Goods & Services

Providing investors with financial information; providing investors with financial information regarding business progress, earnings forecasts, and earnings reports; providing financial information via e-mail; providing financial information via e-mail in the fields of business progress, earnings forecasts, and earnings reports; financial information provided by electronic means; financial information in the fields of business progress, earnings forecasts, and earnings reports provided by electronic means; providing a website featuring financial information (Term considered too vague by the International Bureau pursuant to Rule 13 (2) (b) of the Regulations). Providing a website featuring online non-downloadable electronic publications in the nature of reports in the fields of business progress, earnings forecasts, and earnings reports (Term considered too vague by the International Bureau pursuant to Rule 13 (2) (b) of the Regulations).

Abstract

The disclosure provides methods and systems for identifying a subset of compounds in a plurality of compounds. The identifying includes obtaining, for each compound, a vector including a set of elements, where each element includes a measurement of a different feature of an instance of a cell context upon exposure to the compound. The identifying includes performing the obtaining for a plurality of cell contexts, to obtain a plurality of vectors for each compound across different cell contexts. The identifying includes combining the vectors for each compound to form a combined vector for each compound, thereby forming a plurality of combined vectors representing different compounds. The identifying includes pruning the plurality of compounds to the subset of compounds based on a similarity between respective combined vectors in the plurality of combined vectors corresponding to compounds in the plurality of compounds.

IPC Classes  ?

• G16C 20/20 - Identification of molecular entities, parts thereof or of chemical compositions
• G06F 17/16 - Matrix or vector computation
• G16C 20/40 - Searching chemical structures or physicochemical data

Goods & Services

Providing investors with financial information; providing investors with financial information regarding business progress, earnings forecasts, and earnings reports; providing financial information via e-mail; providing financial information via e-mail in the fields of business progress, earnings forecasts, and earnings reports; financial information provided by electronic means; providing financial information relating to business progress, earnings forecasts, and earnings reports provided by electronic means; providing financial information via a website; providing financial information via a website featuring business progress, earnings forecasts, and earnings reports.

Goods & Services

Providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding (Term considered too vague by the International Bureau pursuant to Rule 13(2)(b) of the Regulations); providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding (Term considered too vague by the International Bureau pursuant to Rule 13(2)(b) of the Regulations).

Abstract

The present disclosure relates to systems, non-transitory computer-readable media, and methods for training and utilizing generative machine learning models to generate embeddings from phenomic images (or other microscopy representations). For example, the disclosed systems can train a generative machine learning model (e.g., a masked autoencoder generative model) to generate predicted (or reconstructed) phenomic images from masked version of ground truth training phenomic images. In some cases, the disclosed systems utilize a momentum-tracking optimizer while reducing a loss of the generative machine learning model to enable efficient training on large scale training image batches. Furthermore, the disclosed systems can utilize Fourier transformation losses with multi-stage weighting to improve the accuracy of the generative machine learning model on the phenomic images during training. Indeed, the disclosed systems can utilize the trained generative machine learning model to generate phenomic embeddings from input phenomic images (for various phenomic comparisons).

IPC Classes  ?

• G06T 15/00 - 3D [Three Dimensional] image rendering
• G06T 5/73 - Deblurring; Sharpening
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks

Abstract

The present disclosure relates to systems, non-transitory computer-readable media, and methods for training and utilizing generative machine learning models to generate embeddings from phenomic images (or other microscopy representations). For example, the disclosed systems can train a generative machine learning model (e.g., a masked autoencoder generative model) to generate predicted (or reconstructed) phenomic images from masked version of ground truth training phenomic images. In some cases, the disclosed systems utilize a momentum-tracking optimizer while reducing a loss of the generative machine learning model to enable efficient training on large scale training image batches. Furthermore, the disclosed systems can utilize Fourier transformation losses with multi-stage weighting to improve the accuracy of the generative machine learning model on the phenomic images during training. Indeed, the disclosed systems can utilize the trained generative machine learning model to generate phenomic embeddings from input phenomic images (for various phenomic comparisons).

IPC Classes  ?

• G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
• G06V 10/75 - Image or video pattern matching; Proximity measures in feature spaces using context analysis; Selection of dictionaries
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Goods & Services

Providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding, via an online searchable database; providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding, via an online database.

Abstract

In a method of molecular scaffold hopping an interface of a scheduler computer sends instructions, prepared by the scheduler computer, to a job runner computer to perform a plurality of separate computational tasks. Each of the separate computational tasks includes calculating one or more chemical properties for a query molecule or molecules in a library of molecules. One or more of the plurality of separate computational tasks performed on the job runner computer are preemptible computing instances. Status indicators sent from the job runner computer are received by the interface for each of the plurality of separate computational tasks. The indicators are one of: incomplete, completed, or failed computing instances. The interface resends the instructions to the job runner computer that correspond to the separate computational tasks having the failed computing instance indicator to increase fault-tolerance against the separate computational tasks not attaining the completed computing instance indicator.

IPC Classes  ?

• G16C 20/40 - Searching chemical structures or physicochemical data
• G06F 9/48 - Program initiating; Program switching, e.g. by interrupt
• G06F 9/54 - Interprogram communication
• G06F 11/07 - Responding to the occurrence of a fault, e.g. fault tolerance

Abstract

The present disclosure relates to systems, non-transitory computer-readable media, and methods for utilizing machine learning and digital embedding processes to generate digital maps of biology and user interfaces for evaluating map efficacy. In particular, in one or more embodiments, the disclosed systems receive perturbation data for a plurality of perturbation experiment units corresponding to a plurality of perturbation classes. Further, the systems generate, utilizing a machine learning model, a plurality of perturbation experiment unit embeddings from the perturbation data. Additionally, the systems align, utilizing an alignment model, the plurality of perturbation experiment unit embeddings to generate aligned perturbation unit embeddings. Moreover, the systems aggregate the aligned perturbation unit embeddings to generate aggregated embeddings. Furthermore, the systems generate perturbation comparisons utilizing the perturbation-level embeddings.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G06T 7/00 - Image analysis
• G06V 10/74 - Image or video pattern matching; Proximity measures in feature spaces
• G06V 10/94 - Hardware or software architectures specially adapted for image or video understanding
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

The present disclosure relates to systems, non-transitory computer-readable media, and methods for utilizing machine learning and digital embedding processes to generate digital maps of biology and user interfaces for evaluating map efficacy. In particular, in one or more embodiments, the disclosed systems receive perturbation data for a plurality of perturbation experiment units corresponding to a plurality of perturbation classes. Further, the systems generate, utilizing a machine learning model, a plurality of perturbation experiment unit embeddings from the perturbation data. Additionally, the systems align, utilizing an alignment model, the plurality of perturbation experiment unit embeddings to generate aligned perturbation unit embeddings. Moreover, the systems aggregate the aligned perturbation unit embeddings to generate aggregated embeddings. Furthermore, the systems generate perturbation comparisons utilizing the perturbation-level embeddings.

IPC Classes  ?

• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G06T 7/00 - Image analysis
• G06T 7/35 - Determination of transform parameters for the alignment of images, i.e. image registration using statistical methods
• G06V 10/74 - Image or video pattern matching; Proximity measures in feature spaces
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G16B 40/20 - Supervised data analysis

Goods & Services

Drug discovery services in the field of neuroscience

Abstract

Provided herein are compounds of Formula (I) and Formula (II) and stereoisomers, tautomers, and pharmaceutically acceptable salts or solvates thereof. Also provided are pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition by using the compounds and pharmaceutical compositions.

IPC Classes  ?

• C07D 243/30 - Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings

Abstract

Provided herein are compounds that modulate RMB39 and methods of using the compounds in RMB39-associated disorders, such as cancer (e.g., renal cell carcinoma).

IPC Classes  ?

• C07D 209/14 - Radicals substituted by nitrogen atoms, not forming part of a nitro radical
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07F 9/28 - Phosphorus compounds with one or more P—C bonds
• A61P 35/00 - Antineoplastic agents

Abstract

A method for treating a homologous recombination (HR)-deficient cancer, a homologous recombination (HR)- proficient cancer or a cancer that is resistant to DNA repair and DNA damage response (DDR) inhibitor therapy, such as Poly (ADP-Ribose) Polymerase (PARP) inhibitor therapy, is provided, the method comprising administering to a subject an RNA-binding motif protein 39 (RBM39) degrader, such as an aryl sulfonamide. A DDR inhibitor, such as a PARP inhibitor, may also be administered. A composition comprising a RBM39 degrader, such as an aryl sulfonamide, e.g., E7820 or Compound A, and a DDR inhibitor, such as a PARP inhibitor, is also provided.

IPC Classes  ?

• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/502 - Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
• A61K 31/5025 - Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Goods & Services

(1) Providing investors with financial information; providing investors with financial information regarding business progress, earnings forecasts, and earnings reports; providing financial information via e-mail; providing financial information via e-mail in the fields of business progress, earnings forecasts, and earnings reports; financial information provided by electronic means; providing financial information relating to business progress, earnings forecasts, and earnings reports provided by electronic means; providing financial information via a website; providing financial information via a website featuring business progress, earnings forecasts, and earnings reports.

Goods & Services

(1) Providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding, via an online searchable database; providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding, via an online database.

Goods & Services

(1) Providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding (Term considered too vague by the International Bureau pursuant to Rule 13(2)(b) of the Regulations); providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding (Term considered too vague by the International Bureau pursuant to Rule 13(2)(b) of the Regulations).

Goods & Services

(1) Providing investors with financial information; providing investors with financial information regarding business progress, earnings forecasts, and earnings reports; providing financial information via e-mail; providing financial information via e-mail in the fields of business progress, earnings forecasts, and earnings reports; financial information provided by electronic means; financial information in the fields of business progress, earnings forecasts, and earnings reports provided by electronic means; providing a website featuring financial information (Term considered too vague by the International Bureau pursuant to Rule 13 (2) (b) of the Regulations). (2) Providing a website featuring online non-downloadable electronic publications in the nature of reports in the fields of business progress, earnings forecasts, and earnings reports (Term considered too vague by the International Bureau pursuant to Rule 13 (2) (b) of the Regulations).

Goods & Services

Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; drug use discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (saas) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding via an online searchable database; providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding via an online database.

Goods & Services

Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; drug use discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (saas) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding via an online searchable database; providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding via an online database.

Goods & Services

Providing investors with financial information; Providing investors with financial information regarding business progress, earnings forecasts, and earnings reports; Providing financial information via e-mail; Providing financial information via e-mail in the fields of business progress, earnings forecasts, and earnings reports; Financial information provided by electronic means; Financial information in the fields of business progress, earnings forecasts, and earnings reports provided by electronic means; providing a website featuring financial information Providing a website featuring online non-downloadable electronic publications in the nature of reports in the fields of business progress, earnings forecasts, and earnings reports

Abstract

A method of treating a cancer having one or more mutations in tumour suppressors AXIN1 and/or APC in the WNT pathway in a subject in need thereof is provided wherein the method comprises administering a MEK inhibitor or a pharmaceutically acceptable salt thereof to the subject. The MEK inhibitor may be administered as a single agent or may be combined with treatment with an immune checkpoint inhibitor, such as an inhibitor of PD-1 and/or PD-L1, or a RAF inhibitor.

IPC Classes  ?

• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/4523 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis

Goods & Services

Providing investors with financial information; Providing investors with financial information regarding business progress, earnings forecasts, and earnings reports; Providing financial information via e-mail; Providing financial information via e-mail in the fields of business progress, earnings forecasts, and earnings reports; Financial information provided by electronic means; Financial information in the fields of business progress, earnings forecasts, and earnings reports provided by electronic means; providing a website featuring financial information Providing a website featuring online non-downloadable electronic publications in the nature of reports in the fields of business progress, earnings forecasts, and earnings reports

Abstract

Provided herein are compounds that modulate RMB39 and methods of using the compounds in RMB39-associated disorders, such as cancer (e.g., renal cell carcinoma).

IPC Classes  ?

• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61P 35/00 - Antineoplastic agents
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings

Goods & Services

Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; drug use discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding.

Abstract

Provided herein are compounds of formula (I) that modulate RMB39 and methods of using the compounds in RMB39-associated disorders, such as cancer (e.g., renal cell carcinoma).

IPC Classes  ?

• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• C07D 471/04 - Ortho-condensed systems
• A61P 35/00 - Antineoplastic agents
• A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
• A61K 31/433 - Thiadiazoles
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings

Goods & Services

Providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; Providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding

Goods & Services

Providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; Providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding

Abstract

In a system for identifying a subset of compounds in a plurality of compounds, the identifying includes obtaining via high throughput screening, for each compound, a vector including a set of elements. Each element includes a measurement of a different feature of an instance of a cell context upon exposure to the compound. The obtaining is repeated for a plurality of cell contexts to obtain a plurality of vectors for each compound across different cell contexts. The vectors are combined for each compound to form a combined vector for each compound, thereby forming a plurality of combined vectors representing different compounds. The plurality of compounds is pruned to the subset of compounds based on a similarity between respective combined vectors in the plurality of combined vectors corresponding to compounds in the plurality of compounds. The subset is used as a reduced size smart compound library to perform pharmaceutical drug discovery.

IPC Classes  ?

• G16C 20/20 - Identification of molecular entities, parts thereof or of chemical compositions
• G06F 17/16 - Matrix or vector computation
• G16C 20/40 - Searching chemical structures or physicochemical data

Abstract

One embodiment of the present invention sets forth a technique for training a machine learning model to generate image embeddings for images captured during multiple experiments. The technique includes inputting a batch of images into a plurality of layers in the machine learning model, wherein the batch of images has been sampled from a plurality of images generated via a first experiment. The technique also includes, for at least one layer included in the plurality of layers, computing a set of statistics associated with a plurality of outputs generated by the layer based on the batch of images and normalizing the plurality of outputs based on the statistics. The technique further includes updating a plurality of parameters for each of the plurality of layers based on a set of predictions generated by the first machine learning model from the batch of images and the normalized plurality of outputs.

