09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Electronic publications (downloadable), including brochures, reports, brochures, booklets, magazines, leaflets, magazines, journals, teaching and educational materials in the field of clinical, medical, pharmaceutical or clinical or medical diagnostic research and development, clinical, medical, pharmaceutical or clinical or medical diagnostic science, clinical tests, clinical or medical diagnostics, medicine, medicines, medical disorders, medical diseases, clinical or medical treatment and prevention; application software for mobile devices (APP) for information and interaction and clinical, medical, pharmaceutical or clinical or medical diagnostic purposes; electronic publications (downloadable) related to the assessment of cognitive functions; application software for mobile devices for the assessment of cognitive functions; downloadable software for the assessment of cognitive functions Educational services; teaching services; arranging and conducting of seminars, conferences, symposiums, workshops (training) and courses; educational and teaching services in the field of research and development, science, clinical tests, diagnostics, medicine, medical devices, disorders, diseases, treatment, prevention and related to the assessment of cognitive functions; educational and teaching services in the field of research and development, science, clinical tests, diagnostics, medicine, medical devices, disorders, diseases, treatment, prevention and related to the assessment of cognitive functions, provided electronically, online, via cable or the Internet or other electronic media; arranging and conducting of expert forums, including online; online educational programs; providing online publications (non-downloadable), including brochures, reports, pamphlets, booklets, magazines, leaflets, journals, teaching and educational materials in the fields of research and development, science, clinical testing, diagnostics, medicine, teaching aids, disorders, diseases, treatment, prevention and related to the assessment of cognitive functions; providing educational assessments of cognitive functions via online non-downloadable screening tools Pharmaceutical research and development; scientific and technological services and research in the field of medical disorders, medical diseases and medical prevention; scientific and technological services and research in the field of the central nervous system and central nervous system-related disorders, diseases and medicines; medical research and testing; clinical research and testing; diagnostic research and testing; providing online non-downloadable screening tools (software) for assessing cognitive functions Medical and therapeutic services and healthcare and medical services, including clinical healthcare and clinical medical services; medical, clinical, therapeutic and health information services; services in the field of psychiatry and psychology and disorders and diseases of the central nervous system; advice in relation to medical and pharmaceutical preparations and substances; healthcare and medical services in relation to disorders, diseases and medicines related to the central nervous system and neurological disorders, diseases and medicines; provision of educational and medical information in the field of diagnostics, medicines, medicines, disorders, diseases, treatment and prevention; provision of online medical data and analysis designed to provide patients and clients with tailored information, including on medical dosages, diagnoses, therapeutic topics and medical administration
The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C07K 14/72 - ReceptorsCell surface antigensCell surface determinants for hormones
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K 16/26 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C07K 16/42 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against immunoglobulins (anti-idiotypic antibodies)
The present invention relates to novel spiro-macrocyclic compounds of general formula (I) which are Orexin 2 receptor agonists.
The present invention relates to novel spiro-macrocyclic compounds of general formula (I) which are Orexin 2 receptor agonists.
A61K 31/429 - Thiazoles condensed with heterocyclic ring systems
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
The present invention relates to a composition comprising Eptinezumab and LuAG09222. The composition can be used for treating or preventing e.g., headache, pain, migraine, cluster headache or endometriosis.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations and substances for the prevention and treatment of disorders and diseases in, generated by or acting on the central nervous system; pharmaceutical preparations and substances acting on the central nervous system; central nervous system stimulants; pharmaceutical preparations and substances for the prevention and treatment of psychiatric and neurological disorders and diseases; pharmaceutical preparations and substances for the prevention of depression, cognitive impairment, cognitive disorders and diseases, mood disorders, psychosis, anxiety and apathy
6.
COMPOSITIONS AND METHODS FOR TREATING SYNUCLEINOPATHIES
The present invention relates to stable and low viscosity liquid pharmaceutical compositions comprising antibodies binding to human alpha synuclein and to methods for use of antibodies binding to human alpha synuclein for treating synucleinopathies or prodromal synucleinopathy, incl. suitable doses and/or dosing regimens. These antibodies for use in treatment of synucleinopathies or prodromal synucleinopathy may be formulated in the stable and low viscosity liquid pharmaceutical compositions of the invention.
The present invention relates to stable and low viscosity liquid pharmaceutical compositions comprising antibodies binding to human alpha synuclein and to methods for use of antibodies binding to human alpha synuclein for treating synucleinopathies or prodromal synucleinopathy, incl. suitable doses and/or dosing regimens. These antibodies for use in treatment of synucleinopathies or prodromal synucleinopathy may be formulated in the stable and low viscosity liquid pharmaceutical compositions of the invention.
The present invention relates to stable and low viscosity liquid pharmaceutical compositions comprising antibodies binding to human alpha synuclein and to methods for use of antibodies binding to human alpha synuclein for treating synucleinopathies or prodromal synucleinopathy, incl. suitable doses and/or dosing regimens. These antibodies for use in treatment of synucleinopathies or prodromal synucleinopathy may be formulated in the stable and low viscosity liquid pharmaceutical compositions of the invention.
The present invention relates to methods for isolating a product and/or reducing impurities such as Host Cell Proteins (HCP) from a load fluid comprising the product and one or more impurities by passing the load fluid through a medium, followed by at least one wash solution comprising arginine or an arginine derivative at a concentration above about 525 mM and a pH above 8, and collecting the product using an elution solution.
05 - Pharmaceutical, veterinary and sanitary products
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical and veterinary preparations; sanitary preparations for medical use; vaccines; pharmaceutical preparations and substances for the prevention and treatment of disorders and diseases in, generated by or acting on the central nervous system; central nervous system stimulants; pharmaceutical preparations and substances for the prevention and treatment of psychiatric and neurological disorders and diseases; pharmaceutical preparations and substances for the prevention and treatment of Alzheimer's disease and disorder, stroke, depression, mood disorders, psychosis, anxiety, epilepsy, sclerosis, porphyria, Huntington's disease and disorder, insomnia, Parkinson's disease and disorder, schizophrenia, bipolar disorder and disease, ADHD, oncology, pain, alcoholism and dependency; medical preparations, substances, reagents and diagnostic agents for medical purposes Education services; teaching services; arranging and conducting of seminars, conferences, symposia, workshops (education) and courses; educational and teaching activities in the field of research and development, science, clinical trials and tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; educational and training activities in the fields of research and development, science, clinical trials and tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention, provided electronically, online, via cable or the Internet or other electronic media; arranging and holding expert forums, including on-line, in the form of seminars, conferences, symposia, workshops (education) and courses; on-line educational programs; provision of online publications (not downloadable), including books, reports, brochures, booklets, magazines, leaflets, magazines, journals, teaching and training materials in the fields of research and development, science, clinical trials and tests, diagnostics, medicine, pharmaceuticals, disorders , diseases, treatment and prevention Scientific and technological services and research and design relating thereto; industrial analysis and research; providing software and access to data and information in the fields of research and development, science, clinical studies, trials and tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; arranging and holding of expert forums, including on-line, in the fields of research and development, science, clinical studies, experiments and tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; pharmaceutical research and development; scientific and technological services and research in the field of disorders, diseases and prevention; scientific and technological services and research in the field of the central nervous system, neurological disorders and central nervous system related disorders, diseases and drugs; medical research, medical studies, experiments and tests; clinical research, clinical studies, trials and tests; diagnostic research, diagnostic studies, experiments and tests; provision of medical and medical information within research and development, science, clinical studies, trials and tests Medical services; psychiatric and psychological services; consultancy in connection with medical and pharmaceutical preparations; medical clinical services; medical treatment business; therapeutic treatment business; therapeutic clinical services; medical services in connection with disorders, diseases and medicines related to the central nervous system and neurological disorders, diseases and medicines; provision of medical and medical information in the field of diagnostics, medicine, drugs, disorders, diseases, treatment and prevention; medical information service; provision of on-line medical data and analytics designed to provide patients and clients with tailored information, including on medical dosage, diagnoses, therapeutic topics and medical administration.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
38 - Telecommunications services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and medical preparations and substances; pharmaceutical preparations and substances for the prevention and treatment of disorders and diseases in, generated from or acting on the central nervous system; pharmaceutical preparations and substances acting on the central nervous system; central nervous system stimulants; pharmaceutical preparations and substances for the prevention and treatment of psychiatric and neurological disorders and diseases; pharmaceutical preparations and substances for the prevention and treatment of dementia, Alzheimer's disease and disorder, dizziness, seizures, stroke, depression, cognitive impairment, cognitive disorders and diseases, mood swings, psychosis, anxiety, apathy, epilepsy; pharmaceutical preparations and substances for the prevention and treatment of Lennox-Gastaut syndrome (LGS), sclerosis, porphyria, Huntington's disease and disorder, insomnia, Parkinson's disease and disorder, falls, movement disorders and movement disorders, tremor, schizophrenia, bipolar disease and disorder, mania, ADHD, PTSD, agitation, aggression, autism, melancholia, OCD, Tourette's syndrome, progressive supranuclear palsy (PSP), restlessness, akathisia, fatigue, drowsiness, nausea, migraine, pain, alcoholism and addiction; preparations, substances, reagents and agents for diagnostic and medical purposes. Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, leaflets, magazines, journals, teaching and training material in research and development, science, disease information, clinical studies, tests and trials, diagnostics, medicine, pharmaceuticals, medical disorders, medical diseases, clinical or medical treatment and prevention; software for medical and pharmaceutical information, education and sales activities; software for the analysis of medical and pharmaceutical information and disease information; software, including application software for mobile devices (APP); devices and instruments for information and interaction in research and development, science, clinical studies, tests and trials, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; electronic publications (downloadable) related to magazines, journals, teaching and training material in research and development, science, clinical studies, tests and experiments; electronic publications (downloadable) related to diagnostics, medicine, drugs, disorders, diseases, treatment and prevention, downloadable software, including application software for mobile devices (APP); software for use in the diagnosis, management, monitoring, assessment, control and investigation of psychiatric and neurological disorders and diseases, dementia, Alzheimer's disorder and disease, dizziness, convulsions, stroke, depression, cognitive impairment, cognitive disorders and diseases, mood disorders, psychosis, anxiety, apathy, epilepsy, Lennox-Gastaut syndrome (LGS), sclerosis, porphyria, Huntington's disorder and disease, insomnia, Parkinson's disorder and disease, falls, movement disorders and diseases, tremor, schizophrenia, bipolar disorder and disease, mania, ADHD, PTSD , agitation, aggression, autism, melancholia, OCD, Tourette syndrome, progressive supranuclear palsy (PSP), restlessness, akathisia, fatigue, somnolence, nausea, migraine, pain, alcoholism and addiction. Printed publications, including books, reports, brochures, booklets, magazines, leaflets, magazines, journals, teaching and training materials in the field of research and development, science, clinical studies, tests and trials, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention. Providing online forums in the fields of medicines, disease awareness and treatments; providing online chat rooms and electronic message boards for the transmission of messages among users in the field of medicines, disease awareness and treatments. Educational services, namely conducting seminars in the field of pharmaceutical preparations and disease awareness; Provision of education in pharmaceuticals and disease awareness; Arranging and conducting seminars, conferences, symposia, training workshops and courses in the field of medicines and disease awareness; educational activities within pharmaceutical research and development, medical clinical examinations, pharmaceutical tests and trials and diagnostic medicine in connection with the treatment and prevention of diseases and disorders; provision of aforementioned services electronically, online, via cable or internet or other electronic media; arranging and conducting expert forums, namely online training programs in the field of pharmaceutical preparations; providing non-downloadable online publications, namely, books, reports, brochures, pamphlets, leaflets, patient information leaflets, magazines, journals, educational and training materials in the field of pharmaceutical research and development, science, medical clinical studies in the field of pharmaceutical testing and trials, diagnostic medicine, drugs, disorders, disease awareness, treatment and prevention related to assessment of cognitive functions; education in the form of providing cognitive function assessment services through non-downloadable on-line screening tools. Pharmaceutical research and development; scientific and technological services, namely, scientific testing and research related to medical disorders, medical diseases and medical prevention; scientific and technological services, namely, scientific testing and research related to the central nervous system and central nervous system related disorders, pharmaceutical preparations and disease awareness; medical and clinical research, namely pharmaceutical clinical research and conducting clinical trials for others in the field of pharmaceutical preparations; diagnostic research and testing in pharmaceutical research.
13.
PROCESS FOR THE MANUFACTURE OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID
The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and salts thereof.
The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and salts thereof.
The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and salts thereof.
The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.
The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and salts thereof.
The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.
The invention also relates to new intermediates of said process.
The present invention relates the use of monoclonal anti-calcitonin gene-related peptide (CGRP) antagonist antibodies or anti-CGRP receptor antibodies in subjects that do not respond adequately to a first dose but respond to the second dose.
The present invention is directed to compounds of formula (I). These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease.
C07D 498/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
The present invention is directed to compounds of formula (I). These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07D 498/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
The present invention is directed to compounds of formula (I). These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease.
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
The present invention is directed to combination treatment comprising administration of a first compound of formula I which is a Leucine-rich repeat kinase 2 (LRRK2) inhibitor and a second compound, which compound is useful in the treatment of synucleinopathies, such as Parkinson's disease; wherein formula (I) is.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
The present invention is directed to compounds of formula IIa
The present invention is directed to compounds of formula IIa
The present invention is directed to compounds of formula IIa
These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds.
C07D 498/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
20.
TREATMENT OF MEDICATION OVERUSE HEADACHE USING ANTI-CGRP OR ANTI-CGRP-R ANTIBODIES
Methods for treatment or prevention of medication overuse headache are provided. Exemplary methods comprise administration of an anti-CGRP antagonist antibody to a patient in need thereof.
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
38 - Telecommunications services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Pharmaceutical and medicinal preparations and substances; pharmaceutical preparations and substances for the prevention and treatment of disorders and diseases in, generated by or acting on the central nervous system; pharmaceutical preparations and substances, acting on the central nervous system; central nerve system stimulants; pharmaceutical preparations and substances for the prevention and treatment of psychiatric and neurological disorders and diseases; pharmaceutical preparations and substances for the prevention and treatment of dementia, Alzheimer's disease and disorder, dizziness, attack, stroke, depression, cognitive impairment, cognitive disorders and diseases, mood swings, psychosis, anxiety, apathy, epilepsy; pharmaceutical preparations and substances for the prevention and treatment of Lennox-Gastaut syndrome (LGS), sclerosis, porphyria, Huntington's disease and disorder, insomnia, Parkinsons disease and disorder, falls, movement disorders and movement disorders, tremor, schizophrenia, bipolar disorder and suffering, mania, ADHD, PTSD, agitation, aggression, autism, melancholy, OCD, Tourettes syndrome, progressive supranuclear palsy (PSP), restlessness, akathisia, fatigue, drowsiness, nausea, migraine, pain, alcoholism and addiction; compositions, drugs, reagents and agents for diagnostic and medical purposes.
(2) Downloadable electronic publications, namely, books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, journals, teaching and educational material in the field of pharmaceutical research and development, disease awareness, medical clinical studies, pharmaceutical tests and trials, diagnostic medicine, medicine, pharmaceuticals, disorders, diseases, clinical or medical treatment and prevention; software for medical and pharmaceutical information, education and sales activities; software for analyzing medical and pharmaceutical information and disease awareness; software, namely, application software for mobile devices for analyzing medical and pharmaceutical information; apparatus and instruments for analyzing medical and pharmaceutical information in the field of research and development, science, clinical studies, medical clinical tests and trials, diagnostic, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; electronic downloadable publications, namely, magazines, journals, teaching and educational materials in the field of pharmaceutical research and development, science, medical clinical studies, pharmaceutical tests and trials, diagnostic medicine related to clinical or medical treatment and prevention; application software for mobile devices for the assessment of cognitive functions; downloadable software for assessment of cognitive functions; software for use in diagnosing, managing, monitoring, assessing, controlling and examining psychiatric and neurological disorders and diseases, dementia, Alzheimer's disorder and disease, dizziness, seizures, stroke, depression, cognitive impairment, cognitive disorders and diseases, mood disorders, psychosis, anxiety, apathy, epilepsy, Lennox-Gastaut syndrome (LGS), sclerosis, porphyria, Huntington's disorder and disease, insomnia, Parkinson's disorder and disease, falls, movement disorders and diseases, tremor, schizophrenia, bipolar disorder and disease, mania, ADHD, PTSD, agitation, aggression, autism, melancholy, OCD, Tourette's syndrome, progressive supranuclear palsy (PSP), restlessness, akathisia, fatigue, somnolence, nausea, migraine, pain, alcoholism and dependency.
(3) Printed publications, including books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, records, educational and training materials for research and development, science, clinical studies, tests and trials, diagnostics, medicine, drugs, disorders, diseases, treatment and prevention. (1) Arranging and conducting an online forum in the field of pharmaceuticals, disease awareness and treatments; providing online chat rooms and electronic bulletin boards for transmission of messages among users in the field of pharmaceuticals, disease awareness and treatments.
(2) Educational services, namely, conducting seminars in the field of pharmaceuticals and disease awareness; providing of training in the field of pharmaceuticals and disease awareness; arranging and conducting seminars, conferences, symposiums, training workshops and courses in the field of pharmaceuticals and disease awareness; educational training services in the fields of pharmaceutical research and development, medical clinical studies, pharmaceutical tests and trials and diagnostic medicine related to the treatment and prevention of diseases and disorders; providing the aforementioned services electronically, on-line, via cable or Internet or other electronic media; arranging and conducting expert forums, namely, on-line training programs in the field of pharmaceuticals; providing on-line, non-downloadable publications, namely, books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, journals, teaching and educational material in the field of pharmaceutical research and development, science, medical clinical studies in the field of pharmaceutical tests and trials, diagnostic medicine, pharmaceuticals, disorders, disease awareness, treatment and prevention related to the assessment of cognitive functions; providing educational assessment services in the field of cognitive functions through on-line non-downloadable screening tools.
(3) Pharmaceutical research and development; scientific and technological services, namely, scientific testing and research related to medical disorders, medical diseases and medical prevention; scientific and technological services, namely, scientific testing and research related to the central nervous system and central nervous system related disorders, pharmaceuticals and disease awareness; medical and clinical research, namely, pharmaceutical clinical research and conducting clinical trials for others in the field of pharmaceuticals; diagnostic research and tests in the field of pharmaceutical research.
22.
ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS
The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
C07C 235/08 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
C07C 255/44 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
23.
METHOD FOR DETERMINATION OF HYPERPHOSPHORYLATED TAU IN HUMAN CEREBROSPINAL FLUID BY LC-MS
The present invention relates to a method of measuring pS396 Tau in a sample comprising the steps of i-iv, i) Treating a CSF sample from a subject suffering or suspected to be suffering from a Tau pathology with trypsin, ii) Subjecting the sample in step i) to a desphosphorylation agent and subsequently take part of the sample aside for step iv) before proceeding to step iii) with the remaining sample, iii) Subjecting the dephosphorylated sample from step ii) to a second trypsin treatment, iv) Measuring the amount of the Tau peptides (SPVVSGDTSPR) corresponding to Tau residues 396-406 in the samples from step ii) and step iii) using LC-MS.
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
The present invention is directed to a method for treatment of pain, such as hyperalgesia or allodynia, more specifically treatment of opioid-induced pain, such as opioid-induced chronic migraine, opioid-induced hyperalgesia (OIH), and opioid-induced allodynia (OIA), by administration of an antibody and/or antigen-binding fragment thereof having binding specificity for PACAP. The antibody and/or antigen-binding fragment thereof may comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. The antibody and/or antigen-binding fragment thereof described herein binds to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody.
Methods for rapid treatment of chronic migraine are provided. Exemplary methods provide relief from migraine within 24 hours of administration. Also provided are methods for acute treatment of migraine. Exemplary methods comprise administration of an anti-CGRP antagonist antibody to a patient in need thereof.
Methods for immediate relief of migraine or headache are provided comprising the administration of an anti-CGRP antagonist antibody to a patient in need thereof.
The present invention relates to methods for isolating a product and/or reducing impurities such as Host Cell Proteins (HCP) from a load fluid comprising the product and one or more impurities by passing the load fluid through a medium, followed by at least one wash solution comprising arginine or an arginine derivative at a concentration above about 525mM and a pH above 8, and collecting the product using an elution solution.
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
29.
SOLID FORMS OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID
The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below.
The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below.
The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below.
The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.
The present invention relates to a pharmaceutical composition comprising zuclopenthixol, or a pharmaceutically acceptable salt thereof, and a cyclodextrin, wherein the composition exhibits an increased chemical stability of zuclopenthixol. The pharmaceutical composition finds particular application in the treatment of CNS disorder, such as in the treatment of schizophrenia, psychosis or mania.
05 - Pharmaceutical, veterinary and sanitary products
38 - Telecommunications services
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and medicinal preparations and substances; pharmaceutical preparations and substances for the prevention and treatment of disorders and diseases in, generated by or acting on the central nervous system; pharmaceutical preparations and substances, acting on the central nervous system; central nerve system stimulants; pharmaceutical preparations and substances for the prevention and treatment of psychiatric and neurological disorders and diseases; pharmaceutical preparations and substances for the prevention and treatment of dementia, Alzheimer's disease and disorder, dizziness, attack, stroke, depression, cognitive impairment, cognitive disorders and diseases, mood swings, psychosis, anxiety, apathy, epilepsy; pharmaceutical preparations and substances for the prevention and treatment of Lennox-Gastaut syndrome (LGS), sclerosis, porphyria, Huntington's disease and disorder, insomnia, Parkinsons disease and disorder, falls, movement disorders and movement disorders, tremor, schizophrenia, bipolar disorder and suffering, mania, ADHD, PTSD, agitation, aggression, autism, melancholy, OCD, Tourettes syndrome, progressive supranuclear palsy (PSP), restlessness, akathisia, fatigue, drowsiness, nausea, migraine, pain, alcoholism and addiction; compositions, drugs, reagents and agents for diagnostic and medical purposes Arranging and conducting an online forum in the field of pharmaceuticals, disease awareness and treatments; providing online chat rooms and electronic bulletin boards for transmission of messages among users in the field of pharmaceuticals, disease awareness and treatments Downloadable electronic publications, namely, books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, journals, teaching and educational material in the field of pharmaceutical research and development, disease awareness, medical clinical studies, pharmaceutical tests and trials, diagnostic medicine, medicine, pharmaceuticals, disorders, diseases, clinical or medical treatment and prevention; software for medical and pharmaceutical information, education and sales activities; software for analyzing medical and pharmaceutical information and disease awareness; software, namely, application software for mobile devices for analyzing medical and pharmaceutical information; apparatus and instruments for analyzing medical and pharmaceutical information in the field of research and development, science, clinical studies, medical clinical tests and trials, diagnostic, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; electronic downloadable publications, namely, magazines, journals, teaching and educational materials in the field of pharmaceutical research and development, science, medical clinical studies, pharmaceutical tests and trials, diagnostic medicine related to clinical or medical treatment and prevention; application software for mobile devices for the assessment of cognitive functions; downloadable software for assessment of cognitive functions; software for use in diagnosing, managing, monitoring, assessing, controlling and examining psychiatric and neurological disorders and diseases, dementia, Alzheimer's disorder and disease, dizziness, seizures, stroke, depression, cognitive impairment, cognitive disorders and diseases, mood disorders, psychosis, anxiety, apathy, epilepsy, Lennox-Gastaut syndrome (LGS), sclerosis, porphyria, Huntington's disorder and disease, insomnia, Parkinson's disorder and disease, falls, movement disorders and diseases, tremor, schizophrenia, bipolar disorder and disease, mania, ADHD, PTSD, agitation, aggression, autism, melancholy, OCD, Tourette's syndrome, progressive supranuclear palsy (PSP), restlessness, akathisia, fatigue, somnolence, nausea, migraine, pain, alcoholism and dependency Printed publications, including books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, records, educational and training materials for research and development, science, clinical studies, tests and trials, diagnostics, medicine, drugs, disorders, diseases, treatment and prevention Educational services, namely, conducting seminars in the field of pharmaceuticals and disease awareness; providing of training in the field of pharmaceuticals and disease awareness; arranging and conducting seminars, conferences, symposiums, training workshops and courses in the field of pharmaceuticals and disease awareness; educational training services in the fields of pharmaceutical research and development, medical clinical studies, pharmaceutical tests and trials and diagnostic medicine related to the treatment and prevention of diseases and disorders; providing the aforementioned services electronically, on-line, via cable or Internet or other electronic media; arranging and conducting expert forums, namely, on-line training programs in the field of pharmaceuticals; providing on-line, non-downloadable publications, namely, books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, journals, teaching and educational material in the field of pharmaceutical research and development, science, medical clinical studies in the field of pharmaceutical tests and trials, diagnostic medicine, pharmaceuticals, disorders, disease awareness, treatment and prevention related to the assessment of cognitive functions; providing educational assessment services in the field of cognitive functions through on-line non-downloadable screening tools Pharmaceutical research and development; scientific and technological services, namely, scientific testing and research related to medical disorders, medical diseases and medical prevention; scientific and technological services, namely, scientific testing and research related to the central nervous system and central nervous system related disorders, pharmaceuticals and disease awareness; medical and clinical research, namely, pharmaceutical clinical research and conducting clinical trials for others in the field of pharmaceuticals; diagnostic research and tests in the field of pharmaceutical research
Described herein is the manufacture of MAGL inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate including salts thereof.
C07D 295/02 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
C07D 295/023 - PreparationSeparationStabilisationUse of additives
05 - Pharmaceutical, veterinary and sanitary products
38 - Telecommunications services
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and medicinal preparations and substances; pharmaceutical preparations and substances for the prevention and treatment of disorders and diseases in, generated by or acting on the central nervous system; pharmaceutical preparations and substances, acting on the central nervous system; central nerve system stimulants; pharmaceutical preparations and substances for the prevention and treatment of psychiatric and neurological disorders and diseases; pharmaceutical preparations and substances for the prevention and treatment of dementia, Alzheimer's disease and disorder, dizziness, attack, stroke, depression, cognitive impairment, cognitive disorders and diseases, mood swings, psychosis, anxiety, apathy, epilepsy; pharmaceutical preparations and substances for the prevention and treatment of Lennox-Gastaut syndrome (LGS), sclerosis, porphyria, Huntington's disease and disorder, insomnia, Parkinsons disease and disorder, falls, movement disorders and movement disorders, tremor, schizophrenia, bipolar disorder and suffering, mania, ADHD, PTSD, agitation, aggression, autism, melancholy, OCD, Tourettes syndrome, progressive supranuclear palsy (PSP), restlessness, akathisia, fatigue, drowsiness, nausea, migraine, pain, alcoholism and addiction; compositions, drugs, reagents and agents for diagnostic and medical purposes Arranging and conducting an online forum in the field of pharmaceuticals, disease awareness and treatments; providing online chat rooms and electronic bulletin boards for transmission of messages among users in the field of pharmaceuticals, disease awareness and treatments Downloadable electronic publications, namely, books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, journals, teaching and educational material in the field of pharmaceutical research and development, disease awareness, medical clinical studies, pharmaceutical tests and trials, diagnostic medicine, medicine, pharmaceuticals, disorders, diseases, clinical or medical treatment and prevention; software for medical and pharmaceutical information, education and sales activities; software for analyzing medical and pharmaceutical information and disease awareness; software, namely, application software for mobile devices for analyzing medical and pharmaceutical information; apparatus and instruments for analyzing medical and pharmaceutical information in the field of research and development, science, clinical studies, medical clinical tests and trials, diagnostic, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; electronic downloadable publications, namely, magazines, journals, teaching and educational materials in the field of pharmaceutical research and development, science, medical clinical studies, pharmaceutical tests and trials, diagnostic medicine related to clinical or medical treatment and prevention; application software for mobile devices for the assessment of cognitive functions; downloadable software for assessment of cognitive functions; software for use in diagnosing, managing, monitoring, assessing, controlling and examining psychiatric and neurological disorders and diseases, dementia, Alzheimer's disorder and disease, dizziness, seizures, stroke, depression, cognitive impairment, cognitive disorders and diseases, mood disorders, psychosis, anxiety, apathy, epilepsy, Lennox-Gastaut syndrome (LGS), sclerosis, porphyria, Huntington's disorder and disease, insomnia, Parkinson's disorder and disease, falls, movement disorders and diseases, tremor, schizophrenia, bipolar disorder and disease, mania, ADHD, PTSD, agitation, aggression, autism, melancholy, OCD, Tourette's syndrome, progressive supranuclear palsy (PSP), restlessness, akathisia, fatigue, somnolence, nausea, migraine, pain, alcoholism and dependency Printed publications, including books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, records, educational and training materials for research and development, science, clinical studies, tests and trials, diagnostics, medicine, drugs, disorders, diseases, treatment and prevention Educational services, namely, conducting seminars in the field of pharmaceuticals and disease awareness; providing of training in the field of pharmaceuticals and disease awareness; arranging and conducting seminars, conferences, symposiums, training workshops and courses in the field of pharmaceuticals and disease awareness; educational training services in the fields of pharmaceutical research and development, medical clinical studies, pharmaceutical tests and trials and diagnostic medicine related to the treatment and prevention of diseases and disorders; providing the aforementioned services electronically, on-line, via cable or Internet or other electronic media; arranging and conducting expert forums, namely, on-line training programs in the field of pharmaceuticals; providing on-line, non-downloadable publications, namely, books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, journals, teaching and educational material in the field of pharmaceutical research and development, science, medical clinical studies in the field of pharmaceutical tests and trials, diagnostic medicine, pharmaceuticals, disorders, disease awareness, treatment and prevention related to the assessment of cognitive functions; providing educational assessment services in the field of cognitive functions through on-line non-downloadable screening tools Pharmaceutical research and development; scientific and technological services, namely, scientific testing and research related to medical disorders, medical diseases and medical prevention; scientific and technological services, namely, scientific testing and research related to the central nervous system and central nervous system related disorders, pharmaceuticals and disease awareness; medical and clinical research, namely, pharmaceutical clinical research and conducting clinical trials for others in the field of pharmaceuticals; diagnostic research and tests in the field of pharmaceutical research
05 - Pharmaceutical, veterinary and sanitary products
38 - Telecommunications services
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and medicinal preparations and substances; pharmaceutical preparations and substances for the prevention and treatment of disorders and diseases in, generated by or acting on the central nervous system; pharmaceutical preparations and substances, acting on the central nervous system; central nerve system stimulants; pharmaceutical preparations and substances for the prevention and treatment of psychiatric and neurological disorders and diseases; pharmaceutical preparations and substances for the prevention and treatment of dementia, Alzheimer's disease and disorder, dizziness, attack, stroke, depression, cognitive impairment, cognitive disorders and diseases, mood swings, psychosis, anxiety, apathy, epilepsy; pharmaceutical preparations and substances for the prevention and treatment of Lennox-Gastaut syndrome (LGS), sclerosis, porphyria, Huntington's disease and disorder, insomnia, Parkinsons disease and disorder, falls, movement disorders and movement disorders, tremor, schizophrenia, bipolar disorder and suffering, mania, ADHD, PTSD, agitation, aggression, autism, melancholy, OCD, Tourettes syndrome, progressive supranuclear palsy (PSP), restlessness, akathisia, fatigue, drowsiness, nausea, migraine, pain, alcoholism and addiction; compositions, drugs, reagents and agents for diagnostic and medical purposes Arranging and conducting an online forum in the field of pharmaceuticals, disease awareness and treatments; providing online chat rooms and electronic bulletin boards for transmission of messages among users in the field of pharmaceuticals, disease awareness and treatments Downloadable electronic publications, namely, books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, journals, teaching and educational material in the field of pharmaceutical research and development, disease awareness, medical clinical studies, pharmaceutical tests and trials, diagnostic medicine, medicine, pharmaceuticals, disorders, diseases, clinical or medical treatment and prevention; software for medical and pharmaceutical information, education and sales activities; software for analyzing medical and pharmaceutical information and disease awareness; software, namely, application software for mobile devices for analyzing medical and pharmaceutical information; apparatus and instruments for analyzing medical and pharmaceutical information in the field of research and development, science, clinical studies, medical clinical tests and trials, diagnostic, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; electronic downloadable publications, namely, magazines, journals, teaching and educational materials in the field of pharmaceutical research and development, science, medical clinical studies, pharmaceutical tests and trials, diagnostic medicine related to clinical or medical treatment and prevention; application software for mobile devices for the assessment of cognitive functions; downloadable software for assessment of cognitive functions; software for use in diagnosing, managing, monitoring, assessing, controlling and examining psychiatric and neurological disorders and diseases, dementia, Alzheimer's disorder and disease, dizziness, seizures, stroke, depression, cognitive impairment, cognitive disorders and diseases, mood disorders, psychosis, anxiety, apathy, epilepsy, Lennox-Gastaut syndrome (LGS), sclerosis, porphyria, Huntington's disorder and disease, insomnia, Parkinson's disorder and disease, falls, movement disorders and diseases, tremor, schizophrenia, bipolar disorder and disease, mania, ADHD, PTSD, agitation, aggression, autism, melancholy, OCD, Tourette's syndrome, progressive supranuclear palsy (PSP), restlessness, akathisia, fatigue, somnolence, nausea, migraine, pain, alcoholism and dependency Printed publications, including books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, records, educational and training materials for research and development, science, clinical studies, tests and trials, diagnostics, medicine, drugs, disorders, diseases, treatment and prevention Educational services, namely, conducting seminars in the field of pharmaceuticals and disease awareness; providing of training in the field of pharmaceuticals and disease awareness; arranging and conducting seminars, conferences, symposiums, training workshops and courses in the field of pharmaceuticals and disease awareness; educational training services in the fields of pharmaceutical research and development, medical clinical studies, pharmaceutical tests and trials and diagnostic medicine related to the treatment and prevention of diseases and disorders; providing the aforementioned services electronically, on-line, via cable or Internet or other electronic media; arranging and conducting expert forums, namely, on-line training programs in the field of pharmaceuticals; providing on-line, non-downloadable publications, namely, books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, journals, teaching and educational material in the field of pharmaceutical research and development, science, medical clinical studies in the field of pharmaceutical tests and trials, diagnostic medicine, pharmaceuticals, disorders, disease awareness, treatment and prevention related to the assessment of cognitive functions; providing educational assessment services in the field of cognitive functions through on-line non-downloadable screening tools Pharmaceutical research and development; scientific and technological services, namely, scientific testing and research related to medical disorders, medical diseases and medical prevention; scientific and technological services, namely, scientific testing and research related to the central nervous system and central nervous system related disorders, pharmaceuticals and disease awareness; medical and clinical research, namely, pharmaceutical clinical research and conducting clinical trials for others in the field of pharmaceuticals; diagnostic research and tests in the field of pharmaceutical research
35.
CATECHOLAMINE PRODRUGS FOR USE IN THE TREATMENT OF PARKINSON’S DISEASE
The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.
The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.
Accordingly, the present invention relates to compounds of formula (Id)
The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.
Accordingly, the present invention relates to compounds of formula (Id)
The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.
Accordingly, the present invention relates to compounds of formula (Id)
wherein
R1 is H and R2 is selected from one of the substituents (i) and (ii) below; or
R1 is selected from one of the substituents (i) and (ii) below and R2 is H; or
R1 and R2 are both represented by substituent (i) below; or
R1 and R2 are both represented by substituent (ii) below; or
R1 is substituent (i) and R2 is substituent (ii); or
R1 is substituent (ii) and R2 is substituent (i);
The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.
Accordingly, the present invention relates to compounds of formula (Id)
wherein
R1 is H and R2 is selected from one of the substituents (i) and (ii) below; or
R1 is selected from one of the substituents (i) and (ii) below and R2 is H; or
R1 and R2 are both represented by substituent (i) below; or
R1 and R2 are both represented by substituent (ii) below; or
R1 is substituent (i) and R2 is substituent (ii); or
R1 is substituent (ii) and R2 is substituent (i);
The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.
Accordingly, the present invention relates to compounds of formula (Id)
wherein
R1 is H and R2 is selected from one of the substituents (i) and (ii) below; or
R1 is selected from one of the substituents (i) and (ii) below and R2 is H; or
R1 and R2 are both represented by substituent (i) below; or
R1 and R2 are both represented by substituent (ii) below; or
R1 is substituent (i) and R2 is substituent (ii); or
R1 is substituent (ii) and R2 is substituent (i);
wherein * indicates the attachment point; and
wherein the carbon atom at the attachment point on substituent (i) is in the S-configuration; or a pharmaceutically acceptable salt thereof.
A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
A61P 25/00 - Drugs for disorders of the nervous system
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
The present invention is directed to compounds of formula IIa
These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds.
C07D 498/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
37.
TREATMENT OF MOST BOTHERSOME SYMPTOM (MBS) ASSOCIATED WITH MIGRAINE USING ANTI-CGRP ANTIBODIES
Methods for treatment of most bothersome symptom (MBS) associated with migraine are provided. Exemplary methods provide improvement in MBS associated with migraine within 1 month of administration og anti-CGRP antibodies of the invention. Also provided are methods for improvement of patient impression of change (PGIC) associated with migraine. Exemplary methods comprise administration of an anti-CGRP antagonistic antibody to a patient in need thereof.
The present invention is directed to compounds of formula IIa. These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds.
C07D 498/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
A61P 25/00 - Drugs for disorders of the nervous system
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
39.
Therapeutic Uses of Compounds Having Combined Sert, 5-HT3 and 5-HT1a Activity
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
40.
ACUTE TREATMENT AND RAPID TREATMENT OF HEADACHE USING ANTI-CGRP ANTIBODIES
Methods for rapid treatment of chronic migraine are provided. Exemplary methods provide relief from migraine within 24 hours of administration. Also provided are methods for acute treatment of migraine. Exemplary methods comprise administration of an anti-CGRP antagonist antibody to a patient in need thereof.
Methods for immediate relief of migraine or headache are provided comprising the administration of an anti-CGRP antagonist antibody to a patient in need thereof.
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Electronic publications (downloadable), including books,
reports, brochures, booklets, magazines, including leaflets,
magazines, journals, teaching and training material in
research and development, science, clinical tests,
diagnostics, medicine, pharmaceuticals, disorders, diseases,
treatment and prevention; computer software, recorded,
including software for medical and pharmaceutical
information, training and sales activities; software for
websites, intranets and the Internet; downloadable software
in the form of downloadable virtual goods authenticated by
NFTs (non-fungible tokens), namely virtual pharmaceutical
preparations and substances, including for use in online
environments, virtual environments, augmented virtual
reality environments and metaverses; downloadable software
for use in digital advice; downloadable software for use in
digital advice via apps; downloadable digital files
authenticated by NFTs (non-fungible tokens); downloadable
software for preparing, managing, storing, making available,
sending, receiving, exchanging, validating and selling
virtual pharmaceutical preparations and substances. Wholesale and retail trade in pharmaceuticals; advertising
agency services in the field of research and development,
science, clinical tests, diagnostics, medicine,
pharmaceuticals, disorders, diseases, treatment and
prevention; provision of the aforementioned services online,
via cable or Internet or other electronic media; online
retailing of digital files as well as virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens); providing an online marketplace for
buyers and sellers of digital files and virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Electronic publications (downloadable), including books,
reports, brochures, booklets, magazines, including leaflets,
magazines, journals, teaching and training material in
research and development, science, clinical tests,
diagnostics, medicine, pharmaceuticals, disorders, diseases,
treatment and prevention; computer software, recorded,
including software for medical and pharmaceutical
information, training and sales activities; software for
websites, intranets and the Internet; downloadable software
in the form of downloadable virtual goods authenticated by
NFTs (non-fungible tokens), namely virtual pharmaceutical
preparations and substances, including for use in online
environments, virtual environments, augmented virtual
reality environments and metaverses; downloadable software
for use in digital advice; downloadable software for use in
digital advice via apps; downloadable digital files
authenticated by NFTs (non-fungible tokens); downloadable
software for preparing, managing, storing, making available,
sending, receiving, exchanging, validating and selling
virtual pharmaceutical preparations and substances. Wholesale and retail trade in pharmaceuticals; advertising
agency services in the field of research and development,
science, clinical tests, diagnostics, medicine,
pharmaceuticals, disorders, diseases, treatment and
prevention; provision of the aforementioned services online,
via cable or internet or other electronic media; online
retailing of digital files as well as virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens); providing an online marketplace for
buyers and sellers of digital files and virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Electronic publications (downloadable), including books,
reports, brochures, booklets, magazines, including leaflets,
magazines, journals, teaching and training material in
research and development, science, clinical tests,
diagnostics, medicine, pharmaceuticals, disorders, diseases,
treatment and prevention; computer software, recorded,
including software for medical and pharmaceutical
information, training and sales activities; software for
websites, intranets and the Internet; downloadable software
in the form of downloadable virtual goods authenticated by
NFTs (non-fungible tokens), namely virtual pharmaceutical
preparations and substances, including for use in online
environments, virtual environments, augmented virtual
reality environments and metaverses; downloadable software
for use in digital advice; downloadable software for use in
digital advice via apps; downloadable digital files
authenticated by NFTs (non-fungible tokens); downloadable
software for preparing, managing, storing, making available,
sending, receiving, exchanging, validating and selling
virtual pharmaceutical preparations and substances. Wholesale and retail trade in pharmaceuticals; advertising
agency services in the field of research and development,
science, clinical tests, diagnostics, medicine,
pharmaceuticals, disorders, diseases, treatment and
prevention; provision of the aforementioned services online,
via cable or Internet or other electronic media; online
retailing of digital files as well as virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens); providing an online marketplace for
buyers and sellers of digital files and virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Electronic publications (downloadable), including books,
reports, brochures, booklets, magazines, including leaflets,
magazines, journals, teaching and training material in
research and development, science, clinical tests,
diagnostics medicine, pharmaceuticals, disorders, diseases,
treatment and prevention; computer software recorded
including software for medical and pharmaceutical
information, training and sales activities; software for
websites, intranets and the Internet; downloadable software
in the form of downloadable virtual goods authenticated by
NFTs (non-fungible tokens), namely virtual pharmaceutical
preparations and substances, including for use in online
environments virtual environments, augmented virtual reality
environments and metaverses; downloadable software for use
in digital advice; downloadable software for use in digital
advice via apps; downloadable digital files authenticated by
NFTs (non-fungible tokens), downloadable software for
preparing, managing, storing, making available, sending,
receiving, exchanging, validating and selling virtual
pharmaceutical preparations and substances. Wholesale and retail trade in pharmaceuticals; advertising
agency services in the field of research and development,
science, clinical tests, diagnostics medicine,
pharmaceuticals, disorders, diseases, treatment and
prevention; provision of the aforementioned services online,
via cable or Internet or other electronic media; online
retailing of digital files as well as virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens); providing an online marketplace for
buyers and sellers of digital files and virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Electronic publications (downloadable), including books,
reports, brochures, booklets, magazines, including leaflets,
magazines, journals, teaching and training material in
research and development, science, clinical tests,
diagnostics, medicine, pharmaceuticals, disorders, diseases,
treatment and prevention; computer software, recorded,
including software for medical and pharmaceutical
information, training and sales activities; software for
websites, intranets and the Internet; downloadable software
in the form of downloadable virtual goods authenticated by
NFTs (non-fungible tokens), namely virtual pharmaceutical
preparations and substances, including for use in online
environments, virtual environments, augmented virtual
reality environments and metaverses; downloadable software
for use in digital advice; downloadable software for use in
digital advice via apps; downloadable digital files
authenticated by NFTs (non-fungible tokens); downloadable
software for preparing, managing, storing, making available,
sending, receiving, exchanging, validating and selling
virtual pharmaceutical preparations and substances. Wholesale and retail trade in pharmaceuticals; advertising
agency services in the field of research and development,
science, clinical tests, diagnostics, medicine,
pharmaceuticals, disorders, diseases, treatment and
prevention; provision of the aforementioned services online,
via cable or Internet or other electronic media; online
retailing of digital files as well as virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens); providing an online marketplace for
buyers and sellers of digital files and virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Electronic publications (downloadable), including books,
reports, brochures, booklets, magazines, including leaflets,
magazines, journals, teaching and training material in
research and development, science, clinical tests,
diagnostics, medicine, pharmaceuticals, disorders, diseases,
treatment and prevention; computer software, recorded,
including software for medical and pharmaceutical
information, training and sales activities; software for
websites, intranets and the Internet; downloadable software
in the form of downloadable virtual goods authenticated by
NFTs (non-fungible tokens), namely virtual pharmaceutical
preparations and substances, including for use in online
environments, virtual environments, augmented virtual
reality environments and metaverses; downloadable software
for use in digital advice; downloadable software for use in
digital advice via apps; downloadable digital files
authenticated by NFTs (non-fungible tokens); downloadable
software for preparing, managing, storing, making available,
sending, receiving, exchanging, validating and selling
virtual pharmaceutical preparations and substances. Wholesale and retail trade in pharmaceuticals; advertising
agency services in the field of research and development,
science, clinical tests, diagnostics, medicine,
pharmaceuticals, disorders, diseases, treatment and
prevention; provision of the aforementioned services online,
via cable or Internet or other electronic media; online
retailing of digital files as well as virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens); providing an online marketplace for
buyers and sellers of digital files and virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Electronic publications (downloadable), including books,
reports, brochures, booklets, magazines, including leaflets,
magazines, journals, teaching and training material in
research and development, science, clinical tests,
diagnostics, medicine, pharmaceuticals, disorders, diseases,
treatment and prevention; computer software, recorded,
including software for medical and pharmaceutical
information, training and sales activities; software for
websites, intranets and the Internet; downloadable software
in the form of downloadable virtual goods authenticated by
NFTs (non-fungible tokens), namely virtual pharmaceutical
preparations and substances, including for use in online
environments, virtual environments, augmented virtual
reality environments and metaverses; downloadable software
for use in digital advice; downloadable software for use in
digital advice via apps; downloadable digital files
authenticated by NFTs (non-fungible tokens); downloadable
software for preparing, managing, storing, making available,
sending, receiving, exchanging, validating and selling
virtual pharmaceutical preparations and substances. Wholesale and retail trade in pharmaceuticals; advertising
agency services in the field of research and development,
science, clinical tests, diagnostics, medicine,
pharmaceuticals, disorders, diseases, treatment and
prevention; provision of the aforementioned services online,
via cable or Internet or other electronic media; online
retailing of digital files as well as virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens); providing an online marketplace for
buyers and sellers of digital files and virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Electronic publications (downloadable), including books,
reports, brochures, booklets, magazines, including leaflets,
magazines, journals, teaching and training material in
research and development, science, clinical tests,
diagnostics, medicine, pharmaceuticals, disorders, diseases,
treatment and prevention; computer software, recorded,
including software for medical and pharmaceutical
information, training and sales activities; software for
websites, intranets and the Internet; downloadable software
in the form of downloadable virtual goods authenticated by
NFTs (non-fungible tokens), namely virtual pharmaceutical
preparations and substances, including for use in online
environments, virtual environments, augmented virtual
reality environments and metaverses; downloadable software
for use in digital advice; downloadable software for use in
digital advice via apps; downloadable digital files
authenticated by NFTs (non-fungible tokens); downloadable
software for preparing, managing, storing, making available,
sending, receiving, exchanging, validating and selling
virtual pharmaceutical preparations and substances. Wholesale and retail trade in pharmaceuticals; advertising
agency services in the field of research and development,
science, clinical tests, diagnostics, medicine,
pharmaceuticals, disorders, diseases, treatment and
prevention; provision of the aforementioned services online,
via cable or Internet or other electronic media; online
retailing of digital files as well as virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens); providing an online marketplace for
buyers and sellers of digital files and virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Electronic publications (downloadable), including books,
reports, brochures, booklets, magazines, including leaflets,
magazines, journals, teaching and training material in
research and development, science, clinical tests,
diagnostics, medicine, pharmaceuticals, disorders, diseases,
treatment and prevention; computer software, recorded,
including software for medical and pharmaceutical
information, training and sales activities; software for
websites, intranets and the Internet; downloadable software
in the form of downloadable virtual goods authenticated by
NFTs (non-fungible tokens), namely virtual pharmaceutical
preparations and substances, including for use in online
environments, virtual environments, augmented virtual
reality environments and metaverses; downloadable software
for use in digital advice; downloadable software for use in
digital advice via apps; downloadable digital files
authenticated by NFTs (non-fungible tokens); downloadable
software for preparing, managing, storing, making available,
sending, receiving, exchanging, validating and selling
virtual pharmaceutical preparations and substances. Wholesale and retail trade in pharmaceuticals; advertising
agency services in the field of research and development,
science, clinical tests, diagnostics, medicine,
pharmaceuticals, disorders, diseases, treatment and
prevention; provision of the aforementioned services online,
via cable or Internet or other electronic media; online
retailing of digital files as well as virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens); providing an online marketplace for
buyers and sellers of digital files and virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Electronic publications (downloadable), including books,
reports, brochures, booklets, magazines, including leaflets,
magazines, journals, teaching and training material in the
field of research and development, science, clinical tests,
diagnostics, medicine, pharmaceuticals, disorders, diseases,
treatment and prevention; computer software, recorded,
including software for medical and pharmaceutical
information, training and sales activities; software for
websites, intranets and the Internet; downloadable software
in the form of downloadable virtual goods authenticated by
NFTs (non-fungible tokens), namely virtual pharmaceutical
preparations and substances, including for use in online
environments, virtual environments, augmented virtual
reality environments and metaverses; downloadable software
for use in digital advice; downloadable software for use in
digital advice via apps; downloadable digital files
authenticated by NFTs (non-fungible tokens); downloadable
software for preparing, managing, storing, making available,
sending, receiving, exchanging, validating and selling
virtual pharmaceutical preparations and substances. Wholesale and retail trade in pharmaceuticals; advertising
agency services in the field of research and development,
science, clinical tests, diagnostics, medicine,
pharmaceuticals, disorders, diseases, treatment and
prevention; provision of the aforementioned services online,
via cable or Internet or other electronic media; online
retailing of digital files as well as virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens); providing an online marketplace for
buyers and sellers of digital files and virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Scientific, surveying, photographic, cinematographic,
audio-visual and optical apparatus and instruments, and
apparatus and instruments for research, navigation,
weighing, measuring, signalling, detection, testing,
inspection, life-saving and teaching; apparatus and
instruments for conducting, switching, transforming,
accumulating, regulating or controlling the distribution and
use of electricity; apparatus and instruments for recording,
transmission and reproduction of sound; electronic
publications (downloadable), including books, reports,
brochures, booklets, magazines, including leaflets,
magazines, journals, teaching and training material in
research and development, science, clinical tests,
diagnostics, medicines, pharmaceuticals, disorders,
diseases, treatment and prevention; computer software,
recorded, including software for medical and pharmaceutical
information, training and sales activities; software for
websites, intranets and the Internet; downloadable software
in the form of downloadable virtual goods authenticated by
NFTs (non-fungible tokens), namely virtual pharmaceutical
preparations and substances, including for use in online
environments, virtual environments, augmented virtual
reality environments and metaverses; downloadable software
for use in digital advice; downloadable software for use in
digital advice via apps; downloadable digital files
authenticated by NFTs (non-fungible tokens); downloadable
software for preparing, managing, storing, making available,
sending, receiving, exchanging, validating and selling
virtual pharmaceutical preparations and substances. Wholesale and retail trade in pharmaceuticals; advertising
agency services in the field of research and development,
science, clinical tests, diagnostics, medicine,
pharmaceuticals, disorders, diseases, treatment and
prevention; provision of the aforementioned services online,
via cable or Internet or other electronic media; online
retailing of digital files as well as virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens); providing an online marketplace for
buyers and sellers of digital files and virtual goods in the
form of pharmaceutical preparations and substances,
including goods and files authenticated by NFTs
(non-fungible tokens).
53.
Compositions and methods for treating synucleinopathies
The present invention relates to stable and low viscosity liquid pharmaceutical compositions comprising antibodies binding to human alpha synuclein and to methods for use of antibodies binding to human alpha synuclein for treating synucleinopathies or prodromal synucleinopathy, incl. suitable doses and/or dosing regimens. These antibodies for use in treatment of synucleinopathies or prodromal synucleinopathy may be formulated in the stable and low viscosity liquid pharmaceutical compositions of the invention.
The present invention provides sulfamate derivative prodrugs of the dopamine agonist (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol, their use in the treatment of conditions for which treatment with a dopamine agonist is therapeutically beneficial and pharmaceutical compositions comprising compounds of the invention. Compounds according to the invention are of formula (Id), wherein R1 and R2 are each independently selected from H, and substituent (iii) below, wherein * indicates the attachment point to oxygen, wherein R3 is selected from H and COR4, and wherein R4 is selected from H and C1-C6 alkyl, with the proviso that R1 and R2 cannot both be H,15 or a pharmaceutically acceptable salt thereof.
Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
PROCESS FOR THE MANUFACTURING OF (6AR,10AR)-7-PROPYL-6,6A,7,8,9,10,10A,11-OCTAHYDRO-[1,3]DIOXOLO[4',5':5,6]BENZO[1,2-G]QUINOLINE AND (4AR,10AR)-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDRO-BENZO[G]QUINOLINE-6,7-DIOL
The present invention relates to a new process for manufacturing (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-g]quinoline with formula (Ib) below, (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol with formula (I) below and salts thereof.
The present invention relates to a new process for manufacturing (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-g]quinoline with formula (Ib) below, (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol with formula (I) below and salts thereof.
The present invention relates to a new process for manufacturing (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-g]quinoline with formula (Ib) below, (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol with formula (I) below and salts thereof.
Both compounds are for use in the treatment of neurodegenerative diseases and disorders such as Parkinson's Disease. The invention also relates to new intermediate compounds of said process.
C07D 215/06 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
C07D 317/60 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
The present invention is directed to compounds of formula I
The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.
C07D 498/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations and substances for the prevention and treatment of disorders and diseases in, generated by or acting on the central nervous system; pharmaceutical preparations and substances acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of psychiatric and neurological disorders and diseases; pharmaceutical preparations and substances for the prevention and treatment of depression, cognitive disorders, mood disorders; pharmaceuticals for treatment of cognitive disorders and diseases
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations and substances for the prevention and treatment of disorders and diseases in, generated by or acting on the central nervous system; pharmaceutical preparations and substances acting on the central nervous system; pharmaceutical preparations and substances for the prevention and treatment of psychiatric and neurological disorders and diseases; pharmaceutical preparations and substances for the prevention and treatment of depression, cognitive disorders, mood disorders; pharmaceuticals for treatment of cognitive disorders and diseases
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
(1) Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely virtual pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances. (1) Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
(1) Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely virtual pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances. (1) Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
(1) Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely virtual pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances. (1) Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
(1) Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely virtual pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances. (1) Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
(1) Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics, medicines, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely virtual pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances. (1) Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
(1) Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely virtual pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances. (1) Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
(1) Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely virtual pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances. (1) Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Downloadable electronic publications in the nature of books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, being software for medical and pharmaceutical information, training and sales activities; recorded and downloadable computer networking software for accessing websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely, image files of pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital image files of pharmaceuticals and substances authenticated by non-fungible tokens (NFTs); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances Wholesale and retail store services featuring pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, namely, goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, namely, goods and files authenticated by NFTs (non-fungible tokens)
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Downloadable electronic publications in the nature of books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, being software for medical and pharmaceutical information, training and sales activities; recorded and downloadable computer networking software for accessing websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by non-fungible tokens (NFTs), namely, image files of pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital image files of pharmaceuticals and substances authenticated by non-fungible tokens (NFTs); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances Wholesale and retail store services featuring pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, namely, goods and files authenticated by non-fungible tokens (NFTs); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, namely, goods and files authenticated by non-fungible tokens (NFTs)
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Downloadable electronic publications in the nature of books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; recorded computer software for medical and pharmaceutical information, training and sales activities; recorded and downloadable computer networking software for accessing websites, intranets and the Internet; downloadable computer software for creating and managing image files of virtual pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs), including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable computer software for creating searchable databases of information and data in the field of digital advice; downloadable software in the nature of a mobile application for creating searchable databases of information and data in the field of digital advice; downloadable digital image files of pharmaceuticals and substances authenticated by non-fungible tokens (NFTs); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling image files of virtual goods, namely, virtual pharmaceutical preparations and substances Online wholesale and retail store services featuring pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention via cable and the Internet; online retail store services featuring downloadable virtual pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens), for use in online virtual worlds; providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs)
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Downloadable electronic publications in the nature of books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; recorded computer software for medical and pharmaceutical information, training and sales activities; recorded and downloadable computer networking software for accessing websites, intranets and the Internet; downloadable computer software for creating and managing image files of virtual pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs), including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable computer software for creating searchable databases of information and data in the field of digital advice; downloadable software in the nature of a mobile application for creating searchable databases of information and data in the field of digital advice; downloadable digital image files of pharmaceuticals and substances authenticated by non-fungible tokens (NFTs); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling image files of virtual goods, namely, virtual pharmaceutical preparations and substances Online wholesale and retail store services featuring pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention via cable and the Internet; online retail store services featuring downloadable virtual pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens), for use in online virtual worlds; providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, authenticated by non-fungible tokens (NFTs)
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Downloadable electronic publications in the nature of books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; recorded and downloadable computer software for medical and pharmaceutical information, training and sales activities; recorded and downloadable computer networking software for accessing websites, intranets and the Internet; downloadable computer software for creating and managing image files of virtual pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs), including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable computer software for creating searchable databases of information and data in the field of digital advice; downloadable software in the nature of a mobile application for creating searchable databases of information and data in the field of digital advice; downloadable digital image files of pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling image files of virtual goods, namely, virtual pharmaceutical preparations and substances Online wholesale and retail store services featuring pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention via cable and the Internet; online retail store services featuring downloadable virtual pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens), for use in online virtual worlds; providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs)
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
(1) Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely virtual pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances. (1) Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
(1) Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely virtual pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances. (1) Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
(1) Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software recorded including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely virtual pharmaceutical preparations and substances, including for use in online environments virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens), downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances. (1) Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
(1) Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software, recorded, including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely virtual pharmaceutical preparations and substances, including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances. (1) Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens).
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Downloadable electronic publications in the nature of books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; recorded computer software for medical and pharmaceutical information, training and sales activities; recorded and downloadable computer networking software for accessing websites, intranets and the Internet; downloadable computer software for creating and managing image files of virtual pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs), including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable computer software for creating searchable databases of information and data in the field of digital advice; downloadable software in the nature of a mobile application for creating searchable databases of information and data in the field of digital advice; downloadable digital image files of pharmaceuticals and substances authenticated by non-fungible tokens (NFTs); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling image files of virtual goods, namely, virtual pharmaceutical preparations and substances Online wholesale and retail store services featuring pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention via cable and the Internet; online retail store services featuring downloadable virtual pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens), for use in online virtual worlds; providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs)
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Downloadable electronic publications in the nature of books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; recorded computer software for medical and pharmaceutical information, training and sales activities; recorded and downloadable computer networking software for accessing websites, intranets and the Internet; downloadable computer software for creating and managing image files of virtual pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs), including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable computer software for creating searchable databases of information and data in the field of digital advice; downloadable software in the nature of a mobile application for creating searchable databases of information and data in the field of digital advice; downloadable digital image files of pharmaceuticals and substances authenticated by non-fungible tokens (NFTs); downloadable computer software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling image files of virtual goods, namely, virtual pharmaceutical preparations and substances Online wholesale and retail store services featuring pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention via cable and the Internet; online retail store services featuring downloadable virtual pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens), for use in online virtual worlds; providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances authenticated by NFTs (non-fungible tokens)
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Downloadable electronic publications in the nature of books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; recorded computer software for medical and pharmaceutical information, training and sales activities; recorded and downloadable computer networking software for accessing websites, intranets and the Internet; downloadable computer software for creating and managing image files of virtual pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs), including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable computer software for creating searchable databases of information and data in the field of digital advice; downloadable software in the nature of a mobile application for creating searchable databases of information and data in the field of digital advice; downloadable digital image files of pharmaceuticals and substances authenticated by non-fungible tokens (NFTs); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling image files of virtual goods, namely, virtual pharmaceutical preparations and substances Online wholesale and retail store services featuring pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention via cable and the Internet; online retail store services featuring downloadable virtual pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens), for use in online virtual worlds; providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs)
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Downloadable electronic publications in the nature of books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; recorded computer software for medical and pharmaceutical information, training and sales activities; recorded and downloadable computer networking software for accessing websites, intranets and the Internet; downloadable computer software for creating and managing image files of virtual pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs), including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable computer software for creating searchable databases of information and data in the field of digital advice; downloadable software in the nature of a mobile application for creating searchable databases of information and data in the field of digital advice; downloadable digital image files of pharmaceuticals and substances authenticated by non-fungible tokens (NFTs); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling image files of virtual goods, namely, virtual pharmaceutical preparations and substances Online wholesale and retail store services featuring pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention via cable and the Internet; online retail store services featuring downloadable virtual pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens), for use in online virtual worlds; providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs)
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Downloadable electronic publications in the nature of books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention; recorded computer software for medical and pharmaceutical information, training and sales activities; recorded and downloadable computer networking software for accessing websites, intranets and the Internet; downloadable computer software for creating and managing image files of virtual pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs), including for use in online environments, virtual environments, augmented virtual reality environments and metaverses; downloadable computer software for creating searchable databases of information and data in the field of digital advice; downloadable software in the nature of a mobile application for creating searchable databases of information and data in the field of digital advice; downloadable digital image files of pharmaceuticals and substances authenticated by non-fungible tokens (NFTs); downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling image files of virtual goods, namely, virtual pharmaceutical preparations and substances Online wholesale and retail store services featuring pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics, medicine, pharmaceuticals, disorders, diseases, treatment and prevention via cable and the Internet; online retail store services featuring downloadable virtual pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens), for use in online virtual worlds; providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances authenticated by non-fungible tokens (NFTs)
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Electronic publications (downloadable), including books, reports, brochures, booklets, magazines, including leaflets, magazines, journals, teaching and training material in research and development, science, clinical tests, diagnostics medicine, pharmaceuticals, disorders, diseases, treatment and prevention; computer software recorded including software for medical and pharmaceutical information, training and sales activities; software for websites, intranets and the Internet; downloadable software in the form of downloadable virtual goods authenticated by NFTs (non-fungible tokens), namely, virtual pharmaceutical preparations and substances, including for use in online environments virtual environments, augmented virtual reality environments and metaverses; downloadable software for use in digital advice; downloadable software for use in digital advice via apps; downloadable digital files authenticated by NFTs (non-fungible tokens), downloadable software for preparing, managing, storing, making available, sending, receiving, exchanging, validating and selling virtual pharmaceutical preparations and substances Wholesale and retail trade in pharmaceuticals; advertising agency services in the field of research and development, science, clinical tests, diagnostics medicine, pharmaceuticals, disorders, diseases, treatment and prevention; provision of the aforementioned services online, via cable or Internet or other electronic media; online retailing of digital files as well as virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens); providing an online marketplace for buyers and sellers of digital files and virtual goods in the form of pharmaceutical preparations and substances, including goods and files authenticated by NFTs (non-fungible tokens)
Described herein is new crystalline forms of the MAGL inhibitor 1,1,1,3,3,3-Hexafluoropropan-2-yl (S)-1-(pyridazin-3-ylcarbamoyl)-6-azaspiro[2.5]octane-6-carboxylate.
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
83.
CRYSTALLINE FORM OF 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-YL (S)-1-(PYRIDAZIN-3-YLCARBAMOYL)-6 AZASPIRO[2.5]OCTANE-6-CARBOXYLATE AS MONOACYLGLYCEROL LIPASE INHIBITOR.
Described herein is new crystalline forms of the MAGL inhibitor 1,1,1,3,3,3-Hexafluoropropan-2-yl (S)-1- (pyridazin-3-ylcarbamoyl)-6-azaspiro[2.5]octane-6-carboxylate.
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
A61P 25/00 - Drugs for disorders of the nervous system
A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Pharmaceutical and medicinal preparations and substances;
pharmaceutical preparations and substances for the
prevention and treatment of disorders and diseases in,
generated from or acting on the central nervous system;
pharmaceutical preparations and substances acting on the
central nervous system; central nervous system stimulants;
pharmaceutical preparations and substances for the
prevention and treatment of psychiatric and neurological
disorders and diseases; pharmaceutical preparations and
substances for the prevention and treatment of dementia,
Alzheimer's disease and disorder, dizziness, seizures,
stroke, depression, cognitive impairment, cognitive
disorders and diseases, mood swings, psychosis, anxiety,
apathy, epilepsy; pharmaceutical preparations and substances
for the prevention and treatment of lennox-gastaut syndrome
(LGS), sclerosis, porphyria, huntington's disease and
disorder, insomnia, parkinson's disease and disorder, falls,
movement disorders and movement disorders, tremor,
schizophrenia, bipolar disease and disorder, ADHD, migraine,
pain, alcoholism and addiction; preparations, substances,
reagents and agents for diagnostic and medical purposes. Downloadable software in the form of downloadable virtual
goods authenticated by NFTs (non-fungible tokens), namely
virtual pharmaceutical preparations and substances,
including for use in online environments, virtual
environments, augmented virtual reality environments and
metaverses; downloadable software for use in digital
consulting; downloadable digital files authenticated by NFTs
(non-fungible tokens); downloadable software for preparing,
managing, storing, making available, sending, receiving,
exchanging, validating and selling virtual pharmaceutical
preparations and substances. Online retail store services featuring digital files as well
as virtual goods in the form of pharmaceutical preparations
and substances, in the nature of downloadable image files
authenticated by NFTs (non-fungible tokens); provision of an
online marketplace for buyers and sellers of digital files
as well as virtual goods in the form of pharmaceutical
preparations and substances, including goods and files
authenticated by NFTs (non-fungible tokens).
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Pharmaceutical and medicinal preparations and substances;
pharmaceutical preparations and substances for the
prevention and treatment of disorders and diseases in,
generated from or acting on the central nervous system;
pharmaceutical preparations and substances acting on the
central nervous system; central nervous system stimulants;
pharmaceutical preparations and substances for the
prevention and treatment of psychiatric and neurological
disorders and diseases; pharmaceutical preparations and
substances for the prevention and treatment of dementia,
Alzheimer's disease and disorder, dizziness, seizures,
stroke, depression, cognitive impairment, cognitive
disorders and diseases, mood swings, psychosis, anxiety,
apathy, epilepsy; pharmaceutical preparations and substances
for the prevention and treatment of lennox-gastaut syndrome
(LGS), sclerosis, porphyria, huntington's disease and
disorder, insomnia, parkinson's disease and disorder, falls,
movement disorders and movement disorders, tremor,
schizophrenia, bipolar disease and disorder, ADHD, migraine,
pain, alcoholism and addiction; preparations, substances,
reagents and agents for diagnostic and medical purposes. Downloadable software in the form of downloadable virtual
goods authenticated by NFTs (non-fungible tokens), namely
virtual pharmaceutical preparations and substances,
including for use in online environments, virtual
environments, augmented virtual reality environments and
metaverses; downloadable software for use in digital
consulting; downloadable digital files authenticated by NFTs
(non-fungible tokens); downloadable software for preparing,
managing, storing, making available, sending, receiving,
exchanging, validating and selling virtual pharmaceutical
preparations and substances. Online retail store services featuring digital files as well
as virtual goods in the form of pharmaceutical preparations
and substances, in the nature of downloadable image files
authenticated by NFTs (non-fungible tokens); provision of an
online marketplace for buyers and sellers of digital files
as well as virtual goods in the form of pharmaceutical
preparations and substances, including goods and files
authenticated by NFTs (non-fungible tokens).
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
35 - Advertising and business services
Goods & Services
Pharmaceutical and medicinal preparations and substances;
pharmaceutical preparations and substances for the
prevention and treatment of disorders and diseases in,
generated from or acting on the central nervous system;
pharmaceutical preparations and substances acting on the
central nervous system; central nervous system stimulants;
pharmaceutical preparations and substances for the
prevention and treatment of psychiatric and neurological
disorders and diseases; pharmaceutical preparations and
substances for the prevention and treatment of dementia,
Alzheimer's disease and disorder, dizziness, seizures,
stroke, depression, cognitive impairment, cognitive
disorders and diseases, mood swings, psychosis, anxiety,
apathy, epilepsy; pharmaceutical preparations and substances
for the prevention and treatment of lennox-gastaut syndrome
(LGS), sclerosis, porphyria, huntington's disease and
disorder, insomnia, parkinson's disease and disorder, falls,
movement disorders and movement disorders, tremor,
schizophrenia, bipolar disease and disorder, ADHD, migraine,
pain, alcoholism and addiction; preparations, substances,
reagents and agents for diagnostic and medical purposes. Downloadable software in the form of downloadable virtual
goods authenticated by NFTs (non-fungible tokens), namely
virtual pharmaceutical preparations and substances,
including for use in online environments, virtual
environments, augmented virtual reality environments and
metaverses; downloadable software for use in digital
consulting; downloadable digital files authenticated by NFTs
(non-fungible tokens); downloadable software for preparing,
managing, storing, making available, sending, receiving,
exchanging, validating and selling virtual pharmaceutical
preparations and substances. Online retail store services featuring digital files as well
as virtual goods in the form of pharmaceutical preparations
and substances, in the nature of downloadable image files
authenticated by NFTs (non-fungible tokens); provision of an
online marketplace for buyers and sellers of digital files
as well as virtual goods in the form of pharmaceutical
preparations and substances, including goods and files
authenticated by NFTs (non-fungible tokens).
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations and substances for the prevention and treatment of disorders and diseases in, generated by or acting on the central nervous system and specifically excluding hormonal preparations, over-the-counter preparations, nutritional and dietary supplements and nutritional drink mixes Apparatus and instruments for diagnostic purposes, namely, dosage management dispensers for medicines and containing downloadable and recorded software for medical information management for use in web-based physical and psychological examination and assessment of patients at a distance and at a clinic; dosage management dispensers for guidance and control of medicines and containing downloadable and recorded software for medical information management and therapeutic use in web-based physical and psychological examination and assessment of patients at a distance and at a clinic Providing on-line educational and training services in the medical and pharmaceutical fields relating to disorders and diseases in, generated by or acting on the central nervous system via cable, internet and other electronic media, namely, providing classes, seminars and workshops in the fields of medical research and development and clinical studies related to diseases and disorders in, generated by or acting on the central nervous system; providing on-line, non-downloadable publications in the nature of books, reports, brochures, booklets, leaflets, patient information leaflets, magazines, journals, teaching and educational textbooks and manuals in the field of medical research and development and related to diseases and disorders in, generated by or acting on the central nervous system Medical and healthcare services for human beings, namely, providing on-line medical data and analyses designed to provide patients and clients customized information regarding medical dosage, diagnosis, therapeutic issues and medical management of medicines acting on the central nervous system
88.
Carbamate compounds and methods of making and using same
This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
C07C 271/10 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 271/12 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
C07D 205/04 - Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
C07D 207/09 - Radicals substituted by nitrogen atoms not forming part of a nitro radical
C07D 207/14 - Nitrogen atoms not forming part of a nitro radical
C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
C07D 215/42 - Nitrogen atoms attached in position 4
C07D 215/46 - Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 241/04 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
C07D 261/08 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 263/32 - Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 307/79 - Benzo [b] furansHydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D 317/46 - Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
C07D 317/58 - Radicals substituted by nitrogen atoms
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 401/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
C07D 403/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
C07D 407/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 413/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
The invention relates to novel monoclonal anti-alpha-synuclein antibodies. The antibodies can be used for treating a synucleinopathy such as Parkinson's disease (including idiopathic and inherited forms of Parkinson's disease), Diffuse Lewy Body Disease (DLBD), Lewy body variant of Alzheimer's disease (LBV), Combined Alzheimer's and Parkinson disease, pure autonomic failure and multiple system atrophy.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical and medical preparations and substances;
vaccines; pharmaceutical preparations and substances for the
prevention and treatment of disorders and diseases in,
generated from or acting on the central nervous system;
pharmaceutical preparations and substances acting on the
central nervous system; central nervous system stimulants;
pharmaceutical preparations and substances for the
prevention and treatment of psychiatric and neurological
disorders and diseases; pharmaceutical preparations and
substances for the prevention and treatment of Alzheimer's
disease and disorder, stroke, depression, cognitive
impairment and impaired function, mood swings, psychosis,
anxiety, epilepsy, sclerosis, porphyria, Huntington's
disease and disorder, insomnia, Parkinson's disease and
disorder, schizophrenia, bipolar illness and disorder, ADHD,
oncology, pain, alcoholism and addiction; preparations,
substances, reagents and agents for diagnostic and medical
purposes; pharmaceutical preparations for the treatment of
cognitive disorders. Surgical and medical apparatus and instruments; apparatus
and instruments for diagnostic purposes, including test
kits; integrated medical systems comprising medical devices
incorporating information management software for use in
web-based physiological, psychological and neurological
examination and assessment of patients and clients remotely
and in the clinic; medical instruments for information,
advice and handling of medicines.
Described herein are new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.
C07D 231/14 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 491/048 - Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
C07D 451/02 - Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamineCyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropaneCyclic acetals thereof
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 405/10 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
93.
PDE9 INHIBITORS WITH IMIDAZO TRIAZINONE BACKBONE AND IMIDAZO PYRAZINONE BACKBONE FOR TREATMENT OF PERIPHERAL DISEASES
The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this invention relates to the antibodies binding fragments thereof described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-ACTH antibodies and binding fragments thereof for the diagnosis, assessment, prevention and treatment of diseases and disorders associated with ACTH, such as Cushing's Disease, Cushing's Syndrome, Parkinson's disease, obesity, diabetes, sleep disorders depression, anxiety disorders, cancer, muscle atrophy, hypertension, hyperinsulinemia, cognitive dysfunction, Alzheimer's disease, galactorrhea, stress related conditions, cardiac conditions, metabolic syndrome, hyperaldosteronism, Conn's syndrome and familial hyperaldosteronism.
The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
96.
Prodrugs of 4-( (1R, 3S)-6-chloro-3-phenyl-2, 3-dihydro-1H-inden-1-yl)-1,2, 2-trimethylpiperazine and 4-( (1R, 3S)-6-chloro-3-(phenyl-D5)-2, 3-dihydro-1H-inden-1-yl)-2, 2-dimethyl-1 (methyl-D3) piperazine
b, wherein X− is a counter ion, or pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical composition comprising prodrugs, or pharmaceutically acceptable salts thereof, of the invention.
C07D 295/037 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements with quaternary ring nitrogen atoms
97.
CRYSTALLINE FORMS OF A MONOACYLGLYCEROL LIPASE INHIBITOR
Described herein is new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
The present invention is directed to compounds of formula I
The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.
C07D 498/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
99.
CRYSTALLINE FORMS OF A MONOACYLGLYCEROL LIPASE INHIBITOR
Described herein is new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
The present invention is directed to compounds of formula I. The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.
C07D 498/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
