Inventage Lab, Inc.

Republic of Korea

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IPC Class
A61K 9/16 - AgglomeratesGranulatesMicrobeadlets 48
A61K 9/00 - Medicinal preparations characterised by special physical form 29
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin 13
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07 - Machines and machine tools 3
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1.

MICROPARTICLES COMPRISING SEMAGLUTIDE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PREPARATION METHOD THEREFOR

      
Application Number KR2024010766
Publication Number 2025/028903
Status In Force
Filing Date 2024-07-25
Publication Date 2025-02-06
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Min Sung

Abstract

The present invention relates to microparticles comprising semaglutide or a pharmaceutically acceptable salt thereof, and a preparation method therefor. When the microparticles are injected into the body as an injection, continuous release thereof for 4 weeks or more is possible without initial over-release of semaglutide or a pharmaceutically acceptable salt thereof. In addition, the present invention relates to a method for preparing microparticles having a donut shape in which a hole is formed in the center thereof at the cross-section of the microparticles, and having uniform diameters.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 38/26 - Glucagons

2.

COMPOSITION FOR SUSTAINED-RELEASE INJECTION COMPRISING DESLORELIN

      
Application Number 18767008
Status Pending
Filing Date 2024-07-09
First Publication Date 2024-10-31
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Min Sung

Abstract

A composition for sustained-release injection comprising deslorelin, can prevent initial over-release by adjusting the release rate of deslorelin at a target site and can exhibit the effect of deslorelin for 1 month or more by being exposed in an amount enough to show the effect of deslorelin. Further, the microparticles can prepare microparticles that have a uniform particle size and are capable of exhibiting the effect of continuously releasing deslorelin for a long time.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 38/09 - Luteinising hormone-releasing hormone [LHRH]Related peptides

3.

MICROPARTICLES CONTAINING CANNABIDIOL AND MANUFACTURING METHOD THEREFOR

      
Application Number KR2024095027
Publication Number 2024/155178
Status In Force
Filing Date 2024-01-17
Publication Date 2024-07-25
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Seo, Young Dai
  • Kim, Dong Gyu

Abstract

The present invention relates to microparticles containing cannabidiol, wherein the microparticles can possess improved stability by prevention of the oxidation of cannabidiol in the microparticles since the oxidation of cannabidiol contained in the microparticles causes a deterioration in the stability of the microparticles. The present invention also relates to a manufacturing method for microparticles with a uniform particle size, which contains cannabidiol and a biodegradable polymer, cannabidiol being uniformly contained in the microparticles.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 31/00 - Medicinal preparations containing organic active ingredients
  • A61K 9/50 - Microcapsules
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

4.

MICROPARTICLES CONTAINING MOXIDECTIN, AND PREPARATION METHOD THEREFOR

      
Application Number 18434686
Status Pending
Filing Date 2024-02-06
First Publication Date 2024-07-18
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention relates to microparticles comprising moxidectin and a biodegradable polymer, wherein the microparticles comprising moxidectin have a shape allowing a moxidectin drug to be uniformly distributed in spherical biodegradable polymer particles, and the average particle diameter of the microparticles is 45-130 μm, depending on the type of polymer. The present invention relates to: extended release microparticles capable of continuously maintaining a heartworm disease prevention effect for 3 months to 6 months by administering microparticles comprising moxidectin; and a preparation method therefor. In addition, the present invention is prepared such that the average diameters of the particles have a predetermined micrometer size, and thus reduces a foreign body sensation and pain during administration into an animal through injection, thereby enabling administration through injection to be facilitated.

IPC Classes  ?

5.

SPIRAL-STRUCTURED CHIP FOR PREPARING LIPID NANOPARTICLES, AND METHOD FOR PREPARING LIPID NANOPARTICLES BY USING SAME

      
Application Number KR2023016813
Publication Number 2024/147456
Status In Force
Filing Date 2023-10-27
Publication Date 2024-07-11
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Lee, Sang Hun
  • Seo, Hee Won
  • Chon, Chan Hee
  • Kim, Dong Hoon
  • Kim, Ju Hee

Abstract

The present invention relates to a spiral-structured chip for preparing lipid nanoparticles, and a method for preparing lipid nanoparticles by using same. The mixing efficiency of an aqueous solution that contains a nucleic acid and an oil solution that contains a lipid is increased such that uniform lipid nanoparticles can be formed by self-assembly at the interface between the aqueous solution and the oil solution. In addition, the provided preparation method can efficiently prepare lipid nanoparticles of a uniform shape and size by using the spiral-structured chip for preparing lipid nanoparticles.

IPC Classes  ?

  • B01F 33/30 - Micromixers
  • B01F 25/00 - Flow mixersMixers for falling materials, e.g. solid particles
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
  • B82Y 40/00 - Manufacture or treatment of nanostructures

6.

METHOD FOR PRODUCING SUSTAINED-RELEASE MICRO PARTICLES CONTAINING ATORVASTATIN AND SALT THEREOF, AND SUSTAINED-RELEASE MICRO PARTICLES PRODUCED THEREBY

      
Application Number KR2024000205
Publication Number 2024/147668
Status In Force
Filing Date 2024-01-04
Publication Date 2024-07-11
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Seo, Young Dai
  • Kim, Ju Hee

Abstract

The present invention relates to a method for producing sustained-release micro particles containing atorvastatin, and sustained-release micro particles produced thereby. The present invention relates to sustained-release micro particles that allow for increasing the encapsulation efficiency of atorvastatin and improving the removal of residual solvents and contains atorvastatin with uniform diameters. Additionally, the sustained-release micro particles containing atorvastatin produced by the aforementioned method can continuously release atorvastatin for one or two months with a single administration, thus improving dosing convenience.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
  • A61P 3/06 - Antihyperlipidemics

7.

LIPID NANOPARTICLES COMPRISING LOW-CONCENTRATION IONIZABLE LIPIDS, AND PREPARATION METHOD THEREFOR

      
Application Number KR2023020315
Publication Number 2024/136254
Status In Force
Filing Date 2023-12-11
Publication Date 2024-06-27
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Park, Hyo Chan
  • Chon, Chan Hee
  • Kim, Ju Hee

Abstract

The present invention relates to lipid nanoparticles comprising low-concentration ionizable lipids, and a preparation method therefor, and has a low amount of ionizable lipids in the lipid nanoparticles such that cytotoxicity can be reduced. In addition, according to the preparation method for lipid nanoparticles, of the present invention, the lipid nanoparticles have a uniform spherical shape and an excellent nucleic acid encapsulation rate, and, when lipid nanoparticles are prepared, amounts of non-ionized lipids and fusogenic lipids are increased such that a plurality of lipid nanoparticles can be prepared using an amount of nucleic acids which are the same as those used for conventional lipid nanoparticles, and, when the same nucleic acids are injected, the number of lipid nanoparticles to be injected into the body is increased such that the protein expression level of the nucleic acids can be increased.

IPC Classes  ?

  • A61K 9/51 - Nanocapsules
  • A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
  • A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
  • A61K 31/7088 - Compounds having three or more nucleosides or nucleotides

8.

SUSTAINED-RELEASE INJECTABLE COMPOSITION CONTAINING NALTREXONE AND METHOD FOR PREPARING SAME

      
Application Number 18285002
Status Pending
Filing Date 2022-11-18
First Publication Date 2024-06-20
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

A sustained-release injectable composition containing naltrexone, and a method for producing the same are described. The composition may prevent the initial burst release of naltrexone by controlling the release rate of naltrexone at a target site, and maintain a plasma naltrexone concentration sufficient to exhibit the effect of naltrexone by releasing naltrexone continuously for one month. In addition, the production method is capable of producing microparticles that are homogeneous and of good quality while having high encapsulation efficiency for naltrexone, a poorly soluble drug.

IPC Classes  ?

  • A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/19 - Particulate form, e.g. powders lyophilised
  • A61K 9/50 - Microcapsules

9.

EMULSION COMPRISING DEXAMETHASONE, PREPARATION METHOD THEREFOR, AND MICROPARTICLES COMPRISING DEXAMETHASONE

      
Application Number KR2023009296
Publication Number 2024/122778
Status In Force
Filing Date 2023-07-03
Publication Date 2024-06-13
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Sangno

Abstract

The present invention relates to an emulsion comprising dexamethasone, a preparation method therefor, and microparticles comprising dexamethasone, the emulsion and microparticles having a regular surface and a perfect spherical shape, and having dexamethasone evenly distributed. In addition, when administered in the body, there is no initial excessive release, and dexamethasone can be continuously released for a long time.

IPC Classes  ?

  • A61K 9/107 - Emulsions
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
  • A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

10.

METHOD FOR REMOVING ORGANIC SOLVENT REMAINING IN MICROPARTICLES BY USING COMPLEX AQUEOUS-PHASE SOLUTION

      
Application Number KR2023019543
Publication Number 2024/122991
Status In Force
Filing Date 2023-11-30
Publication Date 2024-06-13
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Sang No

Abstract

The present invention relates to a method for removing an organic solvent remaining in microparticles by using a complex aqueous-phase solution. The stirring time in a manufacturing process for the mass production of microparticles containing drugs and a process for removing an residual organic solvent can be shortened, the organic solvent can be efficiently removed, and the generation of related substances can be prevented.

IPC Classes  ?

  • A61K 9/14 - Particulate form, e.g. powders
  • B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
  • C08J 3/12 - Powdering or granulating

11.

METHOD FOR PREPARING MICROPARTICLES CONTAINING POORLY SOLUBLE DRUGS

      
Application Number 18284981
Status Pending
Filing Date 2022-11-17
First Publication Date 2024-06-06
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

A method for producing microparticles containing a poorly soluble drug, and microparticles produced by the method are proposed. According to the method for preparing microparticles, it is possible to produce microparticles that are uniform and of good quality and have high encapsulation efficiency for the poorly soluble drug and low contents of residual organic solvents, by using at least two organic solvents.

IPC Classes  ?

  • A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 31/445 - Non-condensed piperidines, e.g. piperocaine

12.

LIPID NANOPARTICLE PREPARATION METHOD AND PREPARATION APPARATUS THEREFOR

      
Application Number 18281915
Status Pending
Filing Date 2022-04-22
First Publication Date 2024-05-23
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Park, Hyochan
  • Chon, Chan Hee
  • Kim, Donghoon
  • Kim, Ju Hee

Abstract

The present disclosure relates to a method for manufacturing lipid nanoparticles and an apparatus for manufacturing the same, which are capable of increasing a production yield in a subsequent eradication filtration process and the like by not requiring a separate process for sorting the manufactured lipid nanoparticles. The present disclosure relates to a method for manufacturing lipid nanoparticles and an apparatus for manufacturing the same, which are capable of increasing a production yield in a subsequent eradication filtration process and the like by not requiring a separate process for sorting the manufactured lipid nanoparticles. In addition, by deviating from an existing optimal drug and lipid ratio, a content of ionizable lipid that causes a problem of toxicity when injected into the body may be lowered, and uniform-sized lipid nanoparticles may be manufactured.

IPC Classes  ?

  • A61K 9/51 - Nanocapsules
  • B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
  • B82Y 40/00 - Manufacture or treatment of nanostructures
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

13.

HANDYGENE

      
Application Number 232570800
Status Pending
Filing Date 2024-05-07
Owner INVENTAGE LAB INC. (Republic of Korea)
NICE Classes  ?
  • 07 - Machines and machine tools
  • 09 - Scientific and electric apparatus and instruments

Goods & Services

(1) Agitators for chemical processing; calcining machines for chemical processing; Separating machines for chemical processing; Blending machines for chemical processing; Dissolving machines for chemical processing; disintegrators for chemical processing; emulsifying machines for chemical processing; extracting machines for chemical processing; kneading machines for chemical processing; presses for chemical processing; sintering machines for chemical processing; sorting machines for chemical processing; grinding machines for chemical processing; Machines for manufacturing drug delivery systems, namely, sustained-release injectables and lipid-based nanoparticles; Industrial mixer for mixing liquids in the pharmaceutical and chemical industries; Filtering machines for chemical processing (2) Laboratory chemical reactors; liquid dispensing machines for dispensing pre-measured amounts; Chemical reaction apparatus, namely, reaction vessels and reservoir vessels; Gas mixers for laboratory use; laboratory photochemical reactors; Laboratory scales and balances; Laboratory filters, namely, syringe filters, disc members, vacuum filters; Apparatus for synthesizing protein and peptide; Laboratory chemical reactors; Bioreactors for laboratory use; bioreactors for cell culturing

14.

HANDYGENE

      
Application Number 019023716
Status Registered
Filing Date 2024-05-07
Registration Date 2024-09-20
Owner Inventage Lab Inc. (Republic of Korea)
NICE Classes  ?
  • 07 - Machines and machine tools
  • 09 - Scientific and electric apparatus and instruments

Goods & Services

agitators for chemical processing; separating machines for chemical processing; blending machines for chemical processing; chemical machines for industrial purposes; machines for drug delivery system manufacturing; handling machines, automatic, for pharmaceutical processing; agitators; electromechanical machines for chemical industry; filtering machines for chemical processing. chemical reactors; reaction vessels for chemical processing; apparatus and instruments for physics; chemistry apparatus and instruments; laboratory mixers; pharmaceutical chemical reactors; apparatus and instruments for weighing; laboratory filters; apparatus for synthesizing protein and peptide; laboratory apparatus for controlling process; bioreactors for research use.

15.

HANDYGENE

      
Serial Number 98533406
Status Pending
Filing Date 2024-05-03
Owner Inventage Lab Inc. (Republic of Korea)
NICE Classes  ?
  • 07 - Machines and machine tools
  • 09 - Scientific and electric apparatus and instruments

Goods & Services

Agitators for chemical processing; reaction vessels for chemical processing, namely, industrial chemical reactors; separating machines for chemical processing; blending machines for chemical processing; chemical machines for industrial purposes, namely, filtering machines for chemical processing, chemical fiber drying machines, sorting machine for chemical processing, blending machines for chemical processing, calcining machines for chemical processing, agitators for chemical processing, extracting machines for chemical processing; electrospinning machines for manufacturing fiber-based medical devices and pharmaceutical products in the nature of artificial tissue scaffolds and matrices, artificial scaffolds and matrices for local drug delivery, artificial scaffolds and matrices for targeted drug delivery, and artificial extracellular matrices; machine used for process filtration in the pharmaceutical industry; agitators for circulating liquid media; electromechanical machines for chemical industry, namely, blending machines for chemical processing, chemical processing machines for extracting, sintering, emulsifying, calcining and granulating chemicals; filtering machines for chemical processing Laboratory chemical reactors; apparatus and instruments for physics, namely, gravity measuring instruments, voltmeters, altimeters, densimeters, concentration meters and actinometers; chemistry apparatus and instruments, namely, flasks for laboratory use, laboratory pipettes, laboratory filters; laboratory mixers, namely, homogenizers and powder mixers for laboratory use, liquid mixers for laboratory use; pharmaceutical chemical reactors, namely, laboratory chemical reactors; apparatus and instruments for weighing; laboratory filters; apparatus for synthesizing protein and peptide; laboratory apparatus for controlling process, namely, chemical processing device; bioreactors for research use

16.

SUSTAINED-RELEASE INJECTABLE COMPOSITION FOR TREATING OR PREVENTING INFLAMMATORY DISEASE, AND METHOD FOR PREPARING SAME

      
Application Number KR2023015992
Publication Number 2024/085581
Status In Force
Filing Date 2023-10-17
Publication Date 2024-04-25
Owner
  • INVENTAGE LAB INC. (Republic of Korea)
  • YUHAN CARE CO., LTD. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Seo, Young Dai
  • Kim, Dong Kyu
  • Kang, Jong Soo
  • Park, Hyun Je
  • Cha, Joo Young

Abstract

The present invention relates to a sustained-release injectable composition for treating or preventing an inflammatory disease, and to a method for preparing same. The present invention may continuously release cannabidiol for more than one month by using microparticles containing cannabidiol, thereby having the effect of treating or preventing an inflammatory disease. In addition, the present invention provides the sustained-release injectable composition comprising cannabidiol which is non-toxic and can be used continuously for a long time as there are no side effects from long-term use, and thus may provide, by using a single injection, the effect of treating or preventing an inflammatory disease for more than one month, thereby greatly improving the convenience of administration.

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/05 - Phenols
  • A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

17.

SUSTAINED-RELEASE INJECTABLE COMPOSITION CONTAINING DUTASTERIDE

      
Application Number KR2023010142
Publication Number 2024/019439
Status In Force
Filing Date 2023-07-14
Publication Date 2024-01-25
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Min Sung
  • Kim, Ju Hee

Abstract

The present invention relates to a sustained-release injectable composition containing dutasteride, which may exhibit a continuous dutasteride release effect for at least three months, even when the dose of dutasteride that is taken is equal to or less than the pre-existing AVODART® which is taken once a day, and thus may exhibit a continuous drug taking effect for a long time from one injection. In addition, the sustained-release injectable composition may exhibit a continuous therapeutic effect for benign prostatic hyperplasia, prostate cancer and hair loss for at least three months, and microparticles contained in the sustained-release injectable composition have a predetermined average diameter, and thus drug release may be controlled so that an effective drug concentration may be constantly maintained, and a foreign body sensation and pain may be reduced when the sustained-release injectable composition is administered as an injection to a patient.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

18.

MICROSPHERE PRODUCING SYSTEM AND MICROSPHERE PRODUCING METHOD

      
Application Number 18038535
Status Pending
Filing Date 2021-08-02
First Publication Date 2024-01-18
Owner Inventage Lab Inc. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Chon, Chan Hee

Abstract

A system for producing a microsphere includes a first raw material storing to store a first raw material is stored, a second raw material storing part to store a second raw material including a solvent, a biodegradable polymer, and a drug, an emulsion generating part to continuously form an emulsion including the first raw material of a continuous phase and the second raw material of a dispersed phase, a first solvent extracting and removing part to accommodate the emulsion formed from the emulsion generating part, and extract and remove the solvent from the dispersed phase of the emulsion to form a microsphere, and a second solvent extracting and removing part spaced apart from the first solvent extracting and removing part, to accommodate the emulsion formed from the emulsion generating part, and extract and remove the solvent from the dispersed phase of the emulsion to form a microsphere.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

19.

Solvent removing apparatus and method of producing microsphere using the same

      
Application Number 18038589
Grant Number 12083225
Status In Force
Filing Date 2021-12-03
First Publication Date 2023-11-02
Grant Date 2024-09-10
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Chon, Chan Hee

Abstract

A solvent-removing apparatus according to an embodiment includes a tank body accommodating an emulsion including first source material in a continuous phase and second source material in a dispersed phase, a fluid supply unit for supplying fluid into the tank body to cause the emulsion to circulate, and a discharge unit for discharging the gas in the tank body to the outside.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • B01D 17/04 - Breaking emulsions
  • B01D 35/027 - Filters adapted for location in special places, e.g. pipe-lines, pumps, stop-cocks rigidly mounted in or on tanks or reservoirs

20.

METHOD FOR PREPARING MICROPARTICLES CONTAINING MOXIDECTIN AND SUSTAINED-RELEASE INJECTABLE COMPOSITION COMPRISING MICROPARTICLES PREPARED BY SAME PREPARATION METHOD

      
Application Number KR2022005969
Publication Number 2023/200036
Status In Force
Filing Date 2022-04-27
Publication Date 2023-10-19
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Sang No

Abstract

The present invention relates to microparticles containing moxidectin and a method for preparing same. Unlike conventional drugs for preventing heartworm disease, which have a short half-life and require daily or monthly administration, when the microparticles containing moxidectin are administered, moxidectin is continuously released for 3 months or longer, and thus, a heartworm disease preventive effect can be maintained. In addition, by preparing microparticles having a constant average particle diameter and a narrow diameter distribution width, even when the microparticles are administered, the initial over-release of moxidectin is prevented, and the release of the drug is controlled so that a concentration of moxidectin effective for three months or longer can be kept constant, and when the microparticles are applied as an injection, foreign body sensation and pain can be reduced.

IPC Classes  ?

21.

