Abstract

A method of removing THC and THCA from a non-decarboxylated hemp extract, the non-decarboxylated hemp extract including THC and THCA and at least one cannabinoid is provided. The method comprises passing a first feedstock stream through a first chromatographic resin arranged in a simulated moving bed (SMB) chromatography configuration to provide a primary raffinate stream, preparing a second feedstock stream, the second feedstock stream comprising the primary raffinate stream or a concentrated primary raffinate stream, and passing the second feedstock stream through a second chromatographic resin to provide an eluate stream, the eluate stream having less than 0.1 wt % THC on a solvent free basis. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

IPC Classes  ?

• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
• B01J 20/26 - Synthetic macromolecular compounds
• A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline

Abstract

A method of removing THC and/or THCA from a mixture is provided, the mixture including at least one other cannabinoid. The method comprises passing a first feedstock stream through a first chromatographic resin arranged in a simulated moving bed (SMB) chromatography configuration to provide a primary raffinate stream, preparing a second feedstock stream, the second feedstock stream comprising the primary raffinate stream or a concentrated primary raffinate stream, and passing the second feedstock stream through a second chromatographic resin to provide an eluate stream, the eluate stream having less than 0.3 wt % THC on a solvent free basis. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

IPC Classes  ?

• C07D 311/78 - Ring systems having three or more relevant rings
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• C07C 37/82 - SeparationPurificationStabilisationUse of additives by physical treatment by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by physical treatment by chemisorption
• C07C 37/84 - SeparationPurificationStabilisationUse of additives by physical treatment by crystallisation

Abstract

cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

IPC Classes  ?

• C07C 37/84 - SeparationPurificationStabilisationUse of additives by physical treatment by crystallisation
• C07C 51/42 - SeparationPurificationStabilisationUse of additives
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• C07C 37/68 - SeparationPurificationStabilisationUse of additives
• C07C 37/82 - SeparationPurificationStabilisationUse of additives by physical treatment by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by physical treatment by chemisorption
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/05 - Phenols
• B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
• C07C 39/23 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
• C07C 65/19 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring

Abstract

cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

IPC Classes  ?

• C07C 37/00 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
• C07C 51/00 - Preparation of carboxylic acids or their salts, halides, or anhydrides
• B01D 15/00 - Separating processes involving the treatment of liquids with solid sorbentsApparatus therefor
• C07C 37/68 - SeparationPurificationStabilisationUse of additives
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• C07C 37/84 - SeparationPurificationStabilisationUse of additives by physical treatment by crystallisation
• C07C 37/82 - SeparationPurificationStabilisationUse of additives by physical treatment by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by physical treatment by chemisorption
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/05 - Phenols
• C07C 51/42 - SeparationPurificationStabilisationUse of additives
• B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
• C07C 39/23 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
• C07C 65/19 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring

Goods & Services

natural agriculture products containing compounds derived from industrial hemp, namely, non-medicated topical cosmetic preparations; all of the foregoing containing ingredients solely derived from hemp with a delta-9 tetrahydrocannabinol (THC) concentration of not more than 0.3 percent on a dry weight basis

Goods & Services

Botanical extracts from industrial hemp used as an ingredient in the manufacture of non-medicated topical cosmetics and cosmetic toiletries; all of the foregoing containing ingredients solely derived from hemp with a delta-9 tetrahydrocannabinol (THC) concentration of not more than 0.3 percent on a dry weight basis

Goods & Services

Botanical extracts from industrial hemp used as an ingredient in the manufacture of non-medicated topical cosmetics and cosmetic toiletries; all of the foregoing containing CBD solely derived from hemp with a delta-9 tetrahydrocannabinol (THC) concentration of not more than 0.3 percent on a dry weight basis

Goods & Services

Plant extracts containing compounds derived solely from industrial hemp for use in the manufacture of non-medicated topical cosmetic preparations, containing hemp-derived CBD; all of the foregoing derived solely from hemp with a delta-9 tetrahydrocannabinol (THC) concentration of not more than 0.3 percent on a dry weight basis

Goods & Services

Botanical extracts from industrial hemp used as an ingredient in the manufacture of non-medicated topical cosmetics and cosmetic toiletries; all of the foregoing containing CBD solely derived from hemp with a delta-9 tetrahydrocannabinol (THC) concentration of not more than 0.3 percent on a dry weight basis of not more than 0.3 percent on a dry weight basis

Goods & Services

Botanical extracts from industrial hemp, with a delta-9 tetrahydrocannabinol (THC) concentration of not more than 0.3 percent on a dry weight basis, used as an ingredient in the manufacture of non-medicated topical cosmetics and cosmetic toiletries; all of the foregoing containing CBD solely derived from hemp with a delta-9 tetrahydrocannabinol (THC) concentration of not more than 0.3 percent on a dry weight basis

Abstract

cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

IPC Classes  ?

• C07C 51/42 - SeparationPurificationStabilisationUse of additives
• C07C 37/00 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
• B01D 15/00 - Separating processes involving the treatment of liquids with solid sorbentsApparatus therefor
• C07C 37/68 - SeparationPurificationStabilisationUse of additives
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• C07C 37/84 - SeparationPurificationStabilisationUse of additives by physical treatment by crystallisation
• C07C 37/82 - SeparationPurificationStabilisationUse of additives by physical treatment by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by physical treatment by chemisorption
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/05 - Phenols
• B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
• C07C 39/23 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
• C07C 65/19 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring

Abstract

cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

IPC Classes  ?

• C07C 37/00 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
• B01D 15/00 - Separating processes involving the treatment of liquids with solid sorbentsApparatus therefor
• C07C 37/68 - SeparationPurificationStabilisationUse of additives
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• C07C 37/84 - SeparationPurificationStabilisationUse of additives by physical treatment by crystallisation
• C07C 37/82 - SeparationPurificationStabilisationUse of additives by physical treatment by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by physical treatment by chemisorption
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/05 - Phenols
• C07C 51/42 - SeparationPurificationStabilisationUse of additives
• B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
• C07C 39/23 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
• C07C 65/19 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring

Abstract

cannabis materials and extracts, while removing undesirable naturally occurring components that may be present including colorants, carbohydrates, sugars and waxes, and the like, as well as contaminants that may be present in source materials including bactericides, fungicides, insecticides, plant growth regulators, environmental pollutants, and processing aids, and the like. The present invention further relates to an isolate obtained using a series of extraction and isolation processes that has extremely high cannabinoid content present in a stable, flowable liquid form that is essentially free of detectable levels of psychoactive cannabinol components.

IPC Classes  ?

• A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
• A61K 36/185 - Magnoliopsida (dicotyledons)