The present disclosure relates to polymers and additives that may be used in energy storage applications, and, more specifically, in liquid and solid state electrolytes. The present disclosure further relates to batteries and capacitors containing the electrolytes.
The present disclosure describes methods of polyimide synthesis and polyimides made therefore. The method includes placing a tetracarboxylic compound and a solvent in a reaction vessel and adding a first amount of a diamine. The first amount of the diamine is not more than 99.5 mol % of the tetracarboxylic compound inside the reaction vessel. The method can include agitating the mixture and determining a viscosity of the mixture. The method can further include adding a second amount of the diamine. The last steps can be repeated until the viscosity increases to a target value. The target viscosity can be correlated to a peak weight-averaged molecular weight of the polyimide.
A polyimide material is obtained from a first monomer and a second monomer. The first monomer includes an es-ter-containing dianhydride. The second monomer includes a diamine. The polyimide material has desirable optical, structural, thermal, mechanical properties, or combination thereof.
The present disclosure describes the engineering of microbial cells for fermentative production of deoxyhydrochorismic acid and provides novel engineered microbial cells and cultures, as well as related deoxyhydrochorismic acid production methods.
A polyamide-imide material comprises an amidophenyl-ethyl-imide moiety or alternatively an imidophenyl-ethyl-amide moiety as depicted in formulas (I) or (II) in the disclosure. The polyamide-imide material can have selected mechanical properties, such as a tensile modulus between at least 3.5 GPa and at least 7.8 GPa, a glass transition temperature between at least 180° C. and at least 305° C., an elongation at break of a film of the polyamide-imide material having a thickness of 25 micrometer (±5 micrometer) of not more than 15%, or a folding endurance of the film over a pin having a radius of 1 mm between at least 10,000 folds and at least 1,000,000 folds. The polyamide-imide film can have high transparency of visible light, a low yellow index, and a low haze.
The present disclosure provides compounds of Formula (I):
The present disclosure provides compounds of Formula (I):
The present disclosure provides compounds of Formula (I):
or a pharmaceutically acceptable salt, solvate, or tautomer thereof, and uses of the same in treating a disease or disorder (e.g., cancer or fibrosis).
C07K 11/02 - Depsipeptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof cyclic, e.g. valinomycins
C07K 14/36 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from ActinomycesPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Streptomyces (G)
C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
C12N 15/52 - Genes encoding for enzymes or proenzymes
C12N 15/76 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for ActinomycesVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Streptomyces
C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
7.
Engineered Biosynthetic Pathways for Production of Histamine by Fermentation
The present disclosure describes the engineering of microbial cells for fermentative production of histamine and provides novel engineered microbial cells and cultures, as well as related histamine production methods.
C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium
C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
Provided are bio-based compositions of biopolymers connected by binding domains coupled to polypeptide tethers. Biopolymers so connected exhibit enhanced physical properties.
The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof. NADPH availability is altered by one or more of: expressing an altered GAPDH, expressing a variant glutamate dehydrogenase (gdh), aspartate semialdehyde dehydrogenase (asd), dihydropicolinate reductase (dapB), and meso-diaminopimelate dehydrogenase (ddh), expressing a novel nicotinamide nucleotide transhydrogenase, expressing a novel threonine aldolase, and expressing or modulating the expression of a pyruvate carboxylase in the host cells.
An adhesive material includes a polymeric-based adhesive composition and a bio-based reactive diluent, wherein the bio-based reactive diluent includes a hydrocarbon ring structure having at least one pendant epoxy end group or a hydrocarbon non-ring structure having at least two pendant epoxy end groups.
An adhesive material includes a polymeric-based adhesive composition and a bio-based small molecule, wherein the bio-based small molecule has a degradation temperature of at least 100°C.
The present invention relates to a polyimide film that comprises a polyimide resin, that has a tensile elastic modulus of greater than 7.6 GPa, that has a total light transmittance of 85% or more, and that has a yellowness of not more than 7.0.
C08L 79/04 - Polycondensates having nitrogen-containing heterocyclic rings in the main chainPolyhydrazidesPolyamide acids or similar polyimide precursors
14.
METHODS TO IDENTIFY NOVEL INSECTICIDAL PROTEINS FROM COMPLEX METAGENOMIC MICROBIAL SAMPLES
The present disclosure provides methods and systems for identifying insecticidal protein-encoding GIs (GIs). The present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to GI search bioinformatic tools and techniques.
The present disclosure describes the engineering of microbial cells for fermentative production of ectoine and provides novel engineered microbial cells and cultures, as well as related ectoine production methods.
This asymmetric diamine-containing agent is represented by formula (I) [in the formula, RI-RVI22 absorber, a dispersant, a releasing agent, a pH adjuster, a cleaning agent, a softening agent, an anticorrosive, a coating formulation, an emulsifier, a herbicide, a fuel additive, a grinding aid, a surfactant, a thickener, a thinner, a swelling agent, a water absorbent, a gelling agent, a binder, a film-forming agent, a flocculant, an adhesive, a surface modifier, a sustained-release agent, a vulcanization accelerator, a linker agent for DNA labeling, a synthetic agent for a pharmaceutical intermediate, and a synthetic agent for a catalyst.
C08G 69/26 - Polyamides derived from amino carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
The present disclosure describes the engineering of microbial cells for fermentative production of 4-APEA and related products and provides novel engineered microbial cells and cultures, as well as related 4-APEA production methods.
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
The present disclosure provides compositions and methods for detection of ectopic integration of a DNA fragment. The disclosure further provides a method for determining the quality of a genomic transformation.
A polyamideimide includes at least one moiety of an extended diamine structure. The polyamideimide has desirable optical, structural, thermal, mechanical properties, or combination thereof.
The present disclosure provides methods for producing gene-edited cells free of gene-editing system molecules through the manipulation of prototrophy. Exemplary system molecules include those required for CRISPR editing techniques, such as plasmids and genes encoding Cas nucleases. The methods may employ constructs that temporarily disrupt prototrophy, the removal of which restores prototrophy. Also disclosed are gene-edited cells and populations of gene-edited cells comprising these constructs. The present methods and compositions may be used to achieve desired gene editing of a host cell in the absence of extraneous genetic material remaining from the genetic engineering technique itself.
The present disclosure provides epoxy adhesive compositions with increased adhesion to surfaces, including metal surfaces, comprising a catechol modifier and methods of use thereof.
A polyamide-imide includes at least one moiety of an extended dianhydride structure. The polyamideimide has desirable optical, structural, thermal, mechanical properties, or combination thereof.
C08G 73/06 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromoleculePolyhydrazidesPolyamide acids or similar polyimide precursors
The present invention relates to an optical film comprising a polyimide-based resin having a constitutional unit derived from an aliphatic diamine, wherein the optical film has a glass transition temperature of 165° C. or higher and an optical transmittance at 350 nm of 10% or less.
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
25.
A MODULAR AND POOLED APPROACH FOR MULTIPLEXED CRISPR GENOME EDITING
Provided herein are nucleic acid constructs comprising multiple guide RNAs interspersed with tRNA sequence at regular intervals as well as expression vectors and compositions comprising the same. Also provided herein are methods for assembling the nucleic acid constructs comprising multiple guide RNAs interspersed with tRNA sequence at regular intervals in a pooled and/or modular manner. Methods for using the nucleic acid constructs comprising multiple guide RNAs interspersed with tRNA sequence at regular intervals to facilitate multiplexed genomic editing of a host cell comprising said nucleic acid constructs are also provided herein.
The present invention relates to a method for producing an optical film, the method comprising: step (I) for dissolving a polyimide-based resin in a solvent to prepare a varnish; step (II) for applying the varnish onto a substrate to form a coating film; and step (III) for drying the coating film to form a film, wherein the polyimide-based resin contains a constitutional unit derived from an aliphatic diamine, the solvent in step (I) has a moisture absorption speed per unit area of 25% by mass/h m2 or more as measured by a Karl Fischer method, and a time T from the completion of the formation of the coating film in step (II) to the start of the drying of the coating film in step (III) satisfies the following equation (A):
The present invention relates to a method for producing an optical film, the method comprising: step (I) for dissolving a polyimide-based resin in a solvent to prepare a varnish; step (II) for applying the varnish onto a substrate to form a coating film; and step (III) for drying the coating film to form a film, wherein the polyimide-based resin contains a constitutional unit derived from an aliphatic diamine, the solvent in step (I) has a moisture absorption speed per unit area of 25% by mass/h m2 or more as measured by a Karl Fischer method, and a time T from the completion of the formation of the coating film in step (II) to the start of the drying of the coating film in step (III) satisfies the following equation (A):
T
<
0.0018
Vs
(
A
)
The present invention relates to a method for producing an optical film, the method comprising: step (I) for dissolving a polyimide-based resin in a solvent to prepare a varnish; step (II) for applying the varnish onto a substrate to form a coating film; and step (III) for drying the coating film to form a film, wherein the polyimide-based resin contains a constitutional unit derived from an aliphatic diamine, the solvent in step (I) has a moisture absorption speed per unit area of 25% by mass/h m2 or more as measured by a Karl Fischer method, and a time T from the completion of the formation of the coating film in step (II) to the start of the drying of the coating film in step (III) satisfies the following equation (A):
T
<
0.0018
Vs
(
A
)
wherein Vs represents a moisture absorption speed per minute (% by mass/min) of the solvent as determined by a Karl Fischer method.
C09D 179/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
The present invention relates to an optical film having a glass transition temperature of 165° C. or higher, an optical transmittance at 350 nm of 10% or less, an in-plane retardation of 30 nm or less, and a retardation in a thickness direction of 100 nm or less.
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
The present invention relates to a method for producing a long optical film, the method comprising a step for preparing a varnish by dissolving a polyimide-based resin in a solvent, wherein the polyimide-based resin contains a constitutional unit derived from an aliphatic diamine, and a moisture absorption speed per unit area of the solvent is 25% by mass/h·m2 or less as determined by a Karl Fischer method.
The present disclosure relates to compositions derived from bioreachable molecules, such as amino acids or hydroxy acids. In particular, the composition can be a monomer, a polymer, or a copolymer derived from an amino acid dimer or a hydroxy acid dimer.
C07D 241/08 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
The present disclosure relates to compositions derived from bioreachable molecules, such as amino acids and/or steroids. In particular, the composition can be a monomer, a polymer, or a copolymer derived from an amino acid dimer. Such compositions can optionally include a functionalized steroid.
C07D 241/08 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
Presented herein is a high-throughput (HTP) genomic engineering platform for improving the production of therapeutic proteins in Chinese hamster ovary (CHO) cells. The disclosed HTP genomic engineering platform is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. The platform utilizes a unique suite of HTP genetic engineering tools to explore the genomic landscape associated with therapeutic protein production pathways, in order to unravel the biological drivers and disentangle the uncharacterized genetic architecture responsible for optimizing therapeutic protein production in CHO cells.
The present disclosure provides compositions and methods for gene editing. The disclosure also provides methods for removing extra-chromosomally replicating plasmids from competent cells.
A process for the production of dihydronepetalactone including hydrogenating nepetalactone in the presence of a catalytic metal is provided. The catalytic metal may include nickel. The process may be performed in an aqueous medium.
The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs). In some embodiments, the present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to MGC search bionformatic tools and techniques.
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
The present disclosure describes the engineering of microbial cells for fermentative production of 3,4-dihydroxybenzoic acid and provides novel engineered microbial cells and cultures, as well as related 3,4-dihydroxybenzoic acid production methods.
The present invention pertains to a method for producing a polyimide-based resin, the method comprising a step for reacting a 4,4'-(hexafluoroisopropylidene)diphthalic dianhydride (6FDA) raw material with an aliphatic diamine, wherein the charged amount of the 6FDA raw material in the step is calculated on the basis of the total peak area of an impurities-derived peak area and a 6FDA-derived peak area, which is detected when the 6FDA raw material is measured by liquid chromatography.
The present invention relates to a film which comprises a polyimide-based resin having a structural unit derived from an aliphatic diamine and a fluorine atom, wherein the content of an oligomer having a molecular weight of at most 10,000 is 6.1 mass% or less with respect to the mass of the film.
A microorganism engineering project employs a vector representation of a biological network. The vector representation allows researchers to input elements known to have a direct impact on a goal of the project (e.g., an element in the metabolic pathway for generating a compound of interest). Within the vector representation, other biological elements are positioned with respect to an input element based on biological relatedness. In this manner, based on positions within the vector representation, candidate elements may be identified for editing. For example, if the elements are associated with a gene, the gene sequence may be knocked out and/or a different promoter may be used for regulating the gene.
The present disclosure relates to compositions and methods of generating circular-permuted nucleic acids for direct use in homology directed genome editing. The method also allows the joining of a large number of DNA fragments, in a deterministic fashion. It can be used to rapidly generate nucleic acid libraries that can be directly used in a variety of applications without further cloning steps that include, for example, genome editing and pathway assembly. Kits for performing the method are also disclosed.
The present disclosure describes the engineering of microbial cells to express a heterologous L-tyrosine ammonia lyase for fermentative production of p-coumaric acid. Additional genetic alterations were introduced to improve p-coumaric acid titer. The disclosure further describes novel engineered microbial cells and cultures, as well as related p-coumaric acid production methods.
The present disclosure provides methods for predicting phenotypic performance of a host cell in industrial culture. Specifically, the present disclosure provides methods for predicting phenotypic performance of a host cell in industrial culture by determining the metabolite fingerprinting profile of a host cell in small lab-scale culture and applying said profile to a predictive model of phenotypic performance.
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
A CRISPR system is successfully used to modify the genomes of a gram-positive bacterium, such as a species of the Cornybacterium genus. Methods for modifying Corynebacterium species include single-nucleotide changes, creating gene deletions and/or insertions.
C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium
46.
SELECTING BIOLOGICAL SEQUENCES FOR SCREENING TO IDENTIFY SEQUENCES THAT PERFORM A DESIRED FUNCTION
Systems, methods, and non-transitory computer-readable media are described for identifying candidate biological sequences for screening to determine whether the candidate biological sequences enable a biological function. Identification may be based upon (a) degrees of similarity between test sequences and reference sequences that are known to enable the function, and (b) comparisons of regions in the test sequences to reference regions that are known to bind to a molecule. Identification may also be based upon determining sequence similarities between reference sequences, grouping the reference sequences into clusters that each correspond to a molecule that is indicated as capable of being bound by a reference sequence in the cluster, and identifying matching test sequences based upon a comparison of the test sequences with reference sequences in the clusters.
A method for automated, high throughput cellular library generation is disclosed. The method includes providing a suspension including transformed cells and plating the transformed cells onto solid surfaces of each of at least one reservoir of a reservoir plate. The solid surfaces can include a liquid growth medium. The reservoir plate is incubated, and after cellular growth has occurred on at least one plated surface of the reservoir plate, a series of automatic steps are performed. The automatically-performed steps include adding disaggregation solution to the reservoir plate, applying a mechanical force, such as a rotational force, to the reservoir plate to produce resuspended cells, and/or collecting the resuspended cells.
In one embodiment, a filament can comprise a thermoplastic polyimide, wherein the filament is adapted for use in a fused filament fabrication process and the thermoplastic polyimide may have a glass transition temperature not greater than 215° C. Three-dimensional bodies can be printed with the filament, wherein the three-dimensional bodies can have high strength values with even mechanical properties in printing direction and orthogonal to the printing direction.
The present disclosure relates to polymers and additives that may be used in energy storage applications, and, more specifically, in liquid and solid state electrolytes. The present disclosure further relates to batteries and capacitors containing the electrolytes.
G06F 30/18 - Network design, e.g. design based on topological or interconnect aspects of utility systems, piping, heating ventilation air conditioning [HVAC] or cabling
50.
FILAMENT COMPRISING A THERMOPLASTIC POLYIMIDE AND THREE-DIMENSIONAL BODY MADE FROM THE FILAMENT
In one embodiment, a filament can comprise a thermoplastic polyimide, wherein the filament is adapted for use in a fused filament fabrication process and the thermoplastic polyimide may have a glass transition temperature not greater than 215°C. Three-dimensional bodies can be printed with the filament, wherein the three-dimensional bodies can have high strength values with even mechanical properties in printing direction and orthogonal to the printing direction.
A polyimide material is obtained from a first monomer and a second monomer. The first monomer includes an ester-containing dianhydride. The second monomer includes a diamine. The polyimide material has desirable optical, structural, thermal, mechanical properties, or combination thereof.
The present disclosure describes the engineering of microbial cells for fermentative production of deoxyhydrochorismic acid and provides novel engineered microbial cells and cultures, as well as related deoxyhydrochorismic acid production methods.
The disclosure relates to the biosynthesis of terpenoids, such as, for example, geraniol and derivatives thereof, using genetic engineering. In particular, the disclosure relates to the biosynthesis of nepetalactol, nepetalactone, dihydronepetalactone, and derivatives thereof. The disclosure provides recombinant cells genetically engineered to produce high levels of nepetalactol, nepetalactone and/or dihydronepetalactone. The disclosure also provides methods of producing nepetalactol, nepetalactone and dihydronepetalactone using cell-based systems as well as cell-free systems.
Systems, methods and computer-readable media are provided for designing experiments for organisms at a first scale to generate first-scale performance data used in predicting performance of the organisms at a second, larger scale. The design includes determining first-scale screening conditions based at least in part upon the contribution of second-scale conditions to performance parameters of an organism at the second scale. The first-scale screening conditions include one or more proxies for second-scale conditions that cannot be replicated at first scale. The design determines first-scale screening parameters based at least in part upon computer modeling of the metabolism of the organism at the second scale.
C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
G06Q 10/06 - Resources, workflows, human or project managementEnterprise or organisation planningEnterprise or organisation modelling
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
Provided are native promoters comprising polynucleotides isolated from Corynebacterium glutamicum, and mutant promoters derived therefrom, which may be used to regulate, i.e., either increase or decrease, gene expression. Also provided are promoter ladders comprising a plurality of the promoters having incrementally increasing promoter activity. Also provided are host cells and recombinant vectors comprising the promoters, and methods of expressing genes of interest and producing biomolecules using the host cells.
C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
The present disclosure describes the engineering of microbial cells for fermentative production of cystathionine and provides novel engineered microbial cells and cultures, as well as related cystathionine production methods. An engineered microbial cell that expresses a heterologous cystathionine beta-synthase or a heterologous cystathionine gamma-synthase, wherein the engineered microbial cell produces cystathionine.
C12N 15/75 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium
C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
In one embodiment, a powder composition can comprise polyimide particles, wherein the polyimide particles can have a glass transition temperature of not greater than 200° C. and a crystallinity of not greater than 20%. The powder composition can be adapted for forming a three-dimensional polyimide-based body in a powder-based additive manufacturing process. In one aspect, the polyimide particles can have an average particle size (D50) of at least 20 microns and not greater than 120 microns, an amount of the polyimide particles can be at least 60 wt % based on the total weight of the powder composition; and a material of the polyimide particles is a polymerization product of at least one diamine monomer and at least one dianhydride monomer.
C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
B29C 64/153 - Processes of additive manufacturing using only solid materials using layers of powder being selectively joined, e.g. by selective laser sintering or melting
58.
POWDER COMPOSITION COMPRISING POLYIMIDE PARTICLES, THREE-DIMENSIONAL POLYIMDE-BASED BODY, AND METHOD OF FORMING THE BODY
In one embodiment, a powder composition can comprise polyimide particles, wherein the polyimide particles can have a glass transition temperature of not greater than 200°C and a crystallinity of not greater than 20%. The powder composition can be adapted for forming a three-dimensional polyimide-based body in a powder-based additive manufacturing process. In one aspect, the polyimide particles can have an average particle size (D50) of at least 20 microns and not greater than 120 microns, an amount of the polyimide particles can be at least 60 wt% based on the total weight of the powder composition; and a material of the polyimide particles is a polymerization product of at least one diamine monomer and at least one dianhydride monomer.
C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
C08L 79/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
B29C 64/153 - Processes of additive manufacturing using only solid materials using layers of powder being selectively joined, e.g. by selective laser sintering or melting
A polyamide-imide material comprises an amidophenyl-ethyl-imide moiety or alternatively an imidophenyl-ethyl-amide moiety as depicted in formulas (I) or (II) in the disclosure. The polyamide-imide material can have selected mechanical properties, such as a tensile modulus between at least 3.5 GPa and at least 7.8 GPa, a glass transition temperature between at least 180°C and at least 305°C, an elongation at break of a film of the polyamideimide material having a thickness of 25 micrometer (± 5 micrometer) of not more than 15 %, or a folding endurance of the film over a pin having a radius of 1 mm between at least 10,000 folds and at least 1,000,000 folds. The polyamide-imide film can have high transparency of visible light, a low yellow index, and a low haze.
C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
B01D 71/64 - PolyimidesPolyamide-imidesPolyester-imidesPolyamide acids or similar polyimide precursors
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
The present disclosure describes the engineering of microbial cells for fermentative production of 3-amino-4-hydroxybenzoic acid and provides novel engineered microbial cells and cultures, as well as related 3-amino-4-hydroxybenzoic acid production methods. Embodiments 1: An engineered microbial cell that produces 3-amino-4-hydroxybenzoic acid, wherein the engineered microbial cell expresses: (a) a non-native 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy) heptanoate synthase; and (b) a non-native 3-amino-4-benzoic acid synthase.
C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium
C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alga, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium
C12N 15/80 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
The present disclosure describes the engineering of microbial cells for fermentative production of 3,4-dihydroxybenzoic acid and provides novel engineered microbial cells and cultures, as well as related 3,4-dihydroxybenzoic acid production methods.
The present disclosure provides a microbial genomic engineering method and system for transforming, screening, and selecting filamentous fungal cells that have altered morphology and/or growth under specific growth conditions. The method and system utilize high-throughput (HTP) methods to produce filamentous fungal production strains with a desired morphological phenotype.
The present disclosure describes the engineering of microbial cells for fermentative production of ectoine and provides novel engineered microbial cells and cultures, as well as related ectoine production methods.
The present disclosure relates to polymers and additives that may be used in energy storage applications, and more specifically, in liquid and solid-state electrolytes. The present disclosure further relates to batteries and capacitors containing the electrolytes.
The present invention relates to a polyimide resin including a fluorine atom and a structural unit derived from an aliphatic diamine, the imidation rate being 90% or higher and the weight average molecular weight (Mw) being 60,000 to 250,000 (inclusive).
C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
C08L 79/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
G09F 9/00 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements
G09F 9/30 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements in which the desired character or characters are formed by combining individual elements
The present invention relates to a laminated film including a polyimide-based film and a protective film, wherein a peeling force between the polyimide-based film and the protective film is less than 0.24 N/25.4 mm.
The present invention relates to an optical film: which contains a polyimide resin having a structural unit derived from an aliphatic diamine; which has a 350 nm light transmittance of 10% or lower; and which has a photoelastic coefficient of no greater than５０×１０－１２Ｐａ－１.
C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
C08L 79/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
G09F 9/00 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements
G09F 9/30 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements in which the desired character or characters are formed by combining individual elements
C08K 3/013 - Fillers, pigments or reinforcing additives
Provided herein are novel non-naturally occuring bacteria that exhibit enhanced nitrogen fixation activity. Such non-naturally occuring bacteria are useful in providing plants (e.g., food crops) with useable nitrogen nutrients and, therefore, enhancing plant growth and development. In some embodiments, the non-naturally occuring bacterium provided herein exhibits: 1) increased nifA expression; 2) decreased nifL expression; 3) increased rpoN expression; and 4) expression of a variant GlnD that has decreased uridylyl-removing activity.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
C05F 11/08 - Organic fertilisers containing added bacterial cultures, mycelia or the like
C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium
The present disclosure relates to methods and systems for decarboxylation of amino acids. In particular, such methods and systems can employ an organocatalyst to provide favorable reaction conditions.
B01J 8/06 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds in tube reactorsChemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds the solid particles being arranged in tubes
C07C 7/04 - Purification, separation or stabilisation of hydrocarbonsUse of additives by distillation
C07C 51/38 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groupsPreparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by hydrogenolysis of functional groups by decarboxylation
C12P 13/00 - Preparation of nitrogen-containing organic compounds
122 for each occasion independently are selected from a group of tetravalent moieties and B for each occasion independently is selected from a group of divalent moieties, wherein x is an integer greater than 1. The polyimide material has desirable optical, structural, thermal, mechanical properties, or combination thereof.
C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
B01D 71/64 - PolyimidesPolyamide-imidesPolyester-imidesPolyamide acids or similar polyimide precursors
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
73.
ENGINEERED BIOSYNTHETIC PATHWAYS FOR PRODUCTION OF L-HOMOCYSTEINE BY FERMENTATION
The present disclosure describes the engineering of microbial cells for fermentative production of L-homocysteine and provides novel engineered microbial cells and cultures, as well as related L-homocysteine production methods.
C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium
74.
HTP GENOMIC ENGINEERING PLATFORM FOR IMPROVING FUNGAL STRAINS
A HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols is provided. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. Methods for isolating clonal populations derived from individual fungal spores are also provided.
The present disclosure provides methods and systems for identifying insecticidal protein-encoding GIs (GIs). The present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to GI search bioinformatic tools and techniques.
The present disclosure addresses elastomeric adhesives and elastomers that include a modified amine. The modified amine can be the reaction product of an amine with a Michael acceptor. The amine can be represented by H2N—Ar—R1—NH2, wherein Ar is an arylene and R1 is selected from an alkylene and alkenylene. The Michael acceptor can be selected from a variety of compounds including maleates, fumarates, acrylates, and others.
The generation of a factory order includes receiving an expression indicating an operation on a first sequence operand and a second sequence operand. The first sequence operand represents multiple biological sequence parts, and the second sequence operand represents at least one biological sequence part. The expression is evaluated to a sequence specification, which represents modifications to at least one biological sequence, and comprises a data structure representing (a) the first and second sequence operands, (b) one or more first-level operations to be performed on one or more first-level sequence operands, and (c) one or more second-level operations, the execution of at least one of which resolves values of at least one of the first-level sequence operands. A factory order is generated based upon execution of at least one first-level operation and at least one second-level operation.
The present disclosure provides compositions and methods for detection of ectopic integration of a DNA fragment. The disclosure further provides a method for determining the quality of a genomic transformation.
The present disclosure describes the engineering of microbial cells for fermentative production of 4-APEA and related products and provides novel engineered microbial cells and cultures, as well as related 4-APEA production methods.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemicals for use in industry, chemistry and photography; powdered chemical substances for use in industry, chemistry and photography; homogeneous polyimide powders or filaments made from polyimide powders for use in 3D printing, including selective laser sintering or filamenting; polyimides for use as feedstock for 3D printing; polyimide powders for use in the manufacture of prototypes or custom parts for the automobile industry and the aerospace industry; polyimide powders for making custom made medical devices such as hearing aids; polyimide powders for use in the consumer industry to 3D printing of objects at home.
The present disclosure provides epoxy adhesive compositions with increased adhesion to surfaces, including metal surfaces, comprising a catechol modifier and methods of use thereof.
The present disclosure describes methods of polyimide synthesis and polyimides made therefore. The method includes placing a tetracarboxylic compound and a solvent in a reaction vessel and adding a first amount of a diamine. The first amount of the diamine is not more than 99.5 mol% of the tetracarboxylic compound inside the reaction vessel. The method can include agitating the mixture and determining a viscosity of the mixture. The method can further include adding a second amount of the diamine. The last steps can be repeated until the viscosity increases to a target value. The target viscosity can be correlated to a peak weight-averaged molecular weight of the polyimide.
The present disclosure describes methods of polyimide synthesis and polyimides made therefore. The method includes placing a tetracarboxylic compound and a solvent in a reaction vessel and adding a first amount of a diamine. The first amount of the diamine is not more than 99.5 mol% of the tetracarboxylic compound inside the reaction vessel. The method can include agitating the mixture and determining a viscosity of the mixture. The method can further include adding a second amount of the diamine. The last steps can be repeated until the viscosity increases to a target value. The target viscosity can be correlated to a peak weight-averaged molecular weight of the polyimide.
Provided herein are nucleic acid constructs comprising multiple guide RNAs interspersed with tRNA sequence at regular intervals as well as expression vectors and compositions comprising the same. Also provided herein are methods for assembling the nucleic acid constructs comprising multiple guide RNAs interspersed with tRNA sequence at regular intervals in a pooled and/or modular manner. Methods for using the nucleic acid constructs comprising multiple guide RNAs interspersed with tRNA sequence at regular intervals to facilitate multiplexed genomic editing of a host cell comprising said nucleic acid constructs are also provided herein.
Embodiments disclosed include systems and methods to generate and/or improve non-sporulating filamentous fungal cells using high-throughput techniques. Embodiments disclosed also include systems and methods for evaluation and iterative adjustment of methods to generate and/or isolate and select desired strains of non-sporulating filamentous fungal cells using high-throughput techniques.
The present disclosure describes the engineering of microbial cells for fermentative production of 2-oxoadipate and provides novel engineered microbial cells and cultures, as well as related 2-oxoadipate production methods.
C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
C12N 15/77 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for CorynebacteriumVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Brevibacterium
The present disclosure describes the engineering of microbial cells for fermentative production of 1,5-diaminopentane and provides novel engineered microbial cells and cultures, as well as related 1,5-diaminopentane production methods.
Embodiments disclosed include systems and methods to generate and/or improve non-sporulating filamentous fungal cells using high-throughput techniques. Embodiments disclosed also include systems and methods for evaluation and iterative adjustment of methods to generate and/or isolate and select desired strains of non-sporulating filamentous fungal cells using high-throughput techniques.
The present disclosure provides compositions and methods for gene editing. The disclosure also provides methods for removing extra-chromosomally replicating plasmids from competent cells.
The present disclosure relates to compositions derived from bioreachable molecules, such as amino acids or hydroxy acids. In particular, the composition can be a monomer, a polymer, or a copolymer derived from an amino acid dimer or a hydroxy acid dimer.
C07D 241/08 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
The present invention relates to a method for producing a long optical film, the method comprising a step for preparing a varnish by dissolving a polyimide resin in a solvent, wherein the polyimide resin contains aliphatic diamine-derived structural units, and the moisture absorption speed of the solvent per unit surface area is 25 mass%/h∙m2 or less as determined by the Karl Fischer method.
The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs). In some embodiments, the present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to MGC search bioinformatic tools and techniques.
G06N 3/12 - Computing arrangements based on biological models using genetic models
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
The present invention pertains to an optical film which has a glass transition temperature of 165ºC or higher, a light transmittance at a 350 nm wavelength of 10% or less, an in-plane phase difference of 30 nm or less, and a thickness phase difference of 100 nm or less.
G06F 3/041 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means
G09F 9/00 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements
G09F 9/30 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements in which the desired character or characters are formed by combining individual elements
The present invention relates to an optical film that includes a polyimide resin having a structural unit derived from an aliphatic diamine, has a glass transition temperature of 165°C or higher, and has a 350 nm light transmittance of 10% or lower.
G09F 9/00 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements
G09F 9/30 - Indicating arrangements for variable information in which the information is built-up on a support by selection or combination of individual elements in which the desired character or characters are formed by combining individual elements
The present invention pertains to a method for manufacturing an optical film, the method comprising: step (I) for dissolving a polyimide-based resin in a solvent to prepare a varnish; step (II) for applying the varnish onto a substrate to form a coating film; and step (III) for drying the coating film to form a film, wherein the polyimide-based resin contains a structural unit derived from an aliphatic diamine, the solvent in step (I) has a moisture absorption rate per unit area of at least 25 mass%/h·m2 as measured by the Karl Fischer method, and time T from the completion of the formation of the coating film in step (II) to the start of drying of the coating film in step (III) satisfies equation (A) [in equation (A), Vs represents the moisture absorption rate per minute (mass%/min) of the solvent as determined by the Karl Fischer method].
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
The present disclosure relates to compositions derived from bioreachable molecules, such as amino acids and/or steroids. In particular, the composition can be a monomer, a polymer, or a copolymer derived from an amino acid dimer. Such compositions can optionally include a functionalized steroid.
C07D 241/08 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
C07J 41/00 - Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
C07J 1/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, not substituted in position 17 beta by a carbon atom, e.g. oestrane, androstane
C07J 63/00 - Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
The present disclosure provides methods for predicting phenotypic performance of a host cell in industrial culture. Specifically, the present disclosure provides methods for predicting phenotypic performance of a host cell in industrial culture by determining the metabolite fingerprinting profile of a host cell in small lab-scale culture and applying said profile to a predictive model of phenotypic performance.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemicals for use in industry; coatings and powders for use in industry; homogeneous polyimide powders or filaments made from polyimide powders for use in 3D printing, including selective laser sintering or filamenting; polyimides for use as feedstock for 3D printing; polyimide powders for use in the manufacture of prototypes or custom parts for the automobile industry and the aerospace industry; polyimide powders for making custom made medical devices such as hearing aids; polyimide powders for use in the consumer industry to 3D printing of objects at home.
99.
FORMULATIONS OF BIOREACHABLE DOPANTS FOR LIQUID CRYSTALS
The present disclosure relates to formulations having one, two, or more chiral dopants, as well as materials and methods including such formulations. In particular instances, the formulation can include an achiral host, such as a nematic substance.
Methods, compositions, and kits for high throughput DNA assembly reactions in vitro. Modular CRISPR DNA constructs comprising modular insert DNA parts flanked by cloning tag segments comprising pre-validated CRISPR protospacer/protospacer adjacent motif sequence combinations.
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
