Abstract

An active disturbance rejection control method for a cable-driven continuum robot under actuator saturation constraints, comprising: first, establishing dynamics models of a cable-driven continuum robot, deriving a segmented dynamics model of the cable-driven continuum robot on the basis of a rotational symmetry theory of the cable-driven continuum robot, and on the basis of the dynamics model of any segment in the segmented dynamics model, obtaining the dynamics model of the cable-driven continuum robot considering actuator saturation constraints; then, using a control input quantity and a system output quantity that are subjected to saturation constraints as two input quantities of an extended state observer to design the extended state observer, and obtaining a state feedback control law on the basis of a first output quantity and a second output quantity of the extended state observer and a system reference input signal; and further obtaining a system control law on the basis of the state feedback control law, a third output quantity of the extended state observer, and an actual control input gain. According to the active disturbance rejection control method, the problem of limited driving cable tension in a cable-driven continuum robot system can be transformed into the problem of actuator saturation, and an actuator saturation constraint problem can be taken into account in controller design, so that the output of an actuator can be limited to a safe range to avoid damage to the system caused by excessive output of the actuator; additionally, in the controller design process, the system control input gain is not estimated, but the actual control input gain of the system is used, thereby not only reducing adjustable parameters of the controller, but also further improving the disturbance rejection performance, the tracking performance and the robustness of the system.

IPC Classes  ?

• B25J 9/16 - Programme controls

Abstract

A test device and test method for visually monitoring a tunnel seepage field. The test device comprises a bearing platform (1), support columns (2), a transparent test box (3), a tunnel model (4), a pressure pump, a water drawing pump, a laser transmitter, a PIV camera (5) and a computer. According to the device, PIV technology is used in a test, and the PIV camera (5) is used for capturing an image of motion of tracer particles in the transparent test box (3) irradiated by laser light, so that a seepage field flow velocity vector diagram can be formed, and a tunnel seepage field can be visually monitored in real time. Compared with tunnel seepage field data obtained by means of sensor data in the prior art, the seepage field flow velocity vector diagram obtained in the test device is not affected by the precision of sensors, so that the obtained tunnel seepage field flow velocity vector diagram is more accurate and suitable for research of tunnel seepage field rules.

IPC Classes  ?

• G01N 15/08 - Investigating permeability, pore volume, or surface area of porous materials

Abstract

Preparation and use of a metalloproteinase-activated CAR-T structure. The present invention specifically relates to a conditionally activated chimeric antigen receptor comprising a TSAR regulatory element, an engineered immune cell, a preparation method therefor and a use thereof. By utilizing the characteristic of high expression of matrix metalloproteinase in a tumor microenvironment, an engineered immune cell product based on conditional activation can achieve immunotherapy which does not easily go off-target and has lower toxic side effects and higher safety.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• A61K 35/14 - Blood; Artificial blood

Abstract

An intermediate module molecule for activating a chimeric antigen receptor effector cell and the use thereof, belonging to the field of biomedicines. The present invention emphasizes researching and developing the intermediate module molecule which can regulate the activity of a chimeric antigen receptor T cell and regulate the interaction between the chimeric antigen receptor T cell and a target cell. The module molecule comprises: (a) a targeting polypeptide, which is a tumor target-binding polypeptide; (b) an exogenous tag molecule, capable of binding to the chimeric antigen receptor on the effector cell, and (c) a linker, linking the targeting polypeptide to the exogenous tag molecule. The effector cell is selected from a dendritic cell, a killer dendritic cell, a mast cell, a natural killer cell, a B lymphocyte, a T lymphocyte, a macrophage and precursor cells thereof.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents

Abstract

Provided is a multi-tow carbon fiber spreading and pre-impregnation system, which is used to solve the technical problems of large thickness, high porosity and the like of a prepreg tape product caused by low spread ratio and insufficient pre-impregnation in the production process of existing thermoplastic prepreg tapes. The system includes a filament release module, a filament doubling module, an airflow spreading module, a process deviation correction module, a traction module, a slurry impregnation module, an infrared melting module, a hot-pressing shaping module, a floating roller module, a cutting module, a leftover collecting module, a winding deviation correction module and a winding module which are sequentially arranged along a feeding direction. The filament release module includes at least two filament release assemblies, and carbon fibers are placed on the filament release assemblies.

IPC Classes  ?

• B29B 15/12 - Coating or impregnating of reinforcements of indefinite length
• B29B 15/14 - Coating or impregnating of reinforcements of indefinite length of filaments or wires

Abstract

A process involves adding charged fibers with surface-cured “temperature-sensitive gel” during the preparation of concrete; preparing charged fibers with surface-cured “temperature-sensitive gel” by spraying, which envelops the charged fibers with a layer of “temperature-sensitive gel”; then solidifying the temperature-sensitive gel layer on the surface of the charged fibers by adjusting the environmental temperature. Utilizing the physical state of the temperature-sensitive gel at different temperatures, the “temperature-sensitive gel” wraps around the charged fibers to form an insulating layer. This prevents the scattering of the charged fibers due to charge repulsion during their introduction into the concrete preparation process, ensuring they are evenly distributed.

IPC Classes  ?

• C04B 20/10 - Coating or impregnating
• B05B 12/02 - Arrangements for controlling delivery; Arrangements for controlling the spray area for controlling time, or sequence, of delivery
• B28C 5/40 - Mixing specially adapted for preparing mixtures containing fibres
• C04B 14/04 - Silica-rich materials; Silicates
• C04B 14/06 - Quartz; Sand
• C04B 22/06 - Oxides; Hydroxides
• C04B 28/08 - Slag cements
• C04B 40/00 - Processes, in general, for influencing or modifying the properties of mortars, concrete or artificial stone compositions, e.g. their setting or hardening ability
• D06M 15/03 - Polysaccharides or derivatives thereof

Abstract

The present invention relates to the technical field of sodium-ion batteries, and in particular relates to an aqueous binder and the use thereof in a hard carbon negative electrode of a sodium-ion battery. The aqueous binder comprises a first component and a second component, wherein the first component is one or more of a styrene derivative polymer containing sodium ions or a pyran derivative polymer containing sodium ions, and the second component is a conductive polymer containing an ether bond. By controlling the addition amounts of the first component and the second component, the aqueous binder containing a large number of polar hydrophilic groups is obtained, and is suitable for a hard carbon negative electrode of a sodium-ion battery. The aqueous binder of the present invention is simple and convenient to prepare, has economical raw materials, and is green and environmentally friendly because of using deionized water as a solvent, such that a sodium-ion battery prepared from a hard carbon negative electrode using the aqueous binder has relatively high first-cycle coulombic efficiency, cycling stability and rate capability, and has relatively good commercial application prospects.

IPC Classes  ?

• C09J 125/18 - Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen

Abstract

The disclosure relates to the field of underground salt cavern energy storage, and discloses a coupling numerical simulation method for site selection of an underground salt cavern hydrogen storage, which specifically comprises the following. Geological data of an area where the salt cavern hydrogen storage is to be established is obtained. A three-dimensional model is established and grid meshing is performed. An initial coupling field is established and balanced based on the geological model, and then excavation simulation of the salt cavern hydrogen storage is performed. A geological model after excavation and related parameter values thereof are imported into TOUGH2MP software, a stress model in FLAC3D software is coupled with hydraulic and thermal models in the TOUGH2MP software to simulate a stress, hydraulic, and thermal coupling behavior process of rock layers around the salt cavern hydrogen storage in the area, and a coupled simulation result is obtained.

IPC Classes  ?

• G06F 30/23 - Design optimisation, verification or simulation using finite element methods [FEM] or finite difference methods [FDM]
• E21B 41/00 - Equipment or details not covered by groups
• G06F 111/10 - Numerical modelling

Abstract

The present disclosure relates to a method for refining beryllium by molten salt electrolysis, the method comprises: firstly, constructing an electrochemical system, wherein an anode chamber contains an anode molten salt electrolyte, a crude beryllium anode is inserted in the anode molten salt electrolyte, a cathode chamber contains a cathode molten salt electrolyte, a cathode is inserted in the cathode molten salt electrolyte, the anode molten salt electrolyte and the cathode molten salt electrolyte are not in contact with each other but are connected with each other via a liquid alloy at the bottom of the inside of an electrolysis cell; and applying a current for electrolysis to obtain refined solid beryllium at the cathode.

IPC Classes  ?

• C25C 3/02 - Electrolytic production, recovery or refining of metals by electrolysis of melts of alkali or alkaline earth metals
• C25C 7/02 - Electrodes; Connections thereof
• C25C 7/06 - Operating or servicing

Abstract

The present application belongs to the technical field of aluminum metallurgy, and specifically relates to a method for producing metallic aluminum and polysilicon with a high-silicon aluminum-containing resource. The method includes: pretreating the high-silicon aluminum-containing resource to obtain an aluminum-silicon oxide material; the aluminum-silicon oxide material is used to produce a metallic aluminum product and a copper-aluminum-silicon alloy with silicon enriched by molten salt electrolysis in a double-chamber electrolytic cell; and the copper-aluminum-silicon alloy is used to produce an aluminum-silicon alloy and/or polysilicon by molten salt electrolysis in a single-chamber electrolytic cell, and further separating the aluminum-silicon alloy by physical methods to obtain polysilicon. The present application has characteristics such as low production cost, continuous electrolysis operations, high product quality, and environmental friendliness.

IPC Classes  ?

• C25C 3/36 - Alloys obtained by cathodic reduction of all their ions
• C25B 1/33 - Silicon
• C25B 9/09 - Fused bath cells
• C25C 3/08 - Cell construction, e.g. bottoms, walls, cathodes
• C25C 3/18 - Electrolytes
• C25C 7/02 - Electrodes; Connections thereof
• C25C 7/04 - Diaphragms; Spacing elements

Abstract

A method for cyclic biochemical conversion of carbon dioxide and hot gas cogeneration in depleted oil and gas reservoirs includes: S1: selecting a target depleted oil and gas reservoir; S2: adjusting a temperature of the target depleted oil and gas reservoir to 30° C. to 70° C. and detecting whether formation water of the target depleted oil and gas reservoir contains methanogenic archaea, in which if no methanogenic archaeon is contained, then methanogenic archaea is injected and step S3 is proceeded, and if methanogenic archaea are contained, then step S3 is proceeded directly; S3: injecting a mixture of carbon dioxide and hydrogen into the target depleted oil and gas reservoir through a gas injection well; and S4: shutting down the gas injection well to wait for the methanogenic archaea to convert carbon dioxide and hydrogen into methane and exploiting the methane and heat energy in the target depleted oil and gas reservoir.

IPC Classes  ?

• C12P 5/02 - Preparation of hydrocarbons acyclic
• C09K 8/582 - Compositions for enhanced recovery methods for obtaining hydrocarbons, i.e. for improving the mobility of the oil, e.g. displacing fluids characterised by the use of bacteria
• C09K 8/594 - Compositions used in combination with injected gas
• E21B 41/00 - Equipment or details not covered by groups

Abstract

The present disclosure provides an electrochemical method for the separation of zirconium and hafnium, using an electrolytic cell equipped with an anode chamber and a cathode chamber, wherein the anode chamber and the cathode chamber are separated by a liquid alloy. In particular, the liquid alloy comprises a crude zirconium and a matrix metal with the metal activity lower than zirconium. After the electrolysis reaction is started, since the metal activity series in the liquid alloy is: hafnium>zirconium>>matrix metal, the hafnium in the liquid alloy is oxidized prior to the zirconium, the hafnium in ionic form migrates into the cathode electrolyte in the cathode chamber, leading to a continuous decrease of hafnium content in the liquid alloy, whereas the zirconium remains in the liquid alloy. Accordingly, deep separation of zirconium from hafnium is achieved, and therefore, nuclear-grade zirconium products can be prepared.

IPC Classes  ?

• C25C 3/26 - Electrolytic production, recovery or refining of metals by electrolysis of melts of titanium, zirconium, hafnium, tantalum or vanadium

Abstract

Provided is a beam-column joint of a prefabricated self-centering RC (Reinforced Concrete) frame based on an SMA (Shape Memory Alloy) material, including an RC precast column, an RC precast beam, and self-centering energy dissipation dampers arranged, and a friction energy dissipation damper. The self-centering energy dissipation damper includes an SMA kernel, an upper restraint cover plate, a lower restraint cover plate, a column-end connection reinforcing plate and a beam-end connection reinforcing plate, and a set energy dissipation gap is reserved between the SMA kernel and the upper restraint cover plate. The friction energy dissipation damper includes an in-column embedded connecting plate and a beam-end embedded connecting plate. The in-column embedded connecting plate and the beam-end embedded connecting plate each are provided with a primary connecting hole and secondary connecting holes, and each of the secondary connecting holes on the beam-end embedded connecting plate is an arc-shaped elongated hole.

IPC Classes  ?

• E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground

Abstract

The present application relates to a method for preparing metallic titanium by molten salt electrolysis reduction of titanium dioxide, the method includes: constructing an electrochemical system, including an anode chamber filled with an anodic molten salt electrolyte and inserted with an anode, and a cathode chamber filled with a cathodic molten salt electrolyte and inserted with a cathode, where the anodic molten salt electrolyte and the cathodic molten salt electrolyte are connected through a liquid alloy accommodated at an inner bottom of the electrolytic cell without contacting with each other; and adding titanium dioxide to the anode chamber, and energizing for electrolysis to obtain metallic titanium at the cathode. The method of the present application has advantages such as low requirements for the titanium dioxide raw material, simple process flow, low energy consumption, environmental friendliness, and direct acquisition of high-purity metallic titanium.

IPC Classes  ?

• C25C 3/28 - Electrolytic production, recovery or refining of metals by electrolysis of melts of titanium, zirconium, hafnium, tantalum or vanadium of titanium
• C25C 7/02 - Electrodes; Connections thereof

Abstract

The present invention provides a method for preparing a copper polylipoate coating on the surface of a cardiovascular and cerebrovascular stent material and a cardiovascular and cerebrovascular stent material comprising the coating. The method is mainly used for solving the problem of endothelialization delay of existing cardiovascular and cerebrovascular drug eluting stents. The method comprises two steps of pre-treating a cardiovascular and cerebrovascular stent material and preparing a copper polylipoate coating. The technical route thereof is as follows: an anhydrous ethanol solution containing lipoic acid and anhydrous copper chloride is dip-coated/spin-coated/spray-coated onto the surface of a cardiovascular and cerebrovascular stent material, and then the surface is dried, thus completing the preparation of the copper polylipoate coating. The copper polylipoate coating on the surface of the cardiovascular and cerebrovascular stent material obtained in the present application is compact and uniform, exhibits high adhesive force, and is capable of inhibiting the adhesion and denaturation of platelets and significantly promoting the growth and adhesion of endothelial cells. The method in the present invention features high operability and good effect and is expected to replace existing cardiovascular and cerebrovascular drug eluting stents loaded with rapamycin and a derivative thereof, such that a new method is provided for surface coating of cardiovascular and cerebrovascular stent materials.

IPC Classes  ?

• A61L 27/34 - Macromolecular materials
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/30 - Inorganic materials

Abstract

A method for preparing a poly(thioctic acid)-copper coating (poly(TA-Cu)) on a surface of a cardiovascular stent material includes: grinding a cardiovascular stent material with sandpaper until the surface of the cardiovascular stent material is flat and smooth, rinsing the cardiovascular stent material with deionized water and anhydrous ethanol in sequence, and drying the cardiovascular stent material to obtain a pre-treated cardiovascular stent material; dissolving thioctic acid in an alcoholic solvent, adding anhydrous copper chloride to a mixed solution of thioctic acid and the alcoholic solvent, stirring the mixed solution, to yield a precursor solution; treating the pre-treated cardiovascular stent material with the precursor solution, and drying, thus forming a poly(thioctic acid)-copper coating on the surface of the pre-treated cardiovascular stent material. The concentration of thioctic acid in the alcoholic solvent is 0.1-0.3 g/mL, and the molar ratio of anhydrous copper chloride to thioctic acid monomer is 1:100-5000.

IPC Classes  ?

• A61L 31/08 - Materials for coatings

Abstract

The present invention provides a continuous rolling temperature control process for high-flux continuous casting and rolling of an aluminum alloy continuous cast slab, comprising a continuous casting machine, a through-beam laser transmitter K, a controller, a spraying head, and a spraying system. A liquid aluminum alloy metal melt passes through the continuous casting machine and then is cooled and solidified to form a continuous cast slab; the movement direction of the continuous cast slab is controlled by a lifting table, and then the continuous cast slab penetrates into the interior of a traction machine and extends to a continuous rolling machine; and the through-beam laser transmitter K is arranged between the continuous casting machine and the traction machine. According to the present invention, comprehensive performance indexes required by different series of aluminum alloys under high-flux continuous casting and rolling conditions are distinguished, and the continuous rolling temperatures of continuous cast slabs of different series of high-flux continuous cast and rolled aluminum alloy plates are correspondingly designed and controlled. A preset continuous rolling temperature enables the comprehensive performance of different series of aluminum alloys to reach a product quality standard, reduces interior defects and alleviates the problems of segregation and the like. The flow velocity (or flow capacity) of the spraying system can reduce the loss of a cooling liquid (an emulsion), thereby reducing the cost, and achieving the purpose of energy conservation and emission reduction.

IPC Classes  ?

• B21B 37/74 - Temperature control, e.g. by cooling or heating the rolls or the product
• B21B 3/00 - Rolling materials of special alloys so far as the composition of the alloy requires or permits special rolling methods or sequences
• B21B 1/46 - Metal rolling methods or mills for making semi-finished products of solid or profiled cross-section; Sequence of operations in milling trains; Layout of rolling-mill plant, e.g. grouping of stands; Succession of passes or of sectional pass alternations for rolling metal immediately subsequent to continuous casting

Abstract

The disclosure belongs to the technical field of heat insulation materials, and discloses an in-situ microfibrillated reinforced polymer composite heat insulation foam material as well as a preparation method and application thereof. This disclosure adopts a polypropylene matrix, a fiber-forming polymer, an elastomer and an antioxidant as a foam material. The foaming material is subjected to a primary melt blending process and a hot stretching process first, then subjected to a secondary melt blending process and cooling granulation and subjected to a pressing process, and a composite board is obtained. The composite board is subjected to supercritical fluid foaming process, and a composite heat insulation foam material is obtained.

IPC Classes  ?

• B29C 48/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
• B29B 7/48 - Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
• B29C 44/34 - Component parts, details or accessories; Auxiliary operations
• B29C 48/40 - Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws, e.g. twin screw extruders
• B29K 21/00 - Use of unspecified rubbers as moulding material
• B29K 23/00 - Use of polyalkenes as moulding material
• B29K 31/00 - Use of polyvinylesters as moulding material
• B29K 67/00 - Use of polyesters as moulding material
• B29K 101/12 - Thermoplastic materials
• B29K 105/04 - Condition, form or state of moulded material cellular or porous
• B29K 105/14 - Condition, form or state of moulded material containing reinforcements, fillers or inserts of short lengths, e.g. chopped filaments, staple fibres or bristles oriented

Abstract

An MXene-based conductive ink having an adjustable work function, a preparation method therefor, and an application thereof in thin film transistors. The MXene-based conductive ink with an adjustable work function comprises a two-dimensional MXene material and a dopant, wherein the mass percentage of the two-dimensional MXene material within the two-dimensional MXene material and dopant is greater than or equal to 98%, and the mass percentage of the dopant within the two-dimensional MXene material and dopant is 0.02% to 2%. The work function of the MXene-based conductive ink can be controlled within a relatively wide range of 4.88 to 5.66 eV, thereby greatly expanding the types of substrate materials which can be selected during printing of the MXene-based conductive ink. Moreover, the MXene-based conductive ink having an adjustable work function can likewise be printed as a high-resolution electrode array via silk-screen printing, and the preparation process is simple and easy to operate, with broad applications in printing flexible thin film transistors.

IPC Classes  ?

• C09D 11/52 - Electrically conductive inks

Abstract

Provided is a new-type cis-replicon construct for efficiently expressing a target protein, which comprises an RNA polymerase coding unit and a target protein coding unit. The replicon construct can drive the replication of the target protein coding unit and reduce or avoid the replication and expression of the RNA polymerase, thereby effectively improving the expression of the target protein and reducing the expression of the non-target protein.

IPC Classes  ?

• A61K 39/12 - Viral antigens
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The present invention provides a rabies virus monoclonal antibody 2F2 and universal rabies virus antibody rapid detection test paper and belongs to the technical field of biological detection. An amino acid sequence of the monoclonal antibody 2F2 is shown as SEQ ID No. 1. The monoclonal antibody 2F2 provided by the present invention specifically binds to rabies virus G proteins, and preparation of the monoclonal antibody 2F2 into test paper has the advantages of rapidity, accuracy, sensitivity, specificity and low cost.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

Disclosed are a pyrrolopyrimidine derivative as an RSK inhibitor and use thereof. Specifically, disclosed are a compound represented by formula I, a pharmaceutical composition containing the compound of formula I, and use of the compound in the preparation of a medicament for treating an RSK-related disease or inhibiting RSK.

IPC Classes  ?

• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
• C07D 487/04 - Ortho-condensed systems
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a pyridonopyrimidine derivative as an RSK protein kinase inhibitor and use thereof. Specifically, the present invention relates to a compound represented by formula I, a pharmaceutical composition comprising the compound represented by formula I, and use of the compound in preparing a medicament for treating an RSK-related disease or inhibiting RSK. Formula I.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• C07D 475/00 - Heterocyclic compounds containing pteridine ring systems
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

The disclosure relates to the technical field of new foaming materials, in particular to a preparation method of a microporous foam material with oriented cells, which comprises the following steps: (1) melting and mixing raw materials for preparing a polymer composite material, and then carrying out hot stretching to obtain polymer composite fibers; the raw materials comprise a polymer matrix, a fiber-forming phase substance and a processing aid; (2) arranging the polymer composite fibers prepared in the step (1) in the same direction, and performing hot pressing to obtain a polymer composite board with oriented fibers; and (3) carrying out supercritical fluid foaming on the polymer composite board prepared in the step (2) to obtain the microporous foam material with oriented cells.

IPC Classes  ?

• C08J 9/228 - Forming foamed products
• C08J 9/08 - Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a chemical blowing agent developing carbon dioxide
• C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof

Abstract

Provided is an airflow disturbance type carbon fiber spreading device. The device includes an unwinding module, an unwinding tension control module, an airflow disturbance spreading module, a winding tension stabilizing module, a deviation correction module and a winding module which are sequentially arranged along a feeding direction. The spreading mechanism includes an airflow disturbance spreading module, the airflow disturbance spreading module includes two airflow disturbance spreading assemblies, each airflow disturbance spreading assembly includes a centrifugal fan, the centrifugal fan communicates with the bottom of an airflow duct, and three spreading guide shafts are arranged side by side on the top of the airflow duct. A tension adjusting assembly is provided between the airflow disturbance spreading assemblies. A seventh spreading guide shaft (13) is located at the upper port of an airflow duct I (25) and is connected to a slider module II (34).

IPC Classes  ?

• D02J 1/18 - Separating or spreading

Abstract

The present disclosure provides a method for producing value-added by-product yellow phosphorus slag through an unconventional electric furnace process, derived from yellow phosphorus. This method is related to the technical field of comprehensive utilization of mineral resources. The disclosed method involves the following steps: mixing mid-low-grade phosphate rock, silica, coke, and a cosolvent to create a blended material, subjecting the blended material to high-temperature reduction in a yellow phosphorus electric furnace to yield yellow phosphorus and water-quenched slag, and then drying the water-quenched slag using yellow phosphorus tail gas to obtain the yellow phosphorus slag. According to this disclosure, a P2O5—CaO—SiO2—MgO—R multi-component system is established using the blended material.

IPC Classes  ?

• C01B 25/027 - Preparation of phosphorus of yellow phosphorus
• C01B 25/047 - Purification of phosphorus of yellow phosphorus
• C05B 5/00 - Thomas phosphate; Other slag phosphates
• C05B 7/00 - Fertilisers based essentially on alkali or ammonium orthophosphates
• C05B 19/00 - Granulation or pelletisation of phosphatic fertilisers other than slag

Abstract

A lotus leaf derived biochar loaded with ZIF-67, and a preparation method therefor and an application method thereof are provided, which relate to the field of environmental protection wastewater treatment technologies. The preparation method includes: adding a pretreated lotus leaf carrier and ZIF-67 to methanol as solvent, to obtain a solution, performing an ultrasonic dispersion process on the solution, standing the solution after performing the ultrasonic dispersion process to perform a self-assembly reaction to thus obtain a reacted solution, and drying the reacted solution to obtain the lotus leaf derived biochar loaded with the ZIF-67. Recyclability and reusability of the ZIF-67 are effectively improved by the lotus leaf derived biochar loaded with ZIF-67, and organic pollutants in aqueous solution are degraded by effectively activating peroxymonosulfate.

IPC Classes  ?

• C10B 53/02 - Destructive distillation, specially adapted for particular solid raw materials or solid raw materials in special form of cellulose-containing material

Abstract

An ultra-high performance concrete (UHPC) with waste brick powder and preparation method and application thereof are provided, which relates to the technical field of concrete. The preparation method includes the following steps: stimulating activity of a brick powder by a method of mechanically stimulating activity to obtain waste brick powder; and preparing UHPC according to a mass ratio of cement to waste brick powder of 5:5-7:3 to obtain the UHPC with waste brick powder. The UHPC is prepared by treating waste bricks from construction waste (mechanically stimulating activity) to make waste brick powder with activity, therefore partially replacing cement. The UHPC is applied in a construction field.

IPC Classes  ?

• C04B 18/16 - Waste materials; Refuse from building or ceramic industry
• C04B 18/08 - Flue dust
• C04B 18/14 - Waste materials; Refuse from metallurgical processes
• C04B 14/48 - Metal
• C04B 7/19 - Portland cements
• C04B 28/04 - Portland cements
• C04B 24/26 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C04B 20/02 - Treatment
• C04B 103/32 - Superplasticisers
• C04B 103/30 - Water reducers, plasticisers, air-entrainers

Abstract

The present invention provides a monoclonal antibody 2F2 of the rabies virus, and universal rabies virus antibody rapid detection test paper, and belongs to the technical field of biological detection. The amino acid sequence of the monoclonal antibody 2F2 is shown in SEQ ID NO. 1. The monoclonal antibody 2F2 provided in the present invention specifically binds to rabies virus G protein. The monoclonal antibody 2F2 is prepared into a test paper strip which has the advantages of rapidness, accuracy, sensitivity, specificity and low cost.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• G01N 33/577 - Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies
• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/558 - Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

Abstract

The present invention belongs to the field of sodium-ion batteries, relates to a hard-carbon negative electrode, and particularly relates to an interface-modified hard-carbon negative electrode material/negative electrode of a sodium-ion battery, and a preparation method for an interface-modified hard-carbon negative electrode material/negative electrode and an application thereof. The surface of a spherical or block-shaped commercial hard carbon material or the surface of a negative electrode prepared from the hard carbon material is coated with a metal organic complex thin film which is formed by coordination polymerization of a metal center and organic molecules on the surface of the carbon material. The method comprises: soaking, into an organic-molecular solution and a metal-ion solution sequentially, a hard carbon material or a negative electrode prepared from the hard carbon material, and then drying same to obtain an interface-modified hard-carbon negative electrode prepared from the hard carbon material or an interface-modified hard-carbon negative electrode. The present invention innovatively introduces a metal organic complex thin film, such that the ionic conductivity and stability of an interface is promoted, and the sodium-storage specific capacity of a hard-carbon negative electrode, the rate performance of same and the cycle stability of same are significantly improved, thereby effectively solving the existing dilemma of negative electrodes of sodium-ion batteries. Moreover, the preparation method is simple and is suitable for large-scale operation, and has wide application prospects.

IPC Classes  ?

• H01M 4/36 - Selection of substances as active materials, active masses, active liquids

Abstract

The present invention belongs to the field of genetic engineering. Provided is a DNA molecule comprising plant-induced secretory expression cassettes and regulatory elements thereof. The DNA molecule comprises four expression cassettes, each of the expression cassettes comprising a promoter, a 5'UTR linked to the promoter, a signal peptide-encoding gene linked to the 5'UTR, a functional gene linked to the signal peptide-encoding gene, a 3'UTR linked to the functional gene, and a terminator linked to the 3'UTR. The promoter, the 5'UTR, the 3'UTR, and the terminator are all derived from a jasmonic acid-induced expression gene, and the signal peptide is derived from a secretory protein. The nucleotide sequence of the functional gene in each of the expression cassettes is different, and the nucleotide sequences of the promoter, the 5'UTR, the 3'UTR, the signal peptide-encoding gene, and the terminator in each of the expression cassettes are different or identical. The DNA molecule can be applied to any plant.

IPC Classes  ?

• C12N 15/09 - Recombinant DNA-technology
• A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The present disclosure disclosed recombinase aided amplification (RAA) primers and kits for the detection of hepatitis c virus. Nucleotide sequences of the RAA primers include: an upstream primer: 5′-FITC-CTTGGGATATGATGATGAACTGGTCACCTAC-3′ (SEQ ID NO. 1); and a downstream primer: 5′-Biotin-AAGAGTAGCATCACAATCAGAACCTTAGCC-3′ (SEQ ID NO. 2). The HCV detection by using the RAA primers screened by the present disclosure has good specificity and high sensitivity (at least 10 copies/μL can be detected). The RAA primers can be used to prepare an HCV detection kit and construct an RAA amplification system. And combined with a lateral flow chromatography technology, the present disclosure can achieve rapid and low-cost detection of HCV and visual result judgment, no complex professional background is required, the use process is convenient and fast, and the detection results are safe and reliable.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present invention provides a method for preparing an electrothermal heating sheet by using leftover material of braided carbon fiber, comprising the following steps: cutting off clumps of disordered leftover material of braided carbon fiber into chopped carbon fibers; respectively cleaning with acetone and deionized water, and drying; preparing a corresponding dispersion; adding the chopped carbon fibers into the dispersion and fully dispersing; performing suction filtration by using a double-layer metal filter screen, and drying after suction filtration to obtain a chopped carbon fiber felt; cutting the chopped carbon fiber felt, adhering electrodes at two ends of the chopped carbon fiber felt, and using TPU sheets to cover the front and back surfaces of the carbon fiber felt to form a heating sheet product provided with an electrothermal performance and an electromagnetic shielding performance. If the leftover materials of the braided carbon fiber and the leftover materials produced by cutting during the preparation process are directly discarded as waste, not only will a large amount of material be wasted, but the waste material may also greatly pollute the environment. The method makes full use of the leftover material of braided carbon fiber and has low manufacturing costs, and the prepared product has excellent electrothermal and electromagnetic shielding performances.

IPC Classes  ?

• H05B 3/34 - Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater flexible, e.g. heating nets or webs

Abstract

A vaccine hesitancy prediction method based on emergency vaccine is provided, including: collecting multi-dimensional variables of initial vaccine hesitancy influencing factors, screening the variables and constructing the model, and using the vaccine hesitancy prediction model to accurately identify high-risk groups of vaccine hesitancy. It can help to find the high-risk population of anti-vaccination, provide guidance for vaccination intervention, provide important technical support for the construction of “immune barrier”, and provide technical enlightenment for the prediction of vaccine hesitancy, which has certain economic and social benefits.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G06N 20/00 - Machine learning
• G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks

Abstract

A pair of piezoelectric fabric trousers capable of performing energy conversion. The piezoelectric fabric trousers comprise a body, and a flexible super capacitor and rectification module, wherein the body is composed of hip pieces and leg pieces, the body is divided into a left piece and a right piece, a waist piece is arranged at the top end of the body, a drawstring is arranged at an interface position of the leg pieces of the body, a button for easy wearing is arranged at an interface position of the hip pieces of the body, and the flexible super capacitor and rectification module is mounted on an outer side wall of the waist piece. According to the present device, piezoelectric fabrics are woven into pieces, two body pieces are bound to the hip and legs of a user to form the piezoelectric fabric trousers, which are capable of converting mechanical motion energy into potential energy. The button for easy wearing can be connected by means of pressing, so as to be buttoned and unbuttoned more quickly; and cooperatively, the drawstring with one end capable of being pulled to tighten the entire body is provided, so that the trousers can be quickly loosened and tightened, thereby obviously improving the property of being easy to wear of the wearable energy conversion fabric.

IPC Classes  ?

• A41D 1/06 - Trousers

Abstract

An airflow disturbance-type carbon fiber widening equipment, comprising an unwinding module, an unwinding tension control module, an airflow disturbance widening module, a winding tension stabilizing module, a deviation correction module, and a winding module which are sequentially provided in a feeding direction. A widening mechanism comprises the airflow disturbance widening module; the airflow disturbance widening module comprises two sets of airflow disturbance widening assemblies; each set of airflow disturbance widening assembly comprises a centrifugal fan; the centrifugal fans are communicated with the bottoms of airflow ducts; three sets of widening guide shafts are provided side by side at the top of each airflow duct; a tension adjusting assembly is provided between the two sets of airflow disturbance widening assemblies; the widening guide shafts and the tension adjusting assembly all match a carbon fiber (6); a widening guide shaft VII (13) is located at an upper port of an airflow duct I (25) and is connected to a sliding block module II (34); and when the widening guide shaft VII (13) moves along its own axial direction, a transverse force is applied to the carbon fiber to facilitate the widening of the carbon fiber. According to the carbon fiber widening equipment, airflows are provided by using frequency-adjustable centrifugal fans, so that stable negative pressure is formed at the upper ends of the airflow ducts, and the surrounding air forms a stable airflow under the action of the pressure; in addition, with the assistance of the widening guide shafts, a carbon fiber tow is uniformly dispersed.

IPC Classes  ?

• D02J 1/18 - Separating or spreading
• B65H 59/38 - Adjusting or controlling tension in filamentary material, e.g. for preventing snarling; Applications of tension indicators by regulating speed of driving mechanism of unwinding, paying-out, forwarding, winding, or depositing devices, e.g. automatically in response to variations in tension
• B65H 59/40 - Applications of tension indicators

Abstract

The present invention provides a multi-tow carbon fiber broadening and pre-impregnation system, used for solving the technical problems of large thickness, high porosity and the like of a prepreg tape product caused by low broadening ratio and insufficient pre-impregnation in the existing thermoplastic prepreg tape production process. The system of the present invention comprises a filament unwinding module, a filament doubling module, an airflow broadening module, a process deviation rectifying module, a traction module, a slurry impregnation module, an infrared melting module, a hot-pressing shaping module, a floating roller module, a cutting module, a scrap collecting module, a winding deviation rectifying module, and a winding module which are sequentially arranged in the feeding direction. The filament unwinding module comprises at least two sets of filament unwinding assemblies, and carbon fibers are placed on the filament unwinding assemblies. In the present invention, damage-free broadening of the carbon fibers is realized by adopting an airflow method, and full pre-impregnation of resins to the broadened carbon fibers is realized by adopting a powder slurry method, thereby producing a thin and high-performance thermoplastic carbon fiber prepreg tape, and improving designability of thermoplastic prepreg tape laying and mechanical properties of a thermoplastic composite product.

IPC Classes  ?

• B29B 15/14 - Coating or impregnating of reinforcements of indefinite length of filaments or wires

Abstract

An intelligent decision-making method for maintaining urban underground sewer network includes steps of: analyzing with a sewer network functional defect three-dimensional instantaneous hydraulic model; calibrating parameters by finite element fitting analysis and full-scale test, and verifying accuracy of the sewer network functional defect three-dimensional instantaneous hydraulic model; combining node water level iteration method, Preissmann slit method, Godunov finite volume method and unstructured grid to rebuild a surface-subsurface one-two-dimensional coupled connection model; using R language, dynamic library linking technology, and long-short-term memory neural network method of multi-source data samples for engineering secondary development of the surface-subsurface one-two-dimensional coupled connection model, and obtaining urban sewer network functional defect conditions with waterlogging result labels; and establishing a multi-objective planning intelligent decision-making model for sewer network maintenance and a solving method thereof. The present invention provides intelligent, accurate and scientific management for urban sewer network.

IPC Classes  ?

• G06F 30/28 - Design optimisation, verification or simulation using fluid dynamics, e.g. using Navier-Stokes equations or computational fluid dynamics [CFD]

Abstract

A side-ledge melting process simulation device for an aluminum electrolysis cell, and a method of using same. The simulation device comprises a simulation device body, an air cooling system, and a temperature control system. The simulation device body has an inverted T-shaped structure, and comprises a base (1) and a rectangular cold wall (2) perpendicular to the base (1). A rectangular cooling cavity (4) is provided within the cold wall (2), and a sealing rod (3) is arranged at the top of the cooling cavity (4). The air cooling system is connected to the cooling cavity (4) and is configured to cool the cooling cavity (4). The temperature control system is arranged in the cold wall (2), and in a molten electrolyte (9) at the periphery of the simulation device body, and is used to measure the temperatures of the cold wall (2) and the molten electrolyte (9). In the invention, a simulation device using a side-ledge growth model for a planar cold wall is constructed according to planar side-walled heat dissipation structures of actual aluminum electrolysis cells. The simulation device can realistically simulate heat dissipation states during operation of an electrolytic cell, and electrolyte precipitation and solidification processes on the simulation device are similar to actual side-ledge growth processes, thereby improving simulation experiment performance.

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 1/28 - Preparing specimens for investigation
• G05D 23/22 - Control of temperature characterised by the use of electric means with sensing elements having variation of electric or magnetic properties with change of temperature the sensing element being a thermocouple

Abstract

Provided in the present invention are a zinc-doped indium oxide powder, a sputtering target material, and preparation methods therefor, belonging to the technical field of new materials. In the present invention, a precursor powder of a zinc-doped indium oxide is synthesized in one step using a hydrothermal method, the reaction system is stable, and the resulting zinc-doped indium oxide powder has a high purity, a uniform crystal form distribution, good dispersity and a high crystallinity; and a sputtering target material resulting from sintering of the powder has a small grain size, a uniform distribution and a high density. The present application is simple and convenient in the whole process from the preparation of the powder to forming and sintering processes, low in terms of cost, and suitable for industrial production.

IPC Classes  ?

• C04B 35/01 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides
• C04B 35/622 - Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
• C23C 14/08 - Oxides
• C23C 14/34 - Sputtering
• C23C 14/35 - Sputtering by application of a magnetic field, e.g. magnetron sputtering

Abstract

Disclosed in the present invention are an RAA primer and kit for detecting a hepatitis C virus (HCV), and an application of an RAA primer. According to the present invention, an HCV detection RAA primer obtained by means of screening is good in specificity and good in sensitivity (the lowest detectable sensitivity is 10 copies/μL), can be used for preparing an HCV detection kit and constructing an RAA amplification system, and realizes rapid and low-cost detection of the HCV and visual result determination by combining a lateral flow chromatography technology without a complex professional background, and thus, a use process is convenient and rapid, and a detection result is safe and reliable.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
• C12Q 1/6844 - Nucleic acid amplification reactions
• G01N 33/558 - Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

Disclosed are a micron-sized porous sodium ferrous sulfate/carbon composite positive electrode material, and a sodium ion battery or a sodium battery prepared from same. The composite material of the present invention is a sodium ferrous sulfate/carbon composite material containing/not containing a metal doping element, is prepared by using a coprecipitation and solid-phase calcination method, has a particle size of 2-30 μm, has a porous structure, and is formed by tightly packing 80-200 nm primary particles that are tightly coated by amorphous carbon. The surface layer of the micron particles is covered by a reduced graphene thin layer to form a three-dimensional conductive network. The micron-sized particle positive electrode material has a higher tap density, which helps to improve the volume energy density of the battery. The material is used as the positive electrode of a sodium ion battery or a sodium battery, and has the advantages of rich raw materials, low costs, a high working voltage, a good rate performance and a good cycle stability, and the preparation process for the material is simple. The sodium ion battery or the sodium battery of the present invention has the advantage of a high energy density and has bright market application prospects.

IPC Classes  ?

• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates

Abstract

The present disclosure discloses a Fiber Reinforced Polymer/Plastic (FRP) composite spiral stirrup confined concrete column and a compression design method. The FRP composite spiral stirrup includes an internal FRP spiral stirrup and an external FRP square stirrup. In the form of the FRP composite spiral stirrup, effective transverse stress transfer is established by effectively binding stirrups, which can give full play to the mechanical properties of the FRP bars, provide “dual confinement” for core concrete, and greatly improve the peak stress of the core concrete. Confining mechanisms of the FRP composite spiral stirrup to the concrete in different areas are analyzed, a confinement model and a bearing capacity calculation method for the FRP composite spiral stirrup confined concrete column are proposed, and a design method for the FRP composite spiral stirrup confined concrete column is proposed after an accurate calculation method for the bearing capacity is obtained.

IPC Classes  ?

• E04C 5/07 - Reinforcing elements of material other than metal, e.g. of glass, of plastics, or not exclusively made of metal
• E04C 3/34 - Columns; Pillars; Struts of concrete or other stone-like material, with or without permanent form elements, with or without internal or external reinforcement, e.g. metal coverings
• G06F 30/13 - Architectural design, e.g. computer-aided architectural design [CAAD] related to design of buildings, bridges, landscapes, production plants or roads

Abstract

This invention relates to a method of carbothermic process of magnesium production and co-production of calcium carbide, which is particularly suitable for carbothermic process of magnesium production with a mixture of magnesium oxide and calcium oxide as a raw material and carbon as a reducing agent. A mixed powder containing magnesium oxide, calcium oxide and a carbon reducing agent is prepared. The mixed powder is processed into a pelletized furnace feed material, which is placed into a reactor equipped with a heat source. With an absolute pressure P in the reactor being set within the range of 1000 Pa≤P≤atmospheric pressure or to a slightly positive pressure and a reaction temperature T within the range of 11 lg2P+71 lgP+1210° C.

IPC Classes  ?

• C22B 26/22 - Obtaining magnesium

Abstract

The invention discloses a high-throughout continuous casting and rolling Al—Mg—Mn alloy plate for ships and the preparation process thereof. The chemical components of the Al—Mg—Mn alloy in percentage by mass percentage are: Mg: 0.80-2.80%, Mn: 0.00-1.40%, Zr: 0.10-0.50%, Cr: 0.15-0.35%, Sr: 0.00-0.10%, Er: 0.00-0.60%, Si: 0.10-0.40%, Cu: 0.01-0.10%, Ti: 0.01-0.05%, Fe: 0.00-0.40% and the rest is Al. The preparation processes mainly include smelting and melt treatment, continuous casting, continuous rolling and cold rolling. The invention solves the problems of easy segregation, low strength and toughness and poor formability in the preparation of high-throughout continuous casting and rolling Al—Mg—Mn plates for ships.

IPC Classes  ?

• C22C 21/06 - Alloys based on aluminium with magnesium as the next major constituent

Abstract

Provided are a molecular marker group of a human esophageal squamous cell carcinoma and an application of the molecular marker group. The molecular marker group is: a molecular marker group for the esophageal squamous cell carcinoma to be divided into a differentiated type, an immunogenic type, a metabolic type, and a stemness type: the differentiated type: LCE3D, CDSN, KLK5, SPRR2G, and DSG1; the immunogenic type: MS4A1, CD79A, CXCL9, MZB1, and IDO1; the metabolic type: GSTA1, ADH7, UGT1A3, and ALDH3A1; and the stemness type: WFDC2, PEG10, SFRP1, LGR6, and VWA2; and an NK cell surface molecular marker group for the esophageal squamous cell carcinoma to be divided into poor prognosis and drug insensitive subtypes.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

A method for preparing large size beta-type ammonium tetramolybdate monocrystal particle includes industrial ammonium molybdate, ammonia, de-ionized water are used to prepare ammonium molybdate solution with concentration of 0.2˜0.6 g/ml; pH is adjusted to 5˜7, temperature is adjusted to the first temperature of 70˜90° C. to obtain the first ammonium molybdate solution; beta-type ammonium tetramolybdate crystal seed is put into crystallization container, and the first ammonium molybdate solution is poured in the crystallization container, to form crystallization system; the crystallization system stands still at room temperature, naturally cooling, the beta-type ammonium tetramolybdate crystal seed grows into large size beta-type ammonium tetramolybdate monocrystal particle. A beta-type ammonium tetramolybdate crystal seed is obtained by constant-temperature crystallization at 70˜90° C. The obtained beta-type ammonium tetramolybdate crystal seed is put stewing in the first ammonium molybdate solution and is naturally cooling to produce large size beta-type ammonium tetramolybdate monocrystal particle forms.

IPC Classes  ?

• C30B 7/08 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by cooling of the solution
• C30B 33/02 - Heat treatment

Abstract

22222 in supercritical carbon dioxide conditions, and can generate a stronger and more stable magnetic response compared with a traditional defect-induced local magnetic moment; in the whole ferromagnetic structure induction process, the preparation technology is environmentally friendly and pollution-free, having great application prospects in the field of magneto-optical and magneto-electric devices.

IPC Classes  ?

• C01G 31/02 - Oxides

Abstract

The present application relates to a method for preparing metal titanium by molten salt electrolytic reduction of titanium dioxide, comprising: first constructing an electrochemical system in which an anode molten salt electrolyte is contained and an anode is inserted in an anode chamber, a cathode molten salt electrolyte is contained and a cathode is inserted in a cathode chamber, and the anode molten salt electrolyte and the cathode molten salt electrolyte are not in contact with each other but are connected by means of a liquid alloy at the bottom of an electrolytic cell, adding titanium dioxide into the anode chamber, and enabling electrification for electrolysis, thereby obtaining metal titanium on the cathode. The method of the present application has the advantages of having low requirements for the titanium dioxide raw material and being simple in process, low in energy consumption, environmentally friendly, and capable of direct obtaining of high-purity metal titanium.

IPC Classes  ?

• C25C 3/28 - Electrolytic production, recovery or refining of metals by electrolysis of melts of titanium, zirconium, hafnium, tantalum or vanadium of titanium
• C25C 7/06 - Operating or servicing

Abstract

The present application belongs to the technical field of aluminum metallurgy, and specifically relates to a method for producing metal aluminum and polysilicon by using a high silicon aluminum-containing resource. Firstly, a high silicon aluminum-containing resource raw material is used to obtain, by means of a pretreatment process an aluminum-silicon oxide material, then a metal aluminum product and a silicon-enriched copper-aluminum-silicon alloy are produced by means of molten salt electrolysis in a double-chamber electrolytic cell, the copper-aluminum-silicon alloy produces, in a single-chamber electrolytic cell by means of molten salt electrolysis, an aluminum-silicon alloy or/and polysilicon; and the aluminum-silicon alloy is further separated by means of a physical method to obtain polysilicon. The present application has the features of having low production costs, continuous electrolysis operations, high product quality, and being clean and environmentally-friendly, and the like.

IPC Classes  ?

• C25C 3/06 - Electrolytic production, recovery or refining of metals by electrolysis of melts of aluminium
• C25B 1/33 - Silicon

Abstract

The present application belongs to the technical field of aluminum metallurgy, and specifically relates to a method for producing metallic aluminum and polysilicon with a high-silicon aluminum-containing resource. The method includes: pretreating the high-silicon aluminum-containing resource to obtain an aluminum-silicon oxide material; the aluminum-silicon oxide material is used to produce a metallic aluminum product and a copper-aluminum-silicon alloy with silicon enriched by molten salt electrolysis in a double-chamber electrolytic cell; and the copper-aluminum-silicon alloy is used to produce an aluminum-silicon alloy and/or polysilicon by molten salt electrolysis in a single-chamber electrolytic cell, and further separating the aluminum-silicon alloy by physical methods to obtain polysilicon. The present application has characteristics such as low production cost, continuous electrolysis operations, high product quality, and environmental friendliness.

IPC Classes  ?

• C25C 3/06 - Electrolytic production, recovery or refining of metals by electrolysis of melts of aluminium
• C25B 1/33 - Silicon

Abstract

The present application relates to a method for refining beryllium by means of molten salt electrolysis. The method comprises: firstly, constructing an electrochemical system, wherein an anode chamber contains an anode molten salt electrolyte, a crude beryllium anode is inserted in the anode chamber, a cathode chamber contains a cathode molten salt electrolyte, a cathode is inserted in the cathode chamber, the anode molten salt electrolyte and the cathode molten salt electrolyte are not in contact with each other and are connected with each other via a liquid-state alloy at the bottom of the inside of an electrolysis cell; and energizing same for electrolysis to obtain refined solid-state beryllium at the cathode. By means of the method of the present application, impurities can be effectively removed from crude beryllium, the resulting metal beryllium has a high purity, no evacuation for a vacuum is needed during the preparation process, there is no need for operation in an oxygen-free environment, the reaction conditions are easy to achieve, and the method is an efficient beryllium refining method.

IPC Classes  ?

• C25C 3/02 - Electrolytic production, recovery or refining of metals by electrolysis of melts of alkali or alkaline earth metals
• C25C 7/02 - Electrodes; Connections thereof

Abstract

Provided in the present application is an electrochemical method for separating zirconium from hafnium using an electrolytic cell having an anode chamber and a cathode chamber, wherein the anode chamber and the cathode chamber are separated by a liquid alloy. In particular, the liquid alloy comprises crude zirconium and a melt metal with the metal activity lower than that of zirconium. After an electrolysis reaction is started, since the metal activity sequence in the liquid alloy is: hafnium > zirconium > > melt metal, the hafnium in the liquid alloy is preferentially oxidized by the zirconium, and the hafnium enters an electrolyte in the cathode chamber in an ionic form, resulting in the hafnium content in the liquid alloy continuously decreasing while the zirconium remains in the liquid alloy. Accordingly, deep separation of zirconium from hafnium is achieved, and therefore, a nuclear-grade zirconium product can be prepared.

IPC Classes  ?

• C25C 3/26 - Electrolytic production, recovery or refining of metals by electrolysis of melts of titanium, zirconium, hafnium, tantalum or vanadium
• C25C 1/22 - Electrolytic production, recovery or refining of metals by electrolysis of solutions of metals not provided for in groups

Abstract

Disclosed is a cis replicon RNA construct for efficiently expressing a target protein, which comprises, in the 5'-3' direction, a 5'UTR sequence containing a 5'-cap structure; one or more nucleotide sequences encoding a replicase; a 5'-terminal recognition sequence for guiding the replication of an RNA replicon and a subgenome promoter SGP; multiple cloning sites; a target gene or heterologous nucleotide sequence, which is controlled by the subgenome promoter; a 3'-terminal recognition sequence for guiding the replication of the RNA replicon; and 3'UTR and 3'polyA for ensuring the stability of RNA and the effective replication of the target gene. The RNA replicon is constructed by means of modifying the alphavirus genome, only efficient replication and expression of the target gene are driven, and the aims of reducing the expression of a non-target protein to the maximum extent and increasing the expression of a target protein are achieved, thereby providing a basis for the effective and safe production of the target protein in an organism and realizing the potential medical application value.

IPC Classes  ?

• C12N 15/50 - Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 15/86 - Viral vectors
• C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host

Abstract

The present disclosure relates to the technical field of acetyl n-propanol preparation, and provides a high-efficiency non-polluting catalyst for preparing acetyl n-propanol, a preparation method therefor and a use method thereof. The carrier of the catalyst is an H-type ZSM-5 molecular sieve, the active component is metal Pd, and the loading amount of metal Pd is 10-20 wt%. The preparation method comprises: removing an organic templating agent in a Na-type ZSM-5 molecular sieve by means of roasting; performing H exchange on the molecular sieve to obtain the H-type ZSM-5 molecular sieve; and loading the active component to obtain the catalyst. The catalyst provided by the present disclosure has a simple preparation method. The acetyl n-propanol preparation process does not require the addition of a liquid acid, uses water as solvent, is efficient and environmentally friendly, can reach 50wt% in substrate concentration, and can be used in practical industrial applications.

IPC Classes  ?

• B01J 29/44 - Noble metals
• C07C 45/00 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
• C07C 49/17 - Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups

Abstract

Provided is a new-type cis-replicon construct for efficiently expressing a target protein, which comprises an RNA polymerase coding unit and a target protein coding unit. The replicon construct can drive the replication of the target protein coding unit and reduce or avoid the replication and expression of the RNA polymerase, thereby effectively improving the expression of the target protein and reducing the expression of the non-target protein.

IPC Classes  ?

• C12N 15/50 - Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 15/86 - Viral vectors
• C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host

Abstract

A variable-temperature and fast-sintering process for an alumina-doped zinc oxide target material is provided. Integrated degreasing and sintering processes are carried out on an alumina-doped zinc oxide biscuit, The degreasing process is carried out in air atmosphere, and a high-density alumina-doped zinc oxide target material is produced by a variable-temperature treatment during the sintering process under a state of circulating controllable mixed atmosphere. The mixed atmosphere is air and oxygen. As a result, a sintering time is greatly reduced, so that a fast-activated sintering is realized to inhibit grain growth.

IPC Classes  ?

• C04B 35/64 - Burning or sintering processes
• C23C 14/34 - Sputtering
• C23C 14/08 - Oxides
• C04B 35/453 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zinc, tin or bismuth oxides or solid solutions thereof with other oxides, e.g. zincates, stannates or bismuthates
• C04B 35/638 - Removal thereof
• C04B 35/626 - Preparing or treating the powders individually or as batches

Abstract

The present application relates to the field of rehabilitation robotics, and discloses an upper limb training system and method and a readable storage medium. The system includes a training guidance unit, a signal acquisition unit, a signal processing unit, and a training unit. The training guidance unit shows training content to a subject to guide the subject to perform motor imagery. The signal acquisition unit acquires an electroencephalography (EEG) signal of the subject and sends the EEG signal to the signal processing unit. The signal processing unit recognizes a steady-state visual evoked potential (SSVEP) and a movement-related cortical potential (MRCP) generated by the subject in response to the training content. When the SSVEP is detected, the training unit generates a training instruction to assist the subject in active training, thereby improving the accuracy of brain control.

IPC Classes  ?

• A61B 5/375 - Electroencephalography [EEG] using biofeedback
• A61B 5/374 - Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• A61B 5/378 - Visual stimuli
• G09B 19/00 - Teaching not covered by other main groups of this subclass

Abstract

An apparatus for turbulent flames, comprising an air tank (1), composite panels arranged inside the air tank and used to divide the interior space thereof, and baffles (8) used to close off air inlets between adjacent two composite panels. Each composite panel consists of dividing panels (2) and arced panels (3) fixedly connected to form an integral whole, and the sides of the dividing panels (2) away from the arced panels (3) are fixedly connected to inner walls of the air tank (1). The dividing panels (2) are slidably connected to the baffles (8). A top panel (4) and a bottom panel (5) are respectively fixedly connected to the top portion and the bottom portion of the air tank (1). The composite panels can be fixed inside the air tank (1). A rotating drum (6) is further movably connected to the interior of the air tank (1), and a movable hole (7) matched with the rotating drum (6) to allow the rotating drum (6) to penetrate therethrough into the air tank (1) is provided in the inside of the top panel (4). The rotating drum (6) and the bottom panel (5) are rotatingly connected. Through holes (9) matched with the baffles (8) to allow the baffles (8) to penetrate therethrough into the air tank (1) are provided in the inside of the top panel (4), and sliding grooves (10) matched with the baffles (8) are provided in the top portion of the bottom panel (5). Ventilation holes (11) are provided on all four sides of the bottom plate (5), a total of four ventilation holes (11) being provided, and each ventilation hole (11) being in communication with the interior of the air tank (1). By means of the present apparatus, turbulent flame testing can be performed, and the effect and impact of such fire extinguishing agents as inert gases and halogenated hydrocarbon gases on turbulent flames can be observed dynamically.

IPC Classes  ?

• G09B 25/00 - Models for purposes not provided for in group , e.g. full-sized devices for demonstration purposes
• G01N 31/12 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using combustion

Abstract

The disclosure relates to a synthesis method of long carbon chain semi-aromatic nylon. The synthesis method comprises the following steps: mixing a wet powdery nylon salt, an antioxidant, a catalyst, a surfactant and pellets, and carrying out a one-step solid state polymerization under dynamic mixing to obtain a powdery nylon; under dynamic mixing, enabling the pellets to promote the stirring and mixing of the material and reducing material adhesion to the wall; the one-step solid state polymerization comprises a pre-solid state polymerization and a post-solid state polymerization; in the pre-solid state polymerization, ensuring the nylon salt and the prepolymer not to be molten; in the post-solid state polymerization, gradually reducing the system pressure to vacuum, and keeping the system pressure in vacuum state for at least 1 hour; the temperature of the post-solid state polymerization is not lower than the termination temperature of the pre-solid state polymerization.

IPC Classes  ?

• C08G 69/30 - Solid state polycondensation
• C08G 69/06 - Solid state polycondensation
• C08G 69/26 - Polyamides derived from amino carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
• C08L 77/00 - Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers

Abstract

Provided is an anti-atopic dermatitis protein. A corresponding pharmaceutical composition contains a pharmaceutically acceptable carrier and the anti-atopic dermatitis protein. The anti-atopic dermatitis protein is one or more proteins selected from the group consisting of Helicobacter pylori-neutrophil-activating protein (HP-NAP) and recombinant maltose-binding protein fused to neutrophil-activating protein (rMBP-NAP). HP-NAP and rMBP-NAP can effectively treat AD in an oxazolone-induced AD model, providing brand-new drugs for the treatment of AD.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61P 17/04 - Antipruritics

Abstract

The invention discloses a bionic laminated thermal insulation material, which imitates a multi-thin laminated and thin-layer micro-pore structure of Sequoia sempervirens bark with fire resistance, corrosion resistance and excellent thermal insulation performance. A low thermal conductivity microporous powder is used as main raw material, while reinforcing agent, plasticizer and porosity agent are added to form microporous thin-layer units, and each thin-layer unit is bonded and laminated to make a laminated thermal insulation material. The thermal conductivity of the finished products is as low as 0.02˜0.05 W/m·k, with good thermal insulation and mechanical properties, which can be used in a temperature range below 1000° C., with better thermal insulation and energy-saving effect and toughness than ordinary thermal insulation materials, significantly reducing the thickness of the insulation layer, and can be widely used in industrial furnaces, thermal engineering devices, insulation pipes and other fields.

IPC Classes  ?

• B32B 7/027 - Thermal properties
• B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
• B32B 9/00 - Layered products essentially comprising a particular substance not covered by groups
• B32B 37/12 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by using adhesives
• B32B 38/00 - Ancillary operations in connection with laminating processes
• C04B 14/46 - Rock wool
• C04B 20/00 - Use of materials as fillers for mortars, concrete or artificial stone according to more than one of groups and characterised by shape or grain distribution; Treatment of materials according to more than one of the groups specially adapted to enhance their filling properties in mortars, concrete or artificial stone; Expanding or defibrillating materials
• C04B 24/02 - Alcohols; Phenols; Ethers
• C04B 24/04 - Carboxylic acids; Salts, anhydrides or esters thereof
• C04B 26/04 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C04B 38/00 - Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
• C04B 38/02 - Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by adding chemical blowing agents
• C04B 111/00 - Function, property or use of the mortars, concrete or artificial stone

Abstract

A preparation method for Retinal ganglion cells (RGCs), improving related methods for separating and purifying the RGCs. Multiple experiments verify that the number of RGCs obtained by a single Retinal tissue on average is obviously higher than that of the original "two-step immunopanning method", and the purity of the separated RGCs is also obviously higher than that of the "two-step immunopanning method". Different batches of RGCs are immunofluorescently stained randomly by respectively using specificity marking antibodies of β-tubulin III and BRN3A. The results show that the purities of the RGCs marked by the two antibodies have no statistical difference, thereby further verifying that the "improved two-step immunopanning method" can obtain primary RGCs having relatively stable purity and yield.

IPC Classes  ?

• C12N 5/079 - Neural cells

Abstract

Uses of 4-hydroxyisoleucine in preventing and/or treating a tumor. The uses comprise single-drug administration, combined use with a second active ingredient, or radiotherapy. Provided in the present invention is a novel tumor fighting method.

IPC Classes  ?

• A61K 31/198 - Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis

Abstract

1212(SBu t83424nn, which belongs to the tetragonal system; and the space group is I-42m. The compound has a strong yellow fluorescence under oxygen-free conditions, including two emission peaks at 456 nm and 556 nm, with a fluorescence lifetime of 0.37 ns and 3.12 ms, respectively; and the fluorescence at 556 nm is extremely sensitive to oxygen, and in an oxygen content range of 0-2.4 Pa, the fluorescence intensity quenching thereof and the oxygen pressure are in a good linear relationship, such that the oxygen can be quantitatively detected. The material has the advantages of a low detection limit, a fast response, a high sensitivity and a good stability, etc.

IPC Classes  ?

• C07F 1/10 - Silver compounds
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• G01N 21/64 - Fluorescence; Phosphorescence

Abstract

A function-recovering energy-dissipating reinforced concrete shear wall comprising a reinforced concrete shear wall body, common steel bars distributed in vertical direction within the reinforced concrete shear wall body, common steel bars distributed in horizontal direction within the reinforced concrete shear wall body, high-strength reinforcing materials arranged on left and right sides of the shear wall, and four dampers arranged in an X-shaped cross mode between a front reinforcement fabric and a rear reinforcement fabric that are formed by common steel bars distributed in vertical direction and common steel bars distributed in horizontal direction; a cylindrical piston rod having a hinge hole is arranged at the end portion of each damper.

IPC Classes  ?

• E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground
• E04B 1/98 - Protection against other undesired influences or dangers against mechanical destruction, e.g. by air-raids
• E04B 2/00 - Walls, e.g. partitions, for buildings; Wall construction with regard to insulation; Connections specially adapted to walls

Abstract

Provided is a method for preparing Ir@NBD-C, i.e. an efficient hydrogen evolution reaction (HER) catalyst. The method comprises: mixing a defective carbon substrate with deionized water until uniform; then adding iridium trichloride hydrate, melamine and boric acid, mixing same until uniform, and drying same to obtain a powder sample; and calcining same at 600±50ºC under an inert atmosphere for 1-2 h to obtain a hydrogen evolution reaction catalyst Ir@NBD-C-600. According to the efficient hydrogen evolution reaction catalyst material, by utilizing the bundling effect of nitrogen and boron on metal single atoms and metal clusters, the growth rate of particles is decreased, such that the diameter of noble metal nanoparticles is reduced to less than 2 nm, and uniform distribution is realized on a carbon substrate. The reduction in particle diameter makes the catalyst have a higher specific surface area, and also makes the catalyst expose more active surfaces, which is beneficial for catalysis. The overpotential of the catalyst under a certain current density during a HER process is thus significantly reduced; and the bundling effect of nitrogen and boron makes the metal nanoparticles maintain a good stability during the cycle.

IPC Classes  ?

• B01J 27/24 - Nitrogen compounds
• B01J 35/02 - Solids
• B01J 35/10 - Solids characterised by their surface properties or porosity
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water

Abstract

The present disclosure discloses a device and a method for continuously producing catalysts based on low-temperature coprecipitation. The device mainly includes: a metal salt preparation kettle, a primary reaction kettle, a secondary reaction kettle, a precipitant preparation kettle, a circulating refrigeration system, an automatic control system, a non-aqueous solvent storage tank and a water storage tank. Independent preparation kettles are provided for rapid dissolution of the raw materials, and can be used to prepare the raw materials for the next batch during the reactions that are carried out in the primary and secondary reaction kettles; the circulating refrigeration system refrigerates the primary and secondary reaction kettles, and thus during the reaction, the low-temperature precipitant makes it possible to offset the precipitation reaction heat and the heat caused by the stirring in the primary reaction kettle, and improve the refrigeration efficiency of the primary reaction kettle.

IPC Classes  ?

• B01J 4/02 - Feed devices; Feed or outlet control devices for feeding measured quantities of reagents
• B01J 4/04 - Feed devices; Feed or outlet control devices using osmotic pressure
• B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
• B01J 19/02 - Apparatus characterised by being constructed of material selected for its chemically-resistant properties
• B01J 19/18 - Stationary reactors having moving elements inside
• B01J 23/84 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
• B01J 35/08 - Spheres
• B01J 35/02 - Solids
• B01J 37/03 - Precipitation; Co-precipitation
• B01J 37/04 - Mixing
• B01J 37/10 - Heat treatment in the presence of water, e.g. steam
• F24H 4/04 - Storage heaters

Abstract

A method for segmentation of underground drainage pipeline defects based on full convolutional neural network includes steps of: collecting a data set of the underground drainage pipeline defects; processing the data set of the underground drainage pipeline defects; optimizing with a semantic segmentation algorithm; adjusting model hyperparameters; training a model; verifying the model; and testing the model. The method adopts a deep learning algorithm, optimizes the FCN full convolutional neural network, develops a semantic segmentation method suitable for complex and similar defect characteristics of underground drainage pipelines, and adopts real underground drainage pipeline defect detection big data, thereby realizing pixel-level segmentation of the underground drainage pipeline defects and providing better robustness and generality. The detection accuracy and efficiency of the underground drainage pipeline defects are effectively improved.

IPC Classes  ?

• G06K 9/62 - Methods or arrangements for recognition using electronic means
• G06N 3/08 - Learning methods

Abstract

A method for stabilizing and lifting a channel board by underwater grouting includes (A) when the channel board is damaged, removing the damaged channel board, cleaning and leveling a gravel layer under the damaged channel board, placing an undamaged channel board installed with first grouting pipes and a second grouting pipe on the gravel layer, wherein multiple geotextile bags are respectively bound to the first grouting pipes; when the channel board is subsided, installing first grouting pipes and a second grouting pipe into first grouting holes and a second grouting hole, respectively; (B) performing a first polymer grouting through the first grouting pipes, and performing a second polymer grouting through the second grouting pipe; (C) cutting off a part of the first grouting pipes the second grouting pipe which are exposed to the channel board, and leveling incisions; and (D) removing excess polymer left on the channel board.

IPC Classes  ?

• E02D 3/12 - Consolidating by placing solidifying or pore-filling substances in the soil
• E02B 5/02 - Making or lining canals

Abstract

th trough plate by the grouting machine; and repeating the steps (B) and (C) till the locked polymer anti-seepage wall is completed, wherein the steps (B) and (C) are repeated every time, N is automatically increased by 1.

IPC Classes  ?

• E02D 5/14 - Sealing joints between adjacent piles
• E02D 19/12 - Restraining of underground water by damming or interrupting the passage of underground water
• E02B 3/16 - Sealings or joints
• E02D 5/12 - Locking forms; Edge joints; Pile crossings; Branch pieces
• E02D 5/38 - Concrete or concrete-like piles cast in position making by use of mould-pipes or other moulds
• E02D 7/18 - Placing by vibrating
• E02D 31/02 - Protective arrangements for foundations or foundation structures; Ground foundation measures for protecting the soil or the subsoil water, e.g. preventing or counteracting oil pollution against ground humidity or ground water

Abstract

A method of preparing an indium oxide spherical powder with a controllable grain shape includes: (1) reacting a sulfuric acid solution, and then adding a nitric acid solution, to react with the metal indium to obtain a mixed solution system containing indium sulfate and indium nitrate; (2) adjusting a concentration of indium ions in the mixed solution system to between 0.45˜0.6M; (3) performing a precipitation reaction of the mixed solution with a precipitant, until a pH value of the solution is between 9˜10, and then having the solution precipitated and aged to obtain an indium hydroxide precursor slurry; (4) using a ceramic membrane to filter and wash the precursor slurry, and ending the washing to obtain a purified precursor sample; (5) drying the precursor sample at 80˜130° C.; and (6) ball-milling the precursor sample, and calcining the precursor at a calcination temperature to obtain the indium oxide powder.

IPC Classes  ?

• C01G 15/00 - Compounds of gallium, indium, or thallium

Abstract

2 powder with mass fraction of 10˜3 are ball-milled and mixed with deionized water, diluent, binder and polymer material by a sand mill to obtain an ITO ceramic slurry with a solid content between 70˜80% and a viscosity between 120˜300 mpa·s, with an average particle size D50 of the mixed powder controlled at 100˜300 nm; the ITO ceramic slurry is shaped by a pressure grouting to obtain an ITO ceramic green body with a relative density of 58˜62%; the ITO ceramic green body is put into a degreasing and sintering integrated furnace, and under a degreasing temperature of 700˜800° C., the ITO ceramic target is degreased in an atmospheric oxygen atmosphere for the time set to 12˜36 hours; the temperature increases from the degreasing temperature to the first sintering temperature of 1,600˜1,650° C.

IPC Classes  ?

• C23C 14/34 - Sputtering
• C04B 35/457 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zinc, tin or bismuth oxides or solid solutions thereof with other oxides, e.g. zincates, stannates or bismuthates based on tin oxides or stannates
• C04B 35/626 - Preparing or treating the powders individually or as batches
• C04B 35/638 - Removal thereof
• C04B 35/634 - Polymers
• C04B 35/636 - Polysaccharides or derivatives thereof
• C04B 35/64 - Burning or sintering processes
• C04B 111/00 - Function, property or use of the mortars, concrete or artificial stone

Abstract

Provided is a peptide having affinity to PD-1 or a modified peptide thereof. The modified peptide is an alanine scanning peptide, a point-mutated peptide or a truncated peptide. The peptide of the present invention can block interaction between PD-1/PD-L1 while having affinity to PD-1, and can be used for anti-tumor treatments, or treatment of other diseases.

IPC Classes  ?

• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61P 35/00 - Antineoplastic agents
• A61P 31/04 - Antibacterial agents
• A61P 31/12 - Antivirals
• A61P 31/10 - Antimycotics
• A61P 37/02 - Immunomodulators

Abstract

A magnetic moment correction method, comprising the following steps: S1, preparing magnetic particles without magnetic moment anisotropy; S2, uniformly dispersing the magnetic particles in a non-magnetic medium to prepare a correction sample mixture; S3, obtaining a magnetic moment value of unit weight of the correction sample mixture by means of measurement and calculation; S4, preparing a correction sample from the correction sample mixture, measuring the weight of the correction sample, and calculating a magnetic moment value of the correction sample; S5, correcting, by using the correction sample, a signal measured by a magnetic measurement device; and S6, measuring a signal value of an actual sample to be measured, and converting the signal value into a magnetic moment value of said actual sample by means of a correction result. According to the method, the magnetic particles without magnetic moment anisotropy are utilized and are mixed and sized with a sizing auxiliary material to prepare the correction sample having a same or similar shape and size as said actual sample, and the correction sample is utilized to correct the magnetic measurement device so that correction errors caused by different shapes, sizes and positions of said actual sample and the correction sample are avoided.

IPC Classes  ?

• G01R 35/00 - Testing or calibrating of apparatus covered by the other groups of this subclass
• G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
• G01R 33/12 - Measuring magnetic properties of articles or specimens of solids or fluids

Abstract

A method for carbothermic smelting of magnesium and co-production of calcium carbide, particularly appropriate for carbothermic smelting of magnesium using a mixture of magnesium oxide and calcium oxide as a raw material, and carbon as a reducing agent. Preparing a mixed powder containing magnesium oxide, calcium oxide and a carbon reducing agent; preparing the mixed powder into a pellet furnace charge, and placing same into a reactor provided with a heat source; configuring an absolute pressure P in the reactor to be in a range of 1000 Pa = P = atmospheric pressure, or to be micro-positive pressure, and a reaction temperature T being in a range of 11lg2P+71lgP+1210°C

IPC Classes  ?

• C22B 26/22 - Obtaining magnesium
• C01B 32/942 - Calcium carbide
• C01F 5/00 - Compounds of magnesium
• C21B 3/00 - General features in the manufacture of pig-iron
• C22B 5/10 - Dry processes by solid carbonaceous reducing agents
• C22B 13/00 - Obtaining lead
• C22B 19/00 - Obtaining zinc or zinc oxide
• C22B 23/00 - Obtaining nickel or cobalt
• C22B 25/00 - Obtaining tin
• C22B 26/20 - Obtaining alkaline earth metals or magnesium
• C22B 34/00 - Obtaining refractory metals
• C22B 47/00 - Obtaining manganese

Abstract

A method for carbothermic smelting of magnesium and co-production of calcium carbide, particularly appropriate for carbothermic smelting of magnesium using a mixture of magnesium oxide and calcium oxide as a raw material, and carbon as a reducing agent. Preparing a mixed powder containing magnesium oxide, calcium oxide and a carbon reducing agent; preparing the mixed powder into a pellet furnace charge, and placing same into a reactor provided with a heat source; configuring an absolute pressure P in the reactor to be in a range of 1000 Pa ≤ P ≤ atmospheric pressure, or to be micro-positive pressure, and a reaction temperature T being in a range of 11lg2P+71lgP+1210°C

IPC Classes  ?

• C22B 26/22 - Obtaining magnesium

Abstract

A displacement-current hybrid control quasi-static test loading system, which provides a loading system and method for a quasi-static test of a self-reset structure provided with a magnetorheological damper. The method comprises the following steps: S1. determining an active control parameter used for an actuator, the parameter comprising multiple stages of loading displacement angles, the quantity of cyclic loading cycles at each stage of loading displacement angles, and the period of each cyclic loading; S2. determining a semi-active control parameter used for a regulated direct current power supply, the parameter comprising the current level, the current application moment, the current duration, the change in current or termination moment, as well as the quantity of current levels of a magnetorheological damper; and S3. inputting the parameter determined in S1 into the actuator, and inputting the parameter determined in S2 into the regulated direct current power supply. In the described loading system, the rigidity, bearing capacity, and energy consumption performance of the self-reset structure can be increased by continuously applying a current. After a test, the current is cut off, thus eliminating the impact of the magnetorheological damper on the self-reset performance of the self-reset structure.

IPC Classes  ?

• G01N 3/02 - Investigating strength properties of solid materials by application of mechanical stress - Details
• G01M 13/00 - Testing of machine parts

Abstract

2COOH.

IPC Classes  ?

• C07D 407/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 307/58 - One oxygen atom, e.g. butenolide
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

The present invention relates to the technical field of sterilizing and disinfecting materials and specifically relates to an α-substituted phenyl structure-containing compound, a preparation method therefor, and a disinfectant. The α-substituted phenyl structure-containing compound provided in the present invention produces bactericidal effects by prompting the coagulation and denaturation of proteins of pathogenic microorganisms, specifically provides excellent sterilization and disinfection effects with respect to pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis var. niger spores, is noncorrosive with respect to metals, is free of pungent odors, has great aqueous solubility, is green and environmentally friendly, and is applicable as an active component of a disinfectant for wide application in different fields.

IPC Classes  ?

• C07C 235/34 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Abstract

The present invention provides an affinity peptide o f a PD-L1-IgV and an application thereof. The affinity peptide is selected from the polypeptide as represented by SEQ ID NO: 1, the same series of polypeptides and variants, which comprise: mutant peptides which are subjected to point mutation at position 4, position 5, position 10, and/or position 11 of the polypeptide as represented by SEQ ID NO: 4; and an N-terminal or C-terminal truncated peptide of the polypeptide as represented by SEQ ID NO: 8, or an alanine scanning peptide of the truncated peptide. The peptide obtained by screening and optimizing can block the interaction between PD-1 and PD-L1 well so as to treat tumor or other types of diseases.

IPC Classes  ?

• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61P 35/00 - Antineoplastic agents
• A61P 31/04 - Antibacterial agents

Abstract

The present application discloses a pipeline radar and television inspection robot which includes a robot body, a directional drilling lifting device, a directional drilling rotary device, a directional drilling swing device, a radar, cameras and a driving apparatus; wherein the directional drilling lifting device is on a front part of the robot body; the directional drilling rotary device is on the directional drilling lifting device; the directional drilling swing device is on the directional drilling rotary device; the radar and the cameras are on the directional drilling swing device; the driving apparatus are on a bottom of the robot body. The directional drilling lifting device, the radar and the cameras are plugged in the robot body. The robot body electrically connects to cables which electrically connect to a control system. The cameras and the radar are able to be adjusted and the components are connected as modules.

IPC Classes  ?

• F16L 55/40 - Constructional aspects of the body
• F16L 55/32 - Constructional aspects of the propulsion means, e.g. towed by cables being self-contained
• B25J 5/00 - Manipulators mounted on wheels or on carriages
• E21B 4/16 - Plural down-hole drives, e.g. for combined percussion and rotary drilling; Drives for multi-bit drilling units
• F17D 5/02 - Preventing, monitoring, or locating loss
• F17D 5/00 - Protection or supervision of installations
• F16L 101/30 - Inspecting, measuring or testing

Abstract

The present invention relates to a polymer expanding material in infiltration or seepage multi-water environment and a preparation method thereof, belonging to a technical field of polymer expanding foam materials. The polymer expanding material includes the following parts of materials by weight: 20-30 parts of rosin polyester polyol, 20-50 parts of isocyanate, 20-40 parts of PhireGuard® MB-512, 5-10 parts of HFO-1233zd, 1-2 parts of surfactant, 0.01-1 part of catalyst, and 0.01 parts of benzoyl chloride. The present invention has high sand fixing body strength, fast curing speed, good elastoplasticity, good pouring property and permeability, and good expanding property, which is suitable for infiltration or seepage multi-water environment, especially for dam infiltration, piping, and other problems during construction and subsequent operation of water conservancy projects.

IPC Classes  ?

• C08G 18/42 - Polycondensates having carboxylic or carbonic ester groups in the main chain
• C08G 18/76 - Polyisocyanates or polyisothiocyanates cyclic aromatic
• C08G 18/71 - Monoisocyanates or monoisothiocyanates
• C08K 5/1535 - Five-membered rings
• C08K 5/02 - Halogenated hydrocarbons
• C08G 18/20 - Heterocyclic amines; Salts thereof
• C08K 5/00 - Use of organic ingredients
• C08K 5/521 - Esters of phosphoric acids, e.g. of H3PO4
• C08K 5/07 - Aldehydes; Ketones
• E02B 3/16 - Sealings or joints
• C08G 101/00 - Manufacture of cellular products

Abstract

Provided is an anti-atopic dermatitis protein, and a corresponding pharmaceutical composition, containing a pharmaceutically acceptable carrier.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61K 47/42 - Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
• A61P 17/00 - Drugs for dermatological disorders
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• A61P 37/08 - Antiallergic agents
• A61P 17/04 - Antipruritics

Abstract

A method of treatment or prevention of fibrosis of human tissue or organ. The method includes administering a patient in need thereof a compound of formula (I).

IPC Classes  ?

• A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/443 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
• C07D 307/60 - Two oxygen atoms, e.g. succinic anhydride
• A61K 31/365 - Lactones
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

An energy-dissipating reinforced concrete shear wall having a recovery function and a construction method therefor. The energy-dissipating reinforced concrete shear wall having a recovery function comprises a reinforced concrete shear wall body (21), and common vertically distributed steel bars (23) and common horizontally distributed steel bars (24) disposed therein. High-strength steel bars (22) are vertically disposed on the left and right sides of the shear wall. Four dampers are provided between the front and rear rows of reinforcement nets formed by the common vertically distributed steel bars (23) and the common horizontally distributed steel bars (24) in an X-shaped crossing mode. Cylindrical piston rods (31) having hinge holes at the ends of the four dampers are connected to diamond steel plate connecting rods (2) by means of movable hinges (1). The diamond steel plate connecting rods (2) are disposed in diamond connecting rod protective housings (4) with grooves (3) formed. The diamond connecting rod protective housings (4) are connected to connecting flanges (34) of the dampers. One ends of steel strands (5) are connected to the cylindrical piston rods (33), metal corrugated pipes (6) are disposed on the outer sides of the steel strands (5) and cylindrical piston rods (33), and the other ends of the steel strands (5) are anchored on the reinforced concrete shear wall by means of anchors (7). The shear wall has a recovery function, and also has high energy-dissipating capacity.

IPC Classes  ?

• E04B 2/00 - Walls, e.g. partitions, for buildings; Wall construction with regard to insulation; Connections specially adapted to walls
• E04B 1/98 - Protection against other undesired influences or dangers against mechanical destruction, e.g. by air-raids
• E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground

Abstract

The present invention belongs to the technical field of medicine, and discloses use of 14-deoxy-11,12-dehydro-8,12-epoxy-andrographolide and derivatives thereof and 14-deoxy-11,12-dehydro-7,8-ene andrographolide and 15-substituted derivatives thereof in the preparation of medicaments for preventing and treating diseases having fibrotic pathological processes. It has been proved by experiments that such compounds significantly inhibit the migration and activation of hepatic stellate cells, significantly inhibit TGF-β1-induced mesenchymal transition in human alveolar type II epithelial cells A549; significantly inhibit TGF-β1-induced mesenchymal transition in epithelial cells HK-2 in human renal cortex proximal convoluted tubules; and inhibit angiotensin II (AngII)-induced migration of primary human cardiac fibroblasts HCFB. In a mouse common bile duct ligation model, a silica-induced mouse pulmonary fibrosis model and a mouse unilateral ureteral ligation model, the compounds in this study all exhibit good anti-fibrotic activities in vivo. Such compounds are used as active ingredients in the preparation of anti-fibrotic medicaments, and have high efficiency and low toxicity, thus having good prospects for being developed into medicaments resistant to multiple fibrosis.

IPC Classes  ?

• C07D 407/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 307/58 - One oxygen atom, e.g. butenolide
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

A technical innovation method based on innovation dimensions and innovation rules, comprising: constructing at least one first category of innovation dimensions; analyzing and identifying a second potential category of innovation dimensions; summarizing and sorting the first category of innovation dimensions and the second category of innovation dimensions, so as to form innovation dimensions; forming at least one first category of innovation rules; analyzing and identifying a second potential category of innovation rules summarizing and sorting the first innovation rules and the second innovation rules, so as to form innovation rules; transforming and recombining the innovation dimensions and innovation rules to construct a new technical innovation solution; and analyzing and evaluating the new technical innovation solution. The method is easy to learn, use and remember, not only conforming to the customary thinking habits of Chinese people and providing a new technical innovation method for a person skilled in the art, but the technical solution obtained by the method is also well combined with the specific technology under study, and the formed technical solution is practically applicable.

IPC Classes  ?

• G06F 17/30 - Information retrieval; Database structures therefor

Abstract

3, and 0-0.05 mmol/L of a magnesium ion complexing agent; employing the substrate material as a cathode, a graphite flake as an anode, heating the electrolyte to a temperature of between 60 and 90° C., and synchronously immersing the cathode and the anode into the electrolyte; and implementing an electrochemical deposition method in the electrolyte for between 20 and 60 min.

IPC Classes  ?

• C25D 3/56 - Electroplating; Baths therefor from solutions of alloys
• C25D 11/36 - Phosphatising
• C25D 9/12 - Electrolytic coating other than with metals with inorganic materials by cathodic processes on light metals
• A61L 27/04 - Metals or alloys
• C25D 5/42 - Pretreatment of metallic surfaces to be electroplated of light metals
• C25D 5/18 - Electroplating using modulated, pulsed or reversing current
• C25D 3/22 - Electroplating; Baths therefor from solutions of zinc
• A61L 27/32 - Phosphorus-containing materials, e.g. apatite
• A61L 27/58 - Materials at least partially resorbable by the body

Abstract

The present invention relates to the technical field of medicine, and relates to a 15-idene-14-deoxy-11,12-dehydroandrographolide derivative and a use thereof in anti-fibrosis. Experiments show that this compound can significantly inhibit metastasis and activation of hepatic stellate cells LX-2, significantly reduce the fibrosis level of hepatic tissues of rats infected with hepatic fibrosis, reduce contents of extracellular matrix protein (ECM) related components, effectively inhibit immune inflammation, inhibit activation of hepatic stellate cells in hepatic tissues, promote collagen degradation, significantly inhibit TGF-β1-induced epithelial-mesenchymal transition (EMT) of human alveolar type II cells A549 and kidney epithelial cells HK-2, significantly reduce the bleomycin-induced pulmonary fibrosis degree in mice and the unilateral ureteral obstruction-induced renal fibrosis degree in rats, and significantly inhibit angiotensin II (Ang II)-induced proliferation of human cardiac fibroblasts (HCFB). This compound can be used as an active ingredient for preparing anti-fibrosis drugs, which are efficient and have low toxicity, thus providing a novel medicine route for treatment and prevention of diseases related with fibrosis, and expanding the optional range of clinical medication. The compound has good application and development prospects.

IPC Classes  ?

• C07D 307/60 - Two oxygen atoms, e.g. succinic anhydride
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/365 - Lactones
• A61K 31/443 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

An adhesive composition includes an epoxy component and an additive component reactive with the epoxy component. The additive component includes an imidazole present in an amount of less than or equal to 10 parts by weight based on 100 parts by weight of the adhesive composition, and an amine present in an amount of less than or equal to 5 parts by weight based on 100 parts by weight of the adhesive composition. The epoxy component and the additive component are present in the adhesive composition in a ratio of from 1: 1 to 15: 1. A method of forming a component includes curing the adhesive composition at a temperature of less than or equal to 150 ℃ for less than or equal to 30 minutes to thereby join the first substrate and the second substrate.

IPC Classes  ?

• B32B 27/38 - Layered products essentially comprising synthetic resin comprising epoxy resins
• B32B 27/26 - Layered products essentially comprising synthetic resin characterised by the use of special additives using curing agents
• C09J 163/00 - Adhesives based on epoxy resins; Adhesives based on derivatives of epoxy resins

Abstract

Disclosed is an application of sodium 5-bromo-2-(α-hydroxypentyl) benzoate (BZP) in drugs treating cardiovascular disease, belonging to the field of pharmaceutical chemistry. Experiments show that BZP has a protective effect with regard to acute and chronic myocardial ischaemia-reperfusion injury in mice, BZP oral administration and intravenous injection reduce animal overall acute myocardial infarction areas, and BZP reduces isolated perfused heart acute ischaemia-reperfusion injury myocardial infarction areas in mice, thereby improving myocardial contractile function and reducing haematological myocardial injury markers. In addition, BZP chronic oral administration delays the progress of cardiac hypertrophy changing to heart failure after acute myocardial infarction in mice, reduces ventricular remodelling caused by ischaemic heart disease in mice, and significantly improves heart function treatment effects. Furthermore, BZP temporarily reduces the blood pressure of hypertensive rats (SHR rats). These effects show that BZP has effective clinical research and development prospects for drugs protecting against acute and chronic myocardial infarction myocardial injury.

IPC Classes  ?

• C07C 65/03 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
• C07C 51/09 - Preparation of carboxylic acids or their salts, halides, or anhydrides from carboxylic acid esters or lactones
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61P 9/00 - Drugs for disorders of the cardiovascular system

Abstract

Provided are a coating capable of improving the surface corrosion resistance and biocompatibility of medical magnesium and magnesium alloys and a preparation method therefor. In the present invention, an electrolyte is composed of an aqueous solution containing a Zn2+ salt, a Ca2+ salt, a H2PO4- salt and NaNO3. A zinc-calcium-phosphate-containing coating with good coverage is prepared on the surfaces of magnesium and a magnesium alloy with the electrolyte through an electrochemical deposition method. The coating of the present invention falls within non-stoichiometric CaZn2(PO4)2·2H2O coatings, and is mainly applied to medical magnesium and magnesium alloys, especially for the surface treatment of a magnesium alloy for bone implant materials. The significant advantages thereof are that degradation can be achieved while the corrosion resistance of a magnesium matrix is improved, and the presence of the coating does not change the degradability of the matrix. At the same time, Zn2+ can be released during the degradation of the coating, the differentiation of osteoblasts can be promoted, and the activity of osteoclasts can be inhibited, such that the biocompatibility of the matrix is also improved. Thus, the coating has good application prospect in magnesium alloy bone implant medical instruments.

IPC Classes  ?

• C25D 9/12 - Electrolytic coating other than with metals with inorganic materials by cathodic processes on light metals

Abstract

Provided are a modified interleukin 12 (nsIL-12) and a gene, a recombinant vector and a use thereof in preparing drugs for treating tumours.

IPC Classes  ?

• C12N 15/24 - Interleukins
• C12N 15/861 - Adenoviral vectors
• C12N 15/863 - Poxviral vectors, e.g. vaccinia virus
• C12N 15/869 - Herpesviral vectors
• C07K 14/54 - Interleukins (IL)
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 38/20 - Interleukins
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage.

IPC Classes  ?

• A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
• A61K 31/365 - Lactones
• A61K 31/443 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C07D 307/33 - Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
• C07D 307/58 - One oxygen atom, e.g. butenolide
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/455 - Nicotinic acid, i.e. niacin; Derivatives thereof, e.g. esters, amides
• A61K 47/38 - Cellulose; Derivatives thereof

Abstract

A dual-power photovoltaic inverter formed by a preceding-stage conversion circuit and a subsequent-stage inverter circuit; the subsequent-stage inverter circuit is a three-phase inverter circuit; the preceding-stage conversion circuit supplies power for the subsequent-stage inverter circuit via a positive power supply wire (P) and a negative power supply wire (N); the preceding-stage conversion circuit consists of at least one dual-power conversion unit; and the dual-power conversion unit consists of a first capacitor (C1), a second capacitor (C2), clamping capacitors (C3, C4, C5, C6), a first converter (Cv1) and a second converter (Cv2). The dual-power conversion unit in the preceding-stage conversion circuit reduces costs and improves efficiency.

IPC Classes  ?

• H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers
• H02M 7/537 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters

Abstract

Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage.

IPC Classes  ?

• C07D 405/00 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/365 - Lactones
• A61K 31/443 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C07D 307/33 - Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
• C07D 307/58 - One oxygen atom, e.g. butenolide
• A61K 47/38 - Cellulose; Derivatives thereof

Abstract

Disclosed are a vaccine comprising an adenovirus vector and a vaccinia virus vector and an application of the vaccine in treating tumor. The vaccine comprises oncolytic adenovirus and vaccinia virus; the two viruses are used in sequence, wherein the oncolytic adenovirus is the reproductive human adenovirus type 5 and the vaccinia virus is the vaccinia virus for smallpox vaccine.

IPC Classes  ?

• A61K 39/235 - Adenoviridae
• A61K 39/275 - Poxviridae, e.g. avipoxvirus
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to the field of pharmacochemistry. Disclosed are fluorinated and azido-substituted pyrimidine nucleoside derivatives, particularly compounds of the formula shown below: Also disclosed are methods of preparation and uses for these compounds. The compounds can be used for preparing medicaments for treating diseases such as tumors and viral infections, and can be used separately or in combination with other medicaments. The compounds also have effective activity against diseases such as tumors and viral infections, while having few side effects, and thus have potential application value.

IPC Classes  ?

• C07H 19/00 - Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
• C07H 19/06 - Pyrimidine radicals
• C07H 19/14 - Pyrrolo-pyrimidine radicals

Abstract

Andrographis paniculata.

IPC Classes  ?

• A61K 31/365 - Lactones
• C07D 307/33 - Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
• A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca