Abstract

A process for impurification of semiconductor materials, comprising adjacent compensated codoping comprising: (a) providing a multicomponent host material AEGJ . . . ; (b) selecting two impurities Q and X codopants elements under the following scheme: (i) considering the host A and G, impurity Q is the chemical element with atomic number ZA−1 and impurity X is the chemical element with atomic number ZG+1; or impurity Q is the chemical element with atomic number ZA+1 and impurity X is the chemical element with atomic number ZG−1; or (ii) considering the host A and G, impurity Q is the chemical element with atomic number ZA−2 and impurity X is the chemical element with atomic number ZG+2; or impurity Q is the chemical element with atomic number ZA+2 and impurity X is the chemical element with atomic number ZG−2; or (iii) considering the host A and G, impurity Q is the chemical element with atomic number ZA−1 and impurity X is the chemical element with atomic number ZG+2; or impurity Q is the chemical element with atomic number ZA+2 and impurity X is the chemical element with atomic number ZG−1; and (c) performing the host adjacent codoping process with the selected impurities.

IPC Classes  ?

• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
• H01L 31/0288 - Inorganic materials including, apart from doping material or other impurities, only elements of Group IV of the Periodic System characterised by the doping material
• H01L 31/0296 - Inorganic materials including, apart from doping material or other impurities, only AIIBVI compounds, e.g. CdS, ZnS, HgCdTe

Abstract

An apparatus and method of simulating MIMO-type wireless channels exhibiting non-separable cross-PAS function comprising performing a convolution of the input signal with a correlated channel matrix that enables reproducing channel simulations with statistics including CCBBLE while representing a reduction in the required computational complexity.

IPC Classes  ?

• H04B 17/00 - MonitoringTesting
• H04B 7/0413 - MIMO systems

Abstract

The present invention proposes a protocol based on multiple transmission and contention rounds that schedules several transmission rounds after the contention phase is completed. The multiple transmission rounds reduce the sending of control packets and substantially increase the cross traffic on the uplink to the AP. The supporting analytical expressions for determining the traffic carried of the proposed protocol demonstrate through simulation that about 94% of the ideal throughput of available throughput can be achieved by using as few as four transmission rounds during the transmission period.

IPC Classes  ?

• H04W 74/08 - Non-scheduled access, e.g. ALOHA

Abstract

in vitroin vitro selection using recombinant proteins. According to the invention, the combination of signals produced by the aptamer-protein complexes in various platforms leads to an accurate and specific diagnosis of SARS-CoV-2 viraemia. The functionality and quality of the aptamers of the invention is demonstrated with fluorescence sandwich assays, and said aptamers can be adapted as aptasensors in various molecular diagnostics technologies.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The present invention discloses the discovery of the genes that direct the biosynthetic pathway of leupeptin, a potent protease inhibitor of the type of small peptide aldehyde (SPA). The prediction of genes that direct the biosynthesis of leupeptin was performed by EvoMining, a bioinformatic pipeline for genome mining of natural products that is based on evolutionary parameters, and was confirmed by molecular biology techniques such as insertional mutagenesis and comparison of metabolomic profiles between wild strains (producers of leupeptin) and mutant strains (non-producers of leupeptin). The leupeptin-coding biosynthetic genes contained in the isolated cluster according to the present invention were heterologously expressed in E. coli, thus achieving the production of leupeptin.

IPC Classes  ?

• C07K 5/083 - Tripeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
• C12N 15/76 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for ActinomycesVectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Streptomyces
• C12N 15/54 - Transferases (2)

Abstract

The present invention describes synergic compositions useful for the treatment of pancreatic cancer comprising combination of the compounds: Formula I, Formula II or pharmaceutically active salts thereof, which induce cytotoxicity in primary pancreatic cancer cell lines and cultures greater than that obtained for the compounds evaluated individually, thus making same a viable, effective and useful alternative for the treatment of pancreatic cancer. The antineoplastic evaluation of the compositions described showed the specificity thereof for primary pancreatic cancer cell lines and cultures, without affecting primary non-cancerous cell lines and cultures, decreasing the activation of K-Ras4B and the signalling pathways for same, whereby said antineoplastic activities improved with the synergic antineoplastic effect of the combinations of compounds C14 and P8, thereby almost completely erradicating the presence of pancreatic cancer tumours in preclinical models without exhibiting adverse effects or genotoxicity. The synergic compositions of the invention are novel pharmacological alternatives against pancreatic cancer with better properties than conventional chemotherapy.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention describes a portable thermocycler for RT-qPCR (dubbed HybOT Cycler) that integrates thermal control, illumination, and fluorescence detection into a highly integrated hybrid module, simplifying its assembly. The HybOT Cycler is wirelessly controlled from an application installed in a tablet. We characterized its thermal performance and fluorescence sensitivity and found it to behave similarly to benchtop thermocyclers. We developed a bubble-free microfluidic device that can be easily replicated from an acrylic mold to run the PCR assays. Degassing the PCR chambers for 3 min at 350 KPa with a portable vacuum pump prevented any bubbles during the assay. Both the instrument and the microfluidic mold are fabricated with digital fabrication tools and off-the-shelf electronics. Concentrations as low as 103 copies/µL of the SARS-CoV-2 N1 gene were detected. We then used our platform to screen individuals infected with the virus, reaching a sensitivity of 95% and specificity of 100%. Our portable platform can assist in diagnosing of SARS-CoV-2 and other pathogens, and its simple configuration and assembly can lead to quick adoption by labs around the world.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/6844 - Nucleic acid amplification reactions
• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• G01N 21/64 - FluorescencePhosphorescence
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B01L 7/00 - Heating or cooling apparatusHeat insulating devices

Abstract

ClostridiumClostridium, which have high antigenic capacity and generate high immunity and high antibody production in vaccinated animals.

IPC Classes  ?

• C07K 14/33 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Clostridium (G)
• A61K 39/08 - Clostridium, e.g. Clostridium tetani
• A61P 31/04 - Antibacterial agents
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The invention describes vaccines useful for the prevention of COVID-19, wherein recombinant antigens of non-glycosylated domains in the S-RBD region encoded in the SARS-CoV-2 virus genome of both the original Wuhan virus strain and the B.1.1.7 (UK) and B.1.351 (South African) virus strain variants were designed and expressed. The purified antigens of the invention were able to induce the production of polyclonal antibodies in animals, as well as a strong immune response, even by means of nasal and/or intranasal administration. Additionally, IgG antibodies that recognise said antigens were detected in sera from recovered COVID-19 patients. The invention highlights the usefulness of the antigens based on the non-N-glycosylated region of the RBD of SARS-CoV-2 for the development of monovalent and/or polyvalent vaccines effective against COVID-19, for the diagnosis of said illness, and for the prevention and immunotherapy thereof by means of the production and use of monovalent and/or polyvalent anti-COVID-19 hyperimmune plasmas and/or sera.

IPC Classes  ?

• C07K 14/165 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61P 31/14 - Antivirals for RNA viruses
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The invention relates to ADAM17 enzyme inhibitor compounds and compositions comprising them for the effective treatment of COVID-19. The administration of the described inhibitors enables the efficient reversal of severe acute respiratory syndrome (SARS) caused by SARS-CoV-2 virus infection, thereby preventing the destruction of lung tissue observed in patients affected by COVID-19 and restoring the patient's normal health condition. The inhibitors and their described compositions were administered parenterally and intranasally, observing the same beneficial effects of the treatment, and reversing the neutrophilia and leukopenia typically observed in patients affected by COVID-19. The invention also relates to the generation of an animal model that can reproduce severe acute respiratory syndrome (SARS) in a manner very similar to that observed in patients affected by COVID-19, enabling the safe evaluation of various substances with potential pharmacological activity for the treatment of COVID-19.

IPC Classes  ?

• A61K 31/54 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The invention describes a method and a microfluidic device for detecting specific antibodies for the SARS-CoV-2 virus with very high sensitivity and specificity. Such microfluidic device has the capacity to process multiple samples at the same time using multiple antigens from the virus, and it's possible to obtain the detection results through fluorescent parameters in a short period of time. With the method and microfluidic device of the invention is possible to obtain at least a sensitivity of 95% and a specificity of 91%, nonetheless both values increased to 100% when evaluating sera from individuals exposed to the virus in the fourth week after symptom onset.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• F16K 99/00 - Subject matter not provided for in other groups of this subclass
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

The invention describes volatile organic molecules with low molecular weight and high vapour pressure that are able to regulate plant growth, increasing the biomass of the root and foliar systems, and modifying root morphology by increasing the number and length of primary and lateral roots. These compounds are produced naturally by fungi in the microbiota of plant species from arid and semi-arid environments, such as agave and cactus, the compounds selected for this invention being those with biological activity and which have been validated by using the pure molecules at specific concentrations in different plant species. The biological activity of the volatile organic compounds of the invention is displayed at concentrations in a range of 1-100 µM, the total biomass increasing by 1.1-2.3 times with respect to plants not treated with these compounds. A second aspect of the invention relates to formulations made using the microorganisms that produce the identified volatile organic substances.

IPC Classes  ?

• A01N 27/00 - Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
• A01N 37/10 - Aromatic or araliphatic carboxylic acids, or thio-analogues thereofDerivatives thereof
• A01N 63/30 - Microbial fungiSubstances produced thereby or obtained therefrom
• A01P 21/00 - Plant growth regulators

Abstract

AgaveAgave fructans or agavins useful for the treatment of diseases caused by neuroinflammation, or where intestinal dysbiosis generates neuroinflammation, in particular, for the treatment of Alzheimer's disease. The present invention represents the first report to confirm neuroinflammation caused by intestinal dysbiosis as one of the causes of the evolution and development of Alzheimer's disease.

IPC Classes  ?

• A61K 31/733 - Fructosans, e.g. inulin
• A61K 36/88 - Liliopsida (monocotyledons)
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention refers to a self-sustainable mobile system for making water drinkable that uses a particular configuration of transducer devices for capturing and transforming energy, including first device or system for capturing solar energy of the photovoltaic type used to energize pumps and feed the fluid from these pumps to the different purification stations, second device or system of thermosolar type or photo-thermal system that allows to heat water to be treated, and third device or system of photo-luminescent type in charge of concentrating the light and transmitting it through fiber optic means towards a photocatalytic reactor. The system has the ability to modify its configuration to reverse the order of the purification chambers depending on the needs of operation to thus result in a reduction in the concentration of heavy metals and semimetals.

IPC Classes  ?

• C02F 9/00 - Multistage treatment of water, waste water or sewage

Abstract

The present invention describes pharmaceutical compositions comprising a compound that has the formula (Compound C19), which specifically inhibits mutated GTPase KRAS4b, making the compositions useful for the effective treatment of colorectal cancer. Compound C19 acts as a stabilizer of the KRAS4b-PDEδ complex, decreasing the proliferation of cancer cells in colorectal cancer, and increasing apoptosis through decreased activation of KRAS4b oncogenic signaling.

IPC Classes  ?

• C07C 237/20 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 35/04 - TarsBitumensMineral oilsAmmonium bituminosulfonate

Abstract

The present invention describes pharmaceutical compositions comprising compounds that have the formula and formula (compounds D14 and C22 respectively) that specifically inhibit the KRas4B- PDE6δ interaction, making them useful for the effective treatment of pancreatic cancer. The compounds of the invention stabilized the protein-protein interaction in the KRas4B-PDE6δ complex showing antineoplastic activity against pancreatic cancer cells, reduced the viability in the human pancreatic cancer cells but not in the normal pancreatic cells and induced cellular death via apoptosis.

IPC Classes  ?

• C07C 233/08 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
• C07C 237/20 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61P 35/04 - Antineoplastic agents specific for metastasis

Abstract

Described as a method for recovering lithium from clay, which comprises: (a) providing a quantity of clay that has a content of muscovite and sanidine clay; (b) separating the clay particles that have a particle size of less than 20 µm, preferably by means of sieving or magnetic separation; (c) leaching said particulate material with acid, preferably sulphuric acid; and (d) obtaining a quantity of leached lithium.

IPC Classes  ?

• C22B 26/12 - Obtaining lithium
• C22B 3/06 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in inorganic acid solutions
• C22B 3/08 - Sulfuric acid
• C22B 3/22 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means
• C22B 3/44 - Treatment or purification of solutions, e.g. obtained by leaching by chemical processes

Abstract

Broadband channel emulation is currently carried out by channel executions based on dispersion functions dictated by communication standards with the purpose of performing tests and validating new communication schemes. However, the channel models available in the prior art consider only the simulation of channel which has stationary statistics and wherein the dispersion is separable, allowing only unrealistic channel simulations. The present invention describes a method and apparatus for emulating doubly selective scene channels, wherein the simulation and emulation has a randomly long duration for a stationary or non-stationary channel, with non-separable dispersion. The above is achieved by combining the techniques of channel orthogonalisation, decomposition of the correlation tensor in the Doppler variable in frequency-dependent correlation matrices, followed by a matrix factorisation of each of the aforementioned matrices and, finally, the use of the window method in order to be able to generate randomly long executions. This makes it possible to concatenate channel executions coming from same or different NSDFs, thus reproducing stationary or non-stationary channels, respectively.

IPC Classes  ?

• H04B 17/391 - Modelling the propagation channel

Abstract

The invention describes a method and apparatus for generating single-hand multi-h CPM signal waveforms, in which all the signal-generation parameters can be reconfigured. This apparatus amply beats the transmitters disclosed in the prior art, such as that based on memories and that based on integration, in terms of hardware resource consumption, while also having reliable performance in terms of SQNR for any of the implementations. The described generation methodology is divided into two steps: one associated with the moving average term and one with the autoregressive term. The present invention proposes a generation of the autoregressive term based on digital signal processing and memory elements. The proposed method for generating CPM signals is carried out by DSP and memory elements in order to improve the cases in which the transmitter based only on DSP has poor performance in terms of SQNR. When the symbols to be transmitted are multiplied by the one or more modulating indices, the product is sent to an interpolation filter, which responds to the pulse with the PSR of the CPM scheme. On the other hand, in the autoregressive section, the symbols to be transmitted are multiplied by the numerator of the one or more modulation indices in order to generate a change in the current position of the phase. The sum of the outputs of the autoregressive term obtained from memory elements and the autoregressive term generated by the interpolation filter is used as an argument for the normalised sine and cosine functions.

IPC Classes  ?

• H04L 27/18 - Phase-modulated carrier systems, i.e. using phase-shift keying

Abstract

The invention relates to a communication system and method for overcoming the distortions and effects introduced by the V2V communication channels. In contrast to any existing invention operating under the same conditions, the described apparatus uses a completely novel receiving technique based on the concept of non-linear detection of signals with frequency dispersion. The receiver of this apparatus can achieve a level of performance such that it efficiently exploits the diversity in frequency, together with the band structure of the equivalent channel matrix. The performance achieved in terms of noise immunity is much better than any technique that has been found up to now and also requires a much smaller number of calculations in the receiver.

IPC Classes  ?

• H04L 27/32 - Carrier systems characterised by combinations of two or more of the types covered by groups , , , or

Abstract

The present invention relates to mixtures of dNTP nucleotides and/or the analogues thereof, in different proportions and/or different molar concentrations of each of same, which allow optimum polymerisation of nucleic acids, regardless of the content and distribution thereof inside the polymer. The invention also relates to a process for amplifying and sequencing nucleic acid polymers, characterised in that it uses one or more of said mixtures dNTP. The mixtures can be used to generate nucleotide polymers in any variant of PCR or RT-PCR, or to sequence same using conventional methods, pyrosequencing or third-generation sequencing.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The invention relates to a method and apparatus for emulating channels having time-selective and arbitrary dispersion scenarios (channels with isotropic and non-isotropic distributions in the angle of arrival or, otherwise, asymmetric and non-asymmetric channels with spectral power densities and which are affected by Doppler shifts). The present invention also allows arbitrarily long channel realisations to be generated for channels having non-stationary statistics, allowing real channels to be emulated. Stationary and non-stationary channels are simulated by concatenating independent sequences and by applying a window to the sequences generated, using a forming filter that enables this type of model to be implemented in time-selective channel emulators by means of hardware. The sequences are channel realisations obtained using any method for generating stochastic processes such as: adding orthogonal functions, adding sine waves/cosine waves, filtering, Fourier transform, etc.

IPC Classes  ?

• G06F 17/10 - Complex mathematical operations
• H04W 24/00 - Supervisory, monitoring or testing arrangements

Abstract

The invention relates to a system and method for overcoming the distortions and effects introduced by the highly variant channels of one or more antennas in the transmitter as well as in the receiver. It uses a reception technique based on the concept of virtual trajectories which does not require iterative calculations or the solution of linear systems in operating time, thus saving a considerable number of operations. The receiver of this apparatus makes it possible to convert the rapid variations of the channel into virtual antennas, considerably increasing the signal-to-noise-plus-interference ratio. The performance obtained in terms of noise immunity is much better than any known technique and also requires a much smaller number of calculations in the receiver.

IPC Classes  ?

• H04B 7/04 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas
• H04W 24/02 - Arrangements for optimising operational condition

Abstract

Streptomyces lividans 66, which we have called livipeptin. Using genome mining of natural products, we predicted that SLI0883-5 genes encode an unprecedented biosynthetic system, unusually small (4.6 Kbp), which produces an acylated peptide aldehyde. Because of the chemical characteristics of the predicted compound, we postulated its anti-proteolytic activity, which we confirmed by identifying and purifying this compound through metabolic profiles of HPLC and MS of the mutated strain lacking these three genes and the wild strain. To this objective, we identified the conditions wherein these genes are strongly expressed. The livipeptin was purified and its inhibitory activity on the proteolytic activity of selected proteases was demonstrated in vitro. The design of an expression cassette for its heterologous expression is also described plus its use for heterologous protein production.

IPC Classes  ?

• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C07K 5/065 - Dipeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
• C07C 279/12 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

The present invention relates to a simple field method for detecting microorganisms, such as pathogenic agents, in plants of agronomic interest, which comprises extracting the genetic material of the plant, performing isothermic amplification of the genetic material of the microorganism at ambient temperature, and detecting same by means of colorimetric reaction in the visible spectrum, wherein the microorganism can be a phytopathogenic virus infecting plant tissue, such as foliar tissue. In particular, the invention allows, for example, the presence of papaya ringspot virus (PRSV) and papaya mosaic virus (PapMV) in papaya plants, to be easily detected in the field, without the use of devices or equipment commonly used for the detection thereof in laboratory facilities.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• C12R 1/94 - Plant viruses

Abstract

The present invention relates to giant secreted (extracellular) vesicles (referred to as VEGs) that are associated with parasitic protozoan species, which have dimensions of 500-400 nm in diameter, and to methods to allow their induction, secretion and purification. These vesicles possess proteolytic activity and are composed of a large amount of proteins; in particular, they were obtained from Entamoeba histolytica trophozoites (referred to as EhVEG) and from other parasitic protozoa, such as Giardia lamblia and Trypanosoma cruzi. The invention also relates to the use of such vesicles, for example EhVEGs, to immunize mammals susceptible to infection by Entamoeba histolytica. The present invention also describes effective vaccine immunogenic pharmaceutical compositions comprising the induced and isolated VEGs, for example EhVEGs, which are useful for the treatment and prevention of amebic hepatic abscess. The present invention represents the first report that demonstrates and/or verifies that E. histolytica secretes extracellular vesicles of large dimensions into the culture medium.

IPC Classes  ?

• C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
• A61K 35/68 - Protozoa, e.g. flagella, amoebas, sporozoans, plasmodium or toxoplasma
• A61K 39/002 - Protozoa antigens

Abstract

The present invention relates to new chemical compounds of formula (I) with a structure different from nitroimidazoles, and to equally novel uses thereof for the treatment of trichomoniasis, making said compounds useful for application by means of pharmaceutical compositions. Also, the administration of said compounds does not cause adverse side effects in comparison with compounds widely known in the field, such as metronidazole.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline

Abstract

The present invention relates to novel chemical compounds of formula I with a structure different from nitroimidazoles, and to equally novel uses thereof for the treatment of trichomoniasis, making said compounds useful for application by means of pharmaceutical compositions. Also, the administration of said compounds does not cause adverse side effects in comparison with compounds widely known in the field, such as metronidazole.

IPC Classes  ?

• C07D 239/40 - One sulfur atom as doubly bound sulfur atom or as unsubstituted mercapto radical
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine

Abstract

The present invention relates to pharmaceutical compositions that can be used for the treatment of trichomoniasis, which comprise compounds with the chemical structure and which also exhibit a synergic effect and do not have the typical side effects of compositions comprising compounds commonly used in the treatment of this disease, such as metronidazole.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• C07D 239/40 - One sulfur atom as doubly bound sulfur atom or as unsubstituted mercapto radical
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Abstract

The invention relates to a process for the detection of nucleic acid sequences, particularly segments 4, 5 or 7 of the H1N1 influenza A virus by one- or two-step real-time and end-point RT-PCR, as well as oligonucleotides that recognize any variable of the H1N1 influenza A virus. The invention also comprises virus detection systems including these oligonucleotides. The amplification obtained with said oligonucleotides can give a high degree of certainty of infection by the H1N1 influenza A virus.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The invention relates to equipment that permits the nutraceutical value of fruit to be increased via exposure, in controlled conditions, to ultraviolet light in the region of the electromagnetic spectrum corresponding to the C-portion (UV-C). The equipment comprises six blocks of elements or systems: containment and security, radiation, cooling, exposure or support, monitoring and control and portability.

IPC Classes  ?

• A23B 7/015 - Preserving by irradiation or electric treatment without heating effect
• A23L 5/30 - Physical treatment, e.g. electrical or magnetic means, wave energy or irradiation

Abstract

A modified orthogonal frequency-division multiplexing (OFDM) communication system based on virtual decomposition of the channel is proposed. The system is fully compatible with standard OFDM transmitters and maintains several blocks of standard OFDM receivers. The proposed approach achieves also incoherent reception of multicarrier signals even with a simple autocovariance DPSK detector. This novel system substantially surpasses the performance of current approaches while requiring low computational complexity. Two preferred embodiments are described; one with coherent reception using pilot signals, and the second with incoherent receiver of differentially encoded signals.

IPC Classes  ?

• H04L 25/03 - Shaping networks in transmitter or receiver, e.g. adaptive shaping networks
• H04L 27/26 - Systems using multi-frequency codes

Abstract

The present invention describes the discovery of the genes that direct the biosynthetic pathway of leupeptin, a potent protease inhibitor of the type of small peptide aldehyde (SPA). The prediction of genes that direct the biosynthesis of leupeptin was performed by EvoMining, a bioinformatic pipe for genome data mining of natural products based on evolutionary parameters and was confirmed by molecular biology techniques such as insertional mutagenesis and the comparison of metabolomic profiles between wild strains (producers of leupeptin) and mutants (non producers of leupeptin). Biosynthetic genes of leupeptin were cloned and expressed heterologously in other expression systems of bacterial origin, thus achieving the production of leupeptin. It also describes the design of a cassette for heterologous production of leupeptin and its use for producing leupeptin and variants of it using synthetic biology, and to produce recombinant proteins.

IPC Classes  ?

• C07K 5/083 - Tripeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 9/88 - Lyases (4.)
• C12N 9/10 - Transferases (2.)
• C12N 15/54 - Transferases (2)
• C12N 15/60 - Lyases (4)

Abstract

The present invention relates to a device for surface recording of the masseter muscles comprising: a 2-channel electromyograph machine; a first set of three surface electrodes and a second set of three surface electrodes, wherein with the aid of a head support the first set of surface electrodes is placed on the right side of the head of a subject under study, while the second set of surface electrodes is placed on the left side, both sets or electrodes are disposed at the level of the masseter muscles of the subject under study, whereby the EMG surface activity generated during a test conducted on the subject under study is registered through both sets of surface electrodes and an EMG signal is sent to the electromyograph machine through a first and a second channel for processing and subsequent transfer to a personal computer that allows the analysis of the processed data; and a power supply that provides the power necessary for the proper and optimum device performance.

IPC Classes  ?

• A61B 5/0488 - Electromyography

Abstract

The invention describes the computational automation of baseball, which is supported on a finite state automaton and a formal language for describing any correct play. Using this automaton and this language ensure the mathematically correct modelling and implementation of the algorithms for computer simulation of a baseball game. For algorithmic automation of baseball according to the invention, a formal grammar is defined that translates the rules of the baseball game; by using said grammar, a formal language is generated to describe any possible play during a baseball game. This formal language is read by the corresponding state automaton. Also, a generator of baseball plays creates the plays based on average probability occurrence of each of these plays in games played by humans in professional tournaments. Therefore, plays such as "STRIKES", "FOULS", "HITS", "HOMERUN", including the number of runs, etc., occur according the rules of the game and with the average frequency with which would occur in real life matches.

IPC Classes  ?

• G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
• G06F 17/00 - Digital computing or data processing equipment or methods, specially adapted for specific functions

Abstract

The present invention describes a new peptide aldehyde produced naturally by Streptomyces lividans 66, which we have called livipeptin. Using genome mining of natural products, we predicted that SLl0883-5 genes encode an unprecedented biosynthetic system, unusually small (4.6 Kbp), which produces an acylated peptide aldehyde. Because of the chemical characteristics of the predicted compound, we postulated its anti-proteolytic activity, which we confirmed by identifying and purifying this compound through metabolic profiles of HPLC and MS of the mutated strain lacking these three genes and the wild strain. To this objective, we identified the conditions wherein these genes are strongly expressed. The livipeptin was purified and its inhibitory activity on the proteolytic activity of selected proteases was demonstrated in vitro. The design of an expression cassette for its heterologous expression is also described plus its use for heterologous protein production.

IPC Classes  ?

• C07K 5/065 - Dipeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
• C12N 15/31 - Genes encoding microbial proteins, e.g. enterotoxins

Abstract

The invention describes an easy manufacturing culture medium obtained from the avocado seed for the growth and support of microalgae, fungi, yeasts, moss, bacteria and plants.

IPC Classes  ?

• C12N 1/12 - Unicellular algaeCulture media therefor
• C12N 1/14 - Fungi Culture media therefor
• C12N 1/16 - YeastsCulture media therefor
• C12N 1/20 - BacteriaCulture media therefor

Abstract

The invention relates to strains of Lactobacillus brevis, LbH2, LbH3, LbH5, LbH9 and LbH13, isolated from the juice of Agave salmiana and the method for the isolation thereof, wherein said strains have bile salt hydrolase (SBH) activity as well as probiotic properties that help to prevent an increase in total cholesterol. The invention also relates to a mixture of strains of Lactobacillus brevis, also known as Lactobacillus brevis mix, which prevents damage to the liver given that it reduces the activity of the serum enzymes, markers of liver damage.

IPC Classes  ?

• C12R 1/24 - Lactobacillus brevis
• A61K 35/74 - Bacteria
• A61P 15/16 - Masculine contraceptives

Abstract

The present invention provides a system for performing an anti-tumor gene therapy with autocrine and paracrine effects, specifically targeting cancer cells expressing NTSR1 receptor, wherein the system comprises the use of a minimum fragment of the GAS1T gene encoding 167 amino acids, which are sufficient to induce cell arrest, apoptosis and suppression of tumor growth and delivering the genetic material encoding for said fragment via the NTS-polyplex nanoparticles; for example, intravenously, to be expressed in said cancer cells.

IPC Classes  ?

• C12N 15/12 - Genes encoding animal proteins
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

The invention relates to methods for obtaining hydroxyapatite from bone, which has a percentage crystallinity similar to certified standard samples, making it a high-quality product. The process described comprises steps involving primary cleaning of the starting material, fat removal, deproteinization and, optionally, elimination of carbonates. The process of the invention can be used to obtain hydroxyapatite having physicochemical characteristics comparable to commercial hydroxyapatites, as well as including the elements that naturally characterise bone tissue.

IPC Classes  ?

• A61L 27/02 - Inorganic materials
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/32 - Phosphorus-containing materials, e.g. apatite

Abstract

The invention relates specifically to the chemical synthesis, identification and determination of the chemical structure of analogues of the caffeic acid phenethyl ester (CAPE) with activity against cancer, especially against liver cancer. The invention also relates to the production of pharmaceutical compositions containing same and to the use thereof for preventing and treating cancer by means of the chemoprotective capacity thereof.

IPC Classes  ?

• C07D 213/56 - Amides
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• C07C 233/11 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings

Abstract

The present invention describes the use of polystyrene (PS) and polyethylene terephthalate (PET) obtained from recyclable materials as host lattice for obtaining luminescent films. Organic pigments (OPs) and fluorescent organic pigments (FPOs) were used on these materials as dopants; e.g., blue, yellow and red, having luminescent emissions at 450, 510 and 590 nm, respectively, using also rare earths and nanoparticles of Al2O3:Tb and Al2O3:Eu as dopants. PS and PET films were obtained by spray pyrolysis using glass and commercial GaN LEDs substrates (with emissions at 390 nm for violet light and 455 nm for blue light). Measurements of photo and electroluminescence of the films obtained were made using PS films properly doped in electroluminescent devices emitting blue and violet light, which resulted in the emission of white light.

IPC Classes  ?

• C08J 5/18 - Manufacture of films or sheets
• C08K 3/08 - Metals
• C08K 3/22 - OxidesHydroxides of metals
• C08L 25/06 - Polystyrene
• C08L 67/02 - Polyesters derived from dicarboxylic acids and dihydroxy compounds
• C09D 125/08 - Copolymers of styrene
• C09D 131/08 - Homopolymers or copolymers of esters of polycarboxylic acids of phthalic acid

Abstract

The present invention relates to the field of neurotrophic gene therapy and is based on genomics and nanotechnology in combination with a drug therapy, thereby promoting mitogenic, neurogenic, and neuritogenic events for the treatment of Parkinson's disease at any stage. More particularly, the invention comprises associating the systemic administration of a dopaminergic agonist D3 with BDNF gene transfection using NTS-polyplex macromolecular vector in dopaminergic neurons of the substantia nigra to promote the restoration of the nigrostriatal dopaminergic pathway in the treatment of Parkinson's disease.

IPC Classes  ?

• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 15/12 - Genes encoding animal proteins
• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61K 38/18 - Growth factorsGrowth regulators
• A61P 25/16 - Anti-Parkinson drugs

Abstract

The present invention describes the use of propylparaben, a widely known antimicrobial, for decreasing neuronal injury induced by Status epilepticus. An objective of the invention is the administration of propylparaben immediately after the occurrence of Status epilepticus to prevent neuronal injury and the possible development of epileptogenesis, as well the neurocognitive disorders associated with this condition.

IPC Classes  ?

• C07C 69/84 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
• A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
• A61P 25/08 - AntiepilepticsAnticonvulsants

Abstract

The present invention relates to methods for increasing the content of nutraceuticals and antioxidant capacity of perishable fruits, by combining irradiation with ultraviolet light (UV-C) and storage at freezing temperatures in different presentations. According to the invention, it is possible to increase the concentration of flavonoids, such as phenols and anthocyanins, and also the antioxidant capacity of strawberry fruits (Fragaria x ananassa). The main objective of the present invention is to improve the postharvest quality of fruits, particularly strawberry, by stimulating strawberry fruits with different doses of UV light and different temperatures.

IPC Classes  ?

• A23L 1/025 - Physical treatment, e.g. with wave energy, irradiation, electrical means, magnetic fields (cooking A23L 1/01; preserving A23L 3/00, A23B)
• A23B 7/015 - Preserving by irradiation or electric treatment without heating effect
• A23L 1/212 - Preparation of fruits or vegetables (of pulse A23L 1/20; treating harvested fruit or vegetables in bulk A23N)
• A23L 3/28 - Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by irradiation without heating with ultraviolet light

Abstract

The present invention relates to pharmaceutical compositions having analgesic and/or anti- inflammatory effect comprising the combination of diosmin and hesperidin, and the use of said composition for the treatment of pain; e.g., moderate to severe pain, chronic pain, and/or neuropathic pain. The main objective of the present invention is to provide a composition comprising the combination of diosmin and hesperidin, both natural products, in treating neuropathic pain.

IPC Classes  ?

• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies

Abstract

The present invention relates to a biometric system for user identification, which implements the hippus pattern of the pupil as a valid biometric feature for the authentication of staff, and which generally comprises a retrieval and storage block of pupil images; a digital processing block to processing pupil images to obtain the hippus pupilogram and a biometric pattern of the hippus; and a storage block to store said biometric pattern of the hippus for future correlations.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

Abstract

The present invention relates to the generation of transgenic plants resistant to infections caused by microorganisms restricted to the phloem, and it comprises the induction of the expression of a chimeric or fusion protein, which comprises a phloem protein of Citrus aurantifolia (CsPP16), a linker protein and a protein with antimicrobial activity; for example, with antibacterial activity or antibacterial hydrolytic enzyme. The portion of the fusion protein corresponding to the CsPP16 protein can exert its function of simplasmic movement, which occurs via the plasmodesmata of the plant to reach the phloem sieve tubes, while the antimicrobial portion can act to eliminate the microorganism, which settles in the phloem.

IPC Classes  ?

• A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The present invention relates to methods for detoxification of agro products contaminated by mycotoxins. The invention relates to the application of potassium salt of naphthalene acetic acid (K- NAA) mainly in agro products stored that are susceptible of contamination by aflatoxins produced by filamentous fungi (actinomycetes) of the Aspergillus genus. The invention includes K-NAA compositions designed for the aflatoxin detoxification of such agro products, particularly basic grains, including maize. The described method significantly reduces the aflatoxin contamination, ensuring public health