C S Bio Co.

United States of America

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        Patent 4
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Date
2024 1
2023 1
2021 1
Before 2020 2
IPC Class
B01F 29/20 - Mixers with rotating receptacles with receptacles rotating about an axis at an angle to their longitudinal axis 2
B01F 29/60 - Mixers with rotating receptacles rotating about a horizontal or inclined axis, e.g. drum mixers 2
B01F 35/52 - Receptacles with two or more compartments 2
B01F 35/53 - Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components 2
B01J 19/28 - Moving reactors, e.g. rotary drums 2
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Status
Pending 2
Registered / In Force 3

1.

GYM IN A VIAL

      
Serial Number 98861989
Status Pending
Filing Date 2024-11-19
Owner C S Bio Co. ()
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Cardiovascular pharmaceutical preparations; Pharmaceutical preparations for the prevention of cardiovascular health

2.

OLIGONUCLEOTIDE SYNTHESIZER

      
Application Number 18055579
Status Pending
Filing Date 2022-11-15
First Publication Date 2023-03-09
Owner C S Bio Co. (USA)
Inventor
  • Slavazza, Dario
  • Chang, Heng Wei
  • Chang, Yoheng Hanson

Abstract

A process for making an oligonucleotide, the process including reacting a oligonucleotide precursor with a solid phase support within a reaction vessel, the reaction vessel being coupled to an actuator and having a resting position and inverting the reaction vessel via the actuator such that the reaction vessel is inverted relative to the resting position, wherein the inversion of the reaction vessel results in stirring of the solid phase support within the reaction vessel.

IPC Classes  ?

  • C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
  • C07H 1/00 - Processes for the preparation of sugar derivatives
  • B01F 29/20 - Mixers with rotating receptacles with receptacles rotating about an axis at an angle to their longitudinal axis
  • B01F 35/53 - Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
  • B01J 19/28 - Moving reactors, e.g. rotary drums
  • B01F 29/60 - Mixers with rotating receptacles rotating about a horizontal or inclined axis, e.g. drum mixers
  • B01F 35/52 - Receptacles with two or more compartments

3.

Oligonucleotide synthesizer

      
Application Number 17005854
Grant Number 11524976
Status In Force
Filing Date 2020-08-28
First Publication Date 2021-03-04
Grant Date 2022-12-13
Owner C S Bio Co. (USA)
Inventor
  • Slavazza, Dario
  • Chang, Heng Wei
  • Chang, Yoheng Hanson

Abstract

A process for making an oligonucleotide, the process including reacting a oligonucleotide precursor with a solid phase support within a reaction vessel, the reaction vessel being coupled to an actuator and having a resting position and inverting the reaction vessel via the actuator such that the reaction vessel is inverted relative to the resting position, wherein the inversion of the reaction vessel results in stirring of the solid phase support within the reaction vessel.

IPC Classes  ?

  • B01F 29/20 - Mixers with rotating receptacles with receptacles rotating about an axis at an angle to their longitudinal axis
  • B01F 35/53 - Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
  • B01J 19/28 - Moving reactors, e.g. rotary drums
  • B01F 29/60 - Mixers with rotating receptacles rotating about a horizontal or inclined axis, e.g. drum mixers
  • B01F 35/52 - Receptacles with two or more compartments
  • C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
  • C07H 1/00 - Processes for the preparation of sugar derivatives

4.

RAPID PEPTIDE SYNTHESIS AT ELEVATED TEMPERATURES

      
Application Number US2017052099
Publication Number 2018/057470
Status In Force
Filing Date 2017-09-18
Publication Date 2018-03-29
Owner C S BIO CO. (USA)
Inventor
  • Slavazza, Dario
  • Chang, Heng, Wei
  • Chang, Jason
  • Wang, Wei

Abstract

Methods for rapid solid phase peptide synthesis (SPPS) at elevated temperatures are provided. The methods of the invention shorten the time required for peptide synthesis significantly, while still providing crude peptide in good yield, purity, and stereochemical purity.

IPC Classes  ?

  • C07K 1/08 - General processes for the preparation of peptides using protecting groups or activating agents using activating agents
  • C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
  • C07K 1/04 - General processes for the preparation of peptides on carriers

5.

METHODS OF PREPARING PEPTIDES

      
Application Number US2017029969
Publication Number 2017/189925
Status In Force
Filing Date 2017-04-27
Publication Date 2017-11-02
Owner C S BIO CO. (USA)
Inventor
  • Wang, Wei
  • Chang, Jason
  • Slavazza, Dario
  • Chang, Heng, Wei

Abstract

The present invention provides methods of preparing a peptide having an N-terminal histidine, and compositions comprising a plurality of peptides prepared by the methods. The methods disclosed herein reduce racemization of the N-terminal histidine in the peptides during the synthesis process, thereby improving the yield and purity of the peptide compositions. Exemplary peptides that can be manufactured with the methods include Exenatide, Lixisenatide, and Liraglutide.

IPC Classes  ?

  • C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
  • C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
  • C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
  • A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
  • A61K 38/26 - Glucagons