Abstract

The present invention relates to a cyclopropenium salt bearing an electron withdrawing group suitable for use as a reagent in cyclopropenylation reactions of formula (I). The invention also relates to a process for their preparation, the use thereof as cyclopropenylation reagent, to an electrophilic aromatic substitution process of cyclopropenylation, and to a process for cyclopropenylation of organometallic substrates using said reagents. The present invention relates to a cyclopropenium salt bearing an electron withdrawing group suitable for use as a reagent in cyclopropenylation reactions of formula (I). The invention also relates to a process for their preparation, the use thereof as cyclopropenylation reagent, to an electrophilic aromatic substitution process of cyclopropenylation, and to a process for cyclopropenylation of organometallic substrates using said reagents.

IPC Classes  ?

• C07C 69/743 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of acids with a three-membered ring and with unsaturation outside the ring
• C07D 209/08 - IndolesHydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
• C07D 209/38 - Oxygen atoms in positions 2 and 3, e.g. isatin
• C07D 333/24 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 307/80 - Radicals substituted by oxygen atoms
• C07D 213/69 - Two or more oxygen atoms
• C07D 223/24 - Dibenz [b, f] azepinesHydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
• C07D 495/04 - Ortho-condensed systems
• C07D 295/088 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
• C07J 51/00 - Normal steroids with unmodified cyclopenta[a]hydrophenanthrene skeleton not provided for in groups
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 239/04 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
• C07F 5/02 - Boron compounds
• C07D 213/64 - One oxygen atom attached in position 2 or 6
• C07C 67/00 - Preparation of carboxylic acid esters
• C07D 207/22 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• C07D 209/26 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
• C07C 233/15 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
• C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Abstract

A method for the preparation of an electrode suitable for electrocatalysis includes an electrocatalytically active material, in particular an anode for alkaline water hydrolysis. An electrode can be obtained by the method and used in electrocatalysis. The method includes providing a carrier suitable for an electrode that includes an electron conductive material, providing a precursor mixture suitable for combustion synthesis, transferring the precursor material to the electron conductive material, and heating the electrode precursor to produce self-ignition of the transferred precursor mixture.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/061 - Metal or alloy
• C25B 11/031 - Porous electrodes
• C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide

Abstract

1 are as described herein. Also disclosed are a pharmaceutical composition containing the compound and a method of using the compound for treating cancer, such as renal cancer.

IPC Classes  ?

• C07D 493/08 - Bridged systems
• A61P 35/00 - Antineoplastic agents
• C07D 495/08 - Bridged systems
• C07D 471/08 - Bridged systems

Goods & Services

Chemicals used in industry, science and agriculture; Catalysts; Chemical additives; Reagent for chemical analyses; Chemical reagents, other than for medical or veterinary purposes; Chemical reagent mixtures in kit form, other than for medical or veterinary use; Chemical preparations for use in industry; Vulcanisation accelerators [chemical preparation]; Extenders [chemical substances]; Chemical substances for analysis in laboratories; Inorganic chemical compounds; Acidproof chemical compositions. Scientific and measuring apparatus and instruments; Data processing equipment and software for controlling scientific apparatus and instruments; Laboratory apparatus and instruments; Furniture especially made for laboratories. Scientific and technological services, as well as related research and design services; Industrial analysis and research services; Technological analysis services; Computer aided scientific analysis services.