Iron oxide nanoparticle compositions, methods of preparing the nanoparticles using high gravity controlled precipitation (HGCP), and methods of using the nanoparticles are disclosed.
SAMSUNG FINE CHEMICALS CO., LTD (Republic of Korea)
NANOMATERIALS TECHNOLOGY PTE LTD (Singapore)
Inventor
Song, Hyun A
Chang, Dong Gyu
Yang, Woo Young
Soh, Wei Kian
Shen, Zhigang
Zhang, Jiyao
Gao, Lingyan
Abstract
The present invention relates to a method for preparing nano-sized iron phosphate particles, the method comprising the steps of: mixing an iron salt solution and a phosphate solution in a reactor in order to prepare a suspension containing amorphous or crystalline iron phosphate precipitate particles; and adding a shearing force to the mixed solution inside the reactor during the mixing step, wherein the suspension containing nano-sized iron phosphate precipitate particles is formed by means of the shearing force and the conditions inside the reactor. According to the present invention, micro-mixing takes place faster than nucleation, which provides an advantage for preparing nanoparticles and for preparing particles having a uniform particle size distribution.
B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
B82Y 40/00 - Manufacture or treatment of nanostructures
3.
NANOMETRIC TIN-CONTAINING METAL OXIDE PARTICLE AND DISPERSION, AND PREPARATION METHOD AND APPLICATION THEREOF
The present invention relates to a nanometric tin-containing metal oxide particle, having a narrow particle size distribution defined by a dispersion degree smaller than 7 and a steepness ratio smaller than 3. The present invention further relates to a dispersion, a coating, a film, glasswork and similar containing said particle. In addition, the present invention further provides a method for preparing the particle and the dispersion. The nanometric tin-containing metal oxide particle and the dispersion thereof of the present invention can be used in window glass for housing, buildings, automobiles, ships and similar, and ensures high transparency while providing excellent blocking of infrared light for control of sunlight and thermal radiation properties.
There is disclosed a process of making metal chalcogenide particles. The process comprises the steps of reacting a metal salt solution with a precipitant solution under conditions to form metal chalcogenide particles and by-product thereof, coating the metal chalcogenide particles with a surfactant; and separating the surfactant coated chalcogenide particles from the by-product to obtain metal chalcogenide particles substantially free of by-product.
A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.
B01J 2/06 - Processes or devices for granulating materials, in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
B01J 14/00 - Chemical processes in general for reacting liquids with liquids; Apparatus specially adapted therefor
6.
Process for making nano-sized and micro-sized precipitate particles
There is disclosed a process of making nano-sized or micro-sized precipitate particles. The process comprising the steps of mixing, in a reaction zone, a metal salt solution with a precipitant solution to form a precipitate, said precipitate being at least one of a metal chalcogenide, metal hydroxide and metal oxide; and applying a shear force to said mixing solutions in said reaction zone during said mixing step, wherein said shear force and the conditions within said reaction zone form said nano-sized or micro-sized precipitate particles.
There is disclosed a process of making metal chalcogenide particles. The process comprises the steps of reacting a metal salt solution with a precipitant solution under conditions to form metal chalcogenide particles and by-product thereof, coating the metal chalcogenide particles with a surfactant; and separating the surfactant coated chalcogenide particles from the by-product to obtain metal chalcogenide particles substantially free of by-product.
A process of making micro-sized protein particles comprising the step of drying nano-sized protein particles suspended in a liquid medium under conditions to agglomerate the nano-sized protein particles and thereby form micro-sized protein particles.
A process for making micro-sized or nano-sized particles of one or more statin compounds, the process comprising the step of: (a) applying a shear force to (i) a statin solution comprising one or more statin compounds, and (ii) a statin-insoluble liquid in which said statin compounds are insoluble or at least partially insoluble, said applying being undertaken under conditions to form said micro-sized or nano-sized particles of said statin compounds.
There is disclosed a process of making nano-sized or micro-sized precipitate particles. The process comprising the steps of mixing, in a reaction zone, a metal salt solution with a precipitant solution to form a precipitate, said precipitate being at least one of a metal chalcogenide, metal hydroxide and metal oxide; and applying a shear force to said mixing solutions in said reaction zone during said mixing step, wherein said shear force and the conditions within said reaction zone form said nano-sized or micro-sized precipitate particles.
A process of making dispersant-coated carbon particles comprising the steps of providing a liquid mixture comprising carbon particles and a dispersant, and imparting a shear force to the liquid mixture to thereby form said dispersant-coated carbon particles.
A process for preparation of particles of an inhalable drug is described. The process comprises combining a first liquid and a second liquid in a region of high shear, whereby the first liquid and the second liquid interact to form the particles of the drug. One of the first and second liquids comprises the drug or a precursor thereof. In the case where one of the liquids comprises the precursor, the other of the first and second liquids comprises a reagent which reacts with the precursor under high shear conditions to form particles of the drug. In the case where one of the liquids comprises the drug, the other of the first and second liquids comprises a liquid which, when mixed with the liquid containing the drug under high shear, forms particles of the drug.
A61J 3/02 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
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