Abstract

The present invention relates to a composition for use in FDM 3D printers, the composition comprising bioglass and a biocompatible polymer resin. In addition, the present invention relates to a molded article produced by an FDM 3D printer, the molded article having a structure in which the composition for use in FDM 3D printers is injection-molded into struts laminated in four layers. Further, the present invention relates to a method for producing the composition for use in FDM 3D printers, the method comprising the steps of: (1) sintering bioglass; (2) mixing the sintered bioglass with a biocompatible polymer resin to prepare a composition; (3) feeding the composition into a freezer mill to pulverize the composition; and (4) melting the pulverized composition. The present invention advantageously solves the problem of brittleness inherent in medical/biological molded articles produced by FDM 3D printers, and thus can provide molded articles having excellent toughness and biocompatibility.

IPC Classes  ?

• C08K 3/40 - Glass
• C08L 101/00 - Compositions of unspecified macromolecular compounds
• B32B 27/18 - Layered products essentially comprising synthetic resin characterised by the use of special additives
• B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
• B33Y 80/00 - Products made by additive manufacturing

Abstract

A composition for a FDM 3D printer is disclosed. The composition contains bioglass and a biocompatible polymer resin. In addition, a FDM 3D printer molded article having a laminated strut structure, in which the composition for the FDM 3D printer is injected into four layers, is disclosed.

IPC Classes  ?

• C04B 35/22 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on silicates other than clay rich in calcium oxide
• B28B 1/00 - Producing shaped articles from the material
• C04B 35/634 - Polymers
• C04B 35/64 - Burning or sintering processes
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials

Abstract

Disclosed is a scaffold for a living donor transplantation with physical properties improved by using a 3D printer that uses a fused deposition modeling method and includes sintered bioglass and a biocompatible polymer.

IPC Classes  ?

• A61L 27/56 - Porous or cellular materials
• A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
• A61L 27/10 - Ceramics or glasses
• B29C 64/10 - Processes of additive manufacturing
• B29C 45/00 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mouldApparatus therefor
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing

Abstract

22, and a binder solution. By injecting the composition for FDM 3D printers in the form of a paste into a FDM 3D printer, a molded product can be quickly manufactured without a melting process, and various geometric structures can be precisely implemented. Therefore, the composition can be utilized as a biological body substitute for medical use.

IPC Classes  ?

• C04B 35/03 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on magnesium oxide, calcium oxide or oxide mixtures derived from dolomite
• C04B 35/636 - Polysaccharides or derivatives thereof
• C04B 35/64 - Burning or sintering processes
• B28B 1/00 - Producing shaped articles from the material
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing

Abstract

The present invention relates to a collagen membrane and a manufacturing method thereof, and particularly, to a collagen membrane for treating periodontal tissues by easy surgical procedure, by optimizing the appropriate concentrations of collagen and a crosslinking agent to provide high tensile strength in short decomposition time, and a manufacturing method thereof.

IPC Classes  ?

• A61L 27/56 - Porous or cellular materials

Abstract

The present invention relates to a stent comprising: a metal stent; a titanium oxide layer coated on the metal stent; and a material layer coated on the titanium oxide layer.

IPC Classes  ?

• A61L 31/18 - Materials at least partially X-ray or laser opaque
• A61L 31/08 - Materials for coatings
• A61L 31/02 - Inorganic materials
• A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

Abstract

Provided are granule aggregate for a substituting bone and a manufacturing method thereof. More particularly, provided are granule aggregate for a substituting bone which optimizes the composition of a calcium phosphate compound and collagen in order to prevent a substituting bone from being falling into small pieces even when constant shear force is applied, thereby facilitating the supply of the substituting bone to a bone defect portion or a tooth extraction portion both of which require filling, and a manufacturing method thereof.

IPC Classes  ?

• A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61F 2/46 - Special tools for implanting artificial joints
• A61M 5/178 - Syringes
• A61F 2/28 - Bones

Abstract

A bone substitute implant is provided. A bone substitute implant according to an embodiment of the present invention comprises: a synostosis member which comprises a body made of a bioactive crystallized glass material, and which contacts the surface of an adjacent bone so as to fuse therewith; an implant body to be retained between adjacent bones; and a buffer member arranged between the synostosis member and the implant body such that the synostosis member and the implant body are spaced from each other.

IPC Classes  ?

• A61F 2/44 - Joints for the spine, e.g. vertebrae, spinal discs
• A61B 17/70 - Spinal positioners or stabilisers, e.g. stabilisers comprising fluid filler in an implant
• A61L 27/10 - Ceramics or glasses
• A61L 27/06 - Titanium or titanium alloys
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/14 - Macromolecular materials
• A61F 2/30 - Joints

Abstract

The present invention relates to a medical catheter apparatus comprising an injection tube, a first balloon catheter and a second balloon catheter, wherein the first balloon catheter and the second balloon catheter are disposed in order on the injection tube. The medical catheter apparatus can comprise a third balloon catheter or a stent.

IPC Classes  ?

• A61M 25/10 - Balloon catheters
• A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters

Abstract

The present invention relates to a method of producing a medical material for replacing lost portions of hard tissue, and a medical material produced through same and, more particularly, provides a medical material by pressure forming a bioactive glass powder, then conducting a first heat treatment at a relatively low temperature lower than the glass transition temperature of the bioactive glass, and then processing into a desired shape and conducting a second heat treatment at a temperature higher than the glass transition temperature of the bioactive glass, in order to overcome the low compression strength drawback of hydroxyapatite, which is used as an existing hard tissue replacement material, while enabling the custom production of a desired shape that fits the shape of a lost portion of hard tissue in vivo, minimizing thermal shock, and being able to exhibit bone fusion properties as well.

IPC Classes  ?

• C03B 19/06 - Other methods of shaping glass by sintering
• A61F 2/28 - Bones
• A61F 2/30 - Joints
• A61C 13/08 - Artificial teethMaking same

Abstract

The present application relates to a biodegradable magnesium stent of which the in vivo biodegradation rate is controlled, and a preparation method therefor.

IPC Classes  ?

• A61L 27/04 - Metals or alloys
• A61L 27/34 - Macromolecular materials

Abstract

The present invention relates to a bioabsorbable radiopaque marker composition and a surgical article comprising the same. The bioabsorbable radiopaque marker composition according to the present invention comprises iodine, xenon, or a combination thereof. If the surgical article according to the present invention is used, it is possible to accurately trace and observe the position of a stent, etc. within the human body.

IPC Classes  ?

• A61L 31/18 - Materials at least partially X-ray or laser opaque
• A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• A61L 27/56 - Porous or cellular materials
• A61L 17/14 - Post-treatment to improve physical properties
• A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)

Abstract

The present invention relates to a system for producing artificial osseous tissue and a method for producing same. The system for producing artificial osseous tissue, according to one embodiment of the present invention, may comprise: a client computer which obtains three-dimensional image information of osseous tissue, of a patient, that is being subjected to surgery from a photographing unit photographing the osseous tissue that is being subjected to surgery and generating the image information, and which connects to a network for transmitting the image information, and which comprises a user interface for outputting user input or information; a server computer which identifies the osseous tissue that is being subjected to surgery on the basis of the image information of the osseous tissue that is being subjected to surgery received from the client computer, and which generates at least one or more three-dimensional image information of a osseous tissue model for treatment corresponding to the osseous tissue that is being subjected to surgery, and which transmits, to the client computer, the at least one or more three-dimensional image information of the osseous tissue model for treatment so that the client computer verifies and confirms the at least one or more image information of the osseous tissue model for treatment; and a manufacturing unit which produces an artificial osseous tissue on the basis of the three-dimensional image information of the osseous tissue model for treatment confirmed by the server computer.

IPC Classes  ?

• A61F 2/28 - Bones
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
• A61F 2/30 - Joints

Abstract

The present invention relates to a crystallized glass ceramic comprising 30 to 40 % by weight of each of CaSiO3, Ca10(PO4)6(OH)2 and Ca2Mg(Si2O7), a crystallized glass ceramic composition comprising CaSiO3, Ca10(PO4)6(OH)2 and Ca2Mg(Si2O7) in a predetermined weight ratio, a bone graft material comprising the glass ceramic, and a medical device for replacement of osseous tissue, or an intervertebral spacer, which is manufactured using the bone graft material.

IPC Classes  ?

• C03C 10/06 - Divalent metal oxide aluminosilicate crystalline phase, e.g. anorthite, slagcerams
• C03C 10/00 - Devitrified glass ceramics, i.e. glass ceramics having a crystalline phase dispersed in a glassy phase and constituting at least 50% by weight of the total composition

Abstract

The present invention relates to a bone graft composition and a preparation method thereof, and more particularly to a bone graft composition, which is in the form of a porous scaffold comprising calcium phosphate compound particles, silk fibroin and poloxamer in a certain mixed ratio, and a preparation method thereof. Since the bone graft composition of the present invention can be changed into various shapes in a wet state and has an excellent ability to restore its original shape, it can be conveniently implanted and densely filled in bone defects.

IPC Classes  ?

• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
• A61L 27/22 - Polypeptides or derivatives thereof
• A61F 2/28 - Bones

Abstract

The present invention relates to a bone graft composition and a preparation method thereof, and more particularly to a bone graft composition having excellent physical properties, which comprises a hydrogel comprising a combination of specific amounts of poloxamer and HPMC, and calcium phosphate compound particles, and a preparation method thereof.

IPC Classes  ?

• A61L 27/02 - Inorganic materials
• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/14 - Macromolecular materials
• A61F 2/28 - Bones