Disclosed is a beauty treatment device that kills adipocytes by locally sucking in skin to be treated and sequentially applying a high-frequency current and a high-voltage pulse. The beauty treatment device according to the present invention comprises: a main body unit; and a suction treatment unit coupled to the main body unit and having a treatment space for applying electrical stimulation by sucking in the skin of a user, wherein the suction treatment unit comprises: a suction nozzle made of a resin material, which partitions the treatment space; and a pair of electrodes disposed inside the suction nozzle so as to face each other at a distance, and the pair of electrodes have a metal conductive layer formed by plating the surface of a resin material electrode core with a conductive metal.
Provided is a method for manufacturing yarn for a cell culture scaffold. The method includes: (1) preparing a ply yarn by twisting a plurality of fiber strands; and (2) partially untwisting at least one part of the ply yarn in the longitudinal direction in a direction opposite to a direction in which the fiber strands are twisted to implement a space which is formed by spacing apart of the adjacent fiber strands within the untwisted part. The fiber strand is spun yarn, filament yarn or slitting yarn.
D02G 1/02 - Producing crimped or curled fibres, filaments, yarns or threads, giving them latent characteristics by twisting, fixing the twist and backtwisting, i.e . by imparting false twist
D02G 3/44 - Yarns or threads characterised by the purpose for which they are designed
3.
CELL CULTURE SCAFFOLD, AND PREPARATION METHOD THEREOF
Provided is a cell culture scaffold including a scaffold; and a cell culture coating layer which covers at least a portion of the surface of the scaffold and comprises a fusion polypeptide including a peptide for cell culture and a peptide for adhesion. Accordingly, the cell culture scaffold can achieve high cell culture efficiency due to having excellent adhesiveness with respect to various cells and being capable of stably proliferating adhered cells, can be stored at room temperature for several years, thus having excellent storage stability, prevents imaging interference, which can occur during cell observation or fluorescence analysis on the cell culture scaffold, due to the smooth surface of the cell culture coating layer formed by the fusion polypeptide, thus being applicable to various cell cultures, and, in particular, can express an excellent effect on the proliferation and differentiation of neural stem cells or neural precursor cells.
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
Provided is a method for the mass production of stem cell-derived extracellular vesicles. The stem cell-derived extracellular vesicles according to one embodiment of the present invention can be produced by (1) a step for producing a culture containing the extracellular vesicles by culturing stem cells through a medium-recirculating bioreactor, and (2) a step for isolating and obtaining the extracellular vesicles from the culture. According to the above, stem cells cultured through the medium-recirculating bioreactor are cultured in a state in which the expression of related genes is enhanced so that extracellular vesicle production and secretion can occur vigorously, thus making it possible to produce the extracellular vesicles with high yield. At the same time, the obtained extracellular vesicles have excellent effects, such as anti-inflammation, healing of damaged tissues, and promotion of cell proliferation, on the self-renewal and immunomodulation inherent to stem cells, compared to extracellular vesicles derived from stem cells cultured and obtained by other methods, and thus can be widely applied as a pharmacological component substituting for a cell therapeutic agent.
Provided is a cell culture substrate for promoting osteocyte differentiation. In one embodiment of the present invention, the cell culture substrate includes a fiber web and an osteoblast differentiation-promoting layer that is applied to at least a portion of the surface of the fiber web and which comprises a fusion polypeptide including a peptide for osteocyte differentiation and a peptide for attachment. According to the cell culture substrate, the adhesion of osteoblasts can be improved to minimize or prevent the detachment of attached cells in spite of shaking, such as the flow of cell culture medium, which may take place during cell culture and differentiation. In addition, the cell culture substrate improves the proliferation of osteoblasts and achieves high differentiation efficiency into osteocytes, thus finding wide applications in bone tissue reconstruction and regeneration.
C12M 1/00 - Apparatus for enzymology or microbiology
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
6.
COMPOSITE MEMBRANE FOR WESTERN BLOTTING CONTAINING A PVDF NANOFIBER WEB AND MANUFACTURING METHOD THEREOF
Provided is a composite membrane for western blot, in which the composite membrane is prepared by combining nanofiber webs with nonwoven fabrics, and a basis weight of the nanofibers is in a range of 1 gsm to 50 gsm on the nonwoven fabrics, and an average pore size is in a range of 0.1 μm to 1.0 μm. The composite membrane for western blot including nanofibers has advantages such as saving of a production cost, and an excellent response characteristic due to a capillary phenomenon of a double structure, to thereby easily detect even a small amount of a particular substance present in a protein.
D01D 5/00 - Formation of filaments, threads, or the like
D04H 1/44 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling
D04H 1/555 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving by ultrasonic heating
G01N 33/544 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
A mask is provided. The mask according to an embodiment of the present invention comprises: an outer skin which forms an externally exposed surface when the mask is worn; an inner skin fixed to one surface of the outer skin so that an accommodation portion having at least one side open is formed between the outer skin and one surface of the inner skin facing the outer skin while the inner skin is in close contact with a user's face part when the mask is worn; a filter medium accommodated in the accommodation portion; and wearing portions provided on both sides of the outer skin to be respectively worn on the user's ears.
D03D 15/292 - Conjugate, i.e. bi- or multicomponent, fibres or filaments
D04H 3/16 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating with bonds between thermoplastic yarns or filaments produced by welding with bonds between thermoplastic filaments produced in association with filament formation, e.g. immediately following extrusion
D04H 1/56 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving in association with fibre formation, e.g. immediately following extrusion of staple fibres
B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
A62B 18/08 - Component parts for gas-masks or gas-helmets, e.g. windows, straps, speech transmitters, signal-devices
8.
CELL CULTURE SUBSTRATE AND MANUFACTURING METHOD THEREOF
A cell culture substrate including a substrate provided with a non-porous surface and a cell culture coating layer that covers at least a portion of the non-porous surface, wherein the cell culture coating layer is implemented such that particles formed of fusion proteins for culturing cells are aggregated to form at least a portion of the surface, the fusion proteins comprising functional peptides bound to mussel adhesive proteins. In particular, despite containing compounds such as proteins that are beneficial to culturing cells, the cell culture substrate can be stored at room temperature for a long period of time over several years, exhibiting excellent storage stability, while activities of such compounds that are beneficial to culturing of the cells remain unchanged or only suffer minimal degradation so that the cells can be cultured at an initially-designed level.
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
9.
METHOD FOR PRODUCING FLUORESCENT MAGNETIC NANOPARTICLES, AND FLUORESCENT MAGNETIC NANOPARTICLES PRODUCED THROUGH SAME
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) (Republic of Korea)
Inventor
Kim, Sung-Il
Lee, Jaebeom
Hwang, Dajeong
Nguyen, Huu-Quang
Abstract
A method for producing fluorescent magnetic nanoparticles is provided. Fluorescent magnetic nanoparticles, according to one embodiment of the present invention, are implemented comprising the steps of: (1) preparing a magnetic body as a core part; and (2) forming a first silica layer by treating a first silica forming component to surround the core part, and then forming a fluorescent shell part containing a silica layer and a fluorescent material doped in the silica layer by treating, on the first silica layer, a fluorescent material, which is a lanthanide complex, and a second silica-forming component. According to this, the produced fluorescent magnetic nanoparticles are very uniform and prevent agglomeration, can express high PL intensity and quantum yield, and have excellent durability. In addition, since the fluorescent magnetic nanoparticles can improve flowability, the range of applications thereof can be further expanded in various diagnostic and detection fields, and can be widely applied to various fields of diagnosis and detection, such as in a highly sensitive in vitro diagnostic kit and a fluorescent nanoprobe for biomolecular imaging diagnosis which is useful for detecting a target substance.
H01F 1/01 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of inorganic materials
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
B82Y 40/00 - Manufacture or treatment of nanostructures
10.
ANTI-VIRAL COATING COMPOSITION, AND METHOD FOR FIXING ANTI-VIRAL FUSION PROTEIN TO SURFACES
An antiviral coating composition is provided. An antiviral coating composition according to one embodiment of the present invention is implemented by including an antiviral component comprising an antiviral fusion protein in which an antiviral motif is bound to an adhesive protein. According to the present invention, the composition has excellent processability enabling easy provision on various surfaces of various products, has adhesion sustainability enabling an adhesive state to be maintained for a long period of time after being adhered to a surface, and has activity sustainability enabling antiviral activity to be maintained for a long period of time without a loss in activity according to external conditions during preparation, storage and use.
