Abstract

An optical fiber (4) is proposed comprising: an outer cladding section surrounding an inner core section, the outer cladding sec- tion having a refractive index lower than the refractive index of the core section and the outer cladding section and the core section forming an optical light guide; an emission area (8) associated with one emission end (3) of the optical fiber (2), the emission area (8) extending in a longitudinal direction along the optical fiber (4) and being arranged for emitting radiation in a lateral direction with respect to the longitudinal direction of the optical fiber (4); wherein within the emission area (8), the core section is provided with a plurality of scattering sites (100), which are each formed by a local variation of the refractive index in the core section.

IPC Classes  ?

• F21V 8/00 - Use of light guides, e.g. fibre optic devices, in lighting devices or systems
• G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers
• G02B 6/02 - Optical fibres with cladding

Goods & Services

Medical apparatus and instruments for treating alzheimer's disease, cancer and pre-cancerous tissues and conditions; veterinary apparatus, namely, lasers for medical purposes and lasers for photodynamic therapy; lasers for use in surgery; lasers for skin treatment. Medical treatment of alzheimer's disease, cancer and pre-cancerous conditions using photodynamic therapy; health care services for treating alzheimer's disease; providing laser therapy for treating medical conditions; human hygiene and beauty care; hygienic and beauty care for animals.

Abstract

Biologically active compounds and their methods of preparation are provided that may be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of non-tumorous indications such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, otorhinolaryngology disorders, ophthalmological or urological disorders. As the compounds exhibit also toxicity against targets (tumor cells, bacteria inflammation-related cells) without light these biologically active compounds may also be used for the light-independent treatment of such indications. Embodiments also include methods to synthesize iridium(III) complex structures incorporating a substituted 2,3,5,6-tetrafluorophenyl-dipyrromethene (2,3,5,6-tetratfluorophenyldipyrrin) unit or a substituted 3-nitrophenyl-dipyrromethene (3-nitrophenyl-dipyrrin) unit. Amphiphilic compounds with increased anti-tumour and anti-bacterial efficacy are also provided. Specifically, this is achieved by substitution with bromine atoms and sugar moieties.

IPC Classes  ?

• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61P 31/04 - Antibacterial agents
• A61P 35/00 - Antineoplastic agents
• C07F 17/02 - Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table

Abstract

The production and new type of preforms are presented which yield, upon drawing, new, class of optical fibers, improved, speckle-free output optical fibers. Useful fibers, providing speckle-free, smooth output with flat top transmission of light from gaussian or few mode sources are produced from preforms introduced herein. The unique production of these improved preforms is also presented. The preforms, and thus the fibers produced in varying core dimensions from about 100 μm to above 1000 μm, are based on a structured silica section of mode mixing area adjacent to the inner core, or in the case of non-circular core, within the core. Plasma Vapor Deposition process is modified to achieve the structured sections in a well-controlled manner. The structured sections are composed of a number of pairs of layers, where a thin down-doped layer is alternated with a much thicker core material layer. The ratio of the thickness of the core layer to the thickness of the down-doped layer is about 3 to 25. The number of paired layers is typically between about 8 to 30-layer pairs. The effective NA of the structured section is dependent on the particulars of the structured silica section and of the individual down-doped layer. Both circular inner core examples and non-circular core examples are possible and are discussed, herein.

IPC Classes  ?

• G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers
• G02B 6/14 - Mode converters
• C03B 37/014 - Manufacture of preforms for drawing fibres or filaments made entirely or partially by chemical means

Abstract

A new type of all-silica optical fiber is described; a Structured Silica Clad Silica (SSCS) optical fiber, whose cladding is structured to provide mode mixing within the core; and/or to have an average effective refractive index. Its cross-section is essentially symmetrical, it can be used, among other objects, to provide flatter, more speckle-free outputs from fiber lasers, or other limited mode photonic sources. Building the new fiber structure around a rare earth doped laser core provides a better fiber laser/amplifier for cladding pumping. The structured silica cladding contains paired layers, in which a down doped silica layer is followed by a layer of pure, or lesser down-doped, or even up-dope silica, and die number of paired layers is, typically, from 5 to about 25, and, generally, within the paired layers the ratio of thickness of the higher RI layer of silicate the down-doped silica is very broad, lying between about 0.0625 to about 16, depending on the intended use of the SSCS fibers. In some versions, the main core material can be up-doped silica with pure silica or down-doped silica as the primary second component.

IPC Classes  ?

• H01S 3/067 - Fibre lasers
• H01S 3/17 - Solid materials amorphous, e.g. glass
• C03B 37/027 - Fibres composed of different sorts of glass, e.g. fibre optics

Abstract

Biologically active compounds and their methods of preparation are provided that may be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of non-tumorous indications such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, otorhinolaryngology disorders, ophthalmological or urological disorders. As the compounds exhibit also toxicity against targets (tumor cells, bacteria, inflammation-related cells) without light these biologically active compounds may also be used for the light-independent treatment of such indications. Embodiments also include methods to synthesize boron dipyrromethene complex structures incorporating a substituted 2,3,5,6-tetrafluorophenyl-dipyrromethene (2,3,5,6-tetrafluorophenyldipyrrin) unit or a substituted 3-nitrophenyl-dipyrromethene (3-nitrophenyl-dipyrrin) unit. Amphiphilic compounds with increased anti-tumour and anti-bacterial efficacy are also provided. Specifically, this is achieved by substitution with bromine atoms and sugar moieties.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 31/69 - Boron compounds
• A61P 35/00 - Antineoplastic agents

Abstract

Biologically active compounds are provided that may be used as photosensitizers for diagnostic and therapeutic applications, particularly for phototherapy, including photodynamic therapy, of viral or bacterial infections. As the compounds exhibit also toxicity against targets (bacteria, viruses) without light these biologically active compounds may also be used for the light- independent treatment of such diseases. Embodiments include porphyrins, chlorins, and dihydroxy chlorins as well as their zinc complexes. Also included are embodiments where these compounds are incorporated into liposomal formulations.

IPC Classes  ?

• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
• A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
• A61P 31/04 - Antibacterial agents
• A61P 31/12 - Antivirals

Abstract

Biologically active compounds and their methods of preparation are provided that may be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of non-tumorous indications such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, otorhinolaryngology disorders, ophthalmological or urological disorders. As the compounds exhibit also toxicity against targets (tumor cells, bacteria, inflammation-related cells) without light these biologically active compounds may also be used for the light-independent treatment of such indications. Embodiments also include methods to synthesize iridium(III) complex structures incorporating a substituted 2,3,5,6-tetrafluorophenyl-dipyrromethene (2,3,5,6- tetrafluorophenyldipyrrin) unit or a substituted 3-nitrophenyl-dipyrromethene (3- nitrophenyl-dipyrrin) unit. Amphiphilic compounds with increased anti-tumour and anti- bacterial efficacy are also provided. Specifically, this is achieved by substitution with bromine atoms and sugar moieties.

IPC Classes  ?

• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 35/00 - Antineoplastic agents
• C07F 17/02 - Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
• A61P 31/04 - Antibacterial agents

Abstract

The present invention provides certain tetrapyrrolic compounds having a structure of Formula (1), (2), or (3) wherein B is (I), (II) (III) or (IV), O—R1 is a substituent in the meta or para position of the phenyl ring, R1 is a glyco-substituent derived from a mono-, di-, or trisaccharide group, and each R2 is independently selected from the group consisting of a linear or branched (fluoro-)alkyl group with 3 to 8 carbon atoms, phenyl, pentafluorophenyl, 3,5-bis(trifluoromethyl)phenyl, 4-(1′-thio-β-D-glucosyl)-2,3,5,6-tetrafluorophenyl, 4-(1′-thio-β-D-galactosyl)-2,3,5,6-tetrafluorophenyl, meta- or para-hydroxyphenyl, meta- or para-carboxyphenyl, and meta- or para-YO-phenyl with Y being a polyethyleneglycol-residue with (CH2CH2O)nCH3 with n=1-30. The present invention provides certain tetrapyrrolic compounds having a structure of Formula (1), (2), or (3) wherein B is (I), (II) (III) or (IV), O—R1 is a substituent in the meta or para position of the phenyl ring, R1 is a glyco-substituent derived from a mono-, di-, or trisaccharide group, and each R2 is independently selected from the group consisting of a linear or branched (fluoro-)alkyl group with 3 to 8 carbon atoms, phenyl, pentafluorophenyl, 3,5-bis(trifluoromethyl)phenyl, 4-(1′-thio-β-D-glucosyl)-2,3,5,6-tetrafluorophenyl, 4-(1′-thio-β-D-galactosyl)-2,3,5,6-tetrafluorophenyl, meta- or para-hydroxyphenyl, meta- or para-carboxyphenyl, and meta- or para-YO-phenyl with Y being a polyethyleneglycol-residue with (CH2CH2O)nCH3 with n=1-30.

IPC Classes  ?

• C09B 47/00 - PorphinesAzaporphines
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 51/04 - Organic compounds

Abstract

The production and new type of preforms are presented which yield, upon drawing, new, class of optical fibers, improved, speckle-free output optical fibers. Useful fibers, providing speckle-free, smooth output with flat top transmission of light from gaussian or few mode sources are produced from preforms introduced herein. The unique production of these improved preforms is also presented. The preforms, and thus the fibers produced in varying core dimensions from about 100µm to above 1000µm, are based on a structured silica section of mode mixing area adjacent to the inner core, or in the case of non-circular core, within the core. Plasma Vapor Deposition process is modified to achieve the structured sections in a well-controlled manner. The structured sections are composed of a number of pairs of layers, where a thin down-doped layer is alternated with a much thicker core material layer. The ratio of the thickness of the core layer to the thickness of the down-doped layer is about 3 to 25. The number of paired layers is typically between about 8 to 30-layer pairs. The effective NA of the structured section is dependent on the particulars of the structured silica section and of the individual down-doped layer. Both circular inner core examples and non-circular core examples are possible and are discussed, herein.

IPC Classes  ?

• C03B 37/012 - Manufacture of preforms for drawing fibres or filaments
• C03B 37/014 - Manufacture of preforms for drawing fibres or filaments made entirely or partially by chemical means
• G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers
• G02B 6/14 - Mode converters

Abstract

A new type of all-silica optical fiber is described; a Structured Silica Clad Silica (SSCS) optical fiber, whose cladding is structured to provide mode mixing within the core; and/or to have an average effective refractive index. Its cross-section is essentially symmetrical, it can be used, among other objects, to provide flatter, more speckle-free outputs from fiber lasers, or other limited mode photonic sources. Building the new fiber structure around a rare earth doped laser core provides a better fiber laser/amplifier for cladding pumping. The structured silica cladding contains paired layers, in which a down doped silica layer is followed by a layer of pure, or lesser down-doped, or even up-dope silica, and die number of paired layers is, typically, from 5 to about 25, and, generally, within the paired layers the ratio of thickness of the higher RI layer of silicate the down-doped silica is very broad, lying between about 0.0625 to about 16, depending on the intended use of the SSCS fibers. In some versions, the main core material can be up-doped silica with pure silica or down-doped silica as the primary second component.

IPC Classes  ?

• C03B 37/012 - Manufacture of preforms for drawing fibres or filaments
• C03B 37/014 - Manufacture of preforms for drawing fibres or filaments made entirely or partially by chemical means
• G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers
• G02B 6/14 - Mode converters

Abstract

The production and new type of preforms are presented which yield, upon drawing, new, class of optical fibers, improved, speckle-free output optical fibers. Useful fibers, providing speckle-free, smooth output with flat top transmission of light from gaussian or few mode sources are produced from preforms introduced herein. The unique production of these improved preforms is also presented. The preforms, and thus the fibers produced in varying core dimensions from about 100µm to above 1000µm, are based on a structured silica section of mode mixing area adjacent to the inner core, or in the case of non-circular core, within the core. Plasma Vapor Deposition process is modified to achieve the structured sections in a well-controlled manner. The structured sections are composed of a number of pairs of layers, where a thin down-doped layer is alternated with a much thicker core material layer. The ratio of the thickness of the core layer to the thickness of the down-doped layer is about 3 to 25. The number of paired layers is typically between about 8 to 30-layer pairs. The effective NA of the structured section is dependent on the particulars of the structured silica section and of the individual down-doped layer. Both circular inner core examples and non-circular core examples are possible and are discussed, herein.

IPC Classes  ?

• C03B 37/012 - Manufacture of preforms for drawing fibres or filaments
• C03B 37/014 - Manufacture of preforms for drawing fibres or filaments made entirely or partially by chemical means
• G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers
• G02B 6/14 - Mode converters

Abstract

A new type of all-silica optical fiber is described; a Structured Silica Clad Silica (SSCS) optical fiber, whose cladding is structured to provide mode mixing within the core; and/or to have an average effective refractive index. Its cross-section is essentially symmetrical, it can be used, among other objects, to provide flatter, more speckle-free outputs from fiber lasers, or other limited mode photonic sources. Building the new fiber structure around a rare earth doped laser core provides a better fiber laser/amplifier for cladding pumping. The structured silica cladding contains paired layers, in which a down doped silica layer is followed by a layer of pure, or lesser down-doped, or even up-dope silica, and die number of paired layers is, typically, from 5 to about 25, and, generally, within the paired layers the ratio of thickness of the higher RI layer of silicate the down-doped silica is very broad, lying between about 0.0625 to about 16, depending on the intended use of the SSCS fibers. In some versions, the main core material can be up-doped silica with pure silica or down-doped silica as the primary second component.

IPC Classes  ?

• C03B 37/012 - Manufacture of preforms for drawing fibres or filaments
• C03B 37/014 - Manufacture of preforms for drawing fibres or filaments made entirely or partially by chemical means
• G02B 6/036 - Optical fibres with cladding core or cladding comprising multiple layers
• G02B 6/14 - Mode converters

Abstract

Biologically active compounds and their methods of preparation are provided that may be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of non-tumorous indications such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, otorhinolaryngology disorders, ophthalmological or urological disorders. As the compounds exhibit also toxicity against targets (tumor cells, bacteria, inflammation-related cells) without light these biologically active compounds may also be used for the light-independent treatment of such indications. Embodiments also include methods to synthesize boron dipyrromethene complex structures incorporating a substituted 2,3,5,6-tetrafluorophenyl-dipyrromethene (2,3,5,6-tetrafluorophenyldipyrrin) unit or a substituted 3-nitrophenyl-dipyrromethene (3-nitrophenyl-dipyrrin) unit. Amphiphilic compounds with increased anti-tumor and anti-bacterial efficacy are also provided. Specifically, this is achieved by substitution with bromine atoms and sugar moieties.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• A61K 47/66 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
• A61K 31/69 - Boron compounds
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 31/04 - Antibacterial agents
• A61P 35/00 - Antineoplastic agents
• C07H 23/00 - Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Abstract

Biologically active compounds and their methods of preparation are provided that may be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of non-tumorous indications such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, otorhinolaryngology disorders, ophthalmological or urological disorders. As the compounds exhibit also toxicity against targets (tumor cells, bacteria, inflammation-related cells) without light these biologically active compounds may also be used for the light-independent treatment of such indications. Embodiments also include methods to synthesize boron dipyrromethene complex structures incorporating a substituted 2,3,5,6-tetrafluorophenyl-dipyrromethene (2,3,5,6-tetrafluorophenyldipyrrin) unit or a substituted 3-nitrophenyl-dipyrromethene (3-nitrophenyl-dipyrrin) unit. Amphiphilic compounds with increased anti-tumor and anti-bacterial efficacy are also provided. Specifically, this is achieved by substitution with bromine atoms and sugar moieties.

IPC Classes  ?

• C07F 5/02 - Boron compounds
• C07H 23/00 - Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
• A61K 31/69 - Boron compounds
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention provides certain tetrapyrrolic compounds having a structure of Formula (1), (2), or (3) wherein B is (I), (II) (III) or (IV), O-R1metaparapara position of the phenyl ring, R1is a glyco-substituent derived from a mono-, di-, or trisaccharide group, and each R2metaparametaparametapara22n33 with n = 1-30.

IPC Classes  ?

• C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings
• C09B 47/00 - PorphinesAzaporphines
• A61P 35/00 - Antineoplastic agents
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
• A61P 13/00 - Drugs for disorders of the urinary system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 17/00 - Drugs for dermatological disorders
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 27/02 - Ophthalmic agents

Abstract

The present invention provides biologically active compounds and methods to obtain biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of non-tumorous indications such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders. As the compounds exhibit also toxicity against targets (tumor cells, bacteria, inflammation-related cells) without light these biologically active compounds may also be used for the light-independent treatment of such indications. Preferred embodiments of the present invention consist of methods to synthesize metal or half-metal complex structures incorporating one or more substituted 2,3,5,6-tetrafluorophenyl-dipyrromethene (2,3,5,6-tetrafluorophenyldipyrrin) units. These dipyrromethenes (dipyrrins) can carry a variety of different substituents in the 4-position enabling a fine tuning of their biological or amphiphilic/hydrophilic properties. Another object of the present invention is to provide amphiphilic compounds with a higher membrane affinity and increased efficacy.

IPC Classes  ?

• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
• C07F 15/06 - Cobalt compounds
• C07F 15/02 - Iron compounds
• C07F 15/04 - Nickel compounds
• C07F 1/08 - Copper compounds
• C07F 3/06 - Zinc compounds
• C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
• C07F 19/00 - Metal compounds according to more than one of main groups
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61P 35/00 - Antineoplastic agents
• A61P 31/04 - Antibacterial agents
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• C07F 1/00 - Compounds containing elements of Groups 1 or 11 of the Periodic Table
• A61K 49/00 - Preparations for testing in vivo
• C07F 3/00 - Compounds containing elements of Groups 2 or 12 of the Periodic Table
• A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol

Abstract

A fiber optic light source in which input light with short and narrow band wavelength is converted/transformed into multi-band visible white light with high intensity output power is provided. The new light source comprises at least one homogenizing light guide element, and at least one photoluminescence element. It may also comprise at least one input element and an optical fiber. All or some of the elements may be integrated into an optical waveguide. In some embodiments, the at least one input element increases light transfer efficiency from a ray source to the at least one homogenizing light guide element component of the fiber optic light source. The at least one photoluminescence element can be a point or an extended form like a line or surface. The fiber optic light source output beam may also contain the input ray wavelength, which in turn can be from a fiber optic laser. In operation, an input ray travels through at least one homogenizing light guide element and irradiates at least one photoluminescence element present in preselected positions of the device to cause large area or spacious illumination at a desired target. This source can be an information source to communicate information through light modulation not noticeable to the naked human eye. Information is sent from the optical light source to information receivers, technical devices like smart phones, TV-Displays, or other devices, which could replace the common use of LAN or WLAN networks. Here a known luminescent detector can be used to efficiently collect the information in its optical form and to lead it to a suitable photo detector. This enables free-space optical light information transfer especially in areas where traditional infrastructure using transmitting fibers is difficult to establish.

IPC Classes  ?

• F21K 9/64 - Optical arrangements integrated in the light source, e.g. for improving the colour rendering index or the light extraction using wavelength conversion means distinct or spaced from the light-generating element, e.g. a remote phosphor layer
• F21V 8/00 - Use of light guides, e.g. fibre optic devices, in lighting devices or systems
• G02B 6/02 - Optical fibres with cladding
• G02B 6/42 - Coupling light guides with opto-electronic elements
• H04B 10/114 - Indoor or close-range type systems
• H04B 10/116 - Visible light communication
• H01S 3/067 - Fibre lasers
• G02B 27/09 - Beam shaping, e.g. changing the cross-sectioned area, not otherwise provided for

Abstract

Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, opthamological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. One embodiment consists of a method to synthesize a porphyrin with a defined arrangement of meso-substituents and then converting this porphyrin system to a chlorin system by dihydroxylation or reduction, and if more than one isomer is formed separate them by chromatography either on normal or reversed phase silica. In another embodiment the substituents on the porphyrin are selected to direct the reduction or dihydroxylation to the chlorin so that a certain isomer is selectively formed. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT-efficacy. In other embodiments the nucleophilic substitution on pentafluorophenyl-substituted tetrapyrroles is used to obtain compounds with a high PDT-efficacy. In another embodiment substituents are identified that via their steric and/or electronic influence direct the dihydroxylation or reduction with diimine so that one isomer is favored. Another embodiment consists of formulating the desired tetrapyrrole photosensitizer into a pharmaceutical formulation to be injected into the body avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.

IPC Classes  ?

• C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/409 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
• C07F 5/02 - Boron compounds
• A61K 31/03 - Halogenated hydrocarbons carbocyclic aromatic

Abstract

Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. In addition, conjugates are provided in which these photosensitizers are attached to water-soluble polymers via cleavable linkers that can be cleaved in the body under specific conditions. Another embodiment consists of formulating the desired tetrapyrrole photosensitizer into a pharmaceutical formulation to be injected into the body avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.

IPC Classes  ?

• A01N 43/38 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• C08G 65/48 - Polymers modified by chemical after-treatment

Goods & Services

optical fiber system comprised of lasers, optical fibers, related delivery accessories such as probes and hand pieces, and parts and accessories therefore, for use in medical and surgical treatments; optical fibers for surgical treatments; optical fiber kit, for use in medical and surgical treatments comprising optical fiber and parts and accessories therefor, all for medical use

Abstract

Medical systems, comprising at least one electromagnetic radiation emitting device for medical applications, at least one mobile electronic device, and at least one attachable/detachable transmission medium, are provided. The electromagnetic radiation 5 emitting device comprises a radiation source such as a laser source, a radiofrequency source, or a microwave source and required safety features/controls. The mobile electronic device has advanced computing capability and connectivity, and is capable of wirelessly accessing a network, such as a smart phone, a tablet personal computer, and alike. The transmission mediums are optical fibers, handpieces, fiber-optic systems, 10 radiofrequency catheters and electrodes, microwave transmission media, having differently shaped distal tips, differently shaped support tubes, and lens assemblies with different focal distances. This makes system versatile, as it can be easily adapted to a large number of diverse medical applications.

