
laboratory instrument for controlling sample temperature;
laboratory instrument for controlling sample temperature for
use in connection with laboratory automation systems;
laboratory instruments for processing samples with liquid
chromatography columns; laboratory instruments for heating
and cooling laboratory samples and chromatography columns;
chromatography columns for laboratory use featuring radio
frequency identification (RFID) transponders; radio
frequency identification (RFID) transponders and readers for
use with chromatography columns; radio frequency radio
frequency identification (RFID) transponders, tags, labels,
and stickers sold as components of a chromatography column;
analytical laboratory instruments for automating sample
analyses, diluting samples, tracking and tracing results of
sample processing; spectral detectors for use in connection
with mass spectrometers and liquid chromatographs not for
medical use; detectors for detecting and quantifying
ultraviolet and visible spectral exposure for laboratory
use; florescence detectors for analysis and detection of
samples containing chemiluminescent properties for
laboratory use; laboratory robots; laboratory robots used
for the purpose of handling laboratory pipettes; laboratory
pipettes; automated laboratory pipettes; electronic
laboratory pipettes; automated pipetting instrument for
laboratory use for use in connection with liquid
chromatography or mass spectrometry; pipette racks for
laboratory use; pipette tips for laboratory use; pipette
accessories, namely, magnetic beads used for laboratory use
for DNA and RNA extraction within pipette tips; laboratory
equipment and apparatus, namely, magnetic beads for
laboratory use for use in purifying genomic, plasmid and
mitochondrial DNA; accessories for analytical apparatus and
instruments for scientific and laboratory research purposes,
namely, peltier plates in the nature of electrical cooling
and heating plates for cooling and heating laboratory
samples; laboratory equipment, namely, orbital shakers for
laboratory use; automated laboratory sample extraction
instruments comprised of vacuum control valves and alignment
posts; laboratory equipment and apparatus, namely, column
tube grippers and microplate grippers for transfer of
centrifuge tubes and microplates; laboratory equipment and
supplies, namely, microfluidic chips for analyzing RNA and
DNA; magnetic blocks for holding, organizing, agitating,
stirring, heating, cooling, and storing consumables for
laboratory use; laboratory equipment and supplies, namely,
glass bottles, tanks, tubes, vials, and caps for tubes for
laboratory use; laboratory equipment and supplies, namely,
plastic tubes and bottles for laboratory use; plates for
collecting and analyzing samples, namely, optimization
plates, elution plates, photoredox plates, and well plates
having multi-well arrays that can be used in chemical
analysis, biological analysis or patterning for scientific
or laboratory research use; non-medical immunostaining racks
for scientific or laboratory purposes; disposable reusable
dispenser syringes for laboratory sample use, not for
medical use; laboratory instrument for measuring and
locating the liquid levels of consumables for laboratory use
in the nature of liquid level sensors; computer hardware for
laboratory, scientific, and clinical use for use in managing
laboratory operations and analyzing laboratory samples;
electronic measurement systems, namely light scattering
photometers, differential refractometers, online particle
fractionators for use with light scattering photometers,
sonication (non-chemical) optical flow cell cleaners;
laboratory apparatus and instruments, namely multi-angel
light scattering instruments; laboratory apparatus and
instruments, namely dynamic light scattering instruments;
laboratory apparatus and instruments, namely electrophoretic
light scattering instruments; laboratory apparatus and
instruments, namely field-flow fractionation instruments;
laboratory analytical instruments for measuring and
characterizing molecular molar mass, molecular size,
molecular charge, molecular interaction, molecular shape and
confirmation, and molecular conjugation and bonding;
computer laboratory workstations comprised of downloadable
and recorded software for scientific, clinical, and
diagnostic laboratory use, namely, for use in managing
laboratory operations, analyzing laboratory samples, and
automating laboratory experiments; downloadable or recorded
application programming interface (API) software;
downloadable or recorded software for analyzing materials by
measuring changes in the physical or chemical properties of
the material as the material is subjected to controlled
changes in ITS environment; downloadable or recorded
software for analyzing samples for compliance with
environmental regulations; downloadable or recorded software
for analyzing samples for toxins or contaminants;
downloadable or recorded software for automating
chromatography and mass spectrometry operations in a
chromatography and mass spectrometry apparatus; downloadable
or recorded software for automating laboratory instruments;
downloadable or recorded software for automating pipetting;
downloadable or recorded software for calibrating pipettes;
downloadable or recorded software for collecting, analyzing,
organizing, storing, and reporting data for use in
scientific analysis; downloadable or recorded software for
collecting, analyzing, organizing, storing, and reporting
chromatography and mass spectrometry data; downloadable or
recorded software for collecting, analyzing, organizing,
storing, and reporting data from analytical equipment in the
chemical, pharmaceutical, life sciences, environmental,
clinical diagnostic, food science and safety, and forensic
toxicology fields; downloadable or recorded software for
controlling chromatography and spectrometry instruments;
downloadable or recorded software for controlling laboratory
instruments; downloadable or recorded software for creating
and executing laboratory methods and protocols; downloadable
or recorded software for data analysis for laboratory
instruments and laboratory data; downloadable or recorded
software for facilitating laboratory compliance with
government regulation; downloadable or recorded software for
identifying and analyzing the components of a sample;
downloadable or recorded software for laboratory analytical
method development, testing, and validation management,
namely, for creating, testing, and validating methods for
using analytical instruments for laboratory use;
downloadable or recorded software for laboratory and
laboratory sample management; downloadable or recorded
software for laboratory informatics; downloadable or
recorded software for laboratory robot control; downloadable
or recorded software for laboratory, scientific, and
clinical use, namely, computer software for use in managing
laboratory operations and analyzing laboratory samples;
downloadable or recorded software for managing laboratory
workflow, namely, software for controlling, organizing, and
tracking laboratory testing projects, laboratory test
results, laboratory staff utilization, and reagent and
sample inventories; downloadable or recorded software for
operating laboratory instruments; downloadable or recorded
software for purification of samples in chromatography and
spectrometry applications; downloadable or recorded software
for use in connection with light scattering and refractive
index detection, data acquisition applications, and liquid
chromatographic separations; downloadable or recorded
software for validating pipette performance; downloadable or
recorded software for validating processes in chromatography
and mass spectrometry laboratories; downloadable or recorded
software for validating processes in laboratories;
analytical apparatus and instruments for performing
biological testing, physical testing, biological and
chemical separation, purification, screening and
identification and structural parts and structural fittings
therefor, namely, liquid chromatography apparatus and
instruments for laboratory use and structural parts and
structural fittings therefor, gas chromatography apparatus
for laboratory use and structural parts and structural
fittings therefor, ION mobility chromatography apparatus for
laboratory use and structural parts and structural fittings
therefor, mass spectrometry apparatus and instruments for
laboratory use and structural parts and structural fittings
therefor; analytical apparatus and instruments, namely,
detectors for indicating the presence or absence of toxins
in the fields of agriculture and food processing and
structural parts and structural fittings therefor;
analytical apparatus and instruments for laboratory use,
namely, magnetic suspension balances and structural parts
and structural fittings therefor; analytical apparatus and
instruments for laboratory use, namely, mechanical testing
instruments, rubber testing instruments and structural parts
and structural fittings therefor; scientific analytical
apparatus and instruments in the nature of magnetic
suspension balances for isothermal measuring equilibrium and
kinetics of ad-or absorption processes and for
thermogravimetric measurements at high temperatures and high
pressures, gravimetric analysis, thermogravimetric analysis
or sorption analysis and structural parts and structural
fittings therefor; analytical apparatus and instruments for
laboratory use for gas and vapor dosing, mixing, and
pressure control and structural parts and structural
fittings therefor; analytical apparatus and instruments for
laboratory use, namely, electrosurgical instruments used
with analytical instruments to identify the presence or
absence of toxins in sample tissues, electrosurgical smoke
evaluation devices, devices for identification of chemicals
in electrosurgical smoke for non-medical diagnostic and
analytical purposes; fluorometers and structural parts and
structural fittings therefor; lateral flow readers and
structural parts and structural fittings therefor;
rheometers and structural parts and structural fittings
therefor; calorimeters and structural parts and structural
fittings therefor; dilatometers and structural parts and
structural fittings therefor; laboratory chemical reactors;
diagnostic apparatus for testing food; diagnostic apparatus
for testing agricultural products; diagnostic apparatus for
the detection and identification of microbes and pathogens
for laboratory or research use; diagnostic apparatus for
testing for illegal drugs, diagnostic apparatus for forensic
toxicology; chromatography columns for laboratory use;
laboratory consumables, namely, vials, containers, sample
trays, sample plates, sample containers, tubing, cartridges,
pipettes; solid phase extraction cartridges and plates for
laboratory use; affinity columns, comprising monoclonal
antibodies, for purifying samples for subsequent
liquid-chromatography and mass-spectrometry testing for
mycotoxin contamination in grain, feed, and food products;
computer operating software for analytical apparatus and
instruments; computer operating software for analyzing
materials by measuring changes in the physical or chemical
properties of the materials; computer operating software for
bioinformatics, laboratory data analysis, analysis and
visualization of data from liquid chromatography and mass
spectrometry instruments, discovery, identification, and
analysis of chemical compounds; computer operating software
for analyzing materials by measuring changes in the physical
or chemical properties of the material as the material is
subjected to controlled changes in ITS environment;
analytical apparatus and instruments for laboratory use,
namely, flash diffusivity analyzers and parts thereof;
mechanical testing instruments, for testing the mechanical
or material properties of test samples; mass spectrometer
and parts thereof; analytical apparatus and instruments for
analyzing mechanical or material properties of material
samples for scientific research purposes, namely, thermal
analyzers, thermal conductivity meters; laboratory
instruments, namely, specimen testing instruments used to
apply cyclic and static loads to a specimen integrated with
a controller used for fatigue testing and material testing
of the specimen subjected to loads; rheometers for measuring
the viscosity and viscoelasticity of fluids, and parts and
therefor; laboratory chemical reactors and parts thereof;
laboratory instruments, namely, autosamplers; laboratory
instruments, namely, pressure cells in the nature of vessels
that can withstand high internal pressures; computer
operating software for analyzing materials by measuring
changes in the physical or chemical properties of the
material as the material is subjected to controlled changes
in ITS environment; accessories for use with analytical
apparatus and instruments for scientific research purposes,
namely, grips and platens, stent and graft testers,
cylinders, equipment for cutting specimens, and temperature
control units; accessories for analytical apparatus and
instruments for scientific research purposes, namely,
peltier plate systems in the nature of electrical heating
and cooling plates, plate pressure cells in the nature of
vessels that can withstand high internal pressures, sensors
for sensing the mechanical and material properties of
samples, temperature, pressure, motion, distances, force,
torque, viscosity, elasticity, material strain, tension,
deflection, compression, electrically heated cylinders in
the nature of test chambers, relative humidity sensors,
optical plates, modular microscope accessory in the nature
of microscopes, environmental test chambers, namely,
temperature simulation equipment, small angle light
scattering diodes, interfacial rheology accessories, namely,
accessories for analyzing viscoelasticity, tribo-rheometry
accessories, namely, accessories for analyzing friction,
magneto-rheology accessories, namely, accessories for
analyzing properties of materials subject to magnetic
fields, electro-rheology accessories, namely, accessories
for analyzing properties of materials subject to electric
currents, UV curing accessories, namely, accessories for
analyzing properties of materials subject to ultraviolet
radiation, dieletric measurement accessories, namely,
accessories for analyzing properties of materials subject to
an oscillating electrical field, diaelectric thermal
analysis accessories, namely, accessories for analyzing
properties of materials subject to controlled temperatures
and an oscillating electrical field, immobilization cells,
namely, test chambers for characterizing the drying,
retention, and immobilization kinetics of paints, coatings,
and slurries; starch pasting cells, namely, test chambers
for analyzing starches, dynamic mechanical analysis
accessories, namely, accessories for analyzing material
properties of solid materials, refrigerated cooling systems,
namely, analytical instrument accessories for controlling
sample temperature, laboratory instruments, namely,
autosamplers and automated sample processing apparatus and
carousels, forced convection oven accessories, namely,
analytical instrument accessories for controlling sample
temperature, orthogonal superposition accessories, namely,
accessories for analyzing nonlinear viscoelasticity,
2-dimensional small amplitude oscillatory shear accessories,
namely, accessories for analyzing nonlinear viscoelasticity,
extensional viscosity fixture accessories, namely,
accessories for analyzing extensional viscosity and stress,
cone and partitioned plate accessories, namely, accessories
for analyzing elastic materials, interfacial rheology
accessories, degassing stations, namely, instruments for
removing gasses from samples, clamps for use with analytical
instruments, evacuated ampoules made of glass, metal, or
plastic for use in testing and analyzing samples for
non-medical purposes, sample measuring system accessories,
namely, accessories for measuring the mechanical and
material properties of samples, temperature, pressure,
motion, distances, force, torque, viscosity, elasticity,
material strain, tension, deflection, compression. Promoting the exchange of information and resources within
the laboratory research community to achieve advances in the
field of the separation sciences; promoting the exchange of
information and resources within the laboratory research
community to achieve advances in the fields of chemistry,
biochemistry, pharmaceuticals, environmental science,
material science, and material characterization; business
consulting services in best practices for laboratory
research in the field of chemistry, biochemistry
pharmaceutical science, forensic toxicology, food science,
environmental science, material science, and material
characterization; online, catalog, and mail order services
featuring computer operating software for analytical
apparatus and instruments, analyzing and manipulating data;
online, catalog, and mail order services featuring computer
operating software data acquisition, processing, and
reporting. Providing facilities for scientific research in the nature
of a laboratory for the separation sciences; providing
facilities for scientific research in the nature of a
laboratory featuring instruments for chromatography, mass
spectrometry, and material science; consulting services in
the field of laboratory research for chemistry,
biochemistry, pharmaceutical science, material science, and
material characterization; consulting services in the field
of laboratory science; technical consulting services in best
practices for laboratory research in the field of chemistry,
biochemistry pharmaceutical science, material science and
material characterization; scientific research and
development; laboratory study and research in the fields of
chemistry, biochemistry, pharmaceutical science, material
science, and material characterization; scientific
laboratory research services in the field of chemistry,
biochemistry pharmaceutical science, material science and
material characterization; research and development of
laboratory instruments in the field of chemistry,
biochemistry pharmaceutical science, material science, and
material characterization; advisory services relating to the
fields of development of laboratory instruments in the field
of chemistry, biochemistry pharmaceutical science, material
science, and material characterization advisory services
related to material testing; updating, repair, and
maintenance of laboratory software; technical support
services, namely, providing information, consultation and
diagnostic services in the fields of electronic and optical
components, computer software, and scientific, electronic
test, measurement, biological and chemical analytical, and
optical equipment; services for updating and maintenance of
laboratory instrument and laboratory management computer
software; technical support services, namely,
troubleshooting of laboratory computer software problems;
technical support services, namely, operational
qualification services for scientific analytical apparatus
and instruments, specifically, technical verification and
validation of laboratory equipment; providing technical
advice relating to use, operation, and function of
scientific analytical apparatus and instruments; software as
a service (SaaS) services featuring software for analyzing
materials by measuring changes in the physical or chemical
properties of the material as the material is subjected to
controlled changes in ITS environment software as a service
(SaaS) services featuring software for analyzing samples for
compliance with environmental regulations; software as a
service (SaaS) services featuring software for analyzing
samples for toxins or contaminants; software as a service
(SaaS) services featuring software for automating
chromatography and mass spectrometry operations in a
chromatography and mass spectrometry apparatus; software as
a service (SaaS) services featuring software for automating
laboratory instruments; software as a service (SaaS)
services featuring software for automating pipetting;
software as a service (SaaS) services featuring software for
calibrating pipettes; software as a service (SaaS) services
featuring software for collecting, analyzing, organizing,
storing, and reporting data for use in scientific analysis;
software as a service (SaaS) services featuring software for
collecting, analyzing, organizing, storing, and reporting
chromatography and mass spectrometry data; software as a
service (SaaS) services featuring software for collecting,
analyzing, organizing, storing, and reporting data from
analytical equipment in the chemical, pharmaceutical, life
sciences, environmental, clinical diagnostic, food science
and safety, and forensic toxicology fields; software as a
service (SaaS) services featuring software for controlling
chromatography and spectrometry instruments; software as a
service (SaaS) services featuring software for controlling
laboratory instruments; software as a service (SaaS)
services featuring software for creating and executing
laboratory methods and protocols; software as a service
(SaaS) services featuring software for data analysis for
laboratory instruments and laboratory data; software as a
service (SaaS) services featuring software for facilitating
laboratory compliance with government regulation; software
as a service (SaaS) services featuring software for
identifying and analyzing the components of a sample;
software as a service (SaaS) services featuring software for
laboratory analytical method development, testing, and
validation management, namely, for creating, testing, and
validating methods for using analytical instruments for
laboratory use; software as a service (SaaS) services
featuring software for laboratory and laboratory sample
management; software as a service (SaaS) services featuring
software for laboratory informatics; software as a service
(SaaS) services featuring software for laboratory robot
control; software as a service (SaaS) services featuring
software for laboratory, scientific, and clinical use,
namely, computer software for use in managing laboratory
operations and analyzing laboratory samples; software as a
service (SaaS) services featuring software for managing
laboratory workflow, namely, software for controlling,
organizing, and tracking laboratory testing projects,
laboratory test results, laboratory staff utilization, and
reagent and sample inventories; software as a service (SaaS)
services featuring software for operating laboratory
instruments; software as a service (SaaS) services featuring
software for purification of samples in chromatography and
spectrometry applications; software as a service (SaaS)
services featuring software for use in connection with light
scattering and refractive index detection, data acquisition
applications, and liquid chromatographic separations;
software as a service (SaaS) services featuring software for
validating pipette performance; software as a service (SaaS)
services featuring software for validating processes in
chromatography and mass spectrometry laboratories; software
as a service (SaaS) services featuring software for
validating processes in laboratories; providing online,
non-downloadable software for analyzing materials by
measuring changes in the physical or chemical properties of
the material as the material is subjected to controlled
changes in ITS environment; providing online,
non-downloadable software for analyzing samples for
compliance with environmental regulations; providing online,
non-downloadable software for analyzing samples for toxins
or contaminants; providing online, non-downloadable software
for automating chromatography and mass spectrometry
operations in a chromatography and mass spectrometry
apparatus; providing online, non-downloadable software for
automating laboratory instruments; providing online,
non-downloadable software for automating pipetting;
providing online, non-downloadable software for calibrating
pipettes; providing online, non-downloadable software for
collecting, analyzing, organizing, storing, and reporting
data for use in scientific analysis; providing online,
non-downloadable software for collecting, analyzing,
organizing, storing, and reporting chromatography and mass
spectrometry data; providing online, non-downloadable
software for collecting, analyzing, organizing, storing, and
reporting data from analytical equipment in the chemical,
pharmaceutical, life sciences, environmental, clinical
diagnostic, food science and safety, and forensic toxicology
fields; providing online, non-downloadable software for
controlling chromatography and spectrometry instruments;
providing online, non-downloadable software for controlling
laboratory instruments; providing online, non-downloadable
software for creating and executing laboratory methods and
protocols; providing online, non-downloadable software for
data analysis for laboratory instruments and laboratory
data; providing online, non-downloadable software for
facilitating laboratory compliance with government
regulation; providing online, non-downloadable software for
identifying and analyzing the components of a sample;
providing online, non-downloadable software for laboratory
analytical method development, testing, and validation
management, namely, for creating, testing, and validating
methods for using analytical instruments for laboratory use;
providing online, non-downloadable software for laboratory
and laboratory sample management; providing online,
non-downloadable software for laboratory informatics;
providing online, non-downloadable software for laboratory
robot control; providing online, non-downloadable software
for laboratory, scientific, and clinical use, namely,
computer software for use in managing laboratory operations
and analyzing laboratory samples; providing online,
non-downloadable software for managing laboratory workflow,
namely, software for controlling, organizing, and tracking
laboratory testing projects, laboratory test results,
laboratory staff utilization, and reagent and sample
inventories; providing online, non-downloadable software for
operating laboratory instruments; providing online,
non-downloadable software for purification of samples in
chromatography and spectrometry applications; providing
online, non-downloadable software for use in connection with
light scattering and refractive index detection, data
acquisition applications, and liquid chromatographic
separations; providing online, non-downloadable software for
validating pipette performance; providing online,
non-downloadable software for validating processes in
chromatography and mass spectrometry laboratories; providing
online, non-downloadable software for validating processes
in laboratories; design and development of analytical
apparatus and instruments and parts therefor for scientific
and research use; design and development of chemistry
consumables for laboratory use; design and development of
computer software for analytical apparatus and instruments
or scientific and research use; scientific consulting
services in the field of analytical chemistry; scientific
consulting services in the field of analytical chemistry in
the nature of product qualification and validation,
implementation project management of scientific research for
chemical analyses, computer software testing for chemical
analyses, laboratory analytics, and informatics for chemical
analyses; scientific consulting in the field of analytical
chemistry, namely, development of practical applications and
usage of laboratory apparatus and instruments for use in
research in analytical chemistry; cloud computing featuring
software and software as a service featuring software for
use with analytical apparatus and instruments in
bioinformatics, laboratory data analysis, analysis and
visualization of data from liquid chromatography and mass
spectrometry instruments, discovery, identification, and
analysis of chemical compounds, analyzing materials by
measuring changes in the physical or chemical properties of
the material as the material is subjected to controlled
changes in ITS environment; maintenance and repair services
for database systems and computer operating software.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Kits comprising reagents not for medical use, chemically-treated test strips and holders for test strips for the detection of mycotoxins in grain, feed, and food products; assay kits for detection of chemicals or toxins; assay kits for testing for mycotoxin contamination in grain, feed, and food products; assay kits for testing of chemicals or identifying toxins for laboratory use; chemical test kits for indicating the presence or absence of toxins for laboratory or research use; test strips for indicating the presence or absence of toxins; kits comprising monoclonal antibodies, buffers and reagents for use in the detection of chemicals or toxins for non-medical use; chemical reagents; reagents for detecting chemicals and toxins.
(2) Electronic detectors for indicating the presence or absence of toxins in the fields of agriculture and food processing; measuring devices, namely, fluorometers; lateral flow readers; chromatography columns for laboratory use; chromatography columns for detecting toxins not for medical use; chromatography columns for preparing samples for subsequent chromatography and mass-spectrometry testing; chromatography columns for subsequent chromatography and mass-spectrometry testing; laboratory apparatus for detecting toxins and chemicals not for medical use; electronic detectors for indicating the presence or absence of toxins in the fields of agriculture, animal feed, grains, foods and beverage, botanicals, and consumer products; affinity columns, comprising monoclonal antibodies, for purifying samples for subsequent liquid-chromatography and mass-spectrometry testing for mycotoxin contamination in grain, feed, and food products; prepacked affinity column for detecting chemicals and toxins. (1) Providing scientific and laboratory information regarding toxin and chemical testing; providing scientific and laboratory information regarding compliance with food, beverage, and agricultural testing regulations; providing online non-downloadable software for facilitating compliance with government regulation; providing laboratory testing information regarding toxin testing regulatory standards via an online database.
