Disclosed is a method for modulating activity in a nerve, in which a blocking stimulation signal is applied at a blocking location at the nerve. The blocking stimulation signal comprises a biphasic pulsatile electrical signal having a frequency of between about 100 Hz to about 40 kHz and a steady state duty cycle of greater than about 75% and less than 100%. Also disclosed is a system configured to modulate activity in a nerve and an electrode array for stimulating a nerve.
Disclosed is a method for characterising tinnitus in a subject. The method comprises receiving data comprising cortical activity data indicative of cortical activity in one or more regions of the subject's brain, and cardiac activity data indicative of cardiac activity in the subject, at a processor device. The cortical activity data is derived from one or more functional near-infrared spectroscopy (fNIRS) signals. The received data is processed using the processor device by inputting feature values into a model, where the feature values include one or more features of the cortical activity data and one or more features of the cardiac activity data. The model is configured to provide one or more classification results based on the feature values, the classification results being indicative of at least one characteristic of tinnitus in the subject. Also disclosed is a system for applying the disclosed method.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61M 21/00 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
Embodiments generally relate to a method of assessing the hearing of a patient using functional near-infrared spectroscopy (fNIRS). The method comprises receiving at least one response signal from an optode placed on a scalp of the patient, the response signal comprising fNIRS data generated by the optode and relating to an aural stimulation received by the patient; comparing at least one parameter of the at least one response signal to a predetermined parameter value; and determining an auditory response of a patient based on the at least one parameter of the at least one response signal.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
Described embodiments generally relate to a method of assessing the hearing of a subject. The method comprises presenting a first aural stimulus to the subject; presenting a second aural stimulus to the subject, the second aural stimulus being different to the first aural stimulus; receiving at least one physiological response signal relating to the second aural stimulus received by the subject; comparing at least one parameter related to the at least one physiological response signal with a control parameter; and determining an auditory discrimination response of the subject based on the outcome of the comparison.
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
The present disclosure relates to improved supraparticles loaded with high levels of payload and methods for their production. Such supraparticles may be used in a range of therapeutic applications, for example, to improve growth or survival of cells and/or treat disease.
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
Methods and systems are disclosed for modulating glycaemia in a patient in which an activating stimulation signal is applied at an activating location at the vagus nerve, the activating stimulation signal configured to evoke a neural response in the vagus nerve; and a blocking stimulation signal is applied at a blocking location at the vagus nerve, the blocking stimulation signal configured to inhibit transmission of the evoked neural response along the vagus nerve past the blocking location; to produce unidirectional vagal nerve stimulation, the unidirectional vagal nerve stimulation being effective to modulate glycaemia in the patient.
The present invention relates to methods of treating an auditory disorder. In particular, the present invention relates to treating an auditory disorder using supraparticles comprising a therapeutic payload.
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A method of detecting neural activity in a nerve is disclosed. A first electrical signal is received from a first pair of electrodes. A second electrical signal is received from a second pair of electrodes, the second pair of electrodes being spaced from the first pair of electrodes along the nerve. A correlation analysis is applied between the first and second electrical signals, including for at least one non-zero lag time, to obtain correlation data. From the correlation data, at least one neural signal is detected, indicative of neural activity in the nerve. The neural signal corresponds to increased correlation between the first and second signals at the at least one non-zero lag time.
Disclosed is a method for stimulating neural tissue, where the neural tissue includes one or more neurons genetically modified to express a light-sensitive protein. The method comprises applying a light stimulus and an electrical stimulus to the neural tissue, thereby triggering membrane depolarisation in at least one of the neurons. Also disclosed is an apparatus for applying the disclosed method. The apparatus includes a light-stimulation device for selectively applying a light stimulus and an electrical-stimulation device for selectively applying an electrical stimulus to the neural tissue.
16 - Paper, cardboard and goods made from these materials
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medical apparatus and instruments; electronic medical
apparatus; medical diagnostic devices and instruments;
medical devices and instruments for monitoring and treating
health and medical conditions; medical implants; wearable
medical devices; hearing aids; apparatus for use in
alleviating hearing disorders; apparatus for use in treating
hearing disorders; apparatus for use in the diagnosis,
monitoring and treatment of neurological conditions and
central nervous system disorders, including parkinson's
disease and epilepsy; sensors (measurement apparatus) for
medical use. Printed matter; printed publications; printed journals;
printed newsletters and magazines; all the aforementioned
being in relation to medical research and medical matters. Medical research; medical research in the field of
neurological conditions and central nervous system
disorders; medical research in the field of parkinson's
disease; medical research in the field of epilepsy; medical
research in the field of hearing disorders; technological
research and design in the field of medical devices,
apparatus and instruments; technological research and design
of computer hardware, firmware and software for use in the
medical field; software as a service (saas) for use in the
medical field; platforms as a service (paas) for use in the
medical field; installation, maintenance and repair of
computer firmware and computer software for use in the
medical field.
