Disclosed embodiments enable apparatus and methodologies that are provided for three-dimensional construction of tissues in the body at locations internal to the body.
Disclosed embodiments provide an apparatus and method that produce a magnetic field gradient configured to counteract effects of a static magnetic field such that the combination of the two fields may be applied to one or more magnetic particles to manipulate the magnetic particle(s). In accordance with at least one disclosed embodiment, application of the magnetic fields is used to focus the magnetizable particles in a particular location, for example, within a body part.
Disclosed embodiments enable determining and monitoring the location of at least one particle in a subject's body, as well as the status of a local environment within the body where the at least one particle is located.
An apparatus, and method of constructing such an apparatus, conducts and insulates materials with intervening coolant channels, wherein the conducting materials form an electromagnet. The coolant may be liquid nitrogen, and the apparatus may be an MRI, a generator, a transformer, an inductor heater, a motor, an automotive vehicle, an aerial vehicle, or maritime vehicle.
H01K 9/08 - Lamps having two or more incandescent bodies separately heated to provide selectively different light effects, e.g. for automobile headlamp
An apparatus and method apply magnetic fields by generators external to a body or body part with sensors within an in vivo source that are sensitive to applied magnetic fields Through the use of these applied magnetic fields and sensitive sensors, disclosed embodiments can realize much better spatial resolution than is conventionally possible.
An apparatus and method perform non-invasive lithium measurement of a patient wherein an apparatus comprising a permanent magnet, and at least one radiofrequency coil tuned to the resonant frequency of one or more isotopes of lithium are coupled to a cavity less than 5 cm in diameter in which a subject's body part (other than the subject's brain) can be inserted, wherein, the concentration of lithium in the subject's body is assessed based on one or more measurements of an amount of lithium detected in the body part without the need for withdrawing fluids from the body.
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G01R 33/465 - NMR spectroscopy applied to biological material, e.g. in vitro testing
G01R 33/36 - Electrical details, e.g. matching or coupling of the coil to the receiver
7.
APPARATUS AND METHOD FOR SPATIALLY SELECTIVE INTERVENTIONAL NEUROPARTICLES
An apparatus and method are provided for spatially-selective administration of actions by at least one device in the body using a transducer that is sensitive to a spatially-variant energy field imposed on the at least one device by a source external to a subject's body; and at least one component in the at least one device, wherein interaction of the transducer with the imposed spatially-variant energy field causes or enables at least one component in the at least one device to affect nearby tissues in the body.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
8.
METHOD AND APPARATUS FOR HIGH RESOLUTION PHYSIOLOGICAL IMAGING OF NEURONS
In accordance with disclosed embodiments, very high magnetic gradients and magnetic slew are applied to magnetizable particle imaging in order to realize high spatial resolution. A preferred method for describing the distribution of neurons in living tissue without causing unpleasant stimulation comprises: imposing a magnetic gradient on the tissue within a short transition time, and assessing the spatial distribution or orientation of previously introduced magnetizable particles with a spatial resolution better than 500 microns.
Magnetic gradients are used to transport Magnetic Nano Particles through a barrier, for example, the cribiform (also spelled "cribriform") plate, which is a porous bony structure which separates the nasal cavity from the cranial vault. By utilizing a configuration of magnets (whether of the electromagnetic type or permanent magnets), MNPs can be propelled, pushed, pulled or otherwise manipulated in relation to an anatomical and/or physiological barrier, to position, re-position or maintain the position(s) of the MNPs.
An apparatus and method direct nanoparticles in a body part under imaging guidance using at least one electromagnet configured and operable to create a magnetic field gradient used to direct the nanoparticles, wherein, the magnetic field gradient used to direct the nano-particles does not substantially interfere with the use of magnetic field gradients whose purpose is to image the body part.
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
An apparatus and a method for increasing the magnitude of the magnetic gradient for MRI without causing nerve stimulation. As an example, the short ramp time of magnetic gradients, for example less than 150 microseconds is contemplated. These short ramp-time magnetic gradients are used for the imaging of structures with short relaxations times, such as teeth, without causing nerve stimulation. The apparatus comprises a generator of magnetic gradients of at least 1 milliTeslas in magnitude with at least one gradient ramp time shorter than 150 microseconds and which induces no peripheral nerve stimulation.
An electromagnetic structure is fabricated by additive manufacturing having at least one channel traversing the structure. In one embodiment, at least one form contains apertures and/or holes forming the channel and a liquid metal traverses the structure by the channel. Electrodes are provided to apply or extract electrical voltage or power to and/or from the liquid metal as well as a mechanism for propelling a portion of the liquid metal through the form. In an alternative embodiment, both the electrically insulating and the electrically conductive materials are solid and the channel is used for conducting a coolant instead of the liquid metal.
A method and apparatus for performing computed tomography in medical imaging through reconstruction of a data set containing projections obtained during relative motions a container or body of interest with respect to an x-ray source and/or x-ray detector panel. Strobing of the data is implemented through one or more methods to include pulsing of the x-ray source, intermittent blanking of the x-ray detector panel, or intermittent processing of data collected from the detector panel to simulate blanking. The invention is utilized to significantly improve contrast by taking advantage of the pulsed nature of the source to implement three-dimensional reconstruction.
A method and apparatus for assessing the time since demise of one or more tissue components, comprising a source of radiation to generate excitatory radiation toward a tissue component, the tissue component generating responsive radiation in response to the excitatory radiation, a sensor to receive the responsive radiation from the tissue component and create a signal indicating the rate of change (over time) of the responsive radiation, a processor connected to the sensor to receive the signal from the sensor, and wherein the processor evaluates the received signal and provides information whereby a user can assess the time since demise of the tissue component based on responsive radiation generated by the tissue component as a result of excitation of at least one intrinsic tissue component metabolic product.
A magnetic field generator includes a power source and a segmented or un-segmented coil connected to the power source to generate a time-varying magnetic field. Energy is applied to the coil so that the coil generates a time-varying magnetic field gradient with a magnitude of at least 1 milliTesla per meter and a rise-time of less than 10 microseconds. The coil may be comprised of overlapping, non-overlapping or partially overlapping coil segments that may individually energized to further improve the operating characteristics of the coil to further decrease bio-effects in magnetic resonance imaging through the use of reduced pulse lengths and multi-phasic magnetic gradient pulses.
A method and apparatus generate a pre-polarizing magnetic field having a rise-time of less than about 10 microseconds and/or a fall-time of less than about 10 microseconds for immersing a tissue sample in the pre-polarized magnetic field to polarize an animal tissue sample whereby magnetic gradient and/or radio-frequency pulses may be applied in order to read out the location and/or state of the spins. A method and apparatus deliver such magnetic fields through planar coils. A method and apparatus enable guidance and propulsion of magnetic fluids.
A magnetic field generator includes a power source and a coil connected to the power source to generate a time-varying magnetic field. Energy is applied to the coil so that the coil generates a time-varying magnetic field gradient with a magnitude of at least 1 milliTesla per meter and a rise-time of less than 10 microseconds. One or more of a capacitor, a multi-stage high-voltage switch, and/or a pulse-forming network may assist with the generation of the magnetic field gradient.
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