Abstract

There is described a composition comprising an effective amount of a combination of two or more components selected from a NAD precursor; a NAMPT upregulator; a NQO1 upregulator and a NNMT (nicotinamide N-methyltransferase) downregulator.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/05 - Phenols
• A61K 31/385 - Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom

Abstract

There is described the use of an agent in the manufacture of a therapy for the treatment or alleviation of a senescence-associated disease, disorder or effect, wherein the agent is selected from one or more of A42548, A425619, alpha lipoic acid, apigenin, Artemisinin, BML-288, BTBHQ, EGCG, fluphenazine dihydrochloride, honokiol, LE300, magnolol, niclosamide, nicotinamide, nordihydroguaiaretic acid, quercetin, resveratrol and a mitochondrial uncoupler. There is also described the use of a mitochondrial uncoupler as an agent for the treatment of a senescence-associated disorder; and the use of an uncoupler in association with a senolytic agent.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 39/00 - General protective or antinoxious agents
• A61K 31/05 - Phenols

Goods & Services

(1) Body care soaps; cosmetic preparations for skincare; cosmetics; hair care preparations; make-up preparations; perfumery; personal deodorants; shampoos (2) Dietary and nutritional supplements for general health and wellbeing; nutraceutical dietary supplement for maintaining general health and wellbeing; nutraceutical food and beverages for general health and well-being (3) Medicated creams, medicated lotions, medicated body powder, medicated body gels, medicated soap, dietary supplements for medical use, and medicated food supplements all for use in the mitigation, alleviation or improvement of the effects of aging, such as skin conditions, increased frailty, loss of resilience, loss of muscle strength, loss of muscle endurance, loss of energy, loss of cognitive sharpness, loss of memory, inflammatory conditions, and age related illnesses such as atherosclerosis and cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes, hypertension and Alzheimer's disease; nutraceutical preparations for therapeutic or medical purposes for use in the mitigation, alleviation or improvement of the effects of aging, namely, skin conditions, increased frailty, loss of resilience, loss of muscle strength, loss of muscle endurance, loss of energy, loss of cognitive sharpness, loss of memory, inflammatory conditions, and age related illnesses, namely, atherosclerosis and cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes, hypertension and Alzheimer's disease (1) Aesthetic consultancy; beauty salon services; consultancy in the field of cosmetics; health spa services; medical treatment services provided by a health spa; nutritional and dietetic consultancy; providing information about dietary supplements and nutrition; spa services

Goods & Services

(1) Body care soaps; cosmetic preparations for skincare; cosmetics; hair care preparations; make-up preparations; perfumery; personal deodorants; shampoos (2) Dietary and nutritional supplements for general health and wellbeing; nutraceutical dietary supplement for maintaining general health and wellbeing; nutraceutical food and beverages for general health and well-being (3) Medicated creams, medicated lotions, medicated body powder, medicated body gels, medicated soap, dietary supplements for medical use, and medicated food supplements all for use in the mitigation, alleviation or improvement of the effects of aging, such as skin conditions, increased frailty, loss of resilience, loss of muscle strength, loss of muscle endurance, loss of energy, loss of cognitive sharpness, loss of memory, inflammatory conditions, and age related illnesses such as atherosclerosis and cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes, hypertension and Alzheimer's disease; nutraceutical preparations for therapeutic or medical purposes for use in the mitigation, alleviation or improvement of the effects of aging, namely, skin conditions, increased frailty, loss of resilience, loss of muscle strength, loss of muscle endurance, loss of energy, loss of cognitive sharpness, loss of memory, inflammatory conditions, and age related illnesses, namely, atherosclerosis and cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes, hypertension and Alzheimer's disease (1) Aesthetic consultancy; beauty salon services; consultancy in the field of cosmetics; health spa services; medical treatment services provided by a health spa; nutritional and dietetic consultancy; providing information about dietary supplements and nutrition; spa services

Abstract

There is described the use of an agent in the manufacture of a therapy for the treatment or alleviation of a senescence-associated disease, disorder or effect, wherein the agent is selected from one or more of A42548, A425619, alpha lipoic acid, apigenin, Artemisinin, BML-288, BTBHQ, EGCG, fluphenazine dihydrochloride, honokiol, LE300, magnolol, niclosamide, nicotinamide, nordihydroguaiaretic acid, quercetin, resveratrol and a mitochondrial uncoupler. There is also described the use of a mitochondrial uncoupler as an agent for the treatment of a senescence-associated disorder; and the use of an uncoupler in association with a senolytic agent.

IPC Classes  ?

• A61K 8/06 - Emulsions
• A61K 8/34 - Alcohols
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/67 - Vitamins
• A61K 31/05 - Phenols
• A61K 31/31 - Mercury compounds containing nitrogen
• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A61K 31/609 - Amides, e.g. salicylamide
• A61K 36/575 - Magnolia
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Abstract

There is described the use of an agent in the manufacture of a therapy for the treatment or alleviation of a senescence-associated disease, disorder or effect, wherein the agent is selected from one or more of A42548, A425619, alpha lipoic acid, apigenin, Artemisinin, BML-288, BTBHQ, EGCG, fluphenazine dihydrochloride, honokiol, LE300, magnolol, niclosamide, nicotinamide, nordihydroguaiaretic acid, quercetin, resveratrol and a mitochondrial uncoupler. There is also described the use of a mitochondrial uncoupler as an agent for the treatment of a senescence-associated disorder; and the use of an uncoupler in association with a senolytic agent.

IPC Classes  ?

• A61K 8/06 - Emulsions
• A61K 8/34 - Alcohols
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/67 - Vitamins
• A61K 31/05 - Phenols
• A61K 31/31 - Mercury compounds containing nitrogen
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/455 - Nicotinic acid, i.e. niacinDerivatives thereof, e.g. esters, amides
• A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
• A61K 31/609 - Amides, e.g. salicylamide
• A61K 36/575 - Magnolia
• A61P 17/00 - Drugs for dermatological disorders
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61Q 19/08 - Anti-ageing preparations

Abstract

There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACT1 peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, β-lapachone, β-hydroxy-beta-methyl-butyrate, Bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (−)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-α-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (Na AD), nicotinic acid mononucleotide (Na MN), parsley (Petroselinium crispum), phenylephrine, pokeweed mitogen, 15-Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).

IPC Classes  ?

• A61K 8/67 - Vitamins
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
• A61K 31/455 - Nicotinic acid, i.e. niacinDerivatives thereof, e.g. esters, amides
• A61K 33/30 - ZincCompounds thereof
• A61K 8/27 - ZincCompounds thereof
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61Q 19/08 - Anti-ageing preparations

Abstract

There is described a composition comprising an effective amount of a combination of two or more components selected from a NAD precursor; a NAMPT upregulator; a NQO1 upregulator and a NNMT (nicotinamide N-methyltransferase) downregulator.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61K 31/385 - Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
• A61K 31/05 - Phenols

Abstract

There is described a method of method of augmentation of plasma which comprises reducing the activity of NAD catabolic and excretory pathway enzymes and/or promoting NAD anabolic pathways, by incorporating into the plasma exogenous NAD or a NAD promoter; or a combination thereof.

IPC Classes  ?

• A61K 31/7084 - Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide

Goods & Services

Cosmetics and cosmetic preparations; skincare cosmetics; non-medicated cosmetics; cosmetics in the form of powders; cosmetics in the form of lotions; cosmetics in the form of milks; cosmetics in the form of oils; cosmetics in the form of creams; cosmetics in the form of gels; make-up preparations; non-medicated lotions; non-medicated oils; non-medicated creams; non-medicated toiletries; perfumery; soaps; shampoos; hair care preparations; personal deodorants. Medicated creams; medicated lotions; medicated body powder; medicated body gels; medicated soap; food supplements; nutritional supplements; dietary supplements and dietetic preparations; dietary supplements for medical use; medicated food supplements; nutraceuticals for use as a dietary supplement; nutraceutical preparations for therapeutic or medical purposes. Spa services; health spa services; beauty care services provided by a health spa; medical treatment services provided by a health spa; beauty treatment; beauty therapy treatments; beauty therapy services; beauty salon services; human hygiene and beauty care; consultancy services relating to beauty; providing information about dietary supplements and nutrition; consultancy and advisory services relating to dietary supplements and nutrition.

Abstract

There is described a method of method of augmentation of plasma which comprises reducing the activity of NAD catabolic and excretory pathway enzymes and/or promoting NAD anabolic pathways, by incorporating into the plasma exogenous NAD or a NAD promoter; or a combination thereof.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A61K 31/455 - Nicotinic acid, i.e. niacinDerivatives thereof, e.g. esters, amides
• A61K 31/465 - NicotineDerivatives thereof
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 17/00 - Drugs for dermatological disorders
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 31/52 - Purines, e.g. adenine

Abstract

There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACT1 peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, .beta.-1apachone, .beta.-hydroxy-beta-methy1-butyrate, bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (-)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-a-glycyrrhetinic acid, 18-.beta.-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3 ), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (Na AD), nicotinic acid mononucleotide (Na MN), parsley (petroselinium crispum), phenylephrine, pokeweed mitogen, 15-A prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).

IPC Classes  ?

• A61K 33/30 - ZincCompounds thereof
• A61K 8/27 - ZincCompounds thereof
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/67 - Vitamins
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
• A61K 31/385 - Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
• A61K 31/455 - Nicotinic acid, i.e. niacinDerivatives thereof, e.g. esters, amides
• A61P 17/00 - Drugs for dermatological disorders
• A61Q 19/00 - Preparations for care of the skin
• A61Q 19/08 - Anti-ageing preparations

Abstract

bacopa monnieri3petroselinium crispumpetroselinium crispum), phenylephrine, pokeweed mitogen, 15-Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).

IPC Classes  ?

• A61K 8/27 - ZincCompounds thereof
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/67 - Vitamins
• A61Q 19/00 - Preparations for care of the skin
• A61Q 19/08 - Anti-ageing preparations
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
• A61K 31/455 - Nicotinic acid, i.e. niacinDerivatives thereof, e.g. esters, amides
• A61K 33/30 - ZincCompounds thereof
• A61P 17/00 - Drugs for dermatological disorders

Abstract

There is described a composition comprising an effective amount of a combination of two or more components selected from a NAD precursor; a NAMPT upregulator; a NQO1 upregulator and a NNMT (nicotinamide N-methyltransferase) downregulator.

IPC Classes  ?

• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/05 - Phenols
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/385 - Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

There is described a composition comprising an effective amount of a combination of two or more components selected from a NAD precursor; a NAMPT upregulator; a NQO1 upregulator and a NNMT (nicotinamide N-methyltransferase) downregulator.

IPC Classes  ?

• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/05 - Phenols
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/385 - Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Goods & Services

Food supplements; nutritional supplements; dietary supplements and dietetic preparations, adapted for medical purposes; dietary supplements for medical use; medicated food supplements; nutraceuticals for use as a dietary supplement; nutraceutical preparations for therapeutic or medical purposes for use in the mitigation, alleviation or improvement of the effects of aging, such as skin conditions, increased frailty, loss of resilience, loss of muscle strength, loss of muscle endurance, loss of energy, loss of cognitive sharpness, loss of memory, inflammatory conditions, and age related illnesses such as atherosclerosis and cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes, hypertension and Alzheimer's disease Spa services, namely, anti-ageing skin, hair and body treatments, including such treatments being provided at retreats; health spa services, namely, anti-ageing skin, hair and body treatments, including such treatments being provided at retreats; medical treatment services provided by a health spa; providing information about dietary supplements and nutrition; consultancy and advisory services relating to dietary supplements and nutrition

Goods & Services

Cosmetics and cosmetic preparations; skincare cosmetics; non-medicated cosmetics; cosmetics in the form of powders; cosmetics in the form of lotions; cosmetics in the form of milks; cosmetics in the form of oils; cosmetics in the form of creams; cosmetics in the form of gels; make-up preparations; non-medicated lotions; non-medicated oils; non-medicated creams; non-medicated toiletries; perfumery; soaps; shampoos; hair care preparations; personal deodorants. Medicated creams; medicated lotions; medicated body powder; medicated body gels; medicated soap; food supplements; nutritional supplements; dietary supplements and dietetic preparations; dietary supplements for medical use; medicated food supplements; nutraceuticals for use as a dietary supplement; nutraceutical preparations for therapeutic or medical purposes. Spa services; health spa services; beauty care services provided by a health spa; medical treatment services provided by a health spa; beauty treatment; beauty therapy treatments; beauty therapy services; beauty salon services; human hygiene and beauty care; consultancy services relating to beauty; providing information about dietary supplements and nutrition; consultancy and advisory services relating to dietary supplements and nutrition.