Salmonid alphavirus (SAV) is an important pathogen affecting the aquaculture of Salmonid fish. Vaccines based on DNA plasmids expressing a SAV antigen have been described. However these are difficult to prepare at large scale and at the desired quality level. Also, they are commonly administered at relatively high amounts of plasmid per animal dose. This makes such DNA vaccines less affordable for this market. The invention discloses an improved plasmid that allows effective use as a DNA vaccine against SAV, but at a much reduced amount of DNA per dose. The plasmid contains a gene encoding a bacterial enzyme: Fab.
The present invention provides caninized rat antibodies to canine IL-31 receptor alpha that have a high binding affinity for canine IL-31 receptor alpha, and that can block the binding of canine IL-31 to canine IL-31 receptor alpha. The present invention further provides the use of the antibodies for the treatment of atopic dermatitis in dogs.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
The present disclosure relates generally to treatment of central nervous system disorders associated with phosphodiesterase 10A (PDE10A) such as schizophrenia, bipolar disease, and Alzheimer's disease, as therapeutics for neurological and psychiatric disorders. This disclosure provides controlled-release formulations of 2-methyl-N-((5-methyl-1,3,4-thiadiazol-2-yl)methyl)-6-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-4-amine (Compound A) and their use in the treatment of schizophrenia and other psychiatric disorders that improves the tolerability profile.
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
The present invention provides canine antibodies that bind to canine interleukin-13 (canine IL-13) that have a high binding affinity for canine IL-13 and that can block the binding of canine IL-13 to the canine Type II heterodimer IL-4 receptor. The present invention also provides methods of using the antibodies of the present invention in the treatment of atopic dermatitis in dogs.
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
A61K 39/00 - Medicinal preparations containing antigens or antibodies
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
An improved process to produce large isoxazoline compound particles which comprises initiating crystallization and then maintaining the temperature of the crystallization in the metastable region by removing, reheating and recycling a portion of the solvent thereby allowing the existing crystals to grow larger while minimizing the formation of newer smaller crystals.
C07D 261/04 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
32.
A METHOD TO PRESERVE VIRUS LIKE PARTICLES OF FOOT AND MOUTH DISEASE VIRUS
The invention pertains to a method to preserve recombinant virus-like particles (VLPs) of Foot and mouth disease virus (FMDV), which VLPs include one or more stabilizing mutations, the method comprising formulating the recombinant VLPs in an aqueous solution that comprises 1-50% (v/v) glycerol and thereafter cooling the solution to a temperature of at least -20˚C. The invention also pertains to an aqueous formulation comprising virus like particles of Foot and mouth disease virus, and to the use of this formulation as a vaccine to protect an animal against an infection with Foot and mouth disease virus.
The present invention relates to the field of veterinary vaccines, more specifically to a DNA vaccine for fish against piscine myocarditis virus (PMCV). In particular, the invention relates to a nucleic acid comprising a nucleotide sequence encoding a PMCV ORF3 protein or a variant or fragment thereof, with modifications in a specific region, as well as to a DNA expression vector comprising the nucleic acid sequence encoding the modified ORF 3, and to medical uses of said DNA expression vector as a vaccine for fish against PMCV.
A system for opening ampoules, the system comprising a beam comprising at least one opening for receiving part of an ampoule and an ampoule carrier for holding one or more ampoules. The system is configured to rotate the beam relative to the carrier, such that the rotation causes opposite sides of said opening to apply pressure to said received ampoule held by the carrier, to thereby break off said part of the ampoule received by the opening.
The present invention relates to a nucleic acid construct that encodes, in this order, a first Swine influenza A (IAV-S) hemagglutinin (HA) antigen of the Scot/94 lineage and a second Swine influenza A (IAV-S) hemagglutinin (HA) antigen of the Eurasian avian-like (EA) lineage, and a nucleic acid construct that encodes, in this order, a first IAV-S HA antigen of the Gent/84 lineage and a second IAV-S HA antigen of pandemic09 (pdm09) lineage. In other embodiments, the present invention relates to RNA replicon particles comprising one or both nucleic acid constructs, an immunogenic composition, such as a vaccine, which may be used against influenza A virus infections, and comprising the replicon particles. Further provided are methods of making the vaccine and use of the vaccine.
A new scalable synthesis for the preparation of endochin-like quinolone compounds of Formula (I), wherein R is H, Cl or F, and R2 is C1-C2 alkyl, wherein the synthesis comprises is a process for preparing a compound of Formula (5) wherein R1 is C1-C2 alkyl, preferably C1 alkyl.
A new scalable synthesis for the preparation of endochin-like quinolone compounds of Formula (I), wherein R is H, Cl or F, and R2 is C1-C2 alkyl, wherein the synthesis comprises is a process for preparing a compound of Formula (5) wherein R1 is C1-C2 alkyl, preferably C1 alkyl.
C07C 67/31 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
The present invention is directed to providing a canine with protective immunity against Leptospira serovar Australis with a vaccine that comprises a non-Australis leptospira serovar.
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
05 - Pharmaceutical, veterinary and sanitary products
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
A novel synthesis of ethyl 3-amino-l-((3R,4S)-4-cyanotetrahydro-2H- pyran-3-yl)-lH-pyrazole-4-carboxylate, an intermediate used in the manufacturing of atinvicitinib, without the use of chiral chromatographic separation.
C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
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Medicines and pharmaceutical preparations for human use, namely, contraceptives; contraceptive pharmaceutical preparations contained in and released from an intrauterine device Intra-uterine contraceptive devices containing copper
A vaccine composition comprising a virus antigen wherein the composition comprises less than 5% serum, wherein the virus antigen is a whole virus or derived from a whole virus. the vaccine composition reduces, prevents or avoids cross-stitch spinal deformity in the treated animal.
A genderless interface connector pull tool is used for removing a membrane from a genderless interface connector. The tool may include a clamp and a hand grip. The clamp is configured to clamp a genderless interface connector and may include a top clamp coupled with a bottom clamp, and one or more rails located on a top surface of the top clamp. The hand grip may include a grip head which is formed with a hook and one or more openings. The hook is configured to engage with a tab of the genderless interface connector that is connected to a membrane. The one or more openings are dimensioned to fit with the one or more rails so that the hand grip can slide on the rails to pull the tab. Thus, the membrane connected to the tab can be removed from the genderless interface connector along the rails'direction.
B25B 27/02 - Hand tools or bench devices, specially adapted for fitting together or separating parts or objects whether or not involving some deformation, not otherwise provided for for connecting objects by press fit or detaching same
An oral liquid liquid pharmaceutical composition comprising a) a pharmaceutically effective amount of a compound of Formula (I) or a salt thereof, b) a poloxamer, and c) a solvent.
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
The present invention generally relates to canine IgG antibodies or antigen binding proteins thereof, comprising a canine IgG modified fragment crystallizable region (Fc region) that has an enhanced half-life due to one or more specific amino acid substitutions in the Fc region. Specifically, the present invention relates to canine antibodies and antigen binding fragments thereof, that bind canine interleukin-31 receptor alpha (IL31RA), comprising a canine fragment crystallizable region (cFc) that comprises two, three, four or more specific amino acids at defined positions, such as 428, 434, 436, 438 and 440 in the cFc region. Pharmaceutical compositions that comprise these antibodies are also provided.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
61.
AN ORAL LIQUID PHARMACEUTICAL COMPOSITION OF ERTUGLIFLOZIN
An oral liquid pharmaceutical composition comprising a) a pharmaceutically effective amount of a compound of Formula (I) or a salt thereof, b) a polyethylene glycol (PEG), and c) a solvent wherein in the pH of the oral liquid pharmaceutical composition is between about 3.0 to about
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
The present invention generally relates to canine IgG antibodies or antigen binding proteins thereof, comprising a canine IgG modified fragment crystallizable region (Fc region) that has an enhanced half-life due to one or more specific amino acid substitutions in the Fc region. Specifically, the present invention relates to canine antibodies that bind canine interleukin-31 receptor alpha (IL31RA), comprising a canine fragment crystallizable region (cFc) that comprises an amino acid residue other than glutamine (Q) at position 311. Pharmaceutical compositions that comprise these antibodies are also provided.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61P 37/00 - Drugs for immunological or allergic disorders
63.
CANINIZED IL31Rα ANTIBODIES WITH AN EXTENDED HALF LIFE
The present invention generally relates to canine IgG antibodies or antigen binding proteins thereof, comprising a canine IgG modified fragment crystallizable region (Fc region) that has an enhanced half-life due to one or more specific amino acid substitutions in the Fc region. Specifically, the present invention relates to canine antibodies that bind canine interleukin-31 receptor alpha (IL31RA), comprising a canine fragment crystallizable region (cFc) that comprises an amino acid residue other than Leucine at position 252. Pharmaceutical compositions that comprise these antibodies are also provided.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61P 37/00 - Drugs for immunological or allergic disorders
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A vaccine composition comprising a virus antigen wherein the composition comprises less than 5% serum, wherein the virus antigen is a whole virus or derived from a whole virus. the vaccine composition reduces, prevents or avoids cross-stitch spinal deformity in the treated animal
S. suisS. suis bacteria. The invention also pertains to methods of preparing the vaccine formulation, preferably wherein the method comprises a step of lyophilizing the vaccine formulation.
The present invention relates to an oral liquid veterinary pharmaceutical composition comprising an isoxazoline compound selected from the group consisting of fluralaner, afoxolaner, lotilaner, and sarolaner, designed to effectively treat and control ectoparasite infestations in livestock, specifically cattle. The composition is formulated as a ready-to-use aqueous suspension that includes a viscosity agent, surfactant, and suspending agent.
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A system for estimating greenhouse gas emission in an environment housing an animal population, the system comprising: one or more monitoring devices configured to
monitor parameters of members of the animal population; a data repository comprising one or more records, each of the records (i) being associated with a respective member of the members, and (ii) including one or more parameters of the respective member as monitored by at least one of the monitoring devices over time; and a processing circuitry configured to: obtain at least a subset of the records, the subset being associated with a
group of members of the animal population; determine one or more greenhouse gas emission affecting parameters based on the subset; estimate an amount of greenhouse gas emission in the environment utilizing the greenhouse gas emission affecting parameters; and perform an action utilizing the estimated amount of greenhouse gas emission in the environment.
The present application relates to crystalline forms of cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4- carboxamide and processes for the preparation thereof. The compound is useful for the treatment of JAK-mediated diseases or conditions such as atopic dermatitis.
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
09 - Scientific and electric apparatus and instruments
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Downloadable computer software for enabling patients to request, receive, track shipment of, and manage prescriptions and orders for pharmaceuticals.; Downloadable computer software for receiving, managing, filling, and providing information about prescription pharmaceutical orders Mail order pharmacy services; Pharmacy services; Online retail pharmacy services Online computer software for enabling patients to request, receive, track shipment of, and manage prescriptions and orders for pharmaceuticals.; Online computer software for receiving, managing, filling, and providing information about prescription pharmaceutical orders Healthcare services; Telemedicine services; Providing medical information in the field of healthcare, pharmaceuticals, medicines, health conditions, diseases, disorders, and treatment options.
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
42 - Scientific, technological and industrial services, research and design
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Downloadable educational course materials in the field of HIV; Downloadable written articles in the field of HIV Printed educational course materials in the field of HIV; Printed articles in the field of HIV Providing a website featuring technology that enables users to receive emotional support, information, education and practical assistance for patients with HIV, their loved ones, caregivers and professionals Providing a website featuring information in the field of HIV health; Providing a website featuring information in the field of the diagnosis and treatment of HIV
The present invention provides caninized murine antibodies against canine CTLA-4 that have specific sequences and a high binding affinity for canine CTLA-4. The present invention further provides epitopes of canine CTLA-4 for caninized murine antibodies against canine CTLA-4. The invention also relates to use of these antibodies in the treatment of cancer in canines and other companion animals.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorde; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
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Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment and prevention of bone, cardiovascular, central nervous system, dermatological, endocrine, hematological, hepatological, immunological, gastrointestinal, genitourinary, gynecological, metabolic, musculoskeletal, nephrological, neurological, oncological, ophthalmic, retinal, psychiatric, pulmonary, renal, respiratory, and urological diseases and disorders; Pharmaceutical preparations for the treatment and prevention of autoimmune diseases, asthma, cancer and tumors, chronic cough, diabetes, hypertension, insomnia, intestinal infections, skin disorders, and urinary incontinence; Inhalers filled with pharmaceutical preparations for the treatment of cardiovascular diseases and disorders; Antibacterial pharmaceuticals; Antibiotics; Antifungal preparations; Anti-infectives; Anti-inflammatories; Antiparasitics; Antivirals; Human vaccine preparations