Disclosed is electrical apparatus for stimulating and/or monitoring an eye of a patient, comprising an implantable electrode device and a lead extending outwardly from the implantable device, the lead including a section that locates externally to the eye having at least one pre-formed bend. Also disclosed is a lead connected to an implantable electrode device, the lead having one or more stripes that extend along at least a portion of the lead. Also disclosed is an implantable device having a substrate and at least one electrode, the electrode having at least one aperture through which material of the substrate extends to anchor the electrode to the substrate. Other disclosed features relate to a foldable anchor device, a curved electrode substrate and depth markers, for example.
The present disclosure relates to supraparticles loaded with high levels of payload and having controlled payload release profiles. In particular, supraparticles made of mesoporous silica nanoparticles and elecrosprayed with alginic acid which is then coated or formulated with biodegradable materials is disclosed. Such supraparticles may be used in a range of therapeutic applications.
16 - Paper, cardboard and goods made from these materials
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medical apparatus and instruments, namely, medical apparatus and instruments for use in neuromodulation and medical apparatus and instruments for the diagnosis, monitoring, management and treatment of hearing disorders; electronic medical apparatus, namely, electronic medical apparatus for use in neuromodulation and the electronic medical apparatus for the diagnosis, monitoring, management and treatment of hearing disorders; medical diagnostic devices and instruments, namely, medical diagnostic devices and instruments for use in neuromodulation and medical diagnostic devices and instruments for the diagnosis, monitoring, management and treatment of hearing disorders; medical devices and instruments for monitoring and treating health and medical conditions, namely, medical devices and instruments for monitoring and treating health and medical conditions by way of neuromodulation and medical devices and instruments for monitoring and treating health and medical conditions, namely, hearing disorders, epilepsy and parkinson's disease; medical implants, namely, medical implants for use in neuromodulation and medical implants for the diagnosis, monitoring, management and treatment of hearing disorders, epilepsy and parkinson's disease, all being made from artificial materials; wearable medical devices, namely, wearable medical devices for use in neuromodulation and wearable medical devices for the diagnosis, monitoring, management and treatment of hearing disorders, epilepsy and parkinson's disease; hearing aids; apparatus for use in alleviating hearing disorders, namely, hearing aids and cochlea implants made of artificial materials; apparatus for use in treating hearing disorders, namely, hearing aids and cochlea implants made of artificial materials; apparatus for use in the diagnosis, monitoring and treatment of neurological conditions and central nervous system disorders, including parkinson's disease and epilepsy; sensors being measurement apparatus for medical use, namely, biofeedback sensors Printed matter, namely, books, journals, magazines and brochures in the field of medical research and medical practice; printed publications, namely, books, journals, magazines and brochures in the field of medical research and medical practice; printed journals in the field of medical research and medical practice; printed newsletters and printed magazines in the field of medical research and medical practice; all the aforementioned being in relation to medical research and medical matters Medical research; medical research in the field of neurological conditions and central nervous system disorders; medical research in the field of parkinson's disease; medical research in the field of epilepsy; medical research in the field of hearing disorders; technological research and design in the field of medical devices, apparatus and instruments; technological research and design of computer hardware, firmware and software for use in the medical field; software as a service (saas) for use in the medical field featuring software for diagnosing, monitoring, managing, and treating health and medical conditions; platforms as a service (paas) for use in the medical field featuring software platforms for diagnosing, monitoring, managing, and treating health and medical conditions; installation, maintenance and repair of computer firmware and computer software for use in the medical field, namely, for use with medical devices for the diagnosis, monitoring, management and treatment of health and medical conditions
14.
CHARACTERISING TINNITUS USING FUNCTIONAL NEAR-INFRARED SPECTROSCOPY
Disclosed is a method for characterising tinnitus in a subject using functional near-infrared spectroscopy (fNIRS). The method comprises receiving data comprising fNIRS signals indicative of cortical activity in one or more regions of the subject's brain at a processing device. The received data is processed using the processor device by inputting one or more feature values into a model, where the feature values include one or more features of the received data. The model is configured to provide one or more classification results based on the one or more feature values, the classification results being indicative of at least one characteristic of tinnitus in the subject. Also disclosed is a system for applying the disclosed method.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
G06K 9/62 - Methods or arrangements for recognition using electronic means
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The present disclosure relates to a peripheral nerve electrode array that includes a first, second and third pair of electrodes spaced from each other along a longitudinal axis of the electrode array, the second pair of electrodes being located between the first and third pairs of electrodes. The present disclosure further relates to method for treating or preventing a chronic inflammatory condition in a human subject in need thereof, comprising providing to the human subject a therapeutically effective electrical stimulation of the anterior central abdominal vagus nerve or the posterior central abdominal vagus nerve, wherein the electrical stimulation is provided through two or more previously implanted electrodes at a site below the cardiac branches and above the hepatic-celiac branches of the nerve; and whereby the chronic inflammatory condition is prevented or treated in the human subject. In addition, the present disclosure relates to a method for treating or preventing a chronic inflammatory condition in a human subject in need thereof.
Embodiments generally relate to a method of determining a hearing threshold value for a subject. The method comprises receiving at least one first response signal relating to an aural stimulation experienced by the subject at a first intensity level; receiving at least one second response signal relating to an aural stimulation experienced by the subject at a second intensity level, wherein the second intensity level is below an expected hearing threshold for the subject; calculating at least one first value relating to the at least one first response signal; calculating a second value relating to the at least one second response signal; plotting the at least one first value against the first intensity level on a plot; calculating a regression curve that fits the plot; and determine the hearing threshold of the subject to be the intensity level that corresponds to the second value along the regression curve.
Methods and systems are disclosed for modulating glycaemia in a patient in which an activating stimulation signal is applied at an activating location at the vagus nerve, the activating stimulation signal configured to evoke a neural response in the vagus nerve; and a blocking stimulation signal is applied at a blocking location at the vagus nerve, the blocking stimulation signal configured to inhibit transmission of the evoked neural response along the vagus nerve past the blocking location; to produce unidirectional vagal nerve stimulation, the unidirectional vagal nerve stimulation being effective to modulate glycaemia in the patient.
Disclosed is a method for stimulating neural tissue, where the neural tissue includes one or more neurons genetically modified to express a light-sensitive protein. The method comprises applying a light stimulus and an electrical stimulus to the neural tissue, thereby triggering membrane depolarisation in at least one of the neurons. Also disclosed is an apparatus for applying the disclosed method. The apparatus includes a light-stimulation device for selectively applying a light stimulus and an electrical-stimulation device for selectively applying an electrical stimulus to the neural tissue.
A method of detecting neural activity in a nerve is disclosed. A first electrical signal is received from a first pair of electrodes. A second electrical signal is received from a second pair of electrodes, the second pair of electrodes being spaced from the first pair of electrodes along the nerve. A correlation analysis is applied between the first and second electrical signals, including for at least one non-zero lag time, to obtain correlation data. From the correlation data, at least one neural signal is detected, indicative of neural activity in the nerve. The neural signal corresponds to increased correlation between the first and second signals at the at least one non-zero lag time.
The present disclosure relates to supraparticles loaded with high levels of payload and having controlled payload release profiles. In particular, supraparticles made of mesoporous silica nanoparticles and elecrosprayed with alginic acid which is then coated or formulated with biodegradable materials is disclosed. Such supraparticles may be used in a range of therapeutic applications.
Disclosed is electrical stimulation apparatus and an associated method for delivering therapy to an eye of a patient is disclosed, the apparatus comprising: an implantable device comprising one or more electrodes for delivering therapeutic electrical stimulation to the eye, the implantable device being configured for implanting in a suprachoroidal space between the sclera and choroid layers of the eye. Also disclosed is electroretinography (ERG) apparatus for monitoring an eye of a patient, the apparatus comprising: an implantable device comprising one or more electrodes for monitoring properties of the eye, the implantable device being configured for implanting in a suprachoroidal space between the sclera and choroid layers of the eye. Also disclosed are implantable devices, apparatuses and methods for the eye.
Disclosed is electrical apparatus for stimulating and/or monitoring an eye of a patient, comprising an implantable electrode device and a lead extending outwardly from the implantable device, the lead including a section that locates externally to the eye having at least one pre-formed bend. Also disclosed is a lead connected to an implantable electrode device, the lead having one or more stripes that extend along at least a portion of the lead. Also disclosed is an implantable device having a substrate and at least one electrode, the electrode having at least one aperture through which material of the substrate extends to anchor the electrode to the substrate. Other disclosed features relate to a foldable anchor device, a curved electrode substrate and depth markers, for example.
The present disclosure relates to a peripheral nerve electrode array that includes a first, second and third pair of electrodes spaced from each other along a longitudinal axis of the electrode array, the second pair of electrodes being located between the first and third pairs of electrodes. The present disclosure further relates to method for treating or preventing a chronic inflammatory condition in a human subject in need thereof, comprising providing to the human subject a therapeutically effective electrical stimulation of the anterior central abdominal vagus nerve or the posterior central abdominal vagus nerve, wherein the electrical stimulation is provided through two or more previously implanted electrodes at a site below the cardiac branches and above the hepatic-celiac branches of the nerve; and whereby the chronic inflammatory condition is prevented or treated in the human subject. In addition, the present disclosure relates to a method for treating or preventing a chronic inflammatory condition in a human subject in need thereof.
16 - Paper, cardboard and goods made from these materials
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medical apparatus and instruments; electronic medical
apparatus; medical diagnostic devices and instruments;
medical devices and instruments for monitoring and treating
health and medical conditions; medical implants; wearable
medical devices; hearing aids; apparatus for use in
alleviating hearing disorders; apparatus for use in treating
hearing disorders; apparatus for use in the diagnosis,
monitoring and treatment of neurological conditions and
central nervous system disorders, including parkinson's
disease and epilepsy; sensors (measurement apparatus) for
medical use. Printed matter; printed publications; printed journals;
printed newsletters and magazines; all the aforementioned
being in relation to medical research and medical matters. Medical research; medical research in the field of
neurological conditions and central nervous system
disorders; medical research in the field of parkinson's
disease; medical research in the field of epilepsy; medical
research in the field of hearing disorders; technological
research and design in the field of medical devices,
apparatus and instruments; design and development of
computer hardware, computer firmware and computer software
for use in the medical field; software as a service (saas)
for use in the medical field; platforms as a service (paas)
for use in the medical field; computer firmware and computer
software for use in the medical field.
