Abstract

The invention disclosed herein relates to compositions for coating a surface to provide a release of antimicrobial active agents from said surface, to coatings formed using said compositions, and to medical devices comprising said coatings.

IPC Classes  ?

• A61L 27/28 - Materials for coating prostheses
• A61L 29/08 - Materials for coatings
• A61L 31/08 - Materials for coatings
• A61K 31/194 - Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• A61P 31/04 - Antibacterial agents
• A61K 31/44 - Non-condensed pyridines; Hydrogenated derivatives thereof
• A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group

Abstract

n   (1)

IPC Classes  ?

• C07C 69/76 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
• C07C 15/52 - Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic part substituted by unsaturated hydrocarbon radicals polycyclic non-condensed containing a group with formula
• C07C 1/32 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero atoms other than, or in addition to, oxygen or halogen
• C07C 67/343 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by change of size of the carbon skeleton by increase in the number of carbon atoms
• A61P 31/04 - Antibacterial agents
• C07C 2/68 - Catalytic processes with halides
• C07C 2/70 - Catalytic processes with acids
• C07C 5/09 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation of carbon-to-carbon triple bonds to carbon-to-carbon double bonds
• C07C 7/10 - Purification, separation or stabilisation of hydrocarbons; Use of additives by extraction, i.e. purification or separation of liquid hydrocarbons with the aid of liquids
• C07C 15/46 - Styrene; Ring-alkylated styrenes
• C07C 25/28 - Halogenated styrenes

Abstract

Novel aryl compounds or pharmaceutically acceptable salts thereof, and uses of the same for the treatment of Gram-negative infections.

IPC Classes  ?

• C07C 211/27 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
• A61K 31/14 - Quaternary ammonium compounds, e.g. edrophonium, choline
• A61P 31/04 - Antibacterial agents

Abstract

The present invention provides a composition comprising a combination of: (i) at least one aryl antibiotic comprising a compound having a structure selected from Group I, or a pharmaceutically acceptable salt thereof; and (ii) at least one antibiotic selected from the list comprising a penicillin or a derivative thereof, a cepham or a derivative thereof, vancomycin, linezolid, daptomycin and mupirocin.

IPC Classes  ?

• A61K 31/194 - Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
• A61K 31/44 - Non-condensed pyridines; Hydrogenated derivatives thereof
• A61P 31/04 - Antibacterial agents

Abstract

A method for the synthesis of a aryl compound of Formula (1). Formula (1)

IPC Classes  ?

• C07C 2/64 - Addition to a carbon atom of a six-membered aromatic ring
• C07C 2/66 - Catalytic processes
• C07C 69/612 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
• C07C 69/614 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety of phenylacetic acid

Abstract

A compound for use as an antimicrobial having a formula (A).

IPC Classes  ?

• C07C 309/00 - Sulfonic acids; Halides, esters, or anhydrides thereof
• C07C 69/76 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
• A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
• A61K 31/194 - Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• A61K 31/444 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A01N 37/10 - Aromatic or araliphatic carboxylic acids, or thio-analogues thereof; Derivatives thereof
• C07C 63/331 - Polycyclic acids with all carboxyl groups bound to non-condensed rings
• C07C 63/66 - Polycyclic acids with unsaturation outside the aromatic rings