The present disclosure relates to the synthesis of Vitamin K2 bearing varying prenyl side chains. The synthesis comprises the reaction of phenyl sulfone of tert-butyl dimethyl silyl (TBDMS) protected mono prenyl menadiol with prenyl halides bearing varying prenyl units in the presence of the phase transfer catalyst followed by reductive desulphonation to yield TBDMS ether of Vitamin K2. The TBDMS ether is then oxidized in the presence of chromium trioxide and periodic acid to yield the corresponding Vitamin K2.
The present invention relates to novel animal feed supplements that comprise menaquinone-n, wherein (n) is the number of repeating 5 carbon units. The supplements further comprise saccharides, carotenoids, xanthophylls, minerals and electrolytes. The animal feed supplement comprises menaquinone-n, wherein (n) is the number of repeating 5 carbon units, enhances and the growth, reduces the mortality, and improves the feed conversion ratio, improves liver and bone health, and replaces the need for use of probiotics in livestock and/or poultry, especially monogastric livestock and/or poultry receiving such animal feed supplements.
C07C 50/14 - Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
3.
Process for stereospecific synthesis of vitamin K2 and its novel intermediates
The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7. The present disclosure further discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.
The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7, in particular. It also discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.
C07C 50/14 - Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
C07C 41/18 - Preparation of ethers by reactions not forming ether-oxygen bonds
C07C 50/28 - Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Nutraceuticals for use as a dietary supplement for general health and well-being; nutraceuticals for use as a dietary supplement for supplementation as a food ingredient for general health and well-being.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Bacterial preparations for the food industry; probiotic
bacteria for the food industry (in food supplement);
probiotic bacterial cultures for the food industry; chemical
additives for use in the manufacture of food; antioxidants
for use in the manufacture of food supplements.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Bacterial preparations for the food industry; probiotic
bacteria for the food industry (in food supplement);
probiotic bacterial cultures for the food industry; chemical
additives for use in the manufacture of food; antioxidants
for use in the manufacture of food supplements.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
(1) Bacterial preparations for the food industry; probiotic bacteria for the food industry (in food supplement); probiotic bacterial cultures for the food industry; chemical additives for use in the manufacture of food; antioxidants for use in the manufacture of food supplements.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Bacteria for use in food manufacture; Bacterial preparations for the food industry; Probiotic compositions for use as ingredients for food and beverages, namely, probiotic bacteria and probiotic bacterial cultures for use in the manufacture of food supplements; Chemical additives for use in the manufacture of food; Antioxidants for use in the manufacture of food supplements; Antioxidants for use in the manufacture of pharmaceuticals
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Bacteria for use in food manufacture; Bacterial preparations for the food industry; Probiotic compositions for use as ingredients for food and beverages, namely, probiotic bacteria and probiotic bacterial cultures for use in the manufacture of food supplements; Chemical additives for use in the manufacture of food; Antioxidants for use in the manufacture of food supplements; Antioxidants for use in the manufacture of pharmaceuticals
15.
Vitamin K2 compositions for the treatment of drug induced neuropathy
The present invention provides the use of vitamin K2 compositions for the treatment of drug-induced neuropathy. More particularly it is related to the use of vitamin K2-7 compositions for the treatment of drug-induced peripheral neuropathy caused by the drugs used for the treatment of multiple myeloma.
A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
The present invention provides the use of vitamin K2 compositions for the treatment of drug- induced neuropathy. More particularly it is related to the use of vitamin K2-7 compositions for the treatment of drug- induced peripheral neuropathy caused by the drugs used for the treatment of multiple myeloma.
C07C 50/14 - Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
The present invention provides a stable liquid syrup composition compositions comprising probiotic bacteria, retaining their cellular viability at ambient storage conditions for at least two years.
The present invention provides a stable liquid syrup composition compositions comprising probiotic bacteria, retaining their cellular viability at ambient storage conditions for at least two years.
A23C 9/123 - Fermented milk preparationsTreatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceaeYoghurt
A23C 9/127 - Fermented milk preparationsTreatment using microorganisms or enzymes using microorganisms of the genus lactobacteriaceae and other microorganisms or enzymes, e.g. kefir, koumiss
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Animal feed additive for use as a nutritional supplement for medical purposes; Animal feed supplements; Bee pollen for use as a dietary food supplement; Biscuits, bread, bread rolls, cakes, cereal products, confectionery, crackers, noodles, fish sauce, relish, sauces, cereal-based snack-foods and prepared dietary items that are gluten-free to accommodate special medical and health conditions; Calcium supplements; Dietary and nutritional supplements; Dietary and nutritionally fortified food products adapted for medical use; Dietary drink mix for use as a meal replacement; Dietary fiber as an additive for food products; Dietary food supplements; Dietary supplemental drinks; Dietary supplements; Dietary supplements for animals; Dietary supplements for human consumption; Dietary supplements for pets; Feed supplements for dogs; Fish, pickles, preserved olives and dietary foods and food-items that are gluten-free to accommodate special medical and health conditions; Food supplements; Food supplements, namely, anti-oxidants; Ground flaxseed fiber for use as a dietary supplement; Herbal supplements; Homeopathic supplements; Lecithin for use as a dietary supplement; Meal replacement and dietary supplement drink mixes; Mineral food supplements; Mineral nutritional supplements; Mineral supplements; Non-medicated additives for animal feed for use as nutritional supplements; Nutraceuticals for use as a dietary supplement; Nutritional additives for medical purposes for use in foods and dietary supplements for human consumption; Nutritional supplements; Nutritional supplements in lotion form sold as a component of nutritional skin care products; Powdered fruit-flavored dietary supplement drink mix; Powdered nutritional supplement drink mix; Vitamin and mineral supplements; Vitamin supplement in tablet form for use in making an effervescent beverage when added to water; Vitamin supplements; Vitamins and dietary food supplements for animals; Wheat for use as a dietary supplement