85.
INJECTION ELUTION METHODS FOR AFFINITY CHROMATOGRAPHY
The present disclosure is directed to methods of performing affinity chromatography. The injection elution methods disclosed herein afford rapid and robust elution of a target analyte from an affinity chromatography column, therefore improving workflow efficiency. Further, the single injection elution methods result in highly concentrated samples, mitigating the need for sample concentration or manipulation.
The present disclosure is directed to methods of performing direct affinity-size exclusion chromatography, wherein there is a direct elution of the sample from the affinity chromatography column to the SEC column. The methods described herein allow for rapid and robust purification of target analytes from heterogeneous samples, and mitigate the need for complicated valve switching, buffer exchange, or other sample manipulation.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
87.
DIRECT AFFINITY TO SIZE-EXCLUSION CHROMATOGRAPHY METHODS AND SYSTEMS THEREOF
The present disclosure is directed to methods of performing direct affinity-size exclusion chromatography, wherein there is a direct elution of the sample from the affinity chromatography column to the SEC column. The methods described herein allow for rapid and robust purification of target analytes from heterogeneous samples, and mitigate the need for complicated valve switching, buffer exchange, or other sample manipulation.
B01D 15/34 - Size-selective separation, e.g. size-exclusion chromatographyGel filtrationPermeation
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
B01J 20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
88.
HOST CELL PROTEIN DETECTION USING LATERAL FLOW DEVICES
Time sensitive biopharmaceutical processing updates can be implemented using lateral flow devices to test on-site during manufacturing. Lateral flow testing for an analyte such as, for example, impurities (e.g., host cell proteins), during manufacturing of a biopharmaceutical drug product is completed within twenty-five minutes of collecting a sample from the manufacturing line. That is, all sample preparation, such as adding reagent or diluting the sample, contacting the prepared sample to a lateral flow device, and detecting presence or absence of the analyte is completed within twenty-five minutes (e.g., 20 minutes, 18 minutes, 15 minutes) from collection such that processing adjustments during manufacturing can be implemented.
A device for removal of excess material from a test sample includes a test geometry comprising a lower geometry and an upper geometry, wherein at least one of the upper geometry and the lower geometry is configured to move vertically with respect to the other of the upper geometry and the lower geometry and a trimming device. The trimming device includes a first arm extending to a first set of blades including a first blade and a second blade, a second arm extending to a second set of blades including a third blade and a fourth blade, and linear track system. Movement of the trimming device along the linear track system first engages the first blade and the third blade with an exterior of at least one of the upper geometry and the lower geometry, and then engages the second blade and the fourth blade with the exterior of the at least one of the upper geometry and the lower geometry.
Time sensitive biopharmaceutical processing updates can be implemented using lateral flow devices to test on-site during manufacturing. Lateral flow testing for an analyte such as, for example, impurities (e.g., host cell proteins), during manufacturing of a biopharmaceutical drug product is completed within twenty-five minutes of collecting a sample from the manufacturing line. That is, all sample preparation, such as adding reagent or diluting the sample, contacting the prepared sample to a lateral flow device, and detecting presence or absence of the analyte is completed within twenty-five minutes (e.g., 20 minutes, 18 minutes, 15 minutes) from collection such that processing adjustments during manufacturing can be implemented.
The present disclosure is directed to methods of performing affinity chromatography. The injection elution methods disclosed herein afford rapid and robust elution of a target analyte from an affinity chromatography column, therefore improving workflow efficiency. Further, the single injection elution methods result in highly concentrated samples, mitigating the need for sample concentration or manipulation.
B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
92.
DEVICE AND METHOD FOR REMOVING EXCESS MATERIAL FROM A TEST SAMPLE
A device for removal of excess material from a test sample includes a test geometry comprising a lower geometry and an upper geometry, wherein at least one of the upper geometry and the lower geometry is configured to move vertically with respect to the other of the upper geometry and the lower geometry and a trimming device. The trimming device includes a first arm extending to a first set of blades including a first blade and a second blade, a second arm extending to a second set of blades including a third blade and a fourth blade, and linear track system. Movement of the trimming device along the linear track system first engages the first blade and the third blade with an exterior of at least one of the upper geometry and the lower geometry, and then engages the second blade and the fourth blade with the exterior of the at least one of the upper geometry and the lower geometry.
G01N 11/14 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Kits comprising reagents not for medical use, chemically-treated test strips and holders for test strips for the detection of mycotoxins in grain, feed, and food products; Assay kits for detection of chemicals or toxins; Assay kits for testing for mycotoxin contamination in grain, feed, and food products; Assay kits for testing of chemicals or identifying toxins for laboratory use; Affinity columns, comprising monoclonal antibodies, for purifying samples for subsequent liquid-chromatography and mass-spectrometry testing for mycotoxin contamination in grain, feed, and food products; Chemical test kits for indicating the presence or absence of toxins for laboratory or research use; Test strips for indicating the presence or absence of toxins; Kits comprising monoclonal antibodies, buffers and reagents for use in the detection of chemicals or toxins for non-medical use; Prepacked affinity column and reagents for detecting chemicals and toxins; Chemical reagents Electronic detectors for indicating the presence or absence of toxins in the fields of agriculture and food processing; Measuring devices, namely, fluorometers; Lateral flow readers; Chromatography columns for laboratory use; Chromatography columns for detecting toxins not for medical use; Chromatography columns for preparing samples for subsequent chromatography and mass-spectrometry testing; Chromatography columns for subsequent chromatography and mass-spectrometry testing; Laboratory apparatus for detecting toxins and chemicals not for medical use; Electronic detectors for indicating the presence or absence of toxins in the fields of agriculture, animal feed, grains, foods and beverage, botanicals, and consumer products Providing scientific and laboratory information regarding toxin and chemical testing; Providing scientific and laboratory information regarding compliance with food, beverage, and agricultural testing regulations; Providing online non-downloadable software for facilitating compliance with government regulation; Providing access to an online database featuring laboratory information regarding toxin testing regulatory standards
94.
INSULATED SERIAL COLUMN CHROMATOGRAPHY ARRANGEMENTS AND SYSTEMS
Exemplary embodiments eliminate the need for column ovens in serial column chromatography arrangements and systems by using insulated sleeves. The insulated sleeves may encase individual chromatography columns or clusters of chromatography columns. The use of the insulated sleeves allows the chromatography columns to be positioned in close proximity to each other. This may decrease the overall size of a serial column chromatography arrangement and may reduce costs by not requiring the column ovens.
The present disclosure pertains to compositions comprising a non-porous particle core coated with a hydrophilic polymer with surface-grafted polyionic chains. In some aspects, the present disclosure pertains to chromatographic separation devices that comprise such compositions. In some further aspects, the present disclosure pertains to chromatographic methods that comprise: (a) loading a sample onto a chromatographic column comprising such compositions and (b) flowing a mobile phase through the column.
B01J 41/14 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01J 41/05 - Processes using organic exchangers in the strongly basic form
The present disclosure is directed to methods for characterization of a sample by size exclusion chromatography (SEC), the sample including intact lipid nanoparticles (LNPs). The method generally includes loading the sample on a chromatographic column having an SEC packing material disposed therein, flowing a mobile phase through the SEC packing material to elute the intact LNPs, and detecting the eluted intact LNPs. The mobile phase includes an aqueous buffer and a branched poly-α-d-glucoside.
The present disclosure is directed to methods for characterization of a sample by size exclusion chromatography (SEC), the sample including intact lipid nanoparticles (LNPs). The method generally includes loading the sample on a chromatographic column having an SEC packing material disposed therein, flowing a mobile phase through the SEC packing material to elute the intact LNPs, and detecting the eluted intact LNPs. The mobile phase includes an aqueous buffer and a branched poly-α-d-glucoside.
Exemplary embodiments may provide a pneumatic transfer system for transferring fluid samples from a bioreactor to sample processing system without the need for manual transfer of the fluid samples. The exemplary embodiments may transfer fluid samples distances of at least 1 foot with the pneumatic transfer system without substantial loss of the fluid samples. Exemplary embodiments may recover at least 50% of the mass of the fluid samples at the destination. Exemplary embodiments may choose the pressure applied by one or more pumps so as to be sufficient enough so as to move the fluid samples at a reasonable rate without causing fragmentation of the fluid samples that results in non-negligible portions of the fluid samples sticking to the inner walls of the conduit in small droplets.
Exemplary embodiments may provide a pneumatic transfer system for transferring fluid samples from a bioreactor to sample processing system without the need for manual transfer of the fluid samples. The exemplary embodiments may transfer fluid samples distances of at least 1 foot with the pneumatic transfer system without substantial loss of the fluid samples. Exemplary embodiments may recover at least 50% of the mass of the fluid samples at the destination. Exemplary embodiments may choose the pressure applied by one or more pumps so as to be sufficient enough so as to move the fluid samples at a reasonable rate without causing fragmentation of the fluid samples that results in non-negligible portions of the fluid samples sticking to the inner walls of the conduit in small droplets.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Recorded or downloadable software for collecting, manipulating, analyzing, storing, and reporting data in chromatography and mass spectrometry applications; recorded or downloadable software for collecting, manipulating, analyzing, storing, and reporting data for laboratory use; recorded or downloadable software for laboratory analytical method development, testing, and validation management; recorded or downloadable software for managing laboratory workflow; recorded or downloadable software for purification of samples in chromatography and spectrometry applications; recorded or downloadable software for automating chromatography and mass spectrometry operations; recorded or downloadable software for laboratory and sample management; recorded or downloadable software for chromatography and spectrometry instruments; recorded or downloadable software for an application programming interface (API) for laboratory instruments; recorded or downloadable software for quality assurance and quality control (QA/QC) of pharmaceuticals, biopharmaceuticals, drugs, medicines, supplements, nutraceuticals, foods, beverages, clinical diagnostic products, cosmetics, personal care products, electronics, and medical devices; recorded or downloadable software for quality assurance and quality control (QA/QC) of chemical compositions; recorded or downloadable software for controlling data integrity for compliance with government and industry regulation; recorded or downloadable software for environmental regulation compliance testing; recorded or downloadable software for managing compliance with government and industry regulations; recorded or downloadable software for electronic record keeping for quality assurance and quality control (QA/QC) testing; recorded or downloadable software for laboratory instrument management, reagent management, column management, and sample management; analytical equipment and instruments, not for medical use, for performing biological and chemical separation, purification, screening and identification, namely, liquid chromatography apparatus and instruments for laboratory use and structural parts and structural fittings therefor for laboratory use; chromatography instruments and apparatus for laboratory use; chromatography instruments for use in connection with mass spectrometry instruments for laboratory use; chromatography instruments for use in connection with laboratory analytical software; chromatographic systems comprising of pumps, detectors, injectors, autosamplers, gradient controllers, mixing chambers, columns, recorders and fraction collectors for laboratory use; laboratory instruments for processing samples with liquid chromatography columns; analytical laboratory instruments for automating sample analyses, diluting samples, tracking and tracing results of sample processing. Software as a service, or providing online software for collecting, manipulating, analyzing, storing, and reporting data in chromatography and mass spectrometry applications; software as a service, or providing online software for collecting, manipulating, analyzing, storing, and reporting data for laboratory use; software as a service, or providing online software for laboratory analytical method development, testing, and validation management; software as a service, or providing online software for managing laboratory workflow; software as a service, or providing online software for automating chromatography and mass spectrometry operations; software as a service, or providing online software for laboratory and sample management; software as a service, or providing online software for chromatography and spectrometry instruments; software as a service, or providing online software for an application programming interface (API) for laboratory instruments; software as a service, or providing online software for quality assurance and quality control (QA/QC) of pharmaceuticals, biopharmaceuticals, drugs, medicines, supplements, nutraceuticals, foods, beverages, clinical diagnostic products, cosmetics, personal care products, electronics, and medical devices; software as a service, or providing online software for quality assurance and quality control (QA/QC) of chemical compositions; software as a service, or providing online software for controlling data integrity for compliance with government and industry regulation; software as a service, or providing online software for environmental regulation compliance testing; software as a service, or providing online software for managing compliance with government and industry regulations; software as a service, or providing online software for electronic record keeping for quality assurance and quality control (QA/QC) testing; software as a service, or providing online software for laboratory instrument management, reagent management, column management, and sample management; services for updating and maintenance of laboratory instrument and laboratory management computer software; technical support services, namely, troubleshooting of laboratory computer software problems; technical support services, namely, operational qualification services for scientific analytical apparatus and instruments, specifically, technical verification and validation of laboratory equipment; providing technical advice relating to use, operation, and function of scientific analytical apparatus and instruments; providing temporary use of non-downloadable cloud-based software for collecting, manipulating, analyzing, and storing data for laboratory use, laboratory sample management, and for laboratory analytical method development, testing, and validation; consultation services relating to computer software; consultation about the maintenance and updating of computer software; providing technical advice relating to the operation of computer software for pharmaceutical regulation compliance, quality control, and testing; technical consulting services in the field of compliance with government and industry regulated laboratory testing requirements; consulting services in the field of quality assurance and quality control (QA/QC) of pharmaceuticals, biopharmaceuticals, drugs, medicines, supplements, nutraceuticals, foods, beverages, clinical diagnostic products, cosmetics, personal care products, electronics, and medical devices; consulting services in the field of quality assurance and quality control (QA/QC) of chemical compositions; consulting services in the field of technical validation and verification of laboratory instruments; software as a service, or providing online software for purification of samples in chromatography and spectrometry applications.
