Abstract

Immunogenic constructs and vaccines are provided along with methods of use and manufacture thereof.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 31/14 - Antivirals for RNA viruses
• C07K 19/00 - Hybrid peptides
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof

Abstract

Provided herein are compounds and methods for modulating claudin-1 (CLDN1). More particularly, provided are inhibitors claudin-1 and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer.

IPC Classes  ?

• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61P 35/00 - Antineoplastic agents
• C07D 235/14 - Radicals substituted by nitrogen atoms
• C07D 263/57 - Aryl or substituted aryl radicals

Abstract

Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a first arm link operably coupled to the base, a second arm link operably coupled to the first arm link, a third arm link operably coupled to the second arm link, and a slidable coupling component slidably coupled to the third arm link.

IPC Classes  ?

• A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61B 17/02 - Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors
• A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
• A61B 34/30 - Surgical robots

Abstract

Various medical devices and related systems, including robotic and/or in vivo medical devices, and various robotic surgical devices for in vivo medical procedures. Included herein, for example, is a robotic surgical system having a support beam positionable through an incision, and a robotic device having a device body, first and second rotating shoulder components coupled to the device body, and first and second robotic arms coupled to the first and second shoulder components, respectively.

IPC Classes  ?

• H04L 41/0631 - Management of faults, events, alarms or notifications using analysis of correlation between notifications, alarms or events based on decision criteria, e.g. hierarchy, tree or time analysis
• A61B 34/30 - Surgical robots
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
• B25J 9/00 - Programme-controlled manipulators
• B25J 9/06 - Programme-controlled manipulators characterised by multi-articulated arms
• H04L 43/08 - Monitoring or testing based on specific metrics, e.g. QoS, energy consumption or environmental parameters

Abstract

The various embodiments herein relate to systems, devices, and/or methods relating to surgical procedures, and more specifically for accessing an insufflated cavity of a patient and/or positioning surgical systems or devices into the cavity.

IPC Classes  ?

• A61B 17/34 - Trocars; Puncturing needles
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61B 17/02 - Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors
• A61B 34/30 - Surgical robots
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 90/40 - Apparatus fixed or close to patients specially adapted for providing an aseptic surgical environment
• A61B 90/50 - Supports for surgical instruments, e.g. articulated arms

Abstract

The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations and at least three degrees of freedom. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices.

IPC Classes  ?

• A61B 34/30 - Surgical robots
• A61B 34/37 - Master-slave robots
• B25J 9/00 - Programme-controlled manipulators
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements

Abstract

Plasmodium Plasmodium infection. Particularly the method compromises the step of administering a therapeutically effective amount of the disclosed compounds or compositions, with or without one or more anti-infective agents, to the patient in need of relief from said infection. Methods of uses and composition matters are within the scope of this disclosure.

Abstract

Provided herein are compounds of Formula (I), or a pharmaceutically acceptable salt thereof. Further disclosed are nanoparticles comprising one of the compounds and methods of using the same for treating drug addiction, drug dependence, drug overdose, opioid use disorder, pain, chronic pain, fibromyalgia, arthritis, or obesity.

Abstract

The various embodiments herein relate to robotic surgical systems and devices that use force and/or torque sensors to measure forces applied at various components of the system or device. Certain implementations include robotic surgical devices having one or more force/torque sensors that detect or measure one or more forces applied at or on one or more arms. Other embodiments relate to systems having a robotic surgical device that has one or more sensors and an external controller that has one or more motors such that the sensors transmit information that is used at the controller to actuate the motors to provide haptic feedback to a user.

IPC Classes  ?

• A61B 34/30 - Surgical robots
• A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• B25J 9/16 - Programme controls

Abstract

An apparatus for wrist and catheter stabilization during radial artery access includes a wrist support member and a catheter support member connected by an adjustable coupler. The wrist support member comprises a first platform with a curved surface configured to cradle a wrist in a supine or neutral position and an inclined portion to motivate extension or ulnar flexion of the wrist. The catheter support member comprises a second platform with a curved sidewall extending along at least one side of the second platform. The curved sidewall may be configured to direct a catheter toward a radial access point of the wrist when the catheter is extended across the platform portion of the catheter support member. The adjustable coupler is reconfigurable to control a height of the catheter support member from the wrist support member, as well as orientation and other height/distance parameters in some embodiments.

IPC Classes  ?

• A61M 25/02 - Holding devices, e.g. on the body

Abstract

Hybrid aerogels comprising nanofibers and microfibers are provided as well as methods of use thereof and methods of making.

IPC Classes  ?

• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
• B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
• G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers

Abstract

Provided herein are novel compositions and methods for enhancing neurolysin activity comprising: a molecule of Formula I, II, III, or IV a salt, or enantiomer thereof:

IPC Classes  ?

• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol

Abstract

A rapid smear slide development system includes a base member including a slide dock formed by an indented portion of the base member. The base member is configured to hold a slide within the slide dock. The base member has a guide rail extending at least partially along at least one edge of the base member. The system further includes a wiper configured to glide along the guide rail, wherein the wiper is configured to actuate a scraper across a specimen on the slide so that the specimen is smeared across the slide.

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• G02B 21/26 - Stages; Adjusting means therefor
• G02B 21/34 - Microscope slides, e.g. mounting specimens on microscope slides
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes

Abstract

A photoactive device, comprising a first layer comprising a polymer of formula (1) or a salt thereof, a method comprising illuminating the photoactive device, a method of making the photoactive device, and a composition comprising the polymer of formula (1) and a dye. The photoactive device operates as an inverse phototransistor in which the current is higher in the absence of illumination and lower in the presence of illumination.

IPC Classes  ?

• H10K 10/46 - Field-effect transistors, e.g. organic thin-film transistors [OTFT]
• H10K 85/10 - Organic polymers or oligomers
• H10K 85/60 - Organic compounds having low molecular weight

Abstract

The present disclosure relates to the treatment of Parkinson's disease with granulocyte-macrophage colony-stimulating factor, as well as diagnostic, prognostic and patient selection methods.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• A61K 38/19 - Cytokines; Lymphokines; Interferons

Abstract

A system for providing a bio-firewall for a medical device. The system includes a bio-firewall electronic processor configured to receive a processed network command from a device electronic processor. The bio-firewall electronic processor is also configured to determine whether the processed network command is associated with a cyberattack based on at least one rule. The bio-firewall electronic processor is also configured to, in response to determining that the processed network command is not associated with the cyberattack, enable transmission, via a non-networked communication interface, of the processed network command to a non-networked component. The bio-firewall electronic processor is also configured to, in response to determining that the processed network command is associated with a cyberattack, prevent transmission, via the non-networked communication interface, of the processed network command to the non-networked component.

IPC Classes  ?

• G06F 21/55 - Detecting local intrusion or implementing counter-measures
• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation

Abstract

Antimicrobial peptides and methods of use are provided.

IPC Classes  ?

• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61P 31/04 - Antibacterial agents
• C07K 5/11 - Tetrapeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg

Abstract

Disclosed is a Processing-In-Sensor Accelerator (PISA) that provides a flexible, energy-efficient, and high-performance solution for real-time and smart image processing in AI devices. PISA implements a coarse-grained convolution operation in Binarized-Weight Neural Networks (BWNNs) leveraging a novel compute-pixel with non-volatile weight storage at the sensor side. This reduces power consumption of data conversion and transmission to an off-chip processor. A bit-wise near-sensor in-memory computing unit processes the remaining network layers. Once the object is detected, PISA switches to typical sensing mode to capture the image for a fine-grained convolution using only a near-sensor processing unit. The circuit-to-application co-simulation results on a BWNN acceleration demonstrate minor accuracy degradation on various image datasets in coarse-grained evaluation compared to baseline BWNN models. PISA achieves a frame rate of 1000 and efficiency of 1.74 TOp/s/W. PISA reduces data conversion and transmission energy by at least 84% compared to a baseline.

IPC Classes  ?

• H04N 23/65 - Control of camera operation in relation to power supply
• G06V 10/75 - Image or video pattern matching; Proximity measures in feature spaces using context analysis; Selection of dictionaries
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G16Y 20/10 - Information sensed or collected by the things relating to location
• G16Y 40/35 - Management of things, i.e. controlling in accordance with a policy or in order to achieve specified objectives
• H04N 23/61 - Control of cameras or camera modules based on recognised objects
• H04N 23/667 - Camera operation mode switching, e.g. between still and video, sport and normal or high and low resolution modes
• H04N 25/42 - Extracting pixel data from image sensors by controlling scanning circuits, e.g. by modifying the number of pixels sampled or to be sampled by switching between different modes of operation using different resolutions or aspect ratios, e.g. switching between interlaced and non-interlaced mode
• H04N 25/709 - Circuitry for control of the power supply

Abstract

The present invention relates to compounds, compositions, and methods, for treating viral infections. In particular, entry inhibitor compounds are disclosed for treatment of coronavirus infections, including SARS-COV-1 and SARS-COV-2 infections. The compounds bind to the interface of a SARS-COV-2 spike protein receptor binding domain (RBD) and a host cell ACE-2 receptor. The entry inhibitor compounds show antiviral activity, favorable kinetics, and temporally act at the entry of SARS-COV-2 infection. In embodiments, the compounds are used as medicaments for the inhibition of viral replication including SARS-COV-1 and/or SARS-COV-2 replication, for the treatment or prophylaxis of viral infections including SARS-COV-1 and SARS-COV-2 infections, and/or for the treatment or prophylaxis of an illness due to SARS-COV-1 and SARS-COV-2 infections.

IPC Classes  ?

• A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
• A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N); Sulfinylamines (—N=SO); Sulfonylamines (—N=SO2)
• A61K 31/277 - Nitriles; Isonitriles having a ring, e.g. verapamil
• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4174 - Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61K 31/4439 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A system for reporting and investigating threats includes one or more computer processors configured to: present a chatbot via a user interface device; request response data associated with a threat inquiry via the chatbot by requesting freeform response data associated with the threat inquiry via the chatbot and transitioning to intelligent question-path selection to collect additional response data associated with the threat inquiry, wherein the intelligent question-path selection is prompted by the freeform response data; record user input response data; and identify suspicious activity based on the user input response data by performing natural language analysis and searching the user input response data for threat related words or phrases.

IPC Classes  ?

• H04L 9/40 - Network security protocols
• G06F 40/20 - Natural language analysis
• G06T 19/00 - Manipulating 3D models or images for computer graphics
• H04L 12/58 - Message switching systems
• H04L 51/02 - User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail using automatic reactions or user delegation, e.g. automatic replies or chatbot-generated messages

Abstract

Disclosed herein are various robotic surgical devices and systems that include first and second elongate bodies, first and second driveshafts disposed through the second elongate body, and an in-line shoulder joint with a robotic arm coupled thereto. In certain implementations, the in-line shoulder joint has a differential yoke and a dual shaft disposed within the yoke lumen.

IPC Classes  ?

• A61B 34/30 - Surgical robots
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 9/12 - Programme-controlled manipulators characterised by positioning means for manipulator elements electric
• B25J 17/02 - Wrist joints

Abstract

A system, genetically modified yeast and methods for sustainable production of yeast protein extract and food products containing the yeast protein extract, the system comprising an oxidative hydrothermal dissolution (OHD) apparatus for decomposing plastic and biomass into OHD output feedstock and a bioreactor configured for growing the genetically modified yeast engineered to utilize the OHD output feedstock as a carbon source.

IPC Classes  ?

• A23K 10/00 - Animal feeding-stuffs
• A23K 40/00 - Shaping or working-up of animal feeding-stuffs
• C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• C12N 15/79 - Vectors or expression systems specially adapted for eukaryotic hosts
• C12P 7/08 - Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
• C13K 1/00 - Glucose; Glucose-containing syrups

Abstract

Provided are methods for monitoring the progression of Parkinson's Disease, and methods for monitoring or determining the effectiveness of therapeutics for the treatment of Parkinson's Disease, as well as methods for treatment thereof, by assessing one or more biomarkers, such as NF-κB and/or calcineurin.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• A61K 31/198 - Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61K 38/19 - Cytokines; Lymphokines; Interferons
• A61K 38/22 - Hormones
• A61P 25/16 - Anti-Parkinson drugs

Abstract

A system for controlling exercise equipment based on user pace and motion analysis is disclosed. The system includes a control unit communicatively coupled with a center of mass (COM) sensor and one or more additional sensors. The COM sensor is configured to track a position of a body of a user on the exercise equipment over time. The one or more additional sensors are configured to track off-center movements of the user over time. The control unit is configured to modulate an adjustable parameter of the exercise equipment based on a plurality of measurements of the user's body position and off-center movements collected by the COM sensor and the one or more additional sensors over time.

IPC Classes  ?

• A63B 24/00 - Electric or electronic controls for exercising apparatus of groups
• A63B 22/02 - Exercising apparatus specially adapted for conditioning the cardio-vascular system, for training agility or co-ordination of movements with movable endless bands

Abstract

A modular personal protective equipment garment includes a body covering configured to drape over at least a portion of a frontside of a person, wherein at least a portion of the body covering includes: adjustable accordion-style pleated fabric that is configured to be expanded or compressed in order to conform to a body shape of the person; or adjustable waterfall-style folded fabric with at least one layer that is configured to be vertically maneuvered up or down in order to conform to a body shape of the person.

IPC Classes  ?

• A41D 13/12 - Surgeons' or patients' gowns or dresses
• A41D 31/12 - Hygroscopic; Water retaining
• D06J 1/12 - Forms of pleats or the like

Abstract

Flocked substrates are provided as well as methods of use thereof and methods of making.

IPC Classes  ?

• A61K 9/70 - Web, sheet or filament bases
• A61K 33/38 - Silver; Compounds thereof
• A61K 35/66 - Microorganisms or materials therefrom
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 47/44 - Oils, fats or waxes according to two or more groups of ; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
• A61P 7/04 - Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Abstract

A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.

IPC Classes  ?

• A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 1/313 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
• A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
• A61B 17/14 - Surgical saws
• A61B 17/17 - Guides for drills
• A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61B 34/37 - Master-slave robots
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

Provided herein are compounds having a structure of Formula I, Formula II, or Table 1 as disclosed herein and methods of using the disclosed compounds to inhibit IKKI3 activity. For example, the compounds of Formula I, Formula II, and Table 1 as disclosed herein are useful for methods of treating diseases and disorders including, without limitation, cancer.

IPC Classes  ?

• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed herein are methods and compositions for lipid nanoparticles encapsulating a nucleic acid encoding for a CRISPR nucleic acid complementary to a HIV-1 gene. Also disclosed are lipid nanoparticle compositions, nucleotides, cells, and methods associated with the compositions.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61K 9/127 - Liposomes
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 38/46 - Hydrolases (3)
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61P 31/18 - Antivirals for RNA viruses for HIV
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle

Abstract

HfS3-based semiconductor devices that include a substrate layer, a substrate dielectric layer formed on the substrate layer, a bulk layer formed on the substrate dielectric layer, the bulk layer comprising as-synthesized n-type HfS3, and a p-type HfS3 layer formed on the bulk layer, wherein the p-type HfS3 comprises the two-dimensional hole gas (2DHG) layer. FET devices further include first and second electrodes located on the substrate dielectric layer and forming a semiconductor channel between the first and second electrodes.

IPC Classes  ?

• H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
• H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , ,  or

Abstract

An apparatus for collecting a nasal specimen includes a device body with a nozzle at a distal end of the device body. The nozzle is configured to interface with a nasal cavity. The apparatus further includes an irrigation path and a collection path within the device body. The collection path may be separate from the irrigation path. The irrigation path is configured to direct a fluid from an irrigation chamber into the nasal cavity in order to dislodge a sample from the nasal cavity. When the fluid flows back out of the nasal cavity, the collection path is configured to direct at least a portion of the fluid and the sample dislodged from the nasal cavity into a collection chamber.

IPC Classes  ?

• A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
• A61M 3/02 - Enemata; Irrigators

Abstract

A safety monitoring system for operators of agricultural vehicles and other heavy machinery includes a camera configured to be mounted within an operating cabin and a controller that is configured to: receive one or more images or video frames of an operator at an entrance of an operating cabin from the camera; detect a predefined set of body joints and features within the one or more images or video frames using a skeleton model; estimate the operator's posture with respect to the entrance of the operating cabin based on the detected body joints and features; and assign a risk level to the one or more images or video frames based on an estimate of the operator's posture with respect to the entrance of the operating cabin using a trained classifier, wherein the trained classifier is based on a machine learning model.

IPC Classes  ?

• B60R 1/00 - Optical viewing arrangements; Real-time viewing arrangements for drivers or passengers using optical image capturing systems, e.g. cameras or video systems specially adapted for use in or on vehicles
• B62D 33/06 - Drivers' cabs
• G08B 21/02 - Alarms for ensuring the safety of persons
• G06N 3/08 - Learning methods
• G06N 20/00 - Machine learning
• B60K 35/28 - characterised by the type of the output information, e.g. video entertainment or vehicle dynamics information; characterised by the purpose of the output information, e.g. for attracting the attention of the driver

Abstract

Systems, methods, and devices for providing a phase-separated porous nanocomposite including a porous polymer substrate with a plurality of pores and conductive silver nanowire disposed therein. The pores within the nanocomposite permit stretching and strain loading condition without a substantial impact on electrical properties such as electrical resistance.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes
• H01B 1/16 - Conductive material dispersed in non-conductive inorganic material the conductive material comprising metals or alloys
• H01B 3/30 - Insulators or insulating bodies characterised by the insulating materials; Selection of materials for their insulating or dielectric properties mainly consisting of organic substances waxes

Abstract

An oral specimen collection apparatus comprises a deformable container including one or more collection ports, wherein a negative pressure is produced within the deformable container when the deformable container is compressed within an oral cavity, and wherein the negative pressure causes a specimen to be suctioned into the deformable container through the one or more collection ports as the deformable container decompresses.

IPC Classes  ?

• A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements

Abstract

The present invention provides porous microparticles, particularly layer-by-layer microparticles, and methods of use thereof.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 9/16 - Agglomerates; Granulates; Microbeadlets
• A61P 31/14 - Antivirals for RNA viruses

Abstract

Some implementations of an endovascular device include a stent graft with an expandable tubular metallic frame and a covering material disposed on at least a portion of the metallic frame. The stent graft defines a lumen therethrough. In a particular embodiment, a first balloon is disposed around an outer periphery of the stent graft, a second balloon is disposed around the outer periphery of the stent graft and spaced apart from the first balloon, and a third balloon is disposed within the stent graft lumen between the first balloon and the second balloon. The third balloon can be inflated to fully or partially occlude the lumen. The first and second balloons can be individually inflated to fully or partially shunt blood flow from a blood vessel through the stent graft. In some embodiments, sensors and an automated control unit are included to automate the operations of the endovascular device.

IPC Classes  ?

• A61F 2/958 - Inflatable balloons for placing stents or stent-grafts
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
• A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
• A61F 2/07 - Stent-grafts

Abstract

Compositions and methods for treating and repairing nerve transections are provided.

IPC Classes  ?

• C09J 171/10 - Polyethers derived from hydroxy compounds or from their metallic derivatives from phenols
• C09J 161/20 - Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen
• C09J 175/02 - Polyureas
• C09J 161/24 - Condensation polymers of aldehydes or ketones with only compounds containing hydrogen attached to nitrogen of aldehydes with acyclic or carbocyclic compounds with urea or thiourea

Abstract

The disclosure features lipid nanoparticle (LNP) compositions comprising mRNA molecules encoding human granulocyte macrophage colony stimulating factor (GM-CSF) polypeptides and uses thereof in the treatment of Parkinson's Disease. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding human GM-CSF for use in such treatment.

IPC Classes  ?

• A61K 38/19 - Cytokines; Lymphokines; Interferons
• A61K 9/51 - Nanocapsules
• A61K 31/7115 - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
• A61P 25/16 - Anti-Parkinson drugs

Abstract

A powered air purifying faceshield (PAPF) includes a headgear with a face shield frame pivotally coupled to the headgear. The face shield frame is configured to support a face shield that is mounted to the face shield frame. The PAPF further includes a battery powered fan assembly mounted above the face shield frame. The battery powered fan assembly is configured to direct ambient air through an air filter before the air is blown into a region behind the face shield. The PAPF further includes a neck shroud that is coupled to the face shield frame. The neck shroud may extend from a lower edge of the face shield frame. The neck shroud includes one or more filtered exhaust ports for releasing air from the region behind the face shield.

IPC Classes  ?

• A62B 18/02 - Masks
• A62B 18/08 - Component parts for gas-masks or gas-helmets, e.g. windows, straps, speech transmitters, signal-devices
• A62B 7/10 - Respiratory apparatus with filter elements
• A62B 9/04 - Couplings; Supporting frames

Abstract

An intravascular cutting device described herein uses high-pressure water, saline, or other fluid to cut tissue and other materials including but not limited to calcified tissue, stents, stent grafts, and other devices. In some embodiments, the cutting device includes a working end that has a nozzle with a hole to allow the release of a high-pressure fluid jet. Opposite of the nozzle is a catch plate or deflector anvil that prevents the fluid jet from cutting healthy tissue. The device user will place the item to be cut between the nozzle and catch plate and then advance the device along the item to be cut as the fluid jet is activated, thus cutting the object as it advances.

IPC Classes  ?

• A61B 17/3203 - Fluid jet cutting instruments
• A61F 2/07 - Stent-grafts
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61B 17/32 - Surgical cutting instruments
• A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
• A61M 25/09 - Guide wires

Abstract

Disclosed herein are lipid nanoparticles comprising plurality of lipids, a targeting moiety for an HIV-1 chemokine receptor, and a CRISPR nucleic acid complementary to an HIV-1 gene, pharmaceutical compositions and methods of use thereof.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 31/12 - Antivirals

Abstract

The present invention provides prodrugs and methods of use thereof.

IPC Classes  ?

• A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
• A61K 9/14 - Particulate form, e.g. powders
• A61P 31/18 - Antivirals for RNA viruses for HIV

Abstract

Aspects of the present disclosure relate to systems and methods for analyzing a tumor, and more specifically, analyzing a tumor to identify a biological aggressiveness of the tumor. One example method for tumor analysis includes: receiving one or more input features associated with a geometric shape of a tumor, the one or more input features including at least a value indicating a circularity of the tumor; determining, via a machine learning component, a characteristic of the tumor based on the one or more input features, the characteristic being indicative of patient survivability; and outputting an indication of the characteristic.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06T 7/00 - Image analysis
• G06T 7/50 - Depth or shape recovery
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies

Abstract

The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector.

IPC Classes  ?

• A61B 18/14 - Probes or electrodes therefor

Abstract

Systems and methods for determining pulse arrival time utilizing sensors coupled to mobile electronic devices are described. A system embodiment includes, but is not limited to, a sensor configured to provide electrocardiogram (ECG) data; an optical sensor configured to provide optical data; and a controller configured to access each of the ECG data and the optical data, the controller configured to: isolate and normalize R-wave information from the ECG data, isolate information associated with the cardiac rhythm from the isolated and normalized R-wave information to provide pulse waves, determine temporal characteristics of the pulse waves, convert and normalize the optical data in a wavelet time-frequency plane, and calculate pulse arrival time utilizing each of the temporal characteristics of the pulse waves and the converted and normalized optical data.

IPC Classes  ?

• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval

Abstract

Systems and methods for determining pulse arrival time utilizing sensors coupled to mobile electronic devices are described. A system embodiment includes, but is not limited to, a sensor configured to provide electrocardiogram (ECG) data; an optical sensor configured to provide optical data; and a controller configured to access each of the ECG data and the optical data, the controller configured to: isolate and normalize R-wave information from the ECG data, isolate information associated with the cardiac rhythm from the isolated and normalized R-wave information to provide pulse waves, determine temporal characteristics of the pulse waves, convert and normalize the optical data in a wavelet time-frequency plane, and calculate pulse arrival time utilizing each of the temporal characteristics of the pulse waves and the converted and normalized optical data.

IPC Classes  ?

• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

Methods and compositions for treating, inhibiting, and/or preventing diseases or disorders associated with aberrant bromodomain-containing protein 4 (BRD4) and phosphoinositide 3-kinase (PBK) activity are disclosed, the methods comprise contacting a solution, cell, tissue, or subject expressing BRD4 and PBK with a compound having Benzopyran-4-One core.

IPC Classes  ?

• C07D 311/22 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61P 35/00 - Antineoplastic agents
• C07D 319/08 - 1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems

Abstract

The present invention provides novel compositions and methods for inducing and/or activating regulatory T cells (Treg). Wherein a method of treating, inhibiting, and/or preventing a disease or disorder in a subject in need thereof, said method comprising administering at least two immune modulators to said subject, is disclosed.

IPC Classes  ?

• A61K 38/19 - Cytokines; Lymphokines; Interferons
• A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
• A61K 38/20 - Interleukins
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/16 - Anti-Parkinson drugs

Abstract

Multifunctional hydrogels and methods of use thereof are provided.

IPC Classes  ?

• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/69 - Boron compounds
• A61L 27/50 - Materials characterised by their function or physical properties

Abstract

Systems and methods for treating and inhibiting wound infections employ a hydrogel ionic circuit (HIC)-based device for therapeutic iontophoresis and/or biofilm debridement. The HIC-based device includes: a first chamber containing a salt solution; a second chamber containing a therapeutic or buffer solution, the second chamber being configured to interface with a surface overlaying a target region; a hydrogel membrane separating the first chamber from the second chamber; and an electrode configured to apply an electrical current to the first chamber of the working device to induce an ion current in the salt solution, wherein the ion current acts on the second chamber to iontophoretically transport therapeutic molecules across the surface overlaying the target region and/or debride biofilm at the surface overlaying the target region.

IPC Classes  ?

• A61N 1/04 - Electrodes
• A61K 31/35 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
• A61K 38/12 - Cyclic peptides

Abstract

Provided herein are compounds of compounds, or pharmaceutically acceptable salts thereof, having the structure of Formula (0): A-L-B, wherein A is a AKR1C3 inhibitor and/or binder moiety; B is a proteolysis targeting moiety; and L is a linker moiety, as described herein. The disclosure also provides pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier or excipient and further provides methods of treating, inhibiting, and/or diseases (e.g., cancer).

IPC Classes  ?

• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 31/015 - Hydrocarbons carbocyclic
• A61K 31/33 - Heterocyclic compounds

Abstract

A portable evacuation system includes a pressure vessel configured to retain a vacuum chamber. The pressure vessel includes a valve port configured to receive a valve. The portable evacuation system also includes a catheter having an inlet side and an outlet side. The inlet side is configured to interface with the vacuum chamber via the valve port. The portable evacuation system also includes a balloon disposed about an outer surface of the catheter. The balloon is disposed proximate to the outlet side of the catheter.

IPC Classes  ?

• A61M 1/00 - Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
• A61M 25/04 - Holding devices, e.g. on the body in the body, e.g. expansible
• A61M 25/10 - Balloon catheters
• A61M 25/00 - Catheters; Hollow probes

Abstract

Provided herein are compounds having a structure of formula (A), or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rd, and n are described herein. Also provided herein are compositions comprising compounds of Formula (A) and methods of using compound of Formula (A) in treating, inhibiting, and/or preventing disease such as cancers (e.g., prostate cancer).

IPC Classes  ?

• C07C 233/65 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia

Abstract

Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly.

IPC Classes  ?

• A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61B 34/30 - Surgical robots
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• B25J 9/00 - Programme-controlled manipulators
• A61B 17/29 - Forceps for use in minimally invasive surgery

Abstract

A nasal specimen collection apparatus comprises: a nasal pathway irrigator including an irrigation chamber that defines an irrigation path for directing fluid into a nasal pathway to dislodge a sample from within the nasal pathway; a nasal sample collector including a collection chamber that surrounds the nasal pathway irrigator, wherein the collection chamber has an outer rim that is configured to interface with the nasal pathway, and wherein the collection chamber defines a collection path for recapturing at least a portion of the fluid to collect the sample that was dislodged from within the nasal pathway; and an annular shell that surrounds the nasal sample collector with an annular cavity formed in between the annular shell and the collection chamber, wherein the annular shell is configured to interface with a sample tube so that contents of the collection chamber can be emptied into the sample tube.

IPC Classes  ?

• A61M 3/02 - Enemata; Irrigators
• A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
• A61H 35/04 - Baths for specific parts of the body, e.g. breast douches for the nose

Abstract

Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a first arm link operably coupled to the base, a second arm link operably coupled to the first arm link, a third arm link operably coupled to the second arm link, and a slidable coupling component slidably coupled to the third arm link.

IPC Classes  ?

• A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
• A61B 17/02 - Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors
• A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
• A61B 34/30 - Surgical robots
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets

Abstract

The various embodiments disclosed herein relate to improved robotic surgical systems, including robotic surgical devices having improved arm components and/or biometric sensors, contact detection systems for robotic surgical devices, gross positioning systems and devices for use in robotic surgical systems, and improved external controllers and consoles.

IPC Classes  ?

• A61B 34/30 - Surgical robots

Abstract

Various examples are provided related to underwater grasping of objects. In one example, an underwater adhesive system includes switchable adhesive elements, proximity sensing elements, and a controller. Each of the switchable adhesive elements can be pneumatically actuated to control adhesion or release of that switchable adhesive element. One of the switchable adhesive elements can be positioned adjacent to each of the proximity sensing elements. The controller can control adhesion of the switchable adhesive elements based at least in part upon signals from the proximity sensing elements.

IPC Classes  ?

• B63G 8/00 - Underwater vessels, e.g. submarines
• G01V 1/38 - Seismology; Seismic or acoustic prospecting or detecting specially adapted for water-covered areas

Abstract

The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various modular medical devices for in vivo medical procedures.

IPC Classes  ?

• A61B 34/30 - Surgical robots
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
• A61B 17/29 - Forceps for use in minimally invasive surgery
• A61B 34/37 - Master-slave robots

Abstract

The present disclosure relates to methods of producing insect pheromone precursors and genetically modified plants capable of producing insect pheromone precursors. The genetically modified plants include a heterologous gene encoding at least one silencing suppressor protein and at least one enzyme selected from the group consisting of a fatty acyl desaturase, a fatty acyl elongase, a fatty acyl reductase, and an acyl-CoA oxidase.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.

IPC Classes  ?

• A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• A61K 9/107 - Emulsions
• A61K 47/10 - Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• C07J 41/00 - Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
• C07J 51/00 - Normal steroids with unmodified cyclopenta[a]hydrophenanthrene skeleton not provided for in groups

Abstract

Sample collection devices are provided as well as methods of use thereof and methods of making.

IPC Classes  ?

• A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
• A61L 15/26 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
• A61F 13/36 - Surgical swabs, e.g. for absorbency or packing body cavities during surgery
• A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators

Abstract

Surface modified scaffolds are provided as well as methods of use thereof and methods of making.

IPC Classes  ?

• A61L 27/34 - Macromolecular materials
• A61L 27/56 - Porous or cellular materials
• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances

Abstract

Provided herein are aryl hydantoin compounds having the structure of Formula (I) wherein X, R1, R2, R3, R4e.ge.g., Schistosomiasis).

IPC Classes  ?

• A61K 31/4164 - 1,3-Diazoles
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61P 33/12 - Schistosomicides
• C07D 233/76 - Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom

Abstract

Inhibitory nucleic acid molecules are provided as well as methods of use thereof. Specifically, the disclose provides an Inhibin BetaA (inhba) inhibitory nucleic acid molecule, which is an antisense oligonucleotide, siRNA, or shRNA. Further disclosed are sequences that are targeted by the inhba inhibitory nucleic acid molecule; and methods of treating a disease or disorder in a subject comprising administering an inhba inhibitory nucleic acid molecule to the subject, wherein the disease or disorder is selected from the group consisting of cancers, autoimmune diseases, fibrotic disorders, blood disorders, allergies and allergic diseases, heart failure, neurodegenerative diseases, cachexia and inflammatory diseases.

IPC Classes  ?

• A61K 9/127 - Liposomes
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61P 35/00 - Antineoplastic agents
• C12N 15/00 - Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

Abstract

Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally relates to compositions, methods, and kits for DNA editing using single-stranded DNA. Compositions and methods for modifying gene expression using artificial microRNAs (amiRNA) are also contemplated.

IPC Classes  ?

• C12N 9/96 - Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• A01K 67/027 - New breeds of vertebrates

Abstract

Provided are engineered cells that include a T cell receptor (TCR) or antigen-binding fragment thereof that binds to amyloid beta, and methods of engineering and using such cells, such as in methods of treatment, diagnosis, and monitoring of therapeutic effectiveness, of diseases or conditions, such as those associated with amyloid beta, e.g., Alzheimer's Disease.

IPC Classes  ?

• C07K 14/725 - T-cell receptors
• A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

A passive exosuit for asymmetry rehabilitation includes: a first article of apparel configured to be worn on at least a portion of the first leg of the user; a second article of apparel configured to be worn on at least a portion of the second leg of the user; a third article of apparel configured to be worn on at least a portion of a torso of the user; and a plurality of elastic bands asymmetrically connecting the third article of apparel to the first and second articles of apparel. The elastic bands include at least one anterior band configured to impede hip extension of the first leg of the user and at least one posterior band configured to impede hip flexion of the second leg of the user.

IPC Classes  ?

• A61H 1/02 - Stretching or bending apparatus for exercising
• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

Abstract

Nanofiber structures are provided as well as methods of use thereof and methods of making.

IPC Classes  ?

• A61L 27/26 - Mixtures of macromolecular materials
• A61L 27/56 - Porous or cellular materials
• A61L 27/34 - Macromolecular materials
• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances

Abstract

The present invention provides metformin nanoparticles and methods of use thereof.

IPC Classes  ?

• A61K 31/13 - Amines, e.g. amantadine
• A61K 9/10 - Dispersions; Emulsions
• A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
• A61K 47/56 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule

Abstract

Provided herein are prodrugs of a nucleoside, a nucleotide, or a nucleobase, or an analog thereof, wherein said prodrug is a compound of formula I, or a pharmaceutically acceptable salt thereof: (I). Further disclosed are nanoparticles comprising one of the compounds and methods of using the same for treating a medical condition, e.g., HIV infection.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/505 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
• A61K 31/33 - Heterocyclic compounds

Abstract

Provided herein are prodrugs of integrase inhibitors, having the structure of formula I, or a pharmaceutically acceptable salt thereof: in which A is a moiety derived from an integrase inhibitor, particularly one of dolutegravir (DTG), cabotegravir (CAB), raltegravir (RAL), elvitegravir (EVG), bictegravir (BIC), BI 224436, and MK-2048; L1 is -(C=O)-O- or -O-(C=O)-, L2 is -(C=O)-X- or -X-(C=O)-, where X is O, NR1, or S, R1 being H or alkyl; m and n each, independently, are integers of 0-3; and R is the alkyl chain of a fatty acid. Nanoparticles comprising one of the prodrugs and methods of using the same for treating a retroviral infection are also provided.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 31/47 - Quinolines; Isoquinolines
• A61K 31/513 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 498/14 - Ortho-condensed systems
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/14 - Particulate form, e.g. powders
• A61P 31/12 - Antivirals

Abstract

The present invention provides liquid crystals and compositions thereof (e.g., liquid crystal-based scaffolds). The present invention also provides the methods for generating said liquid crystals and compositions thereof (e.g., liquid crystal-based scaffolds) as well as uses thereof in cell-culturing and tissue-generating.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
• C09K 19/36 - Steroidal liquid crystal compounds

Abstract

Methods and systems for medical device diagnostics and reporting. One system including an electronic processor configured to receive a new medical device dataset associated with a medical device. The electronic processor is also configured to determine an operation classification of the medical device using a model utilizing training information. The training information includes a plurality of archived medical device datasets and an associated operation classification for each of the plurality of archived medical device datasets. The electronic processor is also configured determine an operation status of the medical device based on the operation classification. The electronic processor is also configured to generate and provide a notification based on at least the operation status of the medical device.

IPC Classes  ?

• G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades

Abstract

There is disclosed a method for administration of a formulation of resiniferatoxin (RTX) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient to chemically denervate vanilloid 1 receptor (TRPV1)-expressing CSAR (cardiac sympathetic afferent reflex) afferents. There is further disclosed a method for treating heart failure or hypertension and its related indications selected from the group consisting of increased sympatho-excitation, cardiac hypertrophy, increased left ventricular end diastolic pressure (LVEDP), lung edema, and combinations thereof, comprising administering an effective amount of RTX directly to a tissue site selected from the group consisting of epicardium, a T1-T4 dorsal root ganglion and intrathecally to the T1-T4 region of the spinal column.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel

Abstract

Nanofiber swabs are provided as well as methods of use thereof and methods of making.

IPC Classes  ?

• A61F 13/38 - Swabs having a stick-type handle
• A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
• A61L 15/32 - Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
• A61L 15/40 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof
• A61L 15/60 - Liquid-swellable gel-forming materials, e.g. super-absorbents

Abstract

A hydrogel ionic circuit (HIC) electrode configured for electrical stimulation and/or drug therapy (e.g., iontophoresis) is disclosed. The HIC electrode includes a chamber containing a salt solution. The chamber is at least partially bound by a hydrogel membrane that defines a barrier for the salt solution. The HIC electrode further includes an electrode configured to apply an electrical current to the chamber to induce an ion current in the salt solution, wherein the hydrogel membrane is ionically conductive and configured to transmit the ion current.

IPC Classes  ?

• A61N 1/30 - Apparatus for iontophoresis or cataphoresis
• A61N 1/04 - Electrodes

Abstract

The present disclosure is directed to methods of genetically subtyping peripheral t-cell lymphoma.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
• A61P 35/00 - Antineoplastic agents
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

Provided herein are compounds having a structure of formula (I) and methods of using the disclosed compounds to inhibit IKKβ activity.

IPC Classes  ?

• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61P 35/04 - Antineoplastic agents specific for metastasis

Abstract

Aspects disclosed herein include an electrochemical cell comprising: an anode comprising: a first surface comprising aluminum metal or an aluminum alloy; a liquid metal on the first surface, the liquid metal being in liquid state during operation of the battery and the liquid metal having a different composition than that of the first surface; and aluminum-rich dendrites extending from the first surface and in contact with an electrolyte; a positive electrode; and the electrolyte between the positive electrode and the negative electrode, the electrolyte being capable of conducting ions.

IPC Classes  ?

• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• H01M 4/46 - Alloys based on magnesium or aluminium
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 10/0566 - Liquid materials

Abstract

Provided herein are compounds having a structure of Formula I, Formula II, or Table 1 as disclosed herein and methods of using the disclosed compounds to inhibit a beta amyloid (Aβ) - amyloid-binding alcohol dehydrogenase (ABAD) protein-protein interaction, such as to inhibit beta amyloid (Aβ) - amyloid-binding alcohol dehydrogenase (ABAD) binding. For example, the compounds of Formula I, Formula II, and Table 1 as disclosed herein are useful for methods of treating diseases and disorders including, without limitation, Alzheimer's disease,Parkinson's disease, motor neuron disease, or spinal muscular atrophy.

IPC Classes  ?

• C07D 239/70 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

An apparatus for assessing user frailty is disclosed. In embodiments, the apparatus includes a housing that defines (or is defined by) a body and a handle coupled to the body. The apparatus includes a force sensor at least partially disposed within the handle. The apparatus further includes an inertial sensor at least partially disposed within the housing. The apparatus may further include a user interface device disposed within a cavity of the body. The user interface device may be coupled to the force sensor and the inertial sensor via one or more signal paths. In embodiments, the user interface device includes a controller with a touchscreen coupled to the controller.

IPC Classes  ?

• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• G06F 9/451 - Execution arrangements for user interfaces
• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/22 - Ergometry; Measuring muscular strength or the force of a muscular blow
• A61B 5/01 - Measuring temperature of body parts
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

Provided herein are compounds and methods for modulating the mitochondrial respiratory complex II (CII) and vascular endothelial growth factor (VEGF) pathways. More particularly, provided are inhibitors of the mitochondrial respiratory complex II (CII) and vascular endothelial growth factor (VEGF) pathways and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer.

IPC Classes  ?

• C07D 285/08 - 1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles

Abstract

An infectious aerosol capture mask (IACM) includes a face tent coupled to a suction tube adapter. The face tent includes a proximal opening configured to be disposed over the mouth and nose of a patient. The face tent further includes a distal opening with a smaller diameter than the proximal opening. A coupler is configured to secure the suction tube adapter to the distal opening of the face tent. The suction tube adapter includes a suction port configured to be coupled to a suction tube for active capture of infectious aerosol and left unconnected for passive capture of infectious aerosol. A viral filter is disposed between the suction port and the face tent to capture infectious aerosols expelled by the patient. The IACM further includes one or more one-way valves that are configured to permit airflow into the face tent.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
• A61M 16/06 - Respiratory or anaesthetic masks
• A61M 16/10 - Preparation of respiratory gases or vapours
• A61M 16/20 - Valves specially adapted to medical respiratory devices
• A61M 16/08 - Bellows; Connecting tubes
• A41D 13/11 - Protective face masks, e.g. for surgical use, or for use in foul atmospheres

Abstract

A number of improvements are provided relating to computer aided surgery. The improvement relates to both the methods used during computer aided surgery and the devices used during such procedures. Some of the improvement relate to controlling the selection of which data to display during a procedure and/or how the data is displayed to aid the surgeon. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled automatically to improve the efficiency of the procedure. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure.

IPC Classes  ?

• A61B 34/20 - Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61B 17/14 - Surgical saws
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 34/30 - Surgical robots
• A61B 90/11 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints
• A61B 17/15 - Guides therefor
• A61B 17/16 - Osteoclasts; Drills or chisels for bones; Trepans
• A61B 17/17 - Guides for drills
• A61B 34/00 - Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
• A61B 90/90 - Identification means for patients or instruments, e.g. tags
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61B 17/32 - Surgical cutting instruments
• A61F 2/46 - Special tools for implanting artificial joints

Abstract

A medical device configured to engage a vertebrae body and a method of assembling a medical device. The device may include a head piece containing two distraction blades and a mechanism operable by the handle for driving apart/together the distraction blades. The device may further include an interface on the handle operable to engage and drive the mechanism of the head piece. The removable handle may include a grip portion separated from the interface by an elongate rod so that the handle, when attached to the head piece, is operable for insertion of the head piece into a corridor of a patient, and for driving the mechanism. With the medical device, a surgeon may operate to expose the disc space on at least one of the cervical, thoracic, or lumbar vertebrae.

IPC Classes  ?

• A61B 17/02 - Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors

Abstract

Methods for diagnosing non-alcoholic steatohepatitis (NASH) and NASH with or without advanced liver fibrosis in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of NASH versus simple steatosis and NASH with advanced liver fibrosis versus NASH without advanced liver fibrosis. The invention also provides methods treating NASH (e.g., NASH with or without advanced liver fibrosis) by administering a biomarker or an agent that modulates a biomarker of NASH or fibrosis. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

IPC Classes  ?

• G01N 33/576 - Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

Immunogenic constructs and vaccines are provided along with methods of use and manufacture thereof.

IPC Classes  ?

• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/12 - Viral antigens

Abstract

Provided herein are compounds and methods for modulating the NFKB pathway. More particularly, provided are inhibitors of the NFkB pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, such as ovarian cancer.

IPC Classes  ?

• C07D 491/107 - Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
• C07D 493/04 - Ortho-condensed systems
• A61P 35/00 - Antineoplastic agents
• A61P 15/08 - Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Abstract

Provided herein are compounds of Formula (I), or a pharmaceutically acceptable salt thereof: Formula (I). Further disclosed are nanoparticles comprising one of the compounds and methods of using the same for treating drug addiction, drug dependence, drug overdose, opioid use disorder, pain, chronic pain, fibromyalgia, arthritis, or obesity.

IPC Classes  ?

• A61K 31/33 - Heterocyclic compounds
• A61K 31/335 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
• A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline

Abstract

Various medical devices and related systems, including robotic and/or in vivo medical devices, and various robotic surgical devices for in vivo medical procedures. Included herein, for example, is a robotic surgical system having a support beam positionable through an incision, and a robotic device having a device body, first and second rotating shoulder components coupled to the device body, and first and second robotic arms coupled to the first and second shoulder components, respectively.

IPC Classes  ?

• B25J 9/02 - Programme-controlled manipulators characterised by movement of the arms, e.g. cartesian co-ordinate type
• H04L 41/0631 - Management of faults, events, alarms or notifications using analysis of correlation between notifications, alarms or events based on decision criteria, e.g. hierarchy, tree or time analysis
• A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
• B25J 9/00 - Programme-controlled manipulators
• B25J 9/06 - Programme-controlled manipulators characterised by multi-articulated arms
• A61B 34/30 - Surgical robots
• H04L 43/08 - Monitoring or testing based on specific metrics, e.g. QoS, energy consumption or environmental parameters
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Goods & Services

Clothing, namely, shirts, sweatshirts, sweatpants, polo shirts, jackets, infantwear, headwear, and shorts Education and Entertainment services, namely, providing courses of instruction at the university level; arranging and conducting athletic events and tournaments; arranging and conducting exhibitions for sporting events

Abstract

Provided herein are compounds and methods for modulating claudin-1 (CLDN1). More particularly, provided are inhibitors claudin-1 and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer.

IPC Classes  ?

• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• C07C 275/28 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
• C07C 335/16 - Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
• A61P 35/00 - Antineoplastic agents

Abstract

In accordance with some embodiments, systems, methods, and media for efficient peridynamic modeling with bounded domains are provided. In some embodiments, a method comprises: receiving a plurality of parameters associated with a non-local model that has a convolutional structure to be used for one or more simulations, wherein the plurality of parameters includes a shape of a domain Ω, a horizon size δ, and one or more boundary constraints; drawing a periodic box that includes the domain Ω and a boundary layer Γ extending from the domain Ω; imposing the one or more boundary constraints on the boundary layer Γ; performing a simulation of a physical process using the non-local model and convolutional properties of Fourier transforms; and causing a result of the simulation to be presented.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation
• G06F 17/14 - Fourier, Walsh or analogous domain transformations

Abstract

Hernia meshes are provided as well as methods of use thereof and methods of making.

IPC Classes  ?

• A61F 2/00 - Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• A61L 31/04 - Macromolecular materials
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances
• A61L 31/10 - Macromolecular materials

Abstract

Compositions and methods for delivering therapeutics to a subject are provided.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 31/04 - Antibacterial agents

Abstract

Nucleic acids for use in CRISPR systems for treating HIV infections are disclosed. Pharmaceutical compositions incorporating the nucleic acids are disclosed as are methods of treating HIV using the nucleic acids.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 15/86 - Viral vectors
• A61P 31/18 - Antivirals for RNA viruses for HIV

Abstract

An apparatus for wrist and catheter stabilization during radial artery access includes a wrist support member and a catheter support member connected by an adjustable coupler. The wrist support member comprises a first platform with a curved surface configured to cradle a wrist in a supine or neutral position and an inclined portion to motivate extension or ulnar flexion of the wrist. The catheter support member comprises a second platform with a curved sidewall extending along at least one side of the second platform. The curved sidewall may be configured to direct a catheter toward a radial access point of the wrist when the catheter is extended across the platform portion of the catheter support member. The adjustable coupler is reconfigurable to control a height of the catheter support member from the wrist support member, as well as orientation and other height/distance parameters in some embodiments.

IPC Classes  ?

• A61M 5/52 - Arm-rests
• A61M 25/02 - Holding devices, e.g. on the body