The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
C08G 65/334 - Polymers modified by chemical after-treatment with organic compounds containing sulfur
The present invention relates a pharmaceutical formulation comprising a long-acting growth hormone for use in a method of treating growth hormone deficiency, wherein the long-acting growth hormone formulation is administered to a patient in a bracketed dosage regimen, to a multitude of unit dosage forms comprising a long-acting growth hormone formulation, wherein the unit dosage forms comprise increasing amounts of growth hormone equivalents and wherein the amount of growth hormone equivalents increases by at least 10% between one unit dosage form and the next higher dosage form; their use in a method of treating growth hormone deficiency and method of treating growth hormone deficiency in a bracketed dosing regimen.
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 9/19 - Particulate form, e.g. powders lyophilised
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Software and application software for use in the provision of medical advice and advice on medical treatment, patient assistance and health insurance in the field of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders; Application software for mobile phones, application software for tablet computers, Application software for hand-held computers and personal computer application software, namely, Downloadable application software for sharing information related to hypoparathyroidism growth-related disorders, endocrinological disorders and bone disorders and the treatment of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders for use by patients with growth-related disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders. Education and instruction services; Arranging and conducting of conferences, symposiums, conferences, seminars, workshops, lectures and online education seminars and guides about pharmaceutical, medical and healthcare topics; Publication and reporting, electronic publication about pharmaceutical, medical and healthcare topics; Teaching, namely, Organisation of educational programmes for patients and healthcare providers in relation to hypoparathyroidism growth-related disorders, endocrinological disorders and bone disorders and the treatment of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders for use by patients with growth-related disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders. Provision and dissemination of information and Consultancy in relation to the following fields: Growth hormone deficiency, endocrinological disorders, and bone and skeletal disorders, Diagnosis and treatments, Medical screening, Medicine, Health and pharmaceutical products; Patient support programs, namely, the provision of health information to patients and healthcare providers in the areas of growth hormone deficiency, endocrinological disorders, and bone and skeletal disorders, diagnosis and treatment, including the provision of information on self-administration of medication; Provision of an online website with information related to hypoparathyroidism growth-related disorders, endocrinological disorders and bone disorders and treatment of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders for use by patients with growth-related disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders.
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Software and application software for use in the provision of medical advice and advice on medical treatment, patient assistance and health insurance in the field of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders; Application software for mobile phones, application software for tablet computers, Application software for hand-held computers and personal computer application software, namely A downloadable application software for sharing information related to hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders and the treatment of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders for use by patients with growth-related disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders. Education and instruction services; Arranging and conducting of conferences, symposiums, conferences, seminars, workshops, lectures and online education seminars and guides about pharmaceutical, medical and healthcare topics; Publication and reporting, electronic publication about pharmaceutical, medical and healthcare topics; Teaching, namely, Organisation of educational programs for patients and healthcare providers in relation to hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders and the treatment of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders for use by patients with growth-related disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders. Provision and dissemination of information and Consultancy in relation to the following fields: Growth hormone deficiency, endocrinological disorders, and bone and skeletal disorders, Diagnosis and treatments, Medical screening, Medicine, Health and pharmaceutical products; Patient support programs, namely, the provision of health information to patients and healthcare providers in the areas of growth hormone deficiency, endocrinological disorders, and bone and skeletal disorders, diagnosis and treatment, including the provision of information on self-administration of medication; Provision of an online website with information related to hypoparathyroidism growth-related disorders, endocrinological disorders and bone disorders and treatment of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders for use by patients with growth-related disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth-related disorders, endocrinological disorders and bone disorders.
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable computer software and downloadable computer application software for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to hypoparathyroidism, growth disorders, endocrine disorders and bone disorders and the treatment of hypoparathyroidism, growth disorders, endocrine disorders, bone disorders for use by patients with growth hormone disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders Educational and teaching services, namely, providing conferences, symposiums, seminars, workshops, lectures, classes and online education seminars in the field of pharmaceuticals, medicine, and health care; Publication of non-downloadable electronic publications in the nature of advisory board reports, magazines, journals and articles in the field of pharmaceutical, medical and healthcare topics; Editorial reporting services; News syndication reporting; Educational services, namely, conducting educational programs for patients and healthcare providers related to hypoparathyroidism, growth disorders, endocrine disorders and bone disorders and the treatment of hypoparathyroidism, growth disorders, endocrine disorders, bone disorders for use by patients with growth hormone disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders Providing and sharing of medical information and advice relating to growth hormone deficiency, endocrinological disorders, and bone and skeletal disorders, diagnosis and treatment, medical screening, medicine, health and pharmaceutical products; Patient support program, namely, providing health care information to patients and healthcare providers in the field of growth hormone deficiency, endocrine disorders, and bone and skeletal disorders diagnosis and treatment including providing information on self-administering medications; Providing an online website featuring medical and healthcare information related to hypoparathyroidism, growth disorders, endocrine disorders and bone disorders and the treatment of hypoparathyroidism, growth disorders, endocrine disorders, bone disorders for use by patients with growth hormone disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders
09 - Scientific and electric apparatus and instruments
41 - Education, entertainment, sporting and cultural services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable computer software and downloadable computer application software for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to hypoparathyroidism, growth disorders, endocrine disorders and bone disorders and the treatment of hypoparathyroidism, growth disorders, endocrine disorders, bone disorders for use by patients with growth hormone disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders Educational and teaching services, namely, providing conferences, symposiums, seminars, workshops, lectures, classes and online education seminars in the field of pharmaceuticals, medicine, and health care; Publication of non-downloadable electronic publications in the nature of advisory board reports, magazines, journals and articles in the field of pharmaceutical, medical and healthcare topics; Editorial reporting services; News syndication reporting; Educational services, namely, conducting educational programs for patients and healthcare providers related to hypoparathyroidism, growth disorders, endocrine disorders and bone disorders and the treatment of hypoparathyroidism, growth disorders, endocrine disorders, bone disorders for use by patients with growth hormone disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders Providing and sharing of medical information and advice relating to growth hormone deficiency, endocrinological disorders, and bone and skeletal disorders, diagnosis and treatment, medical screening, medicine, health and pharmaceutical products; Patient support program, namely, providing health care information to patients and healthcare providers in the field of growth hormone deficiency, endocrine disorders, and bone and skeletal disorders diagnosis and treatment including providing information on self-administering medications; Providing an online website featuring medical and healthcare information related to hypoparathyroidism, growth disorders, endocrine disorders and bone disorders and the treatment of hypoparathyroidism, growth disorders, endocrine disorders, bone disorders for use by patients with growth hormone disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders
09 - Scientific and electric apparatus and instruments
Goods & Services
Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to hypoparathyroidism, growth disorders, endocrine disorders and bone disorders and the treatment of hypoparathyroidism, growth disorders, endocrine disorders, bone disorders for use by patients with growth hormone disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay information and estimates, providing access to secure medical documents, providing financial support services in the nature of payment processing; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of
hypoparathyroidism; pharmaceutical preparations for the
treatment of growth disorders, pharmaceutical preparations
for the treatment of endocrine disorders, pharmaceutical
preparations for the treatment of bone disorders; diagnostic
preparations for medical use, namely, diagnostic
preparations for identifying and detecting
hypoparathyroidism, endocrine disorders and bone disorders. Downloadable computer software and downloadable computer
programs for use in providing medical advice and advice on
medical treatment, patient assistance and health insurance
in the field of hypoparathyroidism, growth disorders,
endocrine disorders and bone disorders; downloadable
computer application software for mobile phones, tablet
computers, handheld computers and personal computers,
namely, a downloadable software application for sharing
information related to hypoparathyroidism, growth disorders,
endocrine disorders and bone disorders and the treatment of
hypoparathyroidism, growth disorders, endocrine disorders,
bone disorders for use by patients with growth hormone
disorders, hypoparathyroidism and skeletal dysplasia in the
medical field of hypoparathyroidism, growth disorders,
endocrine disorders and bone disorders; downloadable
computer application software for mobile phones, tablet
computers, handheld computers and personal computers,
namely, downloadable software that coordinates the delivery
of health care services between health care providers,
patients and those parties responsible for the payment of
health care services, namely, downloadable software that
allows individuals seeking medical education, information
and services to locate a physician and treatment facility in
their geographic area for medical treatment and allows
physicians and health care professionals to communicate
their authorization and specialization to patients and
parties responsible for payment of healthcare services;
downloadable computer application software for mobile
phones, tablet computers, handheld computers and personal
computers, namely, downloadable software that enables health
care providers to monitor patients, communicate clinical
information relevant to a patient's care, provide and
exchange information concerning patients and the health care
services provided to patients; downloadable software,
downloadable software applications and downloadable mobile
applications for providing co-pay and other financial or
medical access support; downloadable computer software for
providing a communications platform enabling users to share
health and healthcare information; downloadable software,
downloadable software applications and downloadable mobile
applications for the measurement of height, weight, blood
pressure, serum calcium, blood glucose, and heart rate;
downloadable software, downloadable software applications
and downloadable mobile applications for providing,
exchanging, retrieving and analyzing health and healthcare
information; downloadable software for medical purposes,
namely, for formatting, viewing and transmitting medical
data collected and stored on hormone injection pens and
pumps and between said injection pens and pumps and portable
electronic devices; downloadable computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely, a downloadable
software application for providing healthcare-related
information, medication reminders, and tracking medication
dosing history; the foregoing downloadable software related
to pharmaceutical preparations for the treatment of
hypoparathyroidism, growth disorders, endocrine disorders
and bone disorders. dosage management dispensers containing
software for medical information management for guidance and
control of medicines and for therapeutic use in web-based
physical and psychological examination and assessment of
patients remotely and at a clinic. Medical devices for injection, dosage and control of
pharmaceuticals, namely, medical devices for injection,
dosage measurement and monitoring of pharmaceuticals for the
treatment of hypoparathyroidism, growth disorders, endocrine
disorders and bone disorders; syringes for medical purposes
and for injections; syringes for injection for medical and
surgical use, namely, syringes in the form of pens for
surgical use; digitally connected medical devices for
monitoring the dispensation of pharmaceutical preparations
for use in connection with management of growth hormone
disorders, hypoparathyroidism and skeletal dysplasia;
medical apparatus, namely, infusion and injection devices
for administering drugs; software controlled drug delivery
medical devices for medicine dosage and for providing
web-based medical information for physical and psychological
examination and assessment of patients remotely and at a
clinic; software controlled drug delivery medical devices
for dosage management, and for use in medical information
management for guidance and control of medicines and for
therapeutic use in web-based physical and psychological
examination and assessment of patient remotely and at a
clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of
hypoparathyroidism; pharmaceutical preparations for the
treatment of growth disorders, pharmaceutical preparations
for the treatment of endocrine disorders, pharmaceutical
preparations for the treatment of bone disorders; diagnostic
preparations for medical use, namely, diagnostic
preparations for identifying and detecting
hypoparathyroidism, endocrine disorders and bone disorders. Downloadable computer software and downloadable computer
programs for use in providing medical advice and advice on
medical treatment, patient assistance and health insurance
in the field of hypoparathyroidism, growth disorders,
endocrine disorders and bone disorders; downloadable
computer application software for mobile phones, tablet
computers, handheld computers and personal computers,
namely, a downloadable software application for sharing
information related to hypoparathyroidism, growth disorders,
endocrine disorders and bone disorders and the treatment of
hypoparathyroidism, growth disorders, endocrine disorders,
bone disorders for use by patients with growth hormone
disorders, hypoparathyroidism and skeletal dysplasia in the
medical field of hypoparathyroidism, growth disorders,
endocrine disorders and bone disorders; downloadable
computer application software for mobile phones, tablet
computers, handheld computers and personal computers,
namely, downloadable software that coordinates the delivery
of health care services between health care providers,
patients and those parties responsible for the payment of
health care services, namely, downloadable software that
allows individuals seeking medical education, information
and services to locate a physician and treatment facility in
their geographic area for medical treatment and allows
physicians and health care professionals to communicate
their authorization and specialization to patients and
parties responsible for payment of healthcare services;
downloadable computer application software for mobile
phones, tablet computers, handheld computers and personal
computers, namely, downloadable software that enables health
care providers to monitor patients, communicate clinical
information relevant to a patient's care, provide and
exchange information concerning patients and the health care
services provided to patients; downloadable software,
downloadable software applications and downloadable mobile
applications for providing co-pay and other financial or
medical access support; downloadable computer software for
providing a communications platform enabling users to share
health and healthcare information; downloadable software,
downloadable software applications and downloadable mobile
applications for the measurement of height, weight, blood
pressure, serum calcium, blood glucose, and heart rate;
downloadable software, downloadable software applications
and downloadable mobile applications for providing,
exchanging, retrieving and analyzing health and healthcare
information; downloadable software for medical purposes,
namely, for formatting, viewing and transmitting medical
data collected and stored on hormone injection pens and
pumps and between said injection pens and pumps and portable
electronic devices; downloadable computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely, a downloadable
software application for providing healthcare-related
information, medication reminders, and tracking medication
dosing history; the foregoing downloadable software related
to pharmaceutical preparations for the treatment of
hypoparathyroidism, growth disorders, endocrine disorders
and bone disorders. dosage management dispensers containing
software for medical information management for guidance and
control of medicines and for therapeutic use in web-based
physical and psychological examination and assessment of
patients remotely and at a clinic. Medical devices for injection, dosage and control of
pharmaceuticals, namely, medical devices for injection,
dosage measurement and monitoring of pharmaceuticals for the
treatment of hypoparathyroidism, growth disorders, endocrine
disorders and bone disorders; syringes for medical purposes
and for injections; syringes for injection for medical and
surgical use, namely, syringes in the form of pens for
surgical use; digitally connected medical devices for
monitoring the dispensation of pharmaceutical preparations
for use in connection with management of growth hormone
disorders, hypoparathyroidism and skeletal dysplasia;
medical apparatus, namely, infusion and injection devices
for administering drugs; software controlled drug delivery
medical devices for medicine dosage and for providing
web-based medical information for physical and psychological
examination and assessment of patients remotely and at a
clinic; software controlled drug delivery medical devices
for dosage management, and for use in medical information
management for guidance and control of medicines and for
therapeutic use in web-based physical and psychological
examination and assessment of patient remotely and at a
clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceutical preparations for the treatment of hypoparathyroidism; pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting hypoparathyroidism, endocrine disorders and bone disorders.
(2) Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medical treatment, patient assistance and health insurance in the field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to hypoparathyroidism, growth disorders, endocrine disorders and bone disorders and the treatment of hypoparathyroidism, growth disorders, endocrine disorders, bone disorders for use by patients with growth hormone disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their authorization and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay and other financial or medical access support; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders. dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic.
(3) Medical devices for injection, dosage and control of pharmaceuticals, namely, medical devices for injection, dosage measurement and monitoring of pharmaceuticals for the treatment of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely, syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism and skeletal dysplasia; medical apparatus, namely, infusion and injection devices for administering drugs; software controlled drug delivery medical devices for medicine dosage and for providing web-based medical information for physical and psychological examination and assessment of patients remotely and at a clinic; software controlled drug delivery medical devices for dosage management, and for use in medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patient remotely and at a clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceutical preparations for the treatment of hypoparathyroidism; pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting hypoparathyroidism, endocrine disorders and bone disorders.
(2) Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medical treatment, patient assistance and health insurance in the field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to hypoparathyroidism, growth disorders, endocrine disorders and bone disorders and the treatment of hypoparathyroidism, growth disorders, endocrine disorders, bone disorders for use by patients with growth hormone disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their authorization and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay and other financial or medical access support; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders. dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic.
(3) Medical devices for injection, dosage and control of pharmaceuticals, namely, medical devices for injection, dosage measurement and monitoring of pharmaceuticals for the treatment of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely, syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism and skeletal dysplasia; medical apparatus, namely, infusion and injection devices for administering drugs; software controlled drug delivery medical devices for medicine dosage and for providing web-based medical information for physical and psychological examination and assessment of patients remotely and at a clinic; software controlled drug delivery medical devices for dosage management, and for use in medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patient remotely and at a clinic.
09 - Scientific and electric apparatus and instruments
Goods & Services
Downloadable application software for computers, mobile
phones, tablets, handheld computers and PCs, namely a
downloadable software application for use in providing
medical advice and advice on medical treatment, patient care
and health insurance; downloadable application software for
computers, mobile phones, tablets, handheld computers and
PCs, namely a downloadable software application o for
sharing information about physical and mental disorders for
use by patients and healthcare professionals; downloadable
application software for computers, mobile phones, tablets,
handheld computers and PCs, namely a downloadable software
application that coordinates the delivery of healthcare
between healthcare providers, patients and the parties
responsible for payment of healthcare, namely downloadable
software, which allows individuals seeking medical
education, information and services to locate a doctor and
clinic for medical treatment in their geographical area, and
allows physicians and healthcare professionals to
communicate information about their authorization and area
of expertise to patients and parties responsible for payment
of health services; downloadable application software for
computers, mobile phones, tablets, handheld computers and
PCs, namely a downloadable software application that enables
healthcare providers to monitor patients, disseminate
clinical information relevant to patient care, provide and
exchange patient information and health services provided to
patients; downloadable application software for computers,
mobile phones, tablets, handheld computers and PCs, namely a
downloadable software application for use in co-pay and
other financial or medical access support; downloadable
application software for computers, mobile phones, tablets,
handheld computers and PCs, namely a downloadable software
application for use in a communication platform that enables
users to share health and healthcare information;
downloadable application software for computers, mobile
phones, tablets, handheld computers and PCs, namely a
downloadable software application for measuring height,
weight, blood pressure, serum calcium, blood sugar and heart
rate; downloadable application software for computers,
mobile phones, tablets, handheld computers and PCs, namely a
downloadable software application for the use of delivery,
exchange, retrieval and analysis of health and healthcare
information; downloadable application software for
computers, mobile phones, tablets, handheld computers and
PCs, namely a downloadable software application for medical
purposes, namely for formatting, displaying and transmitting
medical data collected and stored on hormone injection pens
and pumps between injection pens and pumps and portable
electronic devices; downloadable application software for
computers, mobile phones, tablets, handheld computers and
PCs, namely a downloadable software application for
providing healthcare related information, medication
reminders and for tracking medical dosing history.
13.
LONG-ACTING GROWTH HORMONE DOSAGE FORMS WITH SUPERIOR EFFICACY TO DAILY SOMATROPIN
The present invention relates to a long-acting growth hormone or a pharmaceutical formulation comprising such long-acting growth hormone for use in a method of treating growth hormone deficiency with improved outcomes.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of hypoparathyroidism; pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting hypoparathyroidism, endocrine disorders and bone disorders Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to hypoparathyroidism, growth disorders, endocrine disorders and bone disorders and the treatment of hypoparathyroidism, growth disorders, endocrine disorders, bone disorders for use by patients with growth hormone disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay and other financial or medical access support; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders Medical devices for injection, dosage and control of pharmaceuticals, namely, medical devices for injection, dosage measurement and monitoring of pharmaceuticals for the treatment of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely, syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism and skeletal dysplasia; medical apparatus, namely, infusion and injection devices for administering drugs; medical apparatus for diagnostic purposes, namely, medicine dosage dispensers with integrated recorded software featuring web-based medical information collected via said apparatus for physical and psychological examination and assessment of patients remotely and at a clinic, sold as a unit; dosage management dispensers with integrated recorded software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic, namely, pen-type syringes and injection devices for administering drugs, sold as a unit
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for the treatment of hypoparathyroidism; pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting hypoparathyroidism, endocrine disorders and bone disorders
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of hypoparathyroidism; pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting hypoparathyroidism, endocrine disorders and bone disorders Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to hypoparathyroidism, growth disorders, endocrine disorders and bone disorders and the treatment of hypoparathyroidism, growth disorders, endocrine disorders, bone disorders for use by patients with growth hormone disorders, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay and other financial or medical access support; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders Medical devices for injection, dosage and control of pharmaceuticals, namely, medical devices for injection, dosage measurement and monitoring of pharmaceuticals for the treatment of hypoparathyroidism, growth disorders, endocrine disorders and bone disorders; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely, syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism and skeletal dysplasia; medical apparatus, namely, infusion and injection devices for administering drugs; medical apparatus for diagnostic purposes, namely, medicine dosage dispensers with integrated recorded software featuring web-based medical information collected via said apparatus for physical and psychological examination and assessment of patients remotely and at a clinic, sold as a unit; dosage management dispensers with integrated recorded software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic, namely, pen-type syringes and injection devices for administering drugs, sold as a unit
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of hypoparathyroidism; Pharmaceutical preparations for the treatment of disorders relating to growth, pharmaceutical preparations for the treatment of endocrinological disorders, pharmaceutical preparations for the treatment of skeletal disorders; Diagnostic preparations for medical use, namely, diagnostic preparations for the identification and detection of hypoparathyroidism, endocrinological disorders and skeletal disorders. Computer software and computer programs for use in providing medical advice and advice on medical treatment, patient care and health insurance within hypoparathyroidism, disorders relating to growth, endocrinological disorders and skeletal disorders; computer applicationsoftware, for use in relation to the following goods, Mobile telephones, Tablet computers, Palmtop computers, Personal computers, namely Downloadable application software for sharing information for use in the following fields: Disorders relating to hypoparathyroidism growth, endocrinological disorders and bone disorders and treatment of hypoparathyroidism, disorders relating to growth, endocrinological disorders and bone disorders for use by patients with disorders relating to growth, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, disorders relating to growth, endocrinological disorders and bone disorders; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, computer software that coordinates the delivery of health services between healthcare providers, patients and the parties responsible for payment of health services, namely computer software enabling individuals seeking medical education, information and service, to locate a doctor and medical clinic in their geographical area, and allows physicians and healthcare professionals to communicate information about the authorisation thereof and area of expertise to patients and parties responsible for payment of health services; computer applicationsoftware, for use in relation to the following goods, Mobile telephones, Tablet computers, Palmtop computers, Personal computers, namely Software that enables healthcare providers to monitor patients, disseminate clinical information relevant to patient care, deliver and exchange information about patients and healthcare services provided to patients; Downloadable software, software applications and mobile applications for co-pay and other financial or medical access support; Downloadable computer software for use as a communication platform that make it possible for the users to share information about health and healthcare; Downloadable software, software applications and mobile applications for measuring height, weight, blood pressure, serum calcium, blood sugar and pulse; Downloadable software, software applications and mobile applications for the delivery, exchange, retrieval and analysis of health and healthcare information; Formatting, displaying and transmitting medical data collected and stored on hormone injection pens and pumps between injection pens and pumps and portable electronic devices; computer applicationsoftware, for use in relation to the following goods, Mobile telephones, Tablet computers, Palmtop computers, Personal computers, Downloadable software application for delivery of healthcare-related information, medication reminders and for tracking medical dose history; The aforesaid relating to pharmaceutical preparations for the treatment of hypoparathyroidism, disorders relating to growth, endocrine-disrupting disorders, endocrinological disorders, and skeletal disorders. The aforesaid relating to pharmaceutical preparations for the treatment of hypoparathyroidism, disorders relating to growth, endocrine-disrupting disorders, endocrinological disorders, and skeletal disorders; Syringes for medical purposes and for injections; Syringes for injection of medical and surgical preparations, syringes in the shape of pens for surgical use; Digitally connected medical devices for monitoring dosage of pharmaceutical preparations for use in the treatment of growth hormone disorders, hypoparathyroidism and skeletal dysplasia; Medical equipments, in particular, Infusion and injection devices for administering medicinal preparations; Devices and instruments for diagnostic purposes, namely dosing dispensers for medicines containing software for control of medical information in web-based physical and psychological examination and evaluation of patients remotely and in the clinic; Dosing dispensers containing software for control of medical information for control of medicines and for therapeutic use in web-based physical and psychological examination and evaluation of patients remotely and in the clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of hypoparathyroidism; Pharmaceutical preparations for the treatment of disorders relating to growth, pharmaceutical preparations for the treatment of endocrinological disorders, pharmaceutical preparations for the treatment of skeletal disorders; Diagnostic preparations for medical use, namely, diagnostic preparations for the identification and detection of hypoparathyroidism, endocrinological disorders and skeletal disorders. Computer software and computer programs for use in providing medical advice and advice on medical treatment, patient care and health insurance within hypoparathyroidism, disorders relating to growth, endocrinological disorders and skeletal disorders; computer applicationsoftware, in relation to the following goods, Mobile telephones, Tablet computers, Palmtop computers, Personal computers, namely, Downloadable application software for sharing information, for use in the following fields: Disorders relating to hypoparathyroidism growth, endocrinological disorders and bone disorders and treatment of hypoparathyroidism, disorders relating to growth, endocrinological disorders and bone disorders for use by patients with disorders relating to growth, hypoparathyroidism and skeletal dysplasia in the medical field of hypoparathyroidism, disorders relating to growth, endocrinological disorders and bone disorders; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, computer software that coordinates the delivery of health services between healthcare providers, patients and the parties responsible for payment of health services, namely computer software enabling individuals seeking medical education, information and service, to locate a doctor and medical clinic in their geographical area, and allows physicians and healthcare professionals to communicate information about the authorisation thereof and area of expertise to patients and parties responsible for payment of health services; computer applicationsoftware for use in relation to the following goods: Mobile telephones, Tablet computers, Palmtop computers and Personal computers, namely Software that enables healthcare providers to monitor patients, disseminate clinical information relevant to patient care, deliver and exchange information about patients and healthcare services provided to patients; Downloadable software, software applications and mobile applications for co-pay and other financial or medical access support; Downloadable computer software for use as a communication platform that make it possible for the users to share information about health and healthcare; Downloadable software, software applications and mobile applications for measuring height, weight, blood pressure, serum calcium, blood sugar and pulse; Downloadable software, software applications and mobile applications for the delivery, exchange, retrieval and analysis of health and healthcare information; Formatting, displaying and transmitting medical data collected and stored on hormone injection pens and pumps between injection pens and pumps and portable electronic devices; computer applicationsoftware for use in relation to the following goods: Mobile telephones, Tablet computers, handheld computers and personal computers, Downloadable software application for delivery of healthcare-related information, medication reminders and for tracking medical dose history; The aforesaid relating to pharmaceutical preparations for the treatment of hypoparathyroidism, disorders relating to growth, endocrine-disrupting disorders, endocrinological disorders, and skeletal disorders. The aforesaid relating to pharmaceutical preparations for the treatment of hypoparathyroidism, disorders relating to growth, endocrine-disrupting disorders, endocrinological disorders, and skeletal disorders; Syringes for medical purposes and for injections; Syringes for injection of medical and surgical preparations, syringes in the shape of pens for surgical use; Digitally connected medical devices for monitoring dosage of pharmaceutical preparations for use in the treatment of growth hormone disorders, hypoparathyroidism and skeletal dysplasia; Medical equipments, in particular, Infusion and injection devices for administering medicinal preparations; Devices and instruments for diagnostic purposes, namely dosing dispensers for medicines containing software for control of medical information in web-based physical and psychological examination and evaluation of patients remotely and in the clinic; Dosing dispensers containing software for control of medical information for control of medicines and for therapeutic use in web-based physical and psychological examination and evaluation of patients remotely and in the clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of hypoparathyroidism; Pharmaceutical preparations for the treatment of disorders relating to growth, pharmaceutical preparations for the treatment of endocrinological disorders, pharmaceutical preparations for the treatment of skeletal disorders; Diagnostic preparations for medical use, namely, diagnostic preparations for the identification and detection of hypoparathyroidism, endocrinological disorders and skeletal disorders. Computer software and computer programs for use in providing medical advice and advice on medical treatment, patient care and health insurance within hypoparathyroidism, disorders relating to growth, endocrinological disorders and skeletal disorders; Computer application software formobile phones, Computer application software for tablet computers, Computer application software for handheld computers, Computer application software for personal computers, namely a downloadable application software for sharing information relating to disorders relating to hypoparathyroidism growth, endocrinological disorders and bone disorders and treatment of hypoparathyroidism, disorders relating to growth, endocrinological disorders and bone disorders for use by patients with disorders relating to growth, hypoparathyroidism and skeletal dysplasia in the medical; Field of hypoparathyroidism, disorders relating to growth, endocrinological disorders and bone disorders; Computer application software formobile phones, Computer application software for tablet computers, Computer application software for handheld computers, Computer application software for personal computer, namely Software that coordinates the providing of healthcare between healthcare providers, patients and the parties responsible for payment of healthcare, namely software that allows individuals seeking medical education, information and services to locate a physician and clinic for medical care in the geographic area thereof, and allows physicians and healthcare professionals to; Communicate information about their license and specialty area to patients and parties responsible for payment of healthcare; Computer application software formobile phones, Computer application software for tablet computers, Computer application software for personal computer and Computer application software for handheld computers, namely Software that enables healthcare providers to monitor patients, disseminate clinical information relevant to patient care, deliver and exchange information about patients and healthcare services provided to patients; Downloaded software, for use in the following fields: Co-pay and other financial or medical access support, Software applications and mobile applications for co-pay and other economical or medical access support; Downloadable computer software for use as a communication platform that make it possible for the users to share information about health and healthcare; Downloadable software, software applications and mobile applications for measuring height, weight, blood pressure, serum calcium, blood sugar and pulse; Downloaded software, for use in the following fields: Providing, exchange, retrieval and analysis of health and healthcare information, Software applications and mobile applications for delivery, sharing, collection and analysis of health and healthcare information; Formatting, displaying and transmitting medical data collected and stored on hormone injection pens and pumps between injection pens and pumps and portable electronic devices; Computer application software formobile phones, Computer application software for tablet computers, Computer application software for handheld computers, Computer application software for personal computer, Downloadable software application for delivery of healthcare-related information, medication reminders and for tracking medical dose history; The aforesaid relating to pharmaceutical preparations for the treatment of hypoparathyroidism, disorders relating to growth, endocrine-disrupting disorders, endocrinological disorders, and skeletal disorders. The aforesaid relating to pharmaceutical preparations for the treatment of hypoparathyroidism, disorders relating to growth, endocrine-disrupting disorders, endocrinological disorders, and skeletal disorders; Syringes for medical purposes and for injections; Syringes for injection of medical and surgical preparations, syringes in the shape of pens for surgical use; Digitally connected medical devices for monitoring dosage of pharmaceutical preparations for use in the treatment of growth hormone disorders, hypoparathyroidism and skeletal dysplasia; Medical equipments, in particular Infusion and injection devices for administering medicinal preparations; Devices and instruments for diagnostic purposes, namely dosing dispensers for medicines containing software for control of medical information in web-based physical and psychological examination and evaluation of patients remotely and in the clinic; Dosing dispensers containing software for control of medical information for control of medicines and for therapeutic use in web-based physical and psychological examination and evaluation of patients remotely and in the clinic.
09 - Scientific and electric apparatus and instruments
Goods & Services
downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for use in providing patient assistance; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to physical diseases for use by patients; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing a communications platform enabling users to share health and healthcare information; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored via injection pens and between said injection pens and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history
21.
PEGylated Recombinant Human Growth Hormone Compounds
A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
A61K 47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
C07K 14/61 - Growth hormone [GH], i.e. somatotropin
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment infectious diseases; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases. Computer software and computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable softwareapplication for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use; by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health; care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; Downloadable software, software applications and mobile applications for providing co-pay and other financial or medical access support; Downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, software applications and mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; Downloadable software, software applications and mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; Software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable softwareapplication for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for; use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of pharmaceuticals, namely medical devices for injection, dosage and control of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Syringes for medical purposes and for injections; Syringes for injection for medical and surgical use, namely syringes in the form of pens for surgical use; Digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; Medical apparatus, namely, infusion and injection devices for administering drugs; Apparatus and instruments for diagnostic purposes, namely, dosage management dispensers for medicines containing software for medical information management for use in web-based physical and psychological examination and assessment of patients remotely and at a clinic; Dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment infectious diseases; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases. Computer software and computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable softwareapplication for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; Downloadable software, software applications and mobile applications for providing co-pay and other financial or medical access support; Downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, software applications and mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; Downloadable oftware, software applications and mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; Software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable softwareapplication for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for; use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of pharmaceuticals, namely medical devices for injection, dosage and control of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Syringes for medical purposes and for injections; Syringes for injection for medical and surgical use, namely syringes in the form of pens for surgical use; Digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; Medical apparatus, namely, infusion and injection devices for administering drugs; Apparatus and instruments for diagnostic purposes, namely, dosage management dispensers for medicines containing software for medical information management for use in web-based physical and psychological examination and assessment of patients remotely and at a clinic; Dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth
disorders, pharmaceutical preparations for the treatment of
endocrine disorders, pharmaceutical preparations for the
treatment of bone disorders, pharmaceutical preparations for
the treatment of cancer, pharmaceutical preparations for the
treatment infectious diseases; diagnostic preparations for
medical use, namely, diagnostic preparations for identifying
and detecting growth hormone deficiency, endocrine
disorders, bone disorders, cancer, and infectious diseases. Computer software and computer programs for use in providing
medical advice and advice on medications for treatment,
patient assistance and health insurance in the field of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely a downloadable
software application for sharing information related to
growth disorders, endocrine disorders, bone disorders,
cancer, infectious diseases and the treatment of growth
disorders, endocrine disorders, bone disorders, cancer, and
infectious diseases for use by patients with growth hormone
disorders, hypoparathyroidism, skeletal dysplasia, and
diabetes in the medical field of growth disorders, endocrine
disorders, bone disorders, cancer, and infectious diseases;
computer application software for mobile phones, tablet
computers, handheld computers and personal computers,
namely, software that coordinates the delivery of health
care services between health care providers, patients and
those parties responsible for the payment of health care
services, namely software that allows individuals seeking
medical education, information and services to locate a
physician and treatment facility in their geographic area
for medical treatment and allows physicians and health care
professionals to communicate their credentials and
specialization to patients and parties responsible for
payment of healthcare services; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely, software that
enables health care providers to monitor patients,
communicate clinical information relevant to a patient's
care, provide and exchange information concerning patients
and the health care services provided to patients;
downloadable software, software applications and mobile
applications for providing co-pay and other financial or
medical access support; downloadable computer software for
providing a communications platform enabling users to share
health and healthcare information; downloadable software,
software applications and mobile applications for the
measurement of height, weight, blood pressure, serum
calcium, blood glucose, and heart rate; downloadable
software, software applications and mobile applications for
providing, exchanging, retrieving and analyzing health and
healthcare information; software for medical purposes,
namely, for formatting, viewing and transmitting medical
data collected and stored on hormone injection pens and
pumps and between said injection pens and pumps and portable
electronic devices; computer application software for mobile
phones, tablet computers, handheld computers and personal
computers, namely a downloadable software application for
providing healthcare-related information, medication
reminders, and tracking medication dosing history; the
foregoing related to pharmaceutical preparations for the
treatment of growth disorders, endocrine disorders, bone
disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of
pharmaceuticals, namely medical devices for injection,
dosage and control of pharmaceuticals for the treatment of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; syringes for medical
purposes and for injections; syringes for injection for
medical and surgical use, namely syringes in the form of
pens for surgical use; digitally connected medical devices
for monitoring the dispensation of pharmaceutical
preparations for use in connection with treatment of growth
hormone disorders, hypoparathyroidism, skeletal dysplasia,
cancer and diabetes; medical apparatus, namely, infusion and
injection devices for administering drugs; apparatus and
instruments for diagnostic purposes, namely, dosage
management dispensers for medicines, containing software for
medical information management for use in web-based physical
and psychological examination and assessment of patients
remotely and at a clinic; dosage management dispensers
containing software for medical information management for
guidance and control of medicines and for therapeutic use in
web-based physical and psychological examination and
assessment of patients remotely and at a clinic.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceutical preparations for the treatment of diseases, disorders and infections of the endocrine system, namely, growth and thyroid disorders, growth hormone deficiency, hypoparathyroidism, achondroplasia, diabetes, fibroblast growth factor receptor(FGFR)-related skeletal disorders, oncology, ophthalmology, infectious diseases and disorders namely, Intestinal infectious diseases, Infections with a predominantly sexual mode of transmission, Viral infections of the central nervous system, Arthropod-borne viral fevers and viral haemorrhagic fevers, Viral infections characterized by skin and mucous membrane lesions, Human immunodeficiency virus [HIV] disease, Mycoses, Protozoal diseases, Helminthiases, enzyme replacement therapy for the treatment of lysosomal storage diseases, anti-inflammatory disease, pain, namely, for the relief of pain and for the treatment of chronic pain, respiratory system disorder, autoimmune disorders, vaccines for human and veterinary use , non-alcoholic steatohepatitis, psychiatric and other brain diseases and disorders, namely, anxiety, mood disorders, schizophrenia, cognitive and bipolar disorders, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease, multiple sclerosis, bone diseases, CNS diseases, namely, encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease, myopathies, namely, muscular diseases caused by structural and functional abnormalities of skeletal muscle tissue, namely muscular dystrophies, congenital muscular dystrophies, congenital myopathies, distal myopathies, other myopathies namely, myofibrillar, incusion body, myotonic syndromes, ion channel muscle diseases, malignant hyoperthermias, metabolic myopathies, congenital myasthenic syndromes, sarcopenia, muscle atrophy and cachexia and metabolic diseases of muscle, metabolic myopathies, mintochondria myopathies namely, muscular dystrophy, mucopolysaccharideoses, and cancer, obesity, wound healing, the hormonal system, namely growth hormone deficiency, diabetes and angiogenesis, the ophthalmological system, namely angiogenesis, the angiogenic system, the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, the immune system, namely, immunologic diseases, namely, autoimmune diseases and immunologic deficiency syndromes, the cardio-vascular system, the metabolic system, namely, diabetes, hypoglycaemia, gout, osteoarthritis, muscular dystrophy, anemia, the respiratory system, the musculo-skeletal system, namely, growth hormone deficiency, connective tissue diseases, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries, the genitourinary system, namely, urological diseases, infertility, sexually transmitted diseases, inflammatory pelvic diseases; pharmaceutical preparations for the treatment of inflammatory disorders, namely, anti-inflammatories; diagnostic preparations for identification and proof of diseases, disorders and infections of the endocrine system, namely, growth and thyroid disorders, growth hormone deficiency, hypoparathyroidism, achondroplasia, diabetes, fibroblast growth factor receptor (FGFR)-related skeletal disorders, oncology, ophthalmology, infectious diseases and disorders namely, Intestinal infectious diseases, Infections with a predominantly sexual mode of transmission, Viral infections of the central nervous system, Arthropod-borne viral fevers and viral haemorrhagic fevers, Viral infections characterized by skin and mucous membrane lesions, Human immunodeficiency virus [HIV] disease, Mycoses, Protozoal diseases, Helminthiases, lysosomal storage diseases, anti-inflammatory disease, pain, respiratory system disorders, autoimmune disorders, non-alcoholic steatohepatitis, psychiatric and other brain diseases and disorders, namely, anxiety, mood disorders, schizophrenia, cognitive and bipolar disorders, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease, multiple sclerosis, bone diseases, CNS diseases, namely, encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease, myopathies, namely, muscular diseases caused by structural and functional abnormalities of skeletal muscle tissue, namely muscular dystrophies, congenital muscular dystrophies, congenital myopathies, distal myopathies, other myopathies namely, myofibrillar, incusion body, myotonic syndromes, ion channel muscle diseases, malignant hyoperthermias, metabolic myopathies, congenital myasthenic syndromes, sarcopenia, muscle atrophy and cachexia and metabolic diseases of muscle, metabolic myopathies, mintochondria myopathies namely, muscular dystrophy, mucopolysaccharideoses, and cancer, obesity, the hormonal system, namely growth hormone deficiency, diabetes and angiogenesis, the ophthalmological system, namely angiogenesis, the angiogenic system, the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, the immune system, namely, immunologic diseases, namely, autoimmune diseases and immunologic deficiency syndromes, the cardio-vascular system, the metabolic system, namely, diabetes, hypoglycaemia, gout, osteoarthritis, muscular dystrophy, anemia, the respiratory system, the musculo-skeletal system, namely, growth hormone deficiency, connective tissue diseases, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries, the genitourinary system, namely, urological diseases, infertility, sexually transmitted diseases, inflammatory pelvic diseases.
(2) Medical devices for injection, dosage and control of pharmaceutical preparations for the treatment of diseases, disorders and infections of the endocrine system, namely, growth and thyroid disorders, growth hormone deficiency, hypoparathyroidism, achondroplasia, diabetes, fibroblast growth factor receptor(FGFR)-related skeletal disorders, oncology, ophthalmology, infectious diseases and disorders namely, Intestinal infectious diseases, Infections with a predominantly sexual mode of transmission, Viral infections of the central nervous system, Arthropod-borne viral fevers and viral haemorrhagic fevers, Viral infections characterized by skin and mucous membrane lesions, Human immunodeficiency virus [HIV] disease, Mycoses, Protozoal diseases, Helminthiases, enzyme replacement therapy for the treatment of lysosomal storage diseases, anti-inflammatory disease, pain, namely, for the relief of pain and for the treatment of chronic pain, respiratory system disorder, autoimmune disorders, vaccines for human and veterinary use , non-alcoholic steatohepatitis, psychiatric and other brain diseases and disorders, namely, anxiety, mood disorders, schizophrenia, cognitive and bipolar disorders, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease, multiple sclerosis, bone diseases, CNS diseases, namely, encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease, myopathies, namely, muscular diseases caused by structural and functional abnormalities of skeletal muscle tissue, namely muscular dystrophies, congenital muscular dystrophies, congenital myopathies, distal myopathies, other myopathies namely, myofibrillar, incusion body, myotonic syndromes, ion channel muscle diseases, malignant hyoperthermias, metabolic myopathies, congenital myasthenic syndromes, sarcopenia, muscle atrophy and cachexia and metabolic diseases of muscle, metabolic myopathies, mintochondria myopathies namely, muscular dystrophy, mucopolysaccharideoses, and cancer, obesity, wound healing, the hormonal system, namely growth hormone deficiency, diabetes and angiogenesis, the ophthalmological system, namely angiogenesis, the angiogenic system, the central nervous system, namely, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, the immune system, namely, immunologic diseases, namely, autoimmune diseases and immunologic deficiency syndromes, the cardio-vascular system, the metabolic system, namely, diabetes, hypoglycaemia, gout, osteoarthritis, muscular dystrophy, anemia, the respiratory system, the musculo-skeletal system, namely, growth hormone deficiency, connective tissue diseases, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries, the genitourinary system, namely, urological diseases, infertility, sexually transmitted diseases, inflammatory pelvic diseases; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with treatment of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; medical infusion and injection devices for administering drugs; apparatus and instruments for diagnostic purposes, namely, dosage management dispensers for medicines, containing software for medical information management for use in web-based physical and psychological examination and assessment of patients remotely and at a clinic; dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic.
The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulation comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
C08G 65/334 - Polymers modified by chemical after-treatment with organic compounds containing sulfur
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth
disorders, pharmaceutical preparations for the treatment of
endocrine disorders, pharmaceutical preparations for the
treatment of bone disorders; diagnostic preparations for
medical use, namely, diagnostic preparations for identifying
and detecting growth hormone deficiency, endocrine
disorders, bone disorders, cancer and infectious diseases. Computer software and computer programs for use in providing
medical advice and advice on medications for treatment,
patient assistance and health insurance in the field of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely a downloadable
software application for sharing information related to
growth disorders, endocrine disorders, bone disorders,
cancer, infectious diseases and the treatment of growth
disorders, endocrine disorders, bone disorders, cancer, and
infectious diseases for use by patients with growth hormone
disorders, hypoparathyroidism, skeletal dysplasia, and
diabetes in the medical field of growth disorders, endocrine
disorders, bone disorders, cancer, and infectious diseases;
computer application software for mobile phones, tablet
computers, handheld computers and personal computers,
namely, software that coordinates the delivery of health
care services between health care providers, patients and
those parties responsible for the payment of health care
services, namely software that allows individuals seeking
medical education, information and services to locate a
physician and treatment facility in their geographic area
for medical treatment and allows physicians and health care
professionals to communicate their credentials and
specialization to patients and parties responsible for
payment of healthcare services; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely, software that
enables health care providers to monitor patients,
communicate clinical information relevant to a patient's
care, provide and exchange information concerning patients
and the health care services provided to patients;
downloadable software, software applications and mobile
applications for providing co-pay and other financial or
medical access support; downloadable computer software for
providing a communications platform enabling users to share
health and healthcare information; downloadable software,
software applications and mobile applications for the
measurement of height, weight, blood pressure, serum
calcium, blood glucose, and heart rate; downloadable
software, software applications and mobile applications for
providing, exchanging, retrieving and analyzing health and
healthcare information; software for medical purposes,
namely, for formatting, viewing and transmitting medical
data collected and stored on hormone injection pens and
pumps between injection pens and pumps and portable
electronic devices; computer application software for mobile
phones, tablet computers, handheld computers and personal
computers, namely a downloadable software application for
providing healthcare-related information, medication
reminders, and tracking medication dosing history'; the
foregoing related to pharmaceutical preparations for the
treatment of growth disorders, endocrine disorders, bone
disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of
pharmaceuticals, namely medical devices for injection,
dosage and control of pharmaceuticals for the treatment of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; syringes for medical
purposes and for injections; syringes for injection for
medical and surgical use, namely syringes in the form of
pens for surgical use; digitally connected medical devices
for monitoring the dosage of pharmaceutical preparations for
use in connection with management of growth hormone
disorders, hypoparathyroidism, skeletal dysplasia, cancer
and diabetes; medical apparatus, namely, infusion and
injection devices for administering drugs; medical apparatus
and instruments for diagnostic purposes namely dosage
management dispensers for medicines containing software for
medical information management for use in web-based physical
and psychological examination and assessment of patients
remotely and in a clinic; dosage management dispensers for
medicines incorporating software for medical information
management for guidance and control of medicines and for
therapeutic use in web-based physical and psychological
examination and assessment of patients remotely and at a
clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth
disorders, pharmaceutical preparations for the treatment of
endocrine disorders, pharmaceutical preparations for the
treatment of bone disorders; diagnostic preparations for
medical use, namely, diagnostic preparations for identifying
and detecting growth hormone deficiency, endocrine
disorders, bone disorders, cancer and infectious diseases. Computer software and computer programs for use in providing
medical advice and advice on medications for treatment,
patient assistance and health insurance in the field of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely a downloadable
software application for sharing information related to
growth disorders, endocrine disorders, bone disorders,
cancer, infectious diseases and the treatment of growth
disorders, endocrine disorders, bone disorders, cancer, and
infectious diseases for use by patients with growth hormone
disorders, hypoparathyroidism, skeletal dysplasia, and
diabetes in the medical field of growth disorders, endocrine
disorders, bone disorders, cancer, and infectious diseases;
computer application software for mobile phones, tablet
computers, handheld computers and personal computers,
namely, software that coordinates the delivery of health
care services between health care providers, patients and
those parties responsible for the payment of health care
services, namely software that allows individuals seeking
medical education, information and services to locate a
physician and treatment facility in their geographic area
for medical treatment and allows physicians and health care
professionals to communicate their credentials and
specialization to patients and parties responsible for
payment of healthcare services; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely, software that
enables health care providers to monitor patients,
communicate clinical information relevant to a patient's
care, provide and exchange information concerning patients
and the health care services provided to patients;
downloadable software, software applications and mobile
applications for providing co-pay and other financial or
medical access support; downloadable computer software for
providing a communications platform enabling users to share
health and healthcare information; downloadable software,
software applications and mobile applications for the
measurement of height, weight, blood pressure, serum
calcium, blood glucose, and heart rate; downloadable
software, software applications and mobile applications for
providing, exchanging, retrieving and analyzing health and
healthcare information; software for medical purposes,
namely, for formatting, viewing and transmitting medical
data collected and stored on hormone injection pens and
pumps between injection pens and pumps and portable
electronic devices; computer application software for mobile
phones, tablet computers, handheld computers and personal
computers, namely a downloadable software application for
providing healthcare-related information, medication
reminders, and tracking medication dosing history; the
foregoing related to pharmaceutical preparations for the
treatment of growth disorders, endocrine disorders, bone
disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of
pharmaceuticals, namely medical devices for injection,
dosage and control of pharmaceuticals for the treatment of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; syringes for medical
purposes and for injections; syringes for injection for
medical and surgical use, namely syringes in the form of
pens for surgical use; digitally connected medical devices
for monitoring the dosage of pharmaceutical preparations for
use in connection with management of growth hormone
disorders, hypoparathyroidism, skeletal dysplasia, cancer
and diabetes; medical apparatus, namely, infusion and
injection devices for administering drugs; medical apparatus
and instruments for diagnostic purposes namely dosage
management dispensers for medicines containing software for
medical information management for use in web-based physical
and psychological examination and assessment of patients
remotely and in a clinic; dosage management dispensers for
medicines incorporating software for medical information
management for guidance and control of medicines and for
therapeutic use in web-based physical and psychological
examination and assessment of patients remotely and at a
clinic.
29.
LONG-ACTING GROWTH HORMONE DOSAGE FORMS WITH SUPERIOR EFFICACY TO DAILY SOMATROPIN
The present invention relates to a long-acting growth hormone or a pharmaceutical formulation comprising such long-acting growth hormone for use in a method of treating growth hormone deficiency with improved outcomes.
A61K 9/19 - Particulate form, e.g. powders lyophilised
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61P 5/06 - Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
30.
LONG-ACTING GROWTH HORMONE DOSAGE FORMS WITH SUPERIOR EFFICACY TO DAILY SOMATROPIN
The present invention relates to a long-acting growth hormone or a pharmaceutical formulation comprising such long-acting growth hormone for use in a method of treating growth hormone deficiency with improved outcomes.
A61K 9/19 - Particulate form, e.g. powders lyophilised
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
A61P 5/06 - Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment infectious diseases; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay and other financial or medical access support; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases Medical devices for injection, dosage and control of pharmaceuticals, namely, medical devices for injection, dosage measurement and monitoring of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely, syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; medical apparatus, namely, infusion and injection devices for administering drugs; medical apparatus for diagnostic purposes, namely, medicine dosage dispensers containing software featuring web-based medical information for physical and psychological examination and assessment of patients remotely and at a clinic; dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment infectious diseases; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases. Computer software and computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable softwareapplication for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; Downloadable software, software applications and mobile applications for providing co-pay and other financial or medical access support; Downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, software applications and mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; Downloadable software, software applications and mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; Software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history the foregoing related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of pharmaceuticals, namely medical devices for injection, dosage and control of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Syringes for medical purposes and for injections; Syringes for injection for medical and surgical use, namely syringes in the form of pens for surgical use; Digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; Medical apparatus, namely, infusion and injection devices for administering drugs; Apparatus and instruments for diagnostic purposes, namely, dosage management dispensers for medicines containing software for medical information management for use in web-based physical and psychological examination and assessment of patients remotely and at a clinic; Dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic.
33.
Dry growth hormone composition transiently linked to a polymer carrier
The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such compositions are stable for at least 1 year, when stored at 2-8° C. The invention further relates to methods of manufacturing said compositions, containers comprising such composition as well as a kit of parts.
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment of infectious diseases; diagnostic preparations for medical purposes, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay and other financial or medical access support; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases Medical devices for injection, dosage and control of pharmaceuticals, namely, medical devices for injection, dosage measurement and monitoring of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely, syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; medical apparatus, namely, infusion and injection devices for administering drugs; medical apparatus for diagnostic purposes, namely, medicine dosage dispensers containing software featuring web-based medical information for physical and psychological examination and assessment of patients remotely and at a clinic; dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment of infectious diseases; diagnostic preparations for medical purposes, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay and other financial or medical access support; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases Medical devices for injection, dosage and control of pharmaceuticals, namely, medical devices for injection, dosage measurement and monitoring of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely, syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; medical apparatus, namely, infusion and injection devices for administering drugs; medical apparatus for diagnostic purposes, namely, medicine dosage dispensers containing software featuring web-based medical information for physical and psychological examination and assessment of patients remotely and at a clinic; dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth-related disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment of infectious diseases; Diagnostic preparations for medical use, namely diagnostic preparations for the identification and detection of growth hormone deficiency, endocrine disorders, bone disorders, cancer and infectious diseases. Computer software and computer programs for use in the providing of medical advice and advice about medical treatment, patient care and health insurance in the field of disorders relating to growth, endocrine disorders, bone disorders, cancer and infectious diseases; Computer application software for mobile telephones, tablets, handheld and personal computers, namely a downloadable software application for sharing information relating to growth-related disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth-related disorders, endocrine disorders, bone disorders, cancer, infectious diseases for use on patients with growth-related disorders, hypoparathyroidism, skeletal dysplasia and diabetes in the medical field of growth-related disorders, endocrinological disorders, bone disorders, cancer and infectious diseases; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, computer software that coordinates the delivery of health services between healthcare providers, patients and the parties responsible for payment of health services, namely computer software enabling individuals seeking medical education, information and service, to locate a doctor and medical clinic in their geographical area, and allows physicians and healthcare professionals to communicate information about the authorisation thereof and area of expertise to patients and parties responsible for payment of health services; Computer application software formobile phones, Tablet computers, handheld computers and personal computers, Namely software, That make it possible for healthcare providers to monitor patients, provide clinical information that is relevant for the care of the patient, deliver and share information about patients and healthcare services delivered to patients; Computer programs [downloadable software], Software applications and mobile applications for co-pay and other economical or medical access support; Downloadable computer software for use as a communication platform that make it possible for the users to share information about health and healthcare; Downloadable software, software applications and mobile applications for measuring height, weight, blood pressure, serum calcium, blood sugar and pulse; Computer programs [downloadable software], Software applications and mobile applications for delivery, sharing, collection and analysis of health and healthcare information; Formatting, displaying and transmitting medical data collected and stored on hormone injection pens and pumps between injection pens and pumps and portable electronic devices; Computer application software formobile phones, Tablet computers, handheld computers and personal computers, Downloadable software application for delivery of healthcare-related information, medication reminders and for tracking medical dose history; The aforesaid goods relating to pharmaceutical preparations for the treatment of disorders relating to growth, hormonal disorders, endocrine disorders, bone disorders, cancer and infectious diseases. Medical devices for the injection, dosage and control of drugs, in particular, medical devices for injection, dosage and control of drugs for the treatment of disorders relating to growth, hormonal disorders, endocrine disorders, bone disorders, cancer and infectious diseases; Syringes for medical purposes and for injections; Syringes for injection of medical and surgical preparations, syringes in the shape of pens for surgical use; Digitally-connected medical devices for monitoring the dosage of pharmaceutical preparations for use in the treatment of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; Medical apparatus, namely, infusion and injection devices for administering drugs; Devices and instruments for diagnostic purposes, namely dosing dispensers for medicines containing software for control of medical information in web-based physical and psychological examination and evaluation of patients remotely and in the clinic; Dosing dispensers containing software for control of medical information for control of medicines and for therapeutic use in web-based physical and psychological examination and evaluation of patients remotely and in the clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of disorders relating to growth, pharmaceutical preparations for the treatment of endocrinological disorders, pharmaceutical preparations for the treatment of skeletal disorders, Pharmaceutical preparation for the treatment of cancer, Pharmaceutical preparations for the treatment of infectious diseases; Diagnostic preparations for medicinal use, Namely, Diagnostic preparations for identification and proof of the lack of growth hormone, endocrinology diseases, bone diseases and cancer and infectious diseases. Computer software and computer programs for use in the providing of medical advice and advice about medical treatment, patient care and health insurance in the field of disorders relating to growth, endocrine disorders, bone disorders, cancer and infectious diseases; Computer application software formobile phones, Tablet computers, handheld computers and personal computers, In particular, downloadable application software for sharing information relating to disorders relating to growth, endocrine disorders, bone disorders, cancer, infectious diseases and treatment of disorders relating to growth, endocrine disorders, bone disorders, cancer, infectious diseases for use in patients with disorders relating to growth, hypoparathyroidism, skeletal dysplasia and diabetes in the medical field of disorders relating to growth, endocrine disorders, bone disorders, cancer and infectious diseases; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, computer software that coordinates the delivery of health services between healthcare providers, patients and the parties responsible for payment of health services, namely computer software enabling individuals seeking medical education, information and service, to locate a doctor and medical clinic in their geographical area, and allows physicians and healthcare professionals to communicate information about the authorisation thereof and area of expertise to patients and parties responsible for payment of health services; Computer application software formobile phones, Tablet computers, handheld computers and personal computers, Namely software, That make it possible for healthcare providers to monitor patients, provide clinical information that is relevant for the care of the patient, deliver and share information about patients and healthcare services delivered to patients; Computer programs [downloadable software], Software applications and mobile applications for co-pay and other economical or medical access support; Downloadable computer software for use as a communication platform that make it possible for the users to share information about health and healthcare; Downloadable software, software applications and mobile applications for measuring height, weight, blood pressure, serum calcium, blood sugar and pulse; Computer programs [downloadable software], Software applications and mobile applications for delivery, sharing, collection and analysis of health and healthcare information; Formatting, displaying and transmitting medical data collected and stored on hormone injection pens and pumps between injection pens and pumps and portable electronic devices; Computer application software formobile phones, Tablet computers, handheld computers and personal computers, Downloadable software application for delivery of healthcare-related information, medication reminders and for tracking medical dose history; The aforesaid goods relating to pharmaceutical preparations for the treatment of disorders relating to growth, hormonal disorders, endocrine disorders, bone disorders, cancer and infectious diseases. Medical devices for the injection, dosage and control of drugs, in particular, medical devices for injection, dosage and control of drugs for the treatment of disorders relating to growth, hormonal disorders, endocrine disorders, bone disorders, cancer and infectious diseases; Syringes for medical purposes and for injections; Syringes for injection of medical and surgical preparations, syringes in the shape of pens for surgical use; Digitally-connected medical devices for monitoring the dosage of pharmaceutical preparations for use in the treatment of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; Medical apparatus, namely, infusion and injection devices for administering drugs; Devices and instruments for diagnostic purposes, namely dosing dispensers for medicines containing software for control of medical information in web-based physical and psychological examination and evaluation of patients remotely and in the clinic; Dosing dispensers containing software for control of medical information for control of medicines and for therapeutic use in web-based physical and psychological examination and evaluation of patients remotely and in the clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth
disorders, pharmaceutical preparations for the treatment of
endocrine disorders, pharmaceutical preparations for the
treatment of bone disorders, pharmaceutical preparations for
the treatment of cancer, pharmaceutical preparations for the
treatment of infectious diseases; diagnostic preparations
for medical use, namely, diagnostic preparations for
identifying and detecting growth hormone deficiency,
endocrine disorders, bone disorders, cancer, and infectious
diseases. Computer software and computer programs for use in providing
medical advice and advice on medications for treatment,
patient assistance and health insurance in the field of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely a downloadable
software application for sharing information related to
growth disorders, endocrine disorders, bone disorders,
cancer, infectious diseases and the treatment of growth
disorders, endocrine disorders, bone disorders, cancer, and
infectious diseases for use by patients with growth hormone
disorders, hypoparathyroidism, skeletal dysplasia, and
diabetes in the medical field of growth disorders, endocrine
disorders, bone disorders, cancer, and infectious diseases;
computer application software for mobile phones, tablet
computers handheld computers and personal computers, namely,
software that coordinates the delivery of health care
services between health care providers, patients and those
parties responsible for the payment of health care services,
namely software that allows individuals seeking medical
education, information and services to locate a physician
and treatment facility in their geographic area for medical
treatment and allows physicians and health care
professionals to communicate their credentials and
specialization to patients and parties responsible for
payment of healthcare services; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely, software that
enables health care providers to monitor patients,
communicate clinical information relevant to a patient's
care, provide and exchange information concerning patients
and the health care services provided to patients;
downloadable software, software applications and mobile
applications for providing co-pay and other financial or
medical access support; downloadable computer software for
providing a communications platform enabling users to share
health and healthcare information; downloadable software,
software applications and mobile applications for the
measurement of height, weight, blood pressure, serum
calcium, blood glucose, and heart rate; downloadable
software, software applications and mobile applications for
providing, exchanging, retrieving and analyzing health and
healthcare information; software for medical purposes,
namely, for formatting, viewing and transmitting medical
data collected and stored on hormone injection pens and
pumps between injection pens and pumps and portable
electronic devices; computer application software for mobile
phones, tablet computers, handheld computers and personal
computers, namely a downloadable software application for
providing healthcare-related information, medication
reminders, and tracking medication dosing history; the
foregoing related to pharmaceutical preparations for the
treatment of growth disorders, endocrine disorders, bone
disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of
pharmaceuticals, namely medical devices for injection,
dosage and control of pharmaceuticals for the treatment of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; syringes for medical
purposes and for injections; syringes for injection for
medical and surgical use, namely syringes in the form of
pens for surgical use; digitally connected medical devices
for monitoring the dosage of pharmaceutical preparations for
use in connection with management of growth hormone
disorders, hypoparathyroidism, skeletal dysplasia, cancer
and diabetes; medical apparatus, namely, infusion and
injection devices for administering drugs; medical apparatus
and instruments for diagnostic purposes for use in dosage
management for medicines, containing software for medical
information management for use in web-based physical and
psychological examination and assessment of patients
remotely and in a clinic; medical apparatus for use in
dosage management of medicines, incorporating software for
medical information management for guidance and control of
medicines and for therapeutic use in web-based physical and
psychological examination and assessment of patients
remotely and at a clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth
disorders, pharmaceutical preparations for the treatment of
endocrine disorders, pharmaceutical preparations for the
treatment of bone disorders, pharmaceutical preparations for
the treatment of cancer, pharmaceutical preparations for the
treatment of infectious diseases; diagnostic preparations
for medical use, namely, diagnostic preparations for
identifying and detecting growth hormone deficiency,
endocrine disorders, bone disorders, cancer, and infectious
diseases. Computer software and computer programs for use in providing
medical advice and advice on medications for treatment,
patient assistance and health insurance in the field of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely a downloadable
software application for sharing information related to
growth disorders, endocrine disorders, bone disorders,
cancer, infectious diseases and the treatment of growth
disorders, endocrine disorders, bone disorders, cancer, and
infectious diseases for use by patients with growth hormone
disorders, hypoparathyroidism, skeletal dysplasia, and
diabetes in the medical field of growth disorders, endocrine
disorders, bone disorders, cancer, and infectious diseases;
computer application software for mobile phones, tablet
computers handheld computers and personal computers, namely,
software that coordinates the delivery of health care
services between health care providers, patients and those
parties responsible for the payment of health care services,
namely software that allows individuals seeking medical
education, information and services to locate a physician
and treatment facility in their geographic area for medical
treatment and allows physicians and health care
professionals to communicate their credentials and
specialization to patients and parties responsible for
payment of healthcare services; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely, software that
enables health care providers to monitor patients,
communicate clinical information relevant to a patient's
care, provide and exchange information concerning patients
and the health care services provided to patients;
downloadable software, software applications and mobile
applications for providing co-pay and other financial or
medical access support; downloadable computer software for
providing a communications platform enabling users to share
health and healthcare information; downloadable software,
software applications and mobile applications for the
measurement of height, weight, blood pressure, serum
calcium, blood glucose, and heart rate; downloadable
software, software applications and mobile applications for
providing, exchanging, retrieving and analyzing health and
healthcare information; software for medical purposes,
namely, for formatting, viewing and transmitting medical
data collected and stored on hormone injection pens and
pumps between injection pens and pumps and portable
electronic devices; computer application software for mobile
phones, tablet computers, handheld computers and personal
computers, namely a downloadable software application for
providing healthcare-related information, medication
reminders, and tracking medication dosing history; the
foregoing related to pharmaceutical preparations for the
treatment of growth disorders, endocrine disorders, bone
disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of
pharmaceuticals, namely medical devices for injection,
dosage and control of pharmaceuticals for the treatment of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; syringes for medical
purposes and for injections; syringes for injection for
medical and surgical use, namely syringes in the form of
pens for surgical use; digitally connected medical devices
for monitoring the dosage of pharmaceutical preparations for
use in connection with management of growth hormone
disorders, hypoparathyroidism, skeletal dysplasia, cancer
and diabetes; medical apparatus, namely, infusion and
injection devices for administering drugs; medical apparatus
and instruments for diagnostic purposes for use in dosage
management for medicines containing software for medical
information management for use in web-based physical and
psychological examination and assessment of patients
remotely and in a clinic; medical apparatus for use in
dosage management of medicines, incorporating software for
medical information management for guidance and control of
medicines and for therapeutic use in web-based physical and
psychological examination and assessment of patients
remotely and at a clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth
disorders, pharmaceutical preparations for the treatment of
endocrine disorders, pharmaceutical preparations for the
treatment of bone disorders, pharmaceutical preparations for
the treatment of cancer, pharmaceutical preparations for the
treatment of infectious diseases; diagnostic preparations
for medical use, namely, diagnostic preparations for
identifying and detecting growth hormone deficiency,
endocrine disorders, bone disorders, cancer, and infectious
diseases. Computer software and computer programs for use in providing
medical advice and advice on medications for treatment,
patient assistance and health insurance in the field of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely a downloadable
software application for sharing information related to
growth disorders, endocrine disorders, bone disorders,
cancer, infectious diseases and the treatment of growth
disorders, endocrine disorders, bone disorders, cancer, and
infectious diseases for use by patients with growth hormone
disorders, hypoparathyroidism, skeletal dysplasia, and
diabetes in the medical field of growth disorders, endocrine
disorders, bone disorders, cancer, and infectious diseases;
computer application software for mobile phones, tablet
computers handheld computers and personal computers, namely,
software that coordinates the delivery of health care
services between health care providers, patients and those
parties responsible for the payment of health care services,
namely software that allows individuals seeking medical
education, information and services to locate a physician
and treatment facility in their geographic area for medical
treatment and allows physicians and health care
professionals to communicate their credentials and
specialization to patients and parties responsible for
payment of healthcare services; computer application
software for mobile phones, tablet computers, handheld
computers and personal computers, namely, software that
enables health care providers to monitor patients,
communicate clinical information relevant to a patient's
care, provide and exchange information concerning patients
and the health care services provided to patients;
downloadable software, software applications and mobile
applications for providing co-pay and other financial or
medical access support; downloadable computer software for
providing a communications platform enabling users to share
health and healthcare information; downloadable software,
software applications and mobile applications for the
measurement of height, weight, blood pressure, serum
calcium, blood glucose, and heart rate; downloadable
software, software applications and mobile applications for
providing, exchanging, retrieving and analyzing health and
healthcare information; software for medical purposes,
namely, for formatting, viewing and transmitting medical
data collected and stored on hormone injection pens and
pumps between injection pens and pumps and portable
electronic devices; computer application software for mobile
phones, tablet computers, handheld computers and personal
computers, namely a downloadable software application for
providing healthcare-related information, medication
reminders, and tracking medication dosing history; the
foregoing related to pharmaceutical preparations for the
treatment of growth disorders, endocrine disorders, bone
disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of
pharmaceuticals, namely medical devices for injection,
dosage and control of pharmaceuticals for the treatment of
growth disorders, endocrine disorders, bone disorders,
cancer, and infectious diseases; syringes for medical
purposes and for injections; syringes for injection for
medical and surgical use, namely syringes in the form of
pens for surgical use; digitally connected medical devices
for monitoring the dosage of pharmaceutical preparations for
use in connection with management of growth hormone
disorders, hypoparathyroidism, skeletal dysplasia, cancer
and diabetes; medical apparatus, namely, infusion and
injection devices for administering drugs; medical apparatus
and instruments for diagnostic purposes for use in dosage
management for medicines containing software for medical
information management for use in web-based physical and
psychological examination and assessment of patients
remotely and in a clinic; medical apparatus for use in
dosage management of medicines incorporating software for
medical information management for guidance and control of
medicines and for therapeutic use in web-based physical and
psychological examination and assessment of patients
remotely and at a clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment infectious diseases; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases. Computer software and computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable softwareapplication for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; Downloadable software, software applications and mobile applications for providing co-pay and other financial or medical access support; Downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, software applications and mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; Downloadable software, software applications and mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; Software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of pharmaceuticals, namely medical devices for injection, dosage and control of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Syringes for medical purposes and for injections; Syringes for injection for medical and surgical use, namely syringes in the form of pens for surgical use; Digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; Medical apparatus, namely, infusion and injection devices for administering drugs; Apparatus and instruments for diagnostic purposes, namely, dosage management dispensers for medicines containing software for medical information management for use in web-based physical and psychological examination and assessment of patients remotely and at a clinic; Dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment infectious diseases; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay and other financial or medical access support; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases Medical devices for injection, dosage and control of pharmaceuticals, namely, medical devices for injection, dosage measurement and monitoring of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely, syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; medical apparatus, namely, infusion and injection devices for administering drugs; medical apparatus for diagnostic purposes, namely, medicine dosage dispensers containing software featuring web-based medical information for physical and psychological examination and assessment of patients remotely and at a clinic; dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic
43.
PEGylated recombinant human growth hormone compounds
A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
A61K 47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
C07K 14/61 - Growth hormone [GH], i.e. somatotropin
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment infectious diseases; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases. Computer software and computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable softwareapplication for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; Downloadable software, software applications and mobile applications for providing co-pay and other financial or medical access support; Downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, software applications and mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; Downloadable software, software applications and mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; Software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of pharmaceuticals, namely medical devices for injection, dosage and control of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Syringes for medical purposes and for injections; Syringes for injection for medical and surgical use, namely syringes in the form of pens for surgical use; Digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; Medical apparatus, namely, infusion and injection devices for administering drugs; Apparatus and instruments for diagnostic purposes, namely, dosage management dispensers for medicines containing software for medical information management for use in web-based physical and psychological examination and assessment of patients remotely and at a clinic; Dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases. Computer software and computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable softwareapplication for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; Downloadable software, software applications and mobile applications for providing co-pay and other financial or medical access support; Downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, software applications and mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; Downloadable software, software applications and mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; Software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of pharmaceuticals, namely medical devices for injection, dosage and control of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Syringes for medical purposes and for injections; Syringes for injection for medical and surgical use, namely syringes in the form of pens for surgical use; Digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; Medical apparatus, namely, infusion and injection devices for administering drugs; Apparatus and instruments for diagnostic purposes, namely, dosage management dispensers for medicines containing software for medical information management for use in web-based physical and psychological examination and assessment of patients remotely and at a clinic; Dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment infectious diseases; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases. Computer software and computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable softwareapplication for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; Downloadable software, software applications and mobile applications for providing co-pay and other financial or medical access support; Downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, software applications and mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; Downloadable software, software applications and mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; Software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; Computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases. Medical devices for injection, dosage and control of pharmaceuticals, namely medical devices for injection, dosage and control of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; Syringes for medical purposes and for injections; Syringes for injection for medical and surgical use, namely syringes in the form of pens for surgical use; Digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; Medical apparatus, namely, infusion and injection devices for administering drugs; Apparatus and instruments for diagnostic purposes, namely, dosage management dispensers for medicines containing software for medical information management for use in web-based physical and psychological examination and assessment of patients remotely and at a clinic; Dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay and other financial or medical access support; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases Medical devices for injection, dosage and control of pharmaceuticals, namely, medical devices for injection, dosage measurement and monitoring of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely, syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; medical apparatus, namely, infusion and injection devices for administering drugs; medical apparatus for diagnostic purposes, namely, medicine dosage dispensers containing software featuring web-based medical information for physical and psychological examination and assessment of patients remotely and at a clinic; dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment infectious diseases; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay and other financial or medical access support; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases Medical devices for injection, dosage and control of pharmaceuticals, namely, medical devices for injection, dosage measurement and monitoring of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely, syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; medical apparatus, namely, infusion and injection devices for administering drugs; medical apparatus for diagnostic purposes, namely, medicine dosage dispensers containing software featuring web-based medical information for physical and psychological examination and assessment of patients remotely and at a clinic; dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the treatment of growth disorders, pharmaceutical preparations for the treatment of endocrine disorders, pharmaceutical preparations for the treatment of bone disorders, pharmaceutical preparations for the treatment of cancer, pharmaceutical preparations for the treatment infectious diseases; diagnostic preparations for medical use, namely, diagnostic preparations for identifying and detecting growth hormone deficiency, endocrine disorders, bone disorders, cancer, and infectious diseases Downloadable computer software and downloadable computer programs for use in providing medical advice and advice on medications for treatment, patient assistance and health insurance in the field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for sharing information related to growth disorders, endocrine disorders, bone disorders, cancer, infectious diseases and the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases for use by patients with growth hormone disorders, hypoparathyroidism, skeletal dysplasia, and diabetes in the medical field of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; downloadable computer application software for mobile phones, tablet computers handheld computers and personal computers, namely, downloadable software that coordinates the delivery of health care services between health care providers, patients and those parties responsible for the payment of health care services, namely, downloadable software that allows individuals seeking medical education, information and services to locate a physician and treatment facility in their geographic area for medical treatment and allows physicians and health care professionals to communicate their credentials and specialization to patients and parties responsible for payment of healthcare services; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, downloadable software that enables health care providers to monitor patients, communicate clinical information relevant to a patient's care, provide and exchange information concerning patients and the health care services provided to patients; downloadable software, downloadable software applications and downloadable mobile applications for providing co-pay and other financial or medical access support; downloadable computer software for providing a communications platform enabling users to share health and healthcare information; downloadable software, downloadable software applications and downloadable mobile applications for the measurement of height, weight, blood pressure, serum calcium, blood glucose, and heart rate; downloadable software, downloadable software applications and downloadable mobile applications for providing, exchanging, retrieving and analyzing health and healthcare information; downloadable software for medical purposes, namely, for formatting, viewing and transmitting medical data collected and stored on hormone injection pens and pumps and between said injection pens and pumps and portable electronic devices; downloadable computer application software for mobile phones, tablet computers, handheld computers and personal computers, namely, a downloadable software application for providing healthcare-related information, medication reminders, and tracking medication dosing history; the foregoing downloadable software related to pharmaceutical preparations for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases Medical devices for injection, dosage and control of pharmaceuticals, namely, medical devices for injection, dosage measurement and monitoring of pharmaceuticals for the treatment of growth disorders, endocrine disorders, bone disorders, cancer, and infectious diseases; syringes for medical purposes and for injections; syringes for injection for medical and surgical use, namely, syringes in the form of pens for surgical use; digitally connected medical devices for monitoring the dispensation of pharmaceutical preparations for use in connection with management of growth hormone disorders, hypoparathyroidism, skeletal dysplasia, cancer and diabetes; medical apparatus, namely, infusion and injection devices for administering drugs; medical apparatus for diagnostic purposes, namely, medicine dosage dispensers containing software featuring web-based medical information for physical and psychological examination and assessment of patients remotely and at a clinic; dosage management dispensers containing software for medical information management for guidance and control of medicines and for therapeutic use in web-based physical and psychological examination and assessment of patients remotely and at a clinic
50.
Dry growth hormone composition transiently linked to a polymer carrier
The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such compositions are stable for at least 1 year, when stored at 2-8° C. The invention further relates to methods of manufacturing said compositions, containers comprising such composition as well as a kit of parts.
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 9/19 - Particulate form, e.g. powders lyophilised
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
C08G 65/334 - Polymers modified by chemical after-treatment with organic compounds containing sulfur
52.
Dry growth hormone composition transiently linked to a polymer carrier
The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such compositions are stable for at least 1 year, when stored at 2-8° C. The invention further relates to methods of manufacturing said compositions, containers comprising such composition as well as a kit of parts.
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
53.
PEGylated Recombinant Human Growth Hormone Compounds
A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
C07K 14/61 - Growth hormone [GH], i.e. somatotropin
A61K 47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61P 43/00 - Drugs for specific purposes, not provided for in groups
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
The present invention relates a pharmaceutical formulation comprising a long-acting growth hormone for use in a method of treating growth hormone deficiency, wherein the long-acting growth hormone formulation is administered to a patient in a bracketed dosage regimen, to a multitude of unit dosage forms comprising a long-acting growth hormone formulation, wherein the unit dosage forms comprise increasing amounts of growth hormone equivalents and wherein the amount of growth hormone equivalents increases by at least 10% between one unit dosage form and the next higher dosage form; their use in a method of treating growth hormone deficiency and method of treating growth hormone deficiency in a bracketed dosing regimen.
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
A61P 5/02 - Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
57.
Dry growth hormone composition transiently linked to a polymer carrier
The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such compositions are stable for at least 1 year, when stored at 2-8° C. The invention further relates to methods of manufacturing said compositions, containers comprising such composition as well as a kit of parts.
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
A61K 9/19 - Particulate form, e.g. powders lyophilised
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
58.
PEGylated recombinant human growth hormone compounds
A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.
A61K 38/27 - Growth hormone [GH], i.e. somatotropin
C07K 14/61 - Growth hormone [GH], i.e. somatotropin
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
59.
PEGYLATED RECOMBINANT HUMAN GROWTH HORMONE COMPOUNDS
A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61P 5/06 - Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
C07K 14/61 - Growth hormone [GH], i.e. somatotropin
