Abstract

The present disclosure relates to a method, device, and system for automatically triaging and controlling a response. The method comprises the steps of: acquiring vitals information about a patient in question; extracting data for each item in the acquired vitals information about the patient; mapping the extracted data for each item to the corresponding item; calculating a severity response score corresponding to the risk level of the patient on the basis of the data for each item mapped to the corresponding item; setting a severity response scale based on the severity response score corresponding to the calculated risk level of the patient; and controlling so that the set severity response scale information is transmitted to at least one terminal and output.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 70/00 - ICT specially adapted for the handling or processing of medical references
• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation

Abstract

The present disclosure relates to an artificial intelligence-based device and method for providing guide information about rehabilitation exercise. The device comprises: a communication module for communication with an external device; a storage module for storing at least one process for providing guide information about rehabilitation exercise on the basis of artificial intelligence; and a control module for performing, on the basis of the at least one process, an operation for providing the guide information about rehabilitation exercise on the basis of artificial intelligence. The control module: collects medical data and a medical image, captured prior to surgery, of a corresponding patient on the basis of the storage module and a separate database; pre-processes the medical image and then inputs the pre-processed medical image to a first pre-trained model based on artificial intelligence to predict the probability that post-surgical complications will occur; and generates prediction information on the basis of the predicted result and provides the prediction information to a medical staff terminal.

IPC Classes  ?

• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• A63B 24/00 - Electric or electronic controls for exercising apparatus of groups
• G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition

Abstract

The present invention provides a system for interpolating an object by generating a viewpoint-transformed image, comprising: an image preparation unit that prepares a target viewpoint image and an auxiliary viewpoint image obtained by photographing the same object from different viewpoints; a viewpoint transformation unit that generates a viewpoint-transformed image by transforming the auxiliary viewpoint image to a viewpoint of the target viewpoint image; and an image matching unit that matches the target viewpoint image and the viewpoint-transformed image and interpolates the target viewpoint image by using the viewpoint-transformed image.

IPC Classes  ?

• G06T 3/4007 - Scaling of whole images or parts thereof, e.g. expanding or contracting based on interpolation, e.g. bilinear interpolation
• G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods

Abstract

[Method for reprogramming type 1 alveolar cells into type 2 alveolar cells using Rhosin] The present invention relates to a composition for inducing the reprogramming of type 1 alveolar cells into type 2 alveolar cells, the composition containing Rhosin as an active ingredient. According to the present invention, it is expected to be possible not only to reprogram AT1 cells into AT2 cells using Rhosin and thereby efficiently obtain AT2 cells which were previously difficult to obtain in sufficient numbers, but also to reprogram AT1 cells into AT2 cells in organoids while culturing the organoids themselves rather than culturing single cells, and thereby obtain cells having physiological activity more similar to that of actual tissue. [Method for reprogramming type 1 alveolar cells into type 2 alveolar cells using Dasatinib] The present invention relates to a composition for inducing the reprogramming of type 1 alveolar cells into type 2 alveolar cells, the composition containing Dasatinib as an active ingredient. According to the present invention, it is expected to be possible not only to reprogram AT1 cells into AT2 cells using Dasatinib and thereby efficiently obtain AT2 cells which were previously difficult to obtain in sufficient numbers, but also to reprogram AT1 cells into AT2 cells in organoids while culturing the organoids themselves rather than culturing single cells, and thereby obtain cells having physiological activity more similar to that of actual tissue. [Method for reprogramming type 1 alveolar cells into type 2 alveolar cells using ML141] The present invention relates to a composition for inducing the reprogramming of type 1 alveolar cells into type 2 alveolar cells, the composition containing ML141 as an active ingredient. According to the present invention, it is expected to be possible not only to reprogram AT1 cells into AT2 cells using ML141 and thereby efficiently obtain AT2 cells which were previously difficult to obtain in sufficient numbers, but also to reprogram AT1 cells into AT2 cells in organoids while culturing the organoids themselves rather than culturing single cells, and thereby obtain cells having physiological activity more similar to that of actual tissue. [ML141-containing composition for inhibiting lung cancer metastasis] The present invention relates to a composition for inhibiting lung cancer metastasis, the composition containing ML141 as an active ingredient. [Dasatinib-containing composition for inhibiting lung cancer metastasis] The present invention relates to a composition for inhibiting lung cancer metastasis, the composition containing Dasatinib as an active ingredient.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 35/00 - Antineoplastic agents
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 31/415 - 1,2-Diazoles
• A61P 35/04 - Antineoplastic agents specific for metastasis
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The present disclosure relates to an apparatus for providing augmented reality-based rehabilitation training, comprising: a communication unit that communicates with a terminal and a virtual reality apparatus; a storage unit storing one or more instructions for providing augmented reality-based rehabilitation training; and a processor that performs operations according to the instructions, wherein the processor may select a first target motion for rehabilitation training of a user on the basis of a rehabilitation part of the user, state information about the rehabilitation part, and a rehabilitation training schedule of the user, output, by means of the virtual reality apparatus, an image representing the selected first target motion, receive, by means of the communication unit, an image captured by the terminal, recognize, in the received image, a performance motion of the user following the first target motion, and evaluate the recognized performance motion.

IPC Classes  ?

• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G06T 19/00 - Manipulating 3D models or images for computer graphics
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06V 40/20 - Movements or behaviour, e.g. gesture recognition
• G06V 10/12 - Details of acquisition arrangementsConstructional details thereof
• G06V 20/64 - Three-dimensional objects
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects

Abstract

The present disclosure relates to a device and a method for automatically adjusting a paraffin block position of a tissue slicing device, the device including: a body unit; a block fixing unit for fixing a paraffin block and movably and rotatably installed with respect to the body unit; a cutting unit which is arranged on the lower side of the fixing unit in the body unit and on which a blade for cutting the paraffin block is mounted; an information acquisition unit for acquiring first information on the paraffin block fixed to the block fixing unit; and a processor for acquiring second information on a tissue within the paraffin block on the basis of the first information, determining a position and an angle for cutting the paraffin block on the basis of the second information, and controlling the operation of the block fixing unit on the basis of the determined position and angle.

IPC Classes  ?

• G01N 1/36 - Embedding or analogous mounting of samples
• G01N 1/28 - Preparing specimens for investigation
• G06V 10/10 - Image acquisition
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G06N 3/08 - Learning methods

Abstract

According to the present disclosure, an electronic device for preventing myopia by adjusting a display wavelength range according to time may comprise a camera, a display unit, and a processor electrically connected to the camera and the display unit so as to control operations, wherein the processor is configured to: identify a wavelength range for at least a part of the display unit; sense information related to an external environment of the electronic device via the camera; and on the basis of the information related to the external environment, control the wavelength range for the at least a part of the display unit so as to adjust a wavelength range provided to a user of the electronic device via the at least a part of the display unit.

IPC Classes  ?

• G09G 3/32 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED]
• G09G 5/10 - Intensity circuits
• G09G 3/20 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix

Abstract

The present invention relates to an immunomodulatory therapeutic composition for immunomodulation through the transplantation of induced pluripotent stem cell (iPSC)-derived mitochondria. The iPSC-derived mitochondria according to the present invention overexpress UCP2, and the expression of UCP2 was found to be associated with an immunomodulatory effect. In addition, the administration of iPSC-derived mitochondria was found to enhance mitochondrial function and thereby increase ATP synthesis and mitochondrial membrane potential. In addition, the present invention was found to regulate the expression of autoimmune disease-related immune cells and to increase the synergistic effect of immune cell regulation when used in combination with metformin. In addition, the present invention was found to reduce the activity of autoimmune disease symptoms and inhibit cell expression related to autoimmunity. In addition, treating peripheral blood mononuclear cells with iPSC-derived mitochondria was found to inhibit Th17 expression and increase Treg expression, as well as improve immunomodulation and ameliorate the pathological activity of various immune diseases.

IPC Classes  ?

• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells
• A61P 37/00 - Drugs for immunological or allergic disorders
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

A method for distinguishing between types of thyrotoxicosis including Graves' disease, autoimmune thyroiditis, and subacute thyroiditis on the basis of machine learning according to an embodiment of the present invention comprises the steps of: acquiring a basic ultrasound image (gray scale), a color Doppler image, and a power Doppler image of the thyroid of a diagnosis subject; and determining whether the diagnosis subject corresponds to one of Graves' disease, autoimmune thyroiditis, or subacute thyroiditis by using a machine-learning model trained to distinguish between types of thyrotoxicosis on the basis of basic ultrasound images, color Doppler images, and power Doppler images of the thyroids of each of Graves' disease, autoimmune thyroiditis, and subacute thyroiditis patients.

IPC Classes  ?

• A61B 8/08 - Clinical applications
• A61B 8/06 - Measuring blood flow
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G06N 20/00 - Machine learning

Abstract

The present invention relates to a crutch for fixing to a shoulder, the crutch comprising: a main body that supports a user's shoulder and assists the user in walking according to manipulations by the user; a fixing strap that is provided on the main body and worn around the circumference of the user's shoulder; a cut portion cut into a region of the fixing strap; and a detachment portion that detachably couples one side and the other side of the fixing strap adjacent to the cut portion.

IPC Classes  ?

• A61H 3/02 - Crutches
• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about
• A44B 11/00 - BucklesSimilar fasteners for interconnecting straps or the like, e.g. for safety belts

Abstract

An apparatus and a method for predicting re-rupture of a tendon based an artificial intelligence (AI) are provided. The apparatus includes a communication module to make communication with an external device, an acquiring module to acquire at least one arthroscopic image including a surgical portion of a patient experiencing a surgery, a storage module to store at least one process based on the AI, and a control module to perform an operation for predicting the re-rupture of the tendon based on the AI, through the at least one process. The control module performs a pre-processing operation for the at least one arthroscopic image, predicts a probability of the re-rupture of the tendon by inputting the at least one arthroscopic image, which is pre-processed, into a pre-trained model based on the AI, and generates prediction information for the patient based on a prediction result.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06T 7/00 - Image analysis

Abstract

An embodiment provides a method for measuring a femoral anterior angle and a tibial torsion angle by using artificial intelligence, the method comprising the steps of: (a) obtaining, by a CT scanner, 2D CT images of the femur, the tibia, and the malleolus of a patient; (b) storing, in a big-data unit, the 2D CT images transmitted from the CT scanner; (c) setting, by an artificial intelligence unit, a first baseline related to the femoral head and neck, a second baseline related to the lower femoral, a third baseline related to the upper tibial, and a fourth baseline related to the malleolus, on the basis of the 2D CT images; and (d) measuring, by an angle measurement unit, a femoral anterior angle formed between the first baseline and the second baseline, and a tibial torsion angle formed between the third baseline and the fourth baseline.

IPC Classes  ?

• A61B 6/03 - Computed tomography [CT]
• A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications

Abstract

According to an embodiment of the present disclosure, disclosed are an eye drop storage device for assisting a user to use an eye drop and a method for operating the eye drop storage device. The eye drop storage device may comprise: a body; an eye drop support unit connected to the body and accommodating an eye drop container; a detection sensor connected to the body and obtaining a user input for opening or closing a lid of the eye drop container; an eye drop opening and closing unit connected to the body; and at least one processor, wherein at least one processor opens or closes the lid of the eye drop container on the basis of the user input through the eye drop opening and closing unit.

IPC Classes  ?

• A61J 1/16 - Holders for containers
• A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
• A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes DetailsAccessories therefor
• A61J 1/18 - Arrangements for indicating condition of container contents, e.g. sterile condition
• A61J 7/04 - Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
• A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
• G16H 20/13 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers

Abstract

An electronic device to which a machine learning ensemble model is applicable, according to an exemplary embodiment of the present disclosure, may comprise: a first model neural-network-trained on the basis of training images; a second model trained on the basis of training test data; a third model using voting based on a plurality of statistical methodologies so as to output the infection probability of malaria infection; and a processor, which inputs, into the first model, a blood image to be tested, uses the first model to make a primary determination of malaria infection about the blood image, inputs, into the second model, blood data to be tested, uses the second model to make a secondary determination of malaria infection about the blood data, and uses the third model to output the malaria infection probability.

IPC Classes  ?

• G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G06N 20/20 - Ensemble learning
• G06T 7/00 - Image analysis
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to a polynomial curve design technology and, more specifically, to an apparatus and a method for designing a polynomial curve by using a hodograph control polygon. According to an embodiment of the present invention, even when the order of the polynomial curve increases, the shape of the curve can be easily predicted. In addition, the shape of the curve can be adjusted by moving the position of a control point, and simultaneously, a tangent vector at a specific point on the curve can be controlled through each side of the hodograph control polygon, whereby the shape of the polynomial curve can be easily adjusted. Since the sum of the lengths of respective sides of the hodograph control polygon corresponds to a numerical integral of a speed function of the polynomial curve, the hodograph control polygon and the curve have similar lengths, and thus the shape and length can be simultaneously controlled when the polynomial curve is designed.

IPC Classes  ?

• G06T 11/20 - Drawing from basic elements, e.g. lines or circles
• G06T 17/30 - Surface description, e.g. polynomial surface description

Abstract

A processing method using a surgical guide, in relation to an example of the present invention, may comprise: a first step of obtaining at least one medical image among a CT image and an MRI image; a second step of pre-processing the at least one medical image and segmenting same into the humerus head of the humerus and other structures; a third step of generating a three-dimensional (3D) digital structure model for a shoulder joint of a patient by using the segmented image; a fourth step of establishing, on the basis of the digital structure model, a virtual plan for determining a resection surface for the humeral head; a fifth step of generating, on the basis of information about the resection surface determined in the virtual plan, design information for manufacturing the surgical guide; and a sixth step of generating the surgical guide by means of 3D printing technology using the design information.

IPC Classes  ?

• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• G06T 17/00 - 3D modelling for computer graphics
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The method for generating a deep learning-based surgery plan, related to an embodiment of the present invention may include: a first step of acquiring X-ray image information; a second step of performing preprocessing for analysis of a predetermined region of the X-ray image information; a third step of analyzing the preprocessed X-ray image by using a convolutional neural network and extracting feature information from the result of the analysis and learning same; a fourth step of repeating the first step to the third step and generating template data for the predetermined region, on the basis of the repeatedly learned feature information; a fifth step of obtaining first X-ray image information of a user; a sixth step of extracting first feature information related to the user from the feature information by using the first X-ray image information and the template data; and a seventh step of generating a surgery plan related to the user, on the basis of the first feature information.

IPC Classes  ?

• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]

Abstract

The present invention relates to an eyelid speculum comprising: a frame; a first rotary arm rotatably coupled to one side of the frame; a second rotary arm rotatably coupled to the other side of the frame; a moving part for moving the first rotary arm and the second rotary arm in the direction of moving closer to each other or in the direction of moving away from each other; a first support arm rotatably coupled to the first rotary arm so as to support the upper eyelid; and a second support arm rotatably coupled to the second rotary arm so as to support the lower eyelid.

IPC Classes  ?

• A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors

Abstract

The present disclosure relates to a fomentation assistance apparatus comprising: a communication module that receives affected part data from a user terminal; a memory storing the affected part data; a fomentation module that performs a fomentation assistance operation including a cold fomentation operation and a hot fomentation operation; and a control module that controls the fomentation assistance operation on the basis of the affected part data, wherein the affected part data may include at least one of the time of injury, the type of affected part, and the degree of injury.

IPC Classes  ?

• A61F 7/02 - Compresses or poultices for effecting heating or cooling
• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body

Abstract

Provided is an immunomodulatory treatment composition for a transplantation disease through combined administration of a microbiome and an immunosuppressant. According to the present disclosure, it was confirmed that in an allogeneic transplantation cell model, combined administration of FK506 and the microbiome suppressed alloresponse and regulated the activity of T cells and B cells. Further, it was confirmed that in an acute graft-versus-host disease animal model, the combined administration reduced the disease activity, increased the probability of survival, and protected the tissue damage. In addition, it was confirmed that the combined administration improved transplantation rejection diseases by reducing the activity of Th1 and Th17 and increasing the activity of Tregs, and thus can be usefully used as an immunomodulator for transplantation rejection.

IPC Classes  ?

• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• A61P 37/04 - Immunostimulants

Abstract

The present invention relates to a chair having safety belts, the chair comprising: a chair body having a seat plate, on which an occupant sits, and a backrest, which is coupled to the seat plate and supports the back of the occupant; and safety belts which are detachably connected to the backrest and worn on the upper body of the occupant, wherein the safety belts generate elastic force that presses the upper body of the occupant against the backrest and extends the waist of the occupant.

IPC Classes  ?

• A47C 7/62 - Accessories for chairs
• A47C 7/40 - Supports for the head or the back for the back
• A44B 11/00 - BucklesSimilar fasteners for interconnecting straps or the like, e.g. for safety belts

Abstract

The present invention relates to a chair having an abdominal support band function, the chair comprising: a chair body including a seat on which a sitter is seated and a backrest which is coupled to the seat and supports the back of the sitter; and a wearing part which is detachably coupled to the backrest, is worn on the upper body of the sitter, and generates an elastic force for bringing the upper body of the sitter into close contact with the backrest to cause the sitter to straighten himself/herself.

IPC Classes  ?

• A47C 7/46 - Supports for the head or the back for the back with special, e.g. adjustable, profile"Ackerblom" profile chairs
• A47C 31/02 - Upholstery attaching means

Abstract

A device and method for predicting a pathologic fracture in the proximal femur are disclosed. The device for predicting a pathologic fracture in the proximal femur according to an aspect of the present invention is a device for predicting a pathologic fracture in the proximal femur of an advanced cancer patient, including: a memory for storing one or more instructions; and a processor for executing the one or more instructions, wherein the processor can process a CT image including the femur of the cancer patient to generate an input image by executing the one or more instructions, input the input image into a fracture prediction artificial neural network model, and obtain prediction information about whether a pathologic fracture in the proximal femur will occur within a predetermined period from the time of acquiring the CT image which is output by the fracture prediction artificial neural network model.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G06T 7/00 - Image analysis
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating autosomal dominant polycystic kidney diseases. When the cetirizine and L-5-hydroxytryptophan according to the present invention are administered alone or in combination, cyst formation is inhibited in an autosomal dominant polycystic kidney disease model induced by PKD1 or PKD2 gene mutation. Therefore, the cetirizine or L-5-hydroxytryptophan according to the present invention is expected to be advantageously used as a therapeutic agent for autosomal dominant polycystic kidney diseases.

IPC Classes  ?

• A61K 31/4965 - Non-condensed pyrazines
• A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A device for inserting a chest tube for thoracoscopy comprises a photographing module that photographs an inside of a subject's body and transmits a photographed in-vivo image to an outside; a chest tube that is formed in a rigid tube shape and in which the photographing module is inserted and installed; a guide part that is coupled to the photographing module and guides the photographing module into the chest tube; a handle module that is coupled to the guide part and moves the guide part and photographing module; and a mobile device that receives data from the photographing module, and searches for and reproduces the in-vivo image photographed by the photographing module in real time.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
• A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems

Abstract

Provided according to the present invention is a viewing distance measurement apparatus using an infrared distance measurement sensor, the viewing distance measurement apparatus comprising: a main body having a front frame and a pair of side frames connected to both sides of the front frame; a gaze tracking unit that is coupled to the center of the front frame and tracks the gaze of a user to generate gaze tracking information; a distance measurement unit that is located adjacent to the gaze tracking unit and generates distance measurement information with respect to a subject being watched by the user; a data management unit that is coupled to the bottom of one side frame of the pair of side frames, receives the gaze tracking information from the gaze tracking unit, and receives the distance measurement information from the distance measurement unit; and a battery unit coupled to the bottom of the other side frame of the pair of side frames.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
• A61B 3/14 - Arrangements specially adapted for eye photography
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes

Abstract

Disclosed are a smart eye patch utilizing the Internet of Things, and a method and a system for controlling the operation thereof. A terminal communicating with a smart eye patch including at least one light-emitting unit and sensor according to the present disclosure may comprise: a communication module; a display; a reception unit for receiving a signal from the smart eye patch; an analysis unit for processing and analyzing the received signal from the smart eye patch; and a control unit for controlling the operation of the smart eye patch according to the content analyzed by the analysis unit.

IPC Classes  ?

• A61F 9/04 - Eye-masks
• G16Y 40/10 - DetectionMonitoring
• G16Y 10/60 - HealthcareWelfare
• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

A device and method for extracting a plurality of tile images from specimen cytology slide images divided according to a cell staining method, and classifying a class of at least one of a type of cancer and whether there is cancer according to a cell staining method in any specimen cytology slide image using a prediction model that has undergone annotation-based learning on the specimen cytology slide images or the tile images.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• B01L 9/00 - Supporting devicesHolding devices
• G01N 1/30 - StainingImpregnating
• G01N 1/31 - Apparatus therefor
• G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
• G16B 40/20 - Supervised data analysis

Abstract

The present invention relates to a method for predicting survival of non-small cell lung cancer patients with brain metastasis. More specifically, it proposes a method that is useful for predicting the survival of the patients by comparing TMTrg of the patients with cut off value for predicting long term survival.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

The present disclosure relates to a virtual autopsy detection device and method, which may: receive a two-dimensional image; preprocess the received two-dimensional image; learn the preprocessed two-dimensional image; generate a three-dimensional image and result data on the basis of the learned two-dimensional image; divide the generated three-dimensional image into a plurality of three-dimensional images; and display the plurality of divided three-dimensional images and the result data.

IPC Classes  ?

• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61B 16/00 - Devices specially adapted for vivisection or autopsy
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS

Abstract

The present invention relates to a method of developing a tissue-specific vascular endothelial cell line based on iPSCs derived from human tissue-specific cells. When an organoid is manufactured using the cell line based on the iPSCs derived from human tissue-specific cells, the organoid manufacturing period may be significantly shortened, thereby solving the problem of sustainability, which is a major drawback known in the related art, and may be stored conveniently, and thus may be easily used during each experiment, thereby greatly increasing efficiency. Also, the organoid manufactured from the cell line of the present invention may be usefully used in the manufacture of blood vessel organoids in that the organoid is not only tissue-specific but also exhibits an excellent level of morphological and functional maturity.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

The present disclosure relates to a braille recognition band, and an operation method and system therefor. The method includes the steps of: confirming whether a braille recognition band is activated; outputting an alarm signal when the braille recognition band is activated; transmitting a first signal to a terminal; obtaining braille sensing data; and transmitting a second signal to the terminal.

IPC Classes  ?

• G09B 21/00 - Teaching, or communicating with, the blind, deaf or mute
• G06F 1/16 - Constructional details or arrangements
• G06F 3/16 - Sound inputSound output
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06V 30/142 - Image acquisition using hand-held instrumentsConstructional details of the instruments
• G06V 30/41 - Analysis of document content
• G10L 13/08 - Text analysis or generation of parameters for speech synthesis out of text, e.g. grapheme to phoneme translation, prosody generation or stress or intonation determination
• G10L 15/26 - Speech to text systems

Abstract

The present invention relates to a composition for diagnosing limb-girdle muscular dystrophy type 2H, a method of providing information for diagnosis, and a method of screening a drug for the treatment of limb-girdle muscular dystrophy type 2H.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a method for analyzing the risk of developing normal tension glaucoma in Koreans by a single nucleotide polymorphism (SNP) and, more specifically, relates to: a method for identifying, from a biological sample, one or more SNPs selected from the group consisting of rs10483727 and rs33912345; a biomarker composition for detecting normal tension glaucoma in Koreans, comprising an SNP; a composition for predicting the risk of developing normal tension glaucoma, comprising an agent capable of detecting the biomarker composition; and a kit for predicting the risk of developing normal tension glaucoma, comprising the composition. According to the present invention, it is possible to provide information useful for predicting the risk of developing normal tension glaucoma in Koreans on the basis of SNPs. In particular, such information can be more conveniently provided by using the kit of the present invention.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism

Abstract

Embodiments of the present disclosure relate to a tray device for a closed mouth impression for obtaining horizontal/vertical intermaxillary relations, which can significantly reduce the number of patient visits and a denture fabrication schedule by accurately recording the oral environment of a patient with a single impression. The tray device for a closed mouth impression for obtaining horizontal/vertical intermaxillary relations, according to the present embodiments, comprises one or both of an upper jaw tray and a lower jaw tray, wherein the upper jaw tray has support members that protrude by a predetermined height from the anterior teeth portion and the posterior teeth portions at either side, the lower jaw tray has support members that protrude by a predetermined height from the anterior teeth portion and the posterior teeth portions at either side, and both the upper jaw tray and the lower jaw tray are provided with a plurality of capping members that can be coupled to the support members formed at the three locations.

IPC Classes  ?

• A61C 9/00 - Impression methods specially adapted for dental prostheticsImpression cups therefor
• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereonDental implantsImplanting tools

Abstract

The present invention relates to a device for fixing a microscope slide, the device comprising: a base that can be detachably coupled to a stage on which the slide is disposed; a support unit which is connected to one side of the base and supports one side of the slide; a rotation unit which is rotatably coupled to the other side of the base and is rotated toward the support unit to press and fix the other side of the slide; and a first protection unit which is provided in the rotation unit and reduces the friction between the rotation unit and the other side of the slide.

IPC Classes  ?

• G02B 21/26 - StagesAdjusting means therefor
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G02B 21/34 - Microscope slides, e.g. mounting specimens on microscope slides

Abstract

The method for performing endoscopic examination according to an exemplary embodiment of the present invention may include the steps of obtaining an endoscopic image and a 3D model of a target organ; identifying location information of an endoscope on the 3D model in real time based on simultaneous localization and mapping (SLAM); classifying a plurality of areas constituting the 3D model into examination areas and unexamined areas by using the endoscopic image and the location information; and providing feedback information based on the examination areas and unexamined areas.

IPC Classes  ?

• G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
• G06T 7/579 - Depth or shape recovery from multiple images from motion
• G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects

Abstract

A brain protection pad is disclosed. A brain protection pad, according to one embodiment of the present invention, comprises an artificial dura mater layer configured to cover the brain exposed to the outside after a craniotomy. The artificial dura mater layer comprises artificial dura mater having a predetermined area so as to cover the brain, and may comprise one or more from among incision portions formed by partially incising the artificial dura mater so as to enable the artificial dura mater to expand in a direction perpendicular to the incision direction, and corrugations formed by folding the artificial dura mater so as to enable the artificial dura mater to expand in an unfolding direction.

IPC Classes  ?

• A61F 13/12 - Bandages or dressingsAbsorbent pads specially adapted for the head or neck

Abstract

The present invention relates to an auxiliary device worn in the oral cavity and includes: a first wearing part formed so as to be bitten by the teeth on either the left or right side; and a swallowing prevention part bent and extending from the front end portion and located on the palate side when the auxiliary device is worn. Accordingly, the auxiliary device prevents swallowing accidents during dental treatments, thus ensuring the safety of patients, and supports the use of suction equipment and can thus assist a doctor in treatment.

IPC Classes  ?

• A61C 19/00 - Dental auxiliary appliances
• A61C 5/80 - Dental aids fixed to teeth during treatment, e.g. tooth clamps
• A61C 17/02 - Rinsing or air-blowing devices, e.g. using fluid jets

Abstract

The present invention provides an oral scanner cover comprising: a body part, coupled to the portion of the tip of an oral scanner where a window is formed, and including a top surface part supported on the upper surface of the tip and a left surface part and a right surface part supported on the left surface and the right surface of the tip, respectively; and a pair of shielding parts extending downward from the left surface part and the right surface part and positioned at the respective sides of the window.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present disclosure relates to an injection system for regulating the injecting of a material into a lung sample on the basis of artificial intelligence, and a method using same, the present injection system comprising: an injection device for injecting a material into a first sample which is a lung sample corresponding to a specific patient; a camera for photographing material injection states of second samples which are a plurality of lung samples corresponding to various patients; and a server configured to, on the basis of artificial intelligence, analyze and model images of the material injection states of the second samples acquired through the camera. The injection device comprises: a filler tank containing the material which is injected into the first sample; a pressure gauge for measuring the pressure at which the material is injected into the first sample; a pressure regulator for regulating the pressure at which the material is injected into the first sample; and a processor. The processor may be configured to check the pressure measured through the pressure gauge and regulate the checked pressure through the pressure regulator on the basis of an adequate material injection state acquired from the server.

IPC Classes  ?

• A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06N 3/09 - Supervised learning
• A61M 5/142 - Pressure infusion, e.g. using pumps

Abstract

Disclosed are an ultrasonic ocular surgery warning device using an ultrasonic sensor and a method thereof. The ultrasonic ocular surgery alarm device according to an embodiment of the present invention includes: an ultrasonic sensor, provided at one end of an ocular surgery device, for measuring the distance from a first point on an eyeball; and a processor that outputs a notification on the basis of the distance, from the first point to the ultrasonic sensor, transmitted from the ultrasonic sensor. The processor compares the distance, from the first point to the ultrasonic sensor, transmitted from the ultrasonic sensor with a notification reference, and outputs a distance-dependent notification according to the comparison result, differentially outputting the notification according to the identified distance from the first point to the ultrasonic sensor.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery
• G08B 21/02 - Alarms for ensuring the safety of persons

Abstract

The present invention relates to extramammary Paget disease biomarkers, such as SPDEF, ARG2, and ABEP1, and uses thereof that were discovered by exploring the molecular profile as well as performing a comprehensive genetic analysis of EMPD. The present invention investigates how EMPD evolves in the context of treatment and may elucidate a potential mechanism of progression to invasion. Furthermore, the biomarkers of the present invention may be usefully used in the diagnosis or treatment of extramammary Paget disease in that the tissue microenvironments and cell types associated with EMPD may be further characterized using spatial transcriptomics.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Disclosed is a pharmaceutical composition for preventing or treating colon cancer comprising extracellular vesicles loaded with an MACC1 inhibitor as an active ingredient. The pharmaceutical composition allows the extracellular vesicles loaded with the MACC1 inhibitor, a colon cancer-promoting factor, to deliver the inhibitor specifically to colon cancer cells and is characterized by high stability and biodegradability, thereby having a low risk of side effects and excellent drug delivery. Therefore, the pharmaceutical composition of the present disclosure is expected to be utilized in a variety of ways as a treatment for colon cancer with minimal risk of side effects and maximized anticancer ability.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/50 - Microcapsules
• A61P 35/00 - Antineoplastic agents

Abstract

Provided according to embodiments of the present invention is an apparatus and method for the prognosis of elderly depression patients, the apparatus comprises: a preprocessing unit for preprocessing brain imaging biomarkers of elderly depression patients; and a prediction unit for predicting a therapeutic effect of an anti-depressive drug in any given elderly depression patient for the brain imaging biomarkers and blood biomarkers or the drug administration effect evaluation results, through the pre-processed brain imaging biomarkers and blood biomarkers or drug administration effect evaluation results together with a prognosis prediction model trained to predict the effectiveness of antidepressant treatment in elderly depression patients by using the pre-processed brain imaging biomarkers and blood biomarkers.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

The present invention relates to a composition comprising human allogeneic dermal powder and platelet-rich plasma for treating musculoskeletal diseases, and a method for preparing same. The composition is administered to patients with musculoskeletal diseases so as to improve functions and alleviate pain, reduce the size of ruptured tendons and induce structural regeneration of tendons, and thus can be effectively used as a pharmaceutical composition for preventing or treating musculoskeletal diseases.

IPC Classes  ?

• A61K 35/36 - SkinHairNailsSebaceous glandsCerumenEpidermisEpithelial cellsKeratinocytesLangerhans cellsEctodermal cells
• A61K 35/16 - Blood plasmaBlood serum
• A61K 35/19 - PlateletsMegacaryocytes
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

The method for preventing or treating of cancer includes administering a pharmaceutical composition to a subject in need thereof comprising a compound represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof as an active ingredient. The method for preventing or treating of cancer includes administering a pharmaceutical composition to a subject in need thereof comprising a compound represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof as an active ingredient. The method for preventing or treating of cancer includes administering a pharmaceutical composition to a subject in need thereof comprising a compound represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof as an active ingredient. wherein the composition inhibits the growth of cancer cells.

IPC Classes  ?

• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 35/74 - Bacteria
• A61P 35/00 - Antineoplastic agents
• A61P 37/04 - Immunostimulants

Abstract

Disclosed is a method of producing vascularized respiratory (airway and alveolar) organoids using blood vessel organoids. More particularly, vascularized respiratory (airway and alveolar) organoids with a vascular network are produced by fusing respiratory (airway and alveolar) organoids with blood vessel organoids to induce vascularization. The vascularized respiratory (airway and alveolar) organoids can have functions very similar to the human respiratory whole region, so they are expected to be transplanted into humans to treat respiratory related diseases or be used as an in vitro respiratory whole region model.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

A tumor classification method using multi-wavelength photoacoustic image and ultrasound image comprises the steps of: receiving, by an analysis device, an image set including photoacoustic frames and ultrasound frames collected over time for a predetermined period of time by each of a plurality of wavelength bands with respect to a subject; selecting, by the analysis device, photoacoustic frames and ultrasound frames to be analyzed, from the image set, on the basis of ultrasound image; performing, by the analysis device, spectral unmixing analysis on the selected photoacoustic frames; calculating, by the analysis device, at least one parameter for a tumor region by using the result of the spectral unmixing analysis; and classifying, by the analysis device, the subject's tumor by using the parameter.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to targeted extracellular vesicles and, more specifically, to targeted exosomes in which exosomes that target CD133, which is a cancer stem cell receptor in metastatic pancreatic cancer, are encapsulated with siRNA that inhibits the expression of PDL-1, which is an immune checkpoint receptor. Transgenic mammalian cells into which a recombinant vector of the present invention is introduced can produce exosomes with excellent targeting performance, in which a CD133-targeting peptide is expressed along with a transmembrane domain, and thus, a large amount of the CD133-targeting peptide is loaded on the surface thereof, and it was experimentally verified and confirmed that the targeted exosomes in which exosomes are encapsulated with siRNA that inhibits the expression of PDL-1, which is an immune checkpoint receptor, exhibited excellent antitumor and antimetastatic effects in pancreatic cancer cell lines and pancreatic cancer metastatic mouse models. Therefore, the exosomes that target CD133, which are encapsulated with siRNA that inhibits the expression of PDL-1, of the present invention, can be developed as an active ingredient of a pharmaceutical composition for the treatment of various types of cancer in which a CD133 receptor is expressed.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

A device, method and system for optimizing pathological slide encapsulant dispensing on the basis of artificial intelligence are disclosed. A pathological slide rapid drying device for digital pathology, according to at least one of various embodiments of the present disclosure, may comprise: a drying die having a pathological slide arranged thereon; a drying device; and a controller which calculates drying optimization conditions for the pathological slide arranged on the drying die, and which inputs the calculated drying optimization conditions into the drying device so as to control, through the drying device, rapid drying of the pathological slide arranged on the drying die.

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• F26B 21/00 - Arrangements for supplying or controlling air or gases for drying solid materials or objects
• F26B 3/28 - Drying solid materials or objects by processes involving the application of heat by radiation, e.g. from the sun
• F26B 21/06 - Controlling, e.g. regulating, parameters of gas supply

Abstract

An ingrown fingernail/toenail correction device using a shape memory alloy, includes a first fixing part configured to be fixed to an ingrown fingernail/toenail, a second fixing part configured to be fixed to the ingrown fingernail/toenail and spaced apart from the first fixing part at a predetermined distance, and a correction part inserted into the first fixing part and the second fixing part and made of a shape memory alloy so that when the correction part reaches a preset temperature, a shape of the correction part returns to a preset shape to provide a corrective force to the first fixing part and the second fixing part.

IPC Classes  ?

• A61F 5/11 - Devices for correcting deformities of the nails

Abstract

Disclosed are a device, method, and system for optimizing the dispensing of encapsulants onto pathological slides on the basis of artificial intelligence. The device for optimizing the dispensing of encapsulants onto pathological slides on the basis of artificial intelligence according to the present disclosure comprises: a memory storing at least one process for optimizing the dispensing of encapsulants onto the pathological slides; and a processor for performing an operation for optimizing the dispensing of the encapsulants onto the pathological slides according to the process. The processor may: acquire an image by scanning a paraffin section for a specimen on a target pathological slide; acquire information about the paraffin section on the basis of the acquired image on the basis of artificial intelligence; determine an optimal encapsulant dispensation amount and speed for the target pathological slide; and control the dispensing of the encapsulant onto the target pathological slide according to the determined optimal encapsulant dispensation amount and speed.

IPC Classes  ?

• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor

Abstract

According to present embodiments, provided are a device for predicting prognosis of elderly depression patients and a method therefor, the device comprising: a preprocessing unit for preprocessing neuroimaging biomarkers of an elderly depression patient; and a prediction unit for predicting the elderly-depression-patient-therapeutic effect of antidepressants on neuroimaging biomarkers and blood biomarkers in a random elderly depression patient, through a prognosis prediction model for elderly depression patients, which has been trained to predict antidepressant therapeutic effects in elderly depression patients by using preprocessed neuroimaging biomarkers and blood biomarkers.

IPC Classes  ?

• G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods
• A61B 5/16 - Devices for psychotechnicsTesting reaction times
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

A system for determining a sputum type using a respiratory sound according to an embodiment may comprise a data collection unit that collects respiratory sound data from a patient who has undergone tracheostomy; an image conversion unit that receives the respiratory sound data collected by the data collection unit and converts the received respiratory sound data into a spectrogram image; and a sputum type determination unit that determines a sputum type of the patient who has undergone tracheostomy using a deep learning model based on a pattern difference between the spectrogram images converted by the image conversion unit.

IPC Classes  ?

• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to a method for preparing induced pluripotent stem cells derived through reprogramming from basal cells derived from human respiratory tissues. Embryonic stem cells are not used in the preparation of induced pluripotent stem cells prepared using the method of the present invention, thereby eliminating ethical problems caused by destruction of embryos. In addition, induced pluripotent stem cells, which have the same genetic origin as the used basal cells derived from human respiratory tissues so that immune-compatible cell therapeutic agent customized to each individual can be provided and which are prepared from tissues similar to the tissues to be differentiated, are provided such that the reflecting of characteristics of conventional tissues to increase differentiation yield is expected.

IPC Classes  ?

• C12N 5/074 - Adult stem cells
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues

Abstract

An aspect relates to a cancer-specific polypeptide consisting of the amino acid sequence of SEQ ID NO: 1. The polypeptide according to one aspect can specifically bind to the LGR5 protein expressed in a tumor tissue, and when combined with a labeling substance (e.g., a fluorescent substance), the polypeptide enables the diagnosis of cancers expressing the LGR5 protein. Additionally, when the polypeptide according to an aspect is administered in conjugation with a photosensitizer to an organism, the photosensitizer can be activated by light irradiation to kill cancer cells, thereby enabling the prevention, alleviation, or treatment of cancer.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present disclosure relates to the detection of beta amyloid protein as an Alzheimer's disease-causing factor in the palatine tonsil and a use thereof and, more specifically, to the diagnosis of Alzheimer's disease by identifying the expression of beta amyloid and/or Staphylococcus aureus in a tonsillar sample. The present disclosure can diagnose Alzheimer's disease through the expression of beta amyloid and/or Staphylococcus aureus in a palatine tonsil tissue and, furthermore, can be very advantageously used for revealing the pathogenesis of Alzheimer's disease and for treating Alzheimer's disease.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

A glaucoma progression prediction system and method for predicting the progression of glaucoma are described. The glaucoma progression prediction system comprises: an examination module provided to derive examination images captured of deep vessels of the eye; a measurement module for measuring the deep vessel density in the examination images; an analysis module for deriving the amount of change in the deep vessel density measured in the plurality of the examination images derived at certain intervals of time; and a determination module for determining the progression of glaucoma according to the amount of change in the deep vessel density.

IPC Classes  ?

• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions

Abstract

According to embodiments, images obtained through a camera are processed to detect the bodies and faces of an optometrist and a subject, the bodies and faces being included in the images, and height adjustment units may be automatically controlled according to the detected information so that the eyes of the optometrist and the subject are moved to examination points.

IPC Classes  ?

• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating a skeletal muscle disease, a method of screening a drug for the treatment of a skeletal muscle disease, a composition for diagnosing a skeletal muscle disease, and a method of providing information for the diagnosis of a skeletal muscle disease.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

The present invention relates to a composition for immunotherapy of allergic diseases, comprising house dust mite antigens and hyaluronic acid hydrogels as active ingredients. By using hyaluronic acid as a material, and forming a crosslinking with the house dust mite antigens via a photoinitiator and visible light, it can overcome the disadvantage of easy degradation and simultaneously exploit biocompatible features. Moreover, it can provide a large amount of antigens to immune cells with a single administration, and despite this, it does not induce foreign body reactions, drug reactions, or immune responses, while generating excellent immune tolerance effects. Its safety is outstanding and it does not require repeated injections over a long period. Thus, it is expected to be useful as a preventive or therapeutic agent for allergic diseases induced by house dust mites.

IPC Classes  ?

• A61K 39/35 - Allergens
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61P 37/08 - Antiallergic agents

Abstract

The present invention relates to a self-assembling nanoparticle containing a dexamethasone and polyester polymer conjugate, a preparation method therefor, and a drug delivery composition comprising the same, wherein the self-assembling nanoparticle contains a polymer conjugate where dexamethasone is conjugated to a polyester polymer, and a drug (anticancer agent, anti-inflammatory agent), providing enhanced drug efficacy, easy nuclear entry, and simultaneous anticancer and anti-inflammatory activities.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone

Abstract

The present invention relates to self-assembled nanoparticles comprising a glycocholic acid-polymer conjugate, a method for producing same, and a drug delivery composition comprising same as an active ingredient. The self-assembled nanoparticles include a glycocholic acid-polymer conjugate and an anticancer agent, and glycocholic acid exists on the surface of the nanoparticles so that particle stability is maintained in the gastrointestinal environment, and is absorbed in a stable state so as to be distributed to various organs.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61P 35/00 - Antineoplastic agents

Abstract

Provided are a nuclear image selection method and nuclear image selection device for cancer cell determination. The nuclear image selection method comprises the steps of: obtaining a stained cell image to determine the presence of cancer cells; inputting the obtained cell image to a pre-trained algorithm as an input value, and outputting, as an output value, suitability indicating whether the cell image is suitable for determining the presence of cancer cells; and storing the input cell image and the output suitability in association with each other.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation
• G06T 7/30 - Determination of transform parameters for the alignment of images, i.e. image registration
• G06N 20/00 - Machine learning
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• C12Q 1/6841 - In situ hybridisation

Abstract

An image classification apparatus and an image classification method are provided. The image classification method includes the steps of: performing multiple different types of tests for identifying genetic variations using cell images captured from cells; acquiring multiple images through the multiple tests; associating at least one of the location information of the cells and the test type information with each of the multiple images; and classifying the multiple images into a first type of image and a second type of image different from the first type.

IPC Classes  ?

• C12Q 1/6841 - In situ hybridisation
• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

Abstract

A variable electronic suit according to an embodiment of the present invention includes: a disc having an inner space; a shaft provided to horizontally extend through the inside of the disc; a driving part formed inside the disc and connected to the shaft to linearly move the shaft; a sensor part attached to the disc to detect a status of the disc and generate a status signal; and a control part for receiving the status signal of the sensor part and adjusting the driving part on the basis of the signal to control the linear movement of the shaft, wherein one disc and another disc are coupled to form one unit and a three-dimensional structure having a net shape may be formed by multiple coupling of such units.

IPC Classes  ?

• A61H 1/00 - Apparatus for passive exercisingVibrating apparatusChiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
• A41D 31/04 - Materials specially adapted for outerwear characterised by special function or use
• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

Abstract

The present invention relates to a Leukocyte-specific protein 1 (LSP1)-deficient T cell-based anticancer immunotherapy. According to the present invention, tumor growth, tumor volume and size were reduced by means of LSP1 knockout, and LSP1 deficiency in T cells increases the number, distribution frequency, migration, and invasion of T cells, and increases the production of an anti-tumor cytokine to inhibit tumor growth and enhance tumor-killing ability. Thus, the present invention can be used for T cell-based immunotherapy.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to the pharmaceutical use of a cord blood immunosuppressive cell and, more specifically, the present invention provides the use of a human-derived cord blood immunosuppressive cell, which is selected in accordance with analysis of function and phenotype and a classification standard, as a new cell therapy product for anti-inflammation, anti-fibrosis, and prevention or treatment of myocardial infarction.

IPC Classes  ?

• A61K 35/51 - Umbilical cordUmbilical cord bloodUmbilical stem cells
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C12N 5/078 - Cells from blood or from the immune system

Abstract

The present invention relates to a technique for synthesizing with high yield a novel compound targeting mitochondria through a simple process, and the novel compound synthesized thereby. The novel compound targeting mitochondria of the present invention can be synthesized with high yield through a simple process and the compound thus prepared and nanoparticles containing same exhibit the therapeutic effects of targeting mitochondria, inhibiting gastric cancer, and treating inflammatory bowel disease, and systemic sclerosis and thus can be utilized for mitochondrial targeting applications, as anticancer compositions, or as therapeutic compositions for immune diseases.

IPC Classes  ?

• C07F 9/54 - Quaternary phosphonium compounds
• A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
• A61P 35/00 - Antineoplastic agents
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

The present invention relates to a method, performed by an electronic device, for generating patient-customized CT collateral blood flow images by using blood flow phase segmentation of dynamic contrast-enhanced CT images, and simultaneously implementing 3D subtraction CT arteriography, 3D subtraction CT venography, and color-coded 4D CT angiography.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]

Abstract

A method for three-dimensionally modeling an eyeball and optical nerves using the merging of MRI images and OCT images, comprises: (a) a step for three-dimensionally modeling an eyeball model on the basis of the shapes of an eyeballs in a first MRI head image and a second MRI head image; (b) a step for three-dimensionally modeling an ASCO model in a corrected OCT eyeball cross-sectional image; (c) a step for three-dimensionally modeling the lamina cribrosa in the corrected OCT eyeball image; and (d) a step for generating an optic nerve model by three-dimensionally modeling an optic tract connected to the three-dimensionally modeled eyeball model.

IPC Classes  ?

• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• G06T 7/00 - Image analysis

Abstract

The present disclosure comprises a memory, and a processor connected to the memory so as to generate medical quality evaluation information, wherein the processor can collect a second evaluation index for medical quality evaluation, generate, on the basis of the second evaluation index, medical quality evaluation information including an evaluation index value by performing analysis according to preset items, and provide the generated medical quality evaluation information.

IPC Classes  ?

• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G06Q 50/22 - Social work or social welfare, e.g. community support activities or counselling services

Abstract

An eyelid opening instrument having a suction function, according to one embodiment of the present invention, comprises: a frame; a pair of arms, each being rotatably coupled to one of both sides of the frame; a pair of eyelid support parts, each being connected to one of the pair of arms so as to support the upper and lower eyelids and spacing the upper and lower eyelids or releasing spacing thereof according to the rotation of the pair of arms; and a suction part provided between the pair of eyelid support parts so as to suction a saline solution on the eye.

IPC Classes  ?

• A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors
• A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

A server for predicting lymph node metastasis of early gastric cancer is disclosed. This prediction server comprises a memory and one or more processors for communicating with the memory, wherein the processor can include: a learning module including an algorithm for learning a correlation between clinical data of a patient and lymph node metastasis of an early gastric cancer; and a prediction module for predicting lymph node metastasis of early gastric cancer of the patient by using the algorithm. The provided server can derive the possibility of lymph node metastasis of early gastric cancer, and thus can determine whether gastrotomy is to be performed.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Abstract

The present invention relates to a method of producing an alveolar organoid by a dropping suspension culture technique using decellularized extracellular matrix (dECM) hydrogel, and according to the present invention, when an organoid is produced by a dropping suspension culture method using dECM, as in a living organism, an organoid in which cells and dECM are fused may be formed. Moreover, since dECM is what remains after all cells have been removed from tissue and thus is easily applied clinically, the produced organoid is expected to be useful for disease modeling, drug screening, regenerative medicine, etc.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 35/42 - Respiratory system, e.g. lungs, bronchi or lung cells

Abstract

Proposed are a phlegm suction alarm issuing apparatus and a method for a tracheostomy patient which monitor and analyze a respiratory sound of the tracheostomy patient in real time, then check congestion of phlegm, and issue a phlegm suction alarm.

IPC Classes  ?

• A61M 16/04 - Tracheal tubes
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/08 - Measuring devices for evaluating the respiratory organs

Abstract

Disclosed is a language area invasion determination apparatus including a memory unit including a language area invasion determination model, and a processor that controls an operation of the language area invasion determination model included in the memory unit. The processor trains the language area invasion determination model by using one or more training utterance data and outputs language area invasion determination data of an examiner by using test utterance data and the trained language area invasion determination model. The training utterance data and the test utterance data include utterance speech data of a speaker.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G10L 15/06 - Creation of reference templatesTraining of speech recognition systems, e.g. adaptation to the characteristics of the speaker's voice
• G10L 15/18 - Speech classification or search using natural language modelling
• G10L 25/66 - Speech or voice analysis techniques not restricted to a single one of groups specially adapted for particular use for comparison or discrimination for extracting parameters related to health condition

Abstract

Disclosed is an orthopedic implant that is implanted to replace a joint. The orthopedic implant of the present invention comprises: sensors for monitoring the state of a patient; a PEEK shell having sensors embedded therein through one opening; and a frame part having a space in which the PEEK shell is housed, wherein the frame part comprises fixing parts for fixing the position of the implanted orthopedic implant, and a PEEK shell housing designed to house the PEEK shell therein.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61F 2/44 - Joints for the spine, e.g. vertebrae, spinal discs

Abstract

The present invention relates to a pharmaceutical composition comprising nasal inferior turbinate-derived mesenchymal stem cells as an active ingredient, the composition being administered by intranasal or intramaxillary administration by means of olfactory mucosa subepithelial injection, and the like, in order to bypass the blood-brain barrier through a peri-olfactory pathway. The present invention relates to a method in which stem cells, and the like are injected intranasally, thereby enabling various therapeutic materials including the stem cells to be efficiently delivered to the brain and nervous system through the olfactory organ and a trigeminal nervous system pathway, and thus, through the method, it was confirmed that side effects occurring as a result of an entire body being exposed to a drug may be reduced, and further, a sufficient amount of inferior turbinate-derived mesenchymal stem cells may be obtained safely at a desired time at low cost with high efficiency, and it was confirmed that since the composition shares the same genetic origin with the composition-administered subject, the composition exhibits an excellent effect which is the same as or greater than the effects of bone marrow-derived mesenchymal stem cells or adipose-derived mesenchymal stem cells with fewer side effects, and thus, by intranasally administering various therapeutic materials including the nasal inferior turbinate-derived mesenchymal stem cells, the composition is expected to be capable of minimizing side effects and utilized for preventing or developing a treatment for brain and nervous system diseases.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/12 - AerosolsFoams
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present disclosure relates to a screw surgical device and method, and can provide a screw surgical device and method, which use Doppler ultrasound during surgery in which pedicle screws are used, so as to sense the vertebral artery, and thus can reduce risk of vertebral artery damage and amount of radiation exposure. Particularly, the present disclosure can provide the screw surgical device and method, which use Doppler ultrasound during surgery so as to monitor blood flow information about arterial blood adjacent to an insertion path of a pedicle screw, and thus can improve accuracy of pedicle screw fixation.

IPC Classes  ?

• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 17/70 - Spinal positioners or stabilisers, e.g. stabilisers comprising fluid filler in an implant
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 8/06 - Measuring blood flow
• A61B 8/08 - Clinical applications
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

An apparatus for analyzing a blood vessel includes a processor configured to detect a blood vessel area corresponding to the blood vessel and a stenosis area corresponding to a stenosed portion of the blood vessel, based on a machine learning model, from a blood vessel image, determine a partial area of the blood vessel area to be a comparison area for the stenosis area, based on a length of the stenosis area, and calculate a stenosis score indicating a degree of stenosis of a blood vessel of the stenosis area compared to a blood vessel of the comparison area.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume

Abstract

The present disclosure relates to a novel lipid compound and a lipid nanoparticle composition including the same and, more specifically, the lipid nanoparticle composition includes ionized lipid, helper lipid, PEG-lipid, and additives, and may mitigate changes and side effects in the delivery mechanism and enhance the protein expression efficiency by including a biofriendly vitamin-based novel lipid compound and helper lipids including neutral lipids.

IPC Classes  ?

• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• C07C 235/08 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
• C07C 235/10 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
• C07D 207/04 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
• C07D 211/06 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
• C07D 213/55 - AcidsEsters
• C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 265/30 - 1,4-OxazinesHydrogenated 1,4-oxazines not condensed with other rings
• C07D 295/15 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
• C07D 339/04 - Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
• C07D 413/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The inventive concept relates to an eyeball and eyelid protector including an eyeball cover that covers an eyeball, and an eyelid protection part that is bent and extends from one side of the eyeball cover to protect any one of an upper eyelid and a lower eyelid.

IPC Classes  ?

• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

The present disclosure relates to the preparation of citrullinated vimentin antigen-specific immune tolerogenic dendritic cells and a composition for preventing or treating heart failure after myocardial infarction comprising the same. According to the present disclosure, it is confirmed that immune tolerogenic dendritic cells differentiated by treating immature dendritic cells with citrullinated vimentin regulate the expression of immune-related factors and have an excellent therapeutic effect on heart failure caused by myocardial infarction.

IPC Classes  ?

• A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 9/04 - Inotropic agents, i.e. stimulants of cardiac contractionDrugs for heart failure
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/0784 - Dendritic cellsProgenitors thereof

Abstract

The present invention relates to a therapeutic composition for injection and oral administration for immunoregulation in osteoarthritis synovial joints. When administered through injection or orally to rats induced with osteoarthritis, the novel compound SD217 of the present invention was found to reduce pain levels and protect against cartilage damage. In addition, the composition was observed to suppress inflammatory markers IL-1β, IL-6, and TNF-α, inhibit the expression of MCP-1 and MMP13 in cartilage cell lines, and increase the expression of TIMP1, which is associated with cartilage regeneration. It was also found that the expression of cartilage formation markers SOX9, COL2A1, and Aggrecan was increased, indicating the suppression of osteoarthritis-induced cartilage damage.

IPC Classes  ?

• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

This method of detecting abnormality of an extraocular muscle in an orbital computed tomography (CT) image, which is performed by an electronic device according to an embodiment of the present invention, may comprise the steps of: extracting an orbital region from a facial CT image of an object and generating a 3D orbital CT image of the object by using a series of images including the extracted orbital region; obtaining a reconstructed 3D orbital CT image of the object by inputting the 3D orbital CT image of the object to a 3D variational autoencoder (VAE) model trained to detect abnormality in an extraocular muscle in the 3D orbital CT image; and detecting whether the extraocular muscle is abnormal from the reconstructed 3D orbital CT image.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]

Abstract

The present invention relates to a pharmaceutical composition for enhancing the anticancer effect of an immune checkpoint inhibitor, that comprises, as an active ingredient, a photosensitizer-containing polyethylene glycol or a polymeric conjugate containing polypropylene oxide, and is used in combination with an immune checkpoint inhibitor. The composition effectively activates an immune response by allowing the immune checkpoint inhibitor to penetrate into solid cancer cells that are difficult to be penetrated by the immune checkpoint inhibitor, and contains a photosensitizer so as to be able to be used for photodynamic therapy.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to: a pharmaceutical composition comprising extracellular vesicles transformed with a recombinant expression vector in which a gene expressing a ligand that binds to receptors of colorectal cancer cells is inserted into a gene that is expressed in extracellular vesicles of stem cells; and a method for preparing an expression vector for preventing or treating colorectal cancer. The present invention has an advantage in that exosomes, as extracellular vesicles, can be utilized as a drug delivery material and target and specifically act on colorectal cancer by selectively binding to colorectal cancer cells which are target cells.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/50 - Microcapsules
• A61K 9/51 - Nanocapsules
• A61P 35/00 - Antineoplastic agents
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

The present invention relates to a biguanide compound-based injection-administration and oral therapeutic agent composition for joint disease treatment. A novel compound SD282 of the present invention, when administered via injection and orally to a rat with induced osteoarthritis, has been confirmed to reduce the degree of pain caused by osteoarthritis and protect from cartilage damage. In addition, the present invention has been confirmed to inhibit the expression of the inflammatory factors IL-1β, IL-6, and TNF-α, and the expression of the bone disease factor MCP-1. In addition, the present invention has been confirmed to increase the expression of the anti-inflammatory factor IL-10, the cartilage regeneration factors TIMP1 and TIMP3, and the cartilage formation markers SOX9 and aggrecan, thereby inhibiting cartilage damage induced by arthritis.

IPC Classes  ?

• A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention relates to a diagnostic technology for infections caused by Mycobacterium tuberculosis and nontuberculous mycobacteria using next-generation sequencing and, more specifically, to a technology wherein a probe set is designed to be free of cross-reaction between Mycobacterium tuberculosis and nontuberculous mycobacteria and is used for next-generation sequencing, whereby infections caused by Mycobacterium tuberculosis and nontuberculous mycobacteria can be rapidly and accurately diagnosed. According to the present invention, specimens collected from patients suspected of having tuberculosis can be analyzed for full-length genomes of strain, thereby allowing for the rapid and accurate differentiation between Mycobacterium tuberculosis and nontuberculous mycobacteria without cross-reaction and also accurately determining the antibiotic resistance of the tuberculosis bacteria.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

Abstract

An aspect relates to a cancer-specific polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. The polypeptide according to an aspect may bind specifically to LGR5 protein expressed in a tumor tissue, and when binding to a labeling material (for example, a fluorescent material), a cancer that expresses the LGR5 protein may be diagnosed. Furthermore, when the polypeptide binds to an isotope, a metastatic tumor may be also diagnosed. When the polypeptide according to an aspect binds to a photosensitizer and is then administered to a subject, the photosensitizer may be activated through light irradiation so that cancer cells may be killed, thereby enabling the prevention, amelioration, or treatment of cancer.

IPC Classes  ?

• A61K 51/08 - Peptides, e.g. proteins
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 49/00 - Preparations for testing in vivo
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention pertains to: a surface modification method that can improve the direct intracellular delivery of a nanoparticle; and a nanoparticle produced using same and capable of direct intracellular delivery ability. More specifically, the present invention pertains to: a method for improving direct intracellular delivery by binding an arginine group-containing compound to the surface of a nanoparticle; and a nanoparticle using same. The nanoparticle according to the present invention has an arginine group-containing molecular sieve bound to the surface of the nanoparticle, and thus is stable in the in vivo pH range, can be delivered directly rather than intracellularly, and can be useful as a carrier capable of transporting drugs, proteins, or the like to be delivered directly into cells.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61K 9/51 - Nanocapsules
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• C07C 323/22 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton

Abstract

Disclosed is a thyroid cancer diagnosis server using high-density lipoprotein (HDL) cholesterol level monitoring. The present server may comprise: a memory that stores the HDL cholesterol level of a subject; and a control unit that, if an initial measured HDL cholesterol level of the subject is lower than a gender-specific set reference value, sets a significant observation period, and monitors the likelihood of the subject developing thyroid cancer if, during the significant observation period, the HDL cholesterol level measured for a plurality of times is consistently lower than the set reference value. By providing the present server, the development of thyroid cancer may be prevented.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• A61B 8/08 - Clinical applications

Abstract

The present invention relates to a novel lipid compound and a lipid nanoparticle composition comprising same. More particularly, the lipid nanoparticle composition comprises ionized lipids, helper lipids, PEG-lipids, and additives, and comprises: a novel lipid compound based on a bio-friendly vitamin; and helper lipids containing neutral lipids, and thus can alleviate changes and side effects from a delivery mechanism, and improve protein expression efficiency.

IPC Classes  ?

• C07C 235/12 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
• C07D 207/08 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
• C07D 211/14 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
• C07D 295/108 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulfur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
• C07D 231/12 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 213/46 - Oxygen atoms
• C07D 339/02 - Five-membered rings
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 9/51 - Nanocapsules
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids

Abstract

The present invention provides a method for non-destructively analyzing differentiation and maturity of a kidney organoid by using an electrochemical method. The method for analyzing differentiation and maturity of a kidney organoid, of the present invention, comprises the steps of: inoculating and culturing human-induced pluripotent stem cells on a conductive platform prepared according to the present invention; and differentiating the human-induced pluripotent stem cells into a kidney organoid, wherein, in the step of differentiating, a voltage is applied to the conductive platform so that a first electrochemical signal generated from specific cells of the kidney organoid and a second electrochemical signal generated from off-target cells are detected, and the differentiation and the maturity of the kidney organoid are analyzed according to the strength of the detected first and second electrochemical signals.

IPC Classes  ?

• G01N 27/48 - Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
• G01N 33/483 - Physical analysis of biological material

Abstract

The present disclosure may be characterized by: obtaining a user's personal information from the user's terminal; analyzing the obtained user's personal information to extract the user's attributes; generating an avatar character for the user corresponding to the extracted user's attributes; receiving virtual space information of a hospital environment from a hospital server; on the basis of the avatar character and the virtual space information of the hospital environment, providing the virtual space information of the hospital environment reflecting the avatar character to the user's terminal; and providing, to the user's terminal, the virtual space information containing medical procedures for each department of the hospital.

IPC Classes  ?

• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
• G06T 19/00 - Manipulating 3D models or images for computer graphics

Abstract

An electronic device for predicting metastasis of early gastric cancer into a lymph node on the basis of an ensemble model, according to the present invention, comprises: an image obtainment unit that obtains a whole slide image of a specimen through digital scanning; a first learning model that determines the presence of a tumor in the obtained whole slide image; a second learning model that predicts, from an image output from the first learning model, the metastasis of early gastric cancer into a lymph node in the specimen; and at least one processor that controls the image obtainment unit, the first learning model, and the second learning model, wherein the at least one processor may be configured to obtain the digitally scanned whole slide image of the specimen, train the first learning model to classify input images into a tumor, normal tissue, and non-tissue by using the whole slide image, and train the second learning model to predict the metastasis of early gastric cancer into a lymph node in the specimen by using tumor and normal tissue images.

IPC Classes  ?

• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06N 3/08 - Learning methods

Abstract

The present invention relates to a composition for inner ear-specific drug delivery, in which a steroid-based drug comprising dexamethasone particles is dispersed in an aqueous solvent by using a dispersing agent. Another objective of the present invention is to provide a pharmaceutical composition for the treatment or prevention of a disease, comprising the composition for inner ear-specific drug delivery as an active ingredient. Other objectives and technical features of the present invention are presented in more detail by the description, claims and drawings of the invention.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/10 - DispersionsEmulsions
• A61K 47/08 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen
• A61K 47/38 - CelluloseDerivatives thereof
• A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• A61K 9/06 - OintmentsBases therefor

Abstract

The present invention relates to a composition for stabilizing salivary organoids and inducing regeneration of salivary tissues. The novel compound of the present invention has been found to upregulate the expression of salivary-specific markers α-SMA, cytokeratin-14, E-cadherin, and aquaporin-5 in salivary organoids, thereby proliferating and stabilizing the salivary organoids. Furthermore, when the novel compound of the present invention is applied to a Sjögren's syndrome animal model, it upregulates the expression of organoid markers in salivary tissues isolated from the Sjögren's syndrome animal model, thereby inducing the regeneration of salivary tissue. Accordingly, the novel compound of the present invention can be advantageously utilized in the treatment methods and therapeutic screening fields for Sjögren's syndrome using salivary organoids.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 37/00 - Drugs for immunological or allergic disorders