The present invention relates to a feed additive for reducing methane production in the rumen of a ruminant animal comprising an isoflavone. In particular, the isoflavone comprises one or more of formononetin, biochanin A and/or precursors thereof. The present invention also relates to a method of reducing methane production in the rumen of a ruminant animal comprising administration of an isoflavone.
A23K 10/30 - Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hayAnimal feeding-stuffs from material of fungal origin, e.g. mushrooms
A23K 20/121 - Heterocyclic compounds containing oxygen or sulfur as hetero atom
A23K 50/10 - Feeding-stuffs specially adapted for particular animals for ruminants
The present invention relates to a method for determining the presence of prostate cancer or benign prostatic hyperplasia (BPH) in a subject. The method comprises: (i) determining the level of one or more biomarkers in a sample from the subject; and (ii) comparing the level of said one or more biomarkers with the level of said one or more metabolites in a control sample to determine whether prostate cancer or BPH is present in the subject. The prostate cancer biomarkers are selected from: 3-hydroxyhexadecanoylcarnitine, alpha lipoic acid and N- heptanoylglycine. The BPH biomarkers are selected from N-lsobutyl-2,4,8, 10,12- tetradecapentaenamide, PE-NMe2(24: 1 (15Z)/20:5(5Z,8Z, 11 Z, 14Z, 17Z)), 1-Phosphatidyl-D- myo-inositol, L-Urobilin, 18-Carboxy-dinor-LTE4, Urobilin/Urobilinogen, 5,6-Dihydrothymine, N-Acetyl-D-Glucosamine 6-Phosphate and cholic acid.
The present invention provides an apparatus for determining the optical characteristics of a gem stone, the apparatus comprising: an integrating sphere (202) having an internal volume defined by an internal surface; a mount (216) for receiving a gem stone (100), such that at least one surface of the gem stone is exposed to the internal volume; a light source (208) configured to project light into the gem stone; a light sensor (212) configured to measure light at least one position on the internal surface of the integrating sphere.
There is disclosed a composition comprising cannabidiol (CBD) and one or more cannabinoids selected from cannabidiolic acid (CBDA), cannabigerol (CBG) and cannabigerolic acid (CBGA) for use in the treatment or prevention of inflammation and disorders associated with inflammation or an IL-6 related disorder.
The present invention relates to a method for determining the presence of Mycobacterium avium paratuberculosis in a subject. The method comprises: (i) determining the level of one or more metabolites in a sample from the subject; and (ii) comparing the level of said one or more metabolites with the level of said one or more metabolites in a control sample to determine whether Mycobacterium aviumparatuberculosis is present in the subject. The metabolites are selected from: 2-hydroxyglutaric acid; leukotriene B4; itaconic acid; bicyclo-prostaglandin E2; N6-acetyl-L-lysine; guanidinobutanoic acid; creatine; docosahexaenoic acid; cis-10-non-adecenoic acid; creatinine; 5-hydroxyeicosapentaenoic acid, 17-hydroxy docosahexaenoic acid, palmitoleic acid; R-3-hydroxy-octade-canoic acid; 8, 11, 14-eicosatrienoic acid; nonadecanoic acid; stearic acid; eicosapentaenoic acid; 16-methylheptadecanoic acid; phytanic acid; arachidonic acid; 9,10-dihydroxy-12-octadecenoic acid, 8,11,14, 17-eicosatetraenoic acid; palmitic acid; pyruvic acid; and p-cresol.
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
7.
ANTIBACTERIAL AND ANTIPARASITIC QUINOXALINE-2,3-DIAMINE DERIVATIVES
University College Cardiff Consultants Limited (United Kingdom)
Aberystwyth University (United Kingdom)
Inventor
Brancale, Andrea
Padalino, Gilda
Hoffman, Karl
Abstract
A compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, for use in the treatment of a patient infected with pathogenic organisms; wherein X and Y are each independently selected from C, N, O and S, provided at least one of X and Y is N, O or S; wherein R1 and R2 are each independently selected from an optionally substituted C1-C8 alkyl, C1-C8 alkenyl, aryl, heteroaryl or alkylaryl group; and wherein Z is selected from H, —CN, —NO2, —NR3R4, —NR5(CO)R6; C1-C4 alkyl, C1-C4 alkoxy, —(CO)WR12, hydroxy, amino, thiol, chloro, fluoro, CF3, CHF2 or CH2F groups. The compounds may be effective in treating patients/animals infected with parasites selected from Schistosoma, Haemonchus, Eimeria, Echinococcus, Dirofilaria, Fasciola or Plasmodium parasites. Additionally or alternatively, the compounds of formula (I) may be effective in treating patients infected with pathogenic bacteria selected from S. aureus, MRSA and Enterococcus faecalis.
C07D 241/44 - Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
There is disclosed a composition comprising cannabidiol (CBD) and one or more cannabinoids selected from cannabidiolic acid (CBDA), cannabigerol (CBG) and cannabigerolic acid (CBGA) for use in the treatment or prevention of inflammation and disorders associated with inflammation or an IL-6 related disorder.
UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (United Kingdom)
Inventor
Brancale, Andrea
Padalino, Gilda
Hoffmann, Karl
Abstract
A compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, for use in the treatment of a patient infected with pathogenic organisms; wherein X and Y are each independently selected from C, N, O and S, provided at least one of X and Y is N, O or S; wherein R1and R2181822, -NR3R4, -NR5(CO)R614144 alkoxy, -(CO)WR12322Schistosoma, Haemonchus, Eimeria, Echinococcus, Dirofilaria, FasciolaPlasmodiumS. aureusEnterococcus faecalis.Enterococcus faecalis.
C07D 241/44 - Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Candida strains comprising a mutation or deletion in the first and/or second XYL2 allele which can be used for producing one or more sugar alcohols from a lignocellulosic feedstock. The preferred sugar alcohol is xylitol.
CandidaXYL2XYL2 allele which can be used for producing one or more sugar alcohols from a lignocellulosic feedstock. The preferred sugar alcohol is xylitol.
The present invention relates to a method for improving outcomes in ruminant feeding, the method comprising administering a composition to the ruminant, the composition comprising a glycosidase inhibiting iminosugar; wherein the improved outcome is selected from one or more of: inhibiting protozoal activity in the rumen of a ruminant; and/or improving ruminant feed efficiency; and/or improving growth performance of a ruminant; and/or reducing greenhouse gas emissions. The invention also relates to a composition comprising a saponin and a glycosidase inhibitor, preferably a glycosidase inhibiting iminosugar.
The present invention relates to synthetic bis esters of hederagenin, and their use in ruminants to improve ruminant growth performance, reduce rumen methane emission, reduce urine ammonia excretion, and/or to reduce rumen acetate to propionate ratio. Moreover, it also relates to a feed composition for ruminants comprising bis esters of hederagenin, and to novel bis esters of hederagenin.
The present invention relates to compounds, in particular derivatives of the diterpenoids sempervirol and 7‐keto‐sempervirol, and their use in therapy, including in pharmaceutical compositions and combinations, especially in the treatment and/or prophylaxis of the tropical diseases schistosomiasis and/or fascioliasis, for example in humans or in non‐human land mammals such as sheep, cattle, other ruminants, or goats.
The present invention relates to methods for the diagnosis of lung cancer (LC) status in a subject by determining the level of at least one specific bacterial species relative to the level of at least one other bacterial species present in a sample which has been obtained from the subject (Fig. 3). The invention further provides a method of diagnosing LC stage in a subject by determining the level of at least one specific bacterial species in a sample which has been obtained from the subject, relative to the level of specific bacterial species in a control. Also provided are kits, biomarkers and treatments for use in the methods described.
Methods of production of an improved combustion fuel product are disclosed in which a first fibrous wetland biomass or feedstock is mechanically squeezed or compressed to produce a liquid and a fibrous plant residue, slow pyrolysis is then used to produce biochar and heat, with the heat of slow pyrolysis used to produce a dried wetland biomass, which is then compacted together with the biochar to form the combustion fuel product.
C10B 53/02 - Destructive distillation, specially adapted for particular solid raw materials or solid raw materials in special form of cellulose-containing material
A composition comprising branched fructan molecules, wherein said branched fructan molecules have; a molecular weight of between about 0.3 to about 3kDa;and/ora fructan chain length of about 2 to about 15 fructose units and/or an elution time of 7 to 22 minutes when on a Dionex HPAEC-PAD column. The invention also embraces a feed or food supplement comprising such compositions, a method of producing a composition comprising branched fructan molecules, and a method of making a feed or foodstuff.
A lipase comprising a polypeptide or peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1-19 and the polynucleotides encoding the lipases is disclosed. The lipases and nucleic acid sequences encoding these lipases can be used in the preparation of polymers, in formulations which may comprise detergents, as catalysts, in the preparation of bioplastics, as part of diagnostic kits, in the preparation of biofuels and for the prevention and/or treatment of a disease.
C07K 16/12 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from bacteria
C12P 7/64 - FatsFatty oilsEster-type waxesHigher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl groupOxidised oils or fats
G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
Biofuel production processes include pressing grass to obtain grass juice; separating liquid from the grass juice; pasteurising the liquid; acidifying and incubating the liquid; and fermenting the liquid in order to produce biofuel including bioethanol.
40 - Treatment of materials; recycling, air and water treatment,
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
45 - Legal and security services; personal services for individuals.
Goods & Services
Business advisory services; business development services; project management services to assist businesses in converting crops and plant matter into bio-products through a bio-refining process; business advisory services relating to product development; business advisory services relating to the exploitation of inventions arising through bio-refining processes; business support services relating to the exploitation of new and existing products; assistance, advice and consultancy in relation to business planning and commercial analysis; economic forecasting and analysis services; provision of economic modelling for businesses; organisation of events and exhibitions for commercial purposes; information, consultancy and advisory services relating to the aforesaid. Treatment of materials; chemical processing services; refining services; bio-refining services; thermochemical processing and mechanical processing of crop and plant matter through bioconversion for the production of bio-products; conversion of biomass and plant matter into bio-char and bio-oil; steam treatment of plant and biomass materials; custom manufacture of bio-products from the processing and conversion of plant matter and biomass; information, consultancy and advisory services relating to the aforesaid. Education and training services; education and training services for businesses relating to the conversion of biomass and plant matter into bio-products to turn plants into commercial products and reduce the impact of climate change; provision of workshops, seminars, conferences and courses relating to the aforesaid; provision of online and electronic publications relating to the aforesaid; information, consultancy and advisory services relating to the aforesaid. Scientific research and development services; industrial analysis and research services; laboratory services; laboratory services relating to the production of bio-products from the conversion of biomass and plant matter; plant biology research, development and analysis; microbiology and biotechnology research, development and analysis; chemical research, development and analysis; chemical analysis of biomass; chemical, plant and biomass testing; environmental testing; technical consulting in the field of environmental science and engineering; testing and certification of bio-products; environmental conservation advisory services; advisory services in the field of product development; product research, design and development from plant and crop biomass; consultancy relating to technology exploitation; information, consultancy and advisory services relating to the aforesaid. Licensing of intellectual property rights; information, consultancy and advisory services relating to the aforesaid.
A method for identifying the connectivity of texture types represented in a digital image comprising pixels, each pixel having a texture value which is representative of texture at a respective position, the method comprising: partitioning the texture values into local neighborhoods of texture values; determining a directionality for each neighborhood; using the directionality of the neighborhoods to determine their nearest neighborhood or neighborhoods; connecting the neighborhoods with their nearest neighborhood or neighborhoods; and determining the connectivity of the texture types of the digital image based on the connections formed between neighborhoods.
A method for producing graphene comprises:- (i) providing a layer of catalyst on a diamond (111) surface, (ii) heating the diamond and/or catalyst layer with a heat source until a desired thickness of graphene is produced on the exposed surface of the catalyst.
A method for analysing sward comprises analysing a sample for the presence of one or more genetic markers. The markers indicate the presence, identity and/or relative abundance of one or more species of plant. This is particularly useful for analyzing the plant species make-up of sports and amenity turf.
The quality of milk can be improved by feeding to ruminants a nutritional composition comprising one or more green odour compounds or one or more derivatives, analogues or homologues thereof. In particularly preferred embodiments, the green odour compounds comprise one or more of hydroperoxides and jasmonates.
Provided are methods for diagnosing lung cancer in a subject or for identifying a subject at risk of developing lung cancer, the method comprising performing FTIR spectral analysis of a sputum sample obtained from the subject and comparing the spectrum produced from the sample with an FTIR spectrum from a normal control. Also provided are methods for detecting early and late stage cancer, methods for monitoring the progression of lung cancer in a subject and kits for use in the described methods.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
28.
METHOD FOR PRODUCING A STRESS TOLERANT PLANT OR PRECURSOR THEREOF
Provided are methods for the production of a stress tolerant plant or precursor thereof. The methods comprise (i) subjecting one or more parental plants to one or more stress conditions selected from unfavourable conditions relating to relative humidity, water availability, periodic drought, nutrients, sunlight, wind, temperature, pH, exogenous chemicals, chemical toxins such as salt, herbivory, prophylactic chemicals, fertilizers, pathogen attack such as bacterial, fungal, or virus infection and pest infestation; and (ii) generating offspring from said one or more parental plants. The offspring show enhanced tolerance relative to the one or more parental plants to one or more stress conditions selected from unfavourable conditions relating to relative humidity, water availability, periodic drought, nutrients, sunlight, wind, temperature, pH, exogenous chemicals, chemical toxins such as salt, herbivory, prophylactic chemicals, fertilizers, pathogen attack such as bacterial, fungal, or virus infection and pest infestation. Also provided are plants, or precursor thereof, produced by the methods and assays for identifying a plant, or precursor thereof, produced by the methods.
The present invention relates to a method of identifying sets of DNA loci for identifying atypical growth conditions and for identifying the identity or source of cells of interest. The method can include identifying a plurality of sets of DNA loci that may identify a plurality of atypical growth conditions in cells of different origin and/or genotype. There is also provided sets of DNA loci and uses thereof.
A two colour fluorescent assay and a kit are described that permit the determination of live and dead parasitic or non-parasitic worms, for example helminths. The assay permits screening for the effect of one or more agents or an event on the viability of a parasitic or non-parasitic worm, In one example, the assay comprises (a) providing a sample comprising one or more parasitic or non-parasitic worms; (b) contacting the parasitic or non-parasitic worms with a concentration of fluorescein diacetate sufficient to yield detectable green fluorescence in any live parasitic or non-parasitic worms present in the sample and a concentration of propidium iodide sufficient to yield detectable red fluorescence in any dead parasitic or non-parasitic worms present in the sample; and (c) detecting the red and green fluorescence of the parasitic or non-parasitic worms. The assay further comprises contacting the parasitic or non-parasitic worms with one or more test agents, or subjecting the parasitic or non-parasitic worms to an event. The assay allows for a rapid and objective score of parasitic or non-parasitic worm death and survival and enables the performance of high- throughput screens for the identification of potential agents against diseases such as schistosomiasis. Also described are methods and kits for discriminatory analysis of parasitic or non-parasitic worm phenotype and/or metabolics using FTIR analysis.
Described are methods for analysing an animal carcass, meat obtained therefrom, or product produced by or obtained from an animal for the presence or absence of faecal matter. The methods comprise analysing an animal carcass, meat obtained therefrom, or product produced by or obtained from the animal for the presence or absence of a detectable marker, the presence of the detectable marker being indicative of the presence of faecal matter and the absence of the detectable marker being indicative of the absence of faecal matter, wherein the animal carcass, meat obtained therefrom, or product produced by or obtained from the animal has been obtained from an animal fed a composition comprising a supplement of the detectable marker and/or a precursor thereof. Also described are compositions for feeding to an animal and for use in the methods.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Education services; arranging and conducting conferences and
seminars; library services; publication of books, texts,
journals, magazines and periodicals; provision of
correspondence courses; provision of entertainment;
provision of cultural activities; provision of recreation
and sporting facilities.
41 - Education, entertainment, sporting and cultural services
Goods & Services
education services, namely, providing courses of instruction at the university level; arranging and conducting conferences and seminars in the fields of business, science, the arts, literature, and philosophy; libraries; publication of books, texts, journals, magazines and periodicals; education services, namely, provision of correspondence courses in the fields of business, science, the arts, literature, and philosophy; [ provision of entertainment, namely, live theatrical performances, providing motivational and educational speakers; ] provision of cultural activities, namely, organizing cultural events; provision of recreation and sporting facilities
There is provided the use of a sandalwood extract or a sandalwood analogue as an additive to animal foodstuff for the reduction of methane production, reduction of bacterial mediated protein breakdown and reduces bacterial growth in the stomach. There are also provided food products and methods of making food products incorporating sandalwood extracts or sandalwood analogues.
An imaging ellipsometer for imaging a substantially planar reflecting surface, the surface defining a surface plane. The ellipsometer comprises: a focussing element for focusing electromagnetic radiation specularly reflected from said surface, the focussing element having a focussing element plane; a detector for detecting specularly reflected electromagnetic radiation focussed by the focussing element at a detector plane; and a stage for supporting said surface; at least one constraining device for constraining the movement of the ellipsometer such that: the detector plane, the focussing element plane and said surface plane are arranged either to intersect along a single line or to be parallel to one another. Furthermore, the focussing element is arranged such that it is tiltable with respect to a principal axis such that the magnitude of an angle between a focussing element axis and the principal axis is able to be greater than 0 radians.
The present invention provides a method for detecting and/or quantifying the presence of, and relative abundance of, methylated nucleic acid bases within double- stranded nucleic acid by i) contacting a double-stranded nucleic acid sample with an intercalating fluorescent dye when bound to the nucleic acid sample fluoresces when exposed to light of a wavelength capable of causing the dye to fluoresce; 2) altering the hybridisation conditions of the solution containing the double-stranded nucleic acid-dye complex such that dissociation of the two strands of the said nucleic acid-dye complex occurs at a rate that permits progressive release of the dye 3) and monitoring the difference in fluorescence, and uses thereof.
The present invention relates to a method for determining the presence of Mycobacterium avium paratuberculosis in a subject. The method comprises: (i) determining the level of one or more metabolites in a sample from the subject; and (ii) comparing the level of said one or more metabolites with the level of said one or more metabolites in a control sample to determine whether Mycobacterium avium paratuberculosis is present in the subject. The metabolites are selected from: 2- hydroxyglutaric acid; leukotriene B4; itaconic acid; bicyclo-prostaglandin E2; N6-acetyl- L-lysine; guanidinobutanoic acid; creatine; docosahexaenoic acid; cis-10- nonadecenoic acid; creatinine; 5-hydroxyeicosapentaenoic acid, 17-hydroxy docosahexaenoic acid, palmitoleic acid; R-3-hydroxy-octadecanoic acid; 8,11,14- eicosatrienoic acid; nonadecanoic acid; stearic acid; eicosapentaenoic acid; 16- methylheptadecanoic acid; phytanic acid; arachidonic acid; 9,10-dihydroxy-12- octadecenoic acid, 8,11,14, 17-eicosatetraenoic acid; palmitic acid; pyruvic acid; and p- cresol.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
