Abstract

Tellurium-containing compounds identified for use in a method of treating, or prophylaxis against, a viral infection caused by an influenza virus, uses thereof and pharmaceutical kits and pharmaceutical compositions comprising the same, are disclosed. The tellurium-containing compounds disclosed herein are suitable for co-administration with an antiviral agent.

IPC Classes  ?

• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
• C07C 395/00 - Compounds containing tellurium
• A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

A method of reducing a level of an anli-HLA antibody in a subject in need of organ transplantation may comprise administering to the subject a therapeutically effective amount of a tellurium-containing compound. The tellurium-containing compound may have at least one tellurium dioxo moiety and may have a general formula selected from the group consisting of tellurium dioxide (TeO2), a complex of TeO2, and compounds having general formulas such that AS101 is one specific example of one of the general formulas. Also disclosed are methods of using such tellurium-containing compounds in preparing medicaments for use in reducing a level of an anti-HLA antibody in a subject in need of organ transplantation. Pharmaceutical compositions comprising tellurium-containing compounds for organ transplantation are also disclosed.

IPC Classes  ?

• A01N 59/16 - Heavy metalsCompounds thereof

Abstract

Use of tellurium-containing compounds for maintaining and/or augmenting fertility in a male subject following chemotherapy and/or radiotherapy is disclosed. The tellurium-containing compound is utilized in combination with a chemotherapeutic agent and/or radiation, such that the male subject treated by the chemotherapeutic agent and/or radiation and by the tellurium-containing compound is instructed to refrain from conceptive sex for a pre-determined time period, following the chemotherapy and/or radiotherapy, during which conception is undesired.

IPC Classes  ?

• A01N 31/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
• A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols

Abstract

Use of tellurium-containing compounds in a method of conception and/or for maintaining and/or augmenting fertility in female following chemotherapy and/or radiotherapy is disclosed. The tellurium-containing compound is utilized in combination with a chemotherapeutic agent and/or radiation, such that the female treated by the chemotherapeutic agent and/or radiation and by the tellurium-containing compound is instructed to refrain from conceptive sex for a pre-determined time period, following the chemotherapy and/or radiotherapy, during which conception is undesired. The tellurium-containing compound is utilized in combination with a chemotherapeutic agent and/or radiation, such that the female treated by the chemotherapeutic agent and/or radiation and by the tellurium-containing compound is instructed to refrain from sex and/or from reproduction for a pre-determined time period, and is then allowed to practice reproduction.

IPC Classes  ?

• A01N 31/00 - Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
• A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols

Abstract

Compositions and methods for inhibiting integrin and treating integrin-related conditions, utilizing tellurium-containing compounds, are disclosed. The tellurium-containing compounds comprise at least one tellurium dioxo moiety and may have any one of Formulae I to IV as defined in the specification. Further disclosed are compositions and methods for treating a neoplastic condition characterized by a resistance to an anti-neoplastic agent and by a high level of expression of an integrin by neoplastic cells.

IPC Classes  ?

• A01N 59/16 - Heavy metalsCompounds thereof
• A61K 31/33 - Heterocyclic compounds

Abstract

Methods and compositions utilizing tellurium-containing compounds such as AS101 for the treatment of pox viruses such as Molluscum contagiosum virus are disclosed.

IPC Classes  ?

• A01N 59/16 - Heavy metalsCompounds thereof
• A61K 31/33 - Heterocyclic compounds

Abstract

Novel formulations of tellurium-containing compounds, which are suitable for topical application, are disclosed. The formulations are characterized by high chemical and physical stability and are easy to handle and use.

IPC Classes  ?

• A61K 33/00 - Medicinal preparations containing inorganic active ingredients
• A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof