The present invention is directed to a sealant patch for use on or over sensitive tissue, comprising: a flat, flexible, bioresorbable substrate coated by a moisture-activated adhesive on one side thereof, wherein said adhesive is at least partially inactivated in a first portion of said patch, but remains active in peripheral areas surrounding the first portion. The adherence of the first portion to the tissue is weaker versus adherence in the peripheral areas. The adhesive in the first portion is fully or partially inactivated or pre-reacted prior to application of the sealant patch to the tissue.
A61F 15/00 - Auxiliary appliances for wound dressingsDispensing containers for dressings or bandages
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
The present invention is directed to a sealant patch for use on or over sensitive tissue, comprising: a flat, flexible, bioresorbable substrate coated by a moisture-activated adhesive on one side thereof, wherein said adhesive is at least partially inactivated in a first portion of said patch, but remains active in peripheral areas surrounding the first portion. The adherence of the first portion to the tissue is weaker versus adherence in the peripheral areas. The adhesive in the first portion is fully or partially inactivated or pre-reacted prior to application of the sealant patch to the tissue.
An apparatus for use with an instrument includes a hub, a shaft assembly, and a navigation sensor. The hub is configured to engage a portion of the instrument, in only a predetermined angular orientation with respect to an axis of the instrument. The shaft assembly extends from the hub and defines a hollow interior and an open distal end. The hollow interior is configured to receive a tubular portion of the instrument. The navigation sensor can be disposed proximate the open distal end of the shaft assembly. The navigation sensor can be configured to generate a signal indicating a portion of at least a portion of the shaft assembly in three-dimensional space.
An apparatus includes a body, a rotary member, a navigation sensor, and an alignment system. The rotary member is sized and configured to fit in an anatomical passageway of a patient; and is configured to rotate relative to the body about a rotational axis. The navigation sensor is configured to generate first signals indicative of a position of the body in three-dimensional space. The alignment system includes a magnet and a Hall effect sensor. The magnet is fixedly secured to the rotary member; and is configured to generate a magnetic field. The Hall effect sensor is fixedly secured to the body and is configured to detect a magnitude of the magnetic field and to generate second signals indicative of an angular position of the rotary member relative to the body about the rotational axis.
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
An apparatus for use with an instrument includes a hub, a shaft assembly, and a navigation sensor. The hub is configured to engage a portion of the instrument, in only a predetermined angular orientation with respect to an axis of the instrument. The shaft assembly extends from the hub and defines a hollow interior and an open distal end. The hollow interior is configured to receive a tubular portion of the instrument. The navigation sensor can be disposed proximate the open distal end of the shaft assembly. The navigation sensor can be configured to generate a signal indicating a portion of at least a portion of the shaft assembly in three-dimensional space.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
6.
MEDICAL INSTRUMENT WITH INTEGRAL POSITION SENSOR AND HALL EFFECT SENSOR
An apparatus includes a body, a rotary member, a navigation sensor, and an alignment system. The rotary member is sized and configured to fit in an anatomical passageway of a patient; and is configured to rotate relative to the body about a rotational axis. The navigation sensor is configured to generate first signals indicative of a position of the body in three-dimensional space. The alignment system includes a magnet and a Hall effect sensor. The magnet is fixedly secured to the rotary member; and is configured to generate a magnetic field. The Hall effect sensor is fixedly secured to the body and is configured to detect a magnitude of the magnetic field and to generate second signals indicative of an angular position of the rotary member relative to the body about the rotational axis.
A dilation catheter apparatus includes a shaft, an expandable dilation member, and a bulbous tip. The shaft has a first outer cross-sectional dimension. The dilation member is positioned proximal to the distal end of the shaft. The dilation member is operable to transition between a non-expanded configuration and an expanded configuration. The dilation member is sized to pass through a passageway associated with drainage of a paranasal sinus or a Eustachian tube when the dilation member is in the non-expanded configuration. The bulbous tip is positioned at the distal end of the shaft. The bulbous tip is distal to the dilation member. The bulbous tip has a second outer cross-sectional dimension. The second outer cross-sectional dimension is larger than the first outer cross-sectional dimension. The bulbous tip is removably secured to the distal end of the shaft.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
The present invention is directed to methods for processing absorbable, slow-to-crystallize poly(p-dioxanone) ground resin and its fines utilizing a twin-screw extruder apparatus to produce uniform pellets. Advantageously, the ground resin materials resulting from solid-state polymerization do not undergo processing, such as sieving, to remove fines from the feedstock for an extrusion and pelletizing system that has been configured with an inverted temperature profile along the extrusion barrel. The resulting PDS pellets have improved resin uniformity and greater polymer yield for improved operational efficiencies and production of extruded filaments.
The present invention is directed to hemostatic and/or tissue adhesive formulations comprising crosslinked polysaccharide particles that have been oxidized to generate aldehyde- and carboxylic functional moieties therein, and wherein said formulations further contain a buffer that maintains a slightly alkaline environment. These formulations can be applied onto tissue in the form of a powder, paste or patch to effect hemostasis or sealing.
The present invention is directed to hemostatic and/or tissue adhesive formulations comprising crosslinked polysaccharide particles that have been oxidized to generate aldehyde- and carboxylic functional moieties therein, and wherein said formulations further contain a buffer that maintains a slightly alkaline environment. These formulations can be applied onto tissue in the form of a powder, paste or patch to effect hemostasis or sealing.
An apparatus includes a base, an actuator, and a clamp member. The actuator is pivotably coupled with the base. The clamp member is operable to selectively clamp a malleable guide rail relative to the base. The guide rail is configured to fit in an anatomical passageway in a head of a patient. The actuator is operable to pivot relative to the base to thereby bend the guide rail while the guide rail is clamped by the clamp member.
An apparatus includes a base, an actuator, and a clamp member. The actuator is pivotably coupled with the base. The clamp member is operable to selectively clamp a malleable guide rail relative to the base. The guide rail is configured to fit in an anatomical passageway in a head of a patient. The actuator is operable to pivot relative to the base to thereby bend the guide rail while the guide rail is clamped by the clamp member.
B21D 7/024 - Bending rods, profiles, or tubes over a stationary forming memberBending rods, profiles, or tubes by use of a swinging forming member or abutment by a swinging forming member
A virtual endoscopic view shows a surgical area and surrounding anatomy and may also show a position of a surgical instrument in use during a surgical procedure, allowing a surgeon to virtually view the surgical area when direct viewing or actual endoscopic views are incomplete, obstructed, or otherwise unavailable or undesirable. In order to render the endoscopic view, an IGS navigation system may be configured with an observer point and an observer orientation within 3-D space based upon user inputs. A user interface for defining these points allows a user to view a virtual endoscopic preview in real-time while providing inputs, thus improving the likelihood that the resulting virtual endoscopic view is as desired by the user; and reducing time spent redefining and reconfiguring the virtual endoscopic view. The virtual endoscopic preview may provide combinations of static and dynamic images to illustrate the spatial relationship of the provided inputs.
G06F 3/04815 - Interaction with a metaphor-based environment or interaction object displayed as three-dimensional, e.g. changing the user viewpoint with respect to the environment or object
A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G06F 3/04842 - Selection of displayed objects or displayed text elements
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
A catheter system includes a balloon dilation catheter having a proximal end portion and a distal end portion. The balloon dilation catheter includes a dilation balloon lumen that is configured to couple with a first fluid supply. An expandable dilation balloon is fluidly connected to the dilation balloon lumen. The expandable dilation balloon is configured to transition between an inflated state and a non-inflated state. An expandable stop element is configured to selectively transition among a range of expanded states including a non-expanded state, a first expanded state, and a second expanded state. The expandable stop element defines an outer diameter such that the outer diameter defines a minimum diameter when the expandable stop element is in the non-expanded state and a maximum diameter when the expandable stop element is in the second expanded state.
Medical and surgical devices, namely, apparatus for treatment of diseases and conditions of, or involving, the nose and paranasal sinuses; balloon dilation catheters for treatment of sinus; surgical devices, namely, a sinus dilation system
16.
ENDOSCOPE CLEANING SHEATH WITH INTEGRAL POSITION SENSOR
An apparatus for use with an endoscope or other ENT instrument includes a hub, a shaft assembly, and one or more navigation sensors. The hub being configured to receive a portion of the endoscope and including a fluid port. The shaft assembly extends from the hub and defines a hollow interior. The hollow interior is configured to receive a tubular portion of the endoscope and communicate fluid within the shaft assembly to an open distal end of the shaft assembly. At least one of the one or more navigation sensors is disposed proximate the distal end of the shaft assembly. The one or more navigation sensors are configured to communicate with an IGS navigation system to locate at least a portion of the shaft assembly in three dimensional space.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/12 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with cooling or rinsing arrangements
17.
ENDOSCOPE CLEANING SHEATH WITH INTEGRAL POSITION SENSOR
An apparatus for use with an endoscope or other ENT instrument includes a hub, a shaft assembly, and one or more navigation sensors. The hub being configured to receive a portion of the endoscope and including a fluid port. The shaft assembly extends from the hub and defines a hollow interior. The hollow interior is configured to receive a tubular portion of the endoscope and communicate fluid within the shaft assembly to an open distal end of the shaft assembly. At least one of the one or more navigation sensors is disposed proximate the distal end of the shaft assembly. The one or more navigation sensors are configured to communicate with an IGS navigation system to locate at least a portion of the shaft assembly in three dimensional space.
The present invention is directed to an absorbable hemostatic nonwoven patch that utilizes a biocompatible substrate comprised of melt-blown microfibers as webbed sheets that are layered and bonded/entangled in descending density and ascending porosity; with the substrate having a high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ability for laparoscopic use or trocar deployment, ultimately for functional use as a highly effective hemostat in addressing problematic bleeding during both open and minimally invasive surgical procedures.
A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
19.
BALLOON DILATION INSTRUMENT WITH TRANSLATING GUIDE TIP ELEMENT
A dilation catheter (160) is slidably disposed relative to a first guide (170). A second guide (180) is slidably disposed relative to the first guide and relative to the dilation catheter. The second guide includes an indicator element (186) indicating a position of the distal end of the second guide in three-dimensional space. The second guide positions the indicator element at the distal end of the first guide and remains longitudinally stationary as the dilation catheter translates distally from a proximal position to an intermediate longitudinal position. The second guide translates concomitantly with the dilation catheter as the dilation catheter translates distally from the intermediate longitudinal position to a distal position. The indicator element is positioned with the distal end of the dilation catheter as the dilation catheter translates distally from the intermediate longitudinal position to a distal position.
An apparatus (10) includes a body assembly (20), a guide rail (50), a dilation catheter (40), and a guide rail actuation assembly. The guide rail extends distally from the body assembly and has a malleable distal portion with a distal end (52). The dilation catheter is slidably disposed relative to the guide rail. The dilation catheter includes an expandable element (44) configured to dilate a passageway within a head of a patient. The a guide rail actuation assembly is operable to drive longitudinal movement of the guide rail relative to the body assembly between a distal position and a proximal position. The guide rail actuation assembly is configured to maintain the guide rail at a selected one of the distal position or the proximal position.
An apparatus (10) includes a handle (20), a guide member (50) extending distally from the handle, and a dilation catheter (40) slidably disposed relative to the guide member. The dilation catheter is operable to translate relative to the handle along a longitudinal range of motion from a proximal-most position to a distal-most position. The dilation catheter includes an expandable element (44) configured to dilate a passageway within the head of a patient and a distal end. The dilation catheter actuator includes a rotary member (60) operable to rotate relative to the handle to thereby drive translation of the dilation catheter along the longitudinal range of motion.
An apparatus includes a body assembly, a guide rail, a dilation catheter, and a guide rail actuation assembly. The guide rail extends distally from the body assembly and has a malleable distal portion with a distal end. The dilation catheter is slidably disposed relative to the guide rail. The dilation catheter includes an expandable element configured to dilate a passageway within a head of a patient. The a guide rail actuation assembly is operable to drive longitudinal movement of the guide rail relative to the body assembly between a distal position and a proximal position. The guide rail actuation assembly is configured to maintain the guide rail at a selected one of the distal position or the proximal position.
A dilation catheter is slidably disposed relative to a first guide. A second guide is slidably disposed relative to the first guide and relative to the dilation catheter. The second guide includes an indicator element indicating a position of the distal end of the second guide in three-dimensional space. The second guide positions the indicator element at the distal end of the first guide and remains longitudinally stationary as the dilation catheter translates distally from a proximal position to an intermediate longitudinal position. The second guide translates concomitantly with the dilation catheter as the dilation catheter translates distally from the intermediate longitudinal position to a distal position. The indicator element is positioned with the distal end of the dilation catheter as the dilation catheter translates distally from the intermediate longitudinal position to a distal position.
An apparatus includes a handle, a guide member extending distally from the handle, and a dilation catheter slidably disposed relative to the guide member. The dilation catheter is operable to translate relative to the handle along a longitudinal range of motion from a proximal-most position to a distal-most position. The dilation catheter includes an expandable element configured to dilate a passageway within the head of a patient and a distal end. The dilation catheter actuator includes a rotary member operable to rotate relative to the handle to thereby drive translation of the dilation catheter along the longitudinal range of motion.
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded software for placing virtual cameras in a surgical field; recorded software for placing virtual cameras as a feature of an ear, nose, and throat navigation system; recorded software that simulates a physical camera and allows the user to send video and audio to a surgical navigation system
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded software for combining imaging scans, such as CT scans and MR scans, for use in a surgical navigation system; recorded software for processing imaging data as a feature of an ear, nose, and throat navigation system
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded software for applying segmentation to anatomical structures in a surgical navigation system; recorded software for applying segmentation to anatomical structures as a feature of an ear, nose, and throat navigation system
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded software for loading imaging scans from the network to a surgical navigation system; recorded software for loading imaging scans from the network as a feature of an ear, nose, and throat navigation system
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded software for calculating and presenting the shortest, valid path between two points specified by the physician in a surgical navigation system; recorded software for determining a path between pre-determined points as a feature of an ear, nose, and throat navigation
31.
COCHLEAR IMPLANT WITH ONE OR MORE NAVIGATION SENSORS
An apparatus includes an elongate body. A distal portion of the elongate body is configured to fit in a cochlea of a patient. A plurality of stimulation elements are positioned along the distal portion of the elongate body. The stimulation elements are operable to stimulate auditory nerves in the cochlea of the patient. One or more position sensors are positioned along the elongate body. Each position sensor of the one or more position sensors is configured to generate a signal indicating a position of the position sensor in three-dimensional space.
A first registration point is captured at a first location on a first lateral side of the head of a patient, based on a signal from a position sensor of a registration probe positioned at the first location. The signal from the position sensor indicates a real-time position of the position sensor in three- dimensional space. A second registration point is captured at a second location on the first lateral side of the head of the patient, based on a signal from the position sensor of the registration probe positioned at the second location. The patient is lying on the second lateral side of their head during the acts of capturing the registration points. A real-time position of the patient is registered with an image guided surgery system, based on at least the first and second captured registration points.
An apparatus includes a body and the first position sensor. The body defines a bore sized to receive a portion of a medical instrument having a rotary member. The rotary member is configured to generate interference in an electromagnetic field while rotating about a longitudinal axis. The body is configured to be fixedly secured to the medical instrument while allowing rotation of the rotary member about the longitudinal axis. The first position sensor is supported by the body and is configured to generate a signal indicating a position of the first position sensor in three- dimensional space. The first position sensor is oriented to offset the interference generated by the rotary member.
An apparatus such as a suction instrument includes a position sensor proximate to a distal tip of a malleable shaft. A sensor wire couples the position sensor to a processor of an image guided surgery system such that signals generated by the position sensor can be interpreted to determine the position of the surgical instrument. The malleable shaft includes a malleable outer shaft and a flexible inner tube. The flexible inner tube includes a primary lumen that can provide suction, fluid, or various deployable surgical tools, and an inner lumen that holds the sensor wire. Protected within the inner lumen, the sensor wire runs the length of the shaft and exits the inner lumen and passes through a slot in the outer shaft to reach the position sensor. A heat shrink cover wraps the distal tip, sealing the components together and providing an opening suitable for suction.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
35.
PATIENT TRACKING DEVICE FOR USE WITH MEDICAL INSTRUMENT NAVIGATION SYSTEM
An apparatus includes a tray, a deformable material, and a position sensor. The tray is configured to correspond to at least a portion of an alveolar ridge of a patient. The deformable material is configured to receive dentition of the alveolar ridge of the patient and thereby secure the tray relative to the alveolar ridge of the patient. The position sensor is fixed relative to the tray and is configured to generate a signal indicating a real-time position of the position sensor within three- dimensional space. Another apparatus includes a body, a position sensor, and a suction conduit. The body defines a cavity and is configured to fit in a mouth of a patient. The suction conduit is in fluid communication with the cavity and is configured to apply suction to the cavity to thereby secure the body to a cheek wall in the mouth of the patient.
An apparatus includes an elongate body. A distal portion of the elongate body is configured to fit in a cochlea of a patient. A plurality of stimulation elements are positioned along the distal portion of the elongate body. The stimulation elements are operable to stimulate auditory nerves in the cochlea of the patient. One or more position sensors are positioned along the elongate body. Each position sensor of the one or more position sensors is configured to generate a signal indicating a position of the position sensor in three-dimensional space.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
37.
METHOD OF REGISTERING A PATIENT WITH MEDICAL INSTRUMENT NAVIGATION SYSTEM
A first registration point is captured at a first location on a first lateral side of the head of a patient, based on a signal from a position sensor of a registration probe positioned at the first location. The signal from the position sensor indicates a real-time position of the position sensor in three-dimensional space. A second registration point is captured at a second location on the first lateral side of the head of the patient, based on a signal from the position sensor of the registration probe positioned at the second location. The patient is lying on the second lateral side of their head during the acts of capturing the registration points. A real-time position of the patient is registered with an image guided surgery system, based on at least the first and second captured registration points.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
38.
MEDICAL INSTRUMENT WITH ROTARY END EFFECTOR, POSITION SENSOR, AND ELECTROMAGNETIC INTERFERENCE REDUCTION
An apparatus includes a body and the first position sensor. The body defines a bore sized to receive a portion of a medical instrument having a rotary member. The rotary member is configured to generate interference in an electromagnetic field while rotating about a longitudinal axis. The body is configured to be fixedly secured to the medical instrument while allowing rotation of the rotary member about the longitudinal axis. The first position sensor is supported by the body and is configured to generate a signal indicating a position of the first position sensor in three-dimensional space. The first position sensor is oriented to offset the interference generated by the rotary member.
An apparatus includes an elongate shaft and a position sensor. The elongate shaft defines a longitudinal axis. The elongate shaft includes a distal end, an opening, and a lumen. The position sensor is laterally offset from the longitudinal axis. The first position sensor is fixedly secured relative to the elongate shaft at a known distance from the opening. The first position sensor is configured to generate signals indicating a position of the elongate shaft in three-dimensional space.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
40.
MEDICAL INSTRUMENT POSITION SENSOR SLEEVE WITH INTEGRAL HEATING ELEMENT
An apparatus for use with an ENT instrument includes a shaft, a heat shrink material, and a heating element. The shaft defines a hollow interior. The hollow interior is configured to receive a tubular portion of the ENT instrument. The heat shrink material is integrated into a portion of the shaft. The heating element is fixedly secured to the shaft or the heat shrink material. The heating element is configured to heat a portion of the heat shrink material to reduce a diameter of a portion of the shaft at a predetermined position along the length of the shaft.
A61B 17/24 - Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or noseTongue scrapers
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
41.
MEDICAL INSTRUMENT POSITION SENSOR SLEEVE WITH INTEGRAL HEATING ELEMENT
An apparatus for use with an ENT instrument includes a shaft, a heat shrink material, and a heating element. The shaft defines a hollow interior. The hollow interior is configured to receive a tubular portion of the ENT instrument. The heat shrink material is integrated into a portion of the shaft. The heating element is fixedly secured to the shaft or the heat shrink material. The heating element is configured to heat a portion of the heat shrink material to reduce a diameter of a portion of the shaft at a predetermined position along the length of the shaft.
An apparatus includes a tray, a deformable material, and a position sensor. The tray is configured to correspond to at least a portion of an alveolar ridge of a patient. The deformable material is configured to receive dentition of the alveolar ridge of the patient and thereby secure the tray relative to the alveolar ridge of the patient. The position sensor is fixed relative to the tray and is configured to generate a signal indicating a real-time position of the position sensor within three-dimensional space. Another apparatus includes a body, a position sensor, and a suction conduit. The body defines a cavity and is configured to fit in a mouth of a patient. The suction conduit is in fluid communication with the cavity and is configured to apply suction to the cavity to thereby secure the body to a cheek wall in the mouth of the patient.
A combined powder and liquid delivery device includes a housing having a powder chamber and a liquid chamber. The device includes an applicator tip having a powder delivery channel extending between a proximal end and a distal end of the applicator tip that is in fluid communication with the powder chamber, and a liquid delivery channel that extends from the proximal to the distal end of the applicator tip that is in fluid communication with the liquid chamber. The delivery device includes a powder inlet port in fluid communication with the powder chamber, and a liquid inlet port in fluid communication with the liquid chamber. A powder delivery system is in fluid communication with the powder inlet port, the powder chamber, and the powder delivery channel. A liquid delivery system is in fluid communication with the liquid inlet port, the liquid chamber, and the liquid delivery channel.
A medical procedure navigation system includes processing circuitry configured to obtain, from an electronic storage device, data associated with a medical procedure instrument, the electronic storage device being housed within the medical procedure instrument; obtain at least one preoperative patient image; track, using one or more tracking devices, a real-time location of the medical procedure instrument and an imaging instrument; obtain, from the imaging instrument, at least one patient image; determine, based on the data associated with the medical procedure instrument, at least one feature of the medical procedure instrument; identify, based on the real-time location of the medical procedure instrument and the imaging instrument and the at least one feature, a localized view of the at least one preoperative patient image; and superimpose and display, on a display device, a localized view of the at least one preoperative patient image over the at least one patient image.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/018 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor characterised by internal passages or accessories therefor for receiving instruments
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
45.
HEMOSTATIC SEALANT POWDER FOR SEALING LEAKS IN TISSUES
Disclosed herein are powdered compositions comprised of fibrinogen, thrombin, glycerol-water solution, and optionally oxidized cellulose (OC), wherein the glycerol is present at a concentration ranging from about 0.7% to about 6%, by weight; and wherein the OC is present at a concentration below about 9%, by weight, or is absent. Methods of making the compositions, and uses of the compositions in methods for treating a bleeding tissue, and for sealing leaks in tissues are further disclosed.
A healthcare system accommodates spasmodic clinical workflows for populating a records database associated with a surgical platform or other digital healthcare platform. An interoperability engine receives data streams including events from various electronic health records systems that provide data events according to varying format, order, and timing dependent on their corresponding clinical workflows. The interoperability engine maps indeterminate events to expected events associated with a clinical workflow based on a clinical workflow management file, an industry standard model, a general parsing model, or a combination thereof. The interoperability engine may furthermore detect non-compliance of received events and may generate feedback indicative of a compliance assessment.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A guide sheath includes ports at a handle portion through which flexible endoscopic tools may be advanced until they emerge from corresponding ports at a distal tip of the guide sheath. The guide sheath includes a position sensor at its distal tip that is compatible with an image guided surgery (IGS) system, such that a virtual view of the distal tip's position relative to a surgical site may be presented by the IGS system. The virtual view may assist a surgeon in precisely positioning the distal tip at the surgical site, and then one or more flexible endoscopic tools may be advanced the length of the guide sheath for use at the surgical site. The guide sheath may also include an articulating portion at the distal tip that may be deflected in one or more directions in order to provide additional control over placement within the surgical site.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/015 - Control of fluid supply or evacuation
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/24 - Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or noseTongue scrapers
A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
A method includes inserting a dilation catheter into a nostril of a patient and positioning a first dilator of the dilation catheter between a turbinate of the patient and an adjacent lateral nasal wall of the patient. The method also includes expanding the first dilator, thereby applying pressure to the turbinate of the patient, and removing the dilation catheter from the nostril of the patient.
A method includes inserting a variable distance electrode assembly within a patient. A first electrode of the variable distance electrode assembly is placed adjacent to a targeted tissue area. A second electrode of the variable distance electrode assembly is placed adjacent to the targeted tissue area such that the first electrode and the second electrode are spaced from each other to define a first distance. The first and second electrodes are activated to apply electrical energy to the targeted tissue area. The first electrode is translated relative to the second electrode to define a second distance between each other while the first electrode and the second electrode continue to apply electrical energy to the targeted tissue area.
A method includes inserting a variable distance electrode assembly within a patient. A first electrode of the variable distance electrode assembly is placed adjacent to a targeted tissue area. A second electrode of the variable distance electrode assembly is placed adjacent to the targeted tissue area such that the first electrode and the second electrode are spaced from each other to define a first distance. The first and second electrodes are activated to apply electrical energy to the targeted tissue area. The first electrode is translated relative to the second electrode to define a second distance between each other while the first electrode and the second electrode continue to apply electrical energy to the targeted tissue area.
Disclosed is a sealant, and techniques for making and using the sealant. The sealant may include three components that, when combined, produce the sealant: an electrophilic component, a nucleophilic component, and a doping component. The electrophilic component may include a first electrophilic material having a first functionality of a first reactive group. The nucleophilic component may include a first nucleophilic material having a second functionality of a second reactive group. The doping component may include a second electrophilic material having a third functionality of the first reactive group greater than the first functionality and/or a second nucleophilic material having a fourth functionality of the second reactive group greater than the second functionality. The doping component may be present in an amount sufficient to provide a 2-20% molar contribution of the first reactive group and/or the second reactive group in the sealant.
Disclosed is a sealant, and techniques for making and using the sealant. The sealant may include three components that, when combined, produce the sealant: an electrophilic component, a nucleophilic component, and a doping component. The electrophilic component may include a first electrophilic material having a first functionality of a first reactive group. The nucleophilic component may include a first nucleophilic material having a second functionality of a second reactive group. The doping component may include a second electrophilic material having a third functionality of the first reactive group greater than the first functionality and/or a second nucleophilic material having a fourth functionality of the second reactive group greater than the second functionality. The doping component may be present in an amount sufficient to provide a 2-20% molar contribution of the first reactive group and/or the second reactive group in the sealant.
An apparatus includes a body and a shaft assembly extending distally from the body. The shaft assembly includes a malleable distal portion and an enlarged tip positioned at a distal end of the malleable distal portion. The shaft assembly further includes a position sensor positioned within the enlarged tip. The position sensor is configured to generate a signal indicating a position of the enlarged tip in three-dimensional space. The shaft assembly further includes an illuminating element positioned within the enlarged tip. The illuminating element is configured to emit light. The shaft assembly further includes an inflatable balloon positioned proximal to the enlarged tip. The inflatable balloon is configured to dilate a passageway in an ear, nose, or throat of a patient.
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 1/233 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the nose, i.e. nasoscopes
A61B 17/00 - Surgical instruments, devices or methods
The present invention relates to devices capable of a) measuring a temperature at or near the device (e.g., a tissue region in contact with the device), and b) regulating the temperature (e.g., increasing, maintaining, or reducing) at or near the device, and related systems and methods.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
56.
TEMPERATURE REGULATING DEVICES AND RELATED SYSTEMS AND METHODS
The present invention relates to devices capable of a) measuring a temperature at or near the device (e.g., a tissue region in contact with the device), and b) regulating the temperature (e.g., increasing, maintaining, or reducing) at or near the device, and related systems and methods.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
Methods and systems for using a biocompatible and flexible hemostatic sheet comprising a fibrous carrier structure, and reactive electrophilic groups capable of reacting with amine groups in tissue and blood, the hemostatic sheet delivered through a trocar for restoring hemostasis to a tissue at a bleeding site of an organ during minimally invasive treatment of hemorrhage.
Methods and systems for using a biocompatible and flexible hemostatic sheet comprising a fibrous carrier structure, and reactive electrophilic groups capable of reacting with amine groups in tissue and blood, the hemostatic sheet delivered to the tissue at the bleeding site of an organ to restore hemostasis during an open surgery procedure.
Methods and systems for using a biocompatible and flexible hemostatic sheet comprising a fibrous carrier structure, and reactive electrophilic groups capable of reacting with amine groups in tissue and blood, the hemostatic sheet delivered through a trocar for restoring hemostasis to a tissue at a bleeding site of an organ during minimally invasive treatment of hemorrhage.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 15/42 - Use of materials characterised by their function or physical properties
61.
SYSTEM AND METHODS FOR USING TISSUE-ADHESIVE POROUS HEMOSTATIC PRODUCTS WITH SEVERE SURFACE AND CAVITY BLEEDING
Methods and systems for using a biocompatible and flexible hemostatic sheet comprising a fibrous carrier structure, and reactive electrophilic groups capable of reacting with amine groups in tissue and blood, the hemostatic sheet delivered to the tissue at the bleeding site of an organ to restore hemostasis during an open surgery procedure.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 15/42 - Use of materials characterised by their function or physical properties
62.
APPARATUS AND METHOD TO DETERMINE ENDOSCOPE ROLL ORIENTATION BASED ON IMAGE ANALYSIS
An apparatus includes a shaft assembly. The shaft assembly includes a working channel, a distal end, an image sensor, a navigation sensor, and a reference marker. The working channel is sized to receive a working element. The distal end includes an opening that is positioned to allow a working element in the working channel to pass through the distal end. The image sensor has a field of view distal to the distal end such that the image sensor is configured to capture at least one image providing a field of view distal to the distal end. The navigation sensor is configured to generate signals indicative of a position of the distal end in three-dimensional space. The reference marker is positioned within the field of view of the image sensor, the reference marker being fixed against movement relative to the image sensor.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
63.
APPARATUS AND METHOD TO DETERMINE ENDOSCOPE ROLL ORIENTATION BASED ON IMAGE ANALYSIS
An apparatus includes a shaft assembly. The shaft assembly includes a working channel, a distal end, an image sensor, a navigation sensor, and a reference marker. The working channel is sized to receive a working element. The distal end includes an opening that is positioned to allow a working element in the working channel to pass through the distal end. The image sensor has a field of view distal to the distal end such that the image sensor is configured to capture at least one image providing a field of view distal to the distal end. The navigation sensor is configured to generate signals indicative of a position of the distal end in three-dimensional space. The reference marker is positioned within the field of view of the image sensor, the reference marker being fixed against movement relative to the image sensor.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 1/018 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor characterised by internal passages or accessories therefor for receiving instruments
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
A system effectively narrows a patulous Eustachian tube (ET) of a patient with a guide catheter, instrument, and insert. The guide catheter includes a shaft, a lumen and a distal end configured to provide access the ET when the guide catheter is inserted into a head of the patient. The instrument comprises a shaft. The insert comprises a body configured to radially expand and retract between a non-expanded state and an expanded state. The insert is sized and shaped to be received within the first lumen when in the non-expanded state and is operable to expand to the expanded state to substantially reduce an effective diameter of the ET.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61F 2/88 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61F 11/30 - Non-electric hearing aids, e.g. ear trumpets, sound amplifiers or ear-shells
A61B 17/00 - Surgical instruments, devices or methods
A61F 2/958 - Inflatable balloons for placing stents or stent-grafts
The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
An apparatus includes a body, a shaft assembly, and a deflection actuation assembly. The shaft defines a longitudinal axis and includes a flexible distal portion. The deflection actuation assembly includes a first rotary actuator, a translatable actuation member, and a resilient member. The translatable actuation member extends through the shaft assembly and is operatively coupled with the first rotary actuator and the flexible distal portion of the shaft assembly. The first rotary actuator is rotatable by a rotational force to thereby drive the translatable actuation member longitudinally. The resilient member is positioned between the first rotary actuator and the body and is configured to apply a friction force between the first rotary actuator and the body. The friction force is operable to increase the rotational force required to rotate the first rotary actuator.
A dilation catheter includes a shaft and an expandable element. The shaft includes a proximal portion and a distal portion. The distal portion includes a tip and a bend. The tip is sized and configured to pass through an isthmus of a Eustachian tube (ET). The bend is proximal to the tip. The bend is formed at an angle configured to provide insertion of the tip into the isthmus of the ET via an ear canal associated with the ET. The expandable element is disposed at the distal portion of the shaft. The expandable element is configured to transition between a non-expanded state and an expanded state. The expandable element in the non-expanded state is configured for insertion into the ET via the isthmus. The expandable element in the expanded state is configured to dilate the ET.
A61B 1/002 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor having rod-lens arrangements
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 1/227 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for ears, i.e. otoscopes
A61B 17/24 - Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or noseTongue scrapers
A61M 29/02 - Inflatable dilatorsDilators made of swellable materials
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
A catheter system includes a body, a guide member assembly, an articulation assembly, and a partial sleeve. The guide member assembly extends distally from the body and includes a proximal rigid portion defining a longitudinal axis, a distal flexible portion, and an open distal end. The guide member assembly defines a lumen in communication with the body and the open distal end. The articulation section can flex the distal flexible portion and the open distal end relative to the longitudinal axis between a straight configuration and an articulated configuration. The partial sleeve is disposed within a portion of the lumen defined by the distal flexible portion. The partial sleeve also defines a longitudinally extending gap.
A method is used to manufacture a surgical guidewire that includes an outer coil assembly, a position sensor, a communication wire, an adhesive, a core wire, a hollow tube, and an atraumatic tip. The outer coil assembly has an outer coil that extends distally from a proximal coil retainer to a distal coil retainer. The position sensor is located distally within the outer coil assembly and is configured to be in communication with a processor via the communication wire. The core wire is between an outer coil proximal portion and the hollow tube. A distal end of the hollow tube is bonded to the atraumatic tip. The method includes affixing the atraumatic tip to the distal end of the hollow tube with the adhesive. The adhesive is constructed of instant glue.
Provided herein are methods for preparation of fibrinogen by purifying fibrinogen from a plasma fraction being depleted of prothrombin. The plasma fraction depleted of prothrombin is obtained, for example, by adding an anticoagulant to a source of blood; separating plasma from the source of blood, and extracting the prothrombin from the plasma, thereby obtaining a prothrombin depleted plasma fraction and a plasma fraction comprised of prothrombin.
An apparatus includes a shaft assembly and an electrode assembly at a distal end of the shaft assembly. The electrode assembly includes a first conductive segment extending along a first angular range at the distal end of the shaft assembly. The first conductive segment is operable to apply RF energy to tissue at a first polarity. The electrode assembly further includes a second conductive segment angularly spaced apart from the first conductive segment. The second conductive segment extends along a second angular range at the distal end of the shaft assembly. The second conductive segment is operable to apply RF energy to tissue at a second polarity such that the first and second conductive segments are operable to apply bipolar RF energy to tissue.
The present invention is directed to compressed hemostatic tablets or forms comprising a fibrous non-woven oxidized cellulose (OC or ORC) multilayer material compressed into a form stable tablet, further comprising calcium salt, with the tablets rapidly expandable on contact with blood or blood plasma. The compressed forms may further comprise a multi-arm PEG-SG and are dimensionally, preferably with regard to length and width, stable for at least 48 hours after compression. In some embodiments, the compressed forms will expand upon contact with blood from 1.5 to 5 times of tablet length in 5 seconds; from 2 to 6 times of tablet length in 20 seconds; and from 3 to 6 times of tablet length in 5 minutes. The compressed forms are effective in hemostasis in heparinized blood.
The present invention is directed to compressed hemostatic tablets or forms comprising a fibrous non-woven oxidized cellulose (OC or ORC) multilayer material compressed into a form stable tablet, further comprising calcium salt, with the tablets rapidly expandable on contact with blood or blood plasma. The compressed forms may further comprise a multi-arm PEG-SG and are dimensionally, preferably with regard to length and width, stable for at least 48 hours after compression. In some embodiments, the compressed forms will expand upon contact with blood from 1.5 to 5 times of tablet length in 5 seconds; from 2 to 6 times of tablet length in 20 seconds; and from 3 to 6 times of tablet length in 5 minutes. The compressed forms are effective in hemostasis in heparinized blood.
An apparatus includes a base housing, an actuator, and a blade. The base housing defines an upwardly presented support surface. The base housing also defines a distally oriented tip receiving recess. The distally oriented tip receiving recess is sized and configured to receive a bulbous distal tip of a dilation catheter. The actuator is movably coupled with the base housing. The blade us secured to the actuator. The actuator is operable to move the blade downwardly relative to the base housing. The blade is configured to sever a portion of a dilation catheter along a plane longitudinally interposed between the support surface and the tip receiving recess to thereby sever the bulbous distal tip of the dilation catheter in response to movement of the actuator relative to the base housing.
A61M 29/02 - Inflatable dilatorsDilators made of swellable materials
B26D 1/08 - Cutting through work characterised by the nature or movement of the cutting memberApparatus or machines thereforCutting members therefor involving a cutting member which does not travel with the work having a linearly-movable cutting member wherein the cutting member reciprocates of the guillotine type
The disclosure encompasses systems, compositions, and methods for use in vivo, including for reinforcement of soft tissue in an individual. The systems, compositions, and methods may utilize three-dimensionally printed scaffolds comprising at least a polymer scaffold and an extracellular matrix component(s), including comprised on the scaffold. The polymer scaffold may comprise particular unit cell structures of a specific design and patterns of alternating configurations of the unit cell structures.
Variations of integral navigation controls may be used in conjunction with a medical instrument to provide navigation functions for an image guided surgery (IGS) system that is in communication with the integral navigation controls. In some variations, a medical instrument with integrated navigation wheels allows movement of a cursor of the IGS system along the x and y axis by scrolling the wheel, or allows selection, zooming, or other controls by combined clicking and/or scrolling of wheels, and may be sterilized or discarded along with the device. In some other variations, a control overlay may be temporarily attached to the medical instrument to provide additional controls, such as buttons or a pointing stick, and then removed and sterilized or discarded after a procedure. In each variation, inputs may be communicated via wire or wirelessly to an IGS system to provide navigation of images during a surgical procedure.
A61B 17/24 - Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or noseTongue scrapers
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
Provided herein are hydrogel-hydrocolloid sealant compositions for use as soft-tissue sealants. The compositions can include a cross-linkable electrophilic component; a cross-linkable nucleophilic component; a swellable filler material including gelatin; and, a buffer having a pH in the range of about 9.0 to about 10.0. The compositions can have a first fluid state and a second crosslinked state, and in the crosslinked state, the electrophilic and nucleophilic components can crosslink to form a crosslinked hydrogel network where the swellable filler material including gelatin is disposed within the crosslinked network. Also provided are systems and methods of manufacturing the sealant compositions as well as methods of repairing soft tissue defects including applying the sealant compositions disclosed herein.
Provided herein are hydrogel-hydrocolloid sealant compositions for use as soft-tissue sealants. The compositions can include a cross-linkable electrophilic component; a cross-linkable nucleophilic component; a swellable filler material including gelatin; and, a buffer having a pH in the range of about 9.0 to about 10.0. The compositions can have a first fluid state and a second crosslinked state, and in the crosslinked state, the electrophilic and nucleophilic components can crosslink to form a crosslinked hydrogel network where the swellable filler material including gelatin is disposed within the crosslinked network. Also provided are systems and methods of manufacturing the sealant compositions as well as methods of repairing soft tissue defects including applying the sealant compositions disclosed herein.
A surgical instrument and related method includes an instrument body, a guide shaft distally projecting from the instrument body, and a first surgical tool. The guide shaft has a guide sidewall, a guide lumen, and a clearance opening radially extending through the guide sidewall in communication with the guide lumen. The first surgical tool has an elongate body and a distal head configured to deflect relative to the elongate body from a first position to a second position. The distal head in the first position is positioned within the guide lumen along the central axis. The distal head in the second position is deflected from the central axis and extends at least partially through the clearance opening thereby vacating at least a portion of the guide lumen for introducing a second surgical tool through the guide lumen.
A61B 17/24 - Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or noseTongue scrapers
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/015 - Control of fluid supply or evacuation
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
An apparatus includes a shaft, an expandable dilator, and at least one ventilation pathway. The shaft defines a longitudinal axis and includes a distal and proximal ends with at least one shaft lumen. The expandable dilator includes body with its own proximal and distal ends. The body is configured to transition between a contracted state and an expanded state. The body is configured to dilate a Eustachian tube of a patient in the expanded state. The at least one ventilation pathway is configured to provide ventilation from the distal end of the body to the proximal end of the body when the body is in the expanded state. In some examples, the ventilation pathway includes a set of transversely oriented vent openings formed through the shaft. In some other examples, the ventilation pathway includes a space defined between one or more radially outwardly protruding features of the expandable dilator.
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 1/227 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for ears, i.e. otoscopes
A61B 1/233 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the nose, i.e. nasoscopes
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure
A61B 8/12 - Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
The disclosure encompasses systems, compositions, and methods for use in vivo, including for reinforcement of soft tissue in an individual. The systems, compositions, and methods may utilize three-dimensionally printed scaffolds comprising at least a polymer scaffold and an extracellular matrix component(s), including comprised on the scaffold. The polymer scaffold may comprise particular unit cell structures of a specific design and patterns of alternating configurations of the unit cell structures.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
The present invention relates to flexible sheath assemblies capable of being localized in three-dimensions (i.e., determining the location and orientation) in real-time based on two-dimensional x-ray images, and related systems and methods.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 6/12 - Arrangements for detecting or locating foreign bodies
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
An apparatus includes a shaft assembly, an end effector, and a sensor. The shaft assembly defines a longitudinal axis. The end effector is positioned at a distal end of the shaft assembly. A portion of the end effector is offset from the longitudinal axis. The sensor is configured to generate a signal in response to a magnetic field. The signal is configured to indicate a position of the end effector within three-dimensional space. The sensor is coaxially positioned about the longitudinal axis.
The present invention relates to flexible sheath assemblies capable of maintaining a desired positioning at a desired tissue region during medical procedures involving use insertion and withdrawal of medical tools through the flexible sheath, and related systems and methods.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
A61L 29/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 29/14 - Materials characterised by their function or physical properties
The invention relates to biodegradable bilayer sealants for tissue closure. The sealants of the invention are composed of two layers with different compliances. The layer in immediate contact with the tissue has high compliance. The second layer located immediately above the first sealant layer has low compliance, i.e. the sealant is much stiffer. The burst pressure of the bilayer sealants is enhanced relative to either a single layer elastic sealant or a single layer stiff sealant. The improved sealant compositions herein provide a water-tight seal, can access hard to reach tears, be applied in a dry or wet environment, are low-swelling, and can repair a range of incision or tear sizes. The bilayer sealants are particularly useful for sutureless dural closure or as adjuncts to sutured dural closure. Also provided herein are methods of preparing and using the biodegradable sealant compositions.
The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.
The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.
The invention relates to biodegradable bilayer sealants for tissue closure. The sealants of the invention are composed of two layers with different compliances. The layer in immediate contact with the tissue has high compliance. The second layer located immediately above the first sealant layer has low compliance, i.e. the sealant is much stiffer. The burst pressure of the bilayer sealants is enhanced relative to either a single layer elastic sealant or a single layer stiff sealant. The improved sealant compositions herein provide a water-tight seal, can access hard to reach tears, be applied in a dry or wet environment, are low-swelling, and can repair a range of incision or tear sizes. The bilayer sealants are particularly useful for sutureless dural closure or as adjuncts to sutured dural closure. Also provided herein are methods of preparing and using the biodegradable sealant compositions.
An apparatus includes a handle assembly, a guide tube, and a dilation catheter. The guide tube extends distally from the handle assembly. At least a distal portion of the guide tube is malleable. The dilation catheter is slidably positioned in the guide tube. The dilation catheter includes a distal end, a dilator, and a position sensor. The position sensor is configured to generate a signal indicating a position of the position sensor in three-dimensional space. The dilation catheter is configured to translate relative to the guide tube.
A medical device for the treatment and irrigation of a sinus opening is described. The device allows for single-handed operation to access, dilate and irrigate a sinus opening. The device includes a sinus guide catheter, a guiding element, a balloon dilation catheter, a balloon catheter movement mechanism and a guiding element movement mechanism. A method for treating a sinus opening and irrigating a sinus is also described.
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A method of treating a patulous Eustachian tube includes forming a first pocket in a wall of a nasopharynx region proximate to a pharyngeal ostium, inserting a resiliently biased implant within the first pocket, and allowing the resiliently biased implant to expand within the first pocket to thereby urge the Eustachian tube towards a closed state. The wire implant may include a resilient stent or other resilient wire structure. In some versions, a deployment device having a balloon is used to deploy a malleable implant. This deployment device has a malleable implant disposed around the balloon, which is disposed around a guide catheter. The balloon is inflated and expands the malleable implant. The malleable implant retains the expanded shape and urges the Eustachian tube toward a closed state.
A61B 1/233 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the nose, i.e. nasoscopes
A61B 17/24 - Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or noseTongue scrapers
94.
Methods and Devices for Changing the Flow Rates of PH Modifying Fluids for Controlling Cross-Linking Rates of Reactive Components of Biocompatible Sealing Compositions
A method of making a biocompatible composition for sealing tissue includes mixing a first fluid having a first reactive component (e.g., an electrophile) and a second fluid having a second reactive component (e.g., a nucleophile) to form a mixture and expressing the mixture. During expression, a pH modifying fluid (e.g., NaOH) is added to the mixture at a rate that changes. In one embodiment, a higher ratio of the pH modifying fluid is added to the mixture during a first expressing stage and a lower ratio of said pH modifying fluid is added to the mixture during a second expressing stage. During the first expressing stage, a mixing ratio of the pH modifying fluid, the first fluid and the second fluid is 0.7-1.4:1:1. During the second expressing stage, the mixing ratio of the pH modifying fluid, the first fluid and the second fluid is 0.12-0.24:1:1.
A surgical instrument for cutting a first tissue and detecting a second tissue includes a shaft, a cutting member, and a tissue monitor system. The shaft extends along a longitudinal axis and includes a shaft lumen and a shaft opening. The cutting member is disposed within the shaft lumen and configured to cyclically move from a first position to a second position relative to the shaft. The cutting member is further configured to cut a tissue portion of the first tissue for removal therefrom. The tissue monitor system is associated with at least one of the shaft or the cutting member configured to detect the second tissue distinct from the first tissue for selectively cutting and removing the first tissue relative to the second tissue.
A method is used to manufacture a surgical instrument including a first tube, and a second tube. The first tube extends from a proximal first end portion to a distal first end portion. The second tube extends from a proximal second end portion to a distal second end portion. The second tube is positioned coaxially within the first tube with the distal second end portion positioned adjacent to the distal first end portion. The second tube defines a lumen. The sensor is secured proximal to the distal second end portion of the second tube. A die is engaged against a distal first end portion of the first tube while first tube rotates about its own longitudinal axis; and the die is simultaneously moved relative to the distal first end portion of the first tube along a predetermined path to form a predetermined shape.
The present invention is directed to coated medical devices, such as implantable and coatable devices, such as sutures, with expanded antibacterial properties, handling, knot slide and in-situ performance and processes for their manufacture and use.
The present disclosure relates to a method for preparing a haemostatic composition comprising thrombin, the method comprising the step of reconstituting a dry thrombin directly in a paste, such as a paste comprising a biocompatible polymer. The haemostatic composition comprising thrombin may be prepared from a dry thrombin composition and a paste in a single step operation and be used for treatment of a wound.
A61L 24/04 - Surgical adhesives or cementsAdhesives for colostomy devices containing macromolecular materials
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
99.
INSTRUMENT FOR ENDOSCOPIC POSTERIOR NASAL NERVE ABLATION
A surgical instrument includes an elongate shaft having a proximal shaft portion and a malleable distal shaft portion. The elongate shaft is configured to be secured to a supporting surgical instrument. An ablation head is coupled to the malleable distal shaft portion and includes at least one electrode operable to deliver RF energy to tissue for ablating the tissue. The ablation head is sized to fit within the nasal cavity of a patient with a distal end of the supporting surgical instrument. The proximal shaft portion is configured to operatively couple with an RF energy source operable to energize the at least one electrode with RF energy. The malleable distal shaft portion is configured to bend relative to a longitudinal shaft axis defined by the proximal shaft portion for selectively orienting the ablation head relative to the longitudinal shaft axis.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
An endoscope assembly includes a shaft assembly, an endoscopic camera assembly, and an anatomy elevation assembly. The shaft assembly includes a flexible outer shaft defining a lumen, a first electrical communication line, and a first fluid communication line. The endoscopic camera assembly is in communication with the first electrical communication line. The anatomy elevation assembly includes an inflatable member coupled to the flexible outer shaft. The inflatable member includes an interior surface. The first fluid communication line is in fluid communication with the inflatable member. The inflatable member is configured to transition between a deflated configuration and an inflated configuration. The interior surface is configured to define a viewing path distal to the endoscopic camera assembly while the inflatable member is in the inflated configuration.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 1/12 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with cooling or rinsing arrangements
A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
