Abstract

A method of identifying one or more bacteria from a sample, where the one or more bacteria is suspected to be present in the sample. An aqueous suspension including a bacteria-SERS nanoparticle complex is provided, where the bacteria-SERS nanoparticle complex includes (i) a SERS nanoparticle and (ii) the one or more bacteria suspected to be present in the sample. Furthermore, the aqueous suspension is deposited on a substrate having structures coated with a SERS-active material to dispose the bacteria-SERS nanoparticle complex on the substrate. Additionally, the bacteria-SERS nanoparticle complex disposed on the substrate is irradiated to generate one or more SERS signals. Furthermore, a SERS-spectroscopic module is operable to render one or more SERS spectral data corresponding to the one or more SERS signals. Additionally, a process module is operable to identify the presence or absence of the one or more bacteria from the one or more SERS spectral data.

IPC Classes  ?

• G01N 21/65 - Raman scattering
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G16B 40/20 - Supervised data analysis
• G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks

Abstract

There is provided a compound comprising a structure represented by general formula (1) or an ionized form thereof for preparing lipid nanoparticles encapsulating a therapeutic, prophylactic and/or biological agent wherein R3is optionally substituted alkylene, optionally substituted alkenylene, or optionally substituted alkynylene; R1, R2, R10, and R11are each independently optionally substituted alkylene, optionally substituted alkenylene, optionally substituted alkynylene, or a single bond; R4, R5, R6, R7, R8, and R91249122 are not H at the same time; B1, B2, B3, and B4are each independently -H, -ORa, -NRaRb, -SRa, - C(ORa)(Rb)(Rc), -C(SRa)(Rb)(Rc), or -C(NRaRb)(Rc)(Rd), where each of Ra, Rb, Rc, and Rd is independently H, optionally substituted alkyl, optionally substituted alkenyl, or optionally substituted alkynyl; w ≥ 0; x ≥ 1; and y ≥ 1.

IPC Classes  ?

• C07C 271/20 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
• A61K 9/14 - Particulate form, e.g. powders
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

Abstract

The present invention relates generally to the field of molecular biology. In particular, the specification teaches methods of preventing or treating an RNA viral infection in a subject.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 35/76 - VirusesSubviral particlesBacteriophages
• A61P 31/14 - Antivirals for RNA viruses

Abstract

There is provided a lens for use in a human or animal body, the lens comprising a metasurface configured to modulate incident light, wherein the metasurface is composed of at least one light transmissive biomaterial. Also provided is a method of making the lens.

IPC Classes  ?

• A61F 2/16 - Intraocular lenses
• G02C 7/02 - LensesLens systems

Abstract

The present invention relates to use of expression vectors and other compounds in methods to disrupt the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, uncoupling the nucleus from its linkage to the cytoskeleton, resulting in amelioration of diseases caused by one or more Lmna mutations, so-called laminopathies. More particularly, the invention relates to the expression of dominant negative SUN domain protein and/or dominant negative KASH domain protein to disrupt, for example, the LINC complex in cardiomyocytes for suppressing disease progression in dilated cardiomyopathy (DCM).

IPC Classes  ?

• C12N 15/86 - Viral vectors
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

There is provided a method of encapsulating cells, a porous scaffold structure, and a cell culture system, the method comprising, (i) dispersing a population of cells from one or more strains in a precursor solution, (ii) forming a hydrogel matrix from the precursor solution, (iii) reducing the hydrogel matrix into a plurality of hydrogel microparticles, said hydrogel microparticles comprising cells encapsulated therein, and (iv) crosslinking the plurality of hydrogel microparticles to form a porous scaffold structure comprising a network of pores formed between the plurality of hydrogel microparticles.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 11/04 - Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
• C12P 1/04 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes by using bacteria
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12R 1/19 - Escherichia coli

Abstract

Disclosed is a method of pre-processing and inferencing data for RNA chemical modification detection. The method employs direct RNA sequencing on synthetic RNA sequences, various outputs. Basecalled RNA reads are aligned to reference synthetic RNA sequences to obtain sequence alignment reads. Nucleotide assignments of the sequence alignment reads are then refined, data segmented and the segmented data aligned to the individual k-mers. Raw signal features corresponding to specific nucleotide positions in the reference synthetic RNA sequence are then identifiable. The features of the raw signals are subjected to a multiple-instance supervised learning model training framework for the detection of one RNA chemical modification or multiple RNA chemical modifications. The trained model infers from an unseen RNA sequence data set the likelihood of one RNA chemical modification or multiple RNA chemical modifications.

IPC Classes  ?

• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• G16B 40/20 - Supervised data analysis
• C12Q 1/6869 - Methods for sequencing

Abstract

This disclosure concerns methods of analysing and sequencing viral genomic DNA, in particular Epstein-Barr virus (EBV) genomic DNA, using viral-specific nucleic acid capture probes and long read sequencing.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention relates, in general terms, to antigen-binding molecules. In particular, the present disclosure relates to antigen-binding molecules that specifically bind to CEACAM1, CEACAM5 and CEACAM6.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 40/31 - Chimeric antigen receptors [CAR]
• G01N 33/577 - ImmunoassayBiospecific binding assayMaterials therefor involving monoclonal antibodies
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 35/00 - Antineoplastic agents

Abstract

The present disclosure provides a modified adeno-associated virus 1 (AAV1) comprising an AAV1 VP3 capsid protein, wherein the AAV1 VP3 capsid protein comprises one or more mutations at a position selected from the group consisting of: S507, and S587, relative to a wild-type AAV1 capsid protein sequence of SEQ ID NO: 65. The present disclosure also provides capsid proteins, nucleic acids, and compositions comprising said modified AAV1. The present disclosure also provides a method of treating a corneal disease to a subject, wherein the method comprises administering a therapeutically effective amount of the modified AAV1, or the composition of the disclosure to a subject, wherein the modified AAV1 comprises a payload for treating a corneal disease. Also provided by the present disclosure is a method of delivering a payload to a cornea of a subject, comprising administering the modified adeno-associated virus 1 (AAV1), or the composition of the disclosure, to the cornea of the subject.

IPC Classes  ?

• C07K 14/015 - Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
• C12N 15/864 - Parvoviral vectors
• A61K 35/76 - VirusesSubviral particlesBacteriophages
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 27/02 - Ophthalmic agents
• C12R 1/93 - Animal viruses

Abstract

There is provided a ribozyme comprising: a) one or more catalytic domains capable of switching between an active state and an inactive state; b) one or more releasable RNA segments, wherein each of said releasable RNA segments is flanked by two ribozyme cleavage sites, wherein cleavage at each cleavage site is catalysed by at least one of the one or more catalytic domains in an active state; c) one or more trigger-binding domains, each of which is for the binding of a trigger nucleic acid molecule; wherein each of the one or more catalytic domains is linked to one of the one or more trigger-binding domains; wherein the catalytic domain is in an inactive state when the trigger-binding domain linked to said catalytic domain is not bound by the trigger nucleic acid molecule, and wherein the catalytic domain is in an active state when the trigger-binding domain linked to said catalytic domain is bound by the trigger nucleic acid molecule; and wherein when both cleavage sites flanking a releasable RNA segment are cleaved when catalysed by the one or more catalytic domains, the one or more releasable RNA segment is released from the ribozyme. Also disclosed are methods of detecting presence of a trigger nucleic acid molecule in a sample, methods of detecting presence of a sequence or mutation of interest on an nucleic acid of interest in a sample, and kits comprising the ribozymes thereof.

IPC Classes  ?

• C12Q 1/6823 - Release of bound markers
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates generally to the field of RNA splicing. In particular, the invention relates to splice-switching oligonucleotides (SSOs) capable of altering the splicing of a pre-mRNA encoding a variant of the SLC25A13 gene. The invention also relates to the use of SSOs as therapeutic candidates for treating citrin deficiency. In an aspect of the invention, there is provided a method of exon-skipping comprising providing a splice-switching oligonucleotide (SSO) that binds to a site within a target region present on a pre-mRNA transcript of the SLC25A13 gene, wherein the binding of the SSO induces the exclusion of SLC25A13-PE5 from a mature mRNA transcript of the SLC25A13 gene. In another aspect, there is provided a splice-switching oligonucleotide (SSO) that binds to a site within a target region present on a pre-mRNA transcript of the SLC25A13 gene, the target region having at least 95% sequence identity to SEQ ID NO: 28, and wherein binding of the SSO induces the exclusion of SLC25A13-PE5 from a mature mRNA transcript of the SLC25A13 gene.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present disclosure concerns a microfluidic method of assaying antibody secreting cells (ASCs), comprising the steps of isolating ASCs within droplets such that each droplet encapsulates only one ASC; incubating the droplets of step a) to accumulate antibodies within the droplets; picoinjecting virus into the droplets of step b) to form immune complex droplets; picoinjecting host cells into the immune complex droplets to form neutralised droplets and infected droplets; and sorting the infected droplets from the neutralised droplets, b based on infection of the host cells by the virus, to assay the ASCs within the neutralised droplets. The present disclosure also concerns a microfluidic platform thereof.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 33/536 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase

Abstract

The present invention provides a method of detecting non-host species in a host sample. The host sample is contacted with magnetic particles coupled to enzymes to degrade cell-free host nucleic acids present in the host sample, wherein the magnetic particles coupled to enzymes are capable of degrading both DNA and RNA. A magnetic field is applied to remove the magnetic particles coupled to enzymes from the host sample. A DNA and RNA library is created from the degraded sample in a one-pot process, followed by detection of the presence of non-host nucleic acids from the DNA and RNA library.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

Various embodiments may relate to a stacked arrangement. The stacked arrangement may include a silicon carbide (SiC) layer or substrate. The stacked arrangement may also include a metal-based layer or stack. The stacked arrangement may further include a conductive metal oxide layer between the silicon carbide layer or substrate and the metal-based layer or stack, the conductive metal oxide layer configured to allow diffusion of metal from the metal-based layer or stack through the conductive metal oxide layer. The stacked arrangement may also include a metal silicide layer between the silicon carbide layer or substrate and the conductive metal oxide layer.

IPC Classes  ?

• H01L 21/04 - Manufacture or treatment of semiconductor devices or of parts thereof the devices having potential barriers, e.g. a PN junction, depletion layer or carrier concentration layer
• H01L 21/28 - Manufacture of electrodes on semiconductor bodies using processes or apparatus not provided for in groups
• H10D 62/10 - Shapes, relative sizes or dispositions of the regions of the semiconductor bodiesShapes of the semiconductor bodies

Abstract

In some embodiments, a method for depositing epitaxy films is provided. The method includes: (a) depositing a first buffer layer on a substrate at a first temperature; (b) conducting a growth interruption at a second temperature for a period of time, the second temperature being less than the first temperature; and (c) depositing a second buffer layer on the first buffer layer at a third temperature.

IPC Classes  ?

• C30B 25/18 - Epitaxial-layer growth characterised by the substrate
• C30B 29/40 - AIIIBV compounds
• H10D 62/832 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group IV materials, e.g. B-doped Si or undoped Ge being Group IV materials comprising two or more elements, e.g. SiGe

Abstract

The present invention relates to methods of engineering and identifying a peptide aptamer that binds to a target protein of interest, and peptide aptamers engineered and identified using these methods and methods to identify a candidate peptide or nucleic acid that binds to a target protein in a live cell. The peptide aptamers defined herein may be useful for treating a condition associated with dysregulated cap-dependent translation, dysregulated DNA replication, dysregulated DNA repair and/or dysregulated mRNA translation such as cancer, diseases associated with a viral infection and obesity.

IPC Classes  ?

• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61P 35/00 - Antineoplastic agents

Abstract

A method of forming a titania-coated inorganic particle comprising the steps of (a) stirring a mixture of a titania precursor such as a titanium alkoxide and an inorganic particle such as a hollow glass particles in an organic solvent such as an alcohol for more than 1 h to cause adsorption of the titania precursor on the surface of the inorganic particle; and (b) adding water dropwise to the mixture under stirring to convert the titania precursor to titania which then forms a coating on the inorganic particle. A method for forming a paint formulation, a titania-coated inorganic particle, a paint formulation comprising a titania-coated inorganic particle and use of a titania-coated inorganic particle in a paint formulation is also described.

IPC Classes  ?

• C09C 3/06 - Treatment with inorganic compounds
• C08K 3/22 - OxidesHydroxides of metals
• C08K 3/34 - Silicon-containing compounds
• C08K 3/36 - Silica
• C08K 3/40 - Glass
• C08K 7/20 - Glass
• C08K 7/26 - Silicon-containing compounds
• C08K 7/28 - Glass
• C08K 9/02 - Ingredients treated with inorganic substances
• C09C 1/28 - Compounds of silicon
• C09D 5/33 - Radiation-reflecting paints
• C09D 7/40 - Additives
• C09D 7/62 - Additives non-macromolecular inorganic modified by treatment with other compounds

Abstract

Provided herein are hepatic glucose production (HGP) assay methods which measure changes in total HGP, HGP due to glycogenolysis, and/or HGP due to gluconeogenesis, in response to a compound. Also provided herein are HGP assay methods which identify hepatic cells that are responsive to compounds by measuring changes in total HGP, HGP due to glycogenolysis, and/or HGP due to gluconeogenesis. Further provided herein are kits of reagents suitable for preparation of samples for in vitro measurement of HGP.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The present disclosure concerns branched-chain ketoacid dehydrogenase kinase modulators and methods thereof.

IPC Classes  ?

• A61K 31/415 - 1,2-Diazoles
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 35/00 - Antineoplastic agents
• C07D 255/02 - Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups not condensed with other rings
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 403/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 471/04 - Ortho-condensed systems
• C07D 513/04 - Ortho-condensed systems

Abstract

An apparatus for resin three-dimensional (3D) printing of a fluidic device having a channel therein, the apparatus comprising: at least one through hole provided in a build plate of a resin 3D printer, wherein the through hole is provided in alignment and fluid connection with a port of the channel, wherein the port is one of: an inlet and an outlet of the channel; and a fluid reservoir provided in fluid connection with the through hole; wherein activation of the fluid reservoir removes uncured resin from the channel after a newly crosslinked layer of resin has been formed on the fluidic device being printed on the build plate by the resin 3D printer. 3(a)

IPC Classes  ?

• B29C 64/245 - Platforms or substrates
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B33Y 10/00 - Processes of additive manufacturing

Abstract

The present invention relates to a method comprising the detection of LOC105375914 RNA in a glioma sample obtained from a subject, wherein an elevated level of LOC105375914 RNA as compared to a reference indicates that the subject has a high grade glioma, has a likelihood of resistance to chemotherapy, has a likelihood of recurrence, and/or is likely to have a poor prognosis. The present invention also relates to a method of treating a glioma expressing LOC105375914 RNA in a subject by administering an inhibitor of the LOC-DEAH-box helicase 15 (DHX15) complex to the subject.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

There is provided a thermogel-drug composition comprising: a thermogel polymer comprising one or more repeating units derived from a hydrophilic polymer, one or more repeating units derived from a thermoresponsive polymer, and one or more repeating units derived from a vinyl-containing diol monomer; and a drug or a drug analog encapsulated by said thermogel polymer.

IPC Classes  ?

• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 9/06 - OintmentsBases therefor
• C08G 18/48 - Polyethers
• C08G 18/32 - Polyhydroxy compoundsPolyaminesHydroxy amines
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08J 3/075 - Macromolecular gels
• C08G 85/00 - General processes for preparing compounds provided for in this subclass

Abstract

The invention relates to recombinant mutated angiotensin converting enzyme 2 (ACE2) comprising one or more amino acid substitutions at amino acid positions T27, F28, K31, H34, Y41 and Q42 which have improved binding affinity to SARS-CoV-1 and/or SARS-CoV-2. It also relates to combinatorial mutant ACE2 comprising T27Y/K31 H/H34A, T27YZ K31 H/H134V and T27Y/K31 Y/H134V and the use of said mutant ACE2 for treating and preventing coronavirus infection.

IPC Classes  ?

• C12N 9/48 - Hydrolases (3.) acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present invention relates to the use of mitoxantrone hydrochloride as a therapeutic drug for the treatment of neurodegenerative disorder in a subject, wherein the mitoxantrone hydrochloride is an inhibitor of β-amyloid precursor protein (APP) and leucine-rich repeat kinase 2 (LRRK2), capable of inhibiting APP and LRRK2 protein levels in the subject.

IPC Classes  ?

• A61K 31/136 - Amines, e.g. amantadine having aromatic rings, e.g. methadone having the amino group directly attached to the aromatic ring, e.g. benzeneamine
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/16 - Anti-Parkinson drugs

Abstract

This document relates to a computing module that is configured to generate a cognitive score for a user. The score is determined by a trained machine learning model, which is configured to process inputs generated by the user as the user completes a plurality of digital tasks that are accessible through a graphical user interface module communicatively connected to the computing module. The machine learning model used in the computing module was trained based on training data that had been validated with corresponding near-infrared spectroscopy (fNIRS) data.

IPC Classes  ?

• A61H 5/00 - Exercisers for the eyes
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G09B 7/02 - Electrically-operated teaching apparatus or devices working with questions and answers of the type wherein the student is expected to construct an answer to the question which is presented or wherein the machine gives an answer to the question presented by the student
• G09B 5/02 - Electrically-operated educational appliances with visual presentation of the material to be studied, e.g. using film strip
• G09B 19/04 - Speaking
• G06N 20/00 - Machine learning

Abstract

The present disclosure provides a Chinese Hamster Ovary (CHO) cell comprising one or more exogenous nucleotide sequences, wherein the one or more exogenous nucleotide sequences is inserted into a chromosomal locus of the CHO cell, wherein the chromosomal locus is located within contig NW_023276805.1 of chromosome X. Also provided herein are methods of producing a CHO cell capable of expressing a sequence of interest, methods of expressing a sequence of interest comprising culturing the CHO cell as described herein, and kits comprising the CHO cell as described herein.

IPC Classes  ?

• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

Described herein are compositions containing branched polyethylenimine and polypropylene glycol covalently bonded to the branched polyethyleneimine, where a molar ratio of the propylene glycol to the branched polyethylenimine is more than 3.35:1, and the polypropylene glycol is hydrophobic. The compositions may be used as a hydrogel and changes between a solution phase and a gel phase by changes in pH or temperature.

IPC Classes  ?

• C08G 73/02 - Polyamines

Abstract

A polymer electrolyte, method of forming, and method of upcycling the same There is provided a polymer electrolyte comprising a graft copolymer and an alkali metal non-coordinating salt, wherein the graft copolymer comprises a polyolefin backbone and polyester grafts. There is also provided a method of preparing the polymer electrolyte, and a method of upcycling the polymer electrolyte.

IPC Classes  ?

• C08F 255/02 - Macromolecular compounds obtained by polymerising monomers on to polymers of hydrocarbons as defined in group on to polymers of olefins having two or three carbon atoms
• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
• H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material

Abstract

This disclosure concerns wild-type and engineered D-Ala-D-Ala ligases (Ddls) and their use for synthesising mycosporine-like amino acids (MAAs), such as MAAs derived from a mycosporine-glutamine backbone and MAAs with hydrophobic side groups. Also disclosed are compositions and uses of the synthesised MAAs.

IPC Classes  ?

• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C07C 251/20 - Compounds containing nitrogen atoms doubly- bound to a carbon skeleton containing imino groups having carbon atoms of imino groups being part of rings other than six-membered aromatic rings
• C07C 249/02 - Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
• C12P 13/04 - Alpha- or beta-amino acids
• A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
• A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations

Abstract

An apparatus and method for correcting errors in transcribed voice commands, wherein the method comprises: receiving a voice command transcript; running a trained joint intent classification and slot filling model to generate contextualized word features and/or embeddings from word sequences detected in the transcript and subject them to intent classification and slot filling to generate predicted intent and slot value; running a trained phonetic based phrase confusion-aware model for correcting a transcription error in the predicted slot value; comparing the predicted slot value and/or an encoding or embedding generated from the predicted slot value against a plurality of predetermined valid slot values and/or a plurality of predetermined encodings or embeddings; and determining phonetic similarity scores for the predicted slot value against each valid slot value; and replacing the predicted slot value containing the transcription error with the valid slot value with highest phonetic similarity score.

IPC Classes  ?

• G06F 40/279 - Recognition of textual entities
• G06F 40/30 - Semantic analysis
• G10L 15/26 - Speech to text systems
• G06N 20/00 - Machine learning

Abstract

The present disclosure relates to methods of producing fatty alcohols, comprising oxidizing a polyolefin in the presence of an iron (II) catalyst and a peroxide initiator to form at least one dicarboxylic acid; and hydrogenating the at least one dicarboxylic acid in the presence of a metal catalyst in order to form the fatty alcohol. The present disclosure also relates to a fatty alcohol composition.

IPC Classes  ?

• C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material
• C07C 29/132 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group
• C07C 31/125 - Monohydroxylic acyclic alcohols containing five to twenty-two carbon atoms
• C07C 51/285 - Preparation of carboxylic acids or their salts, halides, or anhydrides by oxidation with peroxy-compounds
• C07C 55/02 - Dicarboxylic acids

Abstract

A method of radar sensing for detecting multiple targets is provided. The method includes: determining a channel estimation or a cyclic correlation based on a received signal and a transmitted signal, whereby the received signal is reflected from multiple targets from the transmitted signal and the cyclic correlation is determined based on a correlation intermediate term; determining a range-Doppler map based on the channel estimation or the cyclic correlation; and detecting a dominant target amongst the multiple targets based on the range-Doppler map determined based on the channel estimation or the cyclic correlation. In particular, the method further includes, for each iteration of a plurality of iterations: determining a first dominant target attributed channel estimation or a first dominant target attributed correlation intermediate term based on the detected dominant target; modifying the channel estimation or the cyclic correlation including offsetting the first dominant target attributed channel estimation from the channel estimation or offsetting the first dominant target attributed correlation intermediate term from the correlation intermediate term; determining a range-Doppler map based on the modified channel estimation or the modified cyclic correlation; and detecting a next dominant target amongst the multiple targets based on the range-Doppler map determined based on the modified channel estimation or the modified cyclic correlation. There is also provided a corresponding system for radar sensing and a corresponding radar for detecting multiple targets.

IPC Classes  ?

• G01S 7/292 - Extracting wanted echo-signals
• G01S 13/88 - Radar or analogous systems, specially adapted for specific applications
• G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
• G01S 13/02 - Systems using reflection of radio waves, e.g. primary radar systemsAnalogous systems

Abstract

A method of multistage resource scheduling is provided. The method includes: determining, at a first stage, a first stage resource schedule across a first stage scheduling horizon, including a series of timesteps, for a plurality of resource parameters based on a first optimization function; and determining, at a second stage, a second stage resource schedule across a second stage scheduling horizon, including a series of timesteps, for the plurality of resource parameters based on a second optimization function, including, for each timestep, in turn, of the series of timesteps of the second stage scheduling horizon: determining a resource schedule across a prediction horizon with respect to the timestep, including a subseries of timesteps, starting with the timestep, of the series of timesteps of the second stage scheduling horizon, for the plurality of resource parameters based on the second optimization function; and storing values of the resource schedule determined for the plurality of resource parameters for a beginning timestep of the subseries of timesteps as determined values for the plurality of resource parameters for the timestep of the series of timesteps of the second stage scheduling horizon. In particular, for each of one or more timesteps or each of one or more intervals of timesteps of the series of timesteps of the second stage scheduling horizon, respectively, the method further includes determining and setting a length of the prediction horizon for the above-mentioned determining the resource schedule across the prediction horizon. There is also provided a corresponding system for multistage resource scheduling.

IPC Classes  ?

• G06F 17/11 - Complex mathematical operations for solving equations
• G06N 20/00 - Machine learning

Abstract

There is provided a coating formulation comprising an inorganic oxygen scavenger, a surfactant, an activator, a hydrophilic agent, optionally an additive and a plurality of monomers capable of forming a polymeric matrix, and a method to prepare the same. There is also provided an article comprising an inorganic scavenger, a surfactant, an activator, a hydrophilic agent and optionally an additive dispersed within a polymeric matrix, and a method to prepare the same.

IPC Classes  ?

• B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
• A23B 2/717 - Oxygen absorbent
• B01J 20/12 - Naturally occurring clays or bleaching earth
• B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
• B01J 20/26 - Synthetic macromolecular compounds
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/30 - Processes for preparing, regenerating or reactivating
• B65D 65/42 - Applications of coated or impregnated materials
• B65D 81/26 - Adaptations for preventing deterioration or decay of contentsApplications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, fluids, e.g. exuded by contentsApplications of corrosion inhibitors or desiccators

Abstract

422. In certain non-limiting embodiments, the methods may involve one or more of the following steps, such as treating the first leachate with a sodium salt to form a second residue comprising the rare earth metal; treating the first residue with a base to form a second leachate and a second residue, wherein the second leachate comprises silicon, and wherein the second residue comprises mullite; treating the second leachate with gaseous carbon dioxide to form a carbonate-containing base and silicon dioxide; mixing the sodium salt, after treating the first leachate with the sodium salt, with the base to form carbon dioxide and an alumina-containing residue; and recycling the carbon dioxide as the gaseous carbon dioxide for treating the second leachate to form the carbonate-containing base and the silicon dioxide.

IPC Classes  ?

• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• C22B 3/20 - Treatment or purification of solutions, e.g. obtained by leaching
• C22B 21/00 - Obtaining aluminium
• C22B 59/00 - Obtaining rare earth metals

Abstract

This disclosure describes a module and method for configuring a generative adversarial network-based continual oversampling (GAN-COS) module to augment a training dataset. The augmented training dataset may be used to train a classifier module to detect defects in a dataset. During the configuration of the GAN-COS module, datapoints associated with tasks in a training dataset are balanced using a data balancing module before the balanced dataset is then processed by a shared generator and a private generator of the GAN-COS module. The latent vectors produced by these two types of generators then undergo latent space oversampling and are used in the training of a discriminator of the GAN-COS module. The latent vectors may then be combined and used to form the augmented training dataset.

IPC Classes  ?

• G06N 3/094 - Adversarial learning
• G06N 20/00 - Machine learning
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

Abstract

Virtual screening methods are disclosed for predicting interacting compounds, from a chemical library, for proteins. The methods using an Extremely Randomized Trees (Extra Trees) machine learning model in which parent node(s) represent a decision in relation to a target-compound complex, based on a plurality of features corresponding to a protein target of the complex and a plurality of features corresponding to a compound of the complex, and leaf nodes classify the target-compound complex as either interacting or non- interacting. The Extra Trees model outputs a probability that target-compound complex is interacting, based on aggregated classifications from each decision tree. Applying the Extra Trees model to a further protein target and compounds produces a probability that each compound will form an interacting complex with the further protein target. The compounds are then ranked based on the respective probabilities, and highest probability compounds are then explored using a docking model.

IPC Classes  ?

• G16C 20/64 - Screening of libraries
• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G06F 17/10 - Complex mathematical operations

Abstract

The present disclosure relates to antigen-binding molecules that bind to human and feline Human Trophoblast Cell Surface Antigen 2 (TROP2). The specific embodiments relate to antibody-drug conjugates (ADC) comprising saporin, mertansine and MMAE and chimeric antigen receptors (CAR) comprising said antigen-binding molecules for use in treatment of cancer.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• G01N 33/577 - ImmunoassayBiospecific binding assayMaterials therefor involving monoclonal antibodies
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates generally to the field of molecular biology. In particular, the invention is directed to a vector for generating a circular RNA. Methods for generating circular RNA from a precursor RNA transcribed from the vector are also provided herein.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

A method and apparatus for extracting commands between a controller and an operator, the method comprising: receiving a command and a response to the command; extracting an instruction from the command using a trained neural network model that processes text in a bidirectional manner; comparing the extracted instruction from the command and the response to the command to find text that is similar; and extracting text in the response to the command found to be most similar to the text in the extracted instruction of the command, wherein a fuzzy matching algorithm is used for comparing the extracted instruction of the command and the response to the command to find text that is similar, wherein the fuzzy matching algorithm compares a span of the extracted instruction of the command with a span of the response to the command and calculates a similarity score for the two compared spans.

IPC Classes  ?

• G06Q 50/40 - Business processes related to the transportation industry
• G10L 15/16 - Speech classification or search using artificial neural networks
• G08G 5/20 - Arrangements for acquiring, generating, sharing or displaying traffic information
• G06N 3/0442 - Recurrent networks, e.g. Hopfield networks characterised by memory or gating, e.g. long short-term memory [LSTM] or gated recurrent units [GRU]
• G06N 20/00 - Machine learning

Abstract

The present disclosure relates to a method of preparing a copper-based catalyst. The method comprises mixing a colloidal solution containing a hydroxycarbonate precursor comprising copper (Cu), zinc (Zn) and zirconium (Zr) cations, with a tetraethyl orthosilicate (TEOS) and ethanol mixed solution to obtain a solution; adjusting pH of the solution; isolating a solid phase from the solution; drying the solid phase; and calcining the solid phase to obtain a silicon dioxide (SiO2)encapsulated copper-based catalyst consisting of Cu-Zn-Zr ternary metal oxide nanoparticles encapsulated in silicon dioxide (SiO2), represented by Cu-Zn-ZrOx@SiO2.

IPC Classes  ?

• B01J 35/53 - Spheres with a core-shell structure
• B01J 23/80 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with zinc, cadmium or mercury
• B01J 21/08 - Silica
• B01J 37/03 - PrecipitationCo-precipitation
• C07C 29/154 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of oxides of carbon exclusively with hydrogen or hydrogen-containing gases characterised by the catalyst used containing copper, silver, gold, or compounds thereof

Abstract

A method of orthogonal time frequency space (OTFS)-based radar sensing is provided. The method includes: performing an OTFS demodulation based on a time domain signal or a Delayed-Time (DT) domain signal received and reflected from one or more objects from a time domain signal or a DT domain signal transmitted, the time domain signal or the DT domain signal transmitted being generated from an OTFS modulation based on a first Delay-Doppler (DD) domain signal; determining a two-dimensional (2D) range-Doppler map based on a first Time-Frequency (TF) domain signal associated with the first DD domain signal and a second TF domain signal associated with the time domain signal or the DT domain signal received; and performing radar sensing based on the 2D range-Doppler map. There is also provided a corresponding system for OTFS-based radar sensing.

IPC Classes  ?

• G01S 13/02 - Systems using reflection of radio waves, e.g. primary radar systemsAnalogous systems
• H04L 27/26 - Systems using multi-frequency codes
• G01S 7/02 - Details of systems according to groups , , of systems according to group

Abstract

This document describes a slot waveguide modulator that utilizes both silicon photonics and electro-optic materials to achieve high bandwidth, high efficiency and low optical loss. The slot waveguide modulator has an electro-optic layer that is sandwiched between two mode stopper layers, where the mode stopper layers are formed in waveguide layers having a refractive index that is higher than the refractive index of the electro-optic layer.

IPC Classes  ?

• G02F 1/035 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect in an optical waveguide structure
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference

Abstract

A motor includes a housing, a stator, and a rotor assembly. The housing defines a primary axis axially extending through a first end and a second end of the housing. The stator is fixedly disposed at the first end of the housing and axially spaced apart from the second end of the housing. The rotor assembly includes a support frame and a rotor. The support frame is rotatable about the primary axis relative to the housing. The support frame includes a plurality of rods. The plurality of rods are constrained from an axial displacement relative to the housing. The rotor includes a plurality of rotor magnets. The rotor is disposed on the support frame. The rotor and the support frame are rotatable as a body about the primary axis, with the rotor axially displaceable relative to the support frame.

IPC Classes  ?

• H02K 7/12 - Structural association with clutches, brakes, gears, pulleys or mechanical starters with auxiliary limited movement of stators, rotors or core parts, e.g. rotors axially movable for the purpose of clutching or braking
• H02K 21/14 - Synchronous motors having permanent magnetsSynchronous generators having permanent magnets with stationary armatures and rotating magnets with magnets rotating within the armatures
• H02K 5/04 - Casings or enclosures characterised by the shape, form or construction thereof
• H02K 1/06 - Details of the magnetic circuit characterised by the shape, form or construction

Abstract

The present invention relates generally to the field of stem cell differentiation. In particular, the invention relates to a serum-free method for differentiating stem cells into multipotent mesenchymal stromal cells (MSCs). The invention also relates to serum-free media for cell culture. In an aspect of the present invention, there is provided a serum-free composition for differentiating pluripotent stem cells into multipotent MSCs, the composition comprising Dulbecco's Modified Eagle Medium (DMEM), KnockOut™ Serum Replacement (KOSR) and GlutaMAX.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

In some embodiments, a method for forming a three-dimensional metasurface is provided. The method includes: forming a three-dimensional metasurface based on a two-dimensional metasurface, wherein the two-dimensional metasurface comprises a plurality of nanostructures including first to N-th nanostructures, wherein N is an integer greater than or equal to 2, each of the plurality of nanostructures comprising a mask layer and a dielectric layer disposed under the mask layer, wherein the forming a three-dimensional metasurface based on a two-dimensional metasurface comprises: removing an i-th mask layer of the i-th nanostructure of the plurality of nanostructures; and etching an i-th dielectric layer of the i-th nanostructure of the plurality of nanostructure.

IPC Classes  ?

• H01Q 15/00 - Devices for reflection, refraction, diffraction or polarisation of waves radiated from an antenna, e.g. quasi-optical devices
• G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements
• H01Q 17/00 - Devices for absorbing waves radiated from an antenna Combinations of such devices with active antenna elements or systems
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• G01Q 60/24 - AFM [Atomic Force Microscopy] or apparatus therefor, e.g. AFM probes

Abstract

Various embodiments may relate to a radome. The radome may include a plurality of meta- material unit cells. The plurality of meta-material unit cells may be arranged such that one or more layers of meta-material unit cells of the plurality of meta-material unit cells are arranged in a concentric arrangement around a central meta-material unit cell of the plurality of meta- material unit cells to form a honeycomb arrangement. The depths of the plurality of meta- material unit cells of at least a portion of the one or more layers may vary in a substantially parabolic manner with the layer of the one or more layers from the central meta-material unit cell.

IPC Classes  ?

• H01Q 1/42 - Housings not intimately mechanically associated with radiating elements, e.g. radome
• H01Q 15/00 - Devices for reflection, refraction, diffraction or polarisation of waves radiated from an antenna, e.g. quasi-optical devices

Abstract

There is provided an antenna array and a method of calibrating an antenna array comprising a plurality of subarray modules, each subarray module comprising a plurality of antenna elements, said method comprising, performing an intra-module calibration by measuring and correcting mismatches in amplitude and phase of antenna elements within each subarray module of the plurality of subarray modules; and performing an inter-module calibration by measuring and correcting misalignments between the plurality of subarray modules.

IPC Classes  ?

• H04B 17/12 - MonitoringTesting of transmitters for calibration of transmit antennas, e.g. of amplitude or phase
• H04B 17/21 - MonitoringTesting of receivers for calibrationMonitoringTesting of receivers for correcting measurements
• H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart

Abstract

There is provided a phased array antenna, a modular phased array antenna system, and a method of making a phased array antenna, the phased array antenna comprising, an Rx antenna array comprising one or more Rx subarrays of Rx antenna elements configured to receive via a first frequency range; and a Tx antenna array comprising one or more Tx subarrays of Tx antenna elements configured to transmit via a second frequency range; wherein the Rx antenna array and Tx antenna array are disposed on a same aperture; wherein the Rx antenna element is separate from the Tx antenna element; and wherein any two immediately adjacent Rx antenna elements and any two immediately adjacent Tx antenna elements are separated by a distance D along a first direction and a second direction perpendicular to the first direction.

IPC Classes  ?

• H01Q 5/40 - Imbricated or interleaved structuresCombined or electromagnetically coupled arrangements, e.g. comprising two or more non-connected fed radiating elements
• H01Q 5/42 - Imbricated or interleaved structuresCombined or electromagnetically coupled arrangements, e.g. comprising two or more non-connected fed radiating elements using two or more imbricated arrays
• H01Q 21/28 - Combinations of substantially independent non-interacting antenna units or systems

Abstract

The present disclosure relates to a topologically complex polymer comprising at least one functionalized macromolecule coupled to a plurality of antimicrobial peptides via a plurality of furcated linkers, wherein each antimicrobial peptide is bonded to each furcated terminal end of the furcated linker. The present disclosure also relates to a method of preparing the topologically complex polymer, a method of preparing a packaging material comprising the topologically complex polymer and a packaging material comprising the topologically complex polymer as defined herein.

IPC Classes  ?

• C08G 8/36 - Chemically modified polycondensates by etherifying
• C08L 65/00 - Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chainCompositions of derivatives of such polymers
• C07K 2/00 - Peptides of undefined number of amino acidsDerivatives thereof
• A01N 39/00 - Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or , e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
• A01N 37/18 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N, e.g. carboxylic acid amides or imidesThio-analogues thereof
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
• A23B 99/00 - Subject matter not provided for in other groups of this subclass
• A61K 47/56 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
• A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds

Abstract

The present disclosure concerns compounds for use as pan-TEAD inhibitors and methods of treating NF2, EGFR and/or KRAS/G12C mutated cancer and/or tumor using the compounds. The compounds may be used in combination with a EGFR inhibitor and/or a KRAS/G12C inhibitor.

IPC Classes  ?

• C07D 231/40 - Acylated on said nitrogen atom
• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 277/46 - Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
• A61K 31/415 - 1,2-Diazoles
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 35/00 - Antineoplastic agents

Abstract

A model is trained to predict collision-energy specific tandem mass spectra (MS/MS) for molecules. Directed acyclic graphs (DAG) are generated, that structurally relates predicted fragments for each molecule. A fragmentation model is then trained based on the DAGs and respective molecular inputs, to generate most probable fragments based on molecular inputs. The input data is then binned, with each bin corresponding to a non-overlapping collision energy range. The trained fragmentation model is frozen and intensity models (one for each bin) are trained to predict MS/MS spectra for molecules based on fragments generated by the fragmentation model.

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
• G16C 20/70 - Machine learning, data mining or chemometrics
• G16C 20/20 - Identification of molecular entities, parts thereof or of chemical compositions
• G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment

Abstract

There is provided a thermoelectric photodetector device including: a substrate; an array of resonant nanostructures formed at a portion of the substrate; a first thin film of thermoelectric material of a first conductivity type including a thermocouple portion disposed over the array of resonant nanostructures, the first thin film extends from the thermocouple portion to connect to an electrode; and a second thin film of thermoelectric material of a second conductivity type including a thermocouple portion disposed over the array of resonant nanostructures, the second thin film extends from the thermocouple portion to connect to another electrode. In particular, the thermocouple portion of the first thin film and the thermocouple portion of the second thin film overlap with each other to form a thin film stack coating the array of resonant nanostructures. In this regard, the thin film stack constitutes a thermocouple region including a thermoelectric junction. There is also provided a method of fabricating the thermoelectric photodetector device.

IPC Classes  ?

• H10F 30/22 - Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation the devices having only one potential barrier, e.g. photodiodes
• H10F 71/00 - Manufacture or treatment of devices covered by this subclass
• H10F 77/14 - Shape of semiconductor bodiesShapes, relative sizes or dispositions of semiconductor regions within semiconductor bodies
• G01K 7/02 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using thermoelectric elements, e.g. thermocouples

Abstract

This disclosure concerns insertion/deletion (indel) gene signatures and non-genetic factors that may be used to predict vaccine response, and methods of use thereof.

IPC Classes  ?

• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• G06F 17/18 - Complex mathematical operations for evaluating statistical data

Abstract

Described herein is a composition comprising an alginate salt and a polyimidazolium salt, the polyimdazolium salt forms crosslinks in the alginate salt. The composition may be used a composite material, a gel, an aqueous solution, and a sheet. Methods of preparing the composition are described as well.

IPC Classes  ?

• A61L 15/26 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bondsDerivatives thereof
• A61L 15/28 - Polysaccharides or their derivatives
• A61L 15/44 - Medicaments
• A61L 27/26 - Mixtures of macromolecular materials
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08L 79/06 - PolyhydrazidesPolytriazolesPolyamino-triazolesPolyoxadiazoles
• C08L 5/04 - Alginic acidDerivatives thereof
• A01N 33/12 - Quaternary ammonium compounds

Abstract

A device for color conversion is provided. The device comprises a Distributed Bragg Reflector (DBR) structure on a substrate and a metasurface comprising a plurality of nanostructures is disposed on the DBR. Each nanostructure includes a first dielectric layer with a first refractive index on a second dielectric layer with a second refractive index, the first refractive index being different from the second refractive index. An active medium comprising quantum dots is disposed in between the plurality of nanostructures. The geometric parameters of the plurality of nanostructures are controlled such that the cavity modes of different natures can be tailored to match the absorption spectra of the active medium. This enhances absorption of incident light and color-conversion efficiency.

IPC Classes  ?

• H10H 29/851 - Wavelength conversion means
• G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour

Abstract

The invention relates to antigen-binding molecules that specifically bind to IgM μ-chain antigen. In one embodiment, the antigen-binding molecule is an antibody that specifically binds to canine IgM μ-chain antigen. Chimeric molecules of the antibody conjugated to another heterologous moiety are also provided. In one embodiment, the heterologous moiety is monomethyl auristatin E (MMAE). A method of inhibiting cancer using the antibody or the chimeric molecule thereof is also provided. In another embodiment, the antibody-MMAE conjugate suppresses tumour development in a murine model of B cell lymphoma.

IPC Classes  ?

• C07K 16/42 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against immunoglobulins (anti-idiotypic antibodies)
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents

Abstract

This technology relates to anti-bacterial peptides and method of treating infections using the peptides.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

An optical, programmable Ising machine uses a master laser for injection locking one or both of the optical frequency and polarization state of slave beams from a plurality of slave lasers—the slave lasers represent Ising bits. The slave beams are split into two or more coupling beams. Some of the coupling beams are rotated (e.g., by) 90°, so that the coupling beams can represent both positive and negative coupling terms between the Ising bits. The coupling beams are then combined and directed back into the optical cavities of the slave lasers, to provided optical feedback, to evolve the state of the Ising machine.

IPC Classes  ?

• H01S 5/065 - Mode lockingMode suppressionMode selection
• G02B 27/10 - Beam splitting or combining systems
• G02B 27/28 - Optical systems or apparatus not provided for by any of the groups , for polarising
• G06E 1/00 - Devices for processing exclusively digital data

Abstract

Disclosed is a server apparatus for image processing, the server apparatus comprising an input module, the input module configured to obtain input image data, the input image data comprising a plurality of differently exposed images; an image processing module configured to process the plurality of differently exposed images to generate a composite image; wherein the image processing module comprises a neural augmented multi-scale exposure fusion function, the neural augmented multi-scale exposure fusion function comprises: a plurality of levels; one or more weight maps of the plurality of differently exposed images, each weight in the one or more weight maps associated with an image of the plurality of differently exposed images; a plurality of first pyramids corresponding to the plurality of levels, the plurality of first pyramids generated based on the one or more weight maps; and a plurality of hybrid pyramids, each of the plurality of hybrid pyramids constructed based on at least one edge- preserving smoothing function using the plurality of first pyramids as input.

IPC Classes  ?

• G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction

Abstract

Disclosed is a method of predicting optimal exposure times for one or more non-overlapping blocks of an image, comprising: training an artificial intelligence module on a dataset comprising temporary images of a first scene and corresponding sets of ground-truth optimal exposure times for all pixels of each temporary image; obtaining a temporary image of a second scene and determining an initial exposure time of the temporary image of the second scene; inputting the temporary image of the second scene and its initial exposure time into the trained artificial intelligence module; and, generating, by the artificial intelligence module, a set of predicted optimal exposure times for the non-overlapping blocks of the temporary image of the second scene.

IPC Classes  ?

• G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• G06T 5/94 - Dynamic range modification of images or parts thereof based on local image properties, e.g. for local contrast enhancement

Abstract

A device includes a finned cooling structure and a shroud. The shroud defines a primary inlet, an outlet, and a channel extending along a longitudinal axis from the primary inlet to the outlet. The finned cooling structure is disposed in the channel between the primary inlet and the outlet. The shroud defines a plurality of secondary openings proximal to the finned cooling structure.

IPC Classes  ?

• F28F 9/22 - Arrangements for directing heat-exchange media into successive compartments, e.g. arrangements of guide plates
• F28D 9/00 - Heat-exchange apparatus having stationary plate-like or laminated conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall
• H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating

Abstract

Disclosed herein is a formulation for producing a bacterial cellulose-based leather comprising: (a) bacterial cellulose; (b)a gelling agent; (c) a plasticizer; (d)a crosslinker; and (e) a filler. Also disclosed herein is a method of producing a bacterial cellulose-based leather comprising the following steps: (i) providing the formulation; and (ii) pouring the formulation into a mould and casting the formulation at 70 to 90°C for 18 to 24 hours to obtain the bacterial cellulose-based leather.

IPC Classes  ?

• C08L 1/02 - CelluloseModified cellulose
• D04H 1/425 - Cellulose series
• D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
• D06N 3/02 - Artificial leather, oilcloth, or like material obtained by covering fibrous webs with macromolecular material, e.g. resins, rubber or derivatives thereof with cellulose derivatives

Abstract

The invention relates to methods for producing an antibody which is specific for a mutant p53 polypeptide over wildtype p53 polypeptide, comprising using as an immunogen a peptide or polypeptide comprising: (i) an antigen sequence, comprising an amino acid sequence of the mutant p53 polypeptide including the mutation and at least one amino acid immediately adjacent to the mutation, and (ii) a scaffold sequence for providing the antigen sequence in a solvent-accessible configuration. Also provided are antibodies produced by such methods, and uses thereof.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 49/00 - Preparations for testing in vivo
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to a fully digital pulse width modulation module for generating sub-nanosecond pulses in a linear manner and within a wide dynamic range. The module comprises a PWM signal generator module which is configured to generate an output pulse signal having a predetermined width in response to receiving an input pulse signal through an edge detector and a coarse delay module. A digital calibrator is coupled to the PWM signal generator module and configured to adjust a frequency of the signal generated by the coarse delay module based on a target frequency, a reference clock frequency and a predetermined threshold of clock cycles.

IPC Classes  ?

• H03K 7/08 - Duration or width modulation
• H03K 5/131 - Digitally controlled
• G06F 1/02 - Digital function generators

Abstract

π. π.

IPC Classes  ?

• G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02F 1/225 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference in an optical waveguide structure

Abstract

624262830333752701767880909597103116124131133137138163164168170172179180182183184186188189191193194195196197204208219221223224226228233235239246247248250253255262263269277280283286286A (SEQ ID NO: 1), wherein X is a natural amino acid, and wherein the variant comprises one or more mutations at a site selected from the group consisting of an ion-egress site, a S-Adenosyl-L-Methionine (SAM) binding site, an ion-binding site (IBS), and a conserved site. Also disclosed are polynucleotides encoding the variants, vectors comprising the polynucleotides encoding the variants, and host cells comprising the vectors thereof. Also disclosed are Methods for producing the variants, methods of catalyzing the fluorination of a compound, uses of the fluorinase variants, and methods of treatment using the fluorinase variants thereof.

IPC Classes  ?

• C12N 9/10 - Transferases (2.)
• C12N 15/54 - Transferases (2)

Abstract

The present invention relates to a method of increasing protein expression in a cell-free protein synthesis (CFPS) system, comprising supplementing the CFPS system with one or more compounds which increase expression of the protein, wherein the one or more compounds is selected from the group consisting of bosutinib, cerdulatinib, dasatinib, neratinib, afatinib, nafarelin and polymyxin B. Proteins obtained by the method and a CFPS system supplemented with a combination of cerdulatinib and nafarelin are also provided.

IPC Classes  ?

• C12P 21/00 - Preparation of peptides or proteins

Abstract

Disclosed in the present invention is a stretchable rigid-flexible interconnection structure having gradient rigidity, comprising: a support body; a stretchable substrate provided on a side of the support body; a stretchable circuit layer and a non-stretchable circuit layer both provided on the side of the stretchable substrate facing away from the support body, the non-stretchable circuit layer and the support body being arranged opposite to each other, the non-stretchable circuit layer and the stretchable circuit layer being electrically connected to each other and having an overlapping area at a junction, and the projection of the support body on the stretchable substrate covering the projection of the non-stretchable circuit layer on the stretchable substrate; and a sealing layer provided on the side of the stretchable circuit layer facing away from the stretchable substrate and covering the stretchable circuit layer, the stretchable circuit layer having a stretching direction and a normal direction, and the support body having gradient rigidity in the stretching direction or in the normal direction. On the basis of the support body having gradient rigidity, the stretchable rigid-flexible interconnection structure of the present invention can reduce the risk of an interconnection interface being prone to detachment and breakage, and exhibits high stability and reliability.

IPC Classes  ?

• H05K 1/03 - Use of materials for the substrate
• H05K 1/14 - Structural association of two or more printed circuits
• H05K 1/02 - Printed circuits Details

Abstract

Disclosed in the present invention are a stretchable rigid-flex interconnection member and a manufacturing method therefor. The method comprises: providing a stretchable substrate, and printing silver paste and a liquid metal composite material respectively on a first side of the stretchable substrate to form a non-stretchable circuit layer and a stretchable circuit layer, respectively, to obtain a first rigid-flex composite structure, wherein an overlapping area exists at a junction of the non-stretchable circuit layer and the stretchable circuit layer; providing a sealant, and using the sealant to encapsulate the first rigid-flex composite structure to form a sealing layer, such that the stretchable circuit layer is covered by the sealing layer to obtain a second rigid-flex composite structure; and providing a support layer, and attaching the support layer to a second side of the second rigid-flex composite structure to obtain a target rigid-flex interconnection member. In the present invention, the rigid-flex interconnection member for electronic interconnection between a rigid circuit system and a flexible circuit system can be truly formed, and the entire rigid-flex interconnection member has excellent stretchable performances, and can meet the requirements of rigid-flex interconnection electronic products such as wearable electronic devices at the current stage.

IPC Classes  ?

• H05K 1/09 - Use of materials for the metallic pattern

Abstract

In some embodiments, a tunable lens is provided. The tunable lens includes a substrate; at least one layer of ferroelectric material disposed over the substrate; and a first electrode disposed on the at least one layer of ferroelectric material; wherein a refractive index of the at least one layer of ferroelectric material is tunable by applying an electric field through the first electrode.

IPC Classes  ?

• G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements
• G02F 1/05 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect with ferro-electric properties
• G02B 3/08 - Simple or compound lenses with non-spherical faces with discontinuous faces, e.g. Fresnel lens
• H01Q 15/02 - Refracting or diffracting devices, e.g. lens, prism

Abstract

There is provided a system and method of performing automated screening of thermoelectric materials, the system comprising, a temperature control stage for introducing a temperature gradient, said temperature control stage comprising a thermally conductive sheet dimensioned to support a wafer having a diameter of at least 4 inches and a plurality of samples disposed on a surface thereof; a thermal camera for measuring a temperature profile along the wafer and a temperature gradient across each sample disposed on the wafer; an electrical probe for performing electrical measurements on the plurality of samples; and a processing unit for determining one or more thermoelectric properties of the plurality of samples based on the electrical measurements; wherein the electrical probe is configured to move, in response to instructions from a vision algorithm, to target locations associated with the plurality of samples.

IPC Classes  ?

• G01R 31/26 - Testing of individual semiconductor devices
• G01R 27/00 - Arrangements for measuring resistance, reactance, impedance, or electric characteristics derived therefrom
• G01N 25/00 - Investigating or analysing materials by the use of thermal means

Abstract

There is provided material for preventing or reducing scar formation during wound healing, the material comprising: (i) a base poly(lactic-co-glycolic acid) (PLGA); and (ii) a bioactive poly(lactic-co-glycolic acid) (PLGA) copolymer, wherein at least part of the material is in the form of a plurality of protrusions extending from a surface. Also provided are a medical device comprising said material, medical uses of said material, and a method of preparing said material.

IPC Classes  ?

• A61K 9/70 - Web, sheet or filament bases
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• A61K 31/28 - Compounds containing heavy metals
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
• B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
• A61P 17/00 - Drugs for dermatological disorders
• C08L 45/02 - Compositions of homopolymers or copolymers of compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic or in a heterocyclic ring systemCompositions of derivatives of such polymers of coumarone-indene polymers
• C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• B33Y 80/00 - Products made by additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing

Abstract

Targeting Metabolic Pathways with MNK Inhibitors The invention belongs to the field of medicine and concerns the treatment of diseases related to aberrant upregulated de novo lipid biosynthesis using a MAPK interacting kinase (MNK) inhibitor, especially for the prophylaxis or treatment of breast cancers, prostate cancers, obesity, atherosclerosis, diabetes mellitus, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, chronic kidney disease, and neurological disorders. An aspect of the invention relates to the use of an MNK inhibitor designated (4-(3-((2- (dimethylamino)pyridin-4-yl)ethynyl)pyrazolo[1,5-a]pyrimidin-5-yl)phenyl)(morpholino) methanone, for the prophylaxis or treatment of triple-negative breast cancer and brain metastases therefrom.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis

Abstract

There is provided a method of preparing a polymeric matrix comprising a step of polymerizing a mixture comprising a salt monomer, a crosslinker and an initiator in the presence of water and an organic solvent, wherein the salt monomer is a metal salt of an organic acid comprising at least one C=C bond, and wherein the crosslinker comprises at least 9 ethoxy groups and at least two C=C bonds. There is also provided a polymeric matrix obtained or obtainable from the method as described herein and a device comprising the polymeric matrix.

IPC Classes  ?

• C08F 2/06 - Organic solvent
• C08F 2/10 - Aqueous solvent
• C08F 220/06 - Acrylic acidMethacrylic acidMetal salts or ammonium salts thereof
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08J 5/00 - Manufacture of articles or shaped materials containing macromolecular substances

Abstract

A polymer selected from the group consisting of Formula 1, Formula 2, and Formula 3 is described. An example of the polymer is Formula 4. The polymer contains a polyolefin backbone and is grafted with a polar functional group that is attached to an epoxy containing component. The polymer may be used in recycling plastic and as a compatibilizer.

IPC Classes  ?

• C08F 8/08 - Epoxidation
• C08F 8/14 - Esterification
• C08F 24/00 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygen
• C08L 37/00 - Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a heterocyclic ring containing oxygenCompositions of derivatives of such polymers
• C08F 20/32 - Esters containing oxygen in addition to the carboxy oxygen containing epoxy radicals
• C08L 33/16 - Homopolymers or copolymers of esters containing halogen atoms

Abstract

Systems and methods for delineating tumour boundaries using a three-dimensional (3D) image stack, such as photoacoustic image slices, comprising a plurality of images. Multiple maximum intensity projections (MIPs) are derived from the stack, and level set segmentation is performed on those MIPs, to derive a boundary that bounds a region of interest (i.e., a tumour boundary). Structural and functional information is then derived for the region of interest, to analyse the tumour tissue.

IPC Classes  ?

• G06T 7/10 - SegmentationEdge detection
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics

Abstract

The invention relates to generally to the field of molecular biology. In particular, the invention is directed to a vector for generating a circular RNA. Methods for generating circular RNA from a precursor RNA transcribed from the vector are also provided herein.

IPC Classes  ?

• C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle

Abstract

A vector comprising an intron having endogenous 5' and 3' splice sites, and one or more exogenous 3' splice sites downstream of and/or within the intron. Also provided are polynucleotides encoding the construct, host cells comprising the construct, kits thereof, a method of producing/increasing production of a protein of interest, and a method of preventing abnormal/incorrect splicing.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

Various embodiments may relate to a stacked arrangement. The stacked arrangement may include a substrate. The stacked arrangement may also include a buffer layer over the substrate, the buffer layer including zirconium nitride (ZrN). The stacked arrangement may further include a metal layer on the buffer layer. A crystal lattice orientation of the metal layer may be substantially in alignment with a crystal lattice orientation of the buffer layer.

IPC Classes  ?

• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• C23C 14/16 - Metallic material, boron or silicon on metallic substrates or on substrates of boron or silicon
• H10N 30/05 - Manufacture of multilayered piezoelectric or electrostrictive devices, or parts thereof, e.g. by stacking piezoelectric bodies and electrodes

Abstract

According to embodiments of the present invention, a method for performing contactless detection of ultrasound waves from a target to generate an ultrasound image based on the target is provided. The method includes emitting an optical coherence tomography (OCT) beam sequentially at a plurality of stationary beam locations across a sensing region of the ultrasound waves; at each stationary beam location, measuring OCT signals periodically for an acquisition cycle and extracting intermediate phase data from the measured OCT signals; for the plurality of stationary beam locations, concatenating the intermediate phase data to generate displacement data and deriving ultrasound data from time derivatives of the displacement data; and applying a reconstruction algorithm on the ultrasound data to generate the ultrasound image. According to further embodiments, a system for performing the same and a processing unit operable with an OCT apparatus to carry out the method are also provided.

IPC Classes  ?

• G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
• A61B 8/13 - Tomography

Abstract

Various embodiments may relate to a terahertz (THz) imager. The terahertz imager may include a reflector layer. The terahertz imager may also include an absorber on the reflector layer. The absorber may be or may include a dielectric spacer. The terahertz imager may further include a microelectromechanical system (MEMS)-based metasurface on or over the absorber. The terahertz imager may additionally include a sensing layer.

IPC Classes  ?

• G01J 3/28 - Investigating the spectrum
• G01J 5/10 - Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors
• H10F 39/12 - Image sensors

Abstract

Provided herein are methods of treating dystrophinopathies and associated conditions using LING complex inhibitors. In one embodiment, the dystrophinopathy is selected from Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) and DMD-associated dilated cardiomyopathy (DCM). In another embodiment, the associated condition is a myopathy and/or muscular dystrophy. In a further embodiment, the LING complex inhibitor is a dominant negative SUN1 (DNSUN1) polypeptide.

IPC Classes  ?

• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

A flame retardant polyamide composite that includes a polyamide and a synergist, where the synergist includes a polymer having a backbone and a side unit of 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide bonded thereto. Furthermore, the backbone of the polymer includes at least one heterocyclic moiety. Additionally, the flame retardant polyamide composite includes a flame retardant agent, where the synergist and the flame retardant agent are present in an amount ranging from more than 0 to 10 wt %. Furthermore, a method of forming the flame retardant polyamide composite includes cryogenic milling a synergist, mixing the synergist with a flame retardant agent to obtain a mixture, and compounding the mixture with a polyamide to obtain the flame retardant polyamide composite.

IPC Classes  ?

• C08L 77/02 - Polyamides derived from omega-amino carboxylic acids or from lactams thereof
• C08J 3/20 - Compounding polymers with additives, e.g. colouring
• C08K 3/38 - Boron-containing compounds
• C08K 5/053 - Polyhydroxylic alcohols
• C08K 5/3492 - Triazines
• C08K 5/52 - Phosphorus bound to oxygen bound to oxygen only
• C08K 5/5313 - Phosphinic compounds, e.g. R2=P(:O)OR'

Abstract

Ramazzottius varieornatus Ramazzottius varieornatus X family DNA polymerase (RvPoIX) with enhanced salt-tolerant template-independent DNA polymerase activity, comprising at least one amino acid substitution corresponding to positions 281, 513, and/or 522 as set forth in SEQ ID NO: 1. The amino acid substitution at the position corresponding to position 281 may be a substitution to A, F, I, L, V, or Y. The amino acid substitution at the position corresponding to position 513 may be a substitution to A or C. The amino acid substitution at the position corresponding to position 522 may be a substitution to I, M, or V. Also disclosed are methods of nucleic acid synthesis using said DNA polymerase.

IPC Classes  ?

• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/54 - Transferases (2)
• C12Q 1/686 - Polymerase chain reaction [PCR]

Abstract

A package (100) for cooling a radio-frequency (RF) circuit (1 10) is described. In an embodiment, the package (100) comprises a hollow waveguide (102) having a first end (104), a second end (106), and a sidewall (108) connecting the first end (104) and the second end (106) to form an enclosure for the RF circuit (1 10), the first end (104) being opposite to the second end (106). The hollow-waveguide (102) has through-holes (112) formed on one or more portions of the sidewall (108), and the through-holes (112) are adapted to allow a liquid coolant to flow through the hollow waveguide (102) for cooling the RF circuit (1 10). In use, the hollow waveguide (102) is completely filled with the liquid coolant, and is adapted to propagate a RF signal from the first end (104) to the second end (106) of the hollow waveguide (102). Embodiments in relation to a system (1000) for cooling a radio-frequency (RF) circuit (1 10) is also described.

IPC Classes  ?

• H01P 3/12 - Hollow waveguides
• H01L 23/473 - Arrangements for cooling, heating, ventilating or temperature compensation involving the transfer of heat by flowing fluids by flowing liquids
• H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating
• H01P 1/30 - Auxiliary devices for compensation of, or protection against, temperature or moisture effects

Abstract

The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
• A61P 35/00 - Antineoplastic agents
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C07K 16/44 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

There is provided a nanoparticle for delivery of a therapeutic agent, the nanoparticle comprising a surface structure which comprises a cationic lipid and an ionizable lipid in a ratio that falls in the range of 1 -5 : 5-1.

IPC Classes  ?

• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• A61K 9/51 - Nanocapsules
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

The disclosure relates to a method of treating cancer or reducing the risk of recurrence of cancer in a subject, the method comprising administering to the subject an inhibitor of Monocarboxylate Transporter 1 (MCT1). In one embodiment, the cancer is associated with overexpression of CD147 in one or more tumor initiating cells. In one embodiment, the cancer comprises lung cancer such as non-small cell lung cancer (NSCLC). In one embodiment, the cancer is a ketone-dependent cancer. In one embodiment, the subject is one who has been provided a ketogenic diet.

IPC Classes  ?

• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 35/00 - Antineoplastic agents

Abstract

An epidermal biosensor comprising a diffusion layer operable to dissolve a solid-phase epidermal analyte, an enzymatic bioreceptor operable to oxidise the dissolved epidermal analyte from the diffusion layer, a transducer having an interface with the diffusion layer, a processor configured to process electrochemical data from the transducer, and a substrate to which the enzymatic bioreceptor and the transducer are attached. The solid-phase epidermal analyte may include water-insoluble cholesterol and water-soluble lactate. The diffusion-solvation layer may comprise agarose hydrogel and additives including glycerol and/or gelatin to improve mechanical robustness and reduce water evaporation rate of the hydrogel, and ethanol and/or Triton X-100 to facilitate solvation and transportation of hydrophobic analytes.

IPC Classes  ?

• A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
• A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase

Abstract

The invention provides a process for inserting amide linkages into a polyolefin, the process comprising the steps of: (i) providing a polyoxime derived from the oxidation of a polyolefin into a polyketone and subsequently converting the polyketone into the polyoxime; and (ii) subjecting the polyoxime to a Beckmann rearrangement reaction in the presence of a dehydrating reagent to obtain a polyamide. The invention also provides a process to provide a reformed polyamide, the process comprising the steps of: (iii) subjecting a polyamide comprising a plurality of amide groups obtained from the process disclosed hereinbefore to hydrolysis conditions to cleave at least a portion of the amide groups to provide an intermediate mixture comprising a plurality of different compounds comprising carboxylic acid groups, amine groups or both; and (iv) generating a reformed polyamide from the intermediate mixture in the presence of a suitable catalyst.

IPC Classes  ?

• C08G 69/50 - Polymers modified by chemical after-treatment with aldehydes
• C08F 8/30 - Introducing nitrogen atoms or nitrogen-containing groups
• C08F 8/06 - Oxidation
• C08F 8/50 - Partial depolymerisation
• C08J 99/00 - Subject matter not provided for in other groups of this subclass
• C08J 11/14 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with steam or water
• C08F 10/00 - Homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond

Abstract

OTCOTC OTCOTC gene.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
• A61P 3/00 - Drugs for disorders of the metabolism

Abstract

There is provided a device for skin bioprinting and a method of making a device for skin bioprinting, the device comprising: a dispenser module configured to actuate and dispense a bioink from a first chamber, and to actuate and dispense a crosslinker from a second chamber: a storage module coupled to the dispenser module, the storage module comprising the first chamber for storing the bioink and the second chamber for storing the crosslinker; a mixing module coupled to the storage module for mixing the bioink and the crosslinker dispensed from the first and second chambers respectively; and a rotatable applicator coupled to the mixing module for rotatably applying a mixture of the bioink and crosslinker from the mixing module onto a surface of a patient in need of skin regeneration.

IPC Classes  ?

• A61F 2/10 - Hair or skin implants
• A61M 35/00 - Devices for applying media, e.g. remedies, on the human body

Abstract

A method and system for navigating a robot 100 in a designated environment are provided herein. In an embodiment, the method comprises: selectively identifying reference features from a scale plan of the designated environment; generating a topometric map 178 of the designated environment, the topometric map 178 being associated with the identified reference features; generating an initial navigation path 176 of a local region 174 from the topometric map 178; as the robot 100 navigates along the initial navigation path 176 of the local region 174, detecting onsite reference features of the local region 174 that correspond to the identified reference features of the scale plan; and updating the topometric map 178 based on the correspondence to generate a regional path plan 188 to guide the robot's direction in the local region 174.

IPC Classes  ?

• G05D 1/246 - Arrangements for determining position or orientation using environment maps, e.g. simultaneous localisation and mapping [SLAM]
• G05D 1/646 - Following a predefined trajectory, e.g. a line marked on the floor or a flight path
• G05D 107/60 - Open buildings, e.g. offices, hospitals, shopping areas or universities
• G05D 109/10 - Land vehicles
• G05D 111/10 - Optical signals

Abstract

A method for efficiently performing a process configuration where information of multiple users may be kept secret from each other. A neural network trained to map process inputs to process outputs is converted to operate on data in the encrypted domain of a predetermined encryption and decryption scheme such that the encryption of the encryption and decryption scheme is homomorphic with respect to the operation of the converted neural network. Furthermore, a desired process output in the encrypted domain is determined. Additionally, an input in the encrypted domain to the converted neural network leading to an output of the converted neural network approximating the desired process output in the encrypted domain is determined. The determined input is then provided for configuration of the process.

IPC Classes  ?

• G06N 3/084 - Backpropagation, e.g. using gradient descent
• G06N 3/048 - Activation functions
• H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols
• H04L 9/08 - Key distribution

Abstract

Immune cells comprising modification to increase the expression or activity of SERPINB9 are disclosed. Also disclosed are compositions comprising such cells and methods of using such cells and compositions.

IPC Classes  ?

• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 40/42 - Cancer antigens
• A61P 35/00 - Antineoplastic agents
• C07K 14/81 - Protease inhibitors
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

A device for peritoneal dialysis comprising: a receptacle at least partially defined by a biocompatible semi-permeable membrane, the receptacle configured to allow a dialysate to be flowed into the receptacle and to hold therein the dialysate when the receptacle is in a peritoneal cavity of a patient, the receptacle further configured to allow the dialysate to be removed from the receptacle; wherein the membrane is configured to prevent passage of glucose through the membrane while allowing passage of fluid including waste products from the patient's blood through the membrane.

IPC Classes  ?

• A61M 1/28 - Peritoneal dialysis
• A61M 25/10 - Balloon catheters
• B01D 61/24 - Dialysis
• B01D 63/02 - Hollow fibre modules

Abstract

This document describes a two-dimensional discrete Fourier transform (DFT) hardware accelerator comprising an ultrasonic transmitter configured to convert input signals to I/Q ultrasonic waves which are then transmitted to a lens, and an ultrasonic receiver configured to receive and convert ultrasonic waves to baseband signals, whereby the lens is provided between the transmitter and the receiver, and whereby the I/Q ultrasonic waves transmitted by the transmitter will superimpose on the lens before being received by the receiver.

IPC Classes  ?

• H04B 11/00 - Transmission systems employing ultrasonic, sonic or infrasonic waves

Abstract

Method and system for localising a robot 100 using a scale plan of a designated environment are provided herein. In an embodiment, the method comprises: identifying reference features from the scale plan 136; generating a predicted pose 156 of the robot's current location on the scale plan 136 based on the identified reference features; scanning on-site reference features 186 of the current location; generating a map 158 for the current location to localise the robot 100, based on the scanned on-site reference features 186 of the current location and last N frames of historical scans of previous on-site reference features 186 of a plurality of locations in the designated environment that the robot traversed through before reaching the current location; the last N frames being fewer than total frames of the historical scans of the previous on-site reference features 186.

IPC Classes  ?

• G01C 21/00 - NavigationNavigational instruments not provided for in groups
• G01C 21/30 - Map- or contour-matching
• G01S 17/89 - Lidar systems, specially adapted for specific applications for mapping or imaging