Provided is a cell culture scaffold. The cell culture scaffold according to an embodiment of the present invention comprises: a scaffold; and a cell culture coating layer which covers at least a portion of the surface of the scaffold and comprises a fusion polypeptide including a peptide for cell culture and a peptide for adhesion. Accordingly, the cell culture scaffold according to the present invention can achieve high cell culture efficiency due to having excellent adhesiveness with respect to various cells and being capable of stably proliferating adhered cells, can be stored at room temperature for several years, thus having excellent storage stability, prevents imaging interference, which can occur during cell observation or fluorescence analysis on the cell culture scaffold, due to the smooth surface of the cell culture coating layer formed by the fusion polypeptide, thus being applicable to various cell cultures, and, in particular, can have an excellent effect on the proliferation and differentiation of neural stem cells or neural precursor cells.
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
The present invention relates to a lifting band comprising: a band member provided in the form of a plate having elasticity and resilience and having a predetermined area; at least one light source part disposed on one surface of the band member and including a plurality of LEDs that, when power is applied, emit light of a predetermined wavelength band so as to improve the skin; and a cover member which is fixed to one surface of the band member so as to cover the at least one light source part.
A mask is provided. The mask according to one embodiment of the present invention comprises: a first fabric forming an externally exposed surface; a second fabric disposed on one surface of the first fabric to be in close contact with a part of the wearer's face and including a first fiber including a silver wire; and ear bands provided on the opposite ends of the first fabric. Accordingly, the mask including the silver wire can fundamentally prevent the, generation of bacteria by a user's saliva and re-inhalation of proliferated bacteria and has excellent antibacterial performance. In addition, the mask provided with a ply yarn including a silver wire and a general-purpose fiber has excellent washing durability and elasticity and can have the effect of maintaining antibacterial performance and washing durability even when the silver wire included in the mask is broken.
A cell culture substrate including a fibrous web in which fibers are integrated, and a cell culture coating layer comprising a coating film connecting at least some fibers from among fibers positioned on one surface of the fibrous web, wherein the cell culture coating layer is realized through a fusion protein for cell culture in which a functional peptide is bound to a mussel adhesive protein. Thus, the substrate can be stored at room temperature for a long period of time, i.e., several years, despite containing protein-like substances that aid in cell culture, and thus exhibits very high storage stability. At the same time, the activity of substances that aid in cell culture is maintained at the same level or is reduced only minimally, thus enabling cell culture at an initially designed level.
2; and a functional coating layer which is coated on the support fibers exposed on at least one surface of the fiber web, and has a function of promoting one or more of the adhesion, movement, proliferation, and differentiation of cells. Accordingly, cell adhesion is improved due to the large specific surface area and the surface morphology suitable for cells, and the adhered cells are stably supported. Moreover, the cells can be cultured at high density at a high culture efficiency, and can be cultured and recovered without agglomeration caused by forming a thin film.
A heating patch for skin care including a substrate unit; an application electrode unit formed on the substrate unit in a predetermined pattern, and which includes a first electrode and a second electrode to which power supplied from the outside is applied; a heating unit including first and second heating electrodes, which respectively extend a predetermined length from the first and second electrodes so as to face each other at a certain length without being electrically connected, and a plurality of conductive heating materials formed to have predetermined areas in an overlapping part in which the first and second heating electrodes face each other and generate heat while allowing the first and second heating electrodes to communicate with each other during application of power; and a pair of cover members arranged on both surfaces of the substrate unit to prevent external exposure of the applied electrode unit and heating unit.
Provided is a dry cosmetic sheet including: a dry support formed of a mesh, the mesh being made of a woven silver yarn; and a dry membrane laminated on the support, the dry membrane being capable of being attached to a users skin, and the dry membrane being formed of a fiber web, the fiber web being formed of accumulated electrospun fibers, each of the electrospun fibers being formed of a single homogeneous mixture containing a water-soluble polymer, a water-insoluble polymer, and a functional material for skin care in a dry state, the functional material being capable of releasing from the fiber by dissolution of the water-soluble polymer when the dry cosmetic sheet is moisturized. Each of the electrospun fibers has a homogenous distribution of the water-soluble polymer, the water-insoluble polymer, and the functional material.
B32B 7/06 - Interconnection of layers permitting easy separation
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
19.
LED patch for skin care apparatus and skin care apparatus including the same
An LED patch for a skin care apparatus is provided. An LED patch for a skin care apparatus according to an exemplary example of the present invention comprises: a substrate part; a circuit pattern part formed in at least two layers on the substrate part; a light source part including one or more LEDs mounted on one surface of the substrate part; and a cover part configured to cover at least one surface of the substrate part.
A mask is provided. The mask according to an embodiment of the present invention comprises: an outer skin which forms an externally exposed surface when the mask is worn; an inner skin fixed to one surface of the outer skin so that an accommodation portion having at least one side open is formed between the outer skin and one surface of the inner skin facing the outer skin while the inner skin is in close contact with a user's face part when the mask is worn; a filter medium accommodated in the accommodation portion; and wearing portions provided on both sides of the outer skin to be respectively worn on the user's ears.
An ultraviolet protection patch is provided. An ultraviolet protection patch, according to one embodiment of the present invention, is implemented by comprising: an ultraviolet protection layer including a support component and an ultraviolet protection agent; and a first shape-retaining layer which is a fiber web provided on one surface of the ultraviolet protection layer. According to this, as the ultraviolet protection patch comprises the ultraviolet protection layer and the shape-retaining layer which have predetermined properties, an ultraviolet protection material does not directly contact the skin, and thus skin trouble, irritation, and white cast do not occur, and as the patch is excellent in elasticity, the patch has excellent stiffness without inhibiting movement of a site to which the patch is adhered or peeling off even by physical stimuli, and the ultraviolet protection layer and the shape-retaining layer have a predetermined basis weight relationship, thereby having excellent transparency, and thus, there is an effect of not reducing visibility of the site to which the patch is adhered when the patch is adhered to the skin.
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (Republic of Korea)
AMOLIFESCIENCE CO., LTD. (Republic of Korea)
Inventor
Kwon, Sang Mo
Lee, Na Kyung
Goo, Hui Gwan
Seo, Dong Sik
Kim, Hyeong Taek
Abstract
The present invention relates to a fusion protein for cell culture, and more particularly to a fusion protein containing an extracellular matrix motif and a mussel adhesive protein. It was confirmed that the fusion protein for cell culture according to the present invention not only increases the biological activity of cultured cells, i.e., cell adhesion ability, cell migration ability, ability to inhibit cellular senescence, and colony formation ability, but also significantly improves cell yield. Therefore, the fusion protein for cell culture according to the present invention may be utilized in various ways in the fields of cell culture and cell therapeutic agents.
C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
The present invention relates to a lifting band comprising: a band member provided in the form of a plate having elasticity and resilience and having a predetermined area; at least one light source unit disposed on one surface of the band member and including a plurality of LEDs that, when power is applied, emit light of a predetermined wavelength band so as to improve the skin; and a cover member which is fixed to one surface of the band member so as to cover the at least one light source unit.
An anti-viral coating composition is provided. An anti-viral coating composition according to one embodiment of the present invention comprises an anti-viral component comprising an anti-viral fusion protein in which an anti-viral motif is bound to an adhesion protein. According to the present invention, the composition has excellent processability enabling easy provision on various surfaces of various products, has adhesion sustainability enabling an adhesive state to be maintained for a long period of time after being adhered to a surface, and has activity sustainability enabling anti-viral activity to be maintained for a long period of time without having loss in activity according to external conditions during preparation, storage and use.
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
A mask is provided. The mask according to one embodiment of the present invention comprises: a first fabric forming an externally exposed surface; a second fabric disposed on one surface of the first fabric to be in close contact with a part of the wearer's face and including a first fiber including a silver wire; and ear bands provided on the opposite ends of the first fabric. Accordingly, the mask including the silver wire can fundamentally prevent the generation of bacteria by a user's saliva and re-inhalation of proliferated bacteria and has excellent antibacterial performance. In addition, the mask provided with a ply yarn including a silver wire and a general-purpose fiber has excellent washing durability and elasticity and can have the effect of maintaining antibacterial performance and washing durability even when the silver wire included in the mask is broken.
A patch-type thermometer is provided. A patch-type thermometer according to an exemplary embodiment of the present invention comprises: a flexible circuit board which has an antenna pattern formed on at least one surface thereof and at least one driving chip mounted thereon; a temperature sensor mounted on the flexible circuit board so as to measure a user's body temperature; a heat transfer member electrically connected to the temperature sensor by means of a via hole and mounted on a surface opposite to a surface of the flexible circuit board on which the temperature sensor is mounted, so that the heat transfer member can come into direct contact with a user's skin; and a protective member surrounding the flexible circuit board so as to prevent the antenna pattern, the driving chip, and the temperature sensor from being exposed to the outside.
A cell culture substrate is provided. According to one embodiment of the present invention, the cell culture substrate includes a substrate provided with a non-porous surface and a cell culture coating layer that covers at least a portion of the non-porous surface, wherein the cell culture coating layer is implemented such that particles formed of fusion proteins for culturing cells are aggregated to form at least a portion of the surface, the fusion proteins comprising functional peptides bound to mussel adhesive proteins. In particular, despite containing compounds such as proteins that are beneficial to culturing cells, the cell culture substrate can be stored at room temperature for a long period of time over several years, exhibiting excellent storage stability, while activities of such compounds that are beneficial to culturing of the cells remain unchanged or only suffer minimal degradation so that the cells can be cultured at an initially-designed level. Further, the cell culture substrate has an excellent cell adhesion capability that allows reliable proliferation of the cells attached thereto, and thus can achieve a high cell culture efficiency. Accordingly, the cell culture substrate can be widely utilized for culturing various cells including stem cells.
A cell culture substrate is provided. A cell culture substrate according to an embodiment of the present invention comprises: a fibrous web in which fibers are integrated; and a cell culture coating layer comprising a coating film connecting at least some fibers from among fibers positioned on one surface of the fibrous web, wherein the cell culture coating layer is realized through a fusion protein for cell culture in which a functional peptide is bound to a mussel adhesive protein. Thus, the substrate can be stored at room temperature for a long period of time, i.e., several years, despite containing protein-like substances that aid in cell culture, and thus exhibits very high storage stability. At the same time, the activity of substances that aid in cell culture is maintained at the same level or is reduced only minimally, thus enabling cell culture at an initially designed level. In addition, the cell culture substrate has excellent cell adhesion and can stably proliferate adhered cells, and thus can achieve high cell culture efficiency, and accordingly, can be widely applied to the culture of various cells such as stem cells.
A cell culture vessel including an accommodating part which is an inner space accommodating a cell culture support therein, a fixing member configured to fix the cell culture support to a lower surface of the accommodating part, wherein the fixing member includes a first adhesive layer attached to the lower surface of the accommodating part, a second adhesive layer attached to a lower surface of the cell culture support, and a support film interposed between the first adhesive layer and the second adhesive layer and configured to perform a support function, and an adhesive force between the second adhesive layer and the cell culture support is higher than an adhesive force between the first adhesive layer and the lower surface of the accommodating part.
Provided is a cell culture sheet. A cell culture sheet according to an embodiment of the present invention includes: a fiber web which has a 3-dimensional network structure formed through the accumulation of support fibers having an average diameter of at most 1.5 ㎛, and has a basis weight of 1-15 g/㎡; and a functional coating layer which is coated on the support fibers exposed on at least one surface of the fiber web, and has a function of promoting one or more of the adhesion, movement, proliferation, and differentiation of cells. Accordingly, cell adhesion is improved due to the large specific surface area and the surface morphology suitable for cells, and the adhered cells are stably supported. Moreover, the cells can be cultured at high density at a high culture efficiency, and can be cultured and recovered without agglomeration caused by forming a thin film. Also, the cells obtained are smaller than cells cultured through a conventional culture, and thus the cell culture sheet is very advantageous for culturing and proliferating younger and healthier cells without changing the character thereof. In addition, the cell culture sheet has an excellent effect on the differentiation of stem cells into specific target cells, as well as the proliferation thereof.
Provided is a cosmetic patch. A cosmetic patch according to one embodiment of the present invention is implemented by comprising: a skin attachment layer including a fibrous web and a moisturizing composition filled in the pores of the fibrous web; a first cover layer disposed on one side of the skin attachment layer; and a second cover layer disposed on the other side of the skin attachment layer. Accordingly, the cosmetic patch can prevent or delay the volatilization of effective ingredients to be provided to the skin, while having high content of the effective ingredients. In addition, even though the cosmetic patch is implemented in a very thin thickness, the cosmetic patch can have sufficient content of the effective ingredients, and since excessive content of the effective ingredients is not provided, it is possible to prevent discomfort during use or contamination due to spillage of the effective ingredients on areas other than the skin to be treated. Furthermore, since the cosmetic patch has excellent clinginess and adhesiveness to the skin without a separate adhesive layer or bonding layer, it is possible to prevent skin problems due to ingredients forming the separate adhesive layer or bonding layer, or a problem of the ingredients partially being dissolved and remaining on the skin.
A patch-type thermometer fixing adhesive band is provided. A patch-type thermometer fixing adhesive band according to an exemplary embodiment of the present invention is for fixing, to skin, a patch-type thermometer including a body temperature detection member for measuring the body temperature of a user, and comprises: a body which includes a first surface that has a first adhesive surface on which a first adhesive layer is formed and a noncontact surface on which the first adhesive layer is not formed, and a second surface that is the opposite surface of the first surface and is provided with a second adhesive surface on which a second adhesive layer is formed; a passing part which is formed through the body to allow a partial length of the patch-type thermometer to pass therethrough; a first release sheet which is attached to the first adhesive surface by using the first adhesive layer as a medium; and a second release sheet which is attached to the second adhesive surface by using the second adhesive layer as a medium.
A heating patch for skin care is provided. A heating patch for skin care, according to an exemplary embodiment of the present invention, comprises: a substrate unit; an application electrode unit which is formed on the substrate unit in a predetermined pattern, and which includes a first electrode and a second electrode to which power supplied from the outside is applied; a heating unit including a first heating electrode and a second heating electrode, which respectively extend a predetermined length from the first electrode and the second electrode so as to face each other at a certain length without being electrically connected, and a plurality of conductive heating materials, which are formed to have predetermined areas in an overlapping part in which the first heating electrode and the second heating electrode face each other and generate heat while allowing the first heating electrode and the second heating electrode to communicate with each other during the application of power; and a pair of cover members arranged on both surfaces of the substrate unit in order to prevent the external exposure of the applied electrode unit and the heating unit.
An LED patch for a skin care apparatus is provided. An LED patch for a skin care apparatus according to an exemplary example of the present invention comprises: a substrate part; circuit pattern parts formed in at least two layers on the substrate part; a light source part comprising at least one LED mounted on one surface of the substrate part; and a cover part covering at least one surface of the substrate part.
KANGWON NATIONAL UNIVERSITY UNIVERSITY-INDUSTRY COOPERATION FOUNDATION (Republic of Korea)
Inventor
Ha, Kwon-Soo
Abstract
Disclosed is a composition and a method for the prevention or treatment of diabetic complications, which includes C-peptide bound to elastin-like polypeptide (ELP) and is thus capable of effectively preventing or treating diseases resulting from hyperglycemia, which is a major cause of diabetes, for example, diabetic retinopathy, and the like.
A scaffold for cell culture or tissue engineering is provided. The scaffold includes a fiber web having a three-dimensional network structure, which includes a biodegradable scaffold fiber. Therefore, a microenvironment suitable for migration, proliferation and differentiation of cells to be cultured is created, thereby improving a cell proliferation rate and cell viability. In addition, the scaffold may be easily removed from cells cultured therein without physical/chemical stimuli, and thus the cultured cells may be easily recovered, and is able to be grafted into the body while the cultured cells are included in the scaffold. Moreover, the cultured cells may be cultured to have a similar shape/structure to those of an actual animal body to make it more suitable to be applied in grafting into an in vitro experimental model or animal body.
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
D01D 5/00 - Formation of filaments, threads, or the like
D01F 6/12 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polymers of halogenated hydrocarbons from polymers of fluorinated hydrocarbons
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
37.
Method of manufacturing superparamagnetic nanocomposite and superparamagnetic nanocomposite manufactured using the same
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (Republic of Korea)
Inventor
Kim, Sung-Il
Choi, Min-Young
Lee, Myoung-Yeol
Lee, Jae-Beom
Tran, Van Tan
Kim, Jeong-Hyo
Oh, Sang-Jin
Abstract
The present invention relates to a method of manufacturing a superparamagnetic nanocomposite and a superparamagnetic nanocomposite manufactured using the same, and more particularly to a method of manufacturing a superparamagnetic nanocomposite suitable for use in magnetic separation for the detection of a target biomaterial and a superparamagnetic nanocomposite manufactured using the same. The method of manufacturing the superparamagnetic nanocomposite according to the present invention has a higher yield and a high rate without complicated processing than a conventional method of manufacturing a magnetic nanoparticle for magnetic separation and is capable of mass production of the superparamagnetic nanocomposite having excellent properties with uniform size and particle size distribution, high aqueous solution dispersibility and high magnetization and being capable of maintaining superparamagnetism.
H01F 1/34 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites
An ultraviolet protection patch is provided. An ultraviolet protection patch, according to one embodiment of the present invention, is implemented by comprising: an ultraviolet protection layer including a support component and an ultraviolet protection agent; and a first shape-retaining layer which is a fiber web provided on one surface of the ultraviolet protection layer. According to this, as the ultraviolet protection patch comprises the ultraviolet protection layer and the shape-retaining layer which have predetermined properties, an ultraviolet protection material does not directly contact the skin, and thus skin trouble, irritation, and white cast do not occur, and as the patch is excellent in elasticity, the patch has excellent stiffness without inhibiting movement of a site to which the patch is adhered or peeling off even by physical stimuli, and the ultraviolet protection layer and the shape-retaining layer have a predetermined basis weight relationship, thereby having excellent transparency, and thus, there is an effect of not reducing visibility of the site to which the patch is adhered when the patch is adhered to the skin.
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations
A45D 44/00 - Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
A45D 44/22 - Face shaping devices, e.g. chin strapsWrinkle removers, e.g. stretching the skin
Provided are a micro-needle patch and a manufacturing method thereof. The micro-needle patch includes: a support on one surface of which grooves are formed; a gel membrane for delivery of a transmitter to be transferred in which the grooves are filled with a mixture of the transmitter with a biodradable resin, the mixture being in a gel phase; a plurality of micro-needles projected on the other surface of the support and for penetrating the skin; a first protective film that covers the gel membrane and is adhered on the support; and a second protective film that covers the plurality of micro-needles and is adhered on the other surface, wherein passages are formed by being penetrated from the support to each of the plurality of micro-needles or formed by penetrating the support between the plurality of micro-needles, so that the transmitter of the gel membrane is transferred to the skin.
A dermal adhesive patch is provided. The dermal adhesive patch is adhered to skin through an ampoule containing a mixing ingredient, a drying ingredient, a viscosity control ingredient, and a moisturizing ingredient. The dermal adhesive patch includes: a support body; and a membrane layer formed as a nanofiber web having pores to block moisture and to allow air to pass through the membrane layer, and detachably laminated on one surface of the support body.
Provided is a heating patch. The heating patch includes: a flexible plate-shaped base substrate; an electrode portion including a pair of lead electrodes formed on at least one surface of the base substrate along a longitudinal direction to be spaced apart along a width direction of the base substrate, and a pair of branch electrodes extending from the lead electrodes along the width direction of the base substrate to be not electrically connected to each other and to be overlapped with each other; a heating portion including a conductive heating material disposed in an overlapped part between the branch electrodes which have a predetermined area and face each other to generate heat while conducting the pair of branch electrodes to each other; and a pair of cover members disposed on both sides of the base substrate to prevent the electrode portion and the heating portion from being exposed externally.
A patch-type sensor module is provided. A patch-type sensor module according to one embodiment of the present invention comprises: a base substrate having flexibility and air permeability; an antenna pattern disposed on a first surface of the base substrate; a medicinal solution layer including a functional material and disposed on a second surface of the base substrate; a circuit board electrically connected to the antenna pattern, having at least one driving chip mounted thereon, and disposed on the first surface; and a temperature sensor mounted on the circuit board so as to sense a body temperature of a user.
A patch-type thermometer is provided. A patch-type thermometer according to an exemplary embodiment of the present invention comprises: a flexible circuit board which has an antenna pattern formed on at least one surface thereof and at least one driving chip mounted thereon; a temperature sensor mounted on the flexible circuit board so as to measure a user's body temperature; a heat transfer member electrically connected to the temperature sensor by means of a via hole and mounted on a surface opposite to a surface of the flexible circuit board on which the temperature sensor is mounted, so that the heat transfer member can come into direct contact with a user's skin; and a protective member surrounding the flexible circuit board so as to prevent the antenna pattern, the driving chip, and the temperature sensor from being exposed to the outside.
Three-dimensional micro-environment structure for controlling cell behavior, three-dimensional surface for controlling cell behavior, and method for manufacturing array and three-dimensional micro-environment structure
The present disclosure relates to a three-dimensional micro-environment structure for controlling cell behavior, a three-dimensional surface and an array for controlling cell behavior, and a method for manufacturing the three-dimensional micro-environment structure.
A patch-type sensor module is provided. A patch-type sensor module according to one embodiment of the present invention comprises: a power supply unit electrically connected with a flexible circuit board; a sensing unit which is mounted on the flexible circuit board and includes a temperature sensor for measuring a user's body temperature; a communication unit which allows power to be supplied using a wake-up function, wherein a pairing with an external communication module is concurrently established when power is supplied, and information measured through the sensing unit is then transmitted to the external communication module; a control unit for controlling operations of the power supply unit, the sensing unit, and the communication unit; and a protection member for preventing the flexible circuit board, the power supply unit, the sensing unit, the communication unit, and the control unit from being exposed to the outside.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
H04B 5/00 - Near-field transmission systems, e.g. inductive or capacitive transmission systems
H05K 1/18 - Printed circuits structurally associated with non-printed electric components
H04W 12/47 - Security arrangements using identity modules using near field communication [NFC] or radio frequency identification [RFID] modules
A61B 5/259 - Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes using conductive adhesive means, e.g. gels
The present invention relates to a method for producing a mussel adhesive protein, which is capable of obtaining a mussel adhesive protein with high purity, high yield, and stability, comprising the steps of: expressing a mussel adhesive protein by culturing a microorganism; obtaining an inclusion body comprising the mussel adhesive protein from the microorganism; and obtaining the mussel adhesive protein by using at least one extraction solvent of an organic acid, alcohol, an chaotropic agent, and a sulfoxide compound.
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
Provided is yarn for a cell culture scaffold. The yarn includes ply-twisted fiber strands, and to prevent density-dependent inhibition of cultured cells and increase a cell-contacting specific surface area, at least a part of the plurality of twisted fiber strands are untwisted such that an open space is formed between the fibers. A cell proliferation rate and cell viability may be increased by creating microenvironments suitable for migration, proliferation and differentiation of the cultured cells using the yarn. A large quantity of cells may be simultaneously cultured by creating a cell proliferation space as large as possible in a scaffold space having a limited cell proliferation space, and cell proliferation may be steadily maintained by preventing the inhibition of cell proliferation due to intercellular contact. The cells cultured may be cultured to have a shape/structure suitable for application to an in vitro experiment model or implantation into an animal body.
D02G 1/02 - Producing crimped or curled fibres, filaments, yarns or threads, giving them latent characteristics by twisting, fixing the twist and backtwisting, i.e . by imparting false twist
C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
48.
METHOD FOR MANUFACTURING BLENDED FILAMENT YARN FOR CELL CULTURE SUPPORT, BLENDED FILAMENT YARN FOR CELL CULTURE SUPPORT REALIZED THERETHROUGH, AND FABRIC COMPRISING SAME
Provided is a method for manufacturing a blended filament yarn for a cell culture support. The method for manufacturing a blended filament yarn according to one embodiment of the present invention is performed by comprising the steps of: (1) preparing a first yarn having at least one of a first motif and a first motif conjugate having an amino acid sequence in which a first amino acid sequence motif is repeated at least twice, and a second yarn having at least one of a second motif, which is different from the first motif, and a second motif conjugate having an amino acid sequence in which a second amino acid sequence motif is repeated at least twice, respectively; and (2) plying the prepared first yarn and second yarn. According to this, different motifs are provided in a unitary blended filament yarn, and the blended filament yarn is very suitable for fully expressing each function of the motifs. Also, such a unitary blended filament yarn may make it possible to implement a micro environment in which the steps of attachment, migration, proliferation, and differentiation of cultured cells can take place continuously. Furthermore, it is possible to culture cell aggregates formed of cells with the same differentiation step, and at the same time to culture multiple cell aggregates with different differentiation steps through a unitary blended filament yarn. In addition, it is possible to three-dimensionally grow the cultured cells to be more suitable for application for in vitro experimental models or implantation in animal bodies, and thus the present invention may be widely applied to various products used in the field of cell culturing or tissue engineering such as a bioreactor, a cell culture container, an implantation kit, and the like.
D02G 3/44 - Yarns or threads characterised by the purpose for which they are designed
D02G 3/04 - Blended or other yarns or threads containing components made from different materials
D03D 1/00 - Woven fabrics designed to make specified articles
D03D 15/00 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used
A multi-layered fabric for a cell culture support is provided. The multi-layered fabric for a cell culture support according to an embodiment of the present invention comprises: a first fabric including a first yarn; and a second fabric, provided on at least one surface of the first fabric, including a second yarn and having an average pore diameter smaller than that of the first fabric. To this end, a micro-environment suitable for attachment, migration, proliferation, and differentiation of cells is realized, such that a cell survival rate is improved, the cells can be three-dimensionally proliferated, and the cultured cells can be easily collected. In addition, even if the yarn constituting the support contains a cell culture improving substance for cell culturing, it is possible to provide an efficient cell culturing environment in which cells can be stably cultured and to prevent detachment of the cultured cells.
D03D 15/00 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used
A cell culture vessel is provided. A cell culture vessel according to an embodiment of the present invention is a cell culture vessel: having therein a reception part that is an inner space receiving a cell culture scaffold; and including a fixing member for fixing the cell culture scaffold onto the bottom surface of the reception part, wherein the fixing member comprises: a first adhesive layer adhering to the bottom surface of the reception part; a second adhesive layer adhering to the bottom surface of the cell culture scaffold; and a support film disposed between the first adhesive layer and the second adhesive layer to perform a support function, and adhesive strength between the second adhesive layer and the cell culture scaffold is realized to be greater than that between the first adhesive layer and the bottom surface of the reception part. Accordingly, the cell culture vessel does not allow the scaffold to wobble during the cell culture, thus preventing the culture medium solution from being unevenly dispersed and the growing cells from migrating and leaning and can provide each of the cells with the same mechanical, physical, and chemical stimuli, making a contribution to the uniform growth of the cells. In addition, the cell culture scaffold can be easily separated from the cell culture vessel, whereby the cells can be prevented from being degraded or detached due to biochemical mechanism and cultured cells can be prevented from being damaged by a stimulus beyond necessity. Further, for colony cells that grow forming colonies, the cell culture vessel can prevent the degradation of morphological uniformity over colonies which is caused by a difference in physical and chemical stimuli given to individual colonies during the recovery of the cell culture scaffold.
Provided is a heating patch. The heating patch according to an illustrative embodiment of the present invention comprises: a flexible plate-shaped base substrate; an electrode part including a pair of lead electrodes and pairs of branch electrodes, wherein the lead electrodes are formed in the longitudinal direction on at least one surface of the base substrate and are disposed spaced apart from each other in the width direction of the base substrate, and the branch electrodes respectively extend from the pair of lead electrodes in the width direction of the base substrate in such a way as to overlap with each other for a certain length without being electrically connected to each other; a heating part having a predetermined area so as to be able to electrically connect the pairs of branch electrodes and at the same time generate heat upon being supplied with power, the heating part including a conductive heating material and being disposed in an overlapping region between the pairs of branch electrodes that face each other; and a pair of cover members disposed on both surfaces of the base substrate to prevent the electrode part and the heating part from being exposed to the outside. The heating part comprises a plurality of heating parts disposed spaced apart at predetermined intervals in the longitudinal direction of the base substrate, and the plurality of heating parts are formed so as to have the same resistance.
Provided is a cell culture support, which is a support for attaching and culturing cells, and which includes: a fibrous web which is made by accumulating fibers of a biodegradable polymer and on which a plurality of pores are formed; and a plurality of beads formed on the fibers to secure spaces through which the cells penetrate into the fibrous web and grow therein.
A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
This invention relates to a method of immobilizing a protein on particles, and more particularly to a method of immobilizing an antibody on magnetic particles. The method of immobilizing the protein on the particles can prevent aggregation due to non-specific binding between proteins and between proteins and particles, whereby a relatively small amount of protein can be immobilized on particles.
B01J 31/12 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
Provided is a dry pad, including a wound-covering membrane formed by arranging a fiber containing a hydrophilic polymer that is swollen by an exudate secreted from a wound, a hydrophobic polymer, and a dry wound-healing agent that is released through swelling of the hydrophilic polymer and is difficult to store in a liquid phase, and a first release member, which is a support on which the fiber is arranged and which is separated from the wound-covering membrane.
A61L 15/46 - Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
A61L 15/60 - Liquid-swellable gel-forming materials, e.g. super-absorbents
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
55.
Method of manufacturing superparamagnetic nanocomposite and superparamagnetic nanocomposite manufactured using the same
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (Republic of Korea)
Inventor
Kim, Sung-Il
Choi, Min-Young
Lee, Myoung-Yeol
Lee, Jae-Beom
Tran, Van Tan
Kim, Jeong-Hyo
Oh, Sang-Jin
Abstract
The present invention relates to a method of manufacturing a superparamagnetic nanocomposite and a superparamagnetic nanocomposite manufactured using the same, and more particularly to a method of manufacturing a superparamagnetic nanocomposite suitable for use in magnetic separation for the detection of a target biomaterial and a superparamagnetic nanocomposite manufactured using the same. The method of manufacturing the superparamagnetic nanocomposite according to the present invention has a higher yield and a high rate without complicated processing than a conventional method of manufacturing a magnetic nanoparticle for magnetic separation and is capable of mass production of the superparamagnetic nanocomposite having excellent properties with uniform size and particle size distribution, high aqueous solution dispersibility and high magnetization and being capable of maintaining superparamagnetism.
H01F 1/34 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites
Described is a three-dimensional (3D) microenvironment presenting defined biochemical and physical cues that regulate cellular behavior and use of the microenvironment. A composition to form the 3D microenvironment is provided by combining one or more natural or synthetic polymeric materials and substrate proteins recombinantly or chemically functionalized with a variety of bioactive peptides such as extracellular matrix-derived or growth factor-derived peptides. Also described are devices and methods for screening for optimal combinations of the bioactive motifs in order to create an extracellular microenvironment that can regulate specific cellular behavior such as cell growth, proliferation, migration or differentiation.
Provided is a beauty care pack including: a support; and a membrane that is laminated on the support so as to be separated by moisture, formed by electrospinning a polymer material, a water-soluble polymer material and a functional material, and a dry type, in which the functional material is dissolved by moisture, to thereby enable an easy and convenient storage and package, and enable a convenient use since a dry sheet is attached to the face.
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 7/06 - Interconnection of layers permitting easy separation
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
A45D 44/00 - Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
A45D 40/26 - Appliances specially adapted for applying pasty paint, e.g. using roller, using a ball
B29C 65/56 - Joining of preformed partsApparatus therefor using mechanical means
B29C 65/00 - Joining of preformed partsApparatus therefor
B29D 99/00 - Subject matter not provided for in other groups of this subclass
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
B32B 37/15 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with at least one layer being manufactured and immediately laminated before reaching its stable state, e.g. in which a layer is extruded and laminated while in semi-molten state
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
B32B 37/20 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with all layers existing as coherent layers before laminating involving the assembly of continuous webs only
B32B 37/24 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with at least one layer not being coherent before laminating, e.g. made up from granular material sprinkled onto a substrate
B29K 27/00 - Use of polyvinylhalogenides as moulding material
Provided is a beauty care pack including: a support; a shape retaining layer that is laminated on the support so as to be separated from the support by moisture and is formed by electrospinning a polymer material, to maintain moisturizing and hold the shape of the beauty care pack; and a chemical liquid layer that is laminated on the shape retaining layer and is formed by electrospinning a water-soluble polymer material and a functional material, and that is a dry type and melted by moisture, to thus be easily and conveniently stored and packaged, and conveniently used since the dry sheet is attached on the face of a user.
A dermal adhesive patch is provided. The dermal adhesive patch according to an exemplary embodiment of the present invention is adhered to the skin as a medium for an ampoule containing a mixing ingredient, a drying ingredient, a viscosity control ingredient, and a moisturizing ingredient. The dermal adhesive patch comprises: a backing; and a membrane layer made of a nanofiber web having fine pores so as to block moisture and allow air to pass therethrough and detachably laminated on one surface of the backing.
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
A61K 8/65 - CollagenGelatinKeratinDerivatives or degradation products thereof
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
A45D 44/00 - Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
A45D 44/22 - Face shaping devices, e.g. chin strapsWrinkle removers, e.g. stretching the skin
A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
A patch-type sensor module is provided. A patch-type sensor module according to an exemplary embodiment of the present invention comprises: a base substrate having flexibility and air permeability; an antenna pattern disposed on a first surface of the base substrate; a chemical liquid layer including a functional material and disposed on a second surface of the base substrate; a circuit board electrically connected to the antenna pattern, having at least one driving chip mounted thereon, and disposed on the first surface; and a temperature sensor mounted on the circuit board so as to sense a body temperature of a user.
A patch-type sensor module is provided. A patch-type sensor module according to an exemplary embodiment of the present invention comprises: a power supply unit electrically connected with a flexible circuit board; a sensing unit which is mounted on the flexible circuit board and includes a temperature sensor for measuring a user's body temperature; a communication unit which allows power to be supplied using a wake-up function, wherein a pairing with an external communication module is concurrently established when power is supplied, and information measured through the sensing unit is then transmitted to the external communication module; a control unit for controlling operations of the power supply unit, the sensing unit, and the communication unit; and a protection member for preventing the flexible circuit board, the power supply unit, the sensing unit, the communication unit, and the control unit from being exposed to the outside.
THREE-DIMENSIONAL MICRO-ENVIRONMENT STRUCTURE FOR CONTROLLING CELL BEHAVIOR, THREE-DIMENSIONAL SURFACE FOR CONTROLLING CELL BEHAVIOR, AND METHOD FOR MANUFACTURING ARRAY AND THREE-DIMENSIONAL MICRO-ENVIRONMENT STRUCTURE
The present invention relates to a three-dimensional micro-environment structure for controlling cell behavior, a three-dimensional surface for controlling cell behavior, and a method for manufacturing an array and a three-dimensional micro-environment structure.
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (Republic of Korea)
Inventor
Kim, Sung-Il
Choi, Min-Young
Lee, Myoung-Yeol
Lee, Jae-Beom
Tran, Van Tan
Kim, Jeong-Hyo
Oh, Sang-Jin
Abstract
The present invention relates to a method for producing a superparamagnetic nanocomposite and a superparamagnetic nanocomposite produced using same, and specifically, to a method for producing a superparamagnetic nanocomposite capable of being used for the purpose of magnetic separation for detecting a biological target substance, and a superparamagnetic nanocomposite produced using same. The method for producing a superparamagnetic nanocomposite, according to the present invention, may enable a superparamagnetic nanocomposite having excellent properties such as an even size and particle size distribution, a high degree of aqueous solution dispersibility, a maintained degree of superparamagnetism and a high degree of magnetization to be mass-produced at a high yield, without undergoing a complicated process and at a high speed compared to conventional methods for producing a magnetic nanoparticle for magnetic separation, and the superparamagnetic nanocomposite produced by the method maintains a degree of superparamagnetism and has a high degree of magnetization.
H01F 41/02 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets
H01F 1/20 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials metals or alloys in the form of particles, e.g. powder
B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
64.
Pharmaceutical composition for preventing or treating diabetic complications and screening method for preventive or therapeutic agent for diabetic complications
Kangwon National University University-Industry Cooperation Foundation and (Republic of Korea)
Amolifescience Co., Ltd. (Republic of Korea)
Inventor
Ha, Kwon-Soo
Lee, Yeon-Ju
Abstract
Disclosed are a pharmaceutical composition and a method for preventing or treating diabetic complications caused by vascular leakage, comprising a TGase2 inhibitor, and a method of screening a preventive or therapeutic agent for diabetic complications caused by vascular leakage.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
A61K 9/00 - Medicinal preparations characterised by special physical form
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
Provided is a guide device for injection needle puncture. The guide device for needle puncture according to one embodiment of the present invention comprises: a body; a guide part which has a guide hole provided therein so as to be tilted at a certain angle along the height direction, the guide hole allowing an injection needle to pass therethrough so that during injection needle puncture, the insertion angle of the injection needle can be constantly maintained; and a sliding member which is coupled to the body so as to be slidingly movable, wherein the spaced distance between the guide hole and a medical ultrasound apparatus is adjusted through relative movement of the body or the sliding member so that a target location into which the distal end of the injection needle is inserted can be located on entrance path of the injection needle.
A61M 5/42 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
Provided is a scaffold for cell culture or tissue engineering. The scaffold according to one embodiment of the present invention comprises a fiber web having a three-dimensional network structure and formed by including a biodegradable scaffold fiber. Therefore, cell proliferation rate and survival rate can be improved according to the provision of a microenvironment scaffold suitable for the migration, proliferation, and differentiation of the cells to be cultured. In addition, since the scaffold can be easily removed without physically/chemically stimulating the cells cultured in the scaffold, the recovery of the cultured cells is simple, and the scaffold can be transplanted in vivo while including the cultured cells. Moreover, the shape/structure of the cells to be cultured can be cultured similarly to those of actual animal bodies such that the cultured cells can be more suitably applied, for transplantation, to in vitro experimental models or animal bodies. Furthermore, as the scaffold according to one embodiment of the present invention is modified into a substance for helping the culturing/differentiation of cells, proliferation and survival of the cells can be more improved and the cells to be cultured can be easily implemented into a three-dimensional shape.
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
67.
Beauty care pack and method for manufacturing same
Provided is a beauty care pack including a release film and a beauty care sheet which is separably attached to the release film, wherein the beauty care sheet comprises: a support; a fiber layer which is laminated on the support and in which water-soluble polymers are formed in the form of a nanofiber web; a moisturizing layer which is laminated on the fiber layer and consists of the water-soluble polymers and moisturizing materials; and a beauty care layer which is laminated on the moisturizing layer and in which the water-soluble polymers and functional materials are formed in the form of a nanofiber web, such that active ingredients are absorbed into the skin while being dissolved by moisture.
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
D01D 5/00 - Formation of filaments, threads, or the like
A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
D01F 6/52 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds of polymers of unsaturated carboxylic acids or unsaturated esters
68.
YARN FOR CELL CULTURE SUPPORT, AND FABRIC FOR CELL CULTURE SUPPORT INCLUDING SAME
Provided is a yarn for a cell culture support. The yarn according to an embodiment of the present invention includes a plurality of twisted monofilament strands, wherein at least a portion of the plurality of twisted monofilament strands are untwisted such that spaces are formed between the monofilament strands in order to prevent density-dependent inhibition of cultured cells and increase a specific surface area for cell contact. Accordingly, as a microenvironment yarn appropriate for the movement, proliferation, and differentiation of cells being cultured is realized, the cell proliferation rate and cell survival rate can be enhanced. Also, as a space for cell proliferation is maximally realized in a limited space in the support, a large amount of cells can be simultaneously cultured, and, because phenomenon of the suppression of cell proliferation due to contact between cells is prevented, cell proliferation can steadily continue. Furthermore, cells cultured through the yarn can be cultured in a shape/structure that is more appropriate for being applied to an in vitro experimental model or being implanted in the body of an animal, and can be widely applied in various products used in cell culturing fields or tissue engineering fields such as bioreactors, cell culture containers, or kits for implantation in a body.
D02G 3/26 - Yarns or threads characterised by constructional features with characteristics dependent on the amount or direction of twist
D02G 1/02 - Producing crimped or curled fibres, filaments, yarns or threads, giving them latent characteristics by twisting, fixing the twist and backtwisting, i.e . by imparting false twist
D02G 3/44 - Yarns or threads characterised by the purpose for which they are designed
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
Provided are a cosmetic sheet including: a cosmetic layer configured in the form of a nanofiber web and melted by moisture by electrospinning a water-soluble polymer material and a functional material together; and a moisture retaining layer separably attached to the cosmetic layer and retaining the moisture of the cosmetic layer when wearing the cosmetic layer on the face and performing outdoor activities, to thus prevent moisture from drying out during the time the cosmetic layer is absorbed into the skin, when wearing the cosmetic sheet on the face and taking outdoor activities.
A45D 44/00 - Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
A45D 44/22 - Face shaping devices, e.g. chin strapsWrinkle removers, e.g. stretching the skin
A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
B32B 27/12 - Layered products essentially comprising synthetic resin next to a fibrous or filamentary layer
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
A61F 13/12 - Bandages or dressingsAbsorbent pads specially adapted for the head or neck
Kangwon National University University-industry Cooperation Foundation (Republic of Korea)
AMOLIFESCIENCE CO., LTD. (Republic of Korea)
Inventor
Ha, Kwon-Soo
Kong, Deok-Hoon
Abstract
Disclosed is a method of measuring protein kinase activity, including a) attaching GMBS (N-[γ-maleimidobutyryloxy]sulfosuccinimide ester) to a base plate, b) attaching a substrate that reacts with a protein kinase to the base plate having GMBS attached thereto, thus manufacturing a kit for measuring protein kinase activity, c) introducing, to the kit, a mixture of a sample to be analyzed and a buffer including triton X-100, and d) probing phosphorylation of the substrate caused by the protein kinase contained in the sample, thereby measuring the activity of the protein kinase.
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
71.
SAFETY FILTER, METHOD FOR MANUFACTURING SAME, AND SYRINGE HAVING SAME
A safety filter according to the present invention comprises: a first body, which is connected to a cylinder, and which has a first channel formed therein such that a liquid medicine passes through the same; a second body, which is coupled to the first body in a sealable manner, to which a syringe needle is connected, and which has a second channel formed therein such that the liquid medicine passes through the same; and a filter moving unit, which is mounted between the first body and the second body to be able to slide, which has a filter mounted thereon so as to filter the liquid medicine, and which selectively positions the filter between the first channel and the second channel, wherein, when the liquid medicine is injected into the cylinder, the liquid medicine is prevented from passing through the filter, and, when the liquid medicine is injected into a human body, the liquid medicine is made to pass through the filter.
The present invention relates to a method for immobilising protein of a particle, and more specifically to a method for immobilising antibody onto a magnetic particle. The method for immobilising protein of a particle of the present invention is characterised by a feature of protein not sticking together due to non-specific protein-protein and protein-particle binding so that a relatively small amount of protein can be immobilised onto a particle.
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G01N 33/558 - ImmunoassayBiospecific binding assayMaterials therefor using diffusion or migration of antigen or antibody
B01J 19/10 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing sonic or ultrasonic vibrations
B01J 31/12 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
The present invention relates to a cosmetic sheet comprising: a support; and a membrane which is laminated on the support and attached to skin, and is made by accumulating fibers containing a water-soluble polymer, a water-insoluble polymer, and a functional material for skin care that is released by means of the dissolving of the water-soluble polymer.
The present invention relates to a dry-type pad comprising: a wound membrane which is made by accumulating fibers containing a hydrophobic polymer, a hydrophilic polymer that swells by means of an exudate secreting from a wound, and a dry-type wound healing agent that is released by means of the swelling of the hydrophilic polymer and is difficult to store in a liquid phase; and a first release member which is a support on which the fibers are accumulated, and is separable from the wound membrane.
A cosmetic pack of the present invention comprises: a support; a form retaining layer which is laminated on the support so as to be separated by means of moisture, is formed by electrospinning a polymeric material, retains moisture, and retains the form of the cosmetic pack; and a liquid chemical layer which is laminated on the form retaining layer, is formed by electrospinning a water-soluble polymeric material and a functional material, is a dry-type, and melts by means of moisture, and thus the cosmetic pack is easily and conveniently stored and packaged and is convenient to use since a dry sheet is attached to the face.
A cosmetic pack of the present invention comprises: a support; and a membrane which is laminated on the support so as to be separated by means of moisture, is formed by electrospinning a polymeric material, a water-soluble polymeric material and a functional material, and has the functional material melt by means of moisture, and thus the cosmetic pack is easily and conveniently stored and packaged and is convenient to use since a dry sheet is attached to the face.
KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP. (Republic of Korea)
Inventor
Cho, Ssang-Goo
Baek, Kyuwon
Yang, Gwang-Mo
Kim, Chan
Won, Jihye
Seo, In Yong
Seo, Dong-Sik
Yoo, Chulbae
Goo, Hui-Gwan
Jang, Seonho
Koo, Song Hee
Park, Sang-Eun
Abstract
This disclosure provides for a three-dimensional (3D) microenvironment presenting defined physical or mechanical cues that regulate cellular behavior and use of the matrix. The disclosure also provides for devices and methods for screening for optimal combinations of physical and mechanical cues in order to create a microenvironment that can regulate specific cellular behavior such as cell growth, proliferation, migration or differentiation.
A safety filter of the present invention comprises: a hub mounted at a main body part of a syringe needle so as to be sealable; a tube connected to the hub, and into which a needle part of the syringe needle is inserted; a metal barrel connected to the hub, and into which the tube is inserted; and a filter member mounted at the tube so as to filter foreign matter, and can allow a liquid medicine to smoothly pass through the filter member since the diameter of the metal barrel is reduced and the cross sectional area of the filter member is increased.
A61M 5/165 - Filtering accessories, e.g. blood filters, filters for infusion liquids
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A syringe safety filter of the present invention comprises: a housing separably connected between a syringe needle and a cylinder; a passage member, which has an inflow passage provided at the housing and through which an injection fluid flows into the cylinder, and a discharge passage through which the injection fluid stored in the cylinder is discharged; and a filter member provided at the inflow passage of the passage member so as to filter foreign matter included in the injection fluid, and thus the syringe safety filter can prevent the foreign matter from flowing into the cylinder, and can reduce injection fluid discharge pressure by not allowing the injection fluid to pass through the filter member when the injection fluid is discharged from the cylinder.
The present invention relates to a dental membrane, the dental membrane comprising: a first support which has a plurality of pores formed thereon and is made by the accumulation of first biodegradable-polymer nanofibers which are obtained by means of electrospinning; a second support which has a plurality of pores formed thereon and is made by the accumulation, on the first support, of second biodegradable-polymer nanofibers which are obtained by means of electrospinning and have fiber diameters of a bigger size than the fiber diameters of the first nanofibers; and a third support which has a plurality of pores formed thereon and is made by the accumulation, on the second support, of third biodegradable-polymer nanofibers which are obtained by means of electrospinning and have fiber diameters of a smaller size than the fiber diameters of the second nanofibers.
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
The present invention relates to a cell culture support, which is a support for adhering and culturing cells, the cell culture support comprising: a fiber web which is formed in a manner whereby biodegradable polymeric fiber accumulates, and which has a plurality of pores formed thereon; and a plurality of beads formed on the fiber in order to secure a space where the cells can penetrate into the fiber web to grow.
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
The present invention relates to a cell culture support using a water-soluble polymer. Specifically, the cell culture support using a water-soluble polymer is a support for attaching and culturing cells, wherein the support is formed, through accumulation of fiber which contains a water-soluble polymer and a synthetic polymer and is obtained by means of electro-spinning, as a fiber web having a plurality of pores through which culture fluid permeates, and the water-soluble polymer of the fiber is gradually dissolved in the culture and thereby the diameter of the fiber is slowly reduced, whereby cells can grow and be eluted from the fiber web.
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
83.
CULTURE SUPPORT HAVING IMPROVED CELL ADHESIVENESS AND MOBILITY
The present invention relates to a culture support having improved cell adhesiveness and mobility. The cell culture support is characterized by being formed, through accumulation of fiber which contains a hydrophilic polymer and a hydrophobic polymer and is obtained by means of electro-spinning, as a fiber web having a plurality of pores through which culture fluid permeates.
Provided is a guide device for injection needle puncture. The guide device for injection needle puncture according to one embodiment of the present invention comprises: a body; a guide part which has a guide hole provided therein so as to be tilted at a certain angle along the height direction, the guide hole allowing an injection needle to pass therethrough so that during injection needle puncture, the insertion angle of the injection needle toward the human body is guided and the injection angle can be constantly maintained; and a sliding member which is coupled to the body so as to be slidingly movable, wherein the spaced distance between the guide hole and a medical ultrasound apparatus is adjusted through relative movement of the body or the sliding member so that a target location into which the distal end of the injection needle is inserted can be located on an entrance path of the injection needle.
A61M 5/42 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
A61M 25/06 - Body-piercing guide needles or the like
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
85.
BEAUTY CARE PACK AND METHOD FOR MANUFACTURING SAME
A beauty care pack of the present invention comprises a release film and a beauty care sheet which is separably attached to the release film, wherein the beauty care sheet comprises: a support; a fiber layer which is disposed on the support and in which water soluble polymers are formed in the form of a nanofiber web; a moisturizing layer which is disposed on the fiber layer and consists of the water soluble polymers and moisturizing materials; and a beauty care layer which is disposed on the moisturizing layer and in which the water soluble polymers and functional materials are formed in the form of a nanofiber web, such that active ingredients are absorbed into the skin while being dissolved by moisture.
A beauty sheet of the present invention comprises: a beauty layer molten by moisture and formed in a form of a nano-fiber web by electrospinning a water-soluble high-molecular material and a functional material together; and a moisture-holding layer which is separably attached to the beauty layer and holds moisture of the beauty layer during outdoor activities with the beauty layer attached to a face. When a user performs outdoor activities while the beauty sheet is attached to a face thereof, the beauty sheet can prevent moisture from drying out while being absorbed to the skin. Further, when all of the beauty layer is absorbed to the face and exhausted, the moisture-holding layer is separated from the face, and thus, the beauty sheet is conveniently used.
The present invention relates to a microneedle patch and a production method therefor, the microneedle patch being capable of: reducing production costs by forming a gel layer for supplying a skin care solution by electrospinning or electrospraying; and allowing a drug or the skin care solution to be smoothly absorbed into skin by evenly distributing same on the gel layer for supplying a substance to be delivered. The microneedle patch according to the present invention comprises: a support having a groove formed therein; a plurality of microneedles protruding from the underside of the groove; a gel layer for supplying a substance to be delivered, which consists of a mixture of the substance to be delivered and a biodegradable resin and is filled in a gel state in the groove; and a protective film, which covers the gel layer for supplying the substance to be delivered and is bonded to the support.
The present invention relates to a microneedle patch and a production method therefor, the microneedle patch comprising: a support having a groove formed on one side; a gel layer for supplying a substance to be delivered, which consists of a mixture of the substance to be delivered and a biodegradable resin and is filled in a gel state in the groove; a plurality of microneedles protruding from the other side of the support and perforating skin; a first protective film, which covers the gel layer for supplying the substance to be delivered and is bonded to the support; and a second protective film, which covers the plurality of microneedles and is bonded to the other side of the support, wherein passages are formed to pass through the plurality of microneedles in the support or to pass through the support between the plurality of microneedles so that the substance to be delivered of the gel layer for supplying the substance to be delivered is delivered into the skin.
Disclosed is a method for the prevention or treatment of vascular leakage-induced diseases and diabetic retinopathy, using C-peptide. Found to prevent extravacular leakage by inhibiting VEGF-induced disassembly of VE-cadherin, C-peptide can be applied to the prevention or treatment of various diabetic complications accompanied by vascular leakage.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
91.
Method for prevention or treatment of diabetic angiogenesis impairment using C-peptide
Disclosed are a method and composition for the prevention or treatment of diabetic angiogenesis impairment or diabetic wound-healing impairment, using C-peptide. Found to be able to induce angiogenesis through chemotactic migration of endothelial cells, cell migration to wounded areas, capillary-like network formation, and extracellular signal-regulated kinases 1/2 and Akt phosphorylation and nitric oxide production, C-peptide has prophylactic or therapeutic applications in a broad spectrum of various diabetic complications including diabetic angiogenesis impairment.
A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
92.
Injection nozzle for electrospinning and electrospinning device using same
The present invention relates to an injection nozzle for electrospinning including a nozzle body and an air jacket member detachably coupled with each other, and needle members coupled to the bottom surface of the node body via injection holes of the air jacket member. The electrospinning device basically performs air electrospinning for injecting a fiber solution together with air while discharging the fiber solution through the needle members, and the needle members are exposed at the ends thereof by a length long enough to carry out error-free pure electrospinning without air injection if the air jacket member is separated. Therefore, pure electrospinning or air electrospinning can be selectively carried out.
An injection nozzle for electrospinning including a first nozzle body and a second nozzle body detachably coupled with each other and nozzle members inserted in the first and second nozzle bodies and an electrospinning device using the nozzle. The electrospinning device basically performs air electrospinning wherein a source liquid for fiber is injected together with air while the source liquid for fiber is discharged through the nozzle members, and pure electrospinning without air injection can be efficiently carried out by separating the second nozzle body in such a manner that the lower ends of the nozzle members are exposed for a predetermined length or more. Therefore, according to the present invention, pure electrospinning, air electrospinning or hot air electrospinning may be selectively carried out.
The present invention relates to a membrane for Western blotting which has a three-dimensional open pore structure, an average pore diameter of 0.1-1.0 μm and a thickness of 30-200 μm, wherein the membrane for Western blotting is manufactured by subjecting nanofibers having an average fiber diameter of 50-1000 nm, obtained by electrospinning, to a hot-plate calendering process, and a method for manufacturing the same. The method comprises the steps of: dissolving a hydrophobic material in a solvent to prepare a spinning solution; subjecting the spinning solution to a spinning process to obtain a hydrophobic polymer nanofiber web; and calendering the obtained nanofiber web to obtain a membrane for Western blotting.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 24/00 - Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof
B01D 39/00 - Filtering material for liquid or gaseous fluids
C23C 16/00 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
B29C 67/20 - Shaping techniques not covered by groups , or for porous or cellular articles, e.g. of foam plastics, coarse-pored
B32B 9/04 - Layered products essentially comprising a particular substance not covered by groups comprising such substance as the main or only constituent of a layer, next to another layer of a specific substance
95.
Magnetic core—ceramic shell nanocrystals and manufacturing method thereof
G11B 5/706 - Record carriers characterised by the selection of the material comprising one or more layers of magnetisable particles homogeneously mixed with a bonding agent on a base layer characterised by the composition of the magnetic material
G11B 5/712 - Record carriers characterised by the selection of the material comprising one or more layers of magnetisable particles homogeneously mixed with a bonding agent on a base layer characterised by the surface treatment or coating of magnetic particles
G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods
96.
Bifunctional magnetic core-semiconductor shell nanoparticles and manufacturing method thereof
Provided are bifunctional magnetic core-semiconductor shell nanoparticles and a manufacturing method thereof. The method includes mixing magnetic core material precursors and a reducing agent for the core material precursors; preparing a first mixture solution; heating and cooling the first mixture solution and preparing magnetic core materials; mixing the magnetic core materials with semiconductor shell material precursors and a reducing agent for the semiconductor shell material precursors; preparing a second mixture solution; and heating and cooling the second mixture solution and coating the magnetic core materials with the semiconductor shell materials.
B05D 7/00 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
B32B 5/16 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer formed of particles, e.g. chips, chopped fibres, powder
