The present disclosure provides a substance (hatching accelerator) accelerating hatching of cyst nematodes. The hatching accelerator can be advantageously used, for example, to allow cyst nematodes to hatch in soil in the absence of plants on which cyst nematodes are parasitic so as to kill the cyst nematodes by starvation after hatching, thereby preventing crop damage caused by the cyst nematodes.
A01N 37/36 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio-analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
A01M 17/00 - Apparatus for the destruction of vermin in soil or in foodstuffs
A01N 37/42 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing within the same carbon skeleton a carboxylic group or a thio-analogue, or a derivative thereof, and a carbon atom having only two bonds to hetero atoms with at the most one bond to halogen, e.g. keto-carboxylic acids
A01N 37/44 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio-analogue of a carboxylic group, e.g. amino-carboxylic acids
A01N 43/08 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom five-membered rings with oxygen as the ring hetero atom
A01N 45/02 - Biocides, pest repellants or attractants, or plant growth regulators containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring having three carbocyclic rings
The present invention provides a method for analyzing a blood sample. According to the present invention, there is provided, for example, a method for testing or analyzing a blood sample from a subject having cancer or suspected of having cancer, including evaluating taxis behavior of nematodes to the blood sample. According to the present invention, there is provided, for example, a method for evaluating whether a subject has cancer or not by the above method.
A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.
To provide a research result distribution platform that is highly convenient for researchers and people trying to use research results. A research result acquisition unit acquires research result information indicating results of research of researchers. A management unit manages one or more pieces of research result information acquired by the research result acquisition unit, for each researcher. An extraction unit extracts the research result information desired by a user from the one or more pieces of research result information managed by the management unit. A research result presentation unit presents the research result information extracted by the extraction unit to the user. The problem is solved thereby. For both researchers and users, gaining and losing of service points to make the research result distribution platform more active is controlled.
A taxis analysis method for performing taxis analysis of nematodes using a container in which a reference point is provided in the container or a culture medium in the container, the taxis analysis method including steps of: imaging a distribution mode of the nematodes in the container after the nematodes and a specimen of a subject are dropped into the container; detecting a position of an object of the reference point corresponding to the reference point included in the image obtained by imaging; determining an attraction region and a avoidance region on the basis of the position; and executing taxis analysis using objects of the nematodes in the determined attraction region and avoidance region.
The present invention provides a blood sample testing method. The present invention provides, for example, a method for testing or analyzing a blood sample from a subject that has cancer or a subject suspected of having cancer, the method involving evaluating the taxis behavior of a nematode with respect to the blood sample. The present invention thereby provides, for example, a method for evaluating whether a subject has cancer.
A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.
A method of examining for cancer in a non-primate mammal such as a pet animal may include, for example, a method of examining or diagnosing for cancer in a non-primate mammal, including evaluating taxic behavior of nematodes toward a urine sample from a subject mammal.
A taxis analysis method according to the present invention, in which nematode taxis is analyzed using a container provided with a reference point inside the container or in a medium inside the container, comprises: a step for introducing nematodes and a sample from a test subject dropwise into the container, followed by imaging the distribution of the nematodes within the container; a step for detecting the position of a reference point object, corresponding to the reference point, that is included within the image obtained via imaging; a step for determining a region of attraction and an avoided region on the basis of the abovementioned position; and a step for analyzing taxis by using objects of the nematodes in the determined region of attraction and avoided region.
10.
TAXIS ANALYSIS METHOD, CANCER EVALUATION METHOD, TAXIS ANALYSIS SYSTEM, AND PROGRAM
A taxis analysis method according to the present invention, in which nematode taxis is analyzed using a container provided with a reference point inside the container or in a medium inside the container, comprises: a step for introducing nematodes and a sample from a test subject dropwise into the container, followed by imaging the distribution of the nematodes within the container; a step for detecting the position of a reference point object, corresponding to the reference point, that is included within the image obtained via imaging; a step for determining a region of attraction and an avoided region on the basis of the abovementioned position; and a step for analyzing taxis by using objects of the nematodes in the determined region of attraction and avoided region.
The present invention provides a method for predicting a therapeutic effect and/or monitoring recurrence in a cancer patient. Disclosed is a method for detecting a therapeutic effect of cancer treatment in a cancer patient, comprising: measuring nematode tactic behavior to each of pre-treatment urine and in-treatment or post-treatment urine from the cancer patient; and comparing a result of measuring the tactic behavior to the pre-treatment urine and a result of measuring the tactic behavior to the in-treatment or post-treatment urine, wherein when attraction is weakened or avoidance is strengthened after the treatment, it is determined that the therapeutic effect is detected.
To provide a research result distribution platform that is highly convenient for researchers and people trying to use research results. A research result acquisition unit 111 acquires research result information indicating results of research of researchers R. A management unit 102 manages one or more pieces of research result information acquired by the research result acquisition unit 111, for each researcher R. An extraction unit 103 extracts the research result information desired by a user U from the one or more pieces of research result information managed by the management unit 102. A research result presentation unit 141 presents the research result information extracted by the extraction unit 103 to the user U. The problem is solved thereby.
NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY (Japan)
Inventor
Hirotsu, Takaaki
Jono, Hirofumi
Abstract
The present invention provides a method for highly sensitively and highly specifically detecting a kidney cancer. According to the present invention, there is provided, for example, a method for detecting a kidney cancer in a subject, comprising diluting a urine sample obtained from the subject at a predetermined ratio, and determining whether or not nematodes exhibit attraction behavior toward the diluted urine sample, wherein the predetermined ratio is 200 or more.
The present invention provides a method for detecting cancer using a tissue specimen. Specifically, for example, there is provided a method for detecting cancer in an organ or tissue having cancer, comprising: preparing a cell lysate from a region suspected to be cancer isolated from the organ or tissue; and evaluating a tactic behavior of a nematode for the cell lysate.
Provided is a method for examining cancer in a non-primate mammal such as a pet animal. According to the present invention, provided is, for example, a method for examining or diagnosing cancer in a non-primate mammal, said method comprising evaluating taxis behavior of a nematode toward a urine sample of the subject animal.
G01N 33/493 - Physical analysis of biological material of liquid biological material urine
16.
Method for evaluating taxic behavior in response to odor substance based on olfactory sense in nematodes, and dish and behavior evaluation system used in evaluation method
The present invention provides a method for evaluating the taxic behavior of nematodes in response to an odor substance based on olfactory sense, and a dish and a behavior evaluation system to be used for the evaluation method.
[Solution]
Provided is a method for evaluating the taxic behavior of nematodes in response to odor of a test sample, the method including: a) providing a dish in which the test sample is arranged on the bottom surface, and nematodes are arranged in a region or a site of the bottom surface 1 cm to 3 cm away from the test sample; b) observing the arrangement of the nematodes on the bottom surface at 3 to 15 minutes after the later one of the test sample or the nematodes is arranged; and c) evaluating whether the nematodes show attraction behavior or avoidance behavior in response to the test sample, from the arrangement of the nematodes observed, and a dish or a taxic behavior evaluation system suitable for the method.
A cancer analysis system includes, so as to perform an efficient image analysis in a cancer screening test using nematodes: a light source unit that irradiates a plate on which nematodes and a urine sample are plotted, from below; a photographing unit that takes an image of the plate irradiated by the light source unit; and an analyzer that analyzes the image taken by the photographing unit. The analyzer: couples a prescribed number of pixels in the image into a larger number of pixels thereof; and performs a chemotaxis assay of the nematodes based on a time variation of information on a luminous center of gravity of the image.
NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY (Japan)
Inventor
Hirotsu Takaaki
Jono Hirofumi
Abstract
The present invention provides a highly sensitive and highly specific method for detecting kidney cancers. The present invention relates to a method for detecting kidney cancer in a subject and comprises: diluting a urine sample obtained from the subject by a prescribed factor; and evaluating whether a nematode displays attractive chemotaxis towards the diluted urine sample, wherein the prescribed factor is equal to or more than 200.
The present invention provides a cancer detection method that uses a tissue sample. Specifically, the present invention provides a method for detecting cancer in, for example, an organ or tissue that has cancer, the method involving: preparing a cell lysate of a region that has been isolated from the organ or the tissue and is suspected to be cancer; and evaluating the taxic movement of a nematode relative to the cell lysate.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations for use in cancer testing. Cancer testing apparatus. Testing and diagnosis of cancer, and providing information
relating thereto.
21.
Cancer test system and method for assessing cancer test
In order to determine, in a cancer test using nematodes, whether or not the nematodes used in the cancer test are adequate, the present invention is characterized in that after a plate on which a urine from a subject and the nematode are set is placed, a cancer test apparatus performs imaging for quality assay of the nematode during the initial two minutes; an analysis apparatus determines a quality of the nematode using the imaging result; after taxis of the nematode is completed, the cancer test apparatus performs imaging for cancer test assay by the nematode; and the analysis apparatus determines the presence or absence of a cancer in the subject using the imaging result.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
22.
DIAGNOSTIC AGENT FOR CANCER CONTAINING NEMATODE MUTANT, AND METHOD FOR ASSESSING TACTIC BEHAVIOR USING SAID MUTANT
Provided is a method for predicting the therapeutic effect and/or recurrence monitoring of cancer patients. The method detects the therapeutic effect of cancer treatment in cancer patients, and includes assessing the migratory behavior of nematodes with respect to urine of cancer patients before treatment and urine of cancer patients during or after treatment, and comparing assessment results of migratory behavior with respect to urine before treatment with assessment results of migratory behavior with respect to urine during and after treatment. If the attraction behavior after treatment has weakened or if repellent behavior after treatment has strengthened, a therapeutic effect is detected.
The present invention provides a method for predicting a therapeutic effect and/or monitoring recurrence in a cancer patient. Disclosed is a method for detecting a therapeutic effect of cancer treatment in a cancer patient, comprising: measuring nematode taxis behavior to each of pre-treatment urine and in-treatment or post-treatment urine from the cancer patient; and comparing a result of measuring the taxis behavior to the pre-treatment urine and a result of measuring the taxis behavior to the in-treatment or post-treatment urine, wherein when attraction is weakened or avoidance is strengthened after the treatment, it is determined that the therapeutic effect is detected.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations for use in cancer testing Cancer testing apparatus Medical testing and diagnosis of cancer, and providing information relating thereto
28.
METHOD FOR EVALUATING TAXIC BEHAVIOR IN RESPONSE TO ODOR SUBSTANCE BASED ON OLFACTORY SENSE IN NEMATODES, AND DISH AND BEHAVIOR EVALUATION SYSTEM USED IN EVALUATION METHOD
The present invention provides a method for evaluating taxic behavior in response to an odor substance based on the olfactory sense in nematodes, and to a Petri dish and a behavior evaluation system used in the evaluation method. [Solution] The present invention is a method for evaluating taxic behavior in nematodes in response to a test sample odor, wherein the method includes the steps of a) providing a Petri dish in which a test sample is disposed on a bottom surface thereof, a nematode being disposed in a region or position of the bottom surface 1 cm to 3 cm away from the test sample, b) observing the placement of the nematode on the bottom surface 3 to 15 minutes after placement of the test sample or the nematode, whichever was placed last, and c) evaluating, from the observed placement of the nematode, whether an attractive behavior or an evasive behavior with respect to the test sample was exhibited. The present invention is also a Petri dish or a taxic behavior evaluation system suitable for the method.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations for use in cancer testing. Cancer testing apparatus. Testing and diagnosis of cancer, and providing information
relating thereto.
30.
Cancer detection method using sense of smell of nematode
A cancer detection method characterised in that a nematode is bred in the presence of bio-related material originating from a test subject, or a processed product of same, and cancer is detected using the chemotaxis due to the sense of smell of the nematode as an indicator.
