Abstract

A compound represented by Chemical Formula 1, an organic electronic component or a light-emitting layer including same, an OLED including the light-emitting layer, and a device comprising the OLED are provided: A compound represented by Chemical Formula 1, an organic electronic component or a light-emitting layer including same, an OLED including the light-emitting layer, and a device comprising the OLED are provided: wherein in Chemical Formula 1, R1 to R4, n1 and n2, and X1 to X9 are the same as defined in the specification.

IPC Classes  ?

• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H10K 50/11 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers
• H10K 85/30 - Coordination compounds

Abstract

A method for preparing a reduction catalyst for water electrolysis using protective coating; a reduction electrode for alkaline water electrolysis comprising a reduction catalyst prepared thereby, and an alkaline water electrolysis system are disclosed. The method for preparing a reduction catalyst for water electrolysis applies a protective coating method and suppresses the growth of alloy particles in a subsequent high-temperature heat treatment step, and, thus, can prepare and provide a catalyst with a high alloying degree. As a result, a non-novel metal alloy catalyst prepared according to the method of the present invention has excellent catalytic characteristics by exhibiting hydrogen evolution reaction (HER) performance similar to that of platinum, which is a noble metal catalyst.

IPC Classes  ?

• C25B 11/089 - Alloys
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/054 - Electrodes comprising electrocatalysts supported on a carrier
• C25B 11/061 - Metal or alloy
• C25B 11/065 - Carbon

Abstract

3-x3-x porous nanorod catalyst on the basis of a metal-organic framework and a non-precious alloy catalyst prepared thereby. The method for preparing a non-precious alloy catalyst according to the present invention can produce an alloy catalyst retaining excellent HER performance close to that of a commercial platinum catalyst by forming porous nanorods with a wide surface area having a combination of an alloy and an oxide.

IPC Classes  ?

• B01J 37/08 - Heat treatment
• B01J 37/16 - Reducing
• B01J 37/06 - Washing
• B01J 35/02 - Solids
• B01J 35/10 - Solids characterised by their surface properties or porosity
• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
• B01J 23/883 - Molybdenum and nickel
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water

Abstract

Provided is a polycarbonate copolymer including a repeating unit of the following Chemical Formula 1, where the polycarbonate copolymer can have improved heat resistance: Provided is a polycarbonate copolymer including a repeating unit of the following Chemical Formula 1, where the polycarbonate copolymer can have improved heat resistance: Provided is a polycarbonate copolymer including a repeating unit of the following Chemical Formula 1, where the polycarbonate copolymer can have improved heat resistance: wherein in Chemical Formula 1, R1, R2, n1 and n2 are as defined in the specification.

IPC Classes  ?

• C08G 64/12 - Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen containing nitrogen
• C08G 64/30 - General preparatory processes using carbonates

Abstract

The present invention relates to a brain tumor animal model that directly reflects the phenomenon in a human patient and a method of preparing the same, and more specifically, a brain tumor animal model that mutations are introduced into p53, Pten, and EGFR genes, a screening method of a therapeutic agent for a brain tumor using the animal model, and a preparing method thereof.

IPC Classes  ?

• A01K 67/027 - New or modified breeds of vertebrates

Abstract

A transistor includes a semiconductor layer on a substrate, a gate electrode overlapping the semiconductor layer, and a source electrode and a drain electrode electrically connected to the semiconductor layer. The semiconductor layer includes a second material doped to a first material. The first material includes a compound expressed as XYa of a Chemical Formula. X is one of Mo, W, Zr, or Re, Y is one of S, Se, or Te, and a is a natural number that is equal to or greater than 1. The second material includes at least one of W, Hf, Ta, Ti, Pt, Ni, Ga, or Zr. The second material includes an element that is different from the first material.

IPC Classes  ?

• H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , ,  or
• H01L 29/40 - Electrodes

Abstract

Provided are: a novel pyrrolidine derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing same and having the effects of inhibiting beta-amyloid and/or tau protein aggregation, and/or breaking down beta-amyloid and/or tau protein aggregates, and/or preventing and/or treating beta-amyloid and/or tau protein-associated diseases.

IPC Classes  ?

• A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 487/04 - Ortho-condensed systems
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 277/36 - Sulfur atoms
• C07D 233/96 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members

Abstract

The present invention is to provide a polycarbonate copolymer comprising a repeating unit represented by chemical formula 1 in the present specification, and may provide a polycarbonate copolymer improved, specifically in terms of heat resistance, by including the repeating unit having the specific structure of chemical formula 1.

IPC Classes  ?

• C08G 64/12 - Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen containing nitrogen
• C08G 64/16 - Aliphatic-aromatic or araliphatic polycarbonates
• C08L 69/00 - Compositions of polycarbonatesCompositions of derivatives of polycarbonates

Abstract

A tomographic imaging system includes a light source, a light irradiation unit that irradiates light to a transparent material composite thin film sample and a reference mirror and acquires an interference signal between light reflected and scattered from the sample and light reflected from the reference mirror, a light measuring unit that measures the interference signal acquired by the light irradiation unit, a light transmission unit that transmits the light output from the light source to the light irradiation unit and transmits the interference signal of the light transmitted from the light irradiation unit to the light measuring unit; and a signal processing apparatus that converts the interference signal of the sample, outputs the converted interference signal as a tomographic image, and monitors the interference signal acquired by the light irradiation unit to modulate intensity and a polarization state of the light input to the light irradiation unit.

IPC Classes  ?

• G01B 9/02 - Interferometers
• G01N 21/47 - Scattering, i.e. diffuse reflection
• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
• G01B 9/02001 - Interferometers characterised by controlling or generating intrinsic radiation properties

Abstract

A method for predicting a molecular structure includes: preparing a learning data set including first learning data including an eigenvector value and a quantum mechanics calculation value for a monoatomic and molecular structural model, a bulk structural model, a slab structural model, and a nanoparticle structural model of a material including a plurality of elements; learning an artificial neural network using the learning data set to obtain a potential value; and predicting a molecular structure of another material by using the potential value.

IPC Classes  ?

• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers

Abstract

The present invention relates to a novel compound having inhibitory activity against pendrin, and pharmaceutical uses thereof, and provides a compound represented by formula 1 below, an E- or Z-isomer thereof, an optical isomer thereof, a precursor thereof, a pharmaceutically acceptable salt thereof, a solvate thereof or a mixture of two or more isomers thereof, and a composition for preventing, relieving or treating respiratory diseases and a diuretic composition, each composition utilizing the inhibitory activity of the compound against pendrin.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 11/00 - Drugs for disorders of the respiratory system
• C07D 209/12 - Radicals substituted by oxygen atoms
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 7/10 - Antioedematous agentsDiuretics
• C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

A method of manufacturing microstructure array, a microstructure array, a micro-light-emitting diode, and a method for manufacturing the same, and a display device. The method of manufacturing microstructure array includes: preparing a red light-emitting perovskite precursor solution, a green light-emitting perovskite precursor solution, and a blue light-emitting perovskite precursor solution; coating the red light-emitting perovskite precursor solution, the green light-emitting perovskite precursor solution, and the blue light-emitting perovskite precursor solution, on a substrate having partitioned first, second, and third regions to form a red light-emitting perovskite precursor film, a green light-emitting perovskite precursor film, and a blue light-emitting perovskite precursor film, respectively; disposing a mold having a plurality of concave micropatterns on the red light-emitting perovskite precursor film, the green light-emitting perovskite precursor film, and the blue light-emitting perovskite precursor film, respectively; heat-treating the red light-emitting perovskite precursor film, the green light-emitting perovskite precursor film, and the blue light-emitting perovskite precursor film in a plurality of concave micropatterns to obtain each of red light-emitting perovskite nanocrystals, green light-emitting perovskite nanocrystals, and blue light-emitting perovskite nanocrystals, and removing the mold to form a microstructure array.

IPC Classes  ?

• H01L 51/56 - Processes or apparatus specially adapted for the manufacture or treatment of such devices or of parts thereof
• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
• H01L 51/50 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for light emission, e.g. organic light emitting diodes (OLED) or polymer light emitting devices (PLED)

Abstract

The present invention relates to: a method for preparing a reduction catalyst for water electrolysis, using protective coating; a reduction electrode for alkaline water electrolysis, comprising a reduction catalyst prepared thereby; and an alkaline water electrolysis system. The method for preparing a reduction catalyst for water electrolysis of the present invention applies a protective coating method and inhibits the growth of alloy particles in a later high-temperature heat treatment step, and, thus, can prepare and provide a catalyst with a high alloying degree. As a result, a non-precious metal alloy catalyst prepared according to the method of the present invention has excellent catalytic characteristics by exhibiting hydrogen evolution reaction (HER) performance similar to that of platinum, which is a precious metal catalyst.

IPC Classes  ?

• B01J 37/08 - Heat treatment
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 21/18 - Carbon
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/089 - Alloys
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded

Abstract

The present invention relates to: a method for preparing a reduction catalyst for water electrolysis, using protective coating; a reduction electrode for alkaline water electrolysis, comprising a reduction catalyst prepared thereby; and an alkaline water electrolysis system. The method for preparing a reduction catalyst for water electrolysis of the present invention applies a protective coating method and inhibits the growth of alloy particles in a later high-temperature heat treatment step, and, thus, can prepare and provide a catalyst with a high alloying degree. As a result, a non-precious metal alloy catalyst prepared according to the method of the present invention has excellent catalytic characteristics by exhibiting hydrogen evolution reaction (HER) performance similar to that of platinum, which is a precious metal catalyst.

IPC Classes  ?

• B01J 21/18 - Carbon
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/08 - Heat treatment
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 11/089 - Alloys

Abstract

Disclosed is a method of manufacturing a ternary catalyst for an oxygen reduction reaction. The method may include constructing a database including catalytic activity of oxygen reduction reaction (ORR) of PtFeCu nanoparticles using machine-learning-based neural network potential (NNP), determining thermodynamically stable PtFeCu nanoparticles through Monte Carlo calculation, and selecting a type of the PtFeCu nanoparticles by analyzing a structure of PtFeCu nanoparticles.

IPC Classes  ?

• G16C 20/70 - Machine learning, data mining or chemometrics
• G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
• B82Y 35/00 - Methods or apparatus for measurement or analysis of nanostructures
• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes

Abstract

A memory controlling device configured to connect to a memory module including a resistance switching memory cell array which is partitioned into a plurality of partitions including a first partition and a second partition is provided. A first controlling module accesses the memory module. A second controlling module determines whether there is a conflict for the first partition to which a read request targets when an incoming request is the read request, instructs the first controlling module to read target data of the read request from the memory module when a write to the second partition is in progress, and suspends the read request when a write to the first partition is in progress.

IPC Classes  ?

• G06F 12/08 - Addressing or allocationRelocation in hierarchically structured memory systems, e.g. virtual memory systems
• G11C 14/00 - Digital stores characterised by arrangements of cells having volatile and non-volatile storage properties for back-up when the power is down
• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
• G06F 12/0804 - Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches with main memory updating
• G06F 12/0895 - Caches characterised by their organisation or structure of parts of caches, e.g. directory or tag array
• G06F 13/16 - Handling requests for interconnection or transfer for access to memory bus

Abstract

Disclosed are a method and device for assisting renal disease diagnosis. According to an aspect of the present invention, provided is a method for assisting diagnosis of a subject renal disease by using a fundus image, the method comprising the steps of: obtaining a subject fundus image which is a captured image of the fundus of a subject; obtaining renal disease diagnosis assistance information of the subject in accordance with the subject fundus image, by means of a renal disease diagnosis assistance neural network model obtaining diagnosis assistance information to be used in diagnosing the subject renal disease in accordance with the fundus image, on the basis of the subject fundus image; and outputting the renal disease diagnosis assistance information of the subject, wherein the renal disease diagnosis assistance information comprises at least one from among: level information comprising a level selected from a plurality of levels indicating the risk of subject renal disease; score information which is numerical information for determining the risk score of the subject renal disease; and risk information indicating whether or not the subject belongs to a subject renal disease risk group.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/20 - Measuring urological functions
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
• G06N 3/08 - Learning methods
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

The present invention relates to a novel compound, and a composition for preventing or treating of respiratory disease comprising the novel compound, E- or Z-isomer thereof, optical isomer thereof, a mixture of two isomers thereof, precursor thereof, pharmaceutically acceptable salt thereof or solvate thereof as an active ingredient.

IPC Classes  ?

• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 11/06 - Antiasthmatics
• C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 263/42 - One oxygen atom attached in position 5
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 495/04 - Ortho-condensed systems
• C07D 413/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 207/337 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 333/24 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 307/54 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 277/30 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 333/60 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 209/20 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/421 - 1,3-Oxazoles, e.g. pemoline, trimethadione
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/415 - 1,2-Diazoles

Abstract

The present invention relates to a medicinal use of compounds having inhibitory activity against pendrin, and provides a compound represented by chemical formula 1 or 2, below, an E- or Z-isomer thereof, an optical isomer thereof, a precursor thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, or a mixture of two or more isomers thereof, and a composition for prevention, alleviation, or treatment of respiratory diseases, or a diuretic composition, each composition utilizing the inhibitory activity of the compound against pendrin. [chemical formula 1] [chemical formula 2]

IPC Classes  ?

• C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 11/00 - Drugs for disorders of the respiratory system
• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 495/04 - Ortho-condensed systems

Abstract

An antifouling coating composition including a copolymer including two or more moieties represented by Chemical Formula 1, and a linking group between the two or more moieties, a method of preparing the copolymer, and an antifouling film produced from the antifouling coating composition. In Chemical Formula 1, the definitions of Ar, A, B, C, D, and m are as described in the specification.

IPC Classes  ?

• C09D 5/16 - Anti-fouling paintsUnderwater paints
• C08G 65/00 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
• C09D 171/02 - Polyalkylene oxides
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides

Abstract

Disclosed are, inter alia, an electrode for oxygen evolving, a method of preparing the electrode, and an oxygen generating device including the electrode. The electrode for oxygen evolving includes a metal nanocluster including a core formed of metal atoms and an organic thiol-containing ligand bound to a surface of the core, and a metal support to which the metal nanocluster is fixed. Disclosed are, inter alia, an electrode for oxygen evolving, a method of preparing the electrode, and an oxygen generating device including the electrode. The electrode for oxygen evolving includes a metal nanocluster including a core formed of metal atoms and an organic thiol-containing ligand bound to a surface of the core, and a metal support to which the metal nanocluster is fixed. According to various exemplary embodiments of the present invention, e.g., by using the electrode, a non-precious metal/non-carbon catalyst may be used as a catalyst for oxygen evolving, which is a half reaction of alkaline water electrolysis, oxygen evolving activity and high stability may be substantially improved, a catalyst usage amount may be minimized by increasing dispersibility of a catalyst in an electrode, and an efficiency of an oxygen evolving device may be increased by increasing a surface area of an electrode and decreasing electrolyte resistance.

IPC Classes  ?

• C25B 11/04 - ElectrodesManufacture thereof not otherwise provided for characterised by the material
• C25B 11/03 - ElectrodesManufacture thereof not otherwise provided for characterised by shape or form perforated or foraminous
• C25B 9/06 - Cells comprising dimensionally-stable non-movable electrodes; Assemblies of constructional parts thereof
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water

Abstract

Provided are: a novel pyrrolidine derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing same and having the effects of inhibiting beta-amyloid and/or tau protein aggregation, and/or breaking down beta-amyloid and/or tau protein aggregates, and/or preventing and/or treating beta-amyloid and/or tau protein-associated diseases.

IPC Classes  ?

• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• C07D 277/36 - Sulfur atoms
• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 471/04 - Ortho-condensed systems
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Provided is a use of the prophylaxis, amelioration or therapy of intractable epilepsy, for example, Focal Cortical Dysplasia (FCD).

IPC Classes  ?

• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A01K 67/027 - New or modified breeds of vertebrates
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
• A61P 25/08 - AntiepilepticsAnticonvulsants

Abstract

Disclosed are a method of manufacturing a microstructure array that includes preparing a mold having a concave micro pattern array in which a plurality of concave micro patterns are arranged, preparing a perovskite precursor solution including a perovskite precursor and a hydrophilic polymer, coating the perovskite precursor solution on a substrate, disposing the mold on the perovskite precursor solution to confine the perovskite precursor solution in the plurality of concave micro patterns, obtaining a composite of perovskite nanocrystals and the hydrophilic polymer from the perovskite precursor solution in the plurality of concave micro patterns, and, and removing the mold to form a microstructure array in which a plurality of microstructures including a composite of the perovskite nanocrystals and the hydrophilic polymer are arranged, a microstructure array, a micro light emitting diode including the same, and a manufacturing method thereof, and a display device.

IPC Classes  ?

• H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
• H01L 25/04 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices all the devices being of a type provided for in a single subclass of subclasses , , , , or , e.g. assemblies of rectifier diodes the devices not having separate containers
• H01L 51/50 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for light emission, e.g. organic light emitting diodes (OLED) or polymer light emitting devices (PLED)

Abstract

A resistive switching memory device according to an exemplary embodiment includes: a first electrode; a second electrode formed to be separated from the first electrode; and an insulating layer formed near the first electrode and the second electrode, and changed to one of a high resistance state and a low resistance state when a conductive filament is controlled by a change of external humidity or a voltage applied through the first electrode or the second electrode.

IPC Classes  ?

• H01L 45/00 - Solid state devices specially adapted for rectifying, amplifying, oscillating, or switching without a potential-jump barrier or surface barrier, e.g. dielectric triodes; Ovshinsky-effect devices; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof
• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or

Abstract

The present invention provides a method for detection of a mutation in a nucleotide sequence, the method comprising the steps of: obtaining a plurality of target genes for one subject sample by using a gene panel including probes for the plurality of target genes; collecting multiple replicates of nucleotide sequences including nucleotide sequences being identical or non-identical with each of the plurality of target genes by sequencing each of the plurality of target genes in multiple rounds through next generation sequencing (NGS); matching the multiple replicates of nucleotide sequences with reference nucleotide sequences; determining nucleotide sequences unmatched with the reference nucleotide sequences for the plurality of target genes among the multiple replicates of nucleotide sequences; and determining candidates of nucleotide sequence mutations for the plurality of target genes in the subject sample, based on a probability of mutation for a discordant gene locus with the unmatched nucleotide sequences, the probability of mutation being calculated by a computational method according to statistical analysis of unmatched nucleotide sequences.

IPC Classes  ?

• C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• G06F 17/18 - Complex mathematical operations for evaluating statistical data

Abstract

The present invention relates to a biomarker of epilepsy, a composition for diagnosing epilepsy, an epilepsy-induced animal, and a composition for preventing or treating epilepsy, and specifically, relates to a composition for diagnosing epilepsy comprising a BRAF mutant protein and a nucleic acid molecule, and an agent capable of detecting the protein or nucleic acid molecule, an epilepsy-induced animal transformed with the BRAF mutant nucleic acid molecule, and a composition for prevention or treatment of epilepsy comprising a BRAF mutant protein activity inhibitor.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A01K 67/027 - New or modified breeds of vertebrates
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

Abstract

The present invention relates to a novel compound, and a composition for the prevention or treatment of respiratory diseases comprising, as an active ingredient, the novel compound, an E-isomer or Z-isomer thereof, an optical isomer thereof, a mixture of two isomers thereof, a precursor thereof, a pharmaceutically acceptable salt thereof, or a solvate thereof.

IPC Classes  ?

• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61P 11/00 - Drugs for disorders of the respiratory system
• C07D 263/42 - One oxygen atom attached in position 5
• C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

A memory controlling device configured to connect to a memory module including a resistance switching memory cell array which is partitioned into a plurality of partitions including a first partition and a second partition is provided. A first controlling module accesses the memory module. A second controlling module determines whether there is a conflict for the first partition to which a read request targets when an incoming request is the read request, instructs the first controlling module to read target data of the read request from the memory module when a write to the second partition is in progress, and suspends the read request when a write to the first partition is in progress.

IPC Classes  ?

• G06F 12/08 - Addressing or allocationRelocation in hierarchically structured memory systems, e.g. virtual memory systems
• G11C 14/00 - Digital stores characterised by arrangements of cells having volatile and non-volatile storage properties for back-up when the power is down
• G06F 13/16 - Handling requests for interconnection or transfer for access to memory bus
• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
• G06F 12/0804 - Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches with main memory updating
• G06F 12/0895 - Caches characterised by their organisation or structure of parts of caches, e.g. directory or tag array

Abstract

The present invention relates to an antimicrobial polymer coating composition comprising: a urethane acrylate-based oligomer or polymer having a molar ratio of a urethane functional group to a (meth)acrylate-based functional group of 1 to 10; a photosensitizer; and a photoinitiator; an antimicrobial polymer film comprising a cured product of the antimicrobial polymer coating composition; and an antimicrobial polymer film comprising a predetermined urethane acrylate-based polymer resin; and a photosensitizer dispersed in the polymer resin, wherein the polymer film has oxygen permeability of 5 to 100 cc/m2 day.

IPC Classes  ?

• A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• A01N 25/10 - Macromolecular compounds

Abstract

A memory system including a memory subsystem and a memory controller is provided. The memory subsystem includes a plurality of first memory modules implemented by a phase-change memory and a second memory module implemented by a memory whose write speed is faster than that of the phase-change memory. The memory controller generates a non-blocking code from a plurality of sub-data into which original data are divided, writes the non-blocking code to the second memory module, writes the plurality of sub-data to the plurality of first memory modules, respectively, and reconstructs the original data from some sub-data of the plurality of sub-data which are read from some of the plurality of first memory modules and the non-blocking code read from the second memory under a predetermined condition at a read request.

IPC Classes  ?

• G06F 12/02 - Addressing or allocationRelocation
• G06F 3/06 - Digital input from, or digital output to, record carriers
• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead

Abstract

A memory system including a memory subsystem and a memory controller is provided. The memory subsystem includes a plurality of first memory modules implemented by a phase-change memory and a second memory module implemented by a memory whose write speed is faster than that of the phase-change memory. The memory controller generates a non-blocking code from a plurality of sub-data into which original data are divided, writes the non-blocking code to the second memory module, writes the plurality of sub-data to the plurality of first memory modules, respectively, and reconstructs the original data from some sub-data of the plurality of sub-data which are read from some of the plurality of first memory modules and the non-blocking code read from the second memory under a predetermined condition at a read request.

IPC Classes  ?

• G06F 12/02 - Addressing or allocationRelocation
• G06F 3/06 - Digital input from, or digital output to, record carriers
• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead

Abstract

A memory controlling device configured to connect to a first memory module including a resistance switching memory cell array which is partitioned into a plurality of partitions and a second memory module used for a cache is provided. A cache controller splits an address of a read request into at least a first cache index and a first tag, and determines whether the read request is a cache hit or a cache miss by referring to a lookup logic based on the first cache index and the first tag. The cache controller instructs the memory controller to read target data of the read request from the first memory module when the read request targets to the second partition in a case where the read request is the cache miss and a write to the first partition is in progress.

IPC Classes  ?

• G06F 12/08 - Addressing or allocationRelocation in hierarchically structured memory systems, e.g. virtual memory systems
• G11C 14/00 - Digital stores characterised by arrangements of cells having volatile and non-volatile storage properties for back-up when the power is down
• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
• G06F 13/16 - Handling requests for interconnection or transfer for access to memory bus
• G06F 12/0804 - Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches with main memory updating
• G06F 12/0895 - Caches characterised by their organisation or structure of parts of caches, e.g. directory or tag array

Abstract

The present invention relates to a brain tumor animal model that directly reflects the phenomenon in a human patient and a method of preparing the same, and more specifically, a brain tumor animal model that mutations are introduced into p53, Pten, and EGFR genes, a screening method of a therapeutic agent for a brain tumor using the animal model, and a preparing method thereof.

IPC Classes  ?

• A01K 67/027 - New or modified breeds of vertebrates
• A61K 49/00 - Preparations for testing in vivo

Abstract

A magnetoresistive memory module used as a main memory of a computing device is provided. A plurality of memory chips are mounted on a printed circuit board, and a memory controller performs data scrubbing. Each memory chip includes a plurality of magnetoresistive memory cells. Each magnetoresistive memory cell includes a magnetoresistive element and an access transistor that transfers a current to the magnetoresistive element, and has a size of a cell area that is substantially similar to a size of a DRAM cell area.

IPC Classes  ?

• G06F 3/06 - Digital input from, or digital output to, record carriers
• H01L 27/22 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate using similar magnetic field effects
• H01F 10/32 - Spin-exchange-coupled multilayers, e.g. nanostructured superlattices
• H01L 43/02 - Devices using galvano-magnetic or similar magnetic effects; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof - Details
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• G06F 11/10 - Adding special bits or symbols to the coded information, e.g. parity check, casting out nines or elevens
• G06N 20/00 - Machine learning
• H05K 1/18 - Printed circuits structurally associated with non-printed electric components
• H01L 43/08 - Magnetic-field-controlled resistors
• G11C 11/56 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using storage elements with more than two stable states represented by steps, e.g. of voltage, current, phase, frequency
• G06F 13/16 - Handling requests for interconnection or transfer for access to memory bus

Abstract

Sensing voltage based on supply voltage applied to an MRAM bit cell in a write operation can be used to detect completion of magnetic tunnel junction (MTJ) switching in an MRAM bit cell to terminate the write operation to reduce power and write times. In exemplary aspects disclosed herein, reference and write operation voltages sensed from the MRAM bit cell in response to the write operation are compared to each other to detect completion of MTJ switching of voltage based on the supply voltage applied to the MRAM bit cell regardless of whether the write operation is logic '0' or logic T write operation. This provides a higher sensing margin, because the change in MTJ resistance after MTJ switching completion is larger at the supply voltage rail.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
• G11C 27/02 - Sample-and-hold arrangements

Abstract

Offset-cancellation sensing circuit (OCSC)-based Non-volatile (NV) memory circuits are disclosed. An OCSC-based NV memory circuit includes a latch circuit configured to latch a memory state from an input signal. The OCSC-based NV memory circuit also includes a sensing circuit that includes NV memory devices configured to store the latched memory state in the latch circuit for restoring the memory state in the latch circuit when recovering from a reduced power level in an idle mode. To avoid the need to increase transistor size in the sensing circuit to mitigate restoration degradation, the sensing circuit is also configured to cancel an offset voltage of a differential amplifier in the sensing circuit. In other exemplary aspects, the NV memory devices are included in the sensing circuit and coupled to the differential transistors as NMOS transistors in the differential amplifier, eliminating contribution of offset voltage from other differential PMOS transistors not included.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect

Abstract

A memory controlling device of a computing device including a CPU, a memory, and a flash-based storage device is provided. The memory controlling device includes an address manager and an interface. The address manager aggregates a memory space of the memory and a storage space of the storage device into an expanded memory space, and handles a memory request for the expanded memory space from the CPU by using the memory space of the memory as a cache for the storage space of the storage device. The interface is used to access the memory and the storage device.

IPC Classes  ?

• G06F 12/0804 - Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches with main memory updating
• G06F 12/10 - Address translation

Abstract

Aspects disclosed in the detailed description include offset-canceling (OC) write operation sensing circuits for sensing switching in a magneto-resistive random access memory (MRAM) bit cell in an MRAM for a write operation. The OC write operation sensing circuit is configured to sense when MTJ switching occurs in MRAM bit cell. In an example, the OC write operation sensing circuit includes a voltage sensing circuit and a sense amplifier. The voltage sensing circuit employs a capacitive-coupling effect so that the output voltage drops in response to MTJ switching for both logic ‘0’ and logic ‘1’ write operations. The sense amplifier has a single input and a single output node with an output voltage indicating when MTJ switching has occurred in the MRAM bit cell. A single input transistor and pull-up transistor are provided in the sense amplifier in one example to provide an offset-canceling effect.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• H01L 43/08 - Magnetic-field-controlled resistors
• G11C 7/06 - Sense amplifiersAssociated circuits

Abstract

The present invention relates to a DNA aptamer specifically binding to a hepatocellular carcinoma-related Glypican-3 (GPC3) protein, treatment of cancers related to the Glypican-3 protein using the same, a composition for inhibiting a cancer and a composition for diagnosing a cancer comprising the same as an active ingredient.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention relates to an antimicrobial polymer coating composition comprising a urethane acrylate-based oligomer or polymer with a molar ratio of urethane functional groups to (meth)acrylate-based functional groups of 1 to 10; a photosensitizer; and a photoinitiator, and to an antimicrobial polymer film comprising a cured product of the antimicrobial polymer coating composition; a predetermined urethane acrylate-based polymer resin; and a photosensitizer dispersed in the polymer resin, wherein the antimicrobial polymer film has an oxygen permeability of 5 to 100 cc/m2 day.

IPC Classes  ?

• C09D 175/16 - Polyurethanes having carbon-to-carbon unsaturated bonds having terminal carbon-to-carbon unsaturated bonds
• C09D 5/14 - Paints containing biocides, e.g. fungicides, insecticides or pesticides
• C09D 4/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond
• C09D 7/63 - Additives non-macromolecular organic
• C08J 7/04 - Coating
• C08J 5/18 - Manufacture of films or sheets

Abstract

An under-sampling apparatus for MR image reconstruction by using machine learning and a method thereof, an MR image reconstruction device by using machine learning and a method thereof, and a recoding medium thereof are disclosed. The disclosed under-smapling apparatus includes: a setting portion that sets a region corresponding to a center of the k-space image as a first region and remaining regions as a second region; and an under-sampling portion that full-samples the first region and under-samples the second region, wherein in the under-sampling performed in the second region, lines are selected at regular intervals and then only the selected line is full-sampled. According to the under-sampling apparatus, a high-resolution MR image can be acquired while reducing imaing time.

IPC Classes  ?

• G01R 33/48 - NMR imaging systems
• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
• G06T 7/00 - Image analysis
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques

Abstract

Sensing voltage based on a supplied to magneto-resistive random access memory (MRAM) bit cells in an MRAM for tracking write operations. Sensing voltage based on supply voltage applied to an MRAM bit cell in a write operation can be used to detect completion of magnetic tunnel junction (MTJ) switching in an MRAM bit cell to terminate the write operation to reduce power and write times. In exemplary aspects provided herein, reference and write operation voltages sensed from the MRAM bit cell in response to the write operation are compared to each other to detect completion of MTJ switching of voltage based on the supply voltage applied to the MRAM bit cell regardless of whether the write operation is logic ‘0’ or logic ‘1’ write operation. This provides a higher sensing margin, because the change in MTJ resistance after MTJ switching completion is larger at the supply voltage rail.

IPC Classes  ?

• G11C 11/00 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• H01L 27/22 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate using similar magnetic field effects
• H01L 43/02 - Devices using galvano-magnetic or similar magnetic effects; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof - Details
• H01L 43/08 - Magnetic-field-controlled resistors

Abstract

The present invention provides methods and devices for detection of nucleotide sequence mutations. Target genes are obtained by hybridization probes, and a library construction is performed with the target genes. Each target gene is sequenced through next generation sequencing (NGS) to produce multiple replicates, some of which contain background error. The multiple replicates are matched against reference nucleotide sequences, and mutation candidates are determined based on probability of mutation as well as probability of background error for the discordant gene locus of the mismatched nucleotide sequences, calculated by a computational method according to statistical analysis of mismatched nucleotide sequences. The nucleotide sequence mutation is a somatic mutation with low-variant allele frequency of 1 % or less.

IPC Classes  ?

• C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

A method and an apparatus for authenticating user using biometric information. The apparatus authenticates the user by performing: generating a first feature vector from first biometric information of the user obtained by the biometric sensor and multiplying the first feature vector by a plurality of pseudo-random number (PRN) matrices, respectively; generating a query template based on an index of an element having a maximum value among elements of a result vector of the multiplication between the first feature vector and the plurality of PRN matrices; and performing authentication for the user by comparing the query template with a pre-stored reference template of a subscribed user.

IPC Classes  ?

• G06F 21/00 - Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity
• H04L 29/06 - Communication control; Communication processing characterised by a protocol
• G06F 21/32 - User authentication using biometric data, e.g. fingerprints, iris scans or voiceprints
• H04L 9/08 - Key distribution
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system

Abstract

A resistance switching memory-based accelerator configured to be connected to a host including a CPU and a system memory is provided. A resistance switching memory module includes a memory cell array including a plurality of resistance switching memory cells, and stores a kernel offloaded from the host. An accelerator core includes a plurality of processing elements, and the kernel is executed by a target processing element among the plurality of processing elements. An MCU manages a memory request generated in accordance with execution of the kernel by the target processing element. A memory controller is connected to the resistance switching memory module, and allows data according to the memory request to move between the resistance switching memory module and the target processing element, in accordance with the memory request transferred from the MCU. A network integrates the accelerator core, the plurality of processing elements, and the memory controller.

IPC Classes  ?

• G06F 12/00 - Accessing, addressing or allocating within memory systems or architectures
• G06F 3/06 - Digital input from, or digital output to, record carriers
• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
• G06F 13/16 - Handling requests for interconnection or transfer for access to memory bus

Abstract

A flash-based accelerator configured to be connected to a host including a CPU and a system memory is provided. A plurality of processors execute a plurality of kernels offloaded from the host. A memory system includes a first memory that is used to map a data section of each kernel to the flash memory. A supervisor processor maps a region of the first memory pointed by a data section of a first kernel to a region of the flash memory to allow first data to move between the region of the first memory and the region of the flash memory, based on a first message which is transferred in accordance with execution of the first kernel by a first processor among the plurality of processors. A network integrates the flash backbone, the memory system, the plurality of processors, and the supervisor processor.

IPC Classes  ?

• G06F 12/02 - Addressing or allocationRelocation
• G06F 3/06 - Digital input from, or digital output to, record carriers
• G06F 13/16 - Handling requests for interconnection or transfer for access to memory bus
• G06F 12/1009 - Address translation using page tables, e.g. page table structures

Abstract

A computing device includes a CPU, a CPU memory for CPU, a non-volatile memory, a coprocessor using the non-volatile memory, a coprocessor memory for storing data to be processed by the coprocessor or data processed by the coprocessor, and a recording medium. The recording medium includes a controller driver for the non-volatile memory and a library that are executed by the CPU. The controller driver maps the coprocessor memory to a system memory block of the CPU memory. The library moves data between the coprocessor and the non-volatile memory via the system memory block mapped to the coprocessor memory.

IPC Classes  ?

• G06F 12/02 - Addressing or allocationRelocation
• G06F 12/06 - Addressing a physical block of locations, e.g. base addressing, module addressing, address space extension, memory dedication
• G06F 13/40 - Bus structure

Abstract

A magnetoresistive memory module used as a main memory of a computing device is provided. A plurality of memory chips is mounted on a printed circuit board and a memory controller performs data scrubbing. Each memory chip comprises a plurality of magnetoresistive memory cells. Each magnetoresistive memory cell comprises a magnetoresistive element and an access transistor for delivering a current to the magnetoresistive element, and has a cell region size substantially similar to a DRAM cell region size.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• G11C 11/56 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using storage elements with more than two stable states represented by steps, e.g. of voltage, current, phase, frequency
• H01L 43/08 - Magnetic-field-controlled resistors
• G06F 11/10 - Adding special bits or symbols to the coded information, e.g. parity check, casting out nines or elevens
• G06F 13/16 - Handling requests for interconnection or transfer for access to memory bus

Abstract

In a coprocessor performing data processing by supplementing functions of a CPU of a host or independently of the CPU, a processing element corresponding to a core of the coprocessor executes a kernel transferred from the host, and a server manages a memory request generated according to an execution of the kernel by the processing element. A memory controller connected to the resistance switching memory module moves data corresponding to the memory request between the resistance switching memory module and the processing element in accordance with the memory request transferred from the server. A network integrates the processing element, the server, and the memory controller.

IPC Classes  ?

• G06F 12/00 - Accessing, addressing or allocating within memory systems or architectures
• G06F 3/06 - Digital input from, or digital output to, record carriers
• G06F 13/16 - Handling requests for interconnection or transfer for access to memory bus
• G06F 12/0804 - Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches with main memory updating
• G06F 12/0897 - Caches characterised by their organisation or structure with two or more cache hierarchy levels

Abstract

In a parallel processing unit comprising a multi-processor, the multi-processor comprises: a level-1 data (L1D) cache; and a memory unit having a shared memory to which a plurality of cache lines are allocated. A thread group scheduler isolates a second thread group from a first thread group that is in an active state, if it satisfies a pre-determined first condition, by altering cache accesses of the second thread group to a shared memory.

IPC Classes  ?

• G06F 9/46 - Multiprogramming arrangements
• G06F 12/084 - Multiuser, multiprocessor or multiprocessing cache systems with a shared cache

Abstract

The present invention relates to a nanoperforator comprising a lipid-bilayer nanodisc and a membrane-structured protein surrounding the nanodisc and to a pharmaceutical composition comprising the nanoperforator as an active ingredient for preventing or treating viral infectious diseases. The use of the lipid-bilayer nanoperforator provided in the present invention can lead to the safe prevention or treatment of a disease caused by viral infection regardless of whether the virus is a variant or not, and thus the present invention can be widely used for the safe and effective treatment of viral infectious diseases.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 39/12 - Viral antigens
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/566 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent

Abstract

Metal-oxide semiconductor (MOS) transistor offset-cancelling (OC), zero-sensing (ZS) dead zone, current-latched sense amplifiers (SAs) (CLSAs) (OCZS-SAs) for sensing differential voltages are provided. An OCZS-SA is configured to amplify received differential data and reference input voltages with a smaller sense amplifier offset voltage to provide larger sense margin between different storage states of memory bitcell(s). The OCZS-SA is configured to cancel out offset voltages of input and complement input transistors, and keep the input and complement input transistors in their activated state during sensing phases so that sensing is not performed in their “dead zones” when their gate-to-source voltage (Vgs) is below their respective threshold voltages. In other aspects, sense amplifier capacitors are configured to directly store the data and reference input voltages at gates of the input and complement input transistors during voltage capture phases to avoid additional layout area that would otherwise be consumed with additional sensing capacitor circuits.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect

Abstract

The present disclosure relates to a substrate unit of a nanostructure assembly type, an optical image apparatus including the same, and a controlling method thereof, and the substrate unit of the nanostructure assembly type according to an exemplary embodiment includes: a lower substrate; an upper substrate separated from the lower substrate, an observation object being able to be positioned at the upper substrate; and at least one metal nanostructure positioned on the lower substrate, wherein the at least one metal nanostructure is capable of being assembled on the lower substrate or separated from the lower substrate.

IPC Classes  ?

• H01L 21/68 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for positioning, orientation or alignment
• G02B 5/00 - Optical elements other than lenses
• G01Q 60/22 - Probes, their manufacture or their related instrumentation, e.g. holders
• G02B 3/00 - Simple or compound lenses
• C08K 3/08 - Metals
• G02B 6/122 - Basic optical elements, e.g. light-guiding paths
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

In a memory controller, a request handler processes a write request which is issued from a CPU and requests data write to a memory device using a phase change memory, and a request queue stores the write request. A scheduler returns a completion on the write request to the CPU when a predetermined write time has elapsed. The predetermined write time is shorter than a write latency time that is taken to complete the data write to a memory cell of the memory device in response to the write request.

IPC Classes  ?

• G06F 12/00 - Accessing, addressing or allocating within memory systems or architectures
• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

A flash controller of a flash-based storage device comprises a plurality of flash conversion layers respectively corresponding to a plurality of partition entities. Each partition entity comprises a flash memory chip, and each flash conversion layer maps a logical address obtained from a host to a corresponding physical address of a partition entity. The flash controller allocates the plurality of partition entities to a plurality of name spaces according to a command from the host.

IPC Classes  ?

• G06F 12/02 - Addressing or allocationRelocation
• G06F 12/06 - Addressing a physical block of locations, e.g. base addressing, module addressing, address space extension, memory dedication
• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

In a flash-based accelerator, a flash-based non-volatile memory stores data in pages, and a buffer subsystem stores data in words or bytes. An accelerator controller manages data movement between the flash-based non-volatile memory and the buffer subsystem. A plurality of processors processes data stored in the buffer subsystem. A network integrates the flash-based non-volatile memory, the buffer subsystem, the accelerator controller, and the plurality of processors.

IPC Classes  ?

• G06F 12/00 - Accessing, addressing or allocating within memory systems or architectures
• G06F 3/06 - Digital input from, or digital output to, record carriers
• G06F 13/16 - Handling requests for interconnection or transfer for access to memory bus
• G06F 12/02 - Addressing or allocationRelocation
• G06F 12/1009 - Address translation using page tables, e.g. page table structures

Abstract

A computing device includes a CPU, a CPU memory for CPU, a non-volatile memory, a coprocessor using the non-volatile memory, a coprocessor memory for storing data to be processed by the coprocessor or data processed by the coprocessor, and a recording medium. The recording medium includes a controller driver for the non-volatile memory and a library that are executed by the CPU. The controller driver maps the coprocessor memory to a system memory block of the CPU memory. The library moves data between the coprocessor and the non-volatile memory via the system memory block mapped to the coprocessor memory.

IPC Classes  ?

• G06F 12/02 - Addressing or allocationRelocation
• G06F 13/40 - Bus structure

Abstract

The present invention relates to prevention, improvement or treatment of intractable epilepsy, for example focal cortical dysplasia (FCD).

IPC Classes  ?

• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A01K 67/027 - New or modified breeds of vertebrates

Abstract

A method of preventing and/or treating a cancer, the method including co-administering a dual inhibitor of c-Met (hereinafter, ‘c-Met inhibitor’) and an IGF-1R inhibitor to a subject in need thereof and a use of IGF-1R as a marker for resistance to a c-Met inhibitor.

IPC Classes  ?

• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/74 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving hormones
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to a method for predicting the risk of colon cancer onset by identifying certain single nucleotide polymorphism (SNP) bases having a significant correlation with the risk of colon cancer onset, a composition including a polynucleotide, a polypeptide, an antibody or cDNA which can identify the SNP for predicting the risk of colon cancer onset, and a microarray and a kit including the composition.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

According to example embodiments, a metallic glass includes aluminum (Al), a first element group, and a second element group. The first element group includes at least one of a transition metal and a rare earth element. The second element group includes at least one of an alkaline metal, an alkaline-earth metal, a semi-metal, and a non-metal. The second element group and aluminum have an electronegativity difference of greater than or equal to about 0.25. The second element group is included less than or equal to about 3 at % of the metallic glass, based on the total amount of the aluminum (Al), the first element group, and the second element group. A conductive paste and/or an electrode of an electronic device may be formed using the metallic glass.

IPC Classes  ?

• H01B 1/00 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors
• H01B 1/02 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of metals or alloys

Abstract

A catalyst for reforming hydrocarbons may include a nickel nanoparticle having a controlled crystal facet, the controlled crystal facet being a surface of the nickel nanoparticle and including a {100} face, a {111} face, or a combination thereof. The present disclosure also relates to a production method thereof and a method of reforming hydrocarbons using the same.

IPC Classes  ?

• C01B 3/24 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of gaseous or liquid organic compounds of hydrocarbons
• B01J 23/755 - Nickel
• C01B 3/40 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using catalysts characterised by the catalyst
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 37/02 - Impregnation, coating or precipitation
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

2, satisfy Inequation 1: 1

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
• B82Y 40/00 - Manufacture or treatment of nanostructures
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

The present invention relates to a DNA aptamer specifically binding to integrin αvβ3, and a composition for diagnosing cancer or metastasis of cancer including the aptamer as an active ingredient. Also, the present invention relates to a composition for imaging neoplastic diseases including the aptamer, and a contrast medium including same.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• A61K 49/04 - X-ray contrast preparations