MICROPARTICLES CONTAINING MOXIDECTIN AND SUSTAINED-RELEASE INJECTION COMPOSITION CONTAINING SAME

      
Application Number KR2022005968
Publication Number 2023/200035
Status In Force
Filing Date 2022-04-27
Publication Date 2023-10-19
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Sang No

Abstract

The present invention relates to microparticles containing moxidectin, and a preparation method thereof. Unlike conventional heartworm prevention drugs that have a short half-life and thus require daily or monthly administration, moxidectin is continuously released for at least three months and thus the effect of preventing heartworms can be maintained for at least three months when the microparticles containing moxidectin are administered. In addition, microparticles which have a constant average diameter and a narrow diameter distribution are prepared so that initial over-release of moxidectin is prevented when the microparticles are administered, the release of the drug can be controlled to keep constant the concentration of moxidectin that is valid for at least three months, and foreign body sensation and pain can be reduced when the microparticles are applied in the form of an injection.

IPC Classes  ?

22.

SUSTAINED FORMULATION FOR PREVENTION OR TREATMENT OF AUTOIMMUNE DISEASE CONTAINING LOW-DOSE NALTREXONE AND METHOD USING THE SAME

      
Application Number 18325567
Status Pending
Filing Date 2023-05-30
First Publication Date 2023-09-28
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Mase
  • Kim, Donghoon

Abstract

The present disclosure provides a sustained formulation for prevention or treatment of autoimmune disease, comprising microparticles comprising naltrexone or pharmaceutically acceptable salts thereof, and biodegradable polymers, and a method using the same. Accordingly, it may be used to prevent or treat autoimmune diseases for a prolonged period of time with a single administration.

IPC Classes  ?

  • A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
  • A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
  • A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

23.

LIPID NANOPARTICLES MANUFACTURING CHIP, LIPID NANOPARTICLES MANUFACTURING SYSTEM HAVING THE SAME, AND LIPID NANOPARTICLES MANUFACTURING METHOD

      
Application Number 18024743
Status Pending
Filing Date 2022-05-11
First Publication Date 2023-09-14
Owner Inventage Lab Inc. (Republic of Korea)
Inventor
  • Han, Euidon
  • Chon, Chan Hee
  • Kim, Dong Hoon
  • Kim, Ju Hee

Abstract

A lipid nanoparticles manufacturing chip includes a mixer unit for forming a mixed solution by mixing a first raw material containing an active ingredient and a second raw material containing a lipid, a dilution unit that is connected to the mixer unit and dilutes the mixed solution using a diluent solution to make a diluted mixed solution, and a concentration unit connected to the dilution unit and for obtaining a concentrated solution by concentrating lipid nanoparticles (LNP) from the diluted mixed solution.

IPC Classes  ?

  • A61K 9/51 - Nanocapsules
  • B01F 33/301 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
  • B01F 23/41 - Emulsifying
  • B01F 23/451 - Mixing liquids with liquidsEmulsifying using flow mixing by injecting one liquid into another
  • B01F 23/40 - Mixing liquids with liquidsEmulsifying
  • B01F 23/80 - After-treatment of the mixture
  • C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

24.

SUSTAINED-RELEASE INJECTABLE COMPOSITION CONTAINING DESLORELIN

      
Application Number KR2023002240
Publication Number 2023/158228
Status In Force
Filing Date 2023-02-16
Publication Date 2023-08-24
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Min Sung

Abstract

The present invention relates to a sustained-release injectable composition containing deslorelin, wherein the release rate of deslorelin is controlled at a target site so that initial over-release is prevented and an amount sufficient for the effects of deslorelin to be exhibited is exposed, and thus the effect of the deslorelin can be exhibited for at least one month. Also, the microparticles can be prepared to have a uniform particle size and continuously exhibit a deslorelin releasing effect for a long period of time.

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/10 - DispersionsEmulsions
  • A61K 38/09 - Luteinising hormone-releasing hormone [LHRH]Related peptides
  • A61P 15/00 - Drugs for genital or sexual disordersContraceptives
  • A61P 15/16 - Masculine contraceptives

25.

COMPOSITION FOR SUSTAINED-RELEASE INJECTION COMPRISING DESLORELIN

      
Application Number 18170602
Status Pending
Filing Date 2023-02-17
First Publication Date 2023-08-24
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Min Sung

Abstract

A composition for sustained-release injection comprising deslorelin, can prevent initial over-release by adjusting the release rate of deslorelin at a target site and can exhibit the effect of deslorelin for 1 month or more by being exposed in an amount enough to show the effect of deslorelin. Further, the microparticles can prepare microparticles that have a uniform particle size and are capable of exhibiting the effect of continuously releasing deslorelin for a long time.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 38/09 - Luteinising hormone-releasing hormone [LHRH]Related peptides
  • A61K 9/00 - Medicinal preparations characterised by special physical form

26.

SOLVENT REMOVING APPARATUS AND METHOD OF MANUFACTURING MICROSPHERE USING SAME

      
Application Number KR2022019031
Publication Number 2023/146101
Status In Force
Filing Date 2022-11-29
Publication Date 2023-08-03
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Dong Hoon
  • Chon, Chan Hee
  • Kim, Ju Hee

Abstract

This solvent removing apparatus comprises: a container for receiving an emulsion including a first raw material of a continuous phase and a second raw material of a dispersed phase; a filter unit that is connected to the inside of the container, receives the emulsion from the container, filters out a portion of the continuous phase of the emulsion and a solvent in the continuous phase, and then provides the remaining emulsion back to the container; a supply unit that is connected to the inside of the container and supplies the first raw material into the container; and a stirring means that generates flow in the emulsion inside the container, thereby stirring the emulsion.

IPC Classes  ?

  • B01D 11/04 - Solvent extraction of solutions which are liquid
  • B01D 1/30 - Accessories for evaporators
  • B01D 35/02 - Filters adapted for location in special places, e.g. pipe-lines, pumps, stop-cocks
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

27.

Solvent removing apparatus and method of manufacturing microsphere using the same

      
Application Number 18083670
Grant Number 11944949
Status In Force
Filing Date 2022-12-19
First Publication Date 2023-06-22
Grant Date 2024-04-02
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Lee, Sanghun
  • Chon, Chan Hee
  • Kim, Ju Hee

Abstract

A solvent removing apparatus includes a container containing an emulsion comprising a first raw material of a continuous phase and a second raw material of a dispersed phase, an impeller rotating in the container to stir the emulsion, and a foam breaker spaced apart from the impeller on an upper portion of the impeller, positioned below a surface of the emulsion to be submerged in the emulsion when the emulsion is calm, and rotating to reduce foam generated during stirring of the emulsion.

IPC Classes  ?

  • B01J 13/12 - Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • B01D 17/02 - Separation of non-miscible liquids
  • B01D 17/04 - Breaking emulsions
  • B01D 19/02 - Foam dispersion or prevention
  • B01F 27/191 - Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
  • B01F 27/86 - Mixers with rotary stirring devices in fixed receptaclesKneaders with stirrers rotating about a substantially vertical axis co-operating with deflectors or baffles fixed to the receptacle
  • B01F 35/53 - Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus

28.

Microparticles containing leuprolide and method for producing the same

      
Application Number 17832229
Grant Number 12016897
Status In Force
Filing Date 2022-06-03
First Publication Date 2023-06-08
Grant Date 2024-06-25
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Min Sung

Abstract

The present invention provides microparticles containing leuprolide and a method for producing the same. When the microparticles are administered by injection, they may lower pain due to their small size, control the release rate of leuprolide at a target site, prevent excessive release of leuprolide at an initial stage, enable exposure to a sufficient amount of the drug to exhibit the effect of leuprolide, and exhibit the effect of leuprolide for 1 month or more. The present invention also provides a method for producing microparticles, in which the microparticles have a uniform particle size and a smooth surface and may exhibit the effect of releasing leuprolide sustainably over a long period of time.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 38/09 - Luteinising hormone-releasing hormone [LHRH]Related peptides

29.

MICROPARTICLES CONTAINING LEUPROLIDE, AND PREPARATION METHOD THEREOF

      
Application Number KR2022018982
Publication Number 2023/101348
Status In Force
Filing Date 2022-11-28
Publication Date 2023-06-08
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Min Sung

Abstract

The present invention relates to microparticles containing leuprolide and a preparation method thereof. When the microparticles are administered as an injection, the pain of the injection may be reduced due to the small size of the microparticles, the release rate of leuprolide is adjusted at a target site to prevent initial over-release, and the effects of leuprolide are exhibited, and thus the target site is exposed to a sufficient amount of the drug, and the effects of leuprolide may be exhibited for one month or longer. In addition, the present invention relates to a method for preparing the microparticles, wherein the microparticles have a uniform size and a smooth surface, and can continually exhibit the effects of leuprolide release for a long period of time.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 38/09 - Luteinising hormone-releasing hormone [LHRH]Related peptides

30.

METHOD FOR PREPARING MICROPARTICLES CONTAINING POORLY SOLUBLE DRUGS

      
Document Number 03236685
Status Pending
Filing Date 2022-11-17
Open to Public Date 2023-05-25
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention pertains to: a method for preparing microparticles containing poorly soluble drugs; and microparticles prepared by the method. The method for preparing microparticles uses two or more organic solvents and can thus be used to prepare microparticles having uniform and excellent quality, a high encapsulation rate of poorly soluble drugs, and a small amount of residual organic solvents.

IPC Classes  ?

  • A61K 9/50 - Microcapsules
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

31.

METHOD FOR PREPARING MICROPARTICLES CONTAINING POORLY SOLUBLE DRUGS

      
Application Number KR2022018216
Publication Number 2023/090899
Status In Force
Filing Date 2022-11-17
Publication Date 2023-05-25
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention pertains to: a method for preparing microparticles containing poorly soluble drugs; and microparticles prepared by the method. The method for preparing microparticles uses two or more organic solvents and can thus be used to prepare microparticles having uniform and excellent quality, a high encapsulation rate of poorly soluble drugs, and a small amount of residual organic solvents.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

32.

SUSTAINED-RELEASE INJECTABLE COMPOSITION CONTAINING NALTREXONE AND METHOD FOR PREPARING SAME

      
Document Number 03236690
Status Pending
Filing Date 2022-11-18
Open to Public Date 2023-05-25
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention relates to a sustained-release injectable composition containing naltrexone, and a method for preparing same, wherein the release rate of naltrexone is controlled at a target site to prevent initial over-release, and naltrexone is continuously released for one month, such that blood concentrations sufficient to exhibit effects caused by naltrexone can be maintained. In addition, the present invention relates to a manufacturing method enabling microparticles having a high encapsulation rate of naltrexone, which is a poorly soluble drug, to be produced while the microparticles are homogeneous and of excellent quality.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

33.

SUSTAINED-RELEASE INJECTABLE COMPOSITION CONTAINING NALTREXONE AND METHOD FOR PREPARING SAME

      
Application Number KR2022018258
Publication Number 2023/090922
Status In Force
Filing Date 2022-11-18
Publication Date 2023-05-25
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention relates to a sustained-release injectable composition containing naltrexone, and a method for preparing same, wherein the release rate of naltrexone is controlled at a target site to prevent initial over-release, and naltrexone is continuously released for one month, such that blood concentrations sufficient to exhibit effects caused by naltrexone can be maintained. In addition, the present invention relates to a manufacturing method enabling microparticles having a high encapsulation rate of naltrexone, which is a poorly soluble drug, to be produced while the microparticles are homogeneous and of excellent quality.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

34.

Microparticle producing system which comprises carrying fluid, and a controlling method thereof

      
Application Number 17759237
Grant Number 11731100
Status In Force
Filing Date 2021-01-27
First Publication Date 2023-03-09
Grant Date 2023-08-22
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Donghoon
  • Chon, Chan Hee

Abstract

A microparticle producing system using microfluidics and a controlling method thereof, and specifically, to a microparticle producing system that may stably transport droplets produced using microfluidics without agglomeration or destruction, compared to the conventional art, and a method of controlling the microparticle producing system to transport the droplets more stably in the microparticle producing system. By the microparticle producing system and the controlling method thereof, which are disclosed herein, droplets produced by the microparticle producing system using microfluidics may be stably transported without agglomeration or destruction, resulting in more effective microparticle production.

IPC Classes  ?

  • B01J 19/06 - Solidifying liquids
  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
  • A61K 9/00 - Medicinal preparations characterised by special physical form

35.

CHIP FOR PREPARING LIPID NANOPARTICLES, SYSTEM FOR PREPARING LIPID NANOPARTICLES COMPRISING SAME, AND METHOD FOR PREPARING LIPID NANOPARTICLES

      
Application Number KR2022010957
Publication Number 2023/008875
Status In Force
Filing Date 2022-07-26
Publication Date 2023-02-02
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Lee, Sanghun
  • Kim, Ju Hee
  • Kim, Dong Hoon
  • Chon, Chan Hee

Abstract

This chip for preparing lipid nanoparticles comprises: a first raw material supply channel; a second raw material supply channel; and a mixer that is connected to the first raw material supply channel and the second raw material supply channel and mixes a first raw material supplied through the first raw material supply channel and a second raw material supplied through the second raw material supply channel. The mixer includes a first stabilization part and a first mixing part which is connected to the first stabilization part and in which the first raw material is mixed with the second raw material. More of the mixing of the first raw material and the second raw material takes place in the first mixing part than in the first stabilizing part.

IPC Classes  ?

  • B01F 33/30 - Micromixers
  • B01F 33/3011 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
  • B01F 25/00 - Flow mixersMixers for falling materials, e.g. solid particles
  • B01F 23/80 - After-treatment of the mixture
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • B01F 101/22 - Mixing of ingredients for pharmaceutical or medical compositions
  • B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

36.

NANO LIPID PARTICLES MANUFACTURING CHIP, NANO LIPID PARTICLES MANUFACTURING SYSTEM HAVING THE SAME, AND NANO LIPID PARTICLES MANUFACTURING METHOD

      
Document Number 03227332
Status Pending
Filing Date 2022-07-26
Open to Public Date 2023-02-02
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Lee, Sanghun
  • Kim, Ju Hee
  • Kim, Dong Hoon
  • Chon, Chan Hee

Abstract

This chip for preparing lipid nanoparticles comprises: a first raw material supply channel; a second raw material supply channel; and a mixer that is connected to the first raw material supply channel and the second raw material supply channel and mixes a first raw material supplied through the first raw material supply channel and a second raw material supplied through the second raw material supply channel. The mixer includes a first stabilization part and a first mixing part which is connected to the first stabilization part and in which the first raw material is mixed with the second raw material. More of the mixing of the first raw material and the second raw material takes place in the first mixing part than in the first stabilizing part.

IPC Classes  ?

  • B01F 33/30 - Micromixers
  • B01F 23/80 - After-treatment of the mixture
  • B01F 25/00 - Flow mixersMixers for falling materials, e.g. solid particles
  • B01F 33/3011 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

37.

Sustained formulation for prevention or treatment of autoimmune disease containing naltrexone and method using the same

      
Application Number 17871428
Grant Number 11730731
Status In Force
Filing Date 2022-07-22
First Publication Date 2022-11-24
Grant Date 2023-08-22
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Mase
  • Kim, Donghoon

Abstract

The present disclosure provides a sustained formulation for prevention or treatment of autoimmune disease, comprising microparticles comprising naltrexone or pharmaceutically acceptable salts thereof, and biodegradable polymers, and a method using the same. Accordingly, it may be used to prevent or treat autoimmune diseases for a prolonged period of time with a single administration.

IPC Classes  ?

  • A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
  • A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
  • A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

38.

LIPID NANOPARTICLES MANUFACTURING CHIP, LIPID NANOPARTICLES MANUFACTURING SYSTEM HAVING THE SAME, AND LIPID NANOPARTICLES MANUFACTURING METHOD

      
Document Number 03194915
Status Pending
Filing Date 2022-05-11
Open to Public Date 2022-11-17
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Han, Euidon
  • Chon, Chan Hee
  • Kim, Dong Hoon
  • Kim, Ju Hee

Abstract

A lipid nanoparticles manufacturing chip comprises a mixer unit for forming a mixed solution by mixing a first raw material containing an active ingredient and a second raw material containing a lipid, a dilution unit that is connected to the mixer unit and dilutes the mixed solution using a diluent solution to make a diluted mixed solution, and a concentration unit connected to the dilution unit and for obtaining a concentrated solution by concentrating lipid nanoparticles (LNP) from the diluted mixed solution.

IPC Classes  ?

  • B01F 23/80 - After-treatment of the mixture
  • B01F 25/00 - Flow mixersMixers for falling materials, e.g. solid particles
  • B01F 33/30 - Micromixers
  • B01F 33/301 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

39.

CHIP FOR PREPARING LIPID NANOPARTICLES, SYSTEM FOR PREPARING LIPID NANOPARTICLES COMPRISING SAME, AND METHOD FOR PREPARING LIPID NANOPARTICLES

      
Application Number KR2022006749
Publication Number 2022/240193
Status In Force
Filing Date 2022-05-11
Publication Date 2022-11-17
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Han, Euidon
  • Lee, Sanghun
  • Chon, Chan Hee
  • Kim, Dong Hoon
  • Kim, Ju Hee

Abstract

A chip for preparing lipid nanoparticles comprises: a mixer unit which mixes a first raw material including mRNA and a second raw material including lipids to form a mixed solution; a dilution unit which is connected to the mixer unit and dilutes the mixed solution by using a diluent; and a concentration unit which is connected to the dilution unit and concentrates lipid nanoparticles (LNPs) from the diluted mixed solution to obtain a concentrate.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • B01F 33/30 - Micromixers
  • B01F 33/301 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
  • B01F 25/00 - Flow mixersMixers for falling materials, e.g. solid particles
  • B01F 23/80 - After-treatment of the mixture

40.

SUSTAINED-RELEASE MICROPARTICLES FOR SUSTAINED RELEASE OF DRUG

      
Application Number 17762701
Status Pending
Filing Date 2021-09-06
First Publication Date 2022-10-27
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Donghoon
  • Kim, Seyeon

Abstract

The present disclosure provides sustained-release microparticles comprising a biodegradable polymer and a drug, wherein the biodegradable polymer and the drug are uniformly distributed throughout the particles, and the microparticles do not show an initial excessive release of the drug, and are composed of uniform-sized particles having a particle size distribution width of 35 microns or less analyzed by a particle size analyzer and a specific surface area of the microparticles of 0.75×10−1 to 2.0×10−1 m2/g, thereby exhibiting a sustained release pattern of the drug. The injection composition comprising the drug contained in such microparticles can control the release of the drug for a selected period during injection administration to release an effective drug concentration constantly, and when formulated as an injection product, can reduce foreign body sensation and pain to the subject to enable an injection formulation with high compliance to be provided.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
  • A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
  • A61K 38/22 - Hormones
  • A61K 38/08 - Peptides having 5 to 11 amino acids

41.

LIPID NANOPARTICLE PREPARATION METHOD AND PREPARATION APPARATUS THEREFOR

      
Application Number KR2022005796
Publication Number 2022/225368
Status In Force
Filing Date 2022-04-22
Publication Date 2022-10-27
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Chung, Jinyang
  • Park, Hyochan
  • Chon, Chan Hee
  • Kim, Donghoon
  • Kim, Ju Hee

Abstract

The present invention relates to a lipid nanoparticle preparation method and a preparation apparatus therefor. Since a separate process for selecting prepared lipid nanoparticles is not required, production yield can be increased in a sterilization and filtration process and the like of a downstream stage. In addition, the present invention can prepare lipid nanoparticles which have a uniform size and have, by deviating from a conventional optimum drug and lipid ratio, the reduced amount of ionized lipid of which toxicity is problematic when administered into the body.

IPC Classes  ?

  • B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
  • C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
  • C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
  • B82Y 40/00 - Manufacture or treatment of nanostructures

42.

SUSTAINED FORMULATION FOR PREVENTION OR TREATMENT OF AUTOIMMUNE DISEASE CONTAINING NALTREXONE AND METHOD USING SAME

      
Document Number 03208374
Status Pending
Filing Date 2022-03-08
Open to Public Date 2022-09-15
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Mase
  • Kim, Donghoon

Abstract

Provided are: a sustained formulation, for prevention or treatment of an autoimmune disease, containing naltrexone or a pharmaceutically acceptable salt thereof, and microparticles comprising a biodegradable polymer; and a method using same. The present invention may be used for continuous and long-term prevention or treatment of an autoimmune disease by means of a single administration.

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
  • A61P 37/00 - Drugs for immunological or allergic disorders

43.

SUSTAINED FORMULATION FOR PREVENTION OR TREATMENT OF AUTOIMMUNE DISEASE CONTAINING LOW-DOSE NALTREXONE AND METHOD USING SAME

      
Application Number KR2022003317
Publication Number 2022/191615
Status In Force
Filing Date 2022-03-08
Publication Date 2022-09-15
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Mase
  • Kim, Donghoon

Abstract

Provided are: a sustained formulation, for prevention or treatment of an autoimmune disease, containing naltrexone or a pharmaceutically acceptable salt thereof, and microparticles comprising a biodegradable polymer; and a method using same. The present invention may be used for continuous and long-term prevention or treatment of an autoimmune disease by means of a single administration.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
  • A61P 37/00 - Drugs for immunological or allergic disorders

44.

SUSTAINED-RELEASE MICROPARTICLES FOR SUSTAINED RELEASE OF DRUG

      
Application Number 17723155
Status Pending
Filing Date 2022-04-18
First Publication Date 2022-08-11
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Donghoon
  • Kim, Seyeon
  • Lee, Sang No

Abstract

The present disclosure provides sustained-release microparticles comprising a biodegradable polymer and a drug, wherein the biodegradable polymer and the drug are uniformly distributed throughout the particles, and the microparticles do not show an initial excessive release of the drug, and are composed of uniform-sized particles having a particle size distribution width of 35 microns or less analyzed by a particle size analyzer and a specific surface area of the microparticles of 0.75×10−1 to 2.0×10−1 m2/g, thereby exhibiting a sustained release pattern of the drug. The injection composition comprising the drug contained in such microparticles can control the release of the drug for a selected period during injection administration to release an effective drug concentration constantly, and when formulated as an injection product, can reduce foreign body sensation and pain to the subject to enable an injection formulation with high compliance to be provided.

IPC Classes  ?

  • A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
  • A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
  • A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
  • A61K 38/26 - Glucagons
  • A61K 38/09 - Luteinising hormone-releasing hormone [LHRH]Related peptides
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

45.

SUSTAINED-RELEASE MICROPARTICLES CONTAINING DESLORELIN, AND PREPARATION METHOD THEREFOR

      
Application Number 17605185
Status Pending
Filing Date 2020-01-14
First Publication Date 2022-06-30
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Se Yeon

Abstract

According to sustained-release microparticles containing deslorelin, and a preparation method therefor, of the present invention, sustained-release microparticles containing deslorelin in a formulation for subcutaneous administration are provided so that pain can be relieved during administration to animals, and a chemical castration effect can last for 2 to 36 months. In addition, the present invention is effective as a chemical castration agent for 2 to 8 months so as to have an excellent of removing boar taint.

IPC Classes  ?

  • A61K 38/09 - Luteinising hormone-releasing hormone [LHRH]Related peptides
  • A61K 9/113 - Multiple emulsions, e.g. oil-in-water-in-oil
  • A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
  • A61K 9/00 - Medicinal preparations characterised by special physical form

46.

SOLVENT-REMOVING APPARATUS AND METHOD FOR PRODUCING MICROSPHERES USING SAME

      
Application Number KR2021018252
Publication Number 2022/139242
Status In Force
Filing Date 2021-12-03
Publication Date 2022-06-30
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Chon, Chan Hee

Abstract

This solvent-removing apparatus comprises: a tank body accommodating an emulsion comprising first source material in a continuous phase and second source material in a dispersed phase; a fluid supply unit for supplying fluid into the tank body to cause the emulsion to circulate; and a discharge unit for discharging the gas in the tank body to the outside.

IPC Classes  ?

  • B01D 11/04 - Solvent extraction of solutions which are liquid
  • B01D 1/30 - Accessories for evaporators
  • B01D 35/02 - Filters adapted for location in special places, e.g. pipe-lines, pumps, stop-cocks
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

47.

INJECTABLE COMPOSITION FOR TISSUE REPAIR AND METHOD FOR PREPARING SAME

      
Application Number KR2021008513
Publication Number 2022/124508
Status In Force
Filing Date 2021-07-05
Publication Date 2022-06-16
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Sang No
  • Oh, Hyun Suk

Abstract

The present invention relates to an injectable composition for tissue repair and a method for preparing same, in which a short-term tissue repair effect and a long-term tissue repair effect by inducing collagen production can be provided, and skin health damaged by aging and irritation can be restored. The present invention also provides: an injectable composition for tissue repair, which is a ready-to-use injectable composition without the need for dilution before use, and thus can be immediately used, and is uniformly dispersed, thus exhibiting a uniform tissue repair effect; and a method for preparing same.

IPC Classes  ?

  • A61L 27/26 - Mixtures of macromolecular materials
  • A61L 27/20 - Polysaccharides
  • A61L 27/58 - Materials at least partially resorbable by the body
  • A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

48.

MICROSPHERE MANUFACTURING SYSTEM AND MICROSPHERE MANUFACTURING METHOD

      
Application Number KR2021010078
Publication Number 2022/114450
Status In Force
Filing Date 2021-08-02
Publication Date 2022-06-02
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Chon, Chan Hee

Abstract

A microsphere manufacturing system comprises: a first raw material storing unit for storing a first raw material; a second raw material storing unit for storing a second raw material including a solvent, a biodegradable polymer, and a drug; an emulsion generating unit for continuously forming an emulsion including the first raw material in a continuous phase and the second raw material in a dispersed phase; a first solvent extracting and removing unit which accommodates the emulsion formed by the emulsion generating unit, and extracts and removes the solvent from the dispersed phase of the emulsion so as to form microspheres; and a second solvent extracting and removing unit which is spaced apart from the first solvent extracting and removing unit, accommodates the emulsion formed by the emulsion generating unit, and extracts and removes the solvent from the dispersed phase of the emulsion so as to form microspheres.

IPC Classes  ?

  • B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/107 - Emulsions

49.

SUSTAINED-RELEASE MICROPARTICLES FOR SUSTAINED RELEASE OF DRUG

      
Application Number KR2021012001
Publication Number 2022/050783
Status In Force
Filing Date 2021-09-06
Publication Date 2022-03-10
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Dong Hoon
  • Kim, Se Yeon

Abstract

The present invention provides sustained-release microparticles exhibiting a sustained release pattern of a drug, the microparticles comprising a biodegradable polymer and a drug, wherein the biodegradable polymer and drug are uniformly distributed throughout the entirety of the particles, and the microparticles do not exhibit initial burst release of the drug, have a particle size distribution width, analyzed by a particle size analyzer, of at most 35 microns, and are configured so as to have a uniform particle size by having a specific surface area of 0.75x10-1to 2.0x10-1m2/g. An injection composition comprising the drug contained in such microparticles controls the release of the drug during a selected duration when administered via injection so as to enable an effective concentration of the drug to be released at a constant rate, and, when formulated into an injection, may reduce foreign body sensation and pain in a subject, and thus an injection formulation having high compliance may be provided.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
  • A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
  • A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
  • A61K 38/08 - Peptides having 5 to 11 amino acids

50.

Multichannel manufacturing device for mass production of microspheres

      
Application Number 17417968
Grant Number 12023645
Status In Force
Filing Date 2020-07-28
First Publication Date 2022-03-10
Grant Date 2024-07-02
Owner INVENTAGE LAB. INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Oh, Hyun Suk

Abstract

In the present invention, two adjacent supply lines for supplying two immiscible fluids are spirally disposed on a substrate where microchannels for microsphere production based on a droplet-based highly controlled method for mass-production of microspheres (HCMMM) are formed, and microsphere forming parts each comprising microchannels are arranged between and along the two supply lines, whereby a much larger amount of microspheres can be produced. Further, the two supply lines are disposed in a spiral configuration, and the microsphere forming parts can be disposed by branching microchannels from the two supply lines on inner and outer sides of the spiral configuration, whereby the limited space on a wafer normally having a circular shape can be maximally used to form multiple microsphere forming parts.

IPC Classes  ?

  • B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
  • B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying

51.

SYSTEM FOR PRODUCING MICROPARTICLES, COMPRISING CARRIER FLUID, AND METHOD FOR CONTROLLING SAME

      
Application Number KR2021001075
Publication Number 2021/157942
Status In Force
Filing Date 2021-01-27
Publication Date 2021-08-12
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Dong Hoon
  • Chon, Chan Hee

Abstract

The invention disclosed in the present specification relates to a system for producing microparticles by using microfluidics and a method for controlling same and, in particular, provides: a system for producing microparticles, in which, as compared to the prior art, droplets produced using microfluidics can be stably transported without agglomerating or being destroyed; and a method for controlling the system so that the droplets can be more stably transported under the system. By the system for producing microparticles and the method for controlling same disclosed in the present specification, droplets produced by the system for producing microparticles by using microfluidics can be stably transported without agglomerating or being destroyed, thus enabling more efficient microparticle production.

IPC Classes  ?

  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

52.

Microparticles containing dutasteride, and preparation method therefor

      
Application Number 17056711
Grant Number 11911508
Status In Force
Filing Date 2019-05-20
First Publication Date 2021-07-08
Grant Date 2024-02-27
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Se Yeon

Abstract

The present invention relates to: sustained-release microparticles capable of maintaining, for a long time, effects of preventing, treating or alleviating benign prostatic hyperplasia and prostate cancer and effects of preventing hair loss and promoting hair growth according to the administration of microparticles containing dutasteride; and a preparation method therefor, and according to the use of a method for administering the particles to a patient through an injection, a patient does not have to directly store or handle the microparticles, unlike an oral dosage form, and thus storage and handling are simple. In addition, drug effects are maintained for a long period of time of 1-3 months and, simultaneously, administration through injection can be facilitated since foreign body sensation and pain are reduced when being administered to a patient through injection because of the constant average diameter of the particles.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

53.

Sustained-release injectable composition comprising finasteride

      
Application Number 17129028
Grant Number 11484495
Status In Force
Filing Date 2020-12-21
First Publication Date 2021-06-24
Grant Date 2022-11-01
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Se Yeon

Abstract

The present disclosure relates to a sustained-release injectable composition comprising finasteride, and when the composition is injected as an injection formulation, it is possible to maintain a constant blood concentration for a long time without initial over-release in terms of the degree of release of finasteride, and when the composition is administrated by subcutaneous injection, it is possible to maintain the effect of treating hair loss and benign prostatic hyperplasia continuously for 1 to 3 months.

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/10 - DispersionsEmulsions
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • A61K 47/02 - Inorganic compounds
  • A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

54.

COMPOSITION FOR SUBCUTANEOUS INJECTION, CONTAINING DEOXYCHOLIC ACID, AND PREPARATION METHOD THEREFOR

      
Application Number 17048408
Status Pending
Filing Date 2019-04-16
First Publication Date 2021-06-03
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Sang No

Abstract

The present invention relates to a composition for subcutaneous injection, containing deoxycholic acid, and a preparation method therefor. The present invention relates to a composition for non-surgical removal of localized fat deposits, the composition being micro-particles, which comprise deoxycholic acid and a biodegradable polymer, wherein the microparticles are formed such that deoxycholic acid is evenly distributed in a spherical biodegradable polymer. According to the present invention, a lipolysis effect lasts for 1 to 3 months from a single injection, a phenomenon in which surrounding tissues are destroyed during administration is prevented, and a drug release effect can be maintained at an effective amount of adipolysis concentration.

IPC Classes  ?

  • A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/50 - Microcapsules

55.

INJECTABLE COMPOSITION FOR TISSUE REPAIR AND PREPARATION METHOD THEREFOR

      
Application Number KR2019010680
Publication Number 2021/033810
Status In Force
Filing Date 2019-08-22
Publication Date 2021-02-25
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Oh, Hyun Suk
  • Choi, Ha Rim

Abstract

The present invention relates to an injectable composition for tissue repair. According to the present invention, an injectable composition for tissue repair and a method for preparing same can be provided, in which the injectable composition as a ready-to-use injectable composition without the need for dilution before use induces an immediate tissue repair effect and collagen production, thus exhibiting a long-lasting tissue repair effect, and further comprises a polynucleotide, and thus can restore skin health damaged by aging and stimuli, through improvement in physiological environments in the body. In addition, in the injectable composition for tissue repair according to the present invention, natural extracts are uniformly mixed in microparticles using a biodegradable polymer, and thus, when the microparticles are injected as an injection, the occurrence of side effects such as inflammatory responses, edema, and dermal necrosis can be prevented.

IPC Classes  ?

  • A61L 27/26 - Mixtures of macromolecular materials
  • A61L 27/20 - Polysaccharides
  • A61L 27/54 - Biologically active materials, e.g. therapeutic substances
  • A61L 27/58 - Materials at least partially resorbable by the body
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 36/23 - Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
  • A61K 36/886 - Aloeaceae (Aloe family), e.g. aloe vera
  • A61K 9/00 - Medicinal preparations characterised by special physical form

56.

MULTICHANNEL MANUFACTURING DEVICE FOR MASS PRODUCTION OF MICROSPHERES

      
Application Number KR2020009931
Publication Number 2021/029573
Status In Force
Filing Date 2020-07-28
Publication Date 2021-02-18
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Oh, Hyun Suk

Abstract

In the present invention, two adjacent supply lines for supplying two immiscible fluids are spirally disposed on a substrate where microchannels for microsphere production based on a droplet-based highly controlled method for mass-production of microspheres (HCMMM) are formed, and microsphere forming parts each comprising microchannels are arranged between and along the two supply lines, whereby a much larger amount of microspheres can be produced. Further, the two supply lines are disposed in a spiral configuration, and the microsphere forming parts can be disposed by branching microchannels from the two supply lines on inner and outer sides of the spiral configuration, whereby the limited space on a wafer normally having a circular shape can be maximally used to form multiple microsphere forming parts.

IPC Classes  ?

  • B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61J 3/00 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus

57.

METHOD FOR PREPARING COMPOSITION POWDER FOR FEMININE WASH CONTAINING PROPOLIS AND NATURAL EXTRACT

      
Application Number KR2020008349
Publication Number 2021/006507
Status In Force
Filing Date 2020-06-26
Publication Date 2021-01-14
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Ryu, Choong Ho

Abstract

The present invention relates to a method for preparing a composition powder for a feminine wash containing propolis and a natural extracts, wherein the composition powder for a feminine wash contributes to improvements in ease of use, convenience of storage, and shelf life of a composition product for a feminine wash.

IPC Classes  ?

  • A61K 8/98 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution of animal origin
  • A61K 8/65 - CollagenGelatinKeratinDerivatives or degradation products thereof
  • A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K 8/9794 - Liliopsida [monocotyledons]
  • A61K 8/9771 - Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
  • A61K 8/9789 - Magnoliopsida [dicotyledons]
  • A61K 8/67 - Vitamins
  • A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
  • A61Q 19/10 - Washing or bathing preparations

58.

Microparticles containing moxidectin, and preparation method therefor

      
Application Number 16771196
Grant Number 11931461
Status In Force
Filing Date 2018-09-05
First Publication Date 2020-12-03
Grant Date 2024-03-19
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention relates to microparticles comprising moxidectin and a biodegradable polymer, wherein the microparticles comprising moxidectin have a shape allowing a moxidectin drug to be uniformly distributed in spherical biodegradable polymer particles, and the average particle diameter of the microparticles is 80-130 μm. The present invention relates to: extended release microparticles capable of continuously maintaining a heartworm disease prevention effect for 3 months to 6 months by administering microparticles comprising moxidectin; and a preparation method therefor. In addition, the present invention is prepared such that the average diameters of the particles have a predetermined micrometer size, and thus reduces a foreign body sensation and pain during administration into an animal through injection, thereby enabling administration through injection to be facilitated.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline

59.

SUSTAINED-RELEASE MICROPARTICLES CONTAINING DESLORELIN, AND PREPARATION METHOD THEREFOR

      
Application Number KR2020000657
Publication Number 2020/222399
Status In Force
Filing Date 2020-01-14
Publication Date 2020-11-05
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Se Yeon

Abstract

According to sustained-release microparticles containing deslorelin, and a preparation method therefor, of the present invention, sustained-release microparticles containing deslorelin in a formulation for subcutaneous administration are provided so that pain can be relieved during administration to animals, and a chemical castration effect can last for 2 to 36 months. In addition, the present invention is effective as a chemical castration agent for 2 to 8 months so as to have an excellent effect of removing boar taint.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/113 - Multiple emulsions, e.g. oil-in-water-in-oil
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 38/09 - Luteinising hormone-releasing hormone [LHRH]Related peptides
  • A61P 15/00 - Drugs for genital or sexual disordersContraceptives

60.

SUSTAINED-RELEASE MICROPARTICLES CONTAINING DESLORELIN, AND PREPARATION METHOD THEREFOR

      
Document Number 03137819
Status In Force
Filing Date 2020-01-14
Open to Public Date 2020-11-05
Grant Date 2024-01-09
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Se Yeon

Abstract

According to sustained-release microparticles containing deslorelin, and a preparation method therefor, of the present invention, sustained-release microparticles containing deslorelin in a formulation for subcutaneous administration are provided so that pain can be relieved during administration to animals, and a chemical castration effect can last for 2 to 36 months. In addition, the present invention is effective as a chemical castration agent for 2 to 8 months so as to have an excellent effect of removing boar taint.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/113 - Multiple emulsions, e.g. oil-in-water-in-oil
  • A61K 38/09 - Luteinising hormone-releasing hormone [LHRH]Related peptides
  • A61P 15/00 - Drugs for genital or sexual disordersContraceptives

61.

COMPOSITION FOR SUBCUTANEOUS INJECTION CONTAINING MICROPARTICLES COMPRISING FINASTERIDE

      
Application Number KR2020000008
Publication Number 2020/166820
Status In Force
Filing Date 2020-01-02
Publication Date 2020-08-20
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention provides a composition for subcutaneous injection containing microparticles comprising finasteride, the composition comprising: microparticles comprising finasteride and biodegradable polymer; and a suspension solvent. The composition for subcutaneous injection of the present invention is provided in a subcutaneously injectable form, not in an oral administration form, and thus there is no need for a user to store the composition, and a hair loss treatment effect by finasteride can be exhibited through a method of direct administration at a hospital, and thus ease of storage and handling is excellent. When microparticles comprising finasteride are administered using the composition for subcutaneous injection of the present invention, a long-term drug administration effect over a period of 1-3 months can be maintained. In addition, in the present invention, as the diameter of particles is formed to a uniform micro-size, the release of a drug from microparticles is controlled, thereby enabling an effective drug concentration to be constantly maintained, and the present invention can be provided as a composition for injection, in which, when applied to an injection consisting of a uniform size of particles and administered as an injection to a patient, the sense of foreign matter and pain are reduced.

IPC Classes  ?

  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/10 - DispersionsEmulsions
  • A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
  • A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

62.

Extended release microparticles comprising drug, and preparation method therefor

      
Application Number 16757604
Grant Number 11504688
Status In Force
Filing Date 2018-10-16
First Publication Date 2020-08-20
Grant Date 2022-11-22
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention relates to extended release microparticles comprising a drug, and a preparation method therefor, and when the extended release microparticles comprising a drug are administered in order to replace conventional drugs that should be administered daily or monthly, the drug administration effect can be continuously maintained for one week to three months. In addition, the drug administration effect is maintained for a long time and, simultaneously, microparticles are prepared so as to have the average diameter of a fixed micro-size, and thus an effective drug concentration can be constantly maintained by controlling the release of the drug from the microparticles, and a foreign body sensation and pain can be reduced during drug administration since microparticles having a uniform size are included during application as an injectable drug.

IPC Classes  ?

  • B01J 13/06 - Making microcapsules or microballoons by phase separation
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • B01F 33/302 - Micromixers the materials to be mixed flowing in the form of droplets
  • B01F 33/30 - Micromixers
  • B01F 33/3011 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 31/365 - Lactones
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • C08J 5/00 - Manufacture of articles or shaped materials containing macromolecular substances
  • B01J 2/06 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
  • B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops

63.

Microparticles containing finasteride and preparation method thereof

      
Application Number 16639810
Grant Number 11344624
Status In Force
Filing Date 2018-08-17
First Publication Date 2020-08-06
Grant Date 2022-05-31
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention relates to microparticles containing finasteride, as microparticles containing finasteride and a biodegradable polymer, in a form in which the microparticles have a shape in which the finasteride drug is uniformly distributed in spherical biodegradable polymer particles, and the microparticles have an average particle diameter of 20 to 70 μm. The present invention relates to sustained-release microparticles which can maintain the effect of treating alopecia sustainably for 1 month to 3 months as the microparticles containing finasteride are administered, and a preparation method thereof, and the present invention may facilitate storage and handling of microparticles containing finasteride unlike oral dosage forms as a patient need not directly store and handle the microparticles by using the microparticles containing finasteride in a manner that the microparticles are administered to the patient through injection, maintain the drug effect for a long period of time such as 1 month to 3 months, and facilitate the administration as an injection by decreasing a foreign body sensation and pain at the time of administering the injection to a patient as the particles are prepared to have the average diameter of the particles to a certain micro size.

IPC Classes  ?

  • A61K 47/59 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
  • A61K 9/50 - Microcapsules
  • A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

64.

Method for preparing pharmaceutical composition for preventing or treating cognitive impairment-related disease and pharmaceutical composition for preventing or treating cognitive impairment-related disease prepared by the same

      
Application Number 16652065
Grant Number 11400085
Status In Force
Filing Date 2019-03-19
First Publication Date 2020-08-06
Grant Date 2022-08-02
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Sang No

Abstract

The present invention relates to a method for preparing a pharmaceutical composition for preventing or treating a cognitive impairment-related disease and a pharmaceutical composition for preventing or treating a cognitive impairment-related disease prepared by the same, and the pharmaceutical composition includes microparticles including donepezil and a biodegradable polymer, and the microparticles are in a form in which donepezil is uniformly distributed in a spherical biodegradable polymer. The present invention may maintain the effect of preventing or treating the cognitive impairment-related disease for 1 month by a single injection in order to eliminate the inconvenience of having to take the composition daily, and as the present invention is prepared by maintaining the average diameters of the particles at a predetermined micrometer size, a foreign body sensation and pain during administration into a patient as an injection is reduced, thereby enabling administration as an injection to be facilitated.

IPC Classes  ?

  • A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

65.

Apparatus for a mass production of monodisperse biodegradeable polymer-based microspheres and a multi-channel forming device incorporatable therein

      
Application Number 16806961
Grant Number 11819816
Status In Force
Filing Date 2020-03-02
First Publication Date 2020-06-25
Grant Date 2023-11-21
Owner INVENTAGE LAB, INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

Provided is an apparatus for a mass production of microspheres and a multichannel forming device incorporatable therein. The apparatus includes a multi-channel microsphere forming unit, a first source material reservoir containing the first source material and in fluid communication with the plurality of first microchannels, a second source material reservoir containing the second source material and in fluid communication with the plurality of second microchannels, a flow control unit configured to supply a first gas to the first source material reservoir at a first source material flow rate and to supply a second gas to a second source material reservoir at a second source material flow rate and a product reservoir for accommodating the microspheres formed from the multi-channel forming unit.

IPC Classes  ?

  • B01J 13/06 - Making microcapsules or microballoons by phase separation
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • B01F 33/302 - Micromixers the materials to be mixed flowing in the form of droplets
  • B01F 33/30 - Micromixers
  • B01F 33/3011 - Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 31/365 - Lactones
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • C08J 5/00 - Manufacture of articles or shaped materials containing macromolecular substances
  • B01J 2/06 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
  • B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops

66.

MICROPARTICLES CONTAINING DUTASTERIDE, AND PREPARATION METHOD THEREFOR

      
Application Number KR2019005986
Publication Number 2019/225924
Status In Force
Filing Date 2019-05-20
Publication Date 2019-11-28
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Kim, Se Yeon

Abstract

The present invention relates to: sustained-release microparticles capable of maintaining, for a long time, effects of preventing, treating or alleviating benign prostatic hyperplasia and prostate cancer and effects of preventing hair loss and promoting hair growth according to the administration of microparticles containing dutasteride; and a preparation method therefor, and according to the use of a method for administering the particles to a patient through an injection, a patient does not have to directly store or handle the microparticles, unlike in an oral dosage form, and thus storage and handling are simple. In addition, drug effects are maintained for a long period of time of 1-3 months and, simultaneously, administration through injection can be facilitated since foreign body sensation and pain are reduced when being administered to a patient through injection because of the constant average diameter of the particles.

IPC Classes  ?

  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • A61P 13/08 - Drugs for disorders of the urinary system of the prostate
  • A61P 35/00 - Antineoplastic agents
  • A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia

67.

COMPOSITION FOR SUBCUTANEOUS INJECTION, CONTAINING DEOXYCHOLIC ACID, AND PREPARATION METHOD THEREFOR

      
Application Number KR2019004587
Publication Number 2019/203543
Status In Force
Filing Date 2019-04-16
Publication Date 2019-10-24
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Sang No

Abstract

The present invention relates to a composition for subcutaneous injection, containing deoxycholic acid, and a preparation method therefor. The present invention relates to a composition for non-surgical removal of localized fat deposits, the composition being microparticles, which comprise deoxycholic acid and a biodegradable polymer, wherein the microparticles are formed such that deoxycholic acid is evenly distributed in a spherical biodegradable polymer. According to the present invention, a lipolysis effect lasts for 1 to 3 months from a single injection, a phenomenon in which surrounding tissues are destroyed during administration is prevented, and a drug release effect can be maintained at an effective amount of adipolysis concentration.

IPC Classes  ?

  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
  • A61P 3/04 - AnorexiantsAntiobesity agents

68.

METHOD FOR PREPARING PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING COGNITIVE DISORDER-ASSOCIATED DISEASES, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING COGNITIVE DISORDER-ASSOCIATED DISEASES, PREPARED BY PREPARATION METHOD

      
Application Number KR2019003158
Publication Number 2019/182319
Status In Force
Filing Date 2019-03-19
Publication Date 2019-09-26
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Kim, Ju Hee
  • Lee, Sang No

Abstract

The present invention relates to a method for preparing a pharmaceutical composition for preventing or treating cognitive disorder-associated diseases, and a pharmaceutical composition for preventing or treating cognitive disorder-related diseases, prepared by the preparation method, the pharmaceutical composition containing microparticles comprising donepezil and a biodegradable polymer, wherein the microparticles are formed such that donepezil is uniformly dispersed in a spherical biodegradable polymer. The present invention can maintain an effect of preventing or treating cognitive disorder-associated diseases for a month with one injection in order to solve the inconvenience of daily drug administration. In addition, since preparation is carried out such that the average diameter of particles is maintained in a predetermined micro-size, a foreign body sensation and pain are reduced during administration to a patient by injection, and thus administration by injection can be facilitated.

IPC Classes  ?

  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 31/13 - Amines, e.g. amantadine
  • A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
  • A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

69.

Inventage

      
Application Number 1485572
Status Registered
Filing Date 2019-07-05
Registration Date 2019-07-05
Owner Inventage Lab Inc. (Republic of Korea)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 10 - Medical apparatus and instruments
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

Infusions (medicinal -); implantable medicines; pharmaceutical compositions; medicines for human purposes; drugs for medical purposes; therapeutic drugs and agents; chemical preparations for pharmaceutical purposes. Medical apparatus and instruments; medical instruments; medical filler apparatus; medical apparatus and instruments for administering pharmaceuticals; diagnostic apparatus and instruments for medical purposes; injection device for pharmaceuticals; apparatus for administering pharmaceuticals. Biological research; biotechnological research; research relating to pharmaceuticals; medical research in the field of crude drugs; medical research; clinical studies of medicines; scientific research for medical purposes; medical and pharmacological research services; pharmaceutical products development; research and development of technology for biotechnology; research and development of medical equipment.

70.

INVENTAGE

      
Serial Number 79266586
Status Registered
Filing Date 2019-07-05
Registration Date 2020-06-09
Owner Inventage Lab Inc. (Republic of Korea)
NICE Classes  ?
  • 05 - Pharmaceutical, veterinary and sanitary products
  • 10 - Medical apparatus and instruments

Goods & Services

Medicinal infusions for treating dementia, diabetes, obesity, andropathy, alopecia, incurable disease, chronic disease, lipolysis, and boosting the immune system; Medicinal infusions for treating dirofilaria immitis diseases, infectious diseases, skeletal and muscular disorders, cardiovascular and circulatory diseases, nervous system diseases, ocular disorders, respiratory diseases, gastrointestinal diseases, endocrine diseases, kidney diseases, hormonal diseases, and oncological diseases and disorders of animals; implantable medicines in the nature of surgical implants comprised of living tissues; pharmaceutical compositions for the prevention and treatment of ocular disorders or diseases, for the treatment of bacteria-based diseases, and for the treatment of diabetes, and anti-infective preparations, antiviral preparations, antibiotics, antifungal preparations and vaccines; pharmaceutical compositions for animal skincare; pharmaceutical compositions for skin care; pharmaceutical compositions for treating dirofilaria immitis diseases, infectious diseases, skeletal and muscular disorders, cardiovascular and circulatory diseases, nervous system diseases, ocular disorders, respiratory diseases, gastrointestinal diseases, endocrine diseases, kidney diseases, hormonal diseases, and oncological diseases and disorders of animals; medicines for human purposes, namely, medicines for the treatment of viral, metabolic, endocrine, musculoskeletal, cardiovascular, cardiopulmonary, genitourinary, sexual dysfunction, oncological, hepatological, ophthalmic, respiratory, neurological, gastrointestinal, hormonal, dermatological, psychiatric and immune system related diseases and disorders; drugs in the nature of pharmaceutical preparations for medical purposes, namely, for the treatment of oncological, gastrointestinal, metabolic, chronic, endocrine, respiratory, neurological and ophthalmic diseases and disorders; therapeutic drugs and agents in the nature of therapeutic pharmaceutical and agents for the treatment of oncological, gastrointestinal, metabolic, chronic, endocrine, respiratory, neurological and ophthalmic diseases and disorders; therapeutic drugs and agents in the nature of therapeutic pharmaceutical and agents for treating dirofilaria immitis diseases, infectious diseases, skeletal and muscular disorders, cardiovascular and circulatory diseases, nervous system diseases, ocular disorders, respiratory diseases, gastrointestinal diseases, endocrine diseases, kidney diseases, hormonal diseases, and oncological diseases and disorders of animals; chemical preparations for pharmaceutical purposes, namely, for the treatment of oncological, gastrointestinal, metabolic, chronic, endocrine, respiratory, neurological and ophthalmic diseases and disorders Medical apparatus and instruments for use in endovascular, cardiovascular, and endoscopy procedures; medical instruments for use in drug delivery systems; medical instruments for use in monitoring oxymetory, gas analysis, vital signs, blood properties and respiratory events; medical instruments for use in treating osteoarthritis, osteoporosis, osteotraumatic injuries, degenerative bone diseases and joint diseases; medical instruments to measure blood pressure, cardiac output and other physiological and cardiovascular parameters; medical instruments for diagnostic use, namely, apparatus for medical diagnostic testing in the fields of cancer or other tissue-based diagnostic testing, cytology and cell-based testing; medical filler apparatus in the nature of synthetic filler and extender material to serve as replacement for bone; medical apparatus and instruments, namely, infusion and injection devices for administering pharmaceuticals; diagnostic apparatus and instruments for medical purposes, namely, medical diagnostic apparatus for testing blood sugar levels, cancer cells, DNA, urinary protein, and cholesterol level; injection device for pharmaceuticals; medical apparatus, namely, infusion and injection devices for administering pharmaceuticals

71.

EXTENDED RELEASE MICROPARTICLES COMPRISING DRUG, AND PREPARATION METHOD THEREFOR

      
Application Number KR2018012180
Publication Number 2019/078583
Status In Force
Filing Date 2018-10-16
Publication Date 2019-04-25
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention relates to extended release microparticles comprising a drug, and a preparation method therefor, and when the extended release microparticles comprising a drug are administered in order to replace conventional drugs that should be administered daily or monthly, the drug administration effect can be continuously maintained for one week to three months. In addition, the drug administration effect is maintained for a long time and, simultaneously, particles are prepared so as to have the average diameter of a fixed micro-size, and thus an effective drug concentration can be constantly maintained by controlling the release of the drug from the microparticles, and a foreign body sensation and pain can be reduced during drug administration since microparticles having a uniform size are included during application as an injectable drug.

IPC Classes  ?

  • B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 31/365 - Lactones
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • C08J 5/00 - Manufacture of articles or shaped materials containing macromolecular substances
  • B01J 13/06 - Making microcapsules or microballoons by phase separation
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

72.

MICROPARTICLES COMPRISING MOXIDECTIN, AND PREPARATION METHOD THEREFOR

      
Application Number KR2018010324
Publication Number 2019/050259
Status In Force
Filing Date 2018-09-05
Publication Date 2019-03-14
Owner INVENTAGELAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention relates to microparticles comprising moxidectin and a biodegradable polymer, wherein the microparticles comprising moxidectin have a shape allowing a moxidectin drug to be uniformly distributed in spherical biodegradable polymer particles, and the average particle diameter of the microparticles is 80-130 μm. The present invention relates to: extended release microparticles capable of continuously maintaining a heartworm disease prevention effect for 3-6 months by administering microparticles comprising moxidectin; and a preparation method therefor. In addition, the present invention is prepared such that the average diameters of the particles have a predetermined micrometer size, and thus reduces a foreign body sensation and pain during administration into an animal through injection, thereby enabling administration through injection to be facilitated.

IPC Classes  ?

  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 31/365 - Lactones
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

73.

MICROPARTICLES INCLUDING FINASTERIDE, AND METHOD FOR PRODUCING SAME

      
Application Number KR2018009440
Publication Number 2019/035679
Status In Force
Filing Date 2018-08-17
Publication Date 2019-02-21
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention relates to microparticles including finasteride and a biodegradable polymer, wherein the microparticles are in the form of spherical biodegradable polymer particles having finasteride medication uniformly distributed therein, and the average particle diameter of the microparticles is 20 to 70 µm. The present invention relates to: sustained-release microparticles, wherein the microparticles including finasteride can be administered to continuously maintain a hair-loss treatment effect for 1 to 3 months; and a method for producing the same. Moreover, the present invention involves administering the microparticles including finasteride to a patient via injections, and thus, unlike oral formulations, does not need to be stored or handled by the patient directly. Accordingly, storage and handling are convenient. The pharmaceutical effect of the microparticles is maintained for a long period of 1 to 3 months, and the microparticles are produced to have a uniform and micro-size average particle diameter. As a result, the irritation and pain when administering the microparticles to a patient as an injection are reduced, and thus the microparticles can be easily administered as an injection.

IPC Classes  ?

  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/10 - DispersionsEmulsions
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

74.

Apparatus for a mass production of monodisperse biodegradeable polymer-based microspheres and a multi-channel forming device incorporatable therein

      
Application Number 15788906
Grant Number 10843159
Status In Force
Filing Date 2017-10-20
First Publication Date 2018-05-17
Grant Date 2020-11-24
Owner INVENTAGE LAB, INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

Provided is an apparatus for a mass production of microspheres and a multichannel forming device incorporatable therein. The apparatus comprises a multi-channel microsphere forming unit, a first source material reservoir containing the first source material and in fluid communication with the plurality of first microchannels, a second source material reservoir containing the second source material and in fluid communication with the plurality of second microchannels, a flow control unit configured to supply a first gas to the first source material reservoir at a first source material flow rate and to supply a second gas to a second source material reservoir at a second source material flow rate and a product reservoir for accommodating the microspheres formed from the multi-channel forming unit.

IPC Classes  ?

  • B01J 13/06 - Making microcapsules or microballoons by phase separation
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • B01F 13/00 - Other mixers; Mixing plant, including combinations of dissimilar mixers
  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 31/365 - Lactones
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • C08J 5/00 - Manufacture of articles or shaped materials containing macromolecular substances
  • B01J 2/06 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
  • B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops

75.

Apparatus for a mass production of monodisperse biodegradable polymer-based microspheres and a multi-channel forming device incorporatable therein

      
Application Number 15788930
Grant Number 10632442
Status In Force
Filing Date 2017-10-20
First Publication Date 2018-05-17
Grant Date 2020-04-28
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

A method and an apparatus for a large-scale production of monodisperse microspheres and biodegradable polymer-based drug delivery systems and design optimization method for the apparatus are provided. The method uses a plurality of microchips, each microchip having at least a first pathway, a second pathway and an outlet, wherein the first pathway and the second pathway merge at a cross point being one end of the outlet, and the method comprises preparing a polymer-phase solution including a degradable polymer and a water-phase solution including a surfactant, having the polymer-phase solution flow through the first pathway, having the water-phase solution flow through the second pathway, gathering a mixed solution flowing out of the outlet, and collecting the microspheres by filtering out the water-phase solution.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • B01F 13/00 - Other mixers; Mixing plant, including combinations of dissimilar mixers
  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
  • B01J 2/06 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
  • B01J 13/06 - Making microcapsules or microballoons by phase separation
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 31/365 - Lactones
  • A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
  • C08J 5/00 - Manufacture of articles or shaped materials containing macromolecular substances
  • B01J 2/02 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops

76.

APPARATUS FOR A MASS PRODUCTION OF MONODISPERSE BIODEGRADABLE POLYMER-BASEDMICROSPHERES AND A MULTI-CHANNEL FORMING DEVICE INCORPORATABLE THEREIN

      
Application Number KR2017011913
Publication Number 2018/088731
Status In Force
Filing Date 2017-10-26
Publication Date 2018-05-17
Owner INVENTAGE LAB. INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

Provided is an apparatus for a mass production of microspheres and a multichannel forming device incorporatable therein. The apparatus comprises a multi-channel microsphere forming unit, a first source material reservoir containing the first source material and in fluid communication with the plurality of first microchannels, a second source material reservoir containing the second source material and in fluid communication with the plurality of second microchannels, a flow control unit configured to supply a first gas to the first source material reservoir at a first source material flow rate and to supply a second gas to a second source material reservoir at a second source material flow rate and a product reservoir for accommodating the microspheres formed from the multi-channel forming unit.

IPC Classes  ?

  • B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying
  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus

77.

OPTIMIZATION OF THE DESIGNING OF APPARATUS AND PROCESSES FOR MASS PRODUCTION OF MONODISPERSE BIODEGRADABLE POLYMER-BASED MICROSPHERES AND BIODEGRADABLE POLYMER-BASED DRUG DELIVERY SYSTEMS

      
Application Number KR2017011915
Publication Number 2018/088732
Status In Force
Filing Date 2017-10-26
Publication Date 2018-05-17
Owner INVENTAGE LAB. INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

a method and an apparatus for a large-scale production of monodisperse microspheres and biodegradable polymer-based drug delivery systems and design optimization method for the apparatus are provided. The method uses a plurality of microchips, each microchip having at least a first pathway, a second pathway and an outlet, wherein the first pathway and the second pathway merge at a cross point being one end of the outlet, and the method comprises preparing a polymer-phase solution including a degradable polymer and a water-phase solution including a surfactant, having the polymer-phase solution flow through the first pathway, having the water-phase solution flow through the second pathway, gathering a mixed solution flowing out of the outlet, and collecting the microspheres by filtering out the water-phase solution.

IPC Classes  ?

  • B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying
  • B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

78.

PREPARATION METHOD OF MICROPARTICLES COMPRISING BIODEGRADABLE POLYMER

      
Application Number KR2016006209
Publication Number 2017/014431
Status In Force
Filing Date 2016-06-10
Publication Date 2017-01-26
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor Kim, Ju Hee

Abstract

The present invention relates to a preparation method of microparticles comprising a biodegradable polymer wherein the microparticles prepared according to the present invention are spherical microparticles for injection into the skin. The size of the microparticles can be controlled by using the preparation method. In addition, the microparticles comprising a biodegradable polymer can be produced in a narrow range of size and thus can exhibit a high production yield rate. Considering the characteristic in which a dissolution rate varies according to the size of the microparticles, the dissolution rate can be controlled after injecting the microparticles, prepared according to the present invention, into a body.

IPC Classes  ?

79.

Droplet discharging device

      
Application Number 13375286
Grant Number 08475741
Status In Force
Filing Date 2010-09-14
First Publication Date 2012-08-30
Grant Date 2013-07-02
Owner INVENTAGE LAB INC. (Republic of Korea)
Inventor
  • Cho, Seongjin
  • Lim, Geunbae
  • Kim, Intae

Abstract

Provided is a droplet discharging device that can precisely dispense large flow rate of droplets and small flow rate of droplets selectively. The droplet discharging device according to the present invention includes a pneumatic discharger for discharging a droplet having a first flow rate, and an electronic pipette for discharging or sucking a droplet having a second flow rate equal to or smaller than the first flow rate. The pneumatic discharger includes, i) a storage chamber for storing a liquid, ii) an air tank connected to the storage chamber through a first air pipe and supplying compressed air to the storage chamber to push the liquid of the storage chamber outside, and iii) a first nozzle connected to the storage chamber through the liquid pipe and receiving the liquid pushed out of the storage chamber to discharge droplets.

IPC Classes  ?