A cell suction holding pipette includes a hollow body and a lumen having a leading end opening and a rear end opening. The hollow body includes a leading end portion, and the leading end portion includes an inclined surface portion formed on an outer surface of the leading end portion and inclining toward a leading end side extension line of a central axis of the lumen.
An oocyte retrieval needle includes: a hollow needle that includes a puncture blade surface; a hollow grip that includes an indicator protrusion portion that is related to an orientation of the puncture blade surface; and a cylindrical cover portion that covers a portion including the indicator protrusion portion. An embryo transfer instrument includes: a flexible tube that includes a tip end curved portion; and a hollow grip. The hollow grip includes: an indicator protrusion portion that is related to a curved direction of the flexible tube; and a cylindrical cover portion that covers a portion including the indicator protrusion portion. The cylindrical cover portions have high static friction property, transparency, and flexibility. The indicator protrusion portions are visually and tactilely recognizable from an outside of the cylindrical cover portions.
An organ prolapse preventing ring for intravaginal insertion includes a ring-shaped portion constituted by a frame portion having a circular cross section. The ring-shaped portion includes a ring body formed of a soft material and four arcuate reinforcing members and formed of a hard or semi-hard material and embedded in the ring body. The ring-shaped portion includes a first bendable portion composed of a first pair of arcuate-reinforcing-member absent portions and formed of only the soft material and facing each other, and a second bendable portion composed of a second pair of arcuate-reinforcing-member absent portions that are formed of only the soft material, orthogonal to the first pair of arcuate-reinforcing-member absent portions, and face each other.
A pipette 1 for suctioning/holding cells is provided with a hollow body part 2 and a lumen part 3 having a front-end opening part 31 and a back-end opening part 32, wherein the hollow body part 2 is provided with a tip end part 21, and the tip end part 21 has an inclined surface part 4 that is formed on the outer surface of the tip end part 21 and is inclined toward a tip-side extension line of a center axis of the lumen part 3.
A plate for biological cell processing operation has a plate body and a lid. The plate body has an upper surface portion, a base portion, an annular wall portion extending above the base portion, a recess inside the annular wall portion, cell processing solution in the recess, and a sealing sheet sealing the recess. The lid covers the annular wall portion and recess of the plate and is placed over the base portion. The sealing sheet has a sheet body portion sealing the recess and a gripping portion for peeling. In the lid attached state, the gripping portion for peeling passes between the annular wall portion and the lid and is close to an upper surface portion of the base portion, while in the lid unattached state, the gripping portion for peeling rises up and away from the upper surface portion.
An oocyte collection needle 1 comprises a hollow needle 2 having a puncture blade surface 23, a hollow grip 3 having an indicating protrusion 34 associated with the direction of the puncture blade surface, and a tubular covering part 33 covering a part including the indicating protrusion 34. An embryo transfer instrument 10 comprises a flexible tube 6 having a curved tip, and a hollow grip 7. The hollow grip 7 comprises an indicating protrusion 74 associated with the curved direction of the flexile tube 6, and a tubular covering part 73 covering a part including the indicating protrusion 74. The tubular covering parts 33 and 73 have high static friction, transparency and flexibility. The indicating protrusions can be visually and tactilely recognized from outside the tubular covering parts.
A ring 1 for preventing organ prolapse, which is to be inserted into the vagina, has a ring-shaped part 2 comprising a circular cross-sectional skeleton, wherein the ring-shaped part has a ring body 21 made of a soft material and four arc-shaped reinforcing members 3a, 3b, 3c and 3d which are made of a hard or semi-hard material and buried inside the ring body. The ring-shaped part 2 has a first bendable part 51 configured of a first set of arc-shaped reinforcing member-free parts 5a and 5c that are formed of a soft material alone and face to each other, and a second bendable part 52 configured of a second set of arc-shaped reinforcing member-free parts that are formed of a soft material alone and face to each other in the direction orthogonal to the first set of the arc-shaped reinforcing member-free parts 5a and 5c.
This biological cell freezing/preservation instrument 1 is provided with: four bottomed tubes 3 (3a, 3b, 3c, 3d); a cane 2 provided with holding units 11, 12, 13, 14 for the bottomed tubes; and a plurality of biological cell freezing/preservation tools 4. The cane 2 holds the four bottomed tubes in series at approximately regular intervals. Each of the biological cell freezing/preservation tools 4 is configured such that, when a tubular member 50 is attached to a rod-shaped main body part 41, the entire length is shorter than a distance L1 between outer bottom surfaces of adjacent bottomed tubes. An upper end opening 33 of each of the bottomed tubes is an inclined opening that descends toward the front end of a cane main body part 21. Each of the biological cell freezing/preservation tools 4 is also configured such that, when each of the biological cell freezing/preservation tools 4 is placed in the bottomed tube with the tubular member 50 arranged downward, the upper part of the rod-like main body part 41 is exposed.
A biological sample storage container includes a biological sample storage tube and a biological sample storage tube cap. The tube cap is a cap that is to be attached to the tube having a lower closed portion and an upper opening portion, and is for closing the upper opening portion. The tube cap includes a main body portion that enters the upper opening portion of the biological sample storage tube and closes the upper opening portion, an elongated biological sample adhering portion that extends downward from a lower face of the main body portion, and a flange that protrudes laterally outward from the main body portion. The biological sample adhering portion is cuttable and falls into the biological sample storage tube after being cut.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
C12M 1/00 - Apparatus for enzymology or microbiology
A biological cell processing work plate 1a comprises a plate body 2a and a lid 3a. The plate body comprises: a base 5a including a top surface 52a; an annular wall 6a that extends upward from the base 5a; a recess 8 on the inside of the annular wall 6a; a cell processing liquid in the recess; and a sealing sheet 4 that seals the recess. The lid covers the annular wall and the recess of the plate, and is placed on the base. The sealing sheet 4 comprises a sheet body 41 that seals the recess, and a for-detachment holding part 42. In a state where the lid is mounted, the for-detachment holding part passes between the annular wall and the lid and approaches the top surface 52a of the base; and in a state where the lid is not mounted, the for-detachment holding part rises upward and separates from the top surface 52a.
An intrauterine tissue collecting instrument includes a flexible outer tube, a flexible inner tube within the outer tube, and a shaft member within the inner tube. The flexible outer tube includes an outer tube distal end portion that can be open at at least three slits 4. The flexible inner tube includes an inner tube distal end portion including a plurality of side openings. The shaft member includes a diameter-expanded distal end portion. The intrauterine tissue collecting instrument can collect intrauterine tissue through suction in a state where the inner tube protrudes from the outer tube within the uterus. The inner tube distal end portion can be housed again in the flexible outer tube within the uterus.
A cell cryopreservation pretreatment operation plate includes a planar operation portion, a first recess for storing a treatment solution, a second recess for storing a treatment solution, a third recess for storing a treatment solution, and a fourth recess for storing discarded solutions. The planar operation portion includes, on a surface thereof, a first circular segment, second circular segment, and third circular segment for placing treatment solutions, an enlarged first circular segment enclosing the first circular segment, an enlarged second circular segment enclosing the second circular segment, and an enlarged third circular segment enclosing the third circular segment.
A biological sample storage container 10 is equipped with: a biological sample storage tube 6; and a biological sample storage tube cap 1. The tube cap 1 is attached to the tube 6 having a lower closed part 66 and an upper opening part 63, and is used for closing the upper opening part 63. The tube cap 1 is equipped with: a main body part 3 which enters the upper opening part 63 of the biological sample storage tube 6 to close the upper opening part 63; a biological sample attaching part 2 which is long and thin and extends downward from the lower surface of the main body part 3; and a flange 5 which protrudes outward in the side surface direction from the main body part 3. The biological sample attaching part 2 is configured cuttable so as to fall down into the biological sample storage tube 6 after being cut.
When transplanting a plurality of ovarian tissue fragments, agglomeration of ovarian tissue fragments is prevented, angiogenesis is promoted, and engraftment rate is improved. When transplanting a plurality of ovarian tissue fragments formed by cutting ovarian tissue into a mammal, and the ovarian tissue fragments are transplanted by an injection step in which collagen gel is injected into a site to be transplanted, using collagen gel with a gel concentration of about 1%, and then a transplantation step in which the plurality of ovarian tissue fragments are inserted into the collagen gel. At this time, each of the plurality of ovarian tissue fragments may be previously encapsulated with the collagen gel.
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
An embryo transfer tool has a flexible tube and a hub. The flexible tube has first and second microparticle-containing synthetic resin portions. The first and second microparticle-containing synthetic resin portions are not exposed in outer and inner surfaces of the flexible tube, and are formed by a synthetic resin and a large number of hollow glass beads having a diameter of 0.5 to 200 μm. The hollow glass beads are dispersed in the synthetic resin. The first and second microparticle-containing synthetic resin portions include a large number of boundary surfaces that are formed between the synthetic resin and the hollow glass beads.
This cell cryopreservation pretreatment operation plate 1 is provided with a tabular operation part 2, a first recessed part 14 for accommodating a treatment solution therein, a second recessed part 15 for accommodating a treatment solution therein, a third recessed part 16 for accommodating a treatment solution therein, and a fourth recessed part 18 for accommodating a waste treatment solution therein. The surface of the tabular operation part 2 has, in order to hold a treatment solution, a first circular compartment 21, a second circular compartment 22, a third circular compartment 23, an expanded first circular compartment 61 enclosing the first circular compartment 21, an expanded second circular compartment 62 enclosing the second circular compartment 22, and an expanded third circular compartment 63 enclosing the third circular compartment 23.
An intrauterine tissue collection instrument 1 is provided with: a flexible outer tube 2; a flexible inner tube 3 capable of moving in the axial direction inside the outer tube; and a shaft member 4 capable of moving in the axial direction inside the inner tube. The flexible outer tube is provided with an outer tube distal end section that can be opened at at least three slits 24 provided at a substantially hemispherical distal end. The flexible inner tube is provided with an inner tube distal end section 33 having a plurality of side openings 34a, 34b, 35a, 35b. The shaft member 4 is provided with an increased diameter distal end section 45 that slides inside the inner tube in a liquid-tight manner. The flexible inner tube 3 can protrude from the outer tube by being pressed into the inside and expanding the slits. Intrauterine tissue 5 can be sucked and collected from the side openings by moving the shaft member 4 to the proximal side. Within the uterus, the inner tube distal end section 33 can be re-stored inside the flexible outer tube.
The embryo transplanting tool 1 has a soft tube 11 and a hub 12. The soft tube 11 is provided with a first fine particle-containing portion 13a extending at a predetermined width over a predetermined length from the leading end portion to the base end, a second fine particle-containing portion 13b facing the first fine particle-containing portion 13a, and first and second colorless transparent portions 15a, 15b located between the first fine particle-containing portion 13a and the second fine particle-containing portion 13b. The first and second fine particle-containing portions are located within the soft tube inner walls and unexposed. The first and second fine particle-containing portions each comprise a multitude of fine particles 14 formed from a synthetic resin and a material different from the synthetic resin and have a multitude of boundary surfaces formed by the synthetic resin and the intervals between the fine particles.
The present invention prevents clumping of ovarian tissue fragments, promotes angiogenesis, and improves take rate when transplanting a plurality of ovarian tissue fragments. When transplanting a plurality of ovarian tissue fragments, formed by thinly slicing ovarian tissue, to a mammal, the ovarian tissue fragments are transplanted via an injection step of injecting a collagen gel having a gel concentration of approximately 1% into the scheduled transplantation site, and a transplantation step of subsequently inserting the plurality of ovarian tissue fragments into the collagen gel. At such time, the plurality of ovarian tissue fragments may each be encapsulated in collagen gel in advance.
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
A61P 43/00 - Drugs for specific purposes, not provided for in groups
22.
Instrument for fixedly transplanting living body embryo into uterus
ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE (Japan)
KITAZATO CORPORATION (Japan)
Inventor
Ikeuchi, Masashi
Kawamura, Kazuhiro
Inoue, Futoshi
Abstract
An instrument for fixedly transplanting a living body embryo into a uterus has an instrument, for transplanting the living body embryo into the uterus, which is to be inserted into a uterus and a magnetic embryo accommodation container holding instrument (transferred embryo fixing instrument) to be attached to the living body. The instrument for transplanting the living body embryo into the uterus has an embryo accommodation container having an embryo accommodation part having an embryo insertion portion communicating with outside and a magnetic material and a shaft-shaped container transfer tool for separably holding the embryo accommodation container at its distal end portion. The magnetic container holding instrument has an attaching part to be attached to an epidermis of the living body and a magnet capable of attracting the magnetic material of the embryo accommodation container thereto.
A culture medium protective liquid material of the present invention covers a culture medium when a living cell is cultured. The culture medium protective liquid material contains liquid paraffin which is liquid at room temperature as a main component thereof and an antioxidative substance for restraining the liquid paraffin from being oxidized.
A living cell transplanting device has a flexible tube capable of accommodating living cells and a cell pushing shaft inserted into the tube. The tube has a lumen penetrating therethrough and a reduced diameter front end open portion. The shaft has a small diameter end portion having a diameter smaller than that of the reduced diameter front end open portion and an enlarged diameter portion having an outer diameter larger than an inner diameter of reduced diameter front end open portion. Owing to contact between the enlarged diameter portion of the shaft and the reduced diameter front end open portion of the tube, a progress of the shaft is regulated. By pushing the shaft into the tube after the contact between the enlarged diameter portion and the reduced diameter front end open portion finishes, the enlarged diameter portion of the shaft passes through said reduced diameter front end open portion with expanding the reduced diameter front end open portion of the tube and projects beyond the reduced diameter front end open portion of the tube.
This biological cell cryopreservation tool 1 is equipped with a main body portion 2 formed from a cold-resistant material and a biological cell holding portion 3 formed from a cold-resistant material. The biological cell holding portion 3 is equipped with an optically transparent base portion 31 and a water-absorbing portion 32 secured to the surface of the base portion 31. The water-absorbing portion 32 is equipped with a missing portion 33 surrounded by the water-absorbing portion 32. The surface of the base portion 31 is exposed in the missing portion 33, and the missing portion is optically transparent.
A frozen biological cell pellet preparation device 1 comprises: a device body 2 comprising a funnel part 20 that decreases in diameter toward a sampling container connection opening 24, and legs 31a, 31b, 31c; and a plate-shaped member 4 housed within the upper part of the funnel part 20. The funnel part 20 comprises a plurality of side holes 26, and the plate-shaped member 4 comprises a plurality of through-holes 42. The device body 2 and plate-shaped member 4 are submerged in liquid nitrogen, in which state a biological-cell-containing liquid is introduced dropwise from above the plate-shaped member 4, thereby forming frozen biological cell pellets in the through-holes 42 of the plate-shaped member 4. The frozen biological cell pellets descend through the funnel part and are guided into the sampling container connection opening 24.
A needle employs a three-stair-stepped structure including a front-end small diameter part, an intermediate part, and a large diameter part. The front-end small diameter part and the intermediate part are in fluid communication with each other by a first tapered part, and the intermediate part and the large diameter part are in fluid communication with each other by a second tapered part. The internal diameter of the front-end small diameter part is made so as to be equal to or greater than 0.35 mm based on the allowable deformation level of a cumulus oocyte complex, the outer diameter is made so as to be equal to or smaller than 0.7 mm based on the size of a small follicle, and the inclination angle of the inclined acicular end, and the length is made so as to be 10-25 mm based on the size of a dominant follicle.
ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE (Japan)
KITAZATO CORPORATION (Japan)
Inventor
Ikeuchi Masashi
Kawamura Kazuhiro
Inoue Futoshi
Abstract
A fixing instrument 10 for intrauterine implantation of vital embryo comprises: a vital embryo intrauterine implantation tool 1 which is to be inserted into the uterus; and a magnetic holder 6 for embryo housing container (an embryo implant fixing tool) which is to be attached to a living body. The vital embryo intrauterine implantation tool 1 comprises: an embryo housing part 42 provided with an embryo inserting part 44 which is communicated with outside; an embryo housing container 4 provided with a magnetic body 43; and a shaft-shaped container transfer tool 5 which detachably holds the embryo housing container 4 at the tip thereof. The magnetic holder 6 for embryo housing container is provided with: a mounting part 63 which is to be mounted to the skin surface of the living body; and a magnet 62 which is capable of attracting the magnetic body 43 in the embryo housing container 4.
A living cell transplanting tool (1) is provided with a flexible tube (2) capable of accommodating living cells (12), and a cell pushing-out shaft (3) which is inserted into the tube (2). The tube (2) is provided with a penetrating lumen (24) and a diametrically contracted tip end opening portion (23). The shaft (3) is provided with a small-diameter tip end portion (32) having a smaller diameter than the diametrically contracted tip end opening portion (23), and an enlarged diameter portion 33 having a larger diameter than the diametrically contracted tip end opening portion (23). Insertion progress of the shaft (3) is restricted by the enlarged diameter portion (33) of the shaft (3) coming into contact with the diametrically contracted tip end opening portion (23) of the tube (2), and after the two have come into contact with one another, by the shaft (3) being pushed in, the enlarged diameter portion (33) causes the diametrically contracted tip end opening portion (23) to widen by being pushed, passes through the same, and protrudes from the diametrically contracted tip end opening portion (23) of the tube (2).
ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE (Japan)
Inventor
Suzuki, Nao
Sugishita, Yodo
Inoue, Futoshi
Abstract
A collected living tissue cryopreserving tool is composed of a tissue piece holder and a resin-made accommodating bag. The tissue piece holder is composed of a plate-shaped body part including a thermally conductive plate-shaped lower member and a plate-shaped upper member and a covering sheet held by the plate-shaped body part. The tissue piece holder has a tissue piece placing part formed of a cut-out part provided on the plate-shaped upper member and a part, of an upper surface of the thermally conductive plate-shaped lower member, which is disposed at the cut-out part. The covering sheet is capable of covering the tissue piece placing part.
An instrument 1 for embryo transplantation is provided with a soft tube 11 and a hub 12. The soft tube 11 is provide with: a first bubble-containing surface layer 13a having a predetermined width and extending by a predetermined length from a tip end toward a base end; a second bubble-containing surface layer 13b facing the first bubble-containing surface layer 13a; and first and second colorless transparent sections 15a, 15b located between the first bubble-containing surface layer 13a and the second bubble-containing surface layer 13b. The first and second bubble-containing surface layers contain a large number of bubbles 14 that are long in the axial direction of the soft tube. The first and second bubble-containing surface layers have a thickness which is 1/5-1/3 of the wall thickness of the soft tube, and a width which is 5/100-20/100 of the outer perimeter of the soft tube.
A needle employs a three-stair-stepped structure including a front-end small diameter part, an intermediate part, and a large diameter part . The front-end small diameter part and the intermediate part are in fluid communication with each other by the first tapered part, and the intermediate part and the large diameter part are in fluid communication with each other by the second tapered part. The internal diameter of the front-end small diameter part is made so as to be equal to or greater than 0.35 mm based on the allowable deformation level of a cumulus oocyte complex, the outer diameter is made so as to be equal to or smaller than 0.7 mm based on the size of a small follicle, and the inclination angle of the inclined acicular end, and the length is made so as to be 10-25 mm based on the size of a dominant follicle. The internal diameter of the intermediate part is made so as to be equal to or greater than 0.45 mm based on the size of the cumulus oocyte complex. The internal diameter of the first tapered part is formed at an average gradient of equal to or smaller than 10% so as to suppress an abrupt recovery of the cumulus oocyte complex from a deformed condition at the time of suction, and the total length from the front-end small diameter part to the intermediate part is made so as to be a length that does not allow the large diameter part to be inserted in human tissue.
A needle is formed in a three-part structure composed of a small-diameter tip part, a middle part and a large-diameter part, wherein the small-diameter tip part is fluid-communicated with the middle part through a first taper part and the middle part is fluid-communicated with the large-diameter part through a second taper part, the small-diameter tip part is so formed that the inner diameter is set at 0.35 mm or more on the basis of the allowable deviation of a cumulus cell, the outer diameter is set at 0.7 mm or less on the basis of the size of a small follicle and the inclination angle of an inclined tip and the length is set at 10 to 25 mm on the basis of the size of a dominant follicle, the inner diameter of the middle part is set at 0.45 mm or more on the basis of the size of a cumulus cell, the inner diameter of the first taper part is so set as to have an average grade of 10% or less in order to prevent the rapid deformation recovery of an oocyte-cumulus cell complex during suction, and the total length between the small-diameter tip part and the middle part is so set that the large-diameter part cannot penetrate through a tissue of a human body.
A living cell collection needle has a hollow needle having a hollow body part, a hollow small-diameter front end part, a tapered part between the front end part and the hollow body part and decreasing in inner and outer diameters toward the front end of the needle, and a piercing cutting edge part at a front end of the small-diameter front end part; a hub fixed to a rear end portion of the hollow body part; an inner tube inside the hollow needle and a living cell sucking tube connected to a rear end portion of the inner tube. A rear end of the hollow needle is positioned inside the hub. The needle has a side tube with a front end portion inside the hub and communicating with the inside of the hollow needle and a rear end portion projecting rearward from the hub and liquid-tightly fixed to the hub.
Medical equipment, [, namely, a vitrification kit for oocytes, embryos or other biological cells, comprised of vitrification devices and synthetic media, namely, vitrification and thawing solutions; medical equipment, ], namely, a vitrification device for oocytes and embryos
Medical equipment, [, namely, a vitrification kit for oocytes, embryos, or other biological cells, comprised of vitrification devices and synthetic media, namely, vitrification and thawing solutions; medical equipment, ], namely, a vitrification device for oocytes and embryos
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Vitrification media for oocyte and embryo; vitrification
media for biological cell; cryopreservation media for oocyte
and embryo; cryopreservation media for biological cell;
culture medium for biological cell; sperm preparation media;
sperm freezing media; culture medium for medical purposes;
chemical reagents for medical or veterinary purposes; drugs
for medical purposes. Vitrification kit for oocyte and embryo; vitrification kit
for biological cell; cryopreservation device for oocyte and
embryo; cryopreservation device for biological cell; device
for in vitro fertilization; catheters; oocyte retrieval
needle; biological cell sampling needle; medical apparatus
and instruments. Oocyte and embryo vitrification services for artificial
insemination; oocyte and embryo cryopreservation services
for artificial insemination; sperm freezing services for
artificial insemination; in vitro fertilization services;
artificial insemination services; medical clinic services;
providing medical information.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Vitrification media for oocyte and embryo; vitrification
media for biological cell; cryopreservation media for oocyte
and embryo; cryopreservation media for biological cell;
culture medium for biological cell; sperm preparation media;
sperm freezing media; culture medium for medical purposes;
chemical reagents for medical or veterinary purposes; drugs
for medical purposes. Vitrification kit for oocyte and embryo; vitrification kit
for biological cell; cryopreservation device for oocyte and
embryo; cryopreservation device for biological cell; device
for in vitro fertilization; catheters; oocyte retrieval
needle; biological cell sampling needle; medical apparatus
and instruments. Oocyte and embryo vitrification services for artificial
insemination; oocyte and embryo cryopreservation services
for artificial insemination; sperm freezing services for
artificial insemination; in vitro fertilization services;
artificial insemination services; medical clinic services;
providing medical information.
