Abstract

The present invention relates generally to machine learning and artificial intelligence methods of cell anomaly detection. More specifically, the present invention relates to targeting intracellular anomalies via microscopy-based high-content phenotypic screening and generative neural networks for combinatorial drug screening. As can be seen from the provided description, the claimed invention represents the system and method of cell anomaly detection, which increase reliability of cell anomaly detection. More specifically, the claimed invention provides an assessment of cell inter-component (inter-organelle) organization for detecting cell anomaly.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

A polynucleotide is provided. The polynucleotide encoding a chimeric polypeptide comprising an amino acid sequence of an immune checkpoint molecule capable of binding a ligand thereof, the immune checkpoint molecule being translationally fused to another amino acid sequence of a cell signaling module such that upon binding of the immune checkpoint molecule to the ligand, the cell signaling module is activated. Also provided other configurations of the polynucleotide, cells comprising the polynucleotides and methods of using the cells expressing the polynucleotides.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/725 - T-cell receptors
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A polynucleotide encoding a chimeric polypeptide comprising an amino acid sequence of a ligand capable of binding a cancer-associated receptor is provided. The amino acid sequence of the ligand being translationally fused to a heterologous amino acid sequence of a cell signaling module such that upon binding of the amino acid sequence of the ligand to the receptor, the cell signaling module is activated, wherein the ligand or cancer-associated receptor is not an immune checkpoint molecule.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/18 - Growth factorsGrowth regulators
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A flying driving vehicle having a body, a driving interface coupled to the body configured to enable the body to drive on a surface, and one or more driving actuators configured to provide power to the driving interface, a set of propellers coupled to the body, where the propellers' movement keeps the vehicle in place when the surface is in slope, and a controller for controlling the speed of the driving interface, a rotation speed of the set of propellers and a magnitude and direction of thrust applied by the set of propellers.

IPC Classes  ?

• B64U 60/55 - Undercarriages with landing legs the legs being also used as ground propulsion
• A47L 1/02 - Power-driven machines or devices
• B64U 10/60 - Tethered aircraft
• B64U 50/13 - Propulsion using external fans or propellers

Abstract

Provided are methods of treating a subject having a disease associated with a polyalanine expansion mutation, by administering to the subject a therapeutically effective amount of an agent capable of upregulating expression or activity of a ubiquitin like modifier activating enzyme 6 (UBA6) in nervous system cells of the subject. Also provided are methods of increasing ubiquitination of an E6AP polypeptide in a cell by an agent capable of specifically upregulating expression or activity of UBA6 and methods of screening for agent capable of specifically modulating expression or activity of UBA6.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 5/0793 - Neurons
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

Mutant aminoacyl-tRNA synthetase (aaRS) proteins are provided. Nucleic acid molecules encoding the mutant aaRSs, orthogonal translation systems comprising the mutant aaRSs or nucleic acid molecules, cells comprising the orthogonal translation systems, as well as methods of using same are also provided.

IPC Classes  ?

• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes

Abstract

The subject matter discloses a method for replacing a battery for a first vehicle, comprising a second vehicle placing the battery above the first vehicle; releasing the battery from the second vehicle to an inlet in the first vehicle; carrying the battery in a compartment of the first vehicle; coupling the battery to electronic circuitry in the first vehicle, such that the electronic circuitry receives electronic power from the battery. The subject matter also discloses an aerial vehicle used to receive a replacing battery, and a battery replacement system.

IPC Classes  ?

• B60L 53/80 - Exchanging energy storage elements, e.g. removable batteries
• B64D 27/24 - Aircraft characterised by the type or position of power plants using steam or spring force
• B64F 5/50 - Handling or transporting aircraft components
• H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells

Abstract

Compounds capable of interacting with the calmodulin-PIP2 binding domain of the SK4 channel to thereby interfere with the Ca2+-dependent activation of the SK4 channel and uses thereof in downregulating an activity of an SK4 channel in a subject in need thereof, are disclosed. Also disclosed is a method of identifying a candidate compound that is capable of downregulating an activity of SK4 channel, based on its interaction with the calmodulin-PIP2 binding domain of the SK4 channel.

IPC Classes  ?

• C07D 235/24 - BenzimidazolesHydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• C07D 235/26 - Oxygen atoms
• C07D 235/28 - Sulfur atoms
• C07D 235/30 - Nitrogen atoms not forming part of a nitro radical
• C07D 263/58 - BenzoxazolesHydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61P 35/00 - Antineoplastic agents
• A61P 9/04 - Inotropic agents, i.e. stimulants of cardiac contractionDrugs for heart failure
• A61P 9/06 - Antiarrhythmics

Abstract

The invention provides a method of electrochemical detection of clozapine in a whole blood sample or plasma sample, e.g., capillary sample, using an electrochemical microsensor comprising an array of working microelectrodes, i.e., bare and coated; by application of voltammetry and measurement of current as the electrochemical signal, a data set consisting of plurality of electrochemical signals is obtained, to which chemometric methods are applied to quantify clozapine in the sample.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes
• G01N 27/48 - Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage

Abstract

The present invention includes mutants of human alpha-1-antitrypsin (mhAAT). Further provided are compositions including the mhAAT and use of same, such as for modulating an immune cell, and treating a condition, such as inflammation.

