The disclosure provides systems and methods for data analysis of experimental data. The analysis can include reference data that are not directly generated from the present experiment, which reference data may be values of the experimental parameters that were either provided by a user, computed by the system with input from a user, or computed by the system without using any input from a user. Another example of such reference data may be information about the instrument, such as the calibration method of the instrument.
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded computer software, namely, software framework for planning, implementing, controlling, monitoring, analyzing, and reproducing laboratory experiments; Recorded computer software, namely, software for providing instructions for conducting customizable scientific experiments; Recorded computer program, namely, a function-based programming interface for use in controlling remote laboratory equipment
3.
System and method for management, execution, and analysis of laboratory experiments
The disclosure provides systems and methods for conducting and managing integrated laboratory experiments. The system includes a variety of laboratory instruments that are connected to conduct a large number of different types of experiments, and an interface for a user to design experiments and adjust parameters for the experiments. Given the integration, the system can further take data from related samples and instruments for determining or adjusting certain experimental parameters for optimized experimental efficiency and results.
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
Provided are nucleic acid translators capable of carrying out logic operations with improved efficiency, maximized output and reduced off-target effects, in particular in a biological system. Methods of using these translators to transduce signal are also provided.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
G06N 3/00 - Computing arrangements based on biological models
B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
G06N 3/12 - Computing arrangements based on biological models using genetic models
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cloud computing for remote medical laboratories featuring software for use in monitoring laboratory equipment and recording data; Cloud computing for remote scientific laboratories featuring software for use in monitoring laboratory equipment and recording data; Cloud computing for remote laboratory experiments on behalf of others featuring software for use in monitoring laboratory equipment and recording data; software as a service featuring software for use in data processing for remote laboratory experiments, for running remote laboratory experiments, for reviewing remote laboratory experiment controls, equipment, and environment data, and for reviewing remote laboratory experiment results; software as a service featuring software for use in data processing for computer simulations of remote laboratory experiments and for computer simulations of biological and chemical phenomena and systems; cloud computing featuring software for use in data processing for remote scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; cloud computing featuring software for use in data processing for biopharmaceutical research design and scientific testing services; cloud computing featuring software for use in data processing for product safety and quality assurance testing for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; cloud computing featuring software for use in data processing for remote toxicological safety and quality assurance testing for pharmaceuticals, chemicals, and consumer products; cloud computing featuring software for use in indexing, storage, and searching of information relating to remote laboratory experiment controls, equipment, environment data, and experiment results as well as information relating to computer simulations of laboratory experiments and biological and chemical phenomena and systems; software as a service featuring software for creation and processing of un-structured, semi-structured, and structured information relating to laboratory experiments and computer simulations of laboratory experiments and biological and chemical phenomena and systems; software as a service featuring software for use in developing, executing, monitoring, and managing enterprise resource planning, manufacturing execution systems, and connected factories
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cloud computing for medical laboratories featuring software for use for monitoring laboratory equipment and recording data and electronic data storage services; Cloud computing for scientific laboratories featuring software for use in monitoring laboratory equipment and recording data and electronic data storage services; Cloud computing for laboratory experiments on behalf of others featuring software for use in monitoring laboratory equipment and recording data; software as a service featuring software for use in data processing for laboratory experiments, for running laboratory experiments, for reviewing laboratory experiment controls, equipment, and environment data, and for reviewing laboratory experiment results and electronic data storage services; software as a service featuring software for use in data processing for computer simulations of laboratory experiments and for computer simulations of biological and chemical phenomena and systems and electronic data storage services; cloud computing featuring software for use in data processing and electronic data storage for scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; cloud computing featuring software for use in data processing for product safety and quality assurance testing for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; cloud computing featuring software for use in data processing for toxicological safety and quality assurance testing for pharmaceuticals, chemicals, and consumer products; cloud computing featuring software for use in indexing, storage, and searching of information relating to laboratory experiment controls, equipment, environment data, and experiment results as well as information relating to computer simulations of laboratory experiments and biological and chemical phenomena and systems; software as a service featuring software for use in creation, processing, and storage of un-structured, semi-structured, and structured information relating to laboratory experiments and computer simulations of laboratory experiments and biological and chemical phenomena and systems; software as a service featuring software for use in developing, executing, monitoring, and managing enterprise resource planning, experimental logistics, manufacturing execution systems, and connected factories
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medical laboratory services; scientific laboratory services; conducting scientific laboratory experiments remotely in the fields of pharmaceutical, biotechnology, and materials science research; software as a service featuring software for designing laboratory experiments, for running laboratory experiments, for analyzing laboratory experiment controls, equipment, and environment data, and for analyzing laboratory experiment results; remote scientific testing services of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; biopharmaceutical research design and scientific testing services; product safety and quality assurance testing services for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; toxicological safety and quality assurance testing services for pharmaceuticals, chemicals, and consumer products; software as a service featuring software for developing, executing, monitoring, and managing enterprise resource planning, experimental logistics, manufacturing execution systems, and connected factories; software as a service featuring software for running computer simulations of laboratory experiments, for running computer simulations of biological and chemical phenomena and systems, for optimizing laboratory experiment parameters with computational methods, and for comparison of computer simulations against empirically observed laboratory experiment results; software as a service featuring software for providing regulatory compliance documentation following experiments, for performing regulatory agencies audits following experiments, and for performing internal audits following experiments; software as a service featuring software for processing of un-structured, semi-structured, and structured information relating to laboratory experiments and computer simulations of laboratory experiments and biological and chemical phenomena and systems
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medical laboratory cloud computing services featuring software for conducting laboratory experiments; scientific laboratory cloud computing services featuring software for conducting laboratory experiments; cloud computing services featuring software for conducting laboratory experiments on behalf of others; software as a service featuring cloud computation data processing software for use in laboratory experiments, for running laboratory experiments, for reviewing laboratory experiment controls, equipment, and environment data, and for reviewing laboratory experiment results; cloud computing services featuring software for use in data processing for scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; cloud computing services featuring software for use in data processing for biopharmaceutical research design and scientific testing services; cloud computing services featuring software for use in data processing for product safety and quality assurance testing for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; cloud computing services featuring software for use in data processing for toxicological safety testing for pharmaceuticals, chemicals, and consumer products; cloud computing services featuring software for use in services for running computer simulations to simulate laboratory experiments and biological and chemical phenomena and systems
42 - Scientific, technological and industrial services, research and design
Goods & Services
Software as a service featuring software for designing laboratory experiments, for running laboratory experiments, and for reviewing laboratory experiment controls, equipment, and environmental data ; software as a service featuring software for reviewing laboratory experiment results; software as a service featuring software for research and development of chemicals, pharmaceuticals, biologics, and vaccines; software as a service featuring software for scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; software as a service featuring software for biopharmaceutical research design and scientific testing services; software as a service featuring software for product safety testing for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; software as a service featuring software for toxicological safety testing services for pharmaceuticals, chemicals, and consumer products; software as a service for developing quality control and custom assays; software as a service for remotely deploying quality control and custom assays; software as a service for remotely managing the performance of quality control and custom assays; software as a service featuring software for running computer simulations of laboratory experiments, for running computer simulations of biological and chemical phenomena and systems, for optimizing laboratory experiment parameters with computational methods, and for comparison of computer simulations against empirically observed laboratory experiment results; and software as a service for providing regulatory compliance documentation following experiments, for performing regulatory agencies audits following experiments, and for performing internal audits following experiments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Monitoring medical laboratory services namely monitoring of computer systems and monitoring of laboratory equipment for quality control purposes; monitoring scientific laboratory services namely monitoring of computer systems and monitoring of laboratory equipment for quality control purposes; monitoring laboratory experiments conducted on behalf of others for quality control purposes; software as a service featuring software for monitoring laboratory experiments and environment data; monitoring of scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; biopharmaceutical research and scientific testing in the field of biopharmaceuticals; monitoring product safety and quality assurance testing for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; monitoring toxicological safety testing services for pharmaceuticals, chemicals, and consumer products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medical laboratory services; scientific laboratory services; conducting laboratory experiments on behalf of others; software as a service featuring software for use in running, controlling, and recording laboratory equipment operations for laboratory equipment and providing instructions for human laboratory equipment operators in connection with scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; biopharmaceutical research services, and scientific testing equipment control services, namely, running and controlling laboratory equipment and recording laboratory equipment operations for quality control purposes; software as a service featuring software for running, controlling and recording laboratory equipment operations for laboratory equipment and providing instructions for human laboratory equipment operators in connection with troubleshooting, maintaining, and repairing laboratory experiments and laboratory equipment; software as a service featuring software for capturing experimental data and associated environmental data
37 - Construction and mining; installation and repair services
42 - Scientific, technological and industrial services, research and design
Goods & Services
troubleshooting in the nature of repairing laboratory experiment apparatus and hardware for scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; troubleshooting in the nature of repairing laboratory experiment hardware and apparatus for product safety; troubleshooting in the nature of repairing laboratory experiments for toxicological safety; troubleshooting in the nature of repairing laboratory experiments for quality assurance Medical laboratory services; scientific laboratory services; software as a service featuring software for conducting troubleshooting, repairs, and maintenance of laboratory equipment and improving settings of laboratory equipment on behalf of others; software as a service featuring software for troubleshooting and repairing laboratory experiments, and for improving settings of laboratory equipment; troubleshooting in the nature of diagnosing problems with laboratory experiment software and hardware and repairing laboratory experiment software for scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; biopharmaceutical research design and scientific testing services; troubleshooting in the nature of diagnosing problems with laboratory experiment software and hardware and repairing laboratory experiment software for product safety and quality assurance testing for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; troubleshooting in the nature of diagnosing problems with laboratory experiment software and hardware and repairing laboratory experiment software for toxicological safety and quality assurance testing services for pharmaceuticals, chemicals, and consumer product; software as a service featuring software for communicating with end users regarding troubleshooting and repairing of laboratory equipment and laboratory experiments; providing online, non-downloadable software for providing customer service regarding laboratory experiments conducted on behalf of others
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing temporary use of online non-downloadable software for cloud based computing for remote medical laboratory services; Providing temporary use of online non-downloadable software for cloud based remote scientific laboratory services; Providing temporary use of online non-downloadable software for conducting remote laboratory experiments on behalf of others; software as a service featuring software for use in remotely running, controlling, and recording laboratory equipment operations for laboratory equipment and providing instructions for human laboratory equipment operators in connection with scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; Providing temporary use of online non-downloadable software for cloud based remote biopharmaceutical research design and scientific testing equipment control services namely remotely performing biopharmaceutical experiments; software as a service (SAAS) services featuring software for use in remotely running, controlling and recording laboratory equipment operations for laboratory equipment and providing instructions for human laboratory equipment operators in connection with troubleshooting, maintaining, and repairing remote laboratory experiments and laboratory equipment; cloud based software as a service (SAAS) services featuring software for use in capturing remote experimental data and associated environmental data
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cloud based remote monitoring of medical laboratory services namely monitoring of computer systems and monitoring of laboratory equipment for quality control purposes; cloud based remote monitoring scientific laboratory services namely monitoring of computer systems and monitoring of laboratory equipment for quality control purposes; cloud based remote monitoring laboratory experiments conducted on behalf of others for quality control purposes; cloud based software as a service featuring software for remote monitoring laboratory experiments and environment data; cloud based remote monitoring of scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; cloud based remote biopharmaceutical research and scientific testing in the field of biopharmaceuticals; cloud based remote monitoring product safety and quality assurance testing for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; cloud based remote monitoring toxicological safety testing services for pharmaceutical, chemicals, and consumer products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medical laboratory services; scientific laboratory services; software as a service featuring software for use in conducting troubleshooting, repairs, and maintenance of laboratory equipment and improving settings of laboratory equipment on behalf of others; software as a service featuring software for troubleshooting and repairing laboratory experiments, and for improving settings of laboratory equipment; troubleshooting and repairing laboratory experiments namely troubleshooting and updating of computer software and diagnosing problems with laboratory equipment for scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; biopharmaceutical research design and scientific testing in the field of biopharmaceuticals; troubleshooting and repairing laboratory experiments namely troubleshooting and updating of computer software and diagnosing problems with laboratory equipment for product safety and quality assurance testing for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; troubleshooting and repairing laboratory experiments namely troubleshooting and updating of computer software and diagnosing problems with laboratory equipment for toxicological safety and quality assurance testing services for pharmaceuticals, chemicals, and consumer product; software as a service featuring software for use in communicating with end users regarding troubleshooting and repairing of laboratory equipment and laboratory experiments; software as a service featuring software for use in providing customer service regarding laboratory experiments conducted on behalf of others
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing temporary use of online non-downloadable software for remote medical laboratory services; Providing temporary use of online non-downloadable software for remote scientific laboratory services; Providing temporary use of online non-downloadable software for remotely conducting laboratory experiments; software as a service (SAAS) services featuring software for remotely designing laboratory experiments, for running laboratory experiments, for analyzing laboratory experiment controls, equipment, and environment data, and for analyzing laboratory experiment results; Providing temporary use of online non-downloadable software for remote scientific testing services of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; Providing temporary use of online non-downloadable software for remote biopharmaceutical research design and scientific testing services; Providing temporary use of online non-downloadable software for remote product safety and quality assurance testing services for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; Providing temporary use of online non-downloadable software for remote toxicological safety and quality assurance testing services for pharmaceuticals, chemicals, and consumer products; software as a service (SAAS) services featuring software for developing, executing, monitoring, and managing enterprise resource planning, experimental logistics, manufacturing execution systems, and connected factories; software as a service (SAAS) services featuring software for running computer simulations of laboratory experiments, for running computer simulations of biological and chemical phenomena and systems, for optimizing laboratory experiment parameters with computational methods, and for comparison of computer simulations against empirically observed laboratory experiment results; software as a service (SAAS) services featuring software for providing regulatory compliance documentation following experiments, for performing regulatory agencies audits following experiments, and for performing internal audits following experiments; software as a service (SAAS) services featuring software for processing of un-structured, semi-structured, and structured information relating to laboratory experiments and computer simulations of laboratory experiments and biological and chemical phenomena and systems
17.
System and method for management, execution, and analysis of laboratory experiments
The disclosure provides systems and methods for conducting and managing integrated laboratory experiments. The system includes a variety of laboratory instruments that are connected to conduct a large number of different types of experiments, and an interface for a user to design experiments and adjust parameters for the experiments. Given the integration, the system can further take data from related samples and instruments for determining or adjusting certain experimental parameters for optimized experimental efficiency and results.
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
18.
Laboratory experiment data exploration and visualization
The disclosure provides systems and methods for data analysis of experimental data. The analysis can include reference data that are not directly generated from the present experiment, which reference data may be values of the experimental parameters that were either provided by a user, computed by the system with input from a user, or computed by the system without using any input from a user. Another example of such reference data may be information about the instrument, such as the calibration method of the instrument.
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
42 - Scientific, technological and industrial services, research and design
Goods & Services
Software as a service featuring software for designing laboratory experiments, for running laboratory experiments, and for reviewing laboratory experiment controls, equipment, and environmental data ; software as a service featuring software for reviewing laboratory experiment results; software as a service featuring software for research and development of chemicals, pharmaceuticals, biologics, and vaccines; software as a service featuring software for scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; software as a service featuring software for biopharmaceutical research design and scientific testing services; software as a service featuring software for product safety testing for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; software as a service featuring software for toxicological safety testing services for pharmaceuticals, chemicals, and consumer products; software as a service for developing quality control and custom assays; software as a service for remotely deploying quality control and custom assays; software as a service for remotely managing the performance of quality control and custom assays; software as a service featuring software for running computer simulations of laboratory experiments, for running computer simulations of biological and chemical phenomena and systems, for optimizing laboratory experiment parameters with computational methods, and for comparison of computer simulations against empirically observed laboratory experiment results; and software as a service for providing regulatory compliance documentation following experiments, for performing regulatory agencies audits following experiments, and for performing internal audits following experiments
20.
SYSTEM AND METHOD FOR MANAGEMENT, EXECUTION, AND ANALYSIS OF LABORATORY EXPERIMENTS
The disclosure provides systems and methods for conducting and managing integrated laboratory experiments. The system includes a variety of laboratory instruments that are connected to conduct a large number of different types of experiments, and an interface for a user to design experiments and adjust parameters for the experiments. Given the integration, the system can further take data from related samples and instruments for determining or adjusting certain experimental parameters for optimized experimental efficiency and results.
G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
G16C 20/00 - Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
21.
LABORATORY EXPERIMENT DATA EXPLORATION AND VISUALIZATION
The disclosure provides systems and methods for data analysis of experimental data. The analysis can include reference data that are not directly generated from the present experiment, which reference data may be values of the experimental parameters that were either provided by a user, computed by the system with input from a user, or computed by the system without using any input from a user. Another example of such reference data may be information about the instrument, such as the calibration method of the instrument.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
22.
SYSTEM AND METHOD FOR MANAGEMENT, EXECUTION, AND ANALYSIS OF LABORATORY EXPERIMENTS
The disclosure provides systems and methods for conducting and managing integrated laboratory experiments. The system includes a variety of laboratory instruments that are connected to conduct a large number of different types of experiments, and an interface for a user to design experiments and adjust parameters for the experiments. Given the integration, the system can further take data from related samples and instruments for determining or adjusting certain experimental parameters for optimized experimental efficiency and results.
The disclosure provides systems and methods for data analysis of experimental data. The analysis can include reference data that are not directly generated from the present experiment, which reference data may be values of the experimental parameters that were either provided by a user, computed by the system with input from a user, or computed by the system without using any input from a user. Another example of such reference data may be information about the instrument, such as the calibration method of the instrument.
A fabrication process for producing, annealing, and conjugating nucleic acid molecules is implemented, under the direction of one or more computer programs, on two or more instruments, for carrying out the process. The process can include: (a) synthesizing, on a solid support and in a plurality of reactions, at least one of a nucleic acid and a peptide nucleic acid, and cleaving the synthesized biomolecule product from the support, providing a sample of synthesized biomolecule product from each reaction of the plurality; (b) measuring, for each sample, the volume of the sample and/or the concentration of the product; (c) subjecting the product from each reaction to chromatography under conditions suitable for achieving single-base-resolution for the product, the conditions being a function of the volume and/or concentration measured in (b); and then (d) collecting and pooling, from the chromatography of (c) for each sample, peaks that correspond to the product.
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C40B 50/00 - Methods of creating libraries, e.g. combinatorial synthesis
C40B 60/14 - Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Provided are nucleic acid translators capable of carrying out logic operations with improved efficiency, maximized output and reduced off-target effects, in particular in a biological system. Methods of using these translators to transduce signal are also provided.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
G06N 3/00 - Computing arrangements based on biological models
G06N 3/12 - Computing arrangements based on biological models using genetic models
B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medical laboratory services (terms considered too vague by
the International Bureau - Rule 13(2)(b) of the Common
Regulations); scientific laboratory services; conducting
laboratory experiments on behalf of others; software as a
service featuring software for designing laboratory
experiments, for running laboratory experiments, for
reviewing laboratory experiment controls, equipment, and
environment data, and for reviewing laboratory experiment
results (terms considered too vague by the International
Bureau - Rule 13(2)(b) of the Common Regulations); custom
assay development (terms considered too vague by the
International Bureau - Rule 13(2)(b) of the Common
Regulations); research and development of chemicals,
pharmaceuticals, biologics, vaccines and medical devices;
scientific testing of chemicals, pharmaceuticals, biologics,
vaccines, and medical devices; biopharmaceutical research
design and scientific testing services; product safety
testing for pharmaceuticals, biopharmaceuticals, chemicals,
medical devices, vaccines, and biologics; toxicological
safety testing services for pharmaceuticals, chemicals, and
consumer products.
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Medical laboratory services; scientific laboratory services; conducting laboratory experiments on behalf of others; software as a service featuring software for designing laboratory experiments, for running laboratory experiments, for reviewing laboratory experiment controls, equipment, and environment data, and for reviewing laboratory experiment results; custom assay development; research and development of chemicals, pharmaceuticals, biologics, vaccines and medical devices; scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; biopharmaceutical research design and scientific testing services; product safety testing for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; toxicological safety testing services for pharmaceuticals, chemicals, and consumer products
Conjugated molecules are prepared that comprise a predetermined number of oligo conjugation components. The conjugated molecules also may comprise one or more detectable labels. Preparation of these molecules can be implemented according to an asymmetric or a symmetric conjugation strategy.
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
42 - Scientific, technological and industrial services, research and design
Goods & Services
Medical laboratory services; scientific laboratory services; conducting laboratory experiments on behalf of others; software as a service featuring software for designing laboratory experiments, for running laboratory experiments, for reviewing laboratory experiment controls, equipment, and environment data, and for reviewing laboratory experiment results; custom assay development; research and development of chemicals, pharmaceuticals, biologics, vaccines and medical devices; scientific testing of chemicals, pharmaceuticals, biologics, vaccines, and medical devices; biopharmaceutical research design and scientific testing services; product safety testing for pharmaceuticals, biopharmaceuticals, chemicals, medical devices, vaccines, and biologics; toxicological safety testing services for pharmaceuticals, chemicals, and consumer products
Provided are nucleic acid translators capable of carrying out logic operations with improved efficiency, maximized output and reduced off-target effects, in particular in a biological system. Methods of using these translators to transduce signal are also provided.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
G06N 3/00 - Computing arrangements based on biological models
G06N 3/12 - Computing arrangements based on biological models using genetic models
B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
31.
System and method for propagating information using modified nucleic acids
Improvement is effected for a nucleic acid-based molecular computing system that is comprised of (i) a nucleic acid structure, (ii) at least one polynucleotide displacement molecule that can bind with the nucleic acid structure under hybridizing conditions, and (iii) a clashing polynucleotide molecule that competes with the polynucleotide displacement molecule for binding the nucleic acid structure under the hybridizing conditions. The method for such improvement entails incorporating chemical modification that inhibits the binding of the clashing molecule and the nucleic acid structure or facilitating the binding of the displacement molecule and the nucleic structure.
G06N 3/00 - Computing arrangements based on biological models
G06F 19/22 - for sequence comparison involving nucleotides or amino acids, e.g. homology search, motif or Single-Nucleotide Polymorphism [SNP] discovery or sequence alignment
G06N 3/12 - Computing arrangements based on biological models using genetic models
B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
An approach to designing a polynucleotide probe to hybridize selectively to a target polynucleotide sequence involves calculating the final concentration of the intended binding product between a candidate probe and the target sequence. The calculation takes into consideration the binding reaction between the candidate probe and the target fragment on the target sequence, as well as various other binding reactions, involving either the probe or the target fragment, that interfere with the intended binding reaction. In contrast to the conventional technology, which attempts to determine the entire structure of the target polynucleotide, this approach only needs to determine the binding dynamics that impact on the intended probe-target fragment binding. The approach does not require determination of the structure of the involved sequences.
A method is provided for improving a nucleic acid-based molecular computing system comprised of (i) a nucleic acid structure, (ii) at least one polynucleotide displacement molecule that can bind with the nucleic acid structure under hybridizing conditions, and (iii) a clashing polynucleotide molecule that competes with the polynucleotide displacement molecule for binding the nucleic acid structure under the hybridizing conditions The method entails incorporation of chemical modification that inhibits the binding of the clashing molecule and the nucleic acid structure or facilitates the binding of the displacement molecule and the nucleic structure.