IPC Classes  ?

• G06N 3/02 - Neural networks
• G06V 10/70 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning
• G06N 20/00 - Machine learning
• G06V 30/19 - Recognition using electronic means
• G06T 1/00 - General purpose image data processing

Abstract

One embodiment of the present invention sets forth a technique for training a machine learning model to generate image embeddings for images captured during multiple experiments. The technique includes inputting a batch of images into a plurality of layers in the machine learning model, wherein the batch of images has been sampled from a plurality of images generated via a first experiment. The technique also includes, for at least one layer included in the plurality of layers, computing a set of statistics associated with a plurality of outputs generated by the layer based on the batch of images and normalizing the plurality of outputs based on the statistics. The technique further includes updating a plurality of parameters for each of the plurality of layers based on a set of predictions generated by the first machine learning model from the batch of images and the normalized plurality of outputs.

IPC Classes  ?

• G06N 20/00 - Machine learning

Goods & Services

(1) Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. (1) Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (saas) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding via an online searchable database; providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding via an online database.

Goods & Services

(1) Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. (1) Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (saas) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding via an online searchable database; providing pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding via an online database.

Goods & Services

(1) Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. (1) Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding.

Abstract

Methods and systems for evaluating a query perturbation, in a cell based assay representing a test state, are provided. Control data points having dimensions representing measurements of different features across control cell aliquots are obtained. Test data points having dimensions representing measurements of different features across test cell aliquots are obtained. A composite test vector is computed between measures of central tendency across the control data points and measures of central tendency across the test data points. Query perturbation data points having dimensions representing measurements of different features across perturbation cell aliquots are obtained. A composite query perturbation vector is computed between measures of central tendency across the control data points and measures of central tendency across the plurality of query perturbation data points.

IPC Classes  ?

• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

Abstract

In a method of molecular scaffold hopping an interface of a scheduler computer sends instructions, prepared by the scheduler computer, to a job runner computer to perform a plurality of separate computational tasks. Each of the separate computational tasks includes calculating one or more chemical properties for a query molecule or molecules in a library of molecules. One or more of the plurality of separate computational tasks performed on the job runner computer are preemptible computing instances. Status indicators sent from the job runner computer are received by the interface for each of the plurality of separate computational tasks. The indicators are one of: incomplete, completed, or failed computing instances. The interface resends the instructions to the job runner computer that correspond to the separate computational tasks having the failed computing instance indicator to increase fault-tolerance against the separate computational tasks not attaining the completed computing instance indicator.

IPC Classes  ?

• G06F 3/00 - Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
• G06F 9/48 - Program initiating; Program switching, e.g. by interrupt
• G06F 9/54 - Interprogram communication
• G06F 11/07 - Responding to the occurrence of a fault, e.g. fault tolerance
• G16C 20/40 - Searching chemical structures or physicochemical data

Goods & Services

Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds Pharmaceutical research and development services; Scientific research and development of pharmaceutical preparations; Pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; Contract research services in support of scientific research and development of pharmaceutical preparations; Technical consultancy and services in relation to technical research in the field of pharmaceuticals; Consultancy in relation to scientific research in the field of pharmaceuticals; Providing medical research and scientific research information in the field of medicine and pharmaceuticals; Drug discovery services; Drug use discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; Providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; Providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding

Goods & Services

Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds Pharmaceutical research and development services; Scientific research and development of pharmaceutical preparations; Pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; Contract research services in support of scientific research and development of pharmaceutical preparations; Technical consultancy and services in relation to technical research in the field of pharmaceuticals; Consultancy in relation to scientific research in the field of pharmaceuticals; Providing medical research and scientific research information in the field of medicine and pharmaceuticals; Drug discovery services; Drug use discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; Providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; Providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding

Goods & Services

Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds Pharmaceutical research and development services; Scientific research and development of pharmaceutical preparations; Pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; Contract research services in support of scientific research and development of pharmaceutical preparations; Technical consultancy and services in relation to technical research in the field of pharmaceuticals; Consultancy in relation to scientific research in the field of pharmaceuticals; Providing medical research and scientific research information in the field of medicine and pharmaceuticals; Drug discovery services; Drug use discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; Providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; Providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding

Goods & Services

(1) Providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; Providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding.

Goods & Services

Providing scientific and technical information from an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; providing scientific and technical information from an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding.

Goods & Services

Downloadable virtual goods, namely, computer programs featuring computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials, all for use in the metaverse, online, and in online virtual worlds. Virtual retail store services featuring virtual computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials; on-line retail store services featuring computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials. Providing online, non-downloadable computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials.

Goods & Services

Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; drug use discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds.

Goods & Services

Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; drug use discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (saas) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds.

Abstract

An acoustic liquid transfer system comprises: a processor; a source holding component configured to hold a source microplate; a destination holding component configured to hold a destination microplate; an acoustic transducer configured to cause liquid to transfer between the source and destination microplates; and a controller configured to direct movements, according to an ordered picklist, of one or more of the: source holding component, destination holding component, and acoustic transducer. The processor is configured to access an initial picklist of a plurality of source/destination pairs; obtain a current source/destination pair on the ordered picklist being created, calculate a plurality of movement metrics between the current source/destination pair and at least some of the plurality of source/destination pairs on the initial picklist but not yet on the ordered picklist, select a next source/destination pair with reference to the movement metrics: and add the next source/destination pair to the ordered picklist.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• G06Q 10/0875 - Itemisation or classification of parts, supplies or services, e.g. bill of materials

Goods & Services

Virtual computer software to diagnose medical conditions; virtual computer software to prescribe medical treatment and prescriptions; virtual computer software to design clinical trials and forecast clinical trial results; virtual computer software to search for clinical trial patients; virtual computer software to analyze medical images; virtual computer software to analyze data and to develop pharmaceutical products and chemical compounds; virtual computer software for pharmaceutical research and development services; virtual computer software for scientific research and development of pharmaceutical preparations; virtual computer software for pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations; virtual computer software for technical consultancy and services in relation to technical research in the field of pharmaceuticals; virtual computer software for consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals; virtual computer software for drug discovery services; virtual computer software for drug use discovery services; virtual computer software for scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals; virtual computer software for conducting and evaluating clinical trials. Virtual retail store services featuring virtual computer software to diagnose medical conditions; virtual retail store services featuring virtual computer software to prescribe medical treatment and prescriptions; virtual retail store services featuring virtual computer software to design clinical trials and forecast clinical trial results; virtual retail store services featuring virtual computer software to search for clinical trial patients; virtual retail store services featuring virtual computer software to analyze medical images; virtual retail store services featuring virtual computer software to analyze data and to develop pharmaceutical products and chemical compounds; virtual retail store services featuring virtual computer software in relation to pharmaceutical research and development services; virtual retail store services featuring virtual computer software in relation to scientific research and development of pharmaceutical preparations; virtual retail store services featuring virtual computer software in relation to pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; virtual retail store services featuring virtual computer software in relation to contract research services in support of scientific research and development of pharmaceutical preparations; virtual retail store services featuring virtual computer software in relation to technical consultancy and services in relation to technical research in the field of pharmaceuticals; virtual retail store services featuring virtual computer software for consultancy in relation to scientific research in the field of pharmaceuticals; virtual retail store services featuring virtual computer software providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials; on-line retail store services featuring computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results; on-line retail store services featuring computer software to search for clinical trial patients, to analyze medical images, to analyze data and to develop pharmaceutical products and chemical compounds; on-line retail store services featuring computer software in relation to pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; on-line retail store services featuring computer software in relation to contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals; on-line retail store services featuring computer software related to consultancy in relation to scientific research in the field of pharmaceuticals; on-line retail store services featuring computer software providing medical research and scientific research information in the field of medicine and pharmaceuticals; on-line retail store services featuring computer software in relation to drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals and conducting and evaluating clinical trials. Entertainment services, namely, providing online, non-downloadable computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results to be used in virtual environments; entertainment services, namely, providing online, non-downloadable computer software to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds to be used in virtual environments; entertainment services, namely, providing online, non-downloadable computer software to pharmaceutical research and development services, scientific research and development of pharmaceutical preparations to be used in virtual environments; entertainment services, namely, providing online, non-downloadable computer software to pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models and controlled environments to be used in virtual environments; entertainment services, namely, providing online, non-downloadable computer software to contract research services in support of scientific research and development of pharmaceutical preparations to be used in virtual environments; entertainment services, namely, providing online, non downloadable computer software to technical consultancy and services in relation to technical research in the field of pharmaceuticals to be used in virtual environments; entertainment services, namely, providing online, non-downloadable computer software to consultancy in relation to scientific research in the field of pharmaceuticals to be used in virtual environments; entertainment services, namely, providing online, non downloadable computer software to providing medical research and scientific research information in the field of medicine and pharmaceuticals to be used in virtual environments; entertainment services, namely, providing online, non-downloadable computer software to drug discovery services, drug use discovery services to be used in virtual environments; entertainment services, namely, providing online,non-downloadable computer software to scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals and conducting and evaluating clinical trials to be used in virtual environments.

Abstract

An electronic monitor can monitor experimental animals in a cage. The cage has one or more walls that enclose a living space for the experimental animals. The electronic monitor is coupled to the cage. The electronic monitor may include a housing adapted to be mechanically coupled to the cage in a predefined position relative to the cage. A substantially sterile barrier is provided between the living space and the external environment in this coupled state. The walls of the cage may include a signal-interface section. An electromagnetic detector may be coupled to the housing to have a line-of-sight through the signal-interface section and into the living space of the cage. The electromagnetic detector is adapted to detect electromagnetic radiation that is transmitted through the signal-interface section. A controller processes a signal received from the electromagnetic detector to determine a status of the experimental animals or the living space.

IPC Classes  ?

• A01K 1/03 - Housing for domestic or laboratory animals
• G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
• A01K 29/00 - Other apparatus for animal husbandry

Goods & Services

(1) Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. (1) Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; drug use discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (saas) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds.

Goods & Services

(1) Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. (1) Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; drug use discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds.

Abstract

In a method of molecular scaffold hopping an interface of a scheduler computer sends instructions, prepared by the scheduler computer, to a job runner computer to perform a plurality of separate computational tasks. Each of the separate computational tasks includes calculating one or more chemical properties for a query molecule or molecules in a library of molecules. One or more of the plurality of separate computational tasks performed on the job runner computer are preemptible computing instances. Status indicators sent from the job runner computer are received by the interface for each of the plurality of separate computational tasks. The indicators are one of: incomplete, completed, or failed computing instances. The interface resends the instructions to the job runner computer that correspond to the separate computational tasks having the failed computing instance indicator to increase fault-tolerance against the separate computational tasks not attaining the completed computing instance indicator.

IPC Classes  ?

• G06F 3/00 - Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
• G16C 20/40 - Searching chemical structures or physicochemical data
• G06F 11/07 - Responding to the occurrence of a fault, e.g. fault tolerance
• G06F 9/54 - Interprogram communication
• G06F 9/48 - Program initiating; Program switching, e.g. by interrupt

Goods & Services

(1) Downloadable virtual goods, namely, computer programs featuring computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials, all for use in the metaverse, online, and in online virtual worlds. (1) Virtual retail store services featuring virtual computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results,to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials; on-line retail store services featuring computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials. (2) Entertainment services, namely, providing online, non-downloadable computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials.

Goods & Services

Downloadable or recorded computer software for data processing for use in diagnosing medical conditions, prescribing medical treatment and prescriptions, designing clinical trials and forecasting clinical trial results, searching for clinical trial patients, analyzing medical images, analyzing data, and developing pharmaceutical products and chemical compounds Pharmaceutical research and development services; Scientific research and development of pharmaceutical preparations; Pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; Research services for others in support of scientific research and development of pharmaceutical preparations; Technical consultancy in relation to technical research in the field of pharmaceuticals; Consultancy in relation to scientific research in the field of pharmaceuticals; Providing medical research and scientific research information in the field of medicine and pharmaceuticals; Drug discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software for data processing for use in diagnosing medical conditions, prescribing medical treatment and prescriptions, designing clinical trials and forecasting clinical trial results, searching for clinical trial patients, analyzing medical images, analyzing data, and developing pharmaceutical products and chemical compounds

Goods & Services

Downloadable or recorded computer software for data processing for use in diagnosing medical conditions, prescribing medical treatment and prescriptions, designing clinical trials and forecasting clinical trial results, searching for clinical trial patients, analyzing medical images, analyzing data, and developing pharmaceutical products and chemical compounds Pharmaceutical research and development services; Scientific research and development of pharmaceutical preparations; Pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; Research services for others in support of scientific research and development of pharmaceutical preparations; Technical consultancy in relation to technical research in the field of pharmaceuticals; Consultancy in relation to scientific research in the field of pharmaceuticals; Providing medical research and scientific research information in the field of medicine and pharmaceuticals; Drug discovery services; Scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software for data processing for use in diagnosing medical conditions, prescribing medical treatment and prescriptions, designing clinical trials and forecasting clinical trial results, searching for clinical trial patients, analyzing medical images, analyzing data, and developing pharmaceutical products and chemical compounds

Goods & Services

(1) Providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; Providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding

Goods & Services

Providing scientific research information and results in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding from an online searchable database; Providing scientific research information and results in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding.

Goods & Services

Providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; Providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding

Goods & Services

Providing an online searchable database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding; Providing an online database in the fields of pharmaceutical research and development, scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds, technical research in the field of pharmaceuticals, drug use, drug discovery, and biology understanding

Abstract

The disclosure provides methods and systems for identifying a subset of compounds in a plurality of compounds. The identifying includes obtaining, for each compound, a vector including a set of elements, where each element includes a measurement of a different feature of an instance of a cell context upon exposure to the compound. The identifying includes repeating the obtaining for a plurality of cell contexts, to obtain a plurality of vectors for each compound across different cell contexts. The identifying includes combining the vectors for each compound to form a combined vector for each compound, thereby forming a plurality of combined vectors representing different compounds. The identifying includes pruning the plurality of compounds to the subset of compounds based on a similarity between respective combined vectors in the plurality of combined vectors corresponding to compounds in the plurality of compounds.

IPC Classes  ?

• G16C 20/20 - Identification of molecular entities, parts thereof or of chemical compositions
• G06F 17/16 - Matrix or vector computation
• G16C 20/40 - Searching chemical structures or physicochemical data

Abstract

Disclosed herein are methods of high-throughput screening test agents for treating a disease. Also disclosed herein are methods of high-throughput screening diseases. Systems for high-throughput screening are also disclosed herein.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

Disclosed herein are methods of high-throughput screening test agents for treating a disease. Also disclosed herein are methods of high-throughput screening diseases. Systems for high-throughput screening are also disclosed herein.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

Disclosed herein are methods of high-throughput screening test agents for treating a disease. Also disclosed herein are methods of high-throughput screening diseases. Systems for high-throughput screening are also disclosed herein.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• G01N 1/30 - Staining; Impregnating
• G01N 15/14 - Electro-optical investigation
• G16H 70/40 - ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage

Abstract

Provided herein are compounds of Formula (I) and Formula (II) and stereoisomers, tautomers, and pharmaceutically acceptable salts or solvates thereof. Also provided are pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition by using the compounds and pharmaceutical compositions.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/5513 - 1,4-Benzodiazepines, e.g. diazepam
• A61P 31/04 - Antibacterial agents
• C07D 243/30 - Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
• C07D 487/04 - Ortho-condensed systems
• C07D 491/04 - Ortho-condensed systems
• C07D 495/04 - Ortho-condensed systems
• C07D 498/04 - Ortho-condensed systems
• C07D 513/04 - Ortho-condensed systems

Goods & Services

Downloadable virtual goods, namely, computer programs featuring computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials, all for use in the metaverse, online, and in online virtual worlds Virtual retail store services featuring virtual computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials; on-line retail store services featuring computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials Entertainment services, namely, providing online, non-downloadable computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds, pharmaceutical research and development services, scientific research and development of pharmaceutical preparations, pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, contract research services in support of scientific research and development of pharmaceutical preparations, technical consultancy and services in relation to technical research in the field of pharmaceuticals, consultancy in relation to scientific research in the field of pharmaceuticals, providing medical research and scientific research information in the field of medicine and pharmaceuticals, drug discovery services, drug use discovery services, scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials

Goods & Services

Downloadable computer programs for data processing for use in diagnosing medical conditions, prescribing medical treatment and prescriptions, designing clinical trials and forecasting clinical trial results, searching for clinical trial patients, analyzing medical images, analyzing data, developing pharmaceutical products and chemical compounds, performing pharmaceutical research and development, performing scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, for use in contract research services in support of scientific research and development of pharmaceutical preparations, for providing technical consultancy and services in relation to technical research in the field of pharmaceuticals, for use in consultancy in relation to scientific research in the field of pharmaceuticals, for providing medical research and scientific research information in the field of medicine and pharmaceuticals, for use in drug discovery services, for use in drug use discovery services, for use in scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials, all for use in the metaverse, online, and in online virtual worlds Online retail store services rendered in a virtual environment featuring downloadable computer programs for use in diagnosing medical conditions, prescribing medical treatment and prescriptions, designing clinical trials and forecasting clinical trial results, searching for clinical trial patients, analyzing medical images, analyzing data, developing pharmaceutical products and chemical compounds, performing pharmaceutical research and development, performing scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, for use in contract research services in support of scientific research and development of pharmaceutical preparations, for providing technical consultancy and services in relation to technical research in the field of pharmaceuticals, for use in consultancy in relation to scientific research in the field of pharmaceuticals, for providing medical research and scientific research information in the field of medicine and pharmaceuticals, for use in drug discovery services, for use in drug use discovery services, for use in scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials; Online retail store services featuring downloadable and online, non-downloadable computer programs for use in diagnosing medical conditions, prescribing medical treatment and prescriptions, designing clinical trials and forecasting clinical trial results, searching for clinical trial patients, analyzing medical images, analyzing data, developing pharmaceutical products and chemical compounds, performing pharmaceutical research and development, performing scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, for use in contract research services in support of scientific research and development of pharmaceutical preparations, for providing technical consultancy and services in relation to technical research in the field of pharmaceuticals, for use in consultancy in relation to scientific research in the field of pharmaceuticals, for providing medical research and scientific research information in the field of medicine and pharmaceuticals, for use in drug discovery services, for use in drug use discovery services, for use in scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials Providing temporary use of online, non-downloadable computer software for data processing for use in diagnosing medical conditions, prescribing medical treatment and prescriptions, designing clinical trials and forecasting clinical trial results, searching for clinical trial patients, analyzing medical images, analyzing data, developing pharmaceutical products and chemical compounds, performing pharmaceutical research and development, performing scientific research and development of pharmaceutical preparations, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments, for use in contract research services in support of scientific research and development of pharmaceutical preparations, for providing technical consultancy and services in relation to technical research in the field of pharmaceuticals, for use in consultancy in relation to scientific research in the field of pharmaceuticals, for providing medical research and scientific research information in the field of medicine and pharmaceuticals, for use in drug discovery services, for use in drug use discovery services, for use in scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, and conducting and evaluating clinical trials

Abstract

The present disclosure describes compounds of Formula (I) and Formula (II) and stereoisomers, tautomers, and pharmaceutically acceptable salts or solvates thereof, wherein all of the variables are as defined herein. This disclosure also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition by using the compounds and pharmaceutical compositions.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61P 31/04 - Antibacterial agents
• C07D 487/04 - Ortho-condensed systems
• C07D 495/04 - Ortho-condensed systems

Abstract

The present disclosure describes compounds of Formula (I) and Formula (II) and stereoisomers, tautomers, and pharmaceutically acceptable salts or solvates thereof, wherein all of the variables are as defined herein. This disclosure also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition by using the compounds and pharmaceutical compositions.

IPC Classes  ?

• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• A61P 31/04 - Antibacterial agents
• A61K 31/5513 - 1,4-Benzodiazepines, e.g. diazepam

Goods & Services

Downloadable computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; Recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. Scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds.

Goods & Services

Downloadable computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; Recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. Scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds.

Abstract

A system for determining a goodness of a deep learning model comprises a memory coupled with a processor. The processor accesses a first set of vectors representative of images of a biological assay. The vectors of the first set of vectors are outputs of a first deep learning model. The processor creates a first distribution of a first plurality of pairwise comparisons of vectors, of the first set of vectors, which were generated from image pairs with similar cell perturbations. The processor creates a second distribution of a second plurality of pairwise comparisons of vectors, of the first set of vectors, which were generated from image pairs with dissimilar cell perturbations. The processor determines a difference between the first distribution and the second distribution and uses the difference to make a determination of goodness of the deep learning model as applied to the biological assay.

IPC Classes  ?

• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

A system for determining a goodness of a deep learning model comprises a memory coupled with a processor. The processor accesses a first set of vectors representative of images of a biological assay. The vectors of the first set of vectors are outputs of a first deep learning model. The processor creates a first distribution of a first plurality of pairwise comparisons of vectors, of the first set of vectors, which were generated from image pairs with similar cell perturbations. The processor creates a second distribution of a second plurality of pairwise comparisons of vectors, of the first set of vectors, which were generated from image pairs with dissimilar cell perturbations. The processor determines a difference between the first distribution and the second distribution and uses the difference to make a determination of goodness of the deep learning model as applied to the biological assay.

IPC Classes  ?

• G16B 5/20 - Probabilistic models
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

A system for selecting CRISPR guides for knocking out one or more target genes in a target cell from a multiplicity of candidate guides comprises a memory and a processor. The processor determines whether the candidate guide meets a plurality of thresholds. The thresholds are associated with: a transcript support level; targeting a consensus sequence of a target gene; which exon of the target gene is targeted; targeting of a primary transcript, targeting of a common isoform; a precomputed prediction of editing outcomes; mapping to an expressed sequence; fraction of gene expression attributable to targeted transcripts; a common SNP overlap threshold; which exon of the target gene is targeted; overlap of a selected guide; predicted frameshift percentage; maximum and minimum GC content; off target score; where a coding sequence is targeted. In response to meeting the thresholds, the processor selects the candidate guide as a selected CRISPR guide.

IPC Classes  ?

• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• C12N 9/22 - Ribonucleases
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G16B 30/10 - Sequence alignment; Homology search

Abstract

The present disclosure provides CRISPR-Cas systems for the creating mutated genes within cells within wells of an addressable well plate.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/22 - Ribonucleases

Abstract

The present disclosure provides CRISPR-Cas systems for the creating mutated genes within cells within wells of an addressable well plate.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/22 - Ribonucleases
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The present disclosure provides CRISPC-Cas systems for the creating mutated genes within cells within wells of an addressable well plate.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/22 - Ribonucleases
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

Evaluating an effect of one or more perturbations on cells of a first cell type is described. One method includes obtaining a screen definition for a screen, where the screen includes a cell-based assay that is run on a temporarily contiguous basis using a plurality of multi-well plates. The method includes obtaining control vectors including measurements of corresponding features of cells in control wells. The method includes obtaining test vectors including measurements of corresponding features of cells in test wells. The method includes forming a variability model based on a variance across the of control vectors, and embedding test vectors onto the variability model, thereby obtaining a set of variability model values. The method includes using the set of variability model values to resolve an effect of at least one data perturbation in the plurality of data perturbations on the first cell type.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G16B 5/20 - Probabilistic models
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

In various embodiments, a molecule exploration application determines one or more potential drug candidates during a drug discovery process. The molecule exploration application generates derived molecule specifications based on a query molecule specification and edit heuristics. Subsequently, the molecule exploration application performs, via a mapping algorithm, one or more mapping operations on the derived molecule specifications to generate mapped molecule specifications. The molecule exploration application then performs one or more search operations on a mapped catalog of molecules based on the mapped molecule specifications to determine the one or more potential drug candidates. Advantageously, the molecule exploration application can be used to efficiently determine additional drug development candidates during a drug discovery process.

IPC Classes  ?

• G16C 20/70 - Machine learning, data mining or chemometrics
• G16C 20/00 - Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures

Abstract

In various embodiments, a molecule exploration application determines one or more potential drug candidates during a drug discovery process. The molecule exploration application generates derived molecule specifications based on a query molecule specification and edit heuristics. Subsequently, the molecule exploration application performs, via a mapping algorithm, one or more mapping operations on the derived molecule specifications to generate mapped molecule specifications. The molecule exploration application then performs one or more search operations on a mapped catalog of molecules based on the mapped molecule specifications to determine the one or more potential drug candidates. Advantageously, the molecule exploration application can be used to efficiently determine additional drug development candidates during a drug discovery process.

IPC Classes  ?

• G16C 20/50 - Molecular design, e.g. of drugs
• G16C 20/70 - Machine learning, data mining or chemometrics
• G16C 20/40 - Searching chemical structures or physicochemical data

Abstract

In various embodiments, a molecule exploration application determines one or more potential drug candidates during a drug discovery process. The molecule exploration application generates derived molecule specifications based on a query molecule specification and edit heuristics. Subsequently, the molecule exploration application performs, via a mapping algorithm, one or more mapping operations on the derived molecule specifications to generate mapped molecule specifications. The molecule exploration application then performs one or more search operations on a mapped catalog of molecules based on the mapped molecule specifications to determine the one or more potential drug candidates. Advantageously, the molecule exploration application can be used to efficiently determine additional drug development candidates during a drug discovery process.

IPC Classes  ?

• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)

Abstract

In various embodiments, an experiment analysis application detects executional artifacts in experiments involving microwell plates. The experiment analysis application computes one or more sets of spatial features based on one or more heat maps associated with a microwell plate. The experiment analysis application then aggregates the set(s) of spatial features to generate a feature vector. The experiment analysis application inputs the feature vector into a trained classifier. In response, the trained classifier generates a label indicating that the microwell plate is associated with a first executional artifact.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

Abstract

Methods and compositions are provided for treating lysosomal storage diseases and symptoms thereof. The methods include administering a PKC inhibitor, a GSK3β inhibitor, or an inhibitor of both.

IPC Classes  ?

• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4439 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61P 3/00 - Drugs for disorders of the metabolism

Abstract

In various embodiments, an experiment analysis application detects executional artifacts in experiments involving microwell plates. The experiment analysis application computes one or more sets of spatial features based on one or more heat maps associated with a microwell plate. The experiment analysis application then aggregates the set(s) of spatial features to generate a feature vector. The experiment analysis application inputs the feature vector into a trained classifier. In response, the trained classifier generates a label indicating that the microwell plate is associated with a first executional artifact.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06N 20/00 - Machine learning
• G06V 10/50 - Extraction of image or video features by summing image-intensity values; Projection analysis
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

In various embodiments, a training application trains a classifier to detect executional artifacts in experiments involving microwell plates. The training application computes spatial information based on a heat map associated with a microwell plate. The training application then computes a set of features based on the spatial information. Subsequently, the training application executes one or more machine learning operations based, at least in part, on the set of features to generate a trained classifier. The trained classifier classifies sets of features associated with different microwell plates with respect to labels associated with executional artifacts. Advantageously, the trained classier can be used to accurately and consistently detect executional artifacts across different experiments and over time.

IPC Classes  ?

• G06N 20/10 - Machine learning using kernel methods, e.g. support vector machines [SVM]
• G06K 9/62 - Methods or arrangements for recognition using electronic means
• G06N 3/08 - Learning methods
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

In various embodiments, an experiment analysis application detects executional artifacts in experiments involving microwell plates. The experiment analysis application computes one or more sets of spatial features based on one or more heat maps associated with a microwell plate. The experiment analysis application then aggregates the set(s) of spatial features to generate a feature vector. The experiment analysis application inputs the feature vector into a trained classifier. In response, the trained classifier generates a label indicating that the microwell plate is associated with a first executional artifact.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G06T 7/00 - Image analysis
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

Abstract

Method and apparatus for molecular scaffold hopping. Sending instructions, from an interface of a scheduler computer to a job runner computer, the instructions prepared by a processor of the scheduler computer, to perform separate computational tasks, wherein each of the separate computational tasks includes calculating chemical properties for a query molecule or a library of molecules. One or more of the separate computational tasks performed on the job runner computer are preemptible computing instances. Receiving status indicators, by the interface, the status indicators sent from the job runner computer, for each of the separate computational tasks, the indicators are: incomplete, completed or failed computing instances. Resending to the job runner computer by the interface, the instructions to the job runner computer corresponding to the separate computational tasks having the failed computing instance indicator to increase fault-tolerance against the separate computational tasks not attaining the completed computing instance indicator.

IPC Classes  ?

• G06F 17/30 - Information retrieval; Database structures therefor
• G06F 9/50 - Allocation of resources, e.g. of the central processing unit [CPU]

Abstract

In a method of molecular scaffold hopping an interface of a scheduler computer sends instructions, prepared by the scheduler computer, to a job runner computer to perform a plurality of separate computational tasks. Each of the separate computational tasks includes calculating one or more chemical properties for a query molecule or molecules in a library of molecules. One or more of the plurality of separate computational tasks performed on the job runner computer are preemptible computing instances. Status indicators sent from the job runner computer are received by the interface for each of the plurality of separate computational tasks. The indicators are one of: incomplete, completed, or failed computing instances. The interface resends the instructions to the job runner computer that correspond to the separate computational tasks having the failed computing instance indicator to increase fault-tolerance against the separate computational tasks not attaining the completed computing instance indicator.

IPC Classes  ?

• G06F 3/00 - Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
• G16C 20/40 - Searching chemical structures or physicochemical data
• G06F 11/07 - Responding to the occurrence of a fault, e.g. fault tolerance
• G06F 9/54 - Interprogram communication
• G06F 9/48 - Program initiating; Program switching, e.g. by interrupt

Abstract

The disclosure provides methods and systems for identifying a subset of compounds in a plurality of compounds. The identifying includes obtaining, for each compound, a vector including a set of elements, where each element includes a measurement of a different feature of an instance of a cell context upon exposure to the compound. The identifying includes performing the obtaining for a plurality of cell contexts, to obtain a plurality of vectors for each compound across different cell contexts. The identifying includes combining the vectors for each compound to form a combined vector for each compound, thereby forming a plurality of combined vectors representing different compounds. The identifying includes pruning the plurality of compounds to the subset of compounds based on a similarity between respective combined vectors in the plurality of combined vectors corresponding to compounds in the plurality of compounds.

IPC Classes  ?

• G16C 20/20 - Identification of molecular entities, parts thereof or of chemical compositions
• G06F 17/16 - Matrix or vector computation
• G16C 20/40 - Searching chemical structures or physicochemical data

Abstract

An acoustic liquid transfer system comprises: a processor; a source holding component configured to hold a source microplate; a destination holding component configured to hold a destination microplate; an acoustic transducer configured to cause liquid to transfer between the source and destination microplates; and a controller configured to direct movements, according to an ordered picklist, of one or more of the: source holding component, destination holding component, and acoustic transducer. The processor is configured to access an initial picklist of a plurality of source/destination pairs; obtain a current source/destination pair on the ordered picklist being created; calculate a plurality of movement metrics between the current source/destination pair and at least some of the plurality of source/destination pairs on the initial picklist but not yet on the ordered picklist; select a next source/destination pair with reference to the movement metrics; and add the next source/destination pair to the ordered picklist.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• H04R 1/28 - Transducer mountings or enclosures designed for specific frequency response; Transducer enclosures modified by provision of mechanical or acoustic impedances, e.g. resonator, damping means
• H04R 1/32 - Arrangements for obtaining desired frequency or directional characteristics for obtaining desired directional characteristic only
• H04R 1/42 - Combinations of transducers with fluid-pressure or other non-electrical amplifying means
• H04R 7/08 - Plane diaphragms comprising a plurality of sections or layers comprising superposed layers separated by air or other fluid
• H04R 17/02 - Microphones
• G05B 19/18 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form

Abstract

A method for preparing a card containing at least one sequestered compound is provided. The method includes preparing a first waxy phase, preparing a first volatile phase comprising a first sequestered compound, creating a first emulsion from the first waxy phase and the first volatile phase, depositing the first emulsion on the card, and cooling the first emulsion.

IPC Classes  ?

• A61K 9/107 - Emulsions
• A61K 9/00 - Medicinal preparations characterised by special physical form
• B05D 7/00 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials

Goods & Services

Downloadable or recorded computer software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds. Scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (saas) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds; pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; drug use discovery services.

Goods & Services

(1) Computer software to diagnose medical conditions, namely, blood disorders, rare genetic disorders, oncological diseases and disorders, and infectious diseases, to prescribe medical treatment for blood disorders, rare genetic disorders, oncological diseases and disorders, and infectious diseases and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze patient medical information, and to develop pharmaceutical products and chemical compounds for diagnosing and treating blood disorders, rare genetic disorders, and infectious diseases. (1) Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; drug use discovery services; scientific and technological services namely, medical research laboratory services, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, namely, blood disorders, rare genetic disorders, oncological diseases and disorders, and infectious diseases, to prescribe medical treatment for blood disorders, rare genetic disorders, oncological diseases and disorders, and infectious diseases and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze patient medical information, and to develop pharmaceutical products and chemical compounds for diagnosing and treating blood disorders, rare genetic disorders, and infectious diseases.

Goods & Services

(1) Computer software to diagnose medical conditions, namely, blood disorders, rare genetic disorders, oncological diseases and disorders, and infectious diseases, to prescribe medical treatment for blood disorders, rare genetic disorders, oncological diseases and disorders, and infectious diseases and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze patient medical information, and to develop pharmaceutical products and chemical compounds for diagnosing and treating blood disorders, rare genetic disorders, and infectious diseases. (1) Scientific and technological services, namely, medical research laboratory services, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, namely, blood disorders, rare genetic disorders, oncological diseases and disorders, and infectious diseases, to prescribe medical treatment for blood disorders, rare genetic disorders, oncological diseases and disorders, and infectious diseases and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze patient medical information, and to develop pharmaceutical products and chemical compounds for diagnosing and treating blood disorders, rare genetic disorders, and infectious diseases; pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; drug use discovery services.

Goods & Services

Pharmaceutical research and development services; scientific research and development of pharmaceutical preparations; pharmaceutical research services, namely, developing new uses for pharmaceutical compounds through the use of computer models, animal models, and controlled environments; contract research services in support of scientific research and development of pharmaceutical preparations; technical consultancy and services in relation to technical research in the field of pharmaceuticals; consultancy in relation to scientific research in the field of pharmaceuticals; providing medical research and scientific research information in the field of medicine and pharmaceuticals; drug discovery services; drug use discovery services; scientific and technological services, namely, medical laboratories, scientific research and design for others in the field of pharmaceuticals, conducting and evaluating clinical trials; software as a service (SaaS) featuring software to diagnose medical conditions, to prescribe medical treatment and prescriptions, to design clinical trials and forecast clinical trial results, to search for clinical trial patients, to analyze medical images, to analyze data, and to develop pharmaceutical products and chemical compounds

Abstract

A method of determining a cognitive state of an experimental animal in a cage is provided. The cage includes one or more walls that enclose a living space for containing the experimental animal, and a heating structure. The method includes installing a card with at least a first type of sequestered olfactory compound, directing the heating structure to selectively heat the card to release the first type of sequestered first type of olfactory compound to subject the experimental animal to a novel olfactory experience, creating a first assessment of a behavior of the laboratory animal, subjecting the experimental animal to experimental procedures and/or waiting a selected amount of time, directing the heating structure to selectively heat the card to release more of the first type of sequestered olfactory compound, creating a second assessment of a behavior of the experimental animal, and evaluating the first and second assessments to determine the cognitive state of the experimental animal.

IPC Classes  ?

• A01K 1/03 - Housing for domestic or laboratory animals
• A01K 1/00 - Housing animals; Equipment therefor
• A01K 29/00 - Other apparatus for animal husbandry
• H04N 7/18 - Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast
• G06T 7/00 - Image analysis
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

Abstract

Methods and systems are provided for determining whether a first cellular perturbation interacts with a second cellular perturbation in one of a specific cellular context and a background, in a cell based assay. Data points for one or more baseline state, perturbation state, compound state, and combination state are obtained, where the data points each include data for a plurality of cellular characteristics acquired across instances of the respective cellular state. A dimension reduction model is applied the data points to achieve a plurality of feature values from each of the data points. It is then determined whether the first cellular perturbation interacts with the second cellular perturbation in one of a specific cellular context and a background by using the features values achieved from the data points to resolve whether the combination of the gene and the compound has a threshold interaction effect on one or more cellular characteristics.

IPC Classes  ?

• G06F 19/12 - for modelling or simulation in systems biology, e.g. probabilistic or dynamic models, gene-regulatory networks, protein interaction networks or metabolic networks

Abstract

Methods and systems are provided for determining whether a first cellular perturbation interacts with a second cellular perturbation in one of a specific cellular context and a background, in a cell based assay. Data points for one or more baseline state, perturbation state, compound state, and combination state are obtained, where the data points each include data for a plurality of cellular characteristics acquired across instances of the respective cellular state. A dimension reduction model is applied the data points to achieve a plurality of feature values from each of the data points. It is then determined whether the first cellular perturbation interacts with the second cellular perturbation in one of a specific cellular context and a background by using the features values achieved from the data points to resolve whether the combination of the gene and the compound has a threshold interaction effect on one or more cellular characteristics.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G16B 25/00 - ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
• G06N 3/02 - Neural networks

Abstract

An electronic monitor can monitor experimental animals in a cage. The cage has one or more walls that enclose a living space for the experimental animals. The electronic monitor is coupled to the cage. The electronic monitor may include a housing adapted to be mechanically coupled to the cage in a predefined position relative to the cage. A substantially sterile barrier is provided between the living space and the external environment in this coupled state. The walls of the cage may include a signal-interface section. An electromagnetic detector may be coupled to the housing to have a line-of-sight through the signal-interface section and into the living space of the cage. The electromagnetic detector is adapted to detect electromagnetic radiation that is transmitted through the signal-interface section. A controller processes a signal received from the electromagnetic detector to determine a status of the experimental animals or the living space.

IPC Classes  ?

• A01K 1/03 - Housing for domestic or laboratory animals

Abstract

Systems and methods for determining whether a set of test perturbations discriminates over a null distribution for an on target effect against a first component of an entity are disclosed. The perturbations are perturbations of the first component and the entity comprises a plurality of components. For each perturbation in the set, a corresponding vector comprising a plurality of elements, is obtained. Each element comprises a distribution metric of measurements of a feature across instances of the entity upon exposure to the respective perturbation or (ii) a distribution metric of a respective dimension reduction component computed using the measurement of the plurality of features across instances of the entity upon the perturbation exposure. A composite metric is computed, using the vectors, and compared to a null distribution. When the composite metric is differentiated from the null distribution, the set of perturbations is deemed to discriminate the on target effect against the first component over the null distribution.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• G01N 21/64 - Fluorescence; Phosphorescence
• G16C 20/50 - Molecular design, e.g. of drugs
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

Methods and systems for evaluating a query perturbation, in a cell based assay representing a test state, are provided. Control data points having dimensions representing measurements of different features across control cell aliquots are obtained. Test data points having dimensions representing measurements of different features across test cell aliquots are obtained. A composite test vector is computed between measures of central tendency across the control data points and measures of central tendency across the test data points. Query perturbation data points having dimensions representing measurements of different features across perturbation cell aliquots are obtained. A composite query perturbation vector is computed between measures of central tendency across the control data points and measures of central tendency across the plurality of query perturbation data points.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• G01N 21/64 - Fluorescence; Phosphorescence
• G16C 20/50 - Molecular design, e.g. of drugs

Abstract

Methods and systems for evaluating a query perturbation, in a cell based assay representing a test state, are provided. Control data points having dimensions representing measurements of different features across control cell aliquots are obtained. Test data points having dimensions representing measurements of different features across test cell aliquots are obtained. A composite test vector is computed between measures of central tendency across the control data points and measures of central tendency across the test data points. Query perturbation data points having dimensions representing measurements of different features across perturbation cell aliquots are obtained. A composite query perturbation vector is computed between measures of central tendency across the control data points and measures of central tendency across the plurality of query perturbation data points.

IPC Classes  ?

• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis