Abstract

The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

IPC Classes  ?

• C07D 211/12 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
• C07D 263/52 - Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
• C09B 15/00 - Acridine dyes
• C09B 57/00 - Other synthetic dyes of known constitution

Abstract

Disclosed herein are various systems, apparatuses, software, and methods relating to data diode-TCP proxy with a User Datagram Protocol (UDP) across a wide area network (WAN) comprising providing a WAN data diode using a uni-directional semantics protocol, providing a set of data diode proxies in either end of a point-to-point WAN link, providing a symmetric key encryption semantics to extend the WAN data diode securely across a WAN that is specified, wherein the symmetric key encryption semantics are implemented through the set of data diode proxies on either end of the point-to-point WAN link, employing a unidirectional protocol in communication transmitted using the WAN, and, with data diode proxies, terminating one or more data channels on either end of the point-to-point WAN link or transporting a requisite information across the WAN over the uni-directional protocol.

IPC Classes  ?

• H04L 29/06 - Communication control; Communication processing characterised by a protocol
• H04L 69/164 - Adaptation or special uses of UDP protocol
• H04L 9/40 - Network security protocols
• H04L 69/168 - Implementation or adaptation of Internet protocol [IP], of transmission control protocol [TCP] or of user datagram protocol [UDP] specially adapted for link layer protocols, e.g. asynchronous transfer mode [ATM], synchronous optical network [SONET] or point-to-point protocol [PPP]
• H04L 12/46 - Interconnection of networks
• H04L 67/563 - Data redirection of data network streams

Abstract

In one aspect, a computerized method for implementing edge web services includes the step of providing an edge device. The edge device is provided for free to a customer. The method includes the step of monitoring a usage on the edge device by the customer. The method includes the step of charging an edge-device entity based on the usage of the edge device and an application in the edge device. An orchestrator communicates the edge device usage statistics to an enterprise system that provided the edge device to the customer.

IPC Classes  ?

• H04L 41/5067 - Customer-centric QoS measurements
• H04L 67/00 - Network arrangements or protocols for supporting network services or applications
• G06F 11/30 - Monitoring

Goods & Services

Fluorescent dye for scientific or research use

Goods & Services

Fluorescent dye for scientific or research use

Goods & Services

Reagents for scientific and research use; Reagents for use in scientific apparatus for chemical or biological analysis; Chemical reagents, other than for medical or veterinary purposes; Diagnostic reagents and preparations, except for medical or veterinary use; Diagnostic reagents for scientific or research use; Nucleic acid sequences and chemical reagents for other than medical and veterinary purposes

Goods & Services

Fluorescent dye for scientific or research use; Reagents for scientific and research use; Chemical solutions and preparations consisting of pre-mixed reactants and reagents for scientific and research use in connection with amplification, analysis or labeling of nucleic acid

Goods & Services

Reagents for scientific and research use; Chemical solutions and preparations consisting of pre-mixed reactants and reagents for scientific and research use in connection with amplification, analysis or labeling of nucleic acid; Fluorescent dye for scientific or research use

Goods & Services

Nucleic acid for laboratory use; Reagents for scientific and research use; Chemical solutions and preparations consisting of pre-mixed reactants and reagents for scientific and research use in connection with amplification, analysis or labeling of nucleic acid

Goods & Services

Reagents for scientific and research use; Chemical solutions and preparations consisting of pre-mixed reactants and reagents for scientific and research use in connection with amplification, analysis or labeling of nucleic acid; Nucleic acid for laboratory use

Goods & Services

Reagents for scientific and research use; Enzyme substrates

Goods & Services

Nucleic acid for laboratory use; Nucleic acid isolation and purification kit consisting primarily of reagents and magnetic beads for scientific research purposes; Reagents for scientific or medical research use

Goods & Services

Nucleic acid for laboratory use; Nucleic acid isolation and purification kit consisting primarily of reagents and magnetic beads for scientific research purposes; Reagents for scientific and research use

Goods & Services

Reagents for scientific and research use; Chemical solutions and preparations consisting of pre-mixed reactants and reagents for scientific and research use in connection with amplification, analysis or labeling of nucleic acid; Fluorescent dye for scientific or research use

Goods & Services

Reagents for scientific and research use; Chemical solutions and preparations consisting of pre-mixed reactants and reagents for scientific and research use in connection with amplification, analysis or labeling of nucleic acid; Fluorescent dye for scientific or research use

Goods & Services

Cells for scientific and research use; Reagents for scientific and research use

Goods & Services

Chemical solutions and preparations consisting of pre-mixed reactants and reagents for scientific and research use in connection with amplification, analysis or labeling of nucleic acid; Nucleic acid for laboratory use

Abstract

In some aspects, the disclosure provides compounds comprising nucleic acid modifying moieties, such as nucleic acid binding dyes comprising activatable groups. In some aspects, the disclosure provides nucleic acid probes comprising compounds of the disclosure, and methods of making the same. In some aspects, the disclosure provides methods of using compounds of the disclosure, such as methods of labeling and/or detecting non- viable organisms or non- viable cells, and methods of detecting contamination or infection.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

The invention provides compounds, including fluorescent nucleic acid dyes, and methods for use including nucleic acid detection, nucleic acid amplification reactions, and high-resolution melt curve analysis. Further provided are kits, instruments and systems comprising compounds of the invention or adapted for use with compounds of the invention or other nucleic acid dyes.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.

IPC Classes  ?

• C09B 1/516 - N-acylated derivatives
• C09B 1/00 - Dyes with an anthracene nucleus not condensed with any other ring

Abstract

The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

IPC Classes  ?

• C07D 311/00 - Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
• C07D 335/00 - Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom

Abstract

The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

IPC Classes  ?

• C07D 405/00 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom

Abstract

The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence

Abstract

Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.

IPC Classes  ?

• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions

Goods & Services

reagents, fluorescent reagents and luminescent reagents for use in assays or bioassays in the field of life science research

Abstract

Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.

IPC Classes  ?

• C07D 213/02 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
• C07D 401/02 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings

Abstract

Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C07D 213/02 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
• C07D 401/02 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings