This invention provides methods for optimal implantation of a solid substrate for promoting cell or tissue growth or restored function in an osteochondral, bone or cartilage tissue in a subject in need thereof. The methods include selecting and preparing a solid substrate for promoting cell or tissue growth or restored function for implantation, which solid substrate has a length and width or that promotes a tight fit within the boundaries of the implantation site and is further characterized by a height sufficient such that when a first terminus of said solid substrate is implanted within a bone in a site for implantation, a second terminus of said solid substrate is at a height at least 2 mm less than an articular cartilage layer surface or is proximal to a tide mark region in said implantation site and optionally applying a biocompatible polymer layer to an apical surface of said implant, which layer does not exceed the articular cartilage layer surface in height. Tools for implementation of optimal positioning are described including a unique tool (5-120) for trimming cartilage at the implantation site.
This invention provides, inter alia, a device having a cage having an opening or window in at least one of its walls that allows for the insertion of bone growth promoting materials therethrough, comprising one or more openings in one or more of the walls of the cage, designed to receive bone growth promoting materials, including coral-based materials, which facilitate in the fusion with the treated bone, and which optionally serves to reinforce the stability of the implanted structure. Methods of stabilizing two skeletal structures relative to one another, joining two skeletal structures which are discontinuous and repairing a ligament tear or replacing a ligament making use of a bone fusion device of the invention are described.
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
This invention provides optimized solid substrates for promoting cell or tissue growth or restored function, which solid substrate comprises aragonite and is characterized by a specific fluid uptake capacity value of at least 75%, or a contact angle value of less than 60 degrees when in contact with a fluid and which is further characterized by tapered sides and tools for implantation of optimized solid substrates.
This invention provides optimized solid substrates for promoting cell or tissue growth or restored function and uses of same, which in some aspects address a need in populations at greater risk for osteochondral, bone or cartilage disease, or in some embodiments, in subjects for whom no effective therapeutic or surgical intervention exists, or in some embodiments, in subjects for whom recovery from and/or quality of life after therapeutic intervention is not significantly improved, or not sustained over time, or a combination thereof. In some embodiments, the optimized solid substrates for promoting cell or tissue growth or restored function and uses of same, address a need in populations with therapeutic results significantly greater than the surgical standard of care. In some embodiments, the optimized solid substrates for promoting cell or tissue growth or restored function and uses of same, address treating or repairing a large osteochondral, bone or cartilage lesion site in a subject in need thereof.
This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which said substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.
This invention provides optimized solid substrates for promoting cell or tissue growth or restored function and uses of same, which in some aspects address a need in populations at greater risk for osteochondral, bone or cartilage disease, or in some embodiments, in subjects for whom no effective therapeutic or surgical intervention exists, or in some embodiments, in subjects for whom recovery from and/or quality of life after therapeutic intervention is not significantly improved, or not sustained over time, or a combination thereof. In some embodiments, the optimized solid substrates for promoting cell or tissue growth or restored function and uses of same, address a need in populations with therapeutic results significantly greater than the surgical standard of care. In some embodiments, the optimized solid substrates for promoting cell or tissue growth or restored function and uses of same, address treating or repairing a large osteochondral, bone or cartilage lesion site in a subject in need thereof.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
[ Retail and wholesale store services featuring pharmaceutical preparations, medicines, medical, surgical and dental apparatus and instruments ] Chemical, biochemical and biological substances for medical and veterinary purposes, namely, body and cartilage implants comprising living tissue; chemical preparations for pharmaceutical purposes, namely, for the treatment of genetic, cardiovascular, central nervous system, endocrine, gastrointestinal, hepatic, biliary, immunological, allergic, pulmonary, dermatological, infectious, inflammatory, menopausal, nutritional, metabolic, diabetes, autoimmune, musculoskeletal, bone, connective tissue, neurological, ophthalmologic, psychiatric, respiratory, urogenital, urological, erectile dysfunction, sexual dysfunction, gynecology, obstetric, pediatric, hematologic, oncological, fungal and viral diseases and disorders
9.
Optimized cage systems promoting bone repair and fusion
This invention provides, inter alia, a device having a cage having an opening or window in at least one of its walls that allows for the insertion of bone growth promoting materials therethrough, comprising one or more openings in one or more of the walls of the cage, designed to receive bone growth promoting materials, including coral-based materials, which facilitate in the fusion with the treated bone, and which optionally serves to reinforce the stability of the implanted structure. Methods of stabilizing two skeletal structures relative to one another, joining two skeletal structures which are discontinuous and repairing a ligament tear or replacing a ligament making use of a bone fusion device of the invention are described.
This invention provides coral-based scaffolds for cartilage repair, and instruments for insertion and utilization of same within a site of cartilage repair.
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which said substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.
This invention provides optimized solid substrates for promoting cell or tissue growth or restored function, which solid substrate comprises aragonite and is characterized by a specific fluid uptake capacity value of at least 75%, or a contact angle value of less than 60 degrees when in contact with a fluid and which is further characterized by tapered sides and tools for implantation of optimized solid substrates.
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
This invention provides methods for optimal implantation of a solid substrate for promoting cell or tissue growth or restored function in an osteochondral, bone or cartilage tissue in a subject in need thereof. The methods include selecting and preparing a solid substrate for promoting cell or tissue growth or restored function for implantation, which solid substrate has a length and width or that promotes a tight fit within the boundaries of the implantation site and is further characterized by a height sufficient such that when a first terminus of said solid substrate is implanted within a bone in a site for implantation, a second terminus of said solid substrate is at a height at least 2 mm less than an articular cartilage layer surface or is proximal to a tide mark region in said implantation site and optionally applying a biocompatible polymer layer to an apical surface of said implant, which layer does not exceed the articular cartilage layer surface in height. Tools for implementation of optimal positioning are described including a unique tool (5-120) for trimming cartilage at the implantation site.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Medical implants, namely, bone and cartilage implants made of biological materials; spinal implants made of biological materials Surgical apparatus and instruments for medical, dental or veterinary use; medical apparatus and instruments for use in transplantation; artificial limbs, eyes and teeth; orthopedic braces; orthopedic joint implants made of artificial materials; orthopedic inserts for shoes; supports for wrist, neck, back, ankle, knee and elbow for orthopedic medical use; splints; bone, joint, ankle, knee, elbow, leg and hand prostheses; surgical implants comprising artificial material; medical implants, namely, bone and cartilage implants made of artificial materials; spinal implants made of artificial materials; suture materials; replacement parts for the aforementioned goods
16.
Solid substrates for promoting cell and tissue growth
This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which said substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.
This invention provides, inter alia, a device having a cage having an opening or window in at least one of its walls that allows for the insertion of bone growth promoting materials therethrough, comprising one or more openings in one or more of the walls of the cage, designed to receive bone growth promoting materials, including coral-based materials, which facilitate in the fusion with the treated bone, and which optionally serves to reinforce the stability of the implanted structure. Methods of stabilizing two skeletal structures relative to one another, joining two skeletal structures which are discontinuous and repairing a ligament tear or replacing a ligament making use of a bone fusion device of the invention are described.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
35 - Advertising and business services
Goods & Services
Pharmaceutical preparations and substances for the treatment
of genetic, cardiovascular, central nervous system,
endocrine, gastrointestinal, hepatic, biliary,
immunological, allergic, pulmonary, dermatological,
infectious, inflammatory, menopausal, nutritional,
metabolic, diabetes, autoimmune, musculoskeletal, bone,
connective tissue, neurological, ophthalmologic,
psychiatric, respiratory, urogenital, urological, erectile
dysfunction, sexual dysfunction, gynecology, obstetric,
pediatric, hematologic, oncological, fungal and viral
diseases and disorders; veterinary preparations and
substances for the treatment of genetic, cardiovascular,
central nervous system, endocrine, gastrointestinal,
hepatic, biliary, immunological, allergic, pulmonary,
dermatological, infectious, inflammatory, menopausal,
nutritional, metabolic, diabetes, autoimmune,
musculoskeletal, bone, connective tissue, neurological,
ophthalmologic, psychiatric, respiratory, urogenital,
urological, erectile dysfunction, sexual dysfunction,
gynecology, obstetric, pediatric, hematologic, oncological,
fungal and viral diseases and disorders; medicines for the
treatment of genetic, cardiovascular, central nervous
system, endocrine, gastrointestinal, hepatic, biliary,
immunological, allergic, pulmonary, dermatological,
infectious, inflammatory, menopausal, nutritional,
metabolic, diabetes, autoimmune, musculoskeletal, bone,
connective tissue, neurological, ophthalmologic,
psychiatric, respiratory, urogenital, urological, erectile
dysfunction, sexual dysfunction, gynecology, obstetric,
pediatric, hematologic, oncological, fungal and viral
diseases and disorders; pharmaceutical preparations and
medicines for preventing transplant rejection; chemical,
biochemical and biological substances for medical and
veterinary purposes, namely, body and cartilage implants
comprising living tissue; sanitary preparations for medical
purposes; food for babies; dietary supplements for humans
and animals; nutritional supplements, vitamins, mineral
supplements; medical plasters, materials for dressings,
namely, gauze; medical adhesive tape, namely, dissolvable
strips to stop bleeding from minor cuts and grazes; material
for stopping teeth, dental wax; disinfectants for hygienic
purposes; chemical preparations for pharmaceutical purposes,
namely, for genetic, cardiovascular, central nervous system,
endocrine, gastrointestinal, hepatic, biliary,
immunological, allergic, pulmonary, dermatological,
infectious, inflammatory, menopausal, nutritional,
metabolic, diabetes, autoimmune, musculoskeletal, bone,
connective tissue, neurological, ophthalmologic,
psychiatric, respiratory, urogenital, urological, erectile
dysfunction, sexual dysfunction, gynecology, obstetric,
pediatric, hematologic, oncological, fungal and viral
diseases and disorders; diagnostic preparations for medical
use; diagnostic reagents for medicinal use; preparations for
destroying vermin; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and
instruments; artificial limbs, eyes and teeth; orthopedic
articles, namely braces, joint implants, shoe inserts,
wrist, neck, back, ankle, knee and elbow supporters,
protectors and splints; prosthesis; surgical implants;
medical implants, namely bone and cartilage implants; spinal
implants; suture materials; parts and accessories for the
aforementioned goods. Retail and wholesale services, namely, retail and wholesale
stores featuring pharmaceutical preparations, medicines,
medical, surgical and dental apparatus and instruments,
nutritional supplements, vitamins, mineral supplements;
advertising and business management services; business
management; providing office functions; import agencies;
sales promotion services; business consulting services;
business information services; public relations services;
electronic commerce services, namely, providing information
about products via telecommunication networks for
advertising and sales purposes; purchase and rental of
advertising space; direct mail advertising; business
networking; arranging of business introductions; conducting
of exhibitions for business purposes.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
35 - Advertising and business services
Goods & Services
Pharmaceutical preparations and substances for the treatment of genetic, cardiovascular, central nervous system, endocrine, gastrointestinal, hepatic, biliary, immunological, allergic, pulmonary, dermatological, infectious, inflammatory, menopausal, nutritional, metabolic, diabetes, autoimmune, musculoskeletal, bone, connective tissue, neurological, ophthalmologic, psychiatric, respiratory, urogenital, urological, erectile dysfunction, sexual dysfunction, gynecology, obstetric, pediatric, hematologic, oncological, fungal and viral diseases and disorders; veterinary preparations and substances for the treatment of genetic, cardiovascular, central nervous system, endocrine, gastrointestinal, hepatic, biliary, immunological, allergic, pulmonary, dermatological, infectious, inflammatory, menopausal, nutritional, metabolic, diabetes, autoimmune, musculoskeletal, bone, connective tissue, neurological, ophthalmologic, psychiatric, respiratory, urogenital, urological, erectile dysfunction, sexual dysfunction, gynecology, obstetric, pediatric, hematologic, oncological, fungal and viral diseases and disorders; medicines for the treatment of genetic, cardiovascular, central nervous system, endocrine, gastrointestinal, hepatic, biliary, immunological, allergic, pulmonary, dermatological, infectious, inflammatory, menopausal, nutritional, metabolic, diabetes, autoimmune, musculoskeletal, bone, connective tissue, neurological, ophthalmologic, psychiatric, respiratory, urogenital, urological, erectile dysfunction, sexual dysfunction, gynecology, obstetric, pediatric, hematologic, oncological, fungal and viral diseases and disorders; pharmaceutical preparations and medicines for preventing transplant rejection; chemical, biochemical and biological substances for medical and veterinary purposes, namely, body and cartilage implants comprising living tissue; sanitary preparations for medical purposes; food for babies; dietary supplements for humans and animals; nutritional supplements, vitamins, mineral supplements; medical plasters, materials for dressings, namely, gauze; medical adhesive tape, namely, dissolvable strips to stop bleeding from minor cuts and grazes; material for stopping teeth, dental wax; disinfectants for hygienic purposes; chemical preparations for pharmaceutical purposes, namely, for genetic, cardiovascular, central nervous system, endocrine, gastrointestinal, hepatic, biliary, immunological, allergic, pulmonary, dermatological, infectious, inflammatory, menopausal, nutritional, metabolic, diabetes, autoimmune, musculoskeletal, bone, connective tissue, neurological, ophthalmologic, psychiatric, respiratory, urogenital, urological, erectile dysfunction, sexual dysfunction, gynecology, obstetric, pediatric, hematologic, oncological, fungal and viral diseases and disorders; diagnostic preparations for medical use; diagnostic reagents for medicinal use; preparations for destroying vermin; fungicides, herbicides Surgical apparatus and instruments; medical, dental and veterinary apparatus and instruments for use in transplantation; artificial limbs, eyes and teeth; orthopedic articles, namely, braces, joint implants made from artificial materials, shoe inserts, wrist, neck, back, ankle, knee and elbow supports and splints; bone, joint, ankle, knee, elbow, leg and hand prostheses; surgical implants comprised of artificial materials; medical implants, namely, bone and cartilage implants comprised of artificial materials; spinal implants comprised of artificial materials; suture materials; replacement parts for the aforementioned goods Retail and wholesale services, namely, retail and wholesale stores featuring pharmaceutical preparations, medicines, medical, surgical and dental apparatus and instruments, nutritional supplements, vitamins, mineral supplements; advertising and business management services; business management; providing office functions; import agencies; sales promotion services; business consulting services; business information services; public relations services; electronic commerce services, namely, providing information about products via telecommunication networks for advertising and sales purposes; procuring of contracts for purchase of advertising space; rental of advertising space; direct mail advertising; business networking; arranging of business introductions; conducting of exhibitions for business purposes
21.
IMPLANTATION TOOL AND PROTOCOL FOR OPTIMIZED SOLID SUBSTRATES PROMOTING CELL AND TISSUE GROWTH
This invention provides methods for optimal implantation of a solid substrate for promoting cell or tissue growth or restored function in an osteochondral, bone or cartilage tissue in a subject in need thereof. The methods include selecting and preparing a solid substrate for promoting cell or tissue growth or restored function for implantation, which solid substrate has a length and width or that promotes a tight fit within the boundaries of the implantation site and is further characterized by a height sufficient such that when a first terminus of said solid substrate is implanted within a bone in a site for implantation, a second terminus of said solid substrate is at a height at least 2 mm less than an articular cartilage layer surface or is proximal to a tide mark region in said implantation site and optionally applying a biocompatible polymer layer to an apical surface of said implant, which layer does not exceed the articular cartilage layer surface in height. Tools for implementation of optimal positioning are described including a unique tool (5-120) for trimming cartilage at the implantation site.
This invention provides tools and kits for removal of a graft and/or for implantation of a solid or semi-solid form or graft within an appropriate desired tissue minimizing the potential for or actual breakage of the implant or graft during the stated process. Kits comprising such tools and methods making use of same are provided, as well.
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
medical implants, namely, bone and cartilage implants made of biological materials; spinal implants made of biological materials Surgical apparatus and instruments for medical, dental or veterinary use; medical apparatus and instruments for use in transplantation; artificial limbs, eyes and teeth; orthopedic braces; orthopedic joint implants made of artificial materials; orthopedic inserts for shoes; supports for wrist, neck, back, ankle, knee and elbow for orthopedic medical use; splints; bone, joint, ankle, knee, elbow, leg and hand prostheses; surgical implants comprising artificial material; medical implants, namely, bone and cartilage implants made of artificial materials; spinal implants made of artificial materials; suture materials; replacement parts for the aforementioned goods
25.
Optimized solid substrates, tools for use with same and uses thereof for promoting cell and tissue growth
This invention provides optimized solid substrates for promoting cell or tissue growth or restored function, which solid substrate comprises aragonite and is characterized by a specific fluid uptake capacity value of at least 75%, or a contact angle value of less than 60 degrees when in contact with a fluid and which is further characterized by tapered sides and tools for implantation of optimized solid substrates.
Surgical apparatus and instruments for medical, dental or veterinary use; medical apparatus and instruments for use in transplantation; artificial limbs, eyes and teeth; orthopedic braces; orthopedic joint implants made of artificial materials; orthopedic inserts for shoes; supports for wrist, neck, back, ankle, knee and elbow for orthopedic medical use; splints; bone, joint, ankle, knee, elbow, leg and hand prostheses; surgical implants comprising artificial material; medical implants, namely, bone and cartilage implants made of artificial materials; spinal implants made of artificial materials; suture materials; parts for the aforementioned goods
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Medical implants, namely, biological bone and cartilage implants made of living tissue [ ; biological spinal implants made of living tissue ] [ Surgical apparatus and instruments for medical, dental or veterinary use; medical apparatus and instruments for use in transplantation; artificial limbs, eyes and teeth; orthopedic braces; orthopedic joint implants made of artificial materials; orthopedic inserts for shoes; supports for wrist, neck, back, ankle, knee and elbow for orthopedic medical use; splints; bone, joint, ankle, knee, elbow, leg and hand prostheses; ] surgical implants comprising artificial material; medical implants, namely, bone and cartilage implants made of artificial materials [ ; spinal implants made of artificial materials; suture materials; replacement parts thereof for the aforementioned goods ]
Surgical, medical, dental and veterinary apparatus and
instruments: artificial limbs, eyes and teeth; orthopedic
articles, namely braces, joint implants, shoe inserts,
wrist, neck, back, ankle, knee and elbow supporters,
protectors and splints; prosthesis; surgical implants;
medical implants, namely bone and cartilage implants, spinal
implants; suture materials; parts and accessories for the
aforementioned goods.
29.
OPTIMIZED SOLID SUBSTRATES, TOOLS FOR USE WITH SAME AND USES THEREOF FOR PROMOTING CELL AND TISSUE GROWTH
[00520] This invention provides optimized solid substrates for promoting cell or tissue growth or restored function, which solid substrate comprises aragonite and is characterized by a specific fluid uptake capacity value of at least 75%, or a contact angle value of less than 60 degrees when in contact with a fluid and which is further characterized by tapered sides and tools for implantation of optimized solid substrates.
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
Surgical apparatus and instruments for medical, dental or veterinary use: artificial limbs, eyes and teeth; orthopedic braces, joint implants made of artificial materials, and shoe inserts; orthopedic supports for the wrist, neck, back, ankle, knee and elbow; orthopedic cushions and padding; splints; bone and joint prostheses; implants consisting of artificial materials; suture materials; parts for the aforementioned goods
32.
Solid substrates for promoting cell and tissue growth
This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.
This invention provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrates comprise a marine organism skeletal derivative and are characterized by a specific fluid uptake capacity value of less than 40%, processes for selection of the same and applications of the same. This invention also provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrates are characterized by having a contact angle value of more than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrate is characterized by a minimal surface roughness (Ra) or substantial surface smoothness, as measured by scanning electron microscopy or atomic force microscopy. The invention also provides processes for selection of an optimized coral-based solid substrate.
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
05 - Pharmaceutical, veterinary and sanitary products
35 - Advertising and business services
Goods & Services
Pharmaceutical preparations and substances; veterinary
preparations and substances; dental preparations and
substances; medicines; chemical, biochemical and biological
substances for medical and veterinary purposes; sanitary
preparations for medical purposes; dietetic food and
substances adapted for medical or veterinary use; food for
babies; dietary supplements for humans and animals;
nutritional supplements, vitamins, minerals; plasters,
materials for dressings; material for stopping teeth, dental
wax; disinfectants; chemical preparations for pharmaceutical
purposes; diagnostic preparations for medical use;
diagnostic reagents; preparations for destroying vermin;
fungicides, herbicides. Retail and wholesale services; store services; advertising
and management services; business management and operation;
office functions; import and trading services; sales
promotion services; business consulting services; business
information services; public relations services; electronic
commerce services; purchase and rental of advertising space;
direct mail advertising; arranging of business
introductions; conducting of exhibitions for business
purposes; data management services; operation and management
of customer services.
This invention is directed to aragonite and calcite hydrogel biomatrices, optionally seeded with precursor cells and uses thereof in tissue engineering, regeneration and repair, including in inducing or enhancing bone formation, cartilage formation or a combination thereof in a subject, and kits related thereto.
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
This invention provides aragonite- and calcite-based solid substrates for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which solid substrates comprise or are made to ultimately comprise three phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, and methods of use thereof.
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
This invention provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrate comprises a marine organism skeletal derivative and is characterized by a specific fluid uptake capacity value of less than 40%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value and processes for selection of an optimized marine organism skeletal derivative-based solid substrate for mitigating or preventing cell or tissue adherence and/or vascularization and applications of the same. This invention also provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrate is characterized by having a contact angle value of more than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for mitigating or preventing cell or tissue adherence and/or vascularization, which solid substrate is characterized by a minimal surface roughness (Ra) or substantial surface smoothness, as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for mitigating or preventing cell or tissue adherence and/or vascularization and applications of the same.
This invention provides tools and kits for removal of a graft and/or for implantation of a solid or semi-solid form or graft within an appropriate desired tissue minimizing the potential for or actual breakage of the implant or graft during the stated process. Kits comprising such tools and methods making use of same are provided, as well.
Surgical, medical, dental and veterinary apparatus and
instruments; artificial limbs, eyes and teeth; orthopedic
articles namely braces, joint implants, shoe inserts, wrist,
neck, back, ankle, knee and elbow supporters, protectors and
splints; prosthesis; surgical implants; medical implants,
namely bone and cartilage implants; spinal implants; suture
materials; parts and accessories for the aforementioned
goods.
This invention provides aragonite- and calcite-based solid substrates for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which solid substrates comprise or are made to ultimately comprise three phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, and methods of use thereof.
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
This invention provides coral-based scaffolds for cartilage repair, and instruments for insertion and utilization of same within a site of cartilage repair.
Surgical, medical, dental and veterinary apparatus and instruments; artificial limbs, eyes and teeth; Orthopedic articles, namely braces, joint implants, shoe inserts, wrist, neck, back, ankle, knee and elbow supporters, protectors and splints, prosthesis; Surgical implants comprising artifical material; medical implants, namely bone and cartilage implants; Spinal implants; Suture materials; Parts and accessories for the aforementioned goods; all aforementioned goods in class 10.
Surgical, medical, dental and veterinary apparatus and instruments; artificial limbs, eyes and teeth; Orthopedic articles, namely braces, joint implants, shoe inserts, wrist, neck, back, ankle, knee and elbow supporters, protectors and splints, prosthesis; surgical implants comprising artificial material; medical implants, namely bone and cartilage implants; spinal implants; suture materials; parts and accessories for the aforementioned goods; all aforementioned goods in class 10.
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
Surgical, medical, dental and veterinary apparatus and instruments; artificial limbs, eyes and teeth; orthopedic articles; medical implants; suture materials; parts and accessories for the aforementioned goods.
This invention provides coral-based scaffolds for cartilage repair, and instruments for insertion and utilization of same within a site of cartilage repair.