Embodiments generally relate to a method of assessing the hearing of a patient using functional near-infrared spectroscopy (fNIRS). The method comprises receiving at least one response signal from an optode placed on a scalp of the patient, the response signal comprising fNIRS data generated by the optode and relating to an aural stimulation received by the patient; comparing at least one parameter of the at least one response signal to a predetermined parameter value; and determining an auditory response of a patient based on the at least one parameter of the at least one response signal.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
16 - Paper, cardboard and goods made from these materials
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medical apparatus and instruments, namely, medical apparatus and instruments for use in neuromodulation and medical apparatus and instruments for the diagnosis, monitoring, management and treatment of hearing disorders; electronic medical apparatus, namely, electronic medical apparatus for use in neuromodulation and the electronic medical apparatus for the diagnosis, monitoring, management and treatment of hearing disorders; medical diagnostic devices and instruments, namely, medical diagnostic devices and instruments for use in neuromodulation and medical diagnostic devices and instruments for the diagnosis, monitoring, management and treatment of hearing disorders; medical devices and instruments for monitoring and treating health and medical conditions, namely, medical devices and instruments for monitoring and treating health and medical conditions by way of neuromodulation and medical devices and instruments for monitoring and treating health and medical conditions, namely, hearing disorders; medical implants, namely, medical implants for use in neuromodulation and medical implants for the diagnosis, monitoring, management and treatment of hearing disorders, all being made from artificial materials; wearable medical devices, namely, wearable medical devices for use in neuromodulation and wearable medical devices for the diagnosis, monitoring, management and treatment of hearing disorders; hearing aids; apparatus for use in alleviating hearing disorders, namely, hearing aids and cochlea implants made of artificial materials; apparatus for use in treating hearing disorders, namely, hearing aids and cochlear implants made of artificial materials; apparatus for use in the diagnosis, monitoring and treatment of neurological conditions and central nervous system disorders, namely, hearing disorders; sensors being measurement apparatus for medical use, namely, biofeedback sensors Printed matter, namely, books, journals, magazines and brochures in the field of medical research and medical practice; printed publications, namely, books, journals, magazines and brochures in the field of medical research and medical practice; printed journals in the field of medical research and medical practice; printed newsletters and magazines in the field of medical research and medical practice; all the aforementioned being in relation to medical research and medical matters Medical research; medical research in the field of neurological conditions and central nervous system disorders; medical research in the field of Parkinson's disease; medical research in the field of epilepsy; medical research in the field of hearing disorders; technological research and design in the field of medical devices, apparatus and instruments; technological research and design of computer hardware, firmware and software for use in the medical field; software as a service (SaaS) featuring software, hosting online non-downloadable software for use in the medical field, namely, for use with medical devices for the diagnosis, monitoring, management and treatment of health and medical conditions; Platforms as a Service (Paas) for use in the medical field, namely, providing online non-downloadable software for use with medical devices for the diagnosis, monitoring, management and treatment of health and medical conditions; providing online non-downloadable computer firmware and computer software for use in the medical field, namely, for use with medical devices for the diagnosis, monitoring, management and treatment of health and medical conditions
Medical apparatus and instruments; medical hearing
instruments; sensors (measurement apparatus) for medical
use; electronic medical apparatus; medical diagnostic
devices and instruments; medical devices and instruments for
monitoring and treating health and medical conditions;
medical implants; wearable medical devices; apparatus for
use in the monitoring and treatment of hearing disorders;
medical instruments for use as aids to hearing; hearing
aids.
Medical apparatus and instruments; electronic medical
apparatus; medical diagnostic devices and instruments;
medical devices and instruments for monitoring and treating
health and medical conditions; medical implants; wearable
medical devices; apparatus for use in the diagnosis,
monitoring and treatment of neurological conditions and
central nervous system disorders, including parkinson's
disease; sensors (measurement apparatus) for medical use.
29.
METHODS AND SYSTEMS FOR DETERMINING HEARING THRESHOLDS
Embodiments generally relate to a method of determining a hearing threshold value for a subject. The method comprises receiving at least one first response signal relating to an aural stimulation experienced by the subject at a first intensity level; receiving at least one second response signal relating to an aural stimulation experienced by the subject at a second intensity level, wherein the second intensity level is below an expected hearing threshold for the subject; calculating at least one first value relating to the at least one first response signal; calculating a second value relating to the at least one second response signal; plotting the at least one first value against the first intensity level on a plot; calculating a regression curve that fits the plot; and determine the hearing threshold of the subject to be the intensity level that corresponds to the second value along the regression curve.
Medical apparatus and instruments for the monitoring and treatment of hearing disorders; medical hearing instruments; sensors for medical use, namely, patient monitoring sensors; electronic medical apparatus for the monitoring and treatment of hearing disorders; medical diagnostic devices and instruments for diagnosing hearing disorders; medical devices and instruments for monitoring and treating hearing disorders; medical implants, namely, devices composed of artificial materials for the treatment of hearing disorders; wearable medical devices for the monitoring and treatment of hearing disorders; medical apparatus for use in the monitoring and treatment of hearing disorders; medical instruments for use as aids to hearing; hearing aids
Medical apparatus and instruments for the monitoring and treatment of neurological conditions and central nervous system disorders, namely, Parkinson's disease; electronic medical apparatus for the monitoring and treatment of neurological conditions and central nervous system disorders, namely, Parkinson's disease; medical diagnostic devices and instruments for diagnosing neurological conditions and central nervous system disorders, namely, Parkinson's disease; medical devices and instruments for monitoring and treating neurological conditions and central nervous system disorders, namely, Parkinson's disease; medical implants, namely, devices composed of artificial materials for the monitoring and treatment of neurological conditions and central nervous system disorders, namely, Parkinson's disease; wearable medical devices for the monitoring and treatment of neurological conditions and central nervous system disorders, namely, Parkinson's disease; sensors for medical use, namely, patient monitoring sensors for the monitoring of Parkinson's disease; all the aforementioned being for use in the diagnosis, monitoring, management and treatment of neurological conditions and central nervous system disorders, namely, epilepsy, seizure control, dementia, Alzheimer's disease and for brain machine interfacing, namely, neural control of artificial limb prosthetics; all the aforementioned being for use on humans; none of the aforementioned being in relation to pulmonary respiration or ventilation, or body composition analysers; apparatus for use in the diagnosis, monitoring and treatment of neurological conditions and central nervous system disorders, namely, Parkinson's disease
The present invention relates to methods of treating an auditory disorder. In particular, the present invention relates to treating an auditory disorder using supraparticles comprising a therapeutic payload.
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
Systems and Methods for Monitoring Neural Activity A method of monitoring neural activity responsive to a stimulus in a brain or a subject under general anaesthetic, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.
A system, method and device for characterising a joint between a first body region and a second body region is disclosed. The system may comprise a reference portion configured to be coupled to the first body region, a movable portion configured to be coupled to the second body region and a movement source configured to move the movable portion relative to the reference portion, such as in a direction of the joint. A set of one or more sensors may collect a set of one or more measurements related to the movement between the reference portion and the moveable portion, for example to determine a force between the movable portion and the body region coupled thereto, and/or a power consumed by the movement source. The measurements may be used to characterise the joint, such as by determining a rigidity of the joint.
Detecting of a disorder associated with impaired barrier function in the gastrointestinal tract of a subject is described, including through determining bioimpedance across a subject's gastrointestinal tract wall and detecting impaired barrier function based on bioimpedance. An electrical signal is measured between first and second electrodes, at least the first electrode being located in a gastrointestinal tract of the body and one or more characteristics are determined based on the measured electrical signal. The one or more characteristics can comprise hallmarks of impaired barrier function such as leakiness and/or permeability of the gastrointestinal tract and can provide an indication of inflammatory bowel disease and/or gut inflammation.
The present disclosure relates to a peripheral nerve electrode array that includes a first, second and third pair of electrodes spaced from each other along a longitudinal axis of the electrode array, the second pair of electrodes being located between the first and third pairs of electrodes. The present disclosure further relates to method for treating or preventing a chronic inflammatory condition in a human subject in need thereof, comprising providing to the human subject a therapeutically effective electrical stimulation of the anterior central abdominal vagus nerve or the posterior central abdominal vagus nerve, wherein the electrical stimulation is provided through two or more previously implanted electrodes at a site below the cardiac branches and above the hepatic-celiac branches of the nerve; and whereby the chronic inflammatory condition is prevented or treated in the human subject. In addition, the present disclosure relates to a method for treating or preventing a chronic inflammatory condition in a human subject in need thereof.
An anchor device is described that is adapted to support one or more conductors extending out of an opening in an outer surface of an eye, from a device implanted in the eye to a communications interface. The anchor device comprises a conductor receiving portion including a channel, the conductors being positionable through the channel; and a fixation portion connected to the conductor receiving portion, the fixation portion being adapted to be secured to the outer surface of the eye. The conductor receiving portion is configured to allow movement of the channel and/or conductors relative to the fixation portion. A visual prosthesis comprising the anchor device is also described, along with apparatus and methods for positioning the visual prosthesis or other types of implantable electrical apparatus.
The present invention relates to methods of treating an auditory disorder. In particular, the present invention relates to treating an auditory disorder using supraparticles comprising a therapeutic payload.
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
The present disclosure relates to improved supraparticles loaded with high levels of payload and methods for their production. Such supraparticles may be used in a range of therapeutic applications, for example, to improve growth or survival of cells and/or treat disease.
Embodiments generally relate to a method of assessing the hearing of a patient using functional near-infrared spectroscopy (fNIRS). The method comprises receiving at least one response signal from an optode placed on a scalp of the patient, the response signal comprising fNIRS data generated by the optode and relating to an aural stimulation received by the patient; comparing at least one parameter of the at least one response signal to a predetermined parameter value; and determining an auditory response of a patient based on the at least one parameter of the at least one response signal.
A method for monitoring neural activity responsive to a stimulus in a brain, the method comprising: a. applying a first stimulus to one or more of at least one electrode implanted in the brain, the first stimulus comprising a first plurality of bursts of stimulation, b. detecting high frequency oscillations (HFOs) between about 200 Hz and about 500 Hz due to neuronal activity at one or more of the at least one electrode implanted in the brain at least partially during application of the first stimulus; c. determining one or more waveform characteristics of the HFOs; and d. generating a second stimulus comprising a second plurality of bursts of stimulation, wherein one or more waveform characteristics of the second stimulus is dependent on the one of more waveform characteristics of the HFOs; and e. applying the second stimulus to one or more of the at least one electrode implanted in the brain.
An electrode device is disclosed that is removably implantable at least partially in a bone or other tissue. The electrode device includes a head and a shaft connected to the head. The shaft has a shaft body extending distally from the head in an axial direction of the shaft, and a conductive element including a conductive surface at a distal end of the shaft. A plurality of discrete anchor elements can project from an outer surface of the shaft body in a transverse direction of the shaft. A conductive wire can be permanently fixed to a proximal end surface of the conductive element, the end surface being located in or adjacent the head. The head can have a convex outer surface and a concave inner surface. An electrode array and a reamer tool is also disclosed.
Detecting of a disorder associated with impaired barrier function in the gastrointestinal tract of a subject is described, including through determining bioimpedance across a subject's gastrointestinal tract wall and detecting impaired barrier function based on bioimpedance. An electrical signal is measured between first and second electrodes, at least the first electrode being located in a gastrointestinal tract of the body and one or more characteristics are determined based on the measured electrical signal. The one or more characteristics can comprise hallmarks of impaired barrier function such as leakiness and/or permeability of the gastrointestinal tract and can provide an indication of inflammatory bowel disease and/or gut inflammation.
An electrode device is disclosed comprising: an elongate, implantable body comprising elastomeric material, a plurality of electrodes positioned along a length of the implantable body; an electrical connection comprising one or more conductive elements extending through the elastomeric material and electrically connecting to the electrodes; and a reinforcement device extending through the elastomeric material. The length of the implantable body is extendible by placing the implantable body under tension. The reinforcement device limits the degree by which the length of the implantable body can extend under tension. At least one of the electrodes can extend circumferentially around a portion of the implantable body. A delivery device and method of delivery for an electrode device is also disclosed.
A method of monitoring neural activity responsive to a stimulus in a brain, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.
The present disclosure relates to visual prosthesis apparatus including an implantable device having a substrate and a plurality of electrodes located in or on the substrate, the substrate adapted to be implanted at least partially in an eye of a patient. A first inductor is included in the implantable device, for example by encapsulating an inductor coil in the substrate or on an associated lead or anchor device. In some instances, the electrodes in the substrate may partially provide the first inductor. A second inductor is adapted to locate externally to the eye and inductively couple with the first inductor. A processor is adapted to determine a direction of movement of the eye based on changes in electrical current induced in one of the first and second inductors due to relative movement of the first and second inductors.
Some embodiments relate to a method of adjusting therapeutic stimulation from a therapeutic stimulation system. The method comprising: providing therapeutic stimulation based on a plurality of stimulation parameters to a patient with an implanted controller and at least two electrodes; receiving data indicative of feedback associated with a patient rating of the therapeutic stimulation via a patient input device; automatically adjusting, with the implanted controller, at least one of the plurality of stimulation parameters; and providing adjusted therapeutic stimulation based on the adjusted at least one stimulation parameter to the patient with the controller and the at least two electrodes. The method further comprises receiving additional data indicative of feedback associated with another patient rating of the adjusted therapeutic stimulation; and executing a machine learning algorithm based on the stimulation parameters and received data indicative of feedback, to determine preferred stimulation parameters.
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
G05B 13/00 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion
48.
Electrical apparatus and methods and apparatus for positioning and implanting components thereof
An anchor device is described that is adapted to support one or more conductors extending out of an opening in an outer surface of an eye, from a device implanted in the eye to a communications interface. The anchor device comprises a conductor receiving portion including a channel, the conductors being positionable through the channel; and a fixation portion connected to the conductor receiving portion, the fixation portion being adapted to be secured to the outer surface of the eye. The conductor receiving portion is configured to allow movement of the channel and/or conductors relative to the fixation portion. A visual prosthesis comprising the anchor device is also described, along with apparatus and methods for positioning the visual prosthesis or other types of implantable electrical apparatus.
Embodiments relate to a device for controlling delivery of stimulation signals, comprising: a stimulation delivery circuit; a monitoring component to monitor voltage supplied in at least one current-driven charge pulse via the stimulation delivery circuit; and a stimulation control component to control voltage supplied in at least one subsequent charge pulse based on the charge of the at least one charge pulse delivered by the stimulation delivery circuit. The device may further comprise a model generation component to generate an impedance model of stimulation electrodes in the stimulation delivery circuit, wherein the stimulation control component is configured to control the stimulation delivery circuit to deliver charge according to the impedance model.
Some embodiments relate to a device for generating stimulation signals, comprising: a stimulation delivery circuit; a first component to monitor charge delivered in at least one charge pulse via the stimulation delivery circuit; and a second component to ensure delivered charge substantially corresponds to charge of a charge pulse intended to be delivered by the stimulation delivery circuit. In some embodiments, the device may further comprise a charge setting circuit responsive to a charge pulse setting signal, such as a constant current of fixed pulse width, to set the charge of the charge pulse intended to be delivered.
Visual prosthesis apparatus includes an image receiver, a processor coupled to the image receiver, a stimulation device coupled to the processor, and an eye monitoring device coupled to the processor. The image receiver receives a sequence of images and the processor produces a stimulation signal at least partially in accordance with the received images. The stimulation device receives the stimulation signal and stimulates visual neurons of a user accordingly to provide the user with a visual percept. The eye monitoring device monitors one or more ocular parameters at an eye region of the user, wherein one or more control functions are associated with the monitored ocular parameters. The processor controls the visual prosthesis apparatus in accordance with the monitored ocular parameters and the associated control functions. The one or more ocular parameters can include pupil size, state of closure of the user's eyelid and direction of eye gaze.
An anchor device is described that is adapted to support one or more conductors extending out of an opening in an outer surface of an eye, from a device implanted in the eye to a communications interface. The anchor device comprises a conductor receiving portion including a channel, the conductors being positionable through the channel; and a fixation portion connected to the conductor receiving portion, the fixation portion being adapted to be secured to the outer surface of the eye. The conductor receiving portion is configured to allow movement of the channel and/or conductors relative to the fixation portion. A visual prosthesis comprising the anchor device is also described, along with apparatus and methods for positioning the visual prosthesis or other types of implantable electrical apparatus.
A prosthesis is provided comprising a substrate having a distal end and a proximal end; and a plurality of electrodes located at or adjacent the distal end of the substrate. The distal end of the substrate is configured for insertion, via an incision, between first and second tissue layers, such as the sclera and choroid in the eye. The prosthesis tapers in thickness towards the distal end and has a substantially curved profile at least on one surface so that the prosthesis can be inserted into position without needing a guide and without causing damage to the tissue or the prosthesis. The prosthesis can include an electrode interface unit located at or adjacent the proximal end of the substrate which locates between the tissue layers. An anchor portion can be provided that extends from the substrate into the incision.
Visual prosthesis apparatus includes an image receiver, a processor coupled to the image receiver, a stimulation device coupled to the processor, and an eye monitoring device coupled to the processor. The image receiver receives a sequence of images and the processor produces a stimulation signal at least partially in accordance with the received images. The stimulation device receives the stimulation signal and stimulates visual neurons of a user accordingly to provide the user with a visual percept. The eye monitoring device monitors one or more ocular parameters at an eye region of the user, wherein one or more control functions are associated with the monitored ocular parameters. The processor controls the visual prosthesis apparatus in accordance with the monitored ocular parameters and the associated control functions. The one or more ocular parameters can include pupil size, state of closure of the user's eyelid and direction of eye gaze.
A method and apparatus is described for electrically stimulating a patient's retina with an electrode array (32) implanted in the patient's eye, wherein one or more images are captured; at least one line and/or edge in the images is determined (21), a line of electrodes in the electrode array corresponding to a detected line and/or edge is identified (24); and electrical current is applied simultaneously to electrodes of the identified line of electrodes.
Embodiments relate to a device for controlling delivery of stimulation signals, comprising: a stimulation delivery circuit; a monitoring component to monitor voltage supplied in at least one current-driven charge pulse via the stimulation delivery circuit; and a stimulation control component to control voltage supplied in at least one subsequent charge pulse based on the charge of the at least one charge pulse delivered by the stimulation delivery circuit. The device may further comprise a model generation component to generate an impedance model of stimulation electrodes in the stimulation delivery circuit, wherein the stimulation control component is configured to control the stimulation delivery circuit to deliver charge according to the impedance model.
Some embodiments relate to a device for generating stimulation signals, comprising: a stimulation delivery circuit; a first component to monitor charge delivered in at least one charge pulse via the stimulation delivery circuit; and a second component to ensure delivered charge substantially corresponds to charge of a charge pulse intended to be delivered by the stimulation delivery circuit. In some embodiments, the device may further comprise a charge setting circuit responsive to a charge pulse setting signal, such as a constant current of fixed pulse width, to set the charge of the charge pulse intended to be delivered.
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (Australia)
Inventor
O'Shea, Michael, Shane
Graichen, Florian, Hans, Maximilian
Tait, Russell, John
Donohue, Andrew, Craig
Ng, Sarah, Man, Ye
D'Souza, Asha, Marina
Abstract
The present invention relates in general to polymer-drug conjugates. In particular, the invention relates to polymer-drug conjugates wherein the conjugated drugs are selected from prostaglandins and substituted prostaglandins, to a method of delivering such prostaglandin drugs to a subject, to a sustained drug delivery system comprising the polymer-drug conjugates, to a method of preparing the polymer-drug conjugates, and to an implant comprising the polymer-drug conjugates. The polymer-drug conjugates may be useful for delivering prostaglandins and substituted prostaglandins for the treatment of glaucoma.
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C07C 405/00 - Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
59.
Apparatus for stimulating and/or monitoring activity in tissue
A prosthesis is provided comprising a substrate having a distal end and a proximal end; and a plurality of electrodes located at or adjacent the distal end of the substrate. The distal end of the substrate is configured for insertion, via an incision, between first and second tissue layers, such as the sclera and choroid in the eye. The prosthesis tapers in thickness towards the distal end and has a substantially curved provide profile at least on one surface so that the prosthesis can be inserted into position without needing a guide and without causing damage to the tissue or the prosthesis. The prosthesis can include an electrode interface unit located at or adjacent the proximal end of the substrate which locates between the tissue layers. An anchor portion can be provided that extends from the substrate into the incision.
A device and method for counteracting seizure events in a mammalian brain is described in which a plurality of electrodes are configured to deliver pulsatile electrical stimulus to the brain. The pulses are applied across the electrodes asynchronously. At each electrode, the pulses can be periodic or aperiodic. The pulse width may be greater than 300 μsec
Hearing apparatus is provided comprising one or more audio input devices (10a, 10b); and signal processing apparatus (2) configured to: receive an audio signal from the audio input devices, the audio signal corresponding to a mixed sound signal generated by a plurality of sound sources; separate the audio signal into a plurality of subcomponent electrical audio signals, each subcomponent electrical audio signal corresponding to a part of the mixed sound signal generated by a subset of the plurality of sound sources; and deliver each subcomponent electrical audio signal to a selected one of a plurality of hearing devices (31, 32) of a recipient, the selection of the hearing device for each subcomponent electrical audio signal being based on one or more characteristics of the subcomponent electrical audio signal. One or more perceptual properties of the subcomponent electrical audio signals may be enhanced to promote better perceptual segregation by the listener.
A method and apparatus is described for electrically stimulating a patient's retina with an electrode array (32) implanted in the patient's eye, wherein one or more images are captured; at least one line and/or edge in the images is determined (21), a line of electrodes in the electrode array corresponding to a detected line and/or edge is identified (24); and electrical current is applied simultaneously to electrodes of the identified line of electrodes.
Neural stimulation is effected by a stimulus current pulse. The current pulse is initially of an amplitude to rapidly induce a desired electrode voltage, and is subsequently of reduced amplitude to control electrode voltage in a desired manner. This can effect a reduced peak electrode voltage while delivering a given amount of charge. Optimization of the current pulse may further involve parameterising an electrode current waveform as a sequence of piecewise constant steps, each step having substantially the same duration as all other steps and each step having a calculatable amplitude, and identifying electrode-tissue interface (ETI) parameters. For each step of the pulse, the respective step amplitude is then calculated using the identified ETI parameters to optimise the electrode voltage.
A prosthesis is provided comprising a substrate having a distal end and a proximal end; and a plurality of electrodes located at or adjacent the distal end of the substrate. The distal end of the substrate is configured for insertion, via an incision, between first and second tissue layers, such as the sclera and choroid in the eye. The prosthesis tapers in thickness towards the distal end and has a substantially curved provide profile at least on one surface so that the prosthesis can be inserted into position without needing a guide and without causing damage to the tissue or the prosthesis. The prosthesis can include an electrode interface unit located at or adjacent the proximal end of the substrate which locates between the tissue layers. An anchor portion can be provided that extends from the substrate into the incision.
The present invention provides a method for counteracting seizure events in a mammalian brain, the method comprising applying an electrical stimulus to the brain, the electrical stimulus being pulsatile and comprising pulses forming a pulse train. In order to effectively "desynchronize" the neural activity patterns in the brain, the pulse train can be at a frequency greater than substantially 300 Hz and at a duty cycle greater than substantially 20%, the pulse train can have an inconstant inter pulse interval such that the pulse rate is not constant throughout the pulse train, and the pulses can have a pulse width greater than substantially 300 µsec. Apparatus for carrying out the method is also described.
Centre for Eye Research Australia Limited (Australia)
Inventor
Ng, David, Cheekeong
Bai, Shun
Skafidas, Efstratios
Allen, Penelope
Williams, Chris
Meffin, Hamish
Mccombe, Mark
Halpern, Mark
Boyd, Clive, Stewart
Abstract
The present invention relates to retinal prostheses, and in particular to the transfer of electrical power and data from outside of the human body to such a prosthesis. The retinal prosthesis comprises: A retinal electrode array implanted in the eye to stimulate the retina. A receiving coil implanted sub-sclerally to inductively receive power or data signals, or both. An electrical connection between the implanted receiving coil and the implanted retinal electrode array. Wherein the receiving coil is flexible and able to conform to scleral curvature, when it is implanted. And wherein power or data signals, or both, received by the receiving coil from a remote transmitting coil are automatically provided to the electrode array. According to a second aspect, the present invention provides a method for implanting a retinal prosthesis. In a further aspect the present invention further provides an ocular implant.
In one aspect of the invention, a cochlear implant constructed and arranged to successively generate stimulation signals each comprising at least one stimulus pulse such that said successive stimulation signals incrementally build a neural excitation pattern that accurately reflects a received sound. In one embodiment, each said successive stimulation signal is generated based on the cumulative effect of all previous stimulus pulses, thereby compensating for finite spatial spreading of individual stimulus pulses as well as for the temporal integration of the neural excitation pattern along the neural pathways.
A61F 11/04 - Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense, e.g. through the touch sense
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
