Abstract

The invention relates to a method for opening and discharging an electrochemical cell of an ion insertion-deinsertion battery, comprising a casing in which a negative electrode, a positive electrode, a separator and an electrolyte are accommodated, wherein the method comprises the following operations: opening the electrochemical cell at one or more regions of the casing, wherein at least the one or more opening regions are brought into contact with a liquid L1, then discharging the electrochemical cell by bringing the cell into contact with a liquid L2, and wherein the method is characterised in that: - the liquid L1 comprises an alcohol-based solvent and optionally a redox mediator, while the liquid L2 comprises an alcohol-based solvent together with a redox mediator; and - the liquids L1 and L2 are free of chlorine. The invention also relates to a method for recycling an ion insertion-deinsertion battery implementing this opening and discharging method. The method is intended for use in the recycling of lithium-ion, sodium-ion, potassium-ion, calcium-ion or magnesium-ion batteries.

IPC Classes  ?

• H01M 6/52 - Reclaiming serviceable parts of waste cells or batteries
• C22B 1/00 - Preliminary treatment of ores or scrap
• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• C22B 26/12 - Obtaining lithium
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators

Abstract

The invention relates to a method for purifying a battery-electrode active material, comprising the following steps: a) providing an active material to be purified, wherein the active material to be purified comprises a metal oxide, aluminum impurities and copper impurities, b) dissolving the aluminum impurities by immersing the active material to be purified in a soda solution at a concentration selected at an effective value to achieve dissolution of the aluminum impurities, and c) dissolving the copper impurities by immersing the active material to be purified in an ammonia solution having an effective value to achieve dissolution of the copper impurities, whereby a purified active material is obtained. The invention also relates to a method for regenerating a spent battery-electrode active material that employs this purification method.

IPC Classes  ?

• H01M 10/54 - Reclaiming serviceable parts of waste accumulators
• C22B 3/12 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in inorganic alkaline solutions
• C22B 3/14 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in inorganic alkaline solutions containing ammonia or ammonium salts
• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• C22B 15/00 - Obtaining copper
• C22B 21/00 - Obtaining aluminium

Abstract

222222O is oxidized to oxygen, and d) recovering the CO at the outlet of the cathode compartment (2), the deep eutectic solvent being chosen from a mixture of at least one ammonium salt and of at least one amine, a mixture of at least one ammonium salt and of at least one polyol, and a combination of these mixtures.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
• C25B 1/23 - Carbon monoxide or syngas
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/065 - Carbon
• C25B 11/081 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the element being a noble metal
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes
• C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms

Abstract

The present invention relates to a material in the form of porous polymer beads with open porosity, characterised in that said material comprises at least one dialkyl sulphide possibly combined with at least one alkyl aniline in at least a portion of the pores of said polymer beads. The present invention also relates to a method for preparing such a material and to the use thereof for extracting palladium and/or rhodium and/or silver from a solution containing same.

IPC Classes  ?

• C22B 3/24 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means by adsorption on solid substances, e.g. by extraction with solid resins
• B01J 20/26 - Synthetic macromolecular compounds
• B01J 20/32 - Impregnating or coating
• C22B 3/42 - Treatment or purification of solutions, e.g. obtained by leaching by ion-exchange extraction
• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• C22B 11/02 - Obtaining noble metals by dry processes
• C22B 11/00 - Obtaining noble metals

Abstract

The invention relates to a method for recovering one or more metals selected from among technetium, ruthenium, palladium and rhenium from an aqueous solution, which method comprises precipitating the one or more metals from the solution by adding a reagent to the solution, followed by collecting the resulting precipitate, and which method is characterised in that the reagent comprises – or consists of – a mixture of 1,10-phenanthroline and a nickel(II) salt selected from among nickel(II) nitrate and nickel(II) sulphate. The method applies to the recovery of all or some of the technetium, ruthenium and/or palladium present in aqueous solutions of fission products, prior to operations for conditioning the fission products by vitrification; and to the recovery of all or some of the ruthenium, palladium and/or rhenium from solutions obtained through the treatment of industrial and/or urban waste with nitric acid.

IPC Classes  ?

• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• C22B 11/00 - Obtaining noble metals
• C22B 60/00 - Obtaining metals of atomic number 87 or higher, i.e. radioactive metals
• C22B 61/00 - Obtaining metals not elsewhere provided for in this subclass
• G21F 9/04 - Treating liquids
• G21C 19/46 - Aqueous processes

Abstract

41212 linear or branched alkyl group, R2188 linear or branched alkyl group and R311212 linear or branched alkyl group. The invention also relates to the organophosphorus compounds themselves. Uses: recycling of waste from electrical and electronic equipment (WEEE), in particular waste from spent lithium-ion electrochemical batteries with a view to reclaiming the manganese contained in this waste; recovering manganese from natural sources of manganese.

IPC Classes  ?

• C22B 3/38 - Treatment or purification of solutions, e.g. obtained by leaching by liquid-liquid extraction using organic compounds containing phosphorus
• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• C22B 3/00 - Extraction of metal compounds from ores or concentrates by wet processes
• C22B 47/00 - Obtaining manganese
• C07F 9/40 - Esters thereof

Abstract

The invention relates to a material comprising porous microspheres on an actinide oxide basis, which is obtained by an internal gelation method. It also relates to the uses of this material in the manufacture of nuclear fuels, in particular as a sintering additive in the manufacture of pellets of an MOX (mixed oxide) type nuclear fuel and, more specifically, as a pore-forming agent replacing the pore-forming agent conventionally used in said manufacture, namely azodicarbonamide.

IPC Classes  ?

• G21C 3/62 - Ceramic fuel

Abstract

A PSMA-targeting conjugate or a pharmaceutically acceptable salt which may be used either for preparing a radiopharmaceutical or, once labeled with a radionuclide, as a radiopharmaceutical. The conjugate is of formula (I): A1-L1-Ch-L2-A2 (I) wherein: Ch is a chelator, L1 and L2, identical or different, are a linker whereas A1 and A2, identical or different, are a urea-based PSMA ligand.

IPC Classes  ?

• A61K 51/04 - Organic compounds
• A61P 35/00 - Antineoplastic agents

IPC Classes  ?

• B09B 3/35 - Shredding, crushing or cutting
• B09B 101/16 - Batteries
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 10/052 - Li-accumulators
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• H01M 10/0569 - Liquid materials characterised by the solvents
• H01M 10/44 - Methods for charging or discharging
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators

Abstract

The invention relates to a method for opening and discharging an electrochemical generator (10) comprising a negative electrode containing lithium or sodium and a positive electrode optionally containing lithium or sodium, the method comprising the following successive steps: - opening the electrochemical generator (10) in a cutting zone, with a cutting element (20), preferably having an electrical resistance greater than 100 mΩ, the electrochemical generator being opened while spraying the cutting zone with a first solution (100), - discharging the electrochemical generator by partially or completely submerging the electrochemical generator (10) in a second solution (200).

IPC Classes  ?

• B09B 3/35 - Shredding, crushing or cutting
• H01M 10/44 - Methods for charging or discharging
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 10/052 - Li-accumulators
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• H01M 10/0569 - Liquid materials characterised by the solvents
• B09B 101/16 - Batteries

Abstract

Device (10) comprising: - a component (20) configured to contain or circulate a solution, the component (20) having a wall (21) made of steel or a nickel-based alloy comprising chromium, - a solution (30), in contact with the wall (21), comprising a mixture of molten chloride salts, the solution also comprising Ti2+ ions and Ti3+ ions, the Ti3+/Ti2+ ratio being between 20/80 and 70/30.

IPC Classes  ?

• C09K 5/02 - Materials undergoing a change of physical state when used
• C09K 5/12 - Molten materials, i.e. materials solid at room temperature, e.g. metals or salts
• C23F 11/18 - Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids using inorganic inhibitors
• C25C 3/28 - Electrolytic production, recovery or refining of metals by electrolysis of melts of titanium, zirconium, hafnium, tantalum or vanadium of titanium
• F24S 20/20 - Solar heat collectors for receiving concentrated solar energy, e.g. receivers for solar power plants
• F24S 80/20 - Working fluids specially adapted for solar heat collectors
• G01N 17/02 - Electrochemical measuring systems for weathering, corrosion or corrosion-protection measurement
• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• G01N 27/416 - Systems
• G21C 1/03 - Fast fission reactors, i.e. reactors not using a moderator cooled by a coolant not essentially pressurised, e.g. pool-type reactors
• G21C 3/54 - Fused salt, oxide, or hydroxide compositions
• G21C 17/022 - Devices or arrangements for monitoring coolant or moderator for monitoring liquid coolants or moderators

Abstract

The invention relates to a device (10) comprising: - a component (20) configured to contain or circulate a solution, the component (20) having a wall (21) made of steel or a nickel-based alloy comprising chromium, - a solution (30), in contact with the wall (21), comprising a mixture of molten chloride salts, the solution also comprising Ti2+ions and Ti3+ions, the Ti3+/Ti2+ ratio being between 20/80 and 70/30.

IPC Classes  ?

• C23F 11/18 - Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids using inorganic inhibitors
• C23F 13/00 - Inhibiting corrosion of metals by anodic or cathodic protection
• F24S 20/20 - Solar heat collectors for receiving concentrated solar energy, e.g. receivers for solar power plants
• F24S 80/20 - Working fluids specially adapted for solar heat collectors
• G21C 1/03 - Fast fission reactors, i.e. reactors not using a moderator cooled by a coolant not essentially pressurised, e.g. pool-type reactors
• G21C 3/54 - Fused salt, oxide, or hydroxide compositions
• G21C 17/022 - Devices or arrangements for monitoring coolant or moderator for monitoring liquid coolants or moderators
• G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
• G01N 17/02 - Electrochemical measuring systems for weathering, corrosion or corrosion-protection measurement
• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• G01N 27/416 - Systems
• C23F 15/00 - Other methods of preventing corrosion or incrustation
• C25C 3/28 - Electrolytic production, recovery or refining of metals by electrolysis of melts of titanium, zirconium, hafnium, tantalum or vanadium of titanium
• C09K 5/02 - Materials undergoing a change of physical state when used
• C09K 5/12 - Molten materials, i.e. materials solid at room temperature, e.g. metals or salts

Abstract

A method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) so prepared are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers.

IPC Classes  ?

• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes

Abstract

A method for transferring a radioisotope which is fixed on a first stationary phase contained in a first chromatography column to a second stationary phase contained in a second chromatography column, to fix the radioisotope on the second stationary phase, wherein the radioisotope is selected from the radioactive isotopes of thorium, radium, lead, bismuth and uranium, the method comprising at least the following steps: a) eluting the radioisotope from the first stationary phase with an aqueous solution A1 comprising a citric acid salt as an agent complexing the radioisotope, whereby an aqueous solution A2 which comprises citrate complexes of the radioisotope is obtained; b) dissociating the citrate complexes of the radioisotope present in the aqueous solution A2 by modifying the pH of the aqueous solution A2, whereby an aqueous solution A3 comprising the decomplexed radioisotope is obtained; c) loading the second stationary phase with the aqueous solution A3; and d) washing at least one the second stationary phase with an aqueous solution A4.

IPC Classes  ?

• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography

Abstract

A conjugate or a pharmaceutically acceptable salt thereof, the conjugate being of formula: C-L-A, wherein C is a chelator, L is a linker covalently bound to the chelator and A is a Gastrin-releasing peptide receptor antagonist covalently bound to the linker, wherein: the chelator is of formula: A conjugate or a pharmaceutically acceptable salt thereof, the conjugate being of formula: C-L-A, wherein C is a chelator, L is a linker covalently bound to the chelator and A is a Gastrin-releasing peptide receptor antagonist covalently bound to the linker, wherein: the chelator is of formula: A conjugate or a pharmaceutically acceptable salt thereof, the conjugate being of formula: C-L-A, wherein C is a chelator, L is a linker covalently bound to the chelator and A is a Gastrin-releasing peptide receptor antagonist covalently bound to the linker, wherein: the chelator is of formula: where the dotted line represents the covalent bond to the linker; the linker is of formula: -β-Ala-β-Ala-; and the Gastrin-releasing peptide receptor antagonist has the amino acid sequence: -DPhe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2.

IPC Classes  ?

• A61K 51/08 - Peptides, e.g. proteins
• A61P 35/00 - Antineoplastic agents

IPC Classes  ?

• C01G 55/00 - Compounds of ruthenium, rhodium, palladium, osmium, iridium, or platinum

Abstract

The invention relates to a process for purifying ruthenium from an aqueous nitric acid solution in which same is present together with technetium and metal impurities, at a concentration at least 10 times lower than that of the technetium. It also relates to a process for producing ruthenium-97 from a technetium-99 target which has been been proton-irradiated beforehand, which process comprises the implementation of the purification process. Application: production of ruthenium-97-based radiopharmaceuticals used in nuclear medicine for the diagnosis of cancer by imaging and the treatment thereof by targeted radiotherapy.

IPC Classes  ?