IPC Classes  ?

• A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
• A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, opthamological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. One embodiment consists of a method to synthesize a porphyrin with a defined arrangement of meso-substituents and then converting this porphyrin system to a chlorin system by dihydroxylation or reduction, and if more than one isomer is formed separate them by chromatography either on normal or reversed phase silica. In another embodiment the substituents on the porphyrin are selected to direct the reduction or dihydroxylation to the chlorin so that a certain isomer is selectively formed. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT-efficacy. In other embodiments the nucleophilic substitution on pentafluorophenyl-substituted tetrapyrroles is used to obtain compounds with a high PDT-efficacy. In another embodiment substituents are identified that via their steric and/or electronic influence direct the dihydroxylation or reduction with diimine so that one isomer is favored. Another embodiment consists of formulating the desired tetrapyrrole photosensitizer into a pharmaceutical formulation to be injected into the body avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.

IPC Classes  ?

• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
• C07F 5/02 - Boron compounds
• A61K 31/409 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
• A61P 35/00 - Antineoplastic agents

Abstract

Improved, efficient devices/methods for medical and cosmetic applications, involving the delivery of laser energy to tissue are provided. In a preferred embodiment a portable, easy-to-use laser system comprises at least one laser source operating at one or more laser wavelengths; an electronic visual display having a n-dimensional input interface to set/select laser parameters; and at least one waveguide optically coupled to the laser source to convey laser radiation to a treatment site. The n-dimensional input interface inputs/selects lasing parameters which allows the selection of a combination of output wavelengths and powers by simply touching the electronic visual display. Method of use comprises the steps of placing at least one waveguide at preselected treatment site; selecting a combination of laser wavelengths and power by interacting with an electronic visual display; and irradiating the treatment site.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
• A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61N 5/067 - Radiation therapy using light using laser light
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

A device and method for treating a vagina's anatomic, functional and aesthetic conditions are disclosed. Device comprises a laser energy source which conveys laser energy through an optical fiber handpiece. A cylindrical/penis shaped device/applicator is specially designed for safe and accurate irradiation of determined parts of vaginal mucosa. Applicator has an inner hollow path through which optical fiber is inserted to irradiate interior vaginal tissue. Irradiated mucous tissue contracts, reducing vaginal radius and during penetration in sexual intercourse it embraces penis more tightly. Sensitivity is substantially improved and sexual intercourse is more pleasurable for both partners. In one embodiment, a 1470 nm diode laser source is used. In another embodiment, a vagina's outer dimensions are accurately measured and surgery is performed to achieve dimensions according to certain aesthetic and functional criteria. Minimum pain and risk of side effects are experienced with this ambulatory procedure performable in a physician's office.

IPC Classes  ?

• A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
• A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body

Goods & Services

Optical fiber system and parts and accessories therefor, for use in medical and surgical treatments; optical fibers for surgical treatments; optical fiber kit, for use in medical and surgical treatments comprising optical fiber and parts and accessories therefor, laser systems primarily using said optical fiber systems, all for medical use.

Goods & Services

Energy emitting systems, namely optical and laser-powered systems for use in cosmetic and aesthetic treatments; energy emitting systems comprising primarily laser sources, sensing/control devices and disposable or reusable attachments, especially ones based on fiber optics and manipulation elements, parts and accessories therefor, all for cosmetic and aesthetic treatment; energy emitting systems comprising primarily laser sources, sensing devices, fiber optics and control connections, especially fixed line connections, mobile Internet connections, computational hardware, computational software, and artificial intelligence systems and related software sold as a unit, all for cosmetic and aesthetic treatment; energy emitting devices and instruments for use in removing and/or altering substances in the body, comprising primarily laser sources, sensing/control devices and optics, parts and accessories therefor, and related software sold as a unit, all for cosmetic treatments; energy emitting devices and instruments comprising primarily laser sources, sensing/control devices and optics, parts and accessories therefor, and related software sold as a unit, used in conjunction with drugs, all for cosmetic and aesthetic use; diode lasers, optical fibers, diffusers, lasers, light sources, lamps, lenses, wave guides, fiber optic probes, parts and accessories therefor, and related software sold as a unit, all for cosmetic and aesthetic use. Energy emitting systems, namely optical and laser-powered systems for use in medical and surgical treatments; energy emitting systems comprising primarily laser sources, sensing/control devices and disposable or reusable attachments, especially ones based on fiber optics and manipulation elements, parts and accessories therefor, all for medical and surgical treatment; energy emitting systems comprising primarily laser sources, sensing devices, fiber optics and control connections, especially fixed line connections, mobile Internet connections, computational hardware, computational software, and artificial intelligence systems and related software sold as a unit, all for medical and surgical treatment; energy emitting devices and medical instruments for use in removing and/or altering substances in the body, comprising primarily laser sources, sensing/control devices and optics, parts and accessories therefor, and related software sold as a unit, all for medical and surgical treatments; energy emitting devices and medical instruments comprising primarily laser sources, sensing/control devices and optics, parts and accessories therefor, and related software sold as a unit, used in conjunction with drugs, all for medical use; diode lasers, optical fibers, diffusers, lasers, light sources, lamps, lenses, wave guides, surgical kits and fiber optic probes, parts and accessories therefor, and related software sold as a unit, all for medical use. Commercial administration of the licensing of procedures for medical and surgical laser/fiber optic treatments.

Abstract

An improved system for safe and efficient generation of plasmas and vapors bubbles with continuous wave radiations and low levels of power densities, sufficient to treat medical pathologies and to avoid the creation damage to healthy tissue is provided. Transmission means in different configurations are used to achieve a high absorption in water, which is able to initiate plasma with low levels of power density. Once plasma and vapor bubbles are formed, they absorb other wavelengths in addition to the one that initiated it. Other wavelengths, more efficiently generated by diodes or diode pumped lasers, are added into the beam to improve treatment efficiency. This modulated plasma produces fast tissue ablation and good hemostasis effect with minimal overheating of remaining tissue. After plasma and high-energy vapors are generated, only laser radiation that passes through the plasma bubble directly interacts with soft tissues.

IPC Classes  ?

• A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
• A61B 18/04 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
• A61B 18/26 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor for producing a shock wave, e.g. laser lithotripsy
• A61N 1/44 - Applying ionised fluids

Abstract

The present invention provides biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PdT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders. The compounds are of the class of β-functionalized hydroxy- and dihydroxy-chlorins having the general formula

IPC Classes  ?

• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 49/00 - Preparations for testing in vivo

Abstract

Minimally invasive methods and devices for endoluminally treating female fallopian tubes or male vas deferens of mammals are presented as a permanent method of contraception. In preferred embodiments, medical devices for male and female sterilization comprise laser radiation source operating at one or more preselected wavelengths between about 980 nm and about 1950 nm, preferably at least one of 980 nm, 1470 nm and 1950 nm; treatment waveguide with a radial or cylindrical radiation emitting tip; viewing scope; and a temperature sensor. In another preferred embodiment, a minimally-invasive permanent contraception method for males and females comprises the steps of introducing at least one treatment waveguide in a body cavity; positioning the treatment waveguide inside a body cavity; irradiating; and repeating the procedure in companion body cavity to inhibit fertilization. In another embodiment, fluids are infused and/or extracted after, before or during the procedure to enhance laser energy absorption and enhance efficiency of laser treatment.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
• A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
• A61B 18/24 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor with a catheter
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

Antimicrobial molecular conjugates for the treatment and prevention of infectious diseases caused by pathogenic microorganisms in human and animals are provided. The conjugates are of the class of compounds of dihydroxychlorins or β-functionalized chlorins connected to carbohydrate moieties and having the general formula

IPC Classes  ?

• C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings
• A61K 31/409 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
• A61K 31/185 - AcidsAnhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates

Abstract

Propionibacterium acnes, Borrelia species and other bacteria found on skin. Further embodiments eliminate undetected or non-easily detected viral agents contaminating blood/blood products responsible for spreading hepatitis, Acquired ImmunoDeficiency Syndrome and other blood borne viral diseases. Human Immunodeficiency, hepatitis B and hepatitis C viruses have emerged as major blood borne infections. Numerous parasites transmitted through bloods and derived products are also eliminated by these processes/devices.

IPC Classes  ?

• A01N 1/02 - Preservation of living parts

Abstract

Non-circular core optical preforms are provided whose core-cladding interface edge has a sharpness that can be accurately controlled according to application-specific needs. Preform design and fiber fabrication is handled such that precisely edged fiber cores are maintained in the drawn fibers. This provides for markedly improved fiber functions, which rely on the non-circular structure of the core. In short, optical fibers having non-circular wave-guiding regions with precise, controlled edges are provided. By using selected manufacturing techniques that employ lower temperatures than commonly used, prior art techniques and by choosing proper materials with appropriate viscosities for core and cladding, the rounding of the edges of the wave-guiding region is precisely maintained in the final optical fibers.

IPC Classes  ?

• G02B 6/02 - Optical fibres with cladding

Abstract

System and method for treating hemorrhoidal piles, addressing both cause and symptoms, by endoluminal/interstitial application of energy are disclosed. The dilated blood arteries in anal/rectal region are irradiated from inside the pile using (laser) energy for minimal pain/discomfort. The center of the pile is irradiated over a certain diameter, absorbing energy; and is denatured causing volume reduction. Central vessels located in the same diameter are obliterated immediately, relieving bleeding. During treatment, new connective tissue replaces the coagulated tissue. Closing inflowing arteries further shrinks piles in weeks to three months. Complications are highly diminished. A hand-piece and a fiber with a sharp distal tip are beneficial. Including an imaging system, (ultrasound imaging, optical coherence tomography) and an intelligent system to calculate necessary laser energy parameters help address each pile individually.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
• A61N 5/067 - Radiation therapy using light using laser light
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves

Abstract

An improved method and device for accurate, efficient surgical procedures are disclosed. The disclosed system consists in simultaneously using an elongated member that conveys energy to a treatment site and imaging means to control position of the elongated member and monitor treatment progress in real-time. In a preferred embodiment, for BPH, a twister fiber with a fused cap is used and ultrasound image guidance is obtained using a rectal probe. The method consists in placing an ultrasound rectal probe, fixed by mechanical means, and an optical fiber inserted into urethra. Initial positioning of probe is done under endoscopic/ultrasound control. The twister fiber probe operates in contact-mode. Treatment is monitored, real-time, by the ultrasound device. Additional imaging technologies include Positron Emission Tomography (PET), Computed Tomography (CT) or Optical Coherence Tomography. Other applications include the removal of tumorous (hyperplasic) tissue. Sources include lasers, higher power LEDs or bright lamps and photodynamic therapy.

IPC Classes  ?

• A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
• A61B 8/08 - Clinical applications
• A61N 5/06 - Radiation therapy using light
• A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
• A61B 18/24 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor with a catheter
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

An improved method and device for safe and efficient medical applications is provided. In a preferred embodiment, based on using the inherent benefits of laser diodes (such as efficient power generation from a reliable and compact solid state device), plasmas and high energy vapors are produced for medical applications with power levels and power densities sufficient to treat medical indications and avoid the creation of extensive damage zones. Transmissions means in different configurations are used to achieve a high power density, which is able to initiate plasma and high-energy vapor at the tip. Once a sparkless plasma and high energy vapor bubbles are formed, it is often found that it will also absorb other wavelengths in addition to the one that initiated it. As a consequence, other wavelengths more efficiently generated by diodes or diode pumped lasers may be added into the beam in order to improve treatment efficiency. For example, the 1470 nm wavelength can be used to produces sparkler-less plasma bubbles, together with the 980 nm wavelength to produce tissue vaporization and an excellent haemostasis effect. Once plasma and or high-energy vapors are in place, radiation from this zone determine tissue effects. In another embodiment, high peak power pulsed radiation is used. Wavelengths of 1470 nm, 1940 nm, or 1550 nm are preferred. Additionally it can be applied in combination with another wavelength with medium absorption in water such as 980 nm. In another embodiment a concentric double core fiber is used, in which the ignition radiation is guided in near single mode, inner core and the radiation used to maintain and enhance the pulse is guided into the surrounding second outer core.

IPC Classes  ?

• A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
• A61B 18/04 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
• A61B 18/26 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor for producing a shock wave, e.g. laser lithotripsy
• A61N 1/44 - Applying ionised fluids

Abstract

2S is provided. In another embodiment substituents are identified that via their steric and/or electronic influence direct the dihydroxylation or reduction with diimine so that one isomer is favored. Another embodiment consists of formulate the desired isomer into a liposomal formulation to be injected avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.

IPC Classes  ?

• A61K 31/409 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
• C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings

Abstract

A method and device for improved minimally invasive vascular treatments. The method comprises introducing a catheter into a vein to be treated. The catheter is adapted to introduce an energy transmitting member and a fluid into the vein to be treated. The fluid introduced via the catheter can include, but is not limited to: saline solutions, cooled saline solutions, liquids for vapor generation, vasoconstricting agents, anesthetic agents and/or a formulation containing an ingredient which can be activated by the applied energy.

IPC Classes  ?

• A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves

Abstract

Methods and devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids are provided. In preferred embodiments, an antimicrobial photodynamic therapy (PDT) treatment is given that effectively inactivates, reduces and/or destroys both Gram (−) and Gram (+) bacteria in complex body fluids. Methods to enhance antimicrobial PDT activity include administering a photosensitizer to bacteria-contaminated fluid, after a dwell time guiding bacteria-contaminated fluid with photosensitizer through a channel, emitting radiation preferably in an intermittent manner, and restoring treated body fluids to corresponding body regions. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. Additionally, the method/device diminishes adverse host's inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
• A61L 2/00 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor

Abstract

The device for carrying out underskin radiation treatment consists of a handpiece that allows easy manipulation by physicians, with a part that can be inserted below the skin and a part that can be held and manipulated outside the body. The part inserted below the skin can be vibrated or oscillated by means of suitable transducers to aid in distributing the radiation. Simultaneously or immediately afterwards, liquefied tissue is aspirated. If convenient, fluid irrigation of the area to be treated can be done. In a preferred embodiment, handpiece consists in a hollow cannula incorporating at least one channel for suction and/or irrigation and a light guiding means in its body/wall section for the purpose of the treatment and liquefaction of adipose tissue. The device further comprises at least one radiation source, included in device part affixed to the handpiece either in a permanent or detachable manner.

IPC Classes  ?

• A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser

Abstract

An improved device and method for safe, accurate and efficient surgical procedures are disclosed. The disclosed device is an optical fiber set with an asymmetric distal end configuration, comprising a bent tip fiber with a fused sleeve as an integral part of it, placed at the fiber's distal (output) end and with a rotatable connector at the proximal (input) side. Fiber tip and tissue-contacting surface located at the distal end of the tip may be constructed with different shape configurations, such as convex tip to improve focusing characteristics, concave tip to achieve diverging irradiation or an expanded beam tip to achieve an effect similar to that obtained by electrosurgical tools. A grip guarantees and enhances the ability to twist and rotate it easily. In another preferred embodiment, twisting maneuvers are enhanced through a special configuration. Both special features (bent tip and rotatable connector), allow for improved and enhanced treatment of diverse pathologies, making possible to efficiently and easily reach and treat specific tissues. Optical fiber's steerability, twistability and rotation lead to a more precise and improved effect on tissues.

IPC Classes  ?

• A61B 18/16 - Indifferent or passive electrodes for grounding

Abstract

Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for photodynamic therapy comprising a hydrophobic photosensitizer, human serum albumin (HSA) and stabilizing agent are provided. These nanoparticulate formulations provide therapeutically effective amounts of photosensitizer (PS) for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers whose efficacy and safety are enhanced by such nanoparticulate formulations. A method of preparing the HSA-based nanoparticles under sterile conditions is also provided. In one of the preferred embodiments of the present invention temoporfin, a hydrophobic PS, is formulated as a nanoparticle for parenteral administration. The formulations are useful for treating hyperplasic and neoplasic conditions, inflammatory problems, and more specifically to target tumor cells.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 31/409 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
• A61K 33/20 - Elemental chlorineInorganic compounds releasing chlorine
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation

Abstract

An improved device and method for safe, accurate and efficient surgical procedures are disclosed. The disclosed device is an optical fiber set with an asymmetric distal end configuration, comprising a bent tip fiber with a fused sleeve as an integral part of it, placed at the fiber's distal (output) end and with a rotatable connector at the proximal (input) side. Fiber tip and tissue-contacting surface located at the distal end of the tip may be constructed with different shape configurations, such as convex tip to improve focusing characteristics, concave tip to achieve diverging irradiation or an expanded beam tip to achieve an effect similar to that obtained by electrosurgical tools. A grip guarantees and enhances the ability to twist and rotate it easily. In another preferred embodiment, twisting maneuvers are enhanced through a special configuration. Both special features (bent tip and rotatable connector), allow for improved and enhanced treatment of diverse pathologies, making possible to efficiently and easily reach and treat specific tissues. Optical fiber's steerability, twistability and rotation lead to a more precise and improved effect on tissues. Due to this, easier, faster and more precise and efficient treatments can be performed by its means. For instance, it may be inserted into a cystoscope to perform high power ablation of prostatic tissue for BPH treatments, or steered into one of the prostatic lobes, which can be excavated from the inside in order to relieve pressure on the urethra while maintaining the urethra's integrity. Other uses might be the removal of tumorous, hyperplasic or other unwanted tissue in the body. Optical fiber set disclosed can be used with laser sources of various wavelengths, including dual laser sources, but also higher power LED devices or very bright light sources can be used to generate the radiation to be transmitted as well. Due to this novel design, described fiber is easy to put in place, also easy to maintain in contact with tissue and highly durable. The feel to the doctor is greatly improved too. This results in more effective power transfer into tissue and therefore procedures are more reliable and procedure times are cut by up to 30%.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
• G02B 6/00 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings

Abstract

A device and method for restoring functionality of blood vessels are disclosed. Laser energy is accurately and precisely applied in order to restore vessel functionality. This is accomplished by a controlled, reliable and specific shrinkage and/or strengthening of the vessel structure by controlled transport of laser radiation via an optical fiber to the treatment site. Laser wavelength is chosen according to the required penetration depth in tissue. In a preferred embodiment, wavelength of approximately 1470 nm is used. A mini-endoscope is preferably used to control the process by visual inspection from the inside of the vessel but other means may also be combined to control the procedure. Full 360° radial emission, i.e., delivery of laser radiation perpendicularly or fairly inclined relative to the veins axis, is beneficial, and is accomplished by means of a radial emitting fiber. In another preferred embodiment, a 360 degree radiation pattern can be achieved by using a twister or side-emitting fiber, along with rotational and sweeping movements to apply energy in an even, more-controlled, and guided manner. Valve function is restored to recover whole vein functionality, avoiding the need of closing it. In a preferred embodiment, energy is applied from the outside of the vessel, by inserting a device through the skin and tissue. In another preferred embodiment, specific radiation absorbers are located at suitable positions inside the vessel wall, to selectively target radiation to tagged locations. Vessel function is restored preserving its structure. A wide range of vessel diameters are effectively treated. Vessels include veins, arteries and fistulas.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light

Abstract

A PhotoDynamic Therapy (PDT) method is presented for cosmetic rejuvenation, which is exemplified by a two phase approach for treating facial and neck skin aging while minimizing damage to the underlying region of skin being treated. To obtain best results a combination of treatments are used. This includes applying photosensitizer and light energy for stimulating the collagen within the skin, thereby restoring the elasticity of skin. The treatment procedures take about six weeks consisting of impair (damage) and repair (recovery) sessions involving skin preparation by peeling, skin detoxification, application and distribution of photosensitizer to the skin, irradiation of pre-sensitized skin followed by removal of mask. Results of long lasting improvement, especially in comparison with most cosmetic treatments, are obtained upon completion of the series, with marked changes being observed after individual sessions, which provide added incentive to complete a treatment program. These results eliminate the need for repetitive treatments after the six week series, unlike most current approaches which require repeat sessions semi-annually or annually.

IPC Classes  ?

• A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves

Abstract

Oral formulations and method of formulating photosensitive agents for oral administration during photodynamic therapy (PDT) and Antimicrobial photodynamic therapy (APDT) treatment are presented. The oral formulated photosensitizers show increased solubility and permeability, thus improving the bioavailability of photosensitizers at the treatment site. An orally administered photosensitizer is suitably formulated for mucosal adhesion and absorption via gastrointestinal mucosal membranes. Oral formulation provided herein use lipids and known proteins as carriers for photosensitizers by oral route. Carriers for encapsulating preselected photosensitizers include conventional liposomes, pegylated liposomes, nanoemulsions, nanocrystrals, nanoparticles, fatty emulsions, lipidic formulations, hydrosols, SMEDDS, Alpha-Feto protein (AFP), and Bovine-Serum-Albumin (BSA), fatty emulsions, hot-melt-extrudates and nanoparticles. The oral formulation, in case of a hydrophobic photosensitizer in the present invention, is stabilized using suitable surfactants/solubilizers thus preventing aggregation of the drug in the stomach and until it is absorbed in the duodenum and the small intestine. Oral formulations can be administered in the form of liquid, capsule, tablet, powder, paste or gel. Formulated drugs can be administered orally as one single dose or in multiple doses before administering PDT. In one embodiment Temoporfin (m-THPC) is used as a photosensitizer in the oral formulations. Temoporfin like many hydrophobic photosensitizers are especially suitable to be administered orally because there is no known enzyme system in the mammalian body which can metabolize Temoporfin or similar photosensitizers. Temoporfin can reach the blood system unchanged and fully active after absorption of the formulation in the gastrointestinal tract.

IPC Classes  ?

• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/409 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine

Abstract

A device for improved surgical procedures to remove unwanted or hyperplasic tissue from a patient during laser ablation, urological treatments, benign prostatic hyperplasia treatments and other applications. Specially prepared optical waveguide tips allow for enhanced irradiation of desired tissues with light sources including laser diodes, bright LEDs or lamps. A significant fraction of the optical radiation, being transported in the waveguide, is coupled out of the waveguide into the surrounding medium through a peripheral surface at or near the distal end. The optical radiation is chosen to have an appropriate wavelength and sufficient power density, so that the surrounding medium will be changed in the vicinity of at least a part of the peripheral surface area. The changes of the surrounding medium result in a change of its refractive index such that the optical radiation is redirected.

IPC Classes  ?

• A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves

Abstract

The invention relates to a system for medicinal treatment, in particular for treating benign prostatic hyperplasia BPH, for use in the event of tumor resection or for use in thoracic surgery. The system comprises a diode laser device for producing a laser beam and to an application system based on optical wave guides that can be endoscopically introduced into a patient. Said system is designed in such a manner that the laser beam, produced by the diode laser device is guided through the application system and is emitted by said application system so that biological tissue can be treated in a selective manner with the emerging laser beam.

IPC Classes  ?

• A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
• A61B 18/24 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor with a catheter
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body

Abstract

An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Additional embodiments include spacing/centering mechanisms to keep emitting end radially equidistant from vein walls. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.

IPC Classes  ?

• A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
• A61B 18/24 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor with a catheter
• A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
• A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor

Abstract

Antimicrobial molecular conjugates for the treatment and prevention of infectious diseases caused by pathogenic microorganisms in human and animals are provided. The key to these conjugates is a special spacer connecting at least one photosensitizer to a microorganism receptor (vector) which in turn binds selectively to the surface of a microorganism bringing about photo-destruction upon irradiation. Spacers having hydrophilic structure such as ethylene glycol units and amino carboxyl end capped ethylene glycol units must be used for linking the vector to the photosensitizer. In a preferred embodiment a spacer would have at least 3 ethylene glycol units and be end capped with a carboxyl group on one end and a amino group at the other end. The present invention effectively works to combat bacterial infection in the real patient-related environments where blood, serum and other body fluids are always present or at least nearby. Spacers of selected length and structure, in preferred embodiments, are used for linking the vector to the photosensitizer. These conjugate are found to be very effective in combating bacterial infection in the real patient-related environments where blood, serum and other body fluids are always present or a least nearby. A method of use is also provided.

IPC Classes  ?

• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation

Abstract

An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.

IPC Classes  ?

• A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
• A61B 18/24 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor with a catheter
• A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
• A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor

Abstract

An improved method and device is provided for safe and efficient low power density endoluminal treatment of ve-nous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial direc-tions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.

IPC Classes  ?

• A61B 18/24 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor with a catheter

Abstract

The present invention relates to improved methods of formulations of hydrophobic photosensitizers, and their precursors, for mucosal administration. The formulation of the invention comprises of hydrophobic photosensitizers which have been incorporated into suitably sized liposomes. Additionally, these formulations include the incorporation of PS-loaded liposomes into a copolymer matrix. The liposome of the present invention allows the hydrophobic photosensitizers to be incorporated into the thermogel matrix and thus promoting intimate contact between the formulation and the mucosal layer for enhanced drug absorption.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation

Goods & Services

Optical fibers for delivery of laser energy for medical treatments. Medical services. Licensing of medical procedures.

Abstract

A new treatment regime is presenter using a low concentration formulation at a low dosage of hydrophobic photosensitizers (PS) that shows improved pharmacokinetics and an effective method for photodynamic therapy (“PDT”). The new formulation has better pharmacological effect compared to standard photosensitizer formulation with standard dosage. It was found that PDT treatments using the disclosed low concentration formulations provide for more accurate, more efficient and more convenient dosing. It was found that the inventive formulation; (1) reduces the time for a therapeutically effective level of photosensitizer to accumulate in diseased tissue; and, (2) reduces the time for achieving a sufficient ratio of photosensitizer in diseased tissue vs. healthy tissue. As a result, the formulation of the invention reduces the time interval between PS application/administration and irradiation (the drug-light interval or “DLI”) and can provide for a “same day” PDT treatment option. The inventive formulation can be used for PDT treatment regimes where photosensitizers are administered in at least one preselected dose, including a low concentration therapy for PDT. In particular, when meta-(Tetrahydroxyphenyl)Chlorin (m-THPC) is the photosensitizer, then a concentration of 0.8 mg/ml to 0.04 mg/ml in a mixture of pure propylene glycol and ethanol in a 3:2 volume ratio accumulates in diseased tissue and differentiates between diseased tissue and normal tissue sufficiently quickly for ‘one day’ or overnight administration and activation treatment procedures to be possible.

IPC Classes  ?

• A61K 31/409 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine

Abstract

A method and device used for treating body cells affected by abnormal cell growth or by oncogenic viruses. In particular the invention relates to photonic device for treating gynecological problems comprising at least one light source incorporated into the irradiation head or into the hand piece or as a external unit connected by light guide. The light source used in the photonic device has a LED, Laser or lamps. This photonic device is used for treating a subject having unwanted cell proliferation, example dysplasia of the portio and/or cervix with Photodynamic therapy (PDT). The advantage of using LED device is, for its radiation safety, cost effectiveness and is easy to handle compared to laser system. A drug applicator is also described which is employed for homogenously application of photoactive drug in the affected area.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light

Abstract

A device and method are provided which achieve tissue ablation as well as tissue coagulation substantially simultaneously during the treatment of BPH by utilizing at least two wavelengths of light. The device and method improve urinary flow and minimize post-treatment blood loss and edema while maintaining a nearly blood-free operating field during treatment by irradiating substantially simultaneously with at least two different wavelengths of light. The present device and method uses optical fibers including in preferred embodiments special side emitting optical fibers to provide a practical, minimally invasive treatment of enlarged prostates. According to the present invention, tissue ablation is affected by having one wavelength that is highly absorbed in the prostatic tissue while another less highly absorbed wavelength coagulates surrounding hyperplasic tissues while maintaining minimal thermal damage to normal tissue, surrounding the hyperplasia. In a preferred embodiment the highly absorbed wavelength is about 1460 nm and the less absorbed by water but with some significant hemoglobin absorption is about 980 nm. This combination aids the patient by reducing blood loss and edema. It can aid the practitioner, especially where imaging is employed, by maintaining a substantially blood-free area during treatment.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light

Abstract

A method and device (100) for cosmetic surgery, especially fat reduction and collagen reformation, by means of a high power laser operating at about 980 nm is presented. The cosmetic surgery method substantially reduces or removes localized lipodystrophies, and essentially reduces flaccidity by localized laser heating of adipose tissue using an optical fiber (102) inserted into a treatment area. The method and device (100) are particularly well suited for treating Lipodystrophies with flaccidity High power laser energy is applied to "fat" cells to breakdown the cell walls releasing the cell fluid. The laser radiation is applied through an optical fiber (100), which may be held within a catheter-like device having a single lumen. The optical fiber may have a diffuser mounted on the tip to further apply heating to tissues surrounding the whole tip. A saline solution may also be inserted into the treatment site to aid in the heating of the fat cells and their eventual destruction as well as their removal. The pool of cell fluid in the area of treatment is removed by a combination of techniques including allowing the body to remove it by absorption and drainage from the entry sites thus minimizing trauma to the area of treatment and hastening recovery. Additional techniques to remove the cell fluid include direct force application by means of elastic bandages and external suction applied to the entry sites. Quick and lasting cosmetic changes, even in areas having prior untreatable fat tissues, are achieved while minimizing trauma to the treatment areas.

IPC Classes  ?

• A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves

Abstract

A method and device for cosmetic surgery, especially fat reduction and collagen reformation, by means of a high power laser operating at about 980 nm is presented. The cosmetic surgery method substantially reduces or removes localized lipodystrophies, and essentially reduces flaccidity by localized laser heating of adipose tissue using an optical fiber inserted into a treatment area. The method and device are particularly well suited for treating Lipodystrophies with flaccidity High power laser energy is applied to “fat” cells to breakdown the cell walls releasing the cell fluid. The laser radiation is applied through an optical fiber which may be held within a catheter-like device having a single lumen. The optical fiber may have a diffuser mounted on the tip to further apply heating to tissues surrounding the whole tip. A saline solution may also be inserted into the treatment site to aid in the heating of the fat cells and their eventual destruction as well as their removal. The pool of cell fluid in the area of treatment is removed by a combination of techniques including allowing the body to remove it by absorption and drainage from the entry sites thus minimizing trauma to the area of treatment and hastening recovery. Additional techniques to remove the cell fluid include direct force application by means of elastic bandages and external suction applied to the entry sites. Quick and lasting cosmetic changes, even in areas having prior untreatable fat tissues, are achieved while minimizing trauma to the treatment areas.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light
• A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
• A61B 18/24 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor with a catheter
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

A low concentration formulation for hydrophobic photosensitizers (PS) and improved method for photodynamic therapy ("PDT"). It was found that PDT treatments using the disclosed low concentration formulations provide for more accurate, more efficient and more convenient dosing. It was found that the inventive formulation (1) reduces the time for a therapeutically effective level of photosensitizer to accumulate in diseased tissue and (2) reduces the time for achieving a sufficient ratio of photosensitizer in diseased tissue vs. healthy tissue. As a result, the formulation of the invention reduces the time interval between PS application/administration and irradiation (the drug-light interval or "DLI") and can provide for a "same day" PDT treatment option. The inventive formulation can be used for PDT treatment regimes where photosensitizers are administered in at least one preselected dose, including a low concentration therapy for PDT. In particular, when meta Tetra-Hydroxy-Phenyl Chlorin (m-THPC) is the photosensitizer then a concentration of 0.8 mg/ml to 0.04 mg/ml in a mixture of pure propylene glycol and ethanol in a 3:2 volume ratio accumulates in diseased tissue and differentiates between diseased tissue and normal tissue sufficiently quickly for 'one day' or overnight administration and activation treatment procedures to be possible.

IPC Classes  ?

• A61P 35/00 - Antineoplastic agents

Abstract

The present invention provides methods and compositions for increasing the effectiveness of photodynamic therapy (“PDT”) and for reducing the duration of skin phototoxicity associated with PDT treatment. The disclosed methods generally include the administration of a lipid composition before, during, or after the administration of photosensitizers used in the PDT treatment protocol. The lipids are preferably phospholipids. It was discovered that the disclosed methods resulted in a more rapid clearance of photosensitizers from the skin and other tissue of patients, which results in a shorter period of skin phototoxicity after PDT treatment. The present invention also provides a composition which is preferably comprised of non-polar photosensitizers and phospholipids.

IPC Classes  ?

• B32B 27/30 - Layered products essentially comprising synthetic resin comprising vinyl resinLayered products essentially comprising synthetic resin comprising acrylic resin
• C08K 5/04 - Oxygen-containing compounds
• C08K 5/09 - Carboxylic acidsMetal salts thereofAnhydrides thereof

Goods & Services

Lasers, light sources, lamps, lenses, wave guides, diffusers, diodes, semiconductor diodes, catheters, cutaneous applicators for applying pharmaceuticals and cosmetic preparations, and optical fibers, all for medical and surgical use, and accessories therefor Manufacture of optical fibers, fiber assemblies, diode lasers, diode-pumped lasers, and light-activated, photo-activated and laser-activated preparations and topical preparations to order and/or specification of others

Goods & Services

optical Quartz fibers [ and optical silver halide fibers ] for transmitting optical signals used in industrial and scientific applications light conducting quartz fibers [ and silver halide fibers ] for medical and surgical use

Goods & Services

optical Quartz fibers [and] for transmitting optical signals used in industrial and scientific applications light conducting Quartz fibers for medical and surgical use

Goods & Services

OPTICAL AND LASER-POWERED SYSTEMS FOR USE IN MEDICAL AND SURGICAL VASCULAR TREATMENTS COMPRISING PRIMARILY A LASER SOURCE, A SENSING/CONTROL DEVICE AND OPTICS FOR VASCULAR TREATMENTS, AND PARTS AND ACCESSORIES THEREFOR; DIFFUSERS FOR MEDICAL AND SURGICAL USE; DIODE LASERS FOR USE IN MEDICAL AND SURGICAL INSTRUMENTS; OPTICAL FIBERS FOR USE IN MEDICAL AND SURGICAL INSTRUMENTS; LASERS, LIGHT SOURCES, LAMPS, LENSES, WAVE GUIDES, AND FIBER OPTIC PROBES, AND PARTS AND ACCESSORIES THEREFOR, ALL FOR MEDICAL USE Licensing of procedures for medical and surgical vascular treatments

Goods & Services

Lasers, light sources, [ lamps, lenses, wave guides, diffusers, diodes, semiconductor diodes, catheters, cutaneous applicators for applying pharmaceuticals and cosmetic preparations, ] and optical fibers, all for medical and surgical use, and accessories therefor Custom manufacturing of optical fibers, fiber assemblies, diode lasers, diode-pumped lasers, and light-activated, photo-activated and laser-activated preparations and topical preparations

Goods & Services

PHARMACEUTICAL PREPARATIONS AND SUBSTANCES FOR THE TREATMENT OF CANCER; DIETETIC SUBSTANCES ADAPTED FOR MEDICAL USE, NAMELY, FOOD FOR MEDICALLY RESTRICTED DIETS; PHOTOSENSITISOR COMPOUNDS FOR CLINICAL MEDICAL DIAGNOSTIC USE

Goods & Services

quartz fibers and silver halide fibers for use with industrial and scientific applications [ quartz fibers and silver halide fibers for use with medical and surgical applications ]

Goods & Services

lasers for use in medical procedures and surgical procedures

Goods & Services

optical fibers custom manufacturing of optical fibers

Goods & Services

optical fibers custom manufacturing of optical fibers