40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Custom manufacturing services using a proprietary technology
platform for capsule and any other oral solid dosage forms,
and encapsulation technologies. Scientific and technological consulting services in the
field of pharmaceutical development, specifically for the
formulation, customization and encapsulation of capsules and
other oral solid dosage forms; scientific and technological
consulting services for creating and providing capsule and
any other oral solid dosage form delivery solutions;
scientific and technological consulting services in relation
to capsule and any other oral solid dosage form expertise;
product development services using a proprietary technology
platform for capsule and any other oral solid dosage forms,
and encapsulation technologies.
3.
FILM-FORMING COMPOSITION CONTAINING SURFACTANT OR SURFACTANT AND SALT AS WHITENING AGENT
[Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.
[Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.
[Solution] Provided is a film, a capsule, and a film forming composition, characterized by comprising: a film-forming polymer; and a whitening agent including either a surfactant or both a surfactant and a salt, and characterized in that the surfactant is selected from a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and a saponin.
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Custom manufacturing services using a proprietary technology platform for capsule and any other oral solid dosage forms, and encapsulation technologies. Scientific and technological consulting services in the field of pharmaceutical development, specifically for the formulation, customization and encapsulation of capsules and other oral solid dosage forms; scientific and technological consulting services for creating and providing capsule and any other oral solid dosage form delivery solutions; scientific and technological consulting services in relation to capsule and any other oral solid dosage form expertise; product development services using a proprietary technology platform for capsule and any other oral solid dosage forms, and encapsulation technologies.
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Custom manufacturing services of products, using a proprietary technology platform for capsule and any other oral solid dosage forms, and encapsulation technologies. Scientific and technological consulting services in the field of pharmaceutical development, specifically for the formulation, customization, and encapsulation of capsules and other oral solid dosage forms; scientific and technological consulting services for creating and providing capsule and any other oral solid dosage form delivery solutions; scientific and technological consulting services in relation to capsule and any other oral solid dosage form expertise; product development services using a proprietary technology platform for capsule and any other oral solid dosage forms, and encapsulation technologies.
6.
GRAVURE PRINTING CYLINDER FOR PRINTING OF LARGE-SIZED TAGS
42 - Scientific, technological and industrial services, research and design
Goods & Services
Presentation of goods on communication media, for retail
purposes; retail and wholesale services for pharmaceutical
and nutraceutical preparations; online retail store services
relating to pharmaceutical and nutraceutical preparations;
online advertising on a computer network; provision of
online advertising, marketing services and business
information via a website; online ordering services;
providing commercial information to consumers; provision of
information and advice to consumers regarding the selection
of products and items to be purchased. Providing temporary use of non-downloadable software
applications accessible via a website; providing online,
non-downloadable software; hosting of platforms and portals
on the Internet; hosting of interactive applications;
providing temporary use of non-downloadable computer
software to enable sharing of multimedia content and
comments among users; providing temporary use of web-based
applications and software; providing temporary use of
on-line non-downloadable single sign-on software; providing
temporary use of on-line non-downloadable software for the
transmission and management of data; platform as a service
(PaaS); software as a services (SaaS); administration of
user rights in computer networks; user authentication
services using technology for e-commerce transactions;
computer programming services for the analysis of data;
technical data analysis services.
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Presentation of goods on communication media, on an ecommerce online platform, for retail purposes; retail services for pharmaceutical and nutraceutical preparations; online retail store services relating to pharmaceutical and nutraceutical preparations.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Presentation of goods on communication media, for retail purposes; retail and wholesale services for pharmaceutical and nutraceutical preparations; online retail store services relating to pharmaceutical and nutraceutical preparations; online advertising on a computer network; provision of online advertising, marketing services and business information via a website; online ordering services; providing commercial information to consumers; provision of information and advice to consumers regarding the selection of products and items to be purchased. Providing temporary use of non-downloadable software applications accessible via a website; providing online, non-downloadable software; hosting of platforms and portals on the Internet; hosting of interactive applications; providing temporary use of non-downloadable computer software to enable sharing of multimedia content and comments among users; providing temporary use of web-based applications and software; providing temporary use of on-line non-downloadable single sign-on software; providing temporary use of on-line non-downloadable software for the transmission and management of data; platform as a service (PaaS); software as a services (SaaS); administration of user rights in computer networks; user authentication services using technology for e-commerce transactions; computer programming services for the analysis of data; technical data analysis services.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Capsules coated with essential oils sold empty for pharmaceuticals; Capsules coated with synthetic-flavored oils sold empty for pharmaceuticals; all of the foregoing sold exclusively business to business
The present disclosure is directed to an oil-in-water emulsion containing at least one hygroscopic ingredient and an edible oil. The emulsion has a water activity of less than about 0.6. The emulsion may be incorporated into an oral dosage form, including a capsule oral dosage form. The ingredients provided in the emulsion are capable of improving the health or well-being of a human or animal.
Presentation of goods on communication media, on an Ecommerce online platform, for retail purposes; retail services for pharmaceutical and nutraceutical preparations; online retail store services relating to pharmaceutical and nutraceutical preparations.
[Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.
[Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.
[Solution] Provided is a film, a capsule, and a film forming composition, characterized by comprising: a film-forming polymer; and a whitening agent including either a surfactant or both a surfactant and a salt, and characterized in that the surfactant is selected from a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and a saponin.
The present invention discloses a sealing fluid comprising an organic acid, an alcohol and optionally water, the organic acid is lactic acid or acetic acid, the alcohol is isopropanol or ethanol, the sealing fluid is a liquid composition for sealing telescopically joined hard capsules with coaxial partly overlapping body parts.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Liquid filled medical preparation capsules for a wide variety of pharmaceuticals for pharmaceutical use; liquid filled diet capsules for use with nutritional supplements, all of the foregoing sold exclusively business to business
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Empty capsules for pharmaceutical use; gelatin capsules sold empty for pharmaceuticals for use with nutritional supplements; all of the foregoing sold exclusively business to business
The invention discloses double layered delayed-release hard capsules made by double dipping, that is by two consecutive dip molding steps on the same mold pin without removing the film, provided by the first dip molding step, from the mold pin between the two dip molding steps, but dipping the mold pin with this first film in the second dip molding step, each dip molding step is done with a different polymer melt, providing a double layered delayed-release capsule.
The present invention relates to a device for dispensing a single droplet of a fluid, for example a single droplet of an adhesive, onto the inside surface of a cap or onto the inside surface of a body of a capsule, this is useful for rendering a closed capsule with a telescopically engaged cap and body more tamperproof, or for fixing a cap or a body or both, which encloses a caplet or tablet or a part thereof, to the caplet or the tablet.
B65B 39/00 - Nozzles, funnels or guides for introducing articles or materials into containers or wrappers
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
B65B 7/28 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
B65B 51/02 - Applying adhesives or sealing liquids
B65B 51/10 - Applying or generating heat or pressure or combinations thereof
B65B 51/32 - Cooling, or cooling and pressing, package closures after heat-sealing
The present invention relates a dosing device, DOSDEV, for dosing solid particulate materialinto a receptacle, preferably into a capsule, the DOSDEV has a dosing element which has a tube shape which can be filled with the solid particulate material by sucking in the solid particulate material by means of a vacuum and wherein excess solid particulate material sticking to the entrance of the DOSDEV is blown off with gas.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
B65B 1/04 - Methods of, or means for, filling the material into the containers or receptacles
G01F 1/00 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
30.
METHOD FOR MAKING MULTIPARTICULATES FROM A LIQUID FEED EMPLOYING A SPINNING DISC SPRAYER
A process for making multiparticulates, comprising providing a molten feed comprising an active ingredient and an excipient, and providing a spinning disc sprayer comprising a rotating disc having a feed-receiving surface driven from above by a hollow drive shaft, wherein axes of rotation of the hollow drive shaft and rotatable disc are coaxial and a downward end of the hollow drive shaft is disposed with a distributor for regulating flow of the molten feed into the well, the distributor and the well together configured for providing a substantially radial, uniform outward flow of the molten feed across the feed-receiving surface.
B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
B05B 3/10 - Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements discharging over substantially the whole periphery of the rotating member
31.
Single-use spray drying components and methods of using the same
Spray drying method and systems are disclosed that include one or more single-use components. Single-use spray drying systems can include a drying chamber with an inner surface formed of a polymeric material. The single-use components can be pre-sterilized and sterile packaged to provide improved efficiencies and greater operational flexibility in spray drying systems.
F26B 3/12 - Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray
B01D 1/18 - Evaporating by spraying to obtain dry solids
B05B 7/16 - Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas incorporating means for heating the material to be sprayed
B05B 15/40 - Filters located upstream of the spraying outlets
F26B 25/14 - Chambers, containers, receptacles of simple construction
F26B 25/16 - Chambers, containers, receptacles of simple construction mainly closed, e.g. drum
A composition, such as a dietary composition is disclosed containing one or more capsaicinoids contained within a lipid matrix. In one embodiment, the composition contains a liquid capsaicin in addition to a capsaicin wax. The composition is formulated such that when is ingested does not break down in the stomach but instead releases the capsaicin in the small intestines for various dietary benefits, including appetite suppression.
The invention discloses hydroxypropyl methylcellulose (HPMC) capsules containing a small amount of CaCl2, which show reduced powder retention when used in Dry Powder Inhalers (DPI), and a method for making them.
The instant disclosure provides a capsule composition comprising pullulan, a setting system and a surfactant system that is a sucroglyceride or a sugar fatty acid ester, and methods for making such capsules.
Multiparticulate compositions including an active agent and a gelling agent are disclosed. The multiparticulate compositions are prepared by an aqueous-based spray and congeal process.
The present invention relates to a capsule shell with two parts, a cap and a body, the two parts engage telescopically with each other, the capsule shell is used for storing solid substances in powder or granular form and shows a minimized leakage rate of powder when the capsule shell is filled with the solid substances in powder form and is closed.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
38.
MIXED SOLVENTS FOR SPRAY DRYING FOR PREPARATION OF AMORPHOUS SOLID DISPERSIONS
A method for preparing an amorphous solid dispersion by spray drying a spray solution comprising a) a mixed solvent, the mixed solvent comprising i. a solvent 1 selected from the group consisting of methyl acetate, methyl formate, ethyl acetate, ethyl formate and mixtures thereof; ii. a solvent 2 selected from the group consisting of methanol, ethanol and mixtures thereof; with the ratio (w:w) of solvent 1 to solvent 2 being from 10:90 to 90:10; b) an active agent; c) a dispersion polymer, wherein: c1) said dispersion polymer is HPMC; or c2) said dispersion polymer is PVP, provided that said mixed solvent does not consist of a mixture of methanol and ethyl acetate; or c3) said dispersion polymer is selected from the group consisting of: hydroxypropyl methylcellulose acetate succinate (HPMCAS), hydroxypropyl methylcellulose phthalate (HPMCP), hydroxypropyl cellulose (HPC), cellulose acetate phthalate (CAP), carboxymethyl ethyl cellulose (CMEC), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA), polymethacrylates such as poly(methacrylic acid-co-methyl methacrylate) (PMMAMA) or poly(methacrylic acid-co-ethyl acrylate), [acetic acid ethenyl ester, polymer with 1-ethenylhexahydro-2H- azepin-2-one and. alpha. -hydro-. omega. -hydroxypoly(oxy-I,2- ethanediyl), graft], or a combination thereof.
A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
39.
SPRAY DRYING OF API IN SUPERSATURATED SOLUTIONS WITH FORMIC ACID
The invention discloses a method for preparation of spray dried solid dispersions (SDD)comprising an active pharmaceutical ingredient (API) and a dispersion polymer (DISPPOL), wherein the spray drying is done with a supersaturated solution of API in a solvent mixture comprising two solvents, this supersaturated solution further comprising DISPPOL.
A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid component including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in a solution with L-carnitine. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building z composition can be administered in a monolithic enteric capsule.
A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid derivative including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in an acid resistant capsule delivery form. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building composition can be administered in a monolithic enteric capsule.
A nozzle assembly includes a nozzle, a manifold, and wand body. The nozzle, manifold, and wand body can be coupled together to provide a robust spray drying system that can withstand elevated temperature and/or pressure feed stock. In some embodiments, an internal shoulder portion of the manifold can engage with a side of a nozzle collar to restrict distal movement of the nozzle relative to the manifold.
B05B 7/06 - Spray pistolsApparatus for discharge with one outlet orifice surrounding another approximately in the same plane
B05B 7/10 - Spray pistolsApparatus for discharge producing a swirling discharge
F26B 3/12 - Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray
F26B 21/14 - Arrangements for supplying or controlling air or gases for drying solid materials or objects using gases or vapours other than air or steam
44.
Particles Containing a Lipid Matrix Core and Active Ingredient
A composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein is disclosed. The active ingredient can include a fat-soluble active ingredient. The particles can be contained in a capsule. Also provided are methods for producing a pharmaceutical composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein.
An aqueous composition for making dip-molded comestible hard capsules comprising a film forming capsule base material and one or more colorants each consisting of a hydrophilic coloring foodstuff concentrate.
Ammonia is used as a processing aid in a method for forming a sprayed solid dispersion comprising an active agent, wherein the active agent, in a free acid form, has a pKa≤7 and a solubility≤40 mg/mL in the spray solvent. Ammonia is subsequently removed from the sprayed solid dispersion. Sprayed solid dispersions formed by the disclosed method are also disclosed.
A61K 31/655 - Azo (—N=N—), diazo (=N2), azoxy (N—O—N or N(=O)—N), azido (—N3) or diazoamino (—N=N—N) compounds
A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
The present application is directed to methods for modulating afucosylation of an antibody product that is produced in a bioreactor. The methods include the addition of mannose to the bioreactor to control the afucosylation of the antibody product, including increasing by afucosylation by 1% or more, relative to untreated bioreactor products.
The present disclosure is directed to an extended release composition containing Vitamin C in a lipid matrix, which releases the Vitamin C over a period of time.
The present disclosure is directed to an extended release composition containing Vitamin C in a lipid matrix, which releases the Vitamin C over a period of time.
A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
53.
EXTENDED RELEASE VITAMIN C AND MANUFACTURING THEREOF
The present disclosure is directed to an extended release composition containing Vitamin C in a lipid matrix, which releases the Vitamin C over a period of time.
Problem to be solved: To provide a whitened or opacified capsule and film without using a white pigment such as titanium dioxide. Solution: A film, a capsule and a film-forming composition characterized by containing a film-forming polymer component selected from gelatin and pullulan and an opacifying agent consisting of a water-soluble salt except calcium salt carbonate and bicarbonate, wherein the salt is selected from a sodium salt, potassium salt, an ammonium salt and a magnesium salt.
The present invention discloses a sealing fluid comprising an organic acid, an alcohol and optionally water, the organic acid is lactic acid or acetic acid, the alcohol is isopropanol or ethanol, the sealing fluid is a liquid composition for sealing telescopically joined hard capsules with coaxial partly overlapping body parts.
A61J 1/00 - Containers specially adapted for medical or pharmaceutical purposes
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
The invention discloses double layered delayed-release hard capsules made by double dipping, that is by two consecutive dip molding steps on the same mold pin without removing the film, provided by the first dip molding step, from the mold pin between the two dip molding steps, but dipping the mold pin with this first film in the second dip molding step, each dip molding step is done with a different polymer melt, providing a double layered delayed-release capsule.
The invention discloses double layered delayed-release hard capsules made by double dipping, that is by two consecutive dip molding steps on the same mold pin without removing the film, provided by the first dip molding step, from the mold pin between the two dip molding steps, but dipping the mold pin with this first film in the second dip molding step, each dip molding step is done with a different polymer melt, providing a double layered delayed-release capsule.
The present invention relates to inhalable dry powder formulations comprising one or more antibodies or one or more angiogenesis inhibiting active pharmaceutical ingredients, methods of manufacture of such compositions, e.g. via spray drying, as well as their local administration to the lung for use in the treatment, prevention and/or delay of progression of asthma, COPD, lung infections, cystic fibrosis, or lung cancer.
The present invention relates to a device DEV for dispensing a single droplet of a fluid, for example a single droplet of a adhesive, onto the inside surface of a cap or onto the inside surface of a body of a capsule, this is useful for rendering a closed capsule with a telescopically engaged cap and body more tamperproof, or for fixing a cap or a body or both, which encloses a caplet or tablet or a part thereof, to the caplet or the tablet.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
A61B 17/00 - Surgical instruments, devices or methods
B65B 51/02 - Applying adhesives or sealing liquids
64.
ACETIC ACID AS PROCESSING AID IN SPRAY DRYING FOR BASIC DRUGS
This invention discloses amorphous solid dispersions ASDs comprising darolutamide and a dispersion polymer, pharmaceutical dosage forms (PDF) comprising said ASD, such as capsules, tablets or caplets, and a method for preparing said ASDs.
The invention discloses a method for preparation of spray dried solid dispersions (SDD) comprising an active pharmaceutical ingredient (API) and a dispersion polymer (DISPPOL), wherein the spray drying is done with a supersaturated solution of API in a solvent mixture comprising two solvents, one is acetic acid, this supersaturated solution further comprising DISPPOL.
[Technical Problem] A problem of the present invention is, in one aspect, to provide a capsule formulation including an active ingredient and the like that may deteriorate upon contacting an acid, wherein the capsule formulation makes it possible not to deteriorate the active ingredient and the like by a gastric acid which enters into a capsule film.
[Technical Problem] A problem of the present invention is, in one aspect, to provide a capsule formulation including an active ingredient and the like that may deteriorate upon contacting an acid, wherein the capsule formulation makes it possible not to deteriorate the active ingredient and the like by a gastric acid which enters into a capsule film.
[Technical Solution] A capsule formulation comprising an active ingredient and oil, wherein said capsule of said formulation is an enteric capsule comprising a water soluble film forming polymer and gellan gum; said oil is an oil acceptable for pharmaceuticals or foods; and said active ingredient is encapsulated in said capsule together with said oil, and the production method thereof, are provided.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61K 9/00 - Medicinal preparations characterised by special physical form
B65B 3/04 - Methods of, or means for, filling the material into the containers or receptacles
B65B 7/28 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
B65D 65/46 - Applications of disintegrable, dissolvable or edible materials
A composition, such as a dietary composition is disclosed containing one or more capsaicinoids contained within a lipid matrix. In one embodiment, the composition contains a liquid capsaicin in addition to a capsaicin wax. The composition is formulated such that when is ingested does not break down in the stomach but instead releases the capsaicin in the small intestines for various dietary benefits, including appetite suppression.
A23D 7/00 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines
A23L 27/10 - Natural spices, flavouring agents or condimentsExtracts thereof
A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
A23L 33/115 - Fatty acids or derivatives thereofFats or oils
A23D 7/005 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
A composition, such as a dietary composition is disclosed containing one or more capsaicinoids contained within a lipid matrix. In one embodiment, the composition contains a liquid capsaicin in addition to a capsaicin wax. The composition is formulated such that when is ingested does not break down in the stomach but instead releases the capsaicin in the small intestines for various dietary benefits, including appetite suppression.
A23D 7/00 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines
A23D 7/005 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
A23L 27/10 - Natural spices, flavouring agents or condimentsExtracts thereof
A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
A23L 33/115 - Fatty acids or derivatives thereofFats or oils
A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
70.
METHOD FOR MAKING MULTIPARTICULATES FROM A LIQUID FEED EMPLOYING A SPINNING DISC SPRAYER
A process for making multiparticulates, comprising providing a molten feed comprising an active ingredient and an excipient, and providing a spinning disc sprayer (100) comprising a rotating disc (110) having a feed-receiving surface (112) driven from above by a hollow drive shaft (A-A'), wherein axes of rotation of the hollow drive shaft (A-A') and rotatable disc (B-B') are coaxial and a downward end (22) of the hollow drive shaft (200) is disposed with a distributor (204) for regulating flow of the molten feed into the well (116), the distributor (204) and the well (116) together configured for providing a substantially radial, uniform outward flow of the molten feed across the feed-receiving surface (112).
B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
B05B 3/10 - Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements discharging over substantially the whole periphery of the rotating member
71.
METHOD FOR MAKING MULTIPARTICULATES FROM A LIQUID FEED EMPLOYING A SPINNING DISC SPRAYER
A process for making multiparticulates, comprising providing a molten feed comprising an active ingredient and an excipient, and providing a spinning disc sprayer (100) comprising a rotating disc (110) having a feed-receiving surface (112) driven from above by a hollow drive shaft (A-A'), wherein axes of rotation of the hollow drive shaft (A-A') and rotatable disc (B-B') are coaxial and a downward end (22) of the hollow drive shaft (200) is disposed with a distributor (204) for regulating flow of the molten feed into the well (116), the distributor (204) and the well (116) together configured for providing a substantially radial, uniform outward flow of the molten feed across the feed-receiving surface (112).
B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
B05B 3/10 - Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements discharging over substantially the whole periphery of the rotating member
This disclosure concerns oral pharmaceutical compositions comprising a solid dosage form (SDF). The SDF comprises (i) a solid amorphous dispersion (SAD) comprising a poorly water soluble active agent and a matrix material comprising poly[(methyl methacrylate)-co-(methacrylic acid)] (PMMAMA), and (ii) a concentration-sustaining polymer (CSP), wherein the CSP is not dispersed in the SAD, and the SAD is at least 35 wt % of the SDF. The SAD and CSP together may be at least 50 wt % of the SDF. The SDF may be, for example, a tablet, a caplet, or a capsule.
This invention discloses amorphous solid dispersions ASD comprising acalabrutinib and HPMCAS, oral dosage forms comprising said ASD, such as capsules, tablets or caplets, and a method for preparing said ASDs.
The invention discloses hydroxypropyl methylcellulose (HPMC) capsules containing a small amount of CaCl2, which show reduced powder retention when used in Dry Powder Inhalers (DPI), and a method for making them.
[Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.
[Solution] Provided is a film, a capsule, and a film forming composition, characterized by comprising: a film-forming polymer; and a whitening agent including either a surfactant or both a surfactant and a salt, and characterized in that the surfactant is selected from a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and a saponin.
A hard capsule improved in elastic modulus, breaking strength and oxygen impermeability, the hard capsule being characterized by containing a cellulose derivative as a base material and also containing a mechanical strength improver comprising at least one water-soluble substance selected from the group consisting of pullulan, gum arabic, a guar gum decomposition product, glucomannan, sodium polyacrylate and cyclodextrin.
The present disclosure relates to lipid-based formulations, lipid formulations or compositions comprising lipophilic salts and acidic pH modifiers. The acidic pH modifiers are able to yield stabilized lipid formulations and/or to increase the solubility of the lipophilic salts in the lipid formulations.
A composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein is disclosed. The active ingredient can include a fat-soluble active ingredient. The particles can be contained in a capsule. Also provided are methods for producing a pharmaceutical composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein.
The present invention relates to a capsule shell with two parts, a cap and a body, the two parts engage telescopically with each other, the capsule shell is used for storing solid substances in powder or granular form and shows a minimized leakage rate of powder when the capsule shell is filled with the solid substances in powder form and is closed.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
The present invention relates to a capsule shell with two parts, a cap and a body, the two parts engage telescopically with each other, the capsule shell is used for storing solid substances in powder or granular form and shows a minimized leakage rate of powder when the capsule shell is filled with the solid substances in powder form and is closed.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
A nozzle assembly includes a nozzle, a manifold, and wand body. The nozzle, manifold, and wand body can be coupled together to provide a robust spray drying system that can withstand elevated temperature and/or pressure feed stock. In some embodiments, an internal shoulder portion of the manifold can engage with a side of a nozzle collar to restrict distal movement of the nozzle relative to the manifold.
F26B 3/12 - Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray
B05B 7/10 - Spray pistolsApparatus for discharge producing a swirling discharge
A nozzle assembly includes a nozzle, a manifold, and wand body. The nozzle, manifold, and wand body can be coupled together to provide a robust spray drying system that can withstand elevated temperature and/or pressure feed stock. In some embodiments, an internal shoulder portion of the manifold can engage with a side of a nozzle collar to restrict distal movement of the nozzle relative to the manifold.
F26B 3/12 - Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray
B05B 7/10 - Spray pistolsApparatus for discharge producing a swirling discharge
A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid component including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in a solution with L-carnitine. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building composition can be administered in a monolithic enteric capsule.
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
A61K 31/205 - Amine addition salts of organic acidsInner quaternary ammonium salts, e.g. betaine, carnitine
The present disclosure is directed to an oil-in-water emulsion containing at least one hygroscopic ingredient and an edible oil. The emulsion has a water activity of less than about 0.6. The emulsion may be incorporated into an oral dosage form, including a capsule oral dosage form. The ingredients provided in the emulsion are capable of improving the health or well-being of a human or animal.
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A23P 10/00 - Shaping or working of foodstuffs characterised by the products
91.
METHOD AND COMPOSITION FOR INCREASING MUSCLE PROTEIN SYNTHESIS
A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid component including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in a solution with L-carnitine. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building composition can be administered in a monolithic enteric capsule.
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
A61K 31/205 - Amine addition salts of organic acidsInner quaternary ammonium salts, e.g. betaine, carnitine
92.
METHOD AND COMPOSITION FOR INCREASING MUSCLE PROTEIN SYNTHESIS
A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid derivative including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in an acid resistant capsule delivery form. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building composition can be administered in a monolithic enteric capsule.
A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid derivative including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in an acid resistant capsule delivery form. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building composition can be administered in a monolithic enteric capsule.