• C01G 55/00 - Compounds of ruthenium, rhodium, palladium, osmium, iridium, or platinum

Abstract

The invention relates to a method for producing hydrogen by electrochemically reforming an alcohol. This method comprises electrolyzing alcohol in an electrolytic cell comprising an anode, an electrolyte and a cathode, and is characterized in that at least part of the outer surface of the anode comprises one or more radioactive platinoids selected from among palladium, ruthenium and rhodium, these one or more radioactive platinoids being derived from an acidic aqueous solution containing fission products from a spent nuclear fuel.

IPC Classes  ?

• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• B01J 23/40 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of noble metals of the platinum group metals
• C25B 3/07 - Oxygen containing compounds
• C25B 3/23 - Oxidation
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• C25B 11/061 - Metal or alloy
• C25B 11/065 - Carbon
• C25B 11/081 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the element being a noble metal
• C25B 11/097 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds comprising two or more noble metals or noble metal alloys
• C25D 3/50 - ElectroplatingBaths therefor from solutions of platinum group metals
• C25D 7/06 - WiresStripsFoils
• G21C 19/46 - Aqueous processes

Abstract

A method for opening an electrochemical generator (10) comprising a negative electrode (20) containing lithium or sodium and a positive electrode (30) optionally containing lithium or sodium, the method comprising the following successive steps: a) immersing the electrochemical generator (10) in a solution comprising an inert liquid and, optionally, a redox species, referred to as an oxidising redox species, capable of being reduced on the negative electrode so as to discharge the electrochemical generator; b) opening the electrochemical generator in the solution with a cutting element (100) that has an electrical resistance between 1 mΩ and 1 kΩ, and preferably between 5 mΩ and 100 Ω.

IPC Classes  ?

• H01M 6/52 - Reclaiming serviceable parts of waste cells or batteries
• H01M 8/008 - Disposal or recycling of fuel cells
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators

Abstract

A method for opening an electrochemical generator (10) comprising a negative electrode (20) containing lithium or sodium and a positive electrode (30) optionally containing lithium or sodium, the method comprising the following successive steps: a) immersing the electrochemical generator (10) in a solution comprising an inert liquid and, optionally, a redox species, referred to as an oxidising redox species, capable of being reduced on the negative electrode so as to discharge the electrochemical generator; b) opening the electrochemical generator in the solution with a cutting element (100) that has an electrical resistance between 1 m? and 1 k?, and preferably between 5 m? and 100 ?.

IPC Classes  ?

• H01M 6/52 - Reclaiming serviceable parts of waste cells or batteries
• H01M 8/008 - Disposal or recycling of fuel cells

Abstract

A process is for preparing a site-specific bioconjugated antibody of a formula (I): Ab-(Linker-Chelator)n (I). The Linker is an oligopeptide with an N-terminal end. The Chelator is a metal chelating agent. n is a Chelator-to antibody ratio (CAR), wherein 0

IPC Classes  ?

• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
• A61K 47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

Abstract

The invention relates to a method for dissolving a positive electrode material of a battery comprising a step during which the positive electrode material, comprising lithium and optionally cobalt and/or nickel, is submerged in an acid solution having a pH between 0 and 4, the acid solution containing either manganese ions or hydrogen peroxide, by means of which the lithium and optionally the cobalt and/or nickel is dissolved, and the manganese ions are selectively precipitated in the form of manganese oxyhydroxide.

IPC Classes  ?

• C22B 3/08 - Sulfuric acid
• C22B 3/44 - Treatment or purification of solutions, e.g. obtained by leaching by chemical processes
• C22B 26/12 - Obtaining lithium

Abstract

The invention relates to a method for dissolving a positive electrode material of a battery comprising a step during which the positive electrode material, comprising lithium and optionally cobalt and/or nickel, is submerged in an acid solution having a pH between 0 and 4, the acid solution containing either manganese ions or hydrogen peroxide, by means of which the lithium and optionally the cobalt and/or nickel is dissolved, and the manganese ions are selectively precipitated in the form of manganese oxyhydroxide.

IPC Classes  ?

• C22B 3/08 - Sulfuric acid
• C22B 3/44 - Treatment or purification of solutions, e.g. obtained by leaching by chemical processes
• C22B 3/00 - Extraction of metal compounds from ores or concentrates by wet processes
• C22B 26/12 - Obtaining lithium
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators

Abstract

The invention relates to a PSMA-targeting conjugate or a pharmaceutically acceptable salt which may be used either for preparing a radiopharmaceutical or, once labeled with a radionuclide, as a radiopharmaceutical. The conjugate is of formula (I): A1-L1-Ch -L2-A2 (I) wherein: Ch is a chelator, L1 and L2, identical or different, are a linker whereas A1 and A2, identical or different, are an urea-based PSMA ligand. The invention also relates to the uses thereof.

IPC Classes  ?

• A61K 51/04 - Organic compounds

Abstract

The invention relates to a PSMA-targeting conjugate or a pharmaceutically acceptable salt which may be used either for preparing a radiopharmaceutical or, once labeled with a radionuclide, as a radiopharmaceutical. The conjugate is of formula (I): A1-L1-Ch -L2-A2(I) wherein: Ch is a chelator, L1and L2, identical or different, are a linker whereas A1and A2, identical or different, are an urea-based PSMA ligand. The invention also relates to the uses thereof.

IPC Classes  ?

• A61K 51/04 - Organic compounds
• A61P 35/00 - Antineoplastic agents
• C07B 59/00 - Introduction of isotopes of elements into organic compounds

Abstract

The invention relates to a method for securing an electrochemical generator (10) comprising a negative electrode (20) containing lithium or sodium and a positive electrode (30), the method comprising the following successive steps: (a) immersing an electrochemical generator (10) in an ionic liquid solution (100) containing a solvent ionic liquid and, optionally, a redox species, referred to as the oxidising species, capable of being reduced on the negative electrode so as to discharge the electrochemical generator; (b) opening the electrochemical generator with an electrically insulative element, opening being performed in the ionic liquid solution.

IPC Classes  ?

• B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless
• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/40 - Alloys based on alkali metals
• H01M 6/52 - Reclaiming serviceable parts of waste cells or batteries
• H01M 10/052 - Li-accumulators
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• H01M 10/44 - Methods for charging or discharging
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators

Abstract

The invention relates to a method for securing an electrochemical generator (10) comprising a negative electrode (20) containing lithium or sodium and a positive electrode (30), the method comprising the following successive steps: (a) immersing an electrochemical generator (10) in an ionic liquid solution (100) containing a solvent ionic liquid and, optionally, a redox species, referred to as the oxidising species, capable of being reduced on the negative electrode so as to discharge the electrochemical generator; (b) opening the electrochemical generator with an electrically insulative element, opening being performed in the ionic liquid solution.

IPC Classes  ?

• H01M 10/54 - Reclaiming serviceable parts of waste accumulators
• H01M 6/52 - Reclaiming serviceable parts of waste cells or batteries
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/40 - Alloys based on alkali metals
• H01M 10/052 - Li-accumulators
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless
• H01M 10/44 - Methods for charging or discharging
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

Disclosed is a method for discharging an electrochemical generator (10) comprising a negative electrode (20) containing lithium or sodium and a positive electrode (30), the method comprising a discharging step during which the electrochemical generator (10) is brought into contact with an ionic liquid solution (100) containing a solvent ionic liquid and an electrically conductive powder so as to discharge the electrochemical generator (10).

IPC Classes  ?

• H01M 10/54 - Reclaiming serviceable parts of waste accumulators
• H01M 6/52 - Reclaiming serviceable parts of waste cells or batteries
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/40 - Alloys based on alkali metals
• H01M 10/052 - Li-accumulators
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• H01M 10/44 - Methods for charging or discharging
• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

22. The invention also relates to the uses of the conjugate or salt thereof.

IPC Classes  ?

• A61K 51/08 - Peptides, e.g. proteins
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to a conjugate or a pharmaceutically acceptable salt thereof, the conjugate being of formula: C-L-A, wherein C is a chelator, L is a linker covalently bound to the chelator and A is a Gastrin-releasing peptide receptor antagonist covalently bound to the linker, characterized in that: - the chelator is of formula (I): where the dotted line represents the covalent bond to the linker; - the linker is of formula: -?-Ala-?-Ala-; and - the Gastrin-releasing peptide receptor antagonist has the amino acid sequence: -DPhe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2. The invention also relates to the uses of the conjugate or salt thereof.

IPC Classes  ?

• A61K 51/08 - Peptides, e.g. proteins

Abstract

A method for producing lead-212 of very high radiological purity from an aqueous solution comprising thorium-228 and daughters thereof. Manufacture of radiopharmaceuticals based on lead-212, which are useful in nuclear medicine and, in particular, in targeted alpha radiation therapy for the treatment of cancers.

IPC Classes  ?

• B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
• B01D 15/26 - Selective adsorption, e.g. chromatography characterised by the separation mechanism
• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes

Abstract

A method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) that it can be used to prepare are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers.

IPC Classes  ?

• G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes

Abstract

A method for transferring a radioisotope which is fixed on a first stationary phase contained in a first chromatography column to a second stationary phase contained in a second chromatography column, to fix the radioisotope on the second stationary phase, wherein the radioisotope is selected from the radioactive isotopes of thorium, radium, lead, bismuth and uranium, the method comprising at least the following steps: a) eluting the radioisotope from the first stationary phase with an aqueous solution A1 comprising an agent complexing the radioisotope, whereby an aqueous solution A2 which comprises complexes of the radioisotope is obtained; b) dissociating the complexes of the radioisotope present in the aqueous solution A2 by modifying the pH of the aqueous solution A2, whereby an aqueous solution A3 comprising the decomplexed radioisotope is obtained; c) loading the second stationary phase with the aqueous solution A3; and d) washing at least one the second stationary phase with an aqueous solution A4.

IPC Classes  ?

• G01N 30/46 - Flow patterns using more than one column
• G01N 30/18 - Injection using a septum or microsyringe

Abstract

The invention relates to a diaza-18-crown-6 derivative having formula (I): wherein: B is a moiety for a covalent bonding reaction; the two A are identical to each other and are a group of formula (II): where: n = 0 to 4; X1, X2, X3, X4and X5are N, a -CH group or a -CR group wherein R is a -P(O)(OR1)(OR2), -P(O)R1(OR2), -P(O)R1R2, -P(S)(SR1)(SR2), -P(S)R1(SR2) or -P(S)R1R2group in which R1and R2144 alkyl group, provided that no more than two of X1, X2, X3, X4and X5are N and no more than one of X1, X2, X3, X4and X5 is a -CR group. The invention also relates to a conjugate comprising the diaza-18-crown-6 derivative covalently bonded to a targeting moiety for biological cells, a chelate comprising radium chelated by the conjugate, and to uses of the diaza-18-crown-6 derivative, the conjugate and the chelate.

IPC Classes  ?

• A61K 51/08 - Peptides, e.g. proteins
• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• C07D 273/08 - Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups having two nitrogen atoms and more than one oxygen atom
• C07F 3/00 - Compounds containing elements of Groups 2 or 12 of the Periodic Table
• C07F 9/38 - Phosphonic acids [R—P(:O)(OH)2]Thiophosphonic acids

Abstract

Disclosed is a method for selectively separating a carbon-containing material from a mixture comprising a positive electrode and a negative electrode originating from fuel cells and/or electrochemical batteries, the method comprising the following successive steps: a) providing a mixture comprising a positive electrode and a negative electrode, each electrode comprising a current collector, an active material and a binder, the active material of the negative electrode being a carbon-containing material, preferably graphite, b) bringing the mixture comprising the positive electrode and the negative electrode into contact with a separating solution, in the presence of ultrasound, the separating solution comprising a solvent and possibly additives, until the carbon-containing material is selectively separated from the current collector of the negative electrode, the active material of the positive electrode remaining joined to the current collector of the positive electrode.

IPC Classes  ?

• H01M 10/54 - Reclaiming serviceable parts of waste accumulators

Abstract

Disclosed is a method for selectively separating a carbon-containing material from a mixture comprising a positive electrode and a negative electrode originating from fuel cells and/or electrochemical batteries, the method comprising the following successive steps: a) providing a mixture comprising a positive electrode and a negative electrode, each electrode comprising a current collector, an active material and a binder, the active material of the negative electrode being a carbon-containing material, preferably graphite, b) bringing the mixture comprising the positive electrode and the negative electrode into contact with a separating solution, in the presence of ultrasound, the separating solution comprising a solvent and possibly additives, until the carbon-containing material is selectively separated from the current collector of the negative electrode, the active material of the positive electrode remaining joined to the current collector of the positive electrode.

IPC Classes  ?

• H01M 10/54 - Reclaiming serviceable parts of waste accumulators

Abstract

Disclosed is a method for recycling at least one electrode, comprising the following consecutive steps: a) providing at least one electrode comprising a current collector, an active material and, optionally, a binder, b) immersing the at least one electrode in an ionic liquid solution comprising a solvent ionic liquid, in the presence of ultrasound, whereby the active material, and if applicable the binder, is separated from the current collector.

IPC Classes  ?

• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

Disclosed is a method for recycling at least one electrode, comprising the following consecutive steps: a) providing at least one electrode comprising a current collector, an active material and, optionally, a binder, b) immersing the at least one electrode in an ionic liquid solution comprising a solvent ionic liquid, in the presence of ultrasound, whereby the active material, and if applicable the binder, is separated from the current collector.

IPC Classes  ?

• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 10/54 - Reclaiming serviceable parts of waste accumulators

Abstract

The present application concerns a process for preparing a site-specific bioconjugated antibody with a metal Chelator, the bionconjugated antibody and its use in nuclear medicine.

IPC Classes  ?

• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof

Abstract

The present application concerns a process for preparing a site-specific bioconjugated antibody with a metal Chelator, the bionconjugated antibody and its use in nuclear medicine.

IPC Classes  ?

• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
• A61P 35/00 - Antineoplastic agents

Goods & Services

Pharmaceuticals or radiopharmaceuticals, and their components, for medical diagnostic, in particular for locating cancerous tumours; Diagnostic preparations for medical purposes, in particular for locating cancerous tumours Metal tanks and containers for the packaging, transport, storage, and warehousing of radioactive products, radiopharmaceuticals, radiopharmaceutical constituents Industrial radionuclide generators and robots for manufacturing and preparing radiopharmaceuticals Medical apparatus and devices for use in the diagnosis and localization of cancerous tumors and other diseases in the human body, and in the treatment of cancer or viral diseases Research and development, analysis, studies and design relating to pharmaceuticals, radiopharmaceuticals and pharmaceutical and radiopharmaceutical constituents, all for the treatment of diseases and in particular of cancers

Abstract

An apparatus is for the automated production of a daughter radionuclide from a parent radionuclide using a generator comprising a solid medium onto which the parent nuclide is fixed and whereby the daughter nuclide is formed by radioactive decay of the parent nuclide. The apparatus includes a fluid circuit including a chromatography column having a head port and a tail port, at least one connection port for connecting the generator to the fluid circuit, at least one inlet port for connecting fluid sources to the fluid circuit and at least one valve controlled by an electronic control unit for selectively connecting the chromatography column, the connection port and the at least one inlet port in various configurations. The various configurations include a first elution configuration for circulating an A1′ solution exiting the generator and containing the daughter radionuclide, through the chromatography column from the head port to the tail port for loading the chromatography column with the daughter radionuclide; a first washing configuration for circulating an A2 washing solution from a solution inlet through the chromatography column from the head port to the tail port; and a second washing configuration for circulating an A2′ washing solution from a solution inlet through the chromatography column from the tail port to the head port.

IPC Classes  ?

• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
• B01D 15/00 - Separating processes involving the treatment of liquids with solid sorbentsApparatus therefor
• B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
• B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
• B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
• C22B 60/02 - Obtaining thorium, uranium or other actinides
• G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications

Abstract

The invention relates to a method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) that it can be used to prepare are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers.

IPC Classes  ?

• A61K 51/04 - Organic compounds
• B01D 15/08 - Selective adsorption, e.g. chromatography
• C01F 13/00 - Compounds of radium
• C01F 15/00 - Compounds of thorium

Abstract

The invention relates to a method for transferring a radioisotope that is attached to a first stationary phase contained in a first chromatography column to a second stationary phase contained in a second chromatography column, in order to fix the radioisotope to the second stationary phase, wherein the radioisotope is selected from the radioactive isotopes of thorium, radium, lead, bismuth and uranium. Said method comprises at least the following steps: a) eluting the radioisotope from the first stationary phase with an aqueous solution A1 comprising an agent complexing the radioisotope, whereby an aqueous solution A2 is obtained which comprises complexes of the radioisotope; b) dissociating the complexes of the radioisotope present in the aqueous solution A2 by modifying the pH of the aqueous solution A2, whereby an aqueous solution A3 comprising the decomplexed radioisotope is obtained; c) loading the second stationary phase with the aqueous solution A3; and d) carrying out at least one washing of the second stationary phase with an aqueous solution A4.

IPC Classes  ?

• A61K 51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo
• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
• G21G 4/00 - Radioactive sources
• G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications

Abstract

The invention relates to a method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) that it can be used to prepare are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers.

IPC Classes  ?

• A61K 51/04 - Organic compounds
• C01F 15/00 - Compounds of thorium
• G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications
• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes

Abstract

The invention relates to a method for transferring a radioisotope that is attached to a first stationary phase contained in a first chromatography column to a second stationary phase contained in a second chromatography column, in order to fix the radioisotope to the second stationary phase, wherein the radioisotope is selected from the radioactive isotopes of thorium, radium, lead, bismuth and uranium. Said method comprises at least the following steps: a) eluting the radioisotope from the first stationary phase with an aqueous solution A1 comprising an agent complexing the radioisotope, whereby an aqueous solution A2 is obtained which comprises complexes of the radioisotope; b) dissociating the complexes of the radioisotope present in the aqueous solution A2 by modifying the pH of the aqueous solution A2, whereby an aqueous solution A3 comprising the decomplexed radioisotope is obtained; c) loading the second stationary phase with the aqueous solution A3; and d) carrying out at least one washing of the second stationary phase with an aqueous solution A4.

IPC Classes  ?

• A61K 51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo
• G21G 4/00 - Radioactive sources
• G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications
• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes

Abstract

The invention relates to a method for producing x-ray very high purity lead-212 from an aqueous solution comprising thorium-228 and its descendants. Applications: manufacture of radiopharmaceuticals based on lead-212, which are useful in nuclear medicine and, in particular, in targeted alpha radiation therapy for the treatment of cancers.

IPC Classes  ?

• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
• C22B 13/06 - Refining

Abstract

The invention relates to a method for producing x-ray very high purity lead-212 from an aqueous solution comprising thorium-228 and its descendants. Applications: manufacture of radiopharmaceuticals based on lead-212, which are useful in nuclear medicine and, in particular, in targeted alpha radiation therapy for the treatment of cancers.

IPC Classes  ?

• B01D 15/30 - Partition chromatography
• C22B 3/24 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means by adsorption on solid substances, e.g. by extraction with solid resins
• C22B 13/00 - Obtaining lead
• C22B 60/00 - Obtaining metals of atomic number 87 or higher, i.e. radioactive metals
• C22B 60/02 - Obtaining thorium, uranium or other actinides

Abstract

A cancer targeting composition, kit, and method for treatment of cancer cells overexpressing somatostatin receptors is disclosed. The composition includes a radioisotope, a chelator, and a targeting moiety. The chelator includes a nitrogen ring structure including a tetraazacyclododecane, a triazacyclononane, and/or a tetraazabicyclo [6.6.2] hexadecane derivative. The targeting moiety includes a somatostatin receptor targeting peptide. The somatostatin receptor targeting peptide includes an octreotide derivative. The targeting moiety is chelated to the radioisotope by the chelator whereby the cancer cells are targeted for elimination.

IPC Classes  ?

• A61K 51/08 - Peptides, e.g. proteins
• A61P 35/00 - Antineoplastic agents
• A61K 51/04 - Organic compounds
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A process for producing a daughter radionuclide from a parent radionuclide includes a) loading the parent radionuclide on a first solid medium contained in a generator and onto which the parent radionuclide is retained and whereby the daughter radionuclide is formed by radioactive decay of the parent radionuclide; b) eluting this medium with a A0 solution so as to recover a A1 solution comprising the daughter radionuclide; c) optionally adjusting the pH of the A1 solution so as to obtain a A1′ solution, d) loading this A1 or A1′ solution onto the head of a second solid medium contained in a chromatography column; e) first washing said second solid medium with a A2 solution; f) second washing said second solid medium with a A2′ solution; g) eluting the daughter radionuclide with a A3 solution. The first washing step is conducted from head to tail of the column and the second washing step and the second eluting step are conducted from tail to head of the column.

IPC Classes  ?

• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
• B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
• B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
• B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
• C22B 60/02 - Obtaining thorium, uranium or other actinides
• G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications

Abstract

The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterised in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.

IPC Classes  ?

• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
• G01N 30/84 - Preparation of the fraction to be distributed
• G01D 15/12 - Magnetic recording elements
• G01N 30/06 - Preparation
• B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• C22B 13/02 - Obtaining lead by dry processes
• C22B 13/06 - Refining
• C22C 11/00 - Alloys based on lead
• B01D 15/12 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
• G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications

Abstract

The present invention concerns a process for producing a daughter radionuclide from a parent radionuclide comprising the purification of the daughter radionuclide on a chromatography column, as well as the apparatus for carrying out such process.

IPC Classes  ?

• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes

Abstract

The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterized in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.

IPC Classes  ?

• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• C22B 13/02 - Obtaining lead by dry processes
• C22B 13/06 - Refining
• C22C 11/00 - Alloys based on lead
• G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications