Abstract

AMENDMENTS TO THE ABSTRACT AMENDMENTS TO THE ABSTRACT The invention relates to a composition containing, as active ingredient, ectoine, hydroxyectoine and/or salts, esters or amides of these compounds for the treatment and/or prophylaxis of diseases of the eye that are associated with a disturbance of the tear film. The disease can be in particular keratoconjunctivitis sicca. It has been found that, surprisingly, these compounds are capable of preventing a rupture in the outer lipid layer of the tear film, avoiding an undesirably rapid evaporation of the lacrimal fluid.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Goods & Services

Chemical substances, chemical materials and chemical preparations and natural elements, in particular biological preparations for industrial or scientific use; biological preparations for industrial use; biological preparations for scientific use; biological substances [other than for medical or veterinary use]; chemical humectants; chemical substances as adsorbents for inhalation gases; filtering materials of chemical substances; filtering materials of mineral substances; gases for use with aerosols; preservatives for pharmaceutical preparations. Body care preparations; body cleansing and body care preparations; eye and nail care preparations; eye gel pads for cosmetic purposes; eye compresses for cosmetic purposes; eye care preparations, not for medical purposes; eye gels; eye creams; eye gel masks; tanning creams and lotions; skin tightening creams; creams for the prevention of wrinkles; anti-wrinkle creams; moisturizing creams; moisturizing gels; age retardant gels; facial gels; facial creams; facial lotions; facial packs; facial cleansing preparations; facial washes [cosmetics]; facial masks; skin care preparations for wrinkle reduction; hand milks; hand creams; hand lotions; hand cures for skin care; hand lotions, not for medical purposes; skin clarifying lotions, not for medical purposes; cosmetic lotions for strengthening fingernails; cosmetic preparations for wrinkle reduction for application to the face; cosmetic creams for firming skin around eyes; cosmetic facial scrubs; lotions for cosmetic purposes; lotions for cellulite reduction; lotions for aromatherapy; age retardant lotions; lotions for the eyes; lotions against eye wrinkles; shaving lotions; lotions for strengthening fingernails; lotions for use after sunbathing; lotions for application to the skin; body mask lotions; lotions for facial and body care; body and beauty care preparations in the form of lotions; cosmetic preparations for facial care; non-medicated stimulating lotions for the skin; non-medicated cleansing preparations for intimate hygiene; preparations for improving the under-eye area; perfumed lotions [toilet preparations]; beauty care preparations for the face; tissues impregnated with cosmetic lotions; toning lotions for the face, body and hands; vaginal douches for intimate cleansing or deodorizing purposes; all the foregoing goods for purely cosmetic purposes. Eye drops; collyrium and medicated eye washes; anti-inflammatory gels; anti-inflammatory preparations; anti-inflammatory ointments; anti-inflammatory sprays; hygiene preparations and articles; hygiene preparations and articles, in particular medical hygiene preparations; lubricating gels for personal use; silicone-based lubricants for personal use; water-based lubricants for personal use; preparations for use in vaginal lubrication; hygienic lubricants; personal sexual lubricants; inhalants; solutions for medical use for irrigation of the nasal passages; throat lozenges; medicated body gels; medicated body powders; medicated body creams; medicated hand washes; medicated face washes; medicated and disinfectant soaps and detergents; medicated hand lotions: medicated mouth rinses; medicated ointments for use on the skin; medicated ointments for use on the mucous membrane; medicated ointments for use in the eye; medicated sprays; medicated throat sprays; medicated dressings, medical plasters and receptacles for applying medicines; hand creams for medical use; eye pads for medical use; pharmaceutical preparations for ophthalmic use; topical pharmaceutical preparations; intimate cleansing preparations for medical use; preparations for ocular lubrication; nasal decongestants; nasal sprays; nasal drops; nasal drops for the treatment of allergies; pharmaceutical preparations and substances with anti-inflammatory properties; pharmaceutical preparations for the prevention of allergies; solutions for contact lenses; cleaning preparations for contact lenses; contact lense wetting solutions; pharmaceutical throat sprays; cleansing solutions for medical purposes; sprays for reducing swelling of the nasal mucous membrane; sprays for use in the throat; sprays in aerosol form for use on the skin; vaginal douches for medical purposes; vaginal moisturizers; all the foregoing goods for purely medical purpose. Medical and veterinary apparatus and instruments; medical and veterinary apparatus and instruments, in particular dosage dispensers for medical use; eye baths; eye wash cups for medical purposes; eye drop guides; humidifying apparatus for medical use; humidifiers for use with respiratory therapy apparatus; nasal irrigators, electric; electric vaporisers for administering steam inhalants; power operated sprayers for medical purposes; chambers for inhalers; inhalers; apparatus for administering drugs by inhalation; inhalers for medical purposes [sold empty]; inhalers for the evaporation of para-medical substances; medical apparatus for facilitating the inhalation of pharmaceutical preparations; inhalers for medical use; nasal douches; nasal irrigators, non-electric; cooling sprays for medical purposes; nebulisers for medical purposes; sprayers [hand-operated] for medical use; applicators for pharmaceutical preparations.

Goods & Services

Industrial chemicals; chemicals, namely, pyrimidine carboxylic acids; Chemicals for use in biotechnological manufacturing processes; Chemicals for use in biotechnological product development; Chemicals used in industry and science; Chemicals for use in the biochemical and chemical industry; Chemicals for the manufacture of pigments; Chemicals for absorbing water; biological preparations for use in industry; biological preparations for use in science; moistening agents; Synthetic and natural oxides in the form of powders, liquids, pastes and granules; Chemical substances for use as adsorbents in the administration of inhalant gases Cleaning, polishing, scouring and abrasive preparations; Cosmetics; Body and beauty care cosmetics; Skin moisturizers used as cosmetics; Facial lotion; Skin lotion; Hand lotion; Eye lotion; Hair lotions; Toning lotion, for the face, body and hands; non-medicated soaps; Face beauty gels; Skin beauty gel; Hand beauty gels; Eye gels; Eye wrinkle gels; Beauty gels; Skin moisturizing gel; After-sun gels; Topical skin sprays for cosmetic purposes; Anti-wrinkle creams; Wrinkle-minimizing cosmetic preparations for topical facial use Pharmaceutical and veterinary preparations for the treatment of eye diseases; Biological preparations for medical purposes for the treatment of eye diseases; Pharmaceutical preparations and substances for the treatment of eye diseases and conditions, namely, inflammation, viral or bacterial infection of the eye; Pharmaceutical preparations and substances for the treatment of infections in the upper air ways, nose and throat; Pharmaceutical preparations and substances for the treatment of infectious diseases, blood disorders, pain, inflammation, sepsis, alopecia, obesity and cognitive disorders; Vaginal suppositories, cremes and washes for the prevention and treatment of infections; Medicated eye washes; Eye compresses; Eye drops; Medicated eye washes; Eye patches for medical use; Medicated throat lozenges; Medicated throat sprays; Nose drops; Nasal spray preparations; Nose drops for medical purposes; Medicated mouth wash; Medicated mouth spray; Anti-inflammatory sprays; Vaginal washes for medical purposes

Goods & Services

Chemical substances, chemical materials and chemical preparations and natural elements, in particular biological preparations for industrial or scientific use; biological preparations for industrial use; biological preparations for scientific use; biological substances, namely, biological tissue cultures, other than for medical or veterinary use; chemical humectants; chemical substances as adsorbents for inhalation gases for removing impurities; filtering materials of chemical substances in the medical product manufacturing industry; filtering materials of mineral substances in the medical product manufacturing industry; propellant gases for use with aerosols; preservatives for pharmaceutical preparations for use in industry Body care preparations; body cleansing and body care preparations for the skin; eye care preparations in the nature of eye washes and nail care preparations; eye gel pads for cosmetic purposes; eye compresses for cosmetic purposes; eye care preparations in the nature of gels, not for medical purposes; eye gels; eye creams; eye gel masks; tanning creams and lotions; skin tightening creams; creams for the prevention of wrinkles; anti-wrinkle creams; moisturizing creams; moisturizing eye gels; age retardant eye gels; facial moisturizing gels; facial creams; facial lotions; facial packs; facial cleansing preparations; facial washes; facial masks; skin care preparations for wrinkle reduction; hand milks; hand creams; hand lotions; hand cures being lotion for skin care; hand lotions, not for medical purposes; skin clarifying lotions, not for medical purposes; cosmetic lotions for strengthening fingernails; cosmetic preparations for wrinkle reduction for application to the face; cosmetic creams for firming skin around eyes; cosmetic facial scrubs; lotions for cosmetic purposes; lotions for cellulite reduction; body lotions for aromatherapy; age retardant skin lotions; lotions for the eyes; lotions against eye wrinkles; shaving lotions; lotions for strengthening fingernails; lotions for use after sunbathing; lotions for application to the skin; body mask lotions; lotions for facial and body care; body and beauty care preparations in the form of lotions; cosmetic preparations for facial care; non-medicated stimulating lotions for the skin; non-medicated cleansing preparations for intimate personal hygiene; cream preparations for improving the under-eye area; perfumed body lotions; beauty care preparations for the face; tissues impregnated with cosmetic lotions; toning lotions for the face, body and hands; non-medicated vaginal douching preparations for intimate cleansing or deodorizing purposes; all the foregoing goods for purely cosmetic purposes Eye drops; collyrium and medicated eye washes; anti-inflammatory gels; anti-inflammatory preparations; anti­ inflammatory ointments; anti-inflammatory sprays; hygiene preparations, namely, disinfectants for hygiene purposes; hygiene preparations, in particular medical hygiene preparations in the nature of wipes impregnated with disinfectants for hygiene purposes; lubricating gels for personal use; silicone-based lubricants for personal use; water-based lubricants for personal use; preparations for use in vaginal lubrication; hygienic personal lubricants; personal sexual lubricants; ammonia inhalants; saline solutions for medical use for irrigation of the nasal passages; throat lozenges; medicated body gels for dermatological use; medicated body powders for the bath; medicated body creams for skin care; medicated hand washes; medicated face washes; medicated and disinfectant soaps and detergents; medicated hand lotions for skin care: medicated anti-cavity mouth rinses; medicated ointments for use on the skin; medicated ointments for use on the mucous membrane; medicated ointments for use in the eye; medicated acne treatment sprays; medicated throat sprays; medicated dressings and medical plasters for applying medicines; hand creams for skin care for medical use; eye pads for medical use; pharmaceutical preparations for ophthalmic use, namely, medicated eye washes; topical pharmaceutical preparations for the treatment of ocular disorders prescribed by ophthalmologists, eye surgeons, and optometrists; intimate cleansing preparations for medical use, namely, douching preparations; preparations for ocular lubrication; nasal decongestants; nasal sprays for the treatment allergies; nasal drops for the treatment of allergies; pharmaceutical preparations being anti-inflammatories; pharmaceutical preparations for the prevention of allergies; solutions for contact lenses; cleaning preparations for contact lenses; contact lens wetting solutions; pharmaceutical throat sprays; cleansing solutions for medical purposes; anti-inflammatory sprays for reducing swelling of the nasal mucous membrane; sprays for use in the throat; medicated skin care preparations, namely, sprays in aerosol form for use on the skin; vaginal douching preparations for medical purposes; vaginal moisturizers; all the goods for purely medical purpose Medical and veterinary apparatus and instruments, namely, external fixators; medical and veterinary apparatus and instruments, in particular dosage dispensers for medical use; eye baths, namely, eye wash cups for medical purposes; eye wash cups for medical purposes; eye drop guides; humidifying apparatus for medical use; humidifiers for use with respiratory therapy apparatus for medical use; nasal irrigators, electric; electric vaporizers for administering steam inhalants for medical purposes; power operated sprayers for medical purposes for cleaning gums and teeth used in dentists' offices during dental procedures; chambers for inhalers; hydrogen inhalers for medical use, sold empty; apparatus for administering drugs by inhalation, namely, anesthetic masks; inhalers for medical purposes, sold empty; inhalers for medical purposes, sold empty, for the evaporation of para-medical substances; medical apparatus for facilitating the inhalation of pharmaceutical preparations; oxygen inhalers for medical use sold empty; nasal douches being nasal irrigation vessel; nasal irrigators, non-electric; cooling spraying apparatus for medical purposes for treating heatstroke; nebulizers for medical purposes; hand-operated sprayers used for medical and surgical equipment used during medical and surgical procedures; applicators for pharmaceutical preparations, namely, droppers sold empty

Abstract

The present invention relates to the use of organic and highly water-soluble compatible solutes or a solute mixture, preferably in the form of an inhalable, oropharyngeally, nasally and intravenously administrable composition, in the prevention or treatment of diseases caused by ss(+)RNA viruses of the Coronavriridae family, preferably of those diseases caused by SARS-CoV-1, SARS-CoV-2, MERS-CoV, HCoV-HKU1, HCoV-OC43, HCoV-NL63 and/or HCoV-229E. Particularly suitable solutes in the meaning of the invention are ectoine and its derivatives, Glycoin, mannosylglycerate (Firoin) and mannosylglyceramide (Firoin-A), which, due to their strong water-binding capacity, reduce the binding of the viruses to the receptors of the host cell in the transitional epithelium, e.g. eye, in the internal epithelium, e.g. lung, and in the endothelium and thus reduce or prevent the multiplication of the viruses. According to the invention, prevention is enabled by a reduced infectious sputum and breath, and treatment and rehabilitation of the affected tissues is enabled by the membrane protective properties of the compatible solutes according to the invention.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/7032 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
• A61K 31/205 - Amine addition salts of organic acidsInner quaternary ammonium salts, e.g. betaine, carnitine
• A61K 31/4164 - 1,3-Diazoles
• A61K 38/05 - Dipeptides
• A61K 38/06 - Tripeptides
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 31/14 - Antivirals for RNA viruses
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Goods & Services

Industrial chemicals and natural elements, in particular biological preparations for use in industry and in science; biological preparations use in industry; biological preparations for use in science; biological substances [other than for medical or veterinary use]; chemical moistening agents; chemical substances for use as adsorbents for inhalation gases; filter materials of chemical substances; filter materials of mineral substances; gases for use with aerosols; preservatives for use in the pharmaceutical industry. Non-medicated toiletries; cleaning preparations; body cleaning and beauty care preparations; skin, eye and nail care preparations; gel eye patches for cosmetic purposes; eye compresses for cosmetic purposes; eye care products, non-medicated; eye gels; eye cream; gel eye masks; sun-tanning lotions; creams for firming the skin; moisturising creams; moisturising gels [cosmetic]; age retardant gel; anti-wrinkle cream; face gels; face creams for cosmetic use; cosmetic facial masks; cosmetic facial lotions; face packs; facial washes; facial cleansers [cosmetic]; wrinkle removing skin care preparations; hand milks; hand creams; hand lotions; hand masks for skin care; hand lotion (non-medicated -); non-medicated skin clarifying lotions; lotions for strengthening the nails; wrinkle-minimizing cosmetic preparations for topical facial use; cosmetic creams for firming skin around eyes; facial scrubs [cosmetic]; lotions for cosmetic purposes; lotions for cellulite reduction; aromatherapy lotions; age retardant lotion; eye lotions; eye wrinkle lotions; shaving lotion; after-sun lotions; skin lotion; lotions for face and body care; cosmetics in the form of lotions; facial care preparations; non-medicated stimulating lotions for the skin; cleansers for intimate personal hygiene purposes, non medicated; under-eye enhancers; perfumed creams; toning lotion, for the face, body and hands; tissues impregnated with cosmetic lotions; toning lotion, for the face, body and hands; vaginal washes for personal sanitary or deodorant purposes; vaginal washes for personal sanitary or deodorant purposes; all the foregoing articles for purely cosmetic purposes. Medical and veterinary preparations and articles, namely articles in the form of substances which prevent, detect, monitor or alleviate disease; medical and veterinary preparations and articles, namely medicines and natural remedies; biological adjuvants for medical purposes; chemical adjuvants for medical purposes; eye drops; anti-inflammatory gels; anti-inflammatories; anti-inflammatory ointments; anti-inflammatory sprays; gases for medical use; sanitary preparations and articles; sanitary preparations and articles, especially sanitary medical preparations; lubricant gels for personal use; silicone-based personal lubricants; water-based personal lubricants; preparations for use in vaginal lubrication; hygienic lubricants; personal lubricants; inhalants; solutions for medical use in washing the nasal passages; medicated lozenges; medicated body gels; medicated body powder; body creams [medicated]; medicated hand wash; medicated facial wash; medicated and disinfectant soaps and detergents; medicated lotions for the hands; medicated mouthwashes; medicinal ointments; medicated ointments for application to the skin; medicated ointment for application to the mucosa; medicated ointment for use in the eye; medicinal sprays; medicated throat sprays; medical dressings and plasters; hand creams for medical use; medicated eye compresses for medicated use; medicated topical preparations; douching preparations for medical purposes; preparations for ocular lubrication; nasal decongestant; nasal spray; nose drops, pharmaceutical preparations and substances with anti-inflammatory properties; cleansing solutions for medical use; decongestant nasal sprays; sprays for use in the throat; sprays in aerosol form for use on the skin; sterile solutions for medical purposes; drops for medical purpose; sanitary preparations for medical purposes; sanitary preparations and articles, in particular eye baths and eyewashes; vaginal moisturizers; all the foregoing articles for purely medical purposes; medicated eye washes. Medical and veterinary apparatus and instruments; medical and veterinary apparatus and instruments, in particular aerosol dispensers for medical purposes eye wash cups for medical purposes; eye drop guides; humidifying apparatus for medical use; humidifiers for use with respiratory therapy apparatus; nasal irrigators, electric; electric vaporisers for administering steam inhalants; power operated sprayers for medical purposes; chambers for inhalers; inhalers; apparatus for administering drugs by inhalation; inhalers for medical purposes [sold empty]; inhalers for the evaporation of para-medical substances; medical apparatus for facilitating the inhalation of pharmaceutical preparations; inhalers for medical use; nasal douches; nasal irrigators, non-electric; aerosol dispensers for medical purposes; nebulizers for medical use; sprayers [hand-operated] for medical use; applicators for pharmaceutical preparations.

Goods & Services

Industrial chemicals and natural elements, in particular biological preparations for use in industry and in science; biological preparations used in industry; biological preparations for use in science; biological substances [other than for medical or veterinary use]; chemical humidifiers; chemical substances for use as absorbents for inhalation gases; filter materials of chemical substances; filter materials of mineral substances; gases for use with aerosols; preservatives for pharmaceutical preparations. Toiletries; body cleaning and beauty care preparations; skin, eye and nail care preparations; gel eye patches for cosmetic purposes; eye compresses for cosmetic purposes; eye care products, non-medicated; eye gels; eye cream; gel eye masks; sun-tanning creams and lotions; creams for firming the skin; moisturising creams; age retardant gel; anti-wrinkle cream; face gels; face creams for cosmetic use; facial masks; cosmetic facial lotions; face packs; facial washes [cosmetic]; wrinkle removing skin care preparations; hand milks; hand creams; hand lotions; hand masks for skin care; hand lotion (non-medicated -); non-medicated skin clarifying lotions; lotions for strengthening the nails; wrinkle-minimizing cosmetic preparations for topical facial use; cosmetic creams for firming skin around eyes; facial scrubs [cosmetic]; lotions for cosmetic purposes; lotions for cellulite reduction; aromatherapy lotions; age retardant lotion; eye lotions; eye wrinkle lotions; shaving lotion; after-sun lotions; skin lotion; body mask lotion; lotions for face and body care; cosmetics in the form of lotions; facial care preparations; non-medicated stimulating lotions for the skin; cleansers for intimate personal hygiene purposes, non medicated; under-eye enhancers; perfumed lotions [toilet preparations]; beauty tonics for application to the face; tissues impregnated with cosmetic lotions; toning lotion, for the face, body and hands; vaginal washes for personal sanitary or deodorant purposes; all the foregoing articles for purely cosmetic purposes. Medical and veterinary preparations and articles, namely articles in the form of substances which prevent, detect, monitor or alleviate disease; medical and veterinary preparations and articles, namely medicines and natural remedies; biological adjuvants for medical purposes; chemical adjuvants for medical purposes; eye drops; anti-inflammatory gels; anti-inflammatories; anti-inflammatory ointments; anti-inflammatory sprays; gases for medical purposes; sanitary preparations and articles; sanitary preparations and articles, especially sanitary medical preparations; lubricant gels for personal use; silicone-based personal lubricants; water-based personal lubricants; preparations for use in vaginal lubrication; hygienic lubricants; personal lubricants; inhalants; solutions for medical use in washing the nasal passages; lozenges; medicated body gels; medicated body powder; body creams [medicated]; medicated hand wash; medicated facial wash; medicated and disinfectant soaps and detergents; medicated lotions for the hands; medicated mouthwashes; medicinal ointments; medicated ointments for application to the skin; medicated ointment for application to the mucosa; medicated ointment for use in the eye; medicinal sprays; medicated throat sprays; medical dressings and plasters; hand creams for medical use; medicated eye compresses for medicated use; medicated topical preparations; douching preparations for medical purposes; preparations for ocular lubrication; nasal decongestant; nasal spray; nose drops, pharmaceutical preparations and substances with anti-inflammatory properties; cleansing solutions for medical use; decongestant nasal sprays; sprays for use in the throat; sprays in aerosol form for use on the skin; sterile solutions for medical purposes; drops for medical purpose; sanitary preparations for medical purposes; sanitary preparations and articles, in particular eye baths and eyewashes; vaginal moisturizers; all the foregoing articles for purely medical purposes; medicated eye washes. Medical and veterinary apparatus and instruments; medical and veterinary apparatus and instruments, in particular aerosol dispensers for medical purposes eye wash cups for medical purposes; eye drop guides; humidifying apparatus for medical use; humidifiers for use with respiratory therapy apparatus; nasal irrigators, electric; electric vaporisers for administering steam inhalants; power operated sprayers for medical purposes; chambers for inhalers; inhalers; apparatus for administering drugs by inhalation; inhalers for medical purposes [sold empty]; inhalers for the evaporation of para-medical substances; medical apparatus for facilitating the inhalation of pharmaceutical preparations; inhalers for medical use; nasal douches; nasal irrigators, non-electric; aerosol dispensers for medical purposes; nebulizers for medical use; sprayers [hand-operated] for medical use; applicators for pharmaceutical preparations.

Goods & Services

Industrial chemicals and natural elements, in particular biological preparations for use in industry and in science; biological preparations use in industry; biological preparations for use in science; biological substances other than for medical or veterinary use being biological preparations for use in industry and science; chemical moistening agents; chemical substances for use as adsorbents for inhalation gases being chemical adsorbents for removing impurities from fuel; propellant gases for use with aerosols; preservatives for use in the pharmaceutical industry Non-medicated toiletry preparations; Cleaning preparations; Cosmetic preparations; Gel eye patches for cosmetic purposes; Eye compresses for cosmetic purposes; Eye care products, nonmedicated, being non-medicated eye-washes; Eye gels; Eye cream; Gel eye masks; Sun-tanning lotions; Cosmetic preparations, namely, firming creams; Moisturizing creams; Age retardant gel; Anti-wrinkle cream; Face creams for cosmetic use; Cosmetic facial masks; Cosmetic facial lotions; Facial washes; Wrinkle removing skin care preparations; Hand creams; Hand lotions; Hand masks for skin care; Non-medicated hand lotion; Skin clarifiers; Lotions for strengthening the nails; Wrinkle-minimizing cosmetic preparations for topical facial use; Facial scrubs; Lotions for cosmetic purposes; Lotions for cellulite reduction; Essential oil-based creams for aromatherapy use; Age retardant lotion; Eye lotions; Shaving lotion; After-sun lotions; Skin lotion; Lotions for face and body care; Cosmetics in the form of lotions; Facial care preparations, namely, facial cleansers, facial moisturizers; Non-medicated stimulating lotions for the skin; Cleansers for intimate personal hygiene purposes, non medicated; Under-eye enhancers; Perfumed creams; Tissues impregnated with cosmetic lotions; Toning lotion, for the face, body and hands; Vaginal washes for personal sanitary or deodorant purposes Medical and veterinary preparations and articles, namely, pharmaceutical products for treating respiratory disease; Biological and chemical preparations and reagents for medical or veterinary use in the nature of eye drops; Anti-inflammatory gels; Anti-inflammatories; Anti-inflammatory ointments; Anti-inflammatory sprays; Gases for medical use; Sanitary preparations for medical purposes; Silicone-based personal lubricants; Water-based personal lubricants; vaginal lubricants; Personal lubricants; Inhaled pharmaceutical preparations for the treatment of respiratory diseases and disorders; Medicated lozenges; Medicated skin care preparations, namely, creams, lotions, gels and cleaners; Medicated hand wash; Medicated disinfectant; Disinfectant hand soaps; Medicated anti-cavity mouthwashes; Medicated ointments for treating dermatological conditions; Medicated throat sprays; Medical dressings; eye compresses; Douching preparations for medical purposes; Nasal spray preparations; Nose drops; Anti-inflammatory preparations; Cleansing solutions for medical use; Decongestant nasal sprays; Medicated eyewashes; Vaginal washes for medical purposes; Vaginal moisturizers; all the foregoing articles for purely medical purposes; medicated eye washes Eye wash cups for medical purposes; Eye drop guides; Medical apparatus for the treatment of respiratory conditions; Nasal irrigators, electric; Chambers for inhalers; Inhalers for medical purposes, sold empty; Medical apparatus for facilitating the inhalation of pharmaceutical preparations; Hydrogen inhalers for medical use, sold empty; Oxygen inhalers for medical use, sold empty; Nasal irrigators, non-electric; Aerosol dispensers for medical purposes in the nature of inhalers for medical purposes, sold empty; Nebulizers for medical purposes

Goods & Services

Industrial chemicals and natural elements, in particular biological preparations for use in industry and in science; biological preparations use in industry; biological preparations for use in science; biological substances other than for medical or veterinary use being biological preparations for use in industry and science; chemical moistening agents; chemical substances for use as adsorbents for inhalation gases being chemical adsorbents for removing impurities from fuel; propellant gases for use with aerosols; preservatives for use in the pharmaceutical industry Non-medicated toiletry preparations; Cleaning preparations; Cosmetic preparations; Gel eye patches for cosmetic purposes; Eye compresses for cosmetic purposes; Eye care products, nonmedicated, being non-medicated eye-washes; Eye gels; Eye cream; Gel eye masks; Sun-tanning lotions; Cosmetic preparations, namely, firming creams; Moisturizing creams; Age retardant gel; Anti-wrinkle cream; Face creams for cosmetic use; Cosmetic facial masks; Cosmetic facial lotions; Facial washes; Wrinkle removing skin care preparations; Hand creams; Hand lotions; Hand masks for skin care; Non-medicated hand lotion; Skin clarifiers; Lotions for strengthening the nails; Wrinkle-minimizing cosmetic preparations for topical facial use; Facial scrubs; Lotions for cosmetic purposes; Lotions for cellulite reduction; Essential oil-based creams for aromatherapy use; Age retardant lotion; Eye lotions; Shaving lotion; After-sun lotions; Skin lotion; Lotions for face and body care; Cosmetics in the form of lotions; Facial care preparations, namely, facial cleansers, facial moisturizers; Non-medicated stimulating lotions for the skin; Cleansers for intimate personal hygiene purposes, non medicated; Under-eye enhancers; Perfumed creams; Tissues impregnated with cosmetic lotions; Toning lotion, for the face, body and hands; Vaginal washes for personal sanitary or deodorant purposes Medical and veterinary preparations and articles, namely, pharmaceutical products for treating respiratory disease; Biological and chemical preparations and reagents for medical or veterinary use in the nature of eye drops; Anti-inflammatory gels; Anti-inflammatories; Anti-inflammatory ointments; Anti-inflammatory sprays; Gases for medical use; Sanitary preparations for medical purposes; Silicone-based personal lubricants; Water-based personal lubricants; vaginal lubricants; Personal lubricants; Inhaled pharmaceutical preparations for the treatment of respiratory diseases and disorders; Medicated lozenges; Medicated skin care preparations, namely, creams, lotions, gels and cleaners; Medicated hand wash; Medicated disinfectant; Disinfectant hand soaps; Medicated anti-cavity mouthwashes; Medicated ointments for treating dermatological conditions; Medicated throat sprays; Medical dressings; eye compresses; Douching preparations for medical purposes; Nasal spray preparations; Nose drops; Anti-inflammatory preparations; Cleansing solutions for medical use; Decongestant nasal sprays; Medicated eyewashes; Vaginal washes for medical purposes; Vaginal moisturizers; all the foregoing articles for purely medical purposes; medicated eye washes Eye wash cups for medical purposes; Eye drop guides; Medical apparatus for the treatment of respiratory conditions; Nasal irrigators, electric; Chambers for inhalers; Inhalers for medical purposes, sold empty; Medical apparatus for facilitating the inhalation of pharmaceutical preparations; Hydrogen inhalers for medical use, sold empty; Oxygen inhalers for medical use, sold empty; Nasal irrigators, non-electric; Aerosol dispensers for medical purposes in the nature of inhalers for medical purposes, sold empty; Nebulizers for medical purposes

Abstract

The invention relates to a composition containing, as active ingredient, ectoine, hydroxyectoine and/or salts, esters or amides of these compounds for the treatment and/or prophylaxis of diseases of the eye that are associated with a disturbance of the tear film. The disease can be in particular a keratoconjunctivitis sicca. It has been found that, surprisingly, these compounds are capable of preventing a rupture in the outer lipid layer of the tear film, avoiding an undesirably rapid evaporation of the lacrimal fluid.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Abstract

The present invention relates to the use of organic and highly water-soluble compatible solutes or of a solute mixture, preferably in the form of an inhalable composition suitable for oropharyngeal, nasal and intravenous administration, in the prevention or treatment of diseases caused by ss(+)RNA viruses of the Coronaviridae family, preferably diseases caused by SARS-CoV-1, SARS-CoV-2, MERS-CoV, HCoV-HKU1, HCoV-OC43, HCoV-NL63 and/or HCoV-229E. Particularly suitable solutes according to the invention are ectoine and its derivatives, glycoin, mannosylglycerate (firoin) and mannosylglyceramide (firoin-A), which, by virtue of their strong water-binding capacity, reduce the binding of the viruses to the receptors of the host cell in the transitional epithelium, e.g. eye, in the inner epithelium, e.g. lung, and in the endothelium and thus reduce or prevent the reproduction of the virus. According to the invention, prevention is made possible by sputum and breath which are less infectious, and treatment and rehabilitation of the affected tissues are made possible by the membrane-protecting properties of the compatible solutes according to the invention.

IPC Classes  ?

• A61K 9/12 - AerosolsFoams
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/7028 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61M 15/00 - Inhalators
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The invention relates to a composition containing as active agent ectoine, hydroxyectoine, glucosylglycerol and/or salts, esters or amides of these compounds for promoting the regeneration of injured body tissue. The invention has special significance for the treatment of chronic wounds or ulcers.

IPC Classes  ?

• A61K 31/7032 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07D 239/06 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
• C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical

Goods & Services

Chemical preparations for use in industry; chemicals used in science; chemical products for the preparation of odorous products; chemicals for use as ingredients in the course of manufacture; chemical products for diagnostic use; chemical products for biotechnological purposes; chemicals for use in the agrochemical industry; chemical products for the manufacture of cosmetics; chemical products for the manufacture of toilet preparations; chemical products for the manufacture of medical products; chemical products for the preparation of perfumes; chemical preparations for use in the food industry; chemicals used for the formulation of hair treatment products; chemicals for use in the pharmaceutical industry; chemicals for use in agriculture, horticulture and forestry; chemical substances for preserving solvents. Preparations for body and beauty care; cosmetics; cosmetics for animals; cosmetic preparations; sun care preparations; sun-tanning preparations [cosmetics]; skin care preparations; moisturising preparations; cosmetic moisturisers; cosmetic preparations for baths; hair nourishers; tooth care preparations; soap; perfumery; ethereal oils; cosmetics containing hyaluronic acid; cosmetics containing panthenol; after-sun preparations; skin cleansers; anti-aging moisturisers used as cosmetics; cosmetic preparations for the hair and scalp; cosmetic preparations for the care of mouth and teeth; face creams for cosmetic use; facial washes [cosmetic]; face oils; face gels; shampoos for pets [non-medicated grooming preparations]; animal grooming preparations; skin care products for animals; preparations and products for fur care; conditioning sprays for animals; cosmetic preparations for animals; dental care preparations for animals. Pharmaceutical preparations and substances; pharmaceuticals; veterinary preparations; medicated throat sprays; pharmaceutical moisturising creams and moisturising lotions; pharmaceutical drugs; pharmacological preparations for skin care; dermatological pharmaceutical products; pharmaceutical preparations for skin care; pharmaceutical preparations for hair care; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of inflammatory diseases; tissue-regenerative pharmaceutical preparations; ocular pharmaceuticals; pharmaceutical preparations for the prevention and treatment of eye disorders and eye diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases; pharmaceutical preparations for the prevention and treatment of asthma; pharmaceutical preparations for the prevention and treatment of viral diseases; pharmaceutical preparations for use in organ transplantation; pharmaceutical preparations and substances with anti-inflammatory properties; pharmaceutical preparations for the prevention and treatment of allergic rhinitis; pharmaceutical preparations for the prevention and treatment of gastro-intestinal diseases; ointments for pharmaceutical purposes; pharmaceutical preparations for animals; pharmaceutical preparations for inhalers; body gels and body creams for pharmaceutical use; lotions for pharmaceutical purposes; pharmaceutical preparations for treating sunburn; dermatological pharmaceutical substances; pharmaceutical preparations for veterinary use; dietary supplements for humans and animals; medical dressings; insecticidal animal shampoos; vitamin supplements for animals; protein supplements for animals; medicines for veterinary purposes; food supplements for animals; nutraceutical preparations for animals; medicated supplements for foodstuffs for animals; dietary supplements for animals.

Goods & Services

Chemical preparations for use in industry; chemicals used in science; chemical products for the preparation of odorous products, namely, chemicals for use in the manufacture of odorous products in the chemical industry, the cosmetics industry, the pharmaceutical industry and the food industry; chemicals for use as ingredients in the course of manufacture of chemical reagents other than for medical or veterinary purposes and chemical additives, namely, glucosyl glycerol, ectoine and hydroxyectoine for use in further manufacture of cosmetics and pharmaceuticals; chemical products for diagnostic use, namely, chemicals in the nature of reagents other than for medical or veterinary purposes and chemical additives, namely, glucosyl glycerol, ectoine and hydroxyectoine; chemical products for biotechnological purposes, namely, chemical preparations for stabilizing biomolecules; chemicals for use in the agrochemical industry, namely, agricultural chemicals, except fungicides, herbicides, insecticides and parasiticides; chemicals for use in the manufacture of cosmetics; chemicals for use in the manufacture of toilet preparations; chemicals for use in manufacture of medical products; chemicals for use in the manufacture of perfumes; chemical preparations for use in the food industry, namely, chemical products for the fresh-keeping and preserving of food, chemical preparations for cleaning purposes in the food and food processing industries, chemical additives for use in the manufacture of food; chemicals for use in the manufacture of hair treatment products; chemical preparations for use in the pharmaceutical industry; chemicals for use in agriculture, horticulture and forestry except fungicides, herbicides, insecticides and parasiticides; chemical substances for preserving solvents, namely, glucosyl glycerol, ectoine and hydroxyectoine Cosmetic preparations for body and beauty care; cosmetics; cosmetics for animals; cosmetic preparations; non-medicated sun care preparations; sun-tanning preparations; non-medicated skin care preparations; moisturizing preparations for the skin; skin anti-aging moisturizers used as cosmetics; cosmetic preparations for baths; hair nourishers; tooth care preparations, namely, tooth whitening preparations, tooth cleaning preparations, tooth bleaching preparations; non-medicated soap; perfumery; ethereal oils; cosmetics containing hyaluronic acid; cosmetics containing panthenol; after-sun preparations, namely, after sun cream, after-sun gels, after-sun oils, after-sun milks; skin cleansers; anti-aging moisturizers used as cosmetics; cosmetic preparations for the hair and scalp; cosmetic preparations for the care of mouth and teeth; face creams for cosmetic use; facial washes; face oils; face gels for cosmetic purposes; non-medicated grooming preparations, namely, shampoos for pets; non-medicated animal grooming preparations for pets and livestock, namely, cosmetics for pets and livestock; skin care products for animals, namely, cosmetics for animals in the nature of non-medicated skin care creams and lotions; non-medicated animal grooming preparations in the nature of preparations and products for fur care for pets and livestock; non-medicated animal grooming preparations in the nature of conditioning sprays for animals, in particular, for pets and livestock, namely, hair conditioner and hair spray; cosmetic preparations for animals; dental care preparations for animals in the nature of non-medicated dental preparations for pets and livestock, namely, toothpaste and preparations for removing plaque Pharmaceutical preparations and substances for the treatment of dry skin and dry mucosa; pharmaceuticals, namely, medicines for the treatment of or protection against illnesses, diseases and conditions induced by air pollution, namely, respiratory, cardiovascular, reduced immunity, increased and chronic fatigue, eye, nose, throat and skin illnesses, diseases and conditions; veterinary preparations for pets and livestock for the treatment of or protection against illnesses, diseases and conditions induced by air pollution, namely, respiratory, cardiovascular, reduced immunity, increased and chronic fatigue, eye, nose, throat and skin illnesses, diseases and conditions; medicated throat sprays; medicated skin care preparations, namely, pharmaceutical moisturizing creams and moisturizing lotions; pharmaceutical drugs in the nature of pharmaceutical preparations and substances for the treatment of or protection against illnesses, diseases and conditions induced by air pollution, namely, respiratory, cardiovascular, reduced immunity, increased and chronic fatigue, eye, nose, throat and skin illnesses, diseases and conditions; pharmacological preparations for skin care, namely, pharmaceutical skin lotions; dermatological pharmaceutical products; pharmaceutical preparations for skin care; pharmaceutical preparations for hair care in the nature of medicated hair care preparations; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of inflammatory diseases; tissue-regenerative pharmaceutical preparations; ocular pharmaceuticals; pharmaceutical preparations for the prevention and treatment of eye disorders and eye diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases; pharmaceutical preparations for the prevention and treatment of asthma; pharmaceutical preparations for the prevention and treatment of viral diseases; pharmaceutical preparations for use in organ transplantation; pharmaceutical preparations and substances with anti-inflammatory properties for the prevention and treatment of illnesses, diseases and conditions induced by air pollution, namely, respiratory, cardiovascular, reduced immunity, increased and chronic fatigue, eye, nose, throat and skin illnesses, diseases and conditions; pharmaceutical preparations for the prevention and treatment of allergic rhinitis; pharmaceutical preparations for the prevention and treatment of gastro- intestinal diseases; ointments for pharmaceutical purposes, namely, medicated creams for treating dermatological conditions; pharmaceutical preparations for animals, namely, pharmaceutical products for skin care for animals, medicated grooming preparations for pets and livestock; pharmaceutical preparations for inhalation via inhalers for the treatment of pulmonary disease; medicated skin care preparations, namely, body gels and body creams for pharmaceutical use; medicated skin care preparations, namely, lotions for pharmaceutical purposes; pharmaceutical preparations for treating sunburn; dermatological pharmaceutical products; pharmaceutical preparations for veterinary use, namely, veterinary preparations for the treatment of or protection against illnesses, diseases and conditions induced by air pollution, namely, respiratory, cardiovascular, reduced immunity, increased and chronic fatigue, eye, nose, throat and skin illnesses, diseases and conditions; dietary supplements for humans and animals; medical dressings; insecticidal animal shampoos; vitamin supplements for animals; protein supplements for animals; medicines for veterinary purposes for pets and livestock, namely, medicines for the treatment of or protection against illnesses, diseases and conditions induced by air pollution, namely, respiratory, cardiovascular, reduced immunity, increased and chronic fatigue, eye, nose, throat and skin illnesses, diseases and conditions; dietary food supplements for animals; nutraceutical preparations for animals, namely, nutraceuticals for use as a dietary supplement for animals; medicated supplements for foodstuffs for animals; dietary supplements for animals

Abstract

A method for increased and permanent production of a natural compound by a microorganism during an exponential growth and during a stationary phase of a culture of the microorganism, the method comprising: enhancing a translation of a target mRNA, wherein the target mRNA comprises a transcript of a target gene, wherein the target gene is encoding the natural compound or a key enzyme involved in a biosynthesis of the natural compound in the microorganism, by replacing a wild type (wt) ribosome binding site (RBS) upstream of the target gene with a synthetic RBS, the synthetic RBS possessing a higher affinity towards a 16S rRNA of a ribosome of the microorganism than the wt RBS; and enhancing a transcription of the target gene by converting an osmotically regulated σ38promoter upstream of the target gene into a stationary σ38promoter, wherein the osmotically regulated σ38 promoter comprises a -35 G-element and a -10 element which are separated from each other by a spacer sequence, by deleting the -35 G element.

IPC Classes  ?

• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/67 - General methods for enhancing the expression
• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
• C12P 17/12 - Nitrogen as only ring hetero atom containing a six-membered hetero ring
• C12P 7/42 - Hydroxy carboxylic acids
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material

Goods & Services

Chemicals used in industry; Chemicals used in science; Chemical products for the preparation of odorous products; Chemicals for use as ingredients in the course of manufacture; Chemical products for diagnostic purposes; Chemical products for biotechnological purposes; Chemicals for use in the agrochemical industry; Chemical products for the manufacture of cosmetics; Chemical products for the manufacture of toilet preparations; Chemicals for manufacturing medical products; Chemical products for the preparation of perfumes; Chemical preparations for use in the food industry; Chemicals used for the formulation of hair treatment products; Chemicals for use in the pharmaceutical industry; Chemical products for agriculture and forestry and for horticulture; Chemical substances for preserving foodstuffs. Cosmetics; Cosmetics; Cosmetics for animals; Cosmetic preparations; Preparations for sun protection; Tanning preparations; Skin care preparations; Moisturising care preparations; Cosmetic moisturisers; Baths (Cosmetic preparations for -); Hair nourishers; Tooth care preparations; Soaps; Perfumery; Essential oils; Cosmetics containing hyaluronic acid; Cosmetics containing panthenol; After-sun preparations; Skin cleansers; Anti-aging moisturizers used as cosmetics; Cosmetic preparations for the hair and scalp; Cosmetic preparations for the care of mouth and teeth; Face creams for cosmetic use; Facial washes [cosmetic]; Face oils; Face gels; Shampoos for pets [non-medicated grooming preparations]; Animal grooming preparations; Skin care products for animals; Preparations and products for fur care; Conditioning sprays for animals; Cosmetics for animals; Dental care preparations for animals. Pharmaceutical preparations and substances; Pharmaceuticals; Veterinary preparations; Medicated throat sprays; Pharmaceutical moisturising creams and moisturising lotions; Pharmaceutical drugs; Pharmacological preparations for skin care; Dermatological pharmaceutical products; Pharmaceutical preparations for skin care; Pharmaceutical preparations for hair care; Pharmaceutical preparations for the prevention and treatment of allergies; Pharmaceutical preparations for the preparations and treatment of inflammatory conditions; Tissue-regenerative pharmaceutical preparations; Ocular pharmaceuticals; Pharmaceutical preparations for prevention and treatment of eye conditions and eye disorders; Pharmaceutical preparations for prevention and treatment of diseases of the respiratory tract; Pharmaceutical preparations for the prevention and treatment of asthma; Pharmaceutical preparations for the prevention and treatment of viruses; Pharmaceutical preparations for use in organ transplantation; Pharmaceutical preparations and substances with anti-inflammatory properties; Pharmaceutical preparations for the prevention and treatment of allergic rhinitis; Pharmaceutical preparations for the prevention and treatment of gastrointestinal disorders; Ointments for pharmaceutical purposes; Pharmaceutical preparations for animals; Pharmaceutical preparations for inhalers; Body gels and body creams for pharmaceutical purposes; Lotions for pharmaceutical purposes; Sunburn preparations for pharmaceutical purposes; Dermatological pharmaceutical substances; Pharmaceutical preparations for veterinary use; Dietary supplements for humans and animals; Dressings, medical; Insecticidal animal shampoo; Vitamin supplements for animals; Protein supplements for animals; Medicines for veterinary purposes; Food supplements for animals; Neutraceutical preparations for animals; Medicated supplements for foodstuffs for animals; Dietary supplements for animals.

Goods & Services

Chemical preparations for use in industry; chemicals used in science; chemical products for the preparation of odorous products; chemicals for use as ingredients in the course of manufacture; chemical products for diagnostic use; chemical products for biotechnological purposes; chemicals for use in the agrochemical industry; chemical products for the manufacture of cosmetics; chemical products for the manufacture of toilet preparations; chemical products for the preparation of perfumes; chemical preparations for use in the food industry; chemicals used for the formulation of hair treatment products; chemicals for use in the pharmaceutical industry; chemicals for use in agriculture, horticulture and forestry; chemical substances for preserving solvents. Preparations for body and beauty care; cosmetics; cosmetic preparations; sun care preparations; sun-tanning preparations [cosmetics]; skin care preparations; moisturising preparations; cosmetic moisturisers; cosmetic preparations for baths; hair nourishers; tooth care preparations; soap; perfumery; ethereal oils; cosmetics containing hyaluronic acid; cosmetics containing panthenol; after-sun preparations; skin cleansers; anti-aging moisturisers used as cosmetics; cosmetic preparations for the hair and scalp; cosmetic preparations for the care of mouth and teeth; face creams for cosmetic use; facial washes [cosmetic]; face oils; face gels. Pharmaceutical preparations and substances; pharmaceuticals; veterinary preparations; medicated throat sprays; pharmaceutical moisturising creams and moisturising lotions; pharmaceutical drugs; pharmacological preparations for skin care; dermatological pharmaceutical products; pharmaceutical preparations for skin care; pharmaceutical preparations for hair care; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of inflammatory diseases; tissue-regenerative pharmaceutical preparations; ocular pharmaceuticals; pharmaceutical preparations for the prevention and treatment of eye disorders and eye diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases; pharmaceutical preparations for the prevention and treatment of asthma; pharmaceutical preparations for the prevention and treatment of viral diseases; pharmaceutical preparations for use in organ transplantation; pharmaceutical preparations and substances with anti-inflammatory properties; pharmaceutical preparations for the prevention and treatment of allergic rhinitis; pharmaceutical preparations for the prevention and treatment of gastro-intestinal diseases; ointments for pharmaceutical purposes; pharmaceutical preparations for animals; pharmaceutical preparations for inhalers; body gels and body creams for pharmaceutical use; lotions for pharmaceutical purposes; pharmaceutical preparations for treating sunburn; dermatological pharmaceutical substances; pharmaceutical preparations for veterinary use; dietary supplements for humans and animals; medical dressings. Commercial information and advice services in the field of preparations for body and beauty care; commercial information and advice services in the field of pharmaceutical products; retail services in relation to cosmetic products; retail services in relation to preparations for body and beauty care; retail services in relation to pharmaceutical products; retail services in relation to chemical products; wholesale services in relation to cosmetic products; wholesale services in relation to preparations for body and beauty care; wholesale services in relation to pharmaceutical products; wholesale services in relation to chemical products; online retail services in relation to cosmetic products; online retail services in relation to preparations for body and beauty care; online retail services in relation to pharmaceutical products; online retail services in relation to chemical products; business management. Research and development services; medical and pharmacological research services; biomedical research services; medical research; biological research; scientific research; pharmaceutical research services; research relating to biotechnology; chemical technological research; research laboratories; cosmetic research; chemical research; advisory services relating to research in the field of science; scientific laboratory services; scientific research relating to skin care preparations and hair care preparations; scientific analysis; providing technical advice in the field of scientific research; preparation of expert evaluations and reports relating to chemical, pharmaceutical and cosmetic research. Medical services; veterinary services; dental services; medical counseling; provision of medical services; consultancy services relating to cosmetics; consultancy in the field of body and beauty care; cosmetic body care services.

Abstract

The invention relates to a composition which contains N-acetyldiaminobutyric acid, a salt or an ester of N-acetyldiaminobutyric acid for use in a method for the treatment of the human or animal body.

IPC Classes  ?

• A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
• A61K 8/44 - Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfurSalts, esters or N-acylated derivatives thereof
• A61Q 19/00 - Preparations for care of the skin
• A61P 17/04 - Antipruritics
• A61P 17/06 - Antipsoriatics
• A61P 11/06 - Antiasthmatics
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations
• A61Q 19/08 - Anti-ageing preparations

Goods & Services

Chemical preparations for use in industry; chemicals used in science; chemical products for the manufacture of odorous products, namely, cosmetic odorous products; chemicals for use as ingredients for the manufacture of cosmetic, pharmaceutical, and food products; chemical products for biotechnological purposes in the manufacture of cosmetic, pharmaceutical, and food products; chemicals for use in the agrochemical industry; chemical additives for the manufacture of cosmetics; chemicals for use in the manufacture of toilet preparations; chemicals for use in the manufacture of perfumes; chemicals for use in the food industry; chemical additives for the manufacture of hair treatment preparations; chemicals for use in the pharmaceutical industry; chemicals for use in agriculture, horticulture and forestry except fungicides, herbicides, insecticides and parasiticides; chemical substances for preserving solvents cosmetic preparations for body and beauty care; cosmetics; cosmetic preparations; sun care preparations; sun-tanning preparations; cosmetic skin care preparations; skin moisturising preparations; cosmetic moisturisers; cosmetic preparations for baths; hair nourishers; cosmetic preparations for the care of mouth and teeth; body soap; perfumery; ethereal oils; non-medicated cosmetics containing hyaluronic acid; cosmetics containing panthenol; after-sun preparations; skin cleansers; anti-aging moisturisers used as cosmetics; cosmetic preparations for the hair and scalp; cosmetic preparations for the care of mouth and teeth; face creams for cosmetic use; facial wash preparations; face moisturizing oils; face gels for cosmetic use Pharmaceuticals, pharmaceutical drugs and pharmaceutical preparations and substances for the treatment of Allergic Rhinitis, Allergic Concunctivitis, Cough and Cold, Common Cold, Atopic Dermatitis, Psoriasis Eczema, Dry Eye Snydrome, Itchy Eye, Tired Eye, Irretable Bowel Disease, Inflammatory Bowel disease, Wound Healing, Inflammation, Rhinitis sicca, Dry Nose, Mucositis, Dry Skin, Sensitive Skin, Anti-Aging, Asthma, Chronic Obstructive Coronary Disease or COPD, Bronchitis, Rhinitis, Rhinosinusitis, Aphtae, Heartburn, Reflux Disease, gastroesophageal reflux disease or GERD, Hoarseness, and animal care; pharmaceutical and veterinary preparations for animal care; medicated throat sprays; pharmaceutical moisturising creams and moisturising lotions; pharmacological preparations for skin care; dermatological pharmaceutical products; pharmaceutical preparations for hair care; pharmaceutical preparations for the prevention and treatment of allergies; pharmaceutical preparations for the prevention and treatment of inflammatory diseases; tissue-regenerative pharmaceutical preparations; ocular pharmaceuticals; pharmaceutical preparations for the prevention and treatment of eye disorders and eye diseases; pharmaceutical preparations for the prevention and treatment of respiratory diseases; pharmaceutical preparations for the prevention and treatment of asthma; pharmaceutical preparations for the prevention and treatment of viral diseases; pharmaceutical preparations for use in organ transplantation; pharmaceutical preparations and substances with anti-inflammatory properties; pharmaceutical preparations for the prevention and treatment of allergic rhinitis; pharmaceutical preparations for the prevention and treatment of gastro-intestinal diseases; ointments for pharmaceutical purposes; pharmaceutical preparations for animals; pharmaceutical preparations for inhalers; body gels and body creams for pharmaceutical use; pharmaceutical preparations for treating sunburn; lotions for pharmaceutical purposes; dermatological pharmaceutical substances; dietary supplements for humans and animals; medical dressings Commercial information and advice services in the field of preparations for body and beauty care; commercial information and advice services in the field of pharmaceutical products; retail store services in the field of cosmetic products; retail store services in the field of preparations for body and beauty care; retail store services in the field of pharmaceutical products; retail store services in the field of chemical products; wholesale store services in the field of cosmetic products; wholesale store services in the field of preparations for body and beauty care; wholesale store services in the field of pharmaceutical products; wholesale store services in the field of chemical products; online retail store services in the field of cosmetic products; online retail store services in the field of preparations for body and beauty care; online retail store services in the field of pharmaceutical products; online retail store services in the field of chemical products; business management Research and development services in the field of cosmetics, nutrition and pharmacy; medical and pharmacological research services; biomedical research services; medical research; biological research; scientific research; pharmaceutical research services; research relating to biotechnology; chemical technological research; research laboratories in the field of cosmetics, nutrition and pharmacy; cosmetic research; chemical research; advisory services relating to research in the field of science; scientific laboratory services; scientific research relating to skin care preparations and hair care preparations; providing technical advice in the field of scientific research Medical services; veterinary services; dentistry services; medical counseling; provision of medical services; consultancy services relating to cosmetic skincare; consultancy in the field of body and beauty care; cosmetic body care services

Abstract

The invention relates to a composition containing ectoine, hydroxyectoine and/or salts, esters or amides of said compounds as an active substance for use in a method for the treatment and/or prevention of gastroesophageal reflux diseases, inflammations of and damage to the gastric mucosa or duodenal mucosa, and/or gastric or duodenal ulcers.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

The invention relates to a composition containing, as active substances, ectoine, hydroxyectoine and/or salts, esters or amides of these compounds for stimulating sirtuin activity, in particular for the treatment of diseases associated with reduced sirtuin activity. This includes, in particular, different aging disorders and diseases which occur in particular in old age or are associated with disturbed cell differentiation or cell growth.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 9/51 - Nanocapsules
• A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• A61P 35/02 - Antineoplastic agents specific for leukemia
• A61P 35/00 - Antineoplastic agents

Goods & Services

Chemicals used in industry; Chemicals used in science; Chemical products for the preparation of odorous products; Chemicals for use as ingredients in the course of manufacture; Chemical products for diagnostic purposes; Chemical products for biotechnological purposes; Chemicals for use in the agrochemical industry; Chemical products for the manufacture of cosmetics; Chemical products for the manufacture of toilet preparations; Chemical products for the preparation of perfumes; Chemical preparations for use in the food industry; Chemicals used for the formulation of hair treatment products; Chemicals for use in the pharmaceutical industry; Chemical products for agriculture and forestry and for horticulture; Chemical substances for preserving foodstuffs. Cosmetics; Cosmetics; Cosmetic preparations; Preparations for sun protection; Tanning preparations; Skin care preparations; Moisturising care preparations; Cosmetic moisturisers; Baths (Cosmetic preparations for -); Hair nourishers; Tooth care preparations; Soaps; Perfumery; Essential oils; Cosmetics containing hyaluronic acid; Cosmetics containing panthenol; After-sun preparations; Skin cleansers; Anti-aging moisturizers used as cosmetics; Cosmetic preparations for the hair and scalp; Cosmetic preparations for the care of mouth and teeth; Face creams for cosmetic use; Facial washes [cosmetic]; Face oils; Face gels. Pharmaceutical preparations and substances; Pharmaceuticals; Veterinary preparations; Medicated throat sprays; Pharmaceutical moisturising creams and moisturising lotions; Pharmaceutical drugs; Pharmacological preparations for skin care; Dermatological pharmaceutical products; Pharmaceutical preparations for skin care; Pharmaceutical preparations for hair care; Pharmaceutical preparations for the prevention and treatment of allergies; Pharmaceutical preparations for the preparations and treatment of inflammatory conditions; Tissue-regenerative pharmaceutical preparations; Ocular pharmaceuticals; Pharmaceutical preparations for prevention and treatment of eye conditions and eye disorders; Pharmaceutical preparations for prevention and treatment of diseases of the respiratory tract; Pharmaceutical preparations for the prevention and treatment of asthma; Pharmaceutical preparations for the prevention and treatment of viruses; Pharmaceutical preparations for use in organ transplantation; Pharmaceutical preparations and substances with anti-inflammatory properties; Pharmaceutical preparations for the prevention and treatment of allergic rhinitis; Pharmaceutical preparations for the prevention and treatment of gastrointestinal disorders; Ointments for pharmaceutical purposes; Pharmaceutical preparations for animals; Pharmaceutical preparations for inhalers; Body gels and body creams for pharmaceutical purposes; Lotions for pharmaceutical purposes; Sunburn preparations for pharmaceutical purposes; Dermatological pharmaceutical substances; Pharmaceutical preparations for veterinary use; Dietary supplements for humans and animals; Dressings, medical. Commercial information and advice for consumers in the field of cosmetics; Commercial information and advice for consumers in the field of pharmaceutical preparations; Retail Trade services of cosmetic products; Retail store services featuring cosmetics; retail services connected with pharmaceutical preparations; Retail services in relation to chemical preparations; Wholesaling in relation to cosmetic preparations; Wholesale store services featuring cosmetics; wholesale services in relation to pharmaceutical products; Wholesaling of chemicals; Online mail order in relation to cosmetic preparations; Online mail order in relation to cosmetics; Online mail order in relation to pharmaceutical preparations; Online mail order in relation to chemical preparations; Business management. Software development and research; Medical and pharmacological research services; Biomedical research services; Medical research; Biological research; Research services; Pharmaceutical research services; Research relating to biotechnology; Chemical technological research; Research laboratories; Cosmetic research; Chemical research; Advisory services relating to science; Laboratory (Scientific -) services; Scientific research into skin and haircare preparations; Scientific analysis; Drawing up of scientific expert reports; Expertise in the field of chemical, pharmaceutical and cosmetic research. Medical services; Veterinary services; Dentistry; Medical counseling; Provision of medical services; Medical reports; Consultancy services concerning cosmetics; Consultancy in the field of body and beauty care; Cosmetic body care services.

Abstract

The present invention relates to a compatible solute or solute mixture and to a composition containing at least one solute or a solute mixture for use in the prevention or treatment of barrier defects in epithelial tissues associated with at least one bio-based noxa, in particular of diseases comprising at least one barrier defect in at least one cell layer of at least one epithelial tissue, wherein at least one solute is selected from compounds of formula I, formula II, the physiologically acceptable salts of formula I and formula II, the stereoisomeric forms of compounds of formula I, formula II and the physiologically acceptable salts of the stereoisomeric forms or a mixture of at least two of the aforementioned compounds. The at least one compatible solute, solute mixture and/or the composition are provided in the form of a cosmetic, medical device, pharmaceutical product, an addition to any of the aforementioned articles of manufacture or as a constituent of an in-vitro diagnostic product (IVD).

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
• A61P 17/16 - Emollients or protectives, e.g. against radiation

Goods & Services

Chemicals for use in industry and science, In particular for the chemical, cosmetics and pharmaceutical industry and the food industry, included in class 1; Chemical substances, chemical materials and chemical preparations, included in class 1; Glucosylglycerol and products containing glucosylglycerol for industrial purposes, in particular for cosmetic and pharmaceutical purposes, included in class 1; Ectoine and products containing ectoine for industrial purposes, in particular for cosmetic and pharmaceutical purposes, included in class 1; Hydroxyectoine and products containing hydroxyectoine for industrial purposes, in particular for cosmetic and pharmaceutical purposes, included in class 1; Products for stabilising biomolecules. Cosmetics; Lotions for hair; Perfumery; Dentifrices; Sun-tanning gels; After-sun oils [cosmetics]; Anti-aging cream; Anti-wrinkle cream; Skin cream; Creams and lotions for treating the scalp, Not for medical purposes; Face creams for cosmetic use; Cosmetic preparations for skin care; Toiletry preparations; Shampoo; Cosmetic sun-protecting preparations; Sun blocking lipsticks [cosmetics]; Cleaning and fragrancing preparations; Dentifrices; Cosmetic skin care preparations. Medicine; Medical products included in class 5; Pharmaceuticals; Veterinary products; Dietary supplement products for medical purposes; Pharmaceutical preparations for treating mucous membranes; Anti-allergy preparations; Antifungal preparations; Bactericides; Chemico-pharmaceutical preparations; Diagnostic preparations for medical and pharmaceutical purposes; Dietetic substances adapted for medical or veterinary use; Vaccines; Medicated mouth spray; Medicated nasal spray preparations; Medicated throat sprays; Preparations for ocular lubrication; Nutritional supplements; Nasal spray for the treatment of allergies; Nasal drops for the treatment of allergies; Pharmaceutical creams; Products for treating allergies; Dermatological preparations; Products for treating respiratory diseases; Products for treating dry mucous membranes; preparations for treating dry eyes; Products for treating colds; Products for treating neurodermatitis; Sunburn preparations for pharmaceutical purposes.

Abstract

The invention relates to a compatible solute or a solute mixture, as well as to a composition containing said solute or solute mixture, for use in the prevention or treatment of cosmetic or pathological efflorescences caused by particulate matter, such as the pigmentation associated with skin ageing, depigmentation, hypopigmentation, hyperpigmentation and changes associated with atrophy in the broadest sense. The solute or solute mixture, and the composition containing said solute or solute mixture, comprises at least one compound of formula I, formula II, the physiologically acceptable salts of formula (I) and formula (II), the stereoisomeric forms of the compound of formula (I), formula (II) and the physiologically acceptable salts of the stereoisomeric forms, said solute mixture comprising at least two of the aforementioned compounds, where in formula (I) and formula (II), R1 = H or alkyl; R2 = H, COOH, COO-alkyl or CO-NH-R5; R3 and R4, independently of one another, are H or OH; R5 = H, alkyl, amino acid groups, dipeptide groups or tripeptide groups, n = 1, 2 or 3, and alkyl corresponds to an alkyl group having C1-C4 carbon atoms.

IPC Classes  ?

• A61K 31/4164 - 1,3-Diazoles
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61P 17/00 - Drugs for dermatological disorders

Abstract

The invention relates to a composition containing, as an active substance, ectoine, hydroxyectoine and/or salts, esters or amides of these compounds, for the treatment and/or prophylaxis of eye diseases that are associated with a disturbance of the tear film. In particular, this can be keratoconjunctivitis sicca. Unexpectedly, these compounds have been shown to be able to prevent rupturing of the outer lipid layer of the tear film and thus avoid an undesired rapid evaporation of lacrimal fluid.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 27/02 - Ophthalmic agents
• A61P 27/04 - Artificial tearsIrrigation solutions

Goods & Services

Chemicals for use in industry and science, in particular for the chemical industry, the cosmetics industry, the pharmaceutical industry and the food industry, included in this class; chemical substances, chemical materials and chemical preparations, included in this class; glucosyl glycerole and products containing glucosyl glycerole for industrial purposes, in particular for cosmetic purposes and pharmaceutical purposes included in this class; ectoine and products containing ectoine for industrial purposes, in particular for cosmetic purposes andpharmaceutical purposes, included in this class; hydroxyectoine and products containing hydroxyectoine for industrial purposes, in particular for cosmetic purposes and pharmaceutical purposes, included in this class; products for stabilizing biomolecules. Preparations for body and beauty care; hair lotions; perfumery; dentifrices; after-sun gels (cosmetics); after-sun oils (cosmetics); anti-aging creams; anti-wrinkle creams; skin creams; creams and lotions for treating the scalp, not for medical purposes; facial creams (cosmetics); cosmetic preparations for skin care; toiletries; shampoo; sun-tanning preparations (cosmetics); sun blocking lipsticks (cosmetics); cleaning and fragrancing preparations; cosmetic products for skin care. Medicines; medicinal products, included in this class; pharmaceutical products; veterinary products; food supplements for medical purposes; pharmaceutical preparations for treating mucous membranes; antiallergics; antifungal preparations; germicides; chemico-pharmaceutical preparations; diagnostic preparations for medical or pharmaceutical purposes; dietetic preparations adapted for medical or veterinary use; vaccines; medicated mouth sprays; medicated nasal sprays; medicated throat sprays; preparations for ocular lubrication; nutritional supplements; nasal sprays for the treatment of allergies; nasal drops for the treatment of allergies; pharmaceutical creams; products for the treatment of allergies; dermatological products; products for treating respiratory diseases; products for treating dry mucous membranes; products for treating dry eyes; products for treating colds or coryzas; products for treating neurodermatitis; sunburn preparations for pharmaceutical purposes.

Goods & Services

Chemicals for use in industry, in particular, for the chemical industry, the cosmetics industry, the pharmaceutical industry and the food industry; chemical reagents other than for medical or veterinary purposes; chemical additives, namely, glucosyl glycerol, ectoine and hydroxyectoine for use in further manufacture of cosmetics and pharmaceuticals; chemical preparations for stabilizing biomolecules [ Body and beauty care cosmetics; body lotion; beauty masks; beauty soap; beauty serums; hair lotions; perfumery; dentifrices; after-sun gels; after-sun oils; anti-aging creams; anti-wrinkle creams; skin creams; non-medicated scalp treatment creams and lotions; facial creams; cosmetic preparations for skin care; non-medicated toiletries; shampoo; cosmetic sun-tanning preparations; lipsticks containing sun block; facial cleansers; soaps for personal use; fragrances; cosmetic products in the form of aerosols for skin care ] [ Medicines for the treatment of or protection against illnesses, diseases and conditions induced by air pollution, namely, respiratory, cardiovascular, reduced immunity, increased and chronic fatigue, and eye, nose, throat and skin illnesses, diseases and conditions; astringents for medicinal purposes; medicinal drinks; pharmaceutical preparations for the treatment of or protection against illnesses, diseases and conditions induced by air pollution, namely, respiratory, cardiovascular, reduced immunity, increased and chronic fatigue, and eye, nose, throat and skin illnesses, diseases and conditions; enzymes for veterinary products; veterinary preparations for the treatment of or protection against illnesses, diseases and conditions induced by air pollution, namely, respiratory, cardiovascular, reduced immunity, increased and chronic fatigue, and eye, nose, throat and skin illnesses, diseases and conditions; food supplements for medical purposes; pharmaceutical preparations for treating mucous membranes; antiallergic medicines; antifungal preparations; germicides; chemico-pharmaceutical preparations for the treatment of or protection against illnesses, diseases and conditions induced by air pollution, namely, respiratory, cardiovascular, reduced immunity, increased and chronic fatigue, and eye, nose, throat and skin illnesses, diseases and conditions; diagnostic preparations for medical and veterinary use; dietetic sugar adapted for medical or veterinary use; vaccines; medicated mouth sprays; medicated nasal sprays; medicated throat sprays; eye drops; ocular pharmaceuticals, namely, preparations for ocular lubrication; nutritional supplements; nasal sprays for the treatment of allergies; nasal drops for the treatment of allergies; pharmaceutical skin creams; allergy tablets; pharmaceutical preparations for treating allergies; dermatological pharmaceutical products; dermatologicals; medicated creams for treating dermatological conditions; pharmaceutical preparations for treating respiratory diseases; respiratory stimulants; pharmaceutical products for treating respiratory diseases; pharmaceutical preparations for treating dry mucous membranes; pharmaceutical preparations for treating dry eyes; preparations for treating colds and related coryza, or inflammation of the mucous membranes; pharmaceutical preparations for treating neurodermatitis; sunburn preparations for pharmaceutical purposes ]

Goods & Services

Chemicals for use in industry and science, In particular for the chemical, cosmetics and pharmaceutical industry and the food industry, included in class 1; Chemical substances for, Chemical agents and Chemical preparations, In class 1; Glucosylglycerol and products containing glucosylglycerol for industrial purposes, in particular for cosmetic and pharmaceutical purposes, included in class 1; Ectoine and products containing ectoine for industrial purposes, in particular for cosmetic and pharmaceutical purposes, included in class 1; Hydroxyectoine and products containing hydroxyectoine for industrial purposes, in particular for cosmetic and pharmaceutical purposes, included in class 1; Products for stabilising biomolecules. Cosmetics; Hair lotions; Perfumery; Dentifrices; After-sun gels [cosmetics]; After-sun oils [cosmetics]; Anti-aging cream; Anti-aging creams; Skin cream; Creams and lotions for treating the scalp, Not for medical purposes; Facial creams [cosmetic]; Cosmetic preparations for skin care; Toiletries; Shampoo; Sun-tanning preparations [cosmetics]; Sun blocking lipsticks [cosmetics]; Cleaning and fragrancing preparations; Cosmetic products for skincare. Medicinal; Medicinal products, In class 5; Pharmaceutical preparations; Veterinary products; Dietary supplement products for medical purposes; Pharmaceutical preparations for treating mucous membranes; Antiallergics; Antifungal preparations; Germicides; Chemico-pharmaceutical preparations; Diagnostic preparations for medical and pharmaceutical purposes; Dietetic substances adapted for medical use or Veterinary purposes; Vaccines; Medicated mouth spray; Medicated nasal sprays; Medicated throat sprays; Preparations for ocular lubrication; Nutritional supplements; Nasal spray for the treatment of allergies; Nasal drops for the treatment of allergies; Pharmaceutical creams; Products for treating allergies; Dermatological preparations; Products for treating respiratory diseases; Products for treating dry mucous membranes; preparations for treating dry eyes; Products for treating colds; Products for treating neurodermatitis; Sunburn preparations for pharmaceutical purposes.

Abstract

The invention relates to a composition containing ectoine, hydroxyectoine, glucosylglycerol and/or salts, esters or amides of said compounds as active substances for promoting the regeneration of injured body tissues The invention relates to, in particular, the treatment of chronic wounds or ulcers.

IPC Classes  ?

• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages

Abstract

The invention relates to a storage solution for the preservation of transplant organs, tissues or organ systems which is based on the known HTK, UW or celsior solutions. According to the invention, it was determined that ischemia and reperfusion damage can be reduced by the addition of ectoine or hydroxyectoine.

IPC Classes  ?

• A01N 1/02 - Preservation of living parts

Abstract

The invention relates to a composition comprising ectoin, hydroxyectoin and/or a salt, ester or amide of these compounds for suppression of anti-apoptotic signals to neutrophilic granulocytes and other cells involved in inflammation. The retarded apoptosis of neutrophiles is a main component for various kinds of inflammation. Administration of ectoin achieves at least partial restoration of the normal apoptosis rate, which is associated with a corresponding improvement in the inflammation symptoms.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

The invention relates to the use of glucosylglycerol or glucosylglycerol esters with a view to increasing the expression of cell protective enzymes for the protection and stabilization of human skin and/or mucous membranes. It has been demonstrated that glucosylglycerol plays an effective role in the stimulation and activation of cell protective enzymes such as superoxide dismutase. It is thus possible in this manner to protect human skin cells effectively against damaging external influences.

IPC Classes  ?

• A61K 31/7032 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
• A61P 17/00 - Drugs for dermatological disorders
• A61P 39/06 - Free radical scavengers or antioxidants
• A61K 8/60 - SugarsDerivatives thereof
• A61Q 19/00 - Preparations for care of the skin

Abstract

The invention relates to an innovative method for synthesis of cyclic amidines. The synthesis starts from a β-, γ- or δ-lactone which is twofold brominated. After esterification of the carboxyl function, the bromine atoms are nucleophilically substituted and the corresponding diamino compound is obtained. The ring closure to the cyclic amidine is accomplished subsequently by reaction with orthoester, imidate or thioimidate. Owing to interposing additional steps for recovery of the diamino compound in enantiomerically pure form, the enantiomers of the cyclic amidines can be stereoselectively synthesized.

IPC Classes  ?

• A61P 17/00 - Drugs for dermatological disorders
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• C07D 233/18 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 239/06 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
• C07D 243/04 - Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3

Abstract

The present invention relates to the use of osmolytes for treating allergic or viral respiratory diseases, e.g. allergic rhinitis (hay fever) as well as rhinovirus and/or adenovirus infections. The invention also relates to a medicament preparation containing one or more compounds from the group of osmolytes. The group of osmolytes used in the invention comprises various low-molecular substances, more specifically ectoine, 4,5,6,7-tetrahydro-2-methyl-1H-[1,3]-diazepine-4-S-carboxylic acid (homoectoine), hydroxyectoine, di-myo-inositol-phosphate (DIP), to cyclic 2,3-diphosphoglycerate (cDPG), 1,1-diglycerol phosphate (DGP), β-mannosylglycerate (firoin), β-mannosylglyceramide (firoin-A), dimannosyl-diinositol phosphate (DMIP), glucosylglycerol, taurine, betaine, citrulline, and/or a derivative, e.g. an acid, salt, or ester of said compounds.

IPC Classes  ?

• A61K 31/185 - AcidsAnhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
• A61K 31/205 - Amine addition salts of organic acidsInner quaternary ammonium salts, e.g. betaine, carnitine
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/66 - Phosphorus compounds

Abstract

The invention relates to a composition containing between 20 and 80 wt. % of glucosylglycerol and between 0.5 and 20 wt. % of at least one monosaccharide and/or disaccharide. Surprisingly, it has been shown that an especially aqueous solution containing a high concentration of glucosylglycerol has an exceptionally high long-term stability. The composition exhibits a bactericidal and fungicidal action.

IPC Classes  ?

• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom

Goods & Services

Chemicals used in industry, science and photography; unprocessed artificial resins, unprocessed plastics; chemical substances for preserving foodstuffs; adhesives used in industry. Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations as well healthcare preparations; dietetic substances adapted for medical use; food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Abstract

The invention relates to the use of glucosylglycerol or glucosylglycerol esters for increasing the expression of cell protective enzymes used for protecting and stabilizing human skin or mucous membranes. It could be demonstrated that glucosylglycerol plays an effective role in stimulating and activating cell protective enzymes such as superoxide dismutase, thus allowing human skin cells to be effectively protected from damaging external influences.

IPC Classes  ?

• A61K 8/60 - SugarsDerivatives thereof
• A61Q 19/00 - Preparations for care of the skin
• A61P 17/00 - Drugs for dermatological disorders

Abstract

The invention relates to an innovative process for the synthesis of cyclic amidines. The synthesis starts from a ß-, γ- or δ-lactone, which is dibrominated. Following esterification of the carboxyl function, the bromine atoms are subjected to nucleophilic substitution to give the corresponding diamino compound. This is followed by ring closure to give the cyclic amidine, by reaction with an orthoester, imidate or thioimidate. Interposing additional steps for obtaining the diamino compound in enantiomerically pure form allows the enantiomers of the cyclic amidines to be synthesized stereoselectively.

IPC Classes  ?

• C07D 233/18 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 239/06 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
• C07D 243/04 - Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61P 17/00 - Drugs for dermatological disorders

Abstract

Tetrahydropyrimidines of the formula in which R is a hydrogen atom or a hydrocarbon radical having up to eight carbon atoms, R’ is hydrogen, OH or OR", and R" is R or COR, where R is defined as above, for use in the prevention or treatment of post-operative inflammatory stress and inflammatory pain.

IPC Classes  ?

• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Goods & Services

Glycosyl glycerol and preparations containing glycosyl glycerol for industrial purposes, including for cosmetic purposes and pharmaceutical purposes as well as for the food and beverages industry.

Abstract

The invention relates to a method for the stereo-specific hydroxylation of α-amino-S-carboxylic acid or α-amino-R-sulfonic acid derivatives to form α-amino-ß-hydroxy-S-carboxylic acid or α-amino-ß-hydroxy-R-sulfonic acid compounds, wherein hydroxyl and acid groups are trans-configured, using microorganisms having a hydroxylase activity in a production medium, wherein the S-carboxylic acid or R-sulfonic acid derivatives are added to the production medium, and are hydroxylated in the microorganism in the presence of oxygen and a co-substrate using osmotically activated transport systems of the microorganism, and are subsequently actively or passively released from the microorganism in order to be extracted from the production medium.

IPC Classes  ?

• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C07D 239/00 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
• C07D 405/00 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom

Abstract

The invention relates to osmolyte-containing preparations for the local treatment of dry mucous membranes. The use of osmolytes for producing a medicament, medical product, or cosmetic product for preventing, treating, and/or nourishing dry mucous membranes is described. The invention relates to topical compositions based on osmolytes to which sodium chloride and/or moisturizer can be optionally added. The group of osmolytes mentioned in the invention comprises various low-molecular substances, in particular ectoine, homoectoine, hydroxyectoine, di-myo-inositol phosphate (DIP), cyclic 2, 3-diphosphoglycerate (cDPG), 1,1-diglycerol phosphate (DGP), ß-mannosylglycerate (firoin), ß-mannosylglyceramide (firoin-A), dimannosyl di-inositol phosphate (DMIP), glucosylglycerol, and/or a derivative, e.g. an acid, salt, or ester, of said compounds.

IPC Classes  ?

• A61K 31/185 - AcidsAnhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
• A61K 31/205 - Amine addition salts of organic acidsInner quaternary ammonium salts, e.g. betaine, carnitine
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/66 - Phosphorus compounds
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

The invention relates to the use of compatible solutes, especially ectoine, hydroxyectoine, di-myo-inositol phosphate (DIP), cyclic 2,3 diphosphoglycerate (cDPG), 1,1-di-glycerol phosphate (DGP), β-mannosylglycerate (firoin), β-mannosylglyceramide (firoin A), proline betaine and/or derivatives as well as combinations thereof for the production of an agent aimed at preventing and treating gastrointestinal and amyloidal diseases, with agents containing said active ingredients being disclosed as well.

IPC Classes  ?

• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/66 - Phosphorus compounds
• A61K 31/683 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
• A61K 31/7032 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides

Abstract

The invention relates to the use of osmolytes for treating allergic or viral respiratory diseases, e.g. allergic rhinitis (hay fever) as well as rhinovirus and/or adenovirus infections. The invention also relates to a medicament preparation containing one or more compounds from the group of osmolytes. The group of osmolytes used in the invention comprises various low-molecular substances, more specifically ectoine, 4,5,6,7-tetrahydro-2-methyl-1H-[1,3]-diazepine-4-S-carboxylic acid (homoectoine), hydroxyectoine, di-myo-inositol-phosphate (DIP), cyclic 2,3- diphosphoglycerate (cDPG), 1,1-diglycerol phosphate (DGP), ß-mannosylglycerate (firoin), ß-mannosylglyceramide (firoin-A), dimannosyl-diinositol phosphate (DMIP), glucosylglycerol, taurine, betaine, citrulline, and/or a derivative, e.g. an acid, salt, or ester of said compounds.

IPC Classes  ?

• A61K 31/185 - AcidsAnhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
• A61K 31/205 - Amine addition salts of organic acidsInner quaternary ammonium salts, e.g. betaine, carnitine
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/66 - Phosphorus compounds
• A61P 11/00 - Drugs for disorders of the respiratory system

Abstract

This invention is based upon the application of compatible solutes to immobilized biological materials or to immobilize in order to improve the technical performance using the same, namely nucleic acid and proteins or biosensors micronets. The above mentioned compatible solutes are selected from a group that includes Mannosylglycerate (MG) and its 3 derivatives manno- sylglyceramide (MGA), -mannosylglycerol (MGOH), and mannosyl-lactate (MGLac), 1,1-di-glycerol phosphate (DGP), ectoin, hydroxyectoin, and or derivatives or combinations thereof. The improved performance of the above mentioned techniques might be due to: a better state of preservation of the material to be immobilized, increasing the life expectancy of the material, and/or decreasing the storage and/or transport requirements, a more efficient and uniform deposition of the material on the support, more efficiency and/or specificity of hybridation of the marked material, all this originating an increase of the signal-to-noise ratio.

IPC Classes  ?

• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions

Goods & Services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.