IPC Classes  ?

• C07K 14/81 - Protease inhibitors
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

Provided are methods of in vitro maturation of spermatogonium by culturing the spermatogonium in a three-dimensional methylcellulose culture system (MCS) in a culture medium which comprises an effective concentration of a factor selected from the group consisting of granulocyte macrophages-colony stimulating factor (GM-CSF), interleukin-1 alpha (IL-1alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6), under conditions capable of differentiating the spermatogonium into at least meiotic and/or postmeiotic cells, thereby in vitro maturing the spermatogonium.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/076 - Sperm cellsSpermatogonia
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 35/52 - SpermProstateSeminal fluidLeydig cells of testes
• A61P 15/00 - Drugs for genital or sexual disordersContraceptives

Abstract

Disclosed herein is a device comprising a microelectrode comprising cells cultured on a surface of the microelectrode and a porous membrane comprising an upper surface comprising cultured cells. Further, devices and methods for in in-vitro models of the blood-brain barrier (BBB) and for modeling the transport across this barrier are disclosed.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

A non-transitory computer readable medium for detection of objects of one or more given classes, the non-transitory computer readable medium stores instructions for: performing an aerial images based (AIB) detection to find multiple object locations; wherein the performing of the AIB detection comprises applying an AIB detection machine learning process on aerial images; performing a ground-level based (GLB) detection of the objects, based on the multiple object locations; wherein the performing of the GLB detection comprises applying a GLB detection machine learning process on ground-level images; and classifying, by a classification machine learning process, objects captured in the ground-level images to a plurality of classes, wherein the plurality of classes comprise the one or more given classes; and responding to the classifying, when finding one or more objects of the one or more given classes.

IPC Classes  ?

• G06V 10/70 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning
• G06V 20/10 - Terrestrial scenes
• G06K 9/62 - Methods or arrangements for recognition using electronic means

Abstract

A flying driving vehicle, comprising a body; a driving interface coupled to the body, configured to enable the body to drive on a surface and one or more driving actuators configured to provide power to the driving interface; a set of propellers coupled to the body; wherein the propellers' movement keep the vehicle in place when the surface is in slope; a controller for controlling the speed of the driving interface, a rotation speed of the set of propellers and a magnitude and direction of thrust applied by the set of propellers

IPC Classes  ?

• A47L 1/02 - Power-driven machines or devices
• F24S 40/20 - CleaningRemoving snow
• H02S 40/10 - Cleaning arrangements
• E04G 23/00 - Working measures on existing buildings

Abstract

A polynucleotide is provided. The polynucleotide encoding a chimeric polypeptide comprising an amino acid sequence of an immune checkpoint molecule capable of binding a ligand thereof, the immune checkpoint molecule being translationally fused to another amino acid sequence of a cell signaling module such that upon binding of the immune checkpoint molecule to the ligand, the cell signaling module is activated. Also provided other configurations of the polynucleotide, cells comprising the polynucleotides and methods of using the cells expressing the polynucleotides.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/725 - T-cell receptors
• C12N 5/078 - Cells from blood or from the immune system
• C12N 5/09 - Tumour cells
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

A polynucleotide is provided. The polynucleotide encoding a chimeric polypeptide comprising an amino acid sequence of an immune checkpoint molecule capable of binding a ligand thereof, the immune checkpoint molecule being translationally fused to another amino acid sequence of a cell signaling module such that upon binding of the immune checkpoint molecule to the ligand, the cell signaling module is activated. Also provided other configurations of the polynucleotide, cells comprising the polynucleotides and methods of using the cells expressing the polynucleotides.

IPC Classes  ?

• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 5/078 - Cells from blood or from the immune system
• C12N 5/09 - Tumour cells
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/725 - T-cell receptors
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

In one aspect, the invention relates to an integrated circuit lab-on-chip bio-sensor, comprising: (a) a fluid compartment configured to receive a fluid; (b) a sensing layer at the bottom of the fluid compartment, the sensing layer has a top surface comprising molecules that are sensitive to target molecules of the fluid; (c) a readout structure in communication with the sensing layer, the readout circuit is configured to output a signal which is proportional to a sensing of target molecules by the sensing layer; and (d) at least one isolated electrode which is isolated from the fluid, the isolated electrode is configured to apply an electric field along at least an interface between the sensing layer and the fluid that in turn reduces or eliminates excess ion concentration along the interface during sensing.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

In a first embodiment, the invention relates to a method for nanoimprinting a pattern on a chalcogenide-glass substrate, comprising: (A) preparing a soft operational mold, the operational mold comprising an elastomeric matrix and a reinforcement, wherein the matrix is transparent to IR radiation, and the reinforcement is opaque to IR radiation, and the mold further includes a pattern to be replicated to the substrate; (B) placing the mold on a top surface of a chalcogenide-glass substrate to form a structure, and simultaneously applying (i) IR radiation to heat an area at a top surface of the substrate to a temperature T>Tg, where Tg is the glass transition temperature of chalcogenide-glass, and (ii) applying a controlled pressure on the mold to effect penetration to the top surface of the chalcogenide-glass substrate, thereby to replicate the pattern of the mold to the top surface of the substrate; and (C) separating the operational mold from the patterned substrate.

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate

Abstract

The invention relates to a system for determining a level of nitrate in a water sample, including: (a) an optical flow cell which is at least partially transparent and which is configured to contain a sample of water; (b) a first illuminator for illuminating the sample by light in a first wavelength, and a first photodetector for collecting the first-wavelength illumination, following the light passage through the sample; (c) a second illuminator for illuminating the sample within the cell by light in a second, fluorescence-exciting wavelength, and a second photodetector for collecting illumination in a third, fluorescence-emission wavelength from the sample; and (d) an analysis unit for determining the combined effect of nitrate+DOC within the sample on the absorbance of light, determining a concentration of DOC within the sample based on fluorescence emission from the sample, and subtracting the effect of DOC from the combined effect of nitrate+DOC on the absorbance, thereby to determine a concentration of nitrate within the sample.

IPC Classes  ?

• G01N 33/18 - Water
• G01N 21/05 - Flow-through cuvettes

Abstract

A method of in-situ estimating volume and mass of a plurality of objects comprises: (a) obtaining at least one image including said plurality of objects; (b) detecting said of objects within said image; (c) individually contouring said objects; (d) individually modelling shapes of said objects; and (e) individually estimating a volume and mass of said objects.

IPC Classes  ?

• G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
• G06V 20/68 - Food, e.g. fruit or vegetables
• G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries

Abstract

2) coating onto a progressively etched nickel surface; and partial electrochemical oxidation of said metallic ruthenium to ruthenium oxide. The electrode produced and a pseudo-capacitor based on the electrode are also disclosed.

IPC Classes  ?

• H01G 11/86 - Processes for the manufacture of hybrid or EDL capacitors, or components thereof specially adapted for electrodes
• H01G 11/40 - Fibres
• C25D 3/54 - ElectroplatingBaths therefor from solutions of metals not provided for in groups
• C25D 5/40 - NickelChromium
• H01G 11/46 - Metal oxides
• H01G 11/52 - Separators
• H01G 11/62 - Liquid electrolytes characterised by the solute, e.g. salts, anions or cations therein

Abstract

The invention relates to an input or output facet for an on-chip optical waveguide, the facet comprising a grid of gradually expanding unit-cells such as cones or pyramids.

IPC Classes  ?

• G02B 6/26 - Optical coupling means
• G02B 1/118 - Anti-reflection coatings having sub-optical wavelength surface structures designed to provide an enhanced transmittance, e.g. moth-eye structures
• G02B 6/122 - Basic optical elements, e.g. light-guiding paths

Abstract

The present invention relates to antibacterial carbon dots, having aminoguanidine functionality on their outermost surface. The invention further relates to the synthesis of said antibacterial carbon dots, and to the uses of these carbon dots for inhibiting a biofilm formation in the presence of said carbon dots and as fluorescent labeling markers for specific bacteria.

IPC Classes  ?

• A01N 25/26 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
• A01N 35/10 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen containing a carbon-to-nitrogen double bond
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The subject matter discloses a method for replacing a battery for a first vehicle, comprising a second vehicle placing the battery above the first vehicle; releasing the battery from the second vehicle to an inlet in the first vehicle; carrying the battery in a compartment of the first vehicle; coupling the battery to electronic circuitry in the first vehicle, such that the electronic circuitry receives electronic power from the battery. The subject matter also discloses an aerial vehicle used to receive a replacing battery, and a battery replacement system.

IPC Classes  ?

• B60L 53/80 - Exchanging energy storage elements, e.g. removable batteries
• B60S 5/06 - Supplying batteries to, or removing batteries from, vehicles
• B60L 58/12 - Methods or circuit arrangements for monitoring or controlling batteries or fuel cells, specially adapted for electric vehicles for monitoring or controlling batteries responding to state of charge [SoC]
• B64D 1/02 - Dropping, ejecting, or releasing articles

Abstract

Methods and compositions for increasing one or more plant growth characteristics in a plant are disclosed. The compositions comprise one or more microbial isolates that promote plant growth. Methods include providing an effective amount of a composition comprising one or more microbial isolates that promote one or more plant growth characteristics.

IPC Classes  ?

• A01N 63/20 - BacteriaSubstances produced thereby or obtained therefrom
• A01N 63/22 - Bacillus
• A01N 63/25 - Paenibacillus
• A01N 63/28 - Streptomyces
• C12N 1/20 - BacteriaCulture media therefor
• C12R 1/01 - Bacteria or actinomycetales
• C12R 1/07 - Bacillus
• C12R 1/29 - Micromonospora

Abstract

Provided are methods of in vitro maturation of spermatogonium by culturing the spermatogonium in a three-dimensional methylcellulose culture system (MCS) in a culture medium which comprises an effective concentration of a factor selected from the group consisting of granulocyte macrophages-colony stimulating factor (GM-CSF), interleukin- 1 alpha (IL-1 alpha), interleukin- 1 beta (IL-lbeta) and interleukin-6 (IL-6), under conditions capable of differentiating the spermatogonium into at least meiotic and/or postmeiotic cells, thereby in vitro maturing the spermatogonium.

IPC Classes  ?

• C12N 5/076 - Sperm cellsSpermatogonia
• A61K 35/52 - SpermProstateSeminal fluidLeydig cells of testes
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A master-slave scheduling system, comprising (a) a master DRL unit comprising: (i) a queue containing a plurality of item-representations; (ii) a master policy module configured to select a single item-representation from the queue and submit to the slave unit; (iii) a master DRL agent configured to (a) train the master policy module; and (b) receive an updated item-representation from the slave unit, and update the queue; (b) The slave DRL unit comprising: (i) a slave policy module receiving a single item-representation, selecting a single task entry and submitting to a slave environment for performance; (ii) a slave DRL agent configured to: (a) train the slave policy module; (b) receive an item-representation from the master DRL unit, and submit to the slave policy module; (c) receive an updated item-representation from the slave's environment, and submit the same to the master DRL unit; and (iii) the slave DRL agent.

IPC Classes  ?

• G06F 9/46 - Multiprogramming arrangements
• G06F 9/48 - Program initiatingProgram switching, e.g. by interrupt
• G06F 9/50 - Allocation of resources, e.g. of the central processing unit [CPU]
• G06F 18/214 - Generating training patternsBootstrap methods, e.g. bagging or boosting

Abstract

A high-frequency resonant power conversion system for transferring power from an oscillator to a load or vice-versa, the system including components with at least one fluctuating parameter and is configured to control the value of a defined variable selected from: a certain current, a certain voltage, a phase difference between a certain voltage and a certain current, and a certain power; the system further including a virtual impedance creation loop which is configured to create a virtual component, the virtual component forming a basis for changing amplitude and a phase of the oscillator, thereby to compensate for a deviation from the controlled variable due to the fluctuations.

IPC Classes  ?

• H02M 5/08 - Conversion of AC power input into AC power output, e.g. for change of voltage, for change of frequency, for change of number of phases without intermediate conversion into DC by static converters using impedances using capacitors only
• H02M 5/16 - Conversion of AC power input into AC power output, e.g. for change of voltage, for change of frequency, for change of number of phases without intermediate conversion into DC by static converters using transformers for conversion of frequency
• H02M 5/297 - Conversion of AC power input into AC power output, e.g. for change of voltage, for change of frequency, for change of number of phases without intermediate conversion into DC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal for conversion of frequency
• H02M 1/44 - Circuits or arrangements for compensating for electromagnetic interference in converters or inverters

Abstract

The invention relates to a system for determining a level of nitrate in a water sample, comprising: (a) an optical flow cell which is at least partially transparent and which is configured to contain a sample of water; (b) a first illuminator for illuminating the sample by light in a first wavelength, and a first photodetector for collecting the first-wavelength illumination, following the light passage through the sample; (c) a second illuminator for illuminating the sample within the cell by light in a second, fluorescence-exciting wavelength, and a second photodetector for collecting illumination in a third, fluorescence-emission wavelength from the sample; and (d) an analysis unit for determining the combined effect of nitrate+DOC within the sample on the absorbance of light, determining a concentration of DOC within the sample based on fluorescence emission from the sample, and subtracting the effect of DOC from the combined effect of nitrate+DOC on the absorbance, thereby to determine a concentration of nitrate within the sample.

IPC Classes  ?

• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/28 - Investigating the spectrum
• G01J 3/42 - Absorption spectrometryDouble-beam spectrometryFlicker spectrometryReflection spectrometry
• G01N 21/33 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
• G01N 33/18 - Water

Abstract

The present invention relates to a robotic maneuvering system for maneuvering objects by means of an adhesive attachment. The robotic maneuvering system comprises a gripper finger connected to a gripper arm. The gripper finger is configured to grasp an object to be manipulated, by means of an adhesive contact. The gripper arm maneuvers the object to a desired location and the gripper finger releases the object at the desired location. The present invention also relates to a corresponding method.

IPC Classes  ?

• B25J 15/00 - Gripping heads
• B65C 3/00 - Labelling other than flat surfaces
• B65G 47/90 - Devices for picking-up and depositing articles or materials
• B65B 9/00 - Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet materialSubdividing filled flexible tubes to form packages
• B65C 9/08 - Label feeding

Abstract

T>Tgg g g is the glass transition temperature of chalcogenide-glass, and (ii) applying a controlled pressure on the mold to effect penetration to the top surface of the chalcogenide-glass substrate, thereby to replicate the pattern of the mold to the top surface of the substrate; and (C) separating the operational mold from the patterned substrate.

IPC Classes  ?

• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

Abstract

233+ associated with a counter anion, wherein R is saturated or unsaturated hydrocarbyl, which may be the same or different in the uncharged and charged forms, and recovering from the reaction mixture an essentially pure cubic phase of the monochalcogenides.

IPC Classes  ?

• H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
• C01G 19/04 - Halides
• C01G 19/06 - Stannous chloride
• C01B 17/00 - SulfurCompounds thereof
• C01B 19/00 - SeleniumTelluriumCompounds thereof
• H01L 45/00 - Solid state devices specially adapted for rectifying, amplifying, oscillating, or switching without a potential-jump barrier or surface barrier, e.g. dielectric triodes; Ovshinsky-effect devices; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof
• C08K 5/405 - ThioureasDerivatives thereof
• C08K 5/17 - AminesQuaternary ammonium compounds
• C08K 5/01 - Hydrocarbons
• C08K 5/09 - Carboxylic acidsMetal salts thereofAnhydrides thereof

Abstract

The invention relates to a method for creating a space of invisibility, which comprises: (a) providing a metamaterial plate having a subwavelength thickness, said metamaterial plate having bottom and top surfaces; (b) radiating the bottom surface of the metamaterial plate by a primary radiation thereby to form a space of invisibility above the top surface of the metamaterial plate, said space of invisibility being located within a space of a secondary radiation above the metamaterial plate which is in turn formed as a result of said primary radiation passing through metamaterial plate.

IPC Classes  ?

• G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements

Abstract

Disclosed herein are systems and methods of purification of liquid from colloidal particles. More specifically, disclosed are systems and methods for treating water by effecting aggregation of colloidal particles and thus improving their sedimentation, by enhancing grouping of the particles using accelerating, decelerating, and reversing velocity gradients within the liquid. The disclosed methods and systems for water treatment allow for continuous treatment of a contaminated water stream in a single flocculation and sedimentation vessel (i.e. a hybrid process).

IPC Classes  ?

• C02F 1/34 - Treatment of water, waste water, or sewage with mechanical oscillations
• B01D 21/28 - Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
• C02F 1/52 - Treatment of water, waste water, or sewage by flocculation or precipitation of suspended impurities
• B01F 31/65 - Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
• C02F 103/00 - Nature of the water, waste water, sewage or sludge to be treated

Abstract

The invention relates to an input or output facet for an on- chip optical waveguide, the facet comprising a grid of gradually expanding unit-cells such as cones or pyramids.

IPC Classes  ?

• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• H01L 33/22 - Roughened surfaces, e.g. at the interface between epitaxial layers

Abstract

The invention provides a process for preparing an electrode, comprising: electrodeposition of metallic ruthenium/ruthenium oxide (Ru(0)22) coating onto a progressively etched nickel surface; and partial electrochemical oxidation of said metallic ruthenium to ruthenium oxide. The electrode produced and a pseudo-capacitor based on the electrode are also disclosed.

IPC Classes  ?

• H01G 9/055 - Etched foil electrodes
• H01G 4/30 - Stacked capacitors
• H01G 11/26 - Electrodes characterised by their structure, e.g. multi-layered, porosity or surface features
• H01G 11/46 - Metal oxides
• H01M 4/88 - Processes of manufacture
• H01M 4/92 - Metals of platinum group
• C25B 11/04 - ElectrodesManufacture thereof not otherwise provided for characterised by the material
• C25D 5/02 - Electroplating of selected surface areas
• C25D 7/00 - Electroplating characterised by the article coated

Abstract

The present invention relates to antibacterial carbon dots, having aminoguanidine functionality on their outermost surface. The invention further relates to the synthesis of said antibacterial carbon dots, and to the uses of these carbon dots for inhibiting a biofilm formation in the presence of said carbon dots and as fluorescent labeling markers for specific bacteria.

IPC Classes  ?

• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61P 31/04 - Antibacterial agents

Abstract

The invention relates to a method for the preparation of a layer containing a plurality of linear carbyne chains, the method comprising (a) applying laser ablation on a piece of shungite in a liquid, followed by laser irradiation of the resultant carbon structures within the liquid in the presence of stabilizing metal nanoparticles, thereby to form a colloidal solution; and (b) subjecting at least a portion of said colloidal solution to AC voltage while the solution is allowed to dry, thereby to create a two-dimensional layer containing a plurality of carbyne chains.

IPC Classes  ?

• C08G 61/00 - Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
• B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons

Abstract

Methods and compositions for increasing one or more plant growth characteristics in a plant are disclosed. The compositions comprise one or more microbial isolates that promote plant growth. Methods include providing an effective amount of a composition comprising one or more microbial isolates that promote one or more plant growth characteristics.

IPC Classes  ?

• A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
• C05F 11/08 - Organic fertilisers containing added bacterial cultures, mycelia or the like
• C12N 1/20 - BacteriaCulture media therefor

Abstract

The present invention relates to a robot device comprising a chain comprising a plurality of fixedly connected links and a mobile actuator movable thereon configured to change a position of a link relative to a position of an adjacent link; wherein said mobile actuator comprises at least a first motor to drive it along said chain of connected links; and wherein said mobile actuator is engageable with a position-determining element in said link.

IPC Classes  ?

• B25J 9/06 - Programme-controlled manipulators characterised by multi-articulated arms
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 17/00 - Joints
• B25J 18/00 - Arms
• B25J 9/08 - Programme-controlled manipulators characterised by modular constructions

Abstract

2 is in the range of 1:0.5 to 1:0.9, catalytically hydrogenating said carbon monoxide in said hydrogenation reactor, condensing the effluent of said hydrogenation reactor to recover one or more organic liquid(s) and an aqueous solution, feeding a non-condensable component of said effluent into an oligomerization reactor; condensing an effluent discharged from the oligomerization reactor to obtain an additional organic liquid and an additional gaseous stream, separating said additional organic liquid, and either combusting said additional gaseous stream to produce heat and electricity, or processing same to obtain recyclable gaseous streams utilizable in said process.

IPC Classes  ?

• C01B 3/12 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of inorganic compounds containing electro-positively bound hydrogen, e.g. water, acids, bases, ammonia, with inorganic reducing agents by reaction of water vapour with carbon monoxide
• C10G 50/00 - Production of liquid hydrocarbon mixtures from lower carbon number hydrocarbons, e.g. by oligomerisation
• C01B 3/38 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using catalysts
• C01B 3/50 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification
• C10G 2/00 - Production of liquid hydrocarbon mixtures of undefined composition from oxides of carbon
• C10K 3/02 - Modifying the chemical composition of combustible gases containing carbon monoxide to produce an improved fuel, e.g. one of different calorific value, which may be free from carbon monoxide by catalytic treatment
• B01J 37/02 - Impregnation, coating or precipitation
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes
• B01J 35/10 - Solids characterised by their surface properties or porosity
• B01J 23/745 - Iron
• B01J 21/06 - Silicon, titanium, zirconium or hafniumOxides or hydroxides thereof
• C25B 1/00 - Electrolytic production of inorganic compounds or non-metals
• B01J 23/52 - Gold
• C10G 3/00 - Production of liquid hydrocarbon mixtures from oxygen-containing organic materials, e.g. fatty oils, fatty acids
• B01J 37/00 - Processes, in general, for preparing catalystsProcesses, in general, for activation of catalysts
• B01J 23/755 - Nickel
• B01J 37/03 - PrecipitationCo-precipitation
• B01J 21/04 - Alumina

Abstract

in vitroin vitroin vitroin vitro matured sperm obtainable according to the method of the invention and methods of treating subjects in need of mature sperm cells.

IPC Classes  ?

• A61K 35/52 - SpermProstateSeminal fluidLeydig cells of testes
• C12N 5/076 - Sperm cellsSpermatogonia

Abstract

The invention provides a nano-sized particle comprising a cross-linked polymer, wherein the polymer is selected from the group consisting of a polyacrylic acid homopolymer; polymethacrylic acid homopolymer; poly(alkylcyanoacrylate) polymer; a copolymer comprising at least two monomers selected from acrylic acid, methacrylic acid, hydroxyethyl acrylate, hydroxyethyl methacrylate, and alkyl cyanoacrylate/cyanoacrylic acid monomers; carboxymethyl cellulose; alginic acid polymer, polylactic-polyglycolic acid (PLGA), and xanthan gum; and wherein said polymer is cross-linked with a metal ion. A process for preparing such particles is also provided.

IPC Classes  ?

• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 9/51 - Nanocapsules

Abstract

The present invention discloses a novel capacitive vapor sensor comprising porous immobilized graphene oxide (pGO) on an electrode surface. Also disclosed is an in-situ process for the preparation of this sensor and various uses thereof.

IPC Classes  ?

• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• G01N 27/416 - Systems
• G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance

Abstract

A method of estimating potential distribution over a cortical surface of a brain of a subject is disclosed. The method comprises: obtaining encephalogram (EG) data recorded from a scalp surface of the head, and head model data describing a geometry of the head and electrical property distribution of tissues within the head. The method further comprises calculating differentials of the EG data over the scalp surface, calculating volumetric distribution of electrical potential between the cortex and scalp surfaces using the EG data and the differentials, and estimating the potential distribution over the cortical surface based on the volumetric distribution.

IPC Classes  ?

• A61B 5/04 - Measuring bioelectric signals of the body or parts thereof

Abstract

Methods for fabricating three-dimensional objects by 3D-inkjet printing technology, which utilize dicyclopentadiene (DCPD)-based curable materials that polymerize via ring-opening metathesis polymerization (ROMP) for fabricating the object, are provided. Curable formulations and cured materials formed therefrom, containing the dicyclopentadiene (DCPD)-based curable materials are also provided. The dicyclopentadiene (DCPD)-based curable materials and the cured materials formed therefrom are characterized by reduced or nullified malodor.

IPC Classes  ?

• B29C 39/00 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressureApparatus therefor
• C07C 43/18 - Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
• C07C 69/013 - Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
• C07D 233/64 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
• B41J 2/485 - Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by the process of building-up characters applicable to two or more kinds of printing or marking processes
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B32B 25/16 - Layered products essentially comprising natural or synthetic rubber comprising polydienes or poly-halodienes

Abstract

Systems and method for classifying EEG signals of a human subject generated responsive to a series of images containing target images and non-target images. The EEG signals are in a spatio-temporal representation. The time points are classified independently, using a linear discriminant classifier, to compute spatio-temporal discriminating weights that are used to amplify the spatio-temporal representation, to create a spatially-weighted representation. Principal Component Analysis is used on a temporal domain for dimensionality reduction, separately for each spatial channel of the signals, to create a projection, which is applied to the spatially-weighted representation onto a first plurality of principal components, to create a temporally approximated spatially weighted representation. The temporally approximated spatially weighted representation is classified over the channels, using said linear discriminant classifier, to yield a binary decisions series indicative of each image of the images series as either belonging to said target image or to said non-target image.

IPC Classes  ?

• A61B 5/0484 - Electroencephalography using evoked response
• A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
• A61B 5/0476 - Electroencephalography
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Colorimetric and/or fluorescent detectors, which include a polydiacetylene (PDA) film deposited on a polymethylmetacrylate (PMMA) substrate. There are also colorimetric and/or fluorescent detectors which have a solid organic matrix comprising one or more PDAs deposited on the PMMA substrate, wherein the PDA includes polymerized units of one or more diacetylene monomers, and wherein the matrix further comprises at least one recognition element of an analyte. There are also methods for detecting analytes using this detector, uses thereof and a methods for its preparation.

IPC Classes  ?

• G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
• G01N 21/76 - ChemiluminescenceBioluminescence
• C08F 138/00 - Homopolymers of compounds having one or more carbon-to-carbon triple bonds
• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
• B05D 1/00 - Processes for applying liquids or other fluent materials
• B05D 3/06 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
• G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators

Abstract

Disclosed herein are compositions, methods and uses utilizing alginate compositions, for treating, preventing and/or reducing liver damage induced by a hepatotoxic agent, and for treating a medical condition treatable by a hepatotoxic agent, in which an alginate composition is administered prior to, concomitant with, or shortly after exposure to a hepatotoxic agent. Also disclosed are pharmaceutical compositions comprising a hepatotoxic agent and an alginate composition and uses thereof for treating medical conditions treatable by the hepatotoxic agent.

IPC Classes  ?

• A61K 31/734 - Alginic acid
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A gain cell includes a write bit line input, a read bit line output, a write trigger input and a read trigger input. The gain cell also includes a write transistor, retention element and read transistor. Each of the transistors includes a respective first diffusion connection, gate connection and second diffusion connection. The write transistor first diffusion connection is connected to the write bit line input and the write transistor gate connection is connected to the write trigger input. The read transistor first diffusion connection being connected to the read bit line output and the second diffusion connection is connected to the read trigger input. The retention element buffers between write transistor and the read transistor during data retention. The retention element also connects or disconnects a write transistor diffusion connection to/from a constant voltage in accordance with a retained data level at the read transistor gate connection.

IPC Classes  ?

• G11C 7/00 - Arrangements for writing information into, or reading information out from, a digital store

Abstract

A method of pacing a heart of a subject, is disclosed. The heart has a magnetically responsive object therein. The method comprises non-invasively applying to the heart an alternating magnetic field selected to vibrate the object against a wall of the heart such as to effect mechanical stimulation of the heart, thereby pacing the heart.

IPC Classes  ?

• A61H 31/00 - Artificial respiration by a force applied to the chestHeart stimulation, e.g. heart massage

Abstract

An isolated antibody comprising an antigen recognition region which comprises six complementarity determining region (CDR) amino acid sequences as set forth in: (i) SEQ ID NOs: 4, 6, 8, 12, 14 and 16; (ii) SEQ ID NOs: 20, 22, 24, 28, 30 and 32; or (iii) SEQ ID NOs: 36, 38, 40, 44, 46 and 48, is disclosed. Methods of producing same as well as pharmaceutical composition comprising same and uses thereof are disclosed.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

Systems and method for conduction of single trial classification of EEG signals of a human subject generated responsive to a series of images containing target images and non-target images, the method comprising: obtaining said EEG signals in a spatio-temporal representation comprising time points and respective spatial distribution of said EEG signals; classifying said time points independently, using a linear discriminant classifier, to compute spatio-temporal discriminating weights; using said spatio-temporal discriminating weights to amplify said spatio-temporal representation by said spatio-temporal discriminating weights at tempo-spatial points respectively, to create a spatially-weighted representation; using Principal Component Analysis (PCA) on a temporal domain for dimensionality reduction, separately for each spatial channel of said EEG signals, to create a PCA projection; applying said PCA projection to said spatially-weighted representation onto a first plurality of principal components, to create a temporally approximated spatially weighted representation containing for each spatial channel, PCA coefficients for said plurality of principal temporal projections; and classifying said temporally approximated spatially weighted representation, over said number of channels, using said linear discriminant classifier, to yield a binary decisions series indicative of each image of the images series as either belonging to said target image or to said non-target image.

IPC Classes  ?

• A61B 5/316 - Modalities, i.e. specific diagnostic methods
• A61B 5/369 - Electroencephalography [EEG]
• A61B 5/378 - Visual stimuli
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

Systems and method for conduction of single trial classification of EEG signals of a human subject generated responsive to a series of images containing target images and non-target images, the method comprising: obtaining said EEG signals in a spatio-temporal representation comprising time points and respective spatial distribution of said EEG signals; classifying said time points independently, using a linear discriminant classifier, to compute spatio-temporal discriminating weights; using said spatio-temporal discriminating weights to amplify said spatio-temporal representation by said spatio-temporal discriminating weights at tempo-spatial points respectively, to create a spatially-weighted representation; using Principal Component Analysis (PCA) on a temporal domain for dimensionality reduction, separately for each spatial channel of said EEG signals, to create a PCA projection; applying said PCA projection to said spatially-weighted representation onto a first plurality of principal components, to create a temporally approximated spatially weighted representation containing for each spatial channel, PCA coefficients for said plurality of principal temporal projections; and classifying said temporally approximated spatially weighted representation, over said number of channels, using said linear discriminant classifier, to yield a binary decisions series indicative of each image of the images series as either belonging to said target image or to said non-target image.

IPC Classes  ?

• A61B 5/04 - Measuring bioelectric signals of the body or parts thereof
• A61B 5/0476 - Electroencephalography
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)

Abstract

Disclosed herein are compositions, methods and uses utilizing alginate compositions, for treating, preventing and/or reducing liver damage induced by a hepatotoxic agent, and for treating a medical condition treatable by a hepatotoxic agent, in which an alginate composition is administered prior to, concomitant with, or shortly after exposure to a hepatotoxic agent. Also disclosed are pharmaceutical compositions comprising a hepatotoxic agent and an alginate composition and uses thereof for treating medical conditions treatable by the hepatotoxic agent.

IPC Classes  ?

• A61K 31/734 - Alginic acid
• A61K 31/738 - Cross-linked polysaccharides
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

Compositions comprising an alginate, a source of sodium ions and a carrier (e.g., a pharmaceutically acceptable carrier), which are characterized by reduced association of the alginate chains and hence by at least one of: (i) a zeta potential weaker than -25 mV, at a concentration of 0.5 % (w/v) alginate in the carrier; and (ii) a diffusion coefficient of at least 10-8 cm2/millisecond, at a concentration of 0.5 % (w/v) alginate in the carrier, are disclosed. Also disclosed are uses of the composition and methods utilizing the composition for treating inflammatory bowel disease, liver damage, diseases and disorders, for treating a medical condition treatable by a hepatotoxic agent and for reducing or preventing liver damage, including liver damage caused by a hepatotoxic agent.

IPC Classes  ?

• A61K 31/734 - Alginic acid
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

A method for designing a dual-mode logic circuit which is selectably operational in static and dynamic modes is performed as follows. A basis library with a DML inverter and dual-mode logic (DML) bicells is provided. Each DML bicell includes a type-A DML logic gate with a clock input and a type-B DML logic gate with an inverted clock input. A pseudo-static library is formed from the basis library by modifying each bicell of the basis library and specifying at least one dynamic timing parameter. A dynamic library is formed from the basis library by specifying dynamic timing parameters for the basis library DML inverter and bicells. Logic behavior of the required logic circuit is defined. An initial logic circuit design synthesized from the pseudo-static library and the defined logic behavior. Finally, a dynamic circuit design is formed by replacing modified bicells with corresponding bicells from the dynamic library.

IPC Classes  ?

• H03K 19/00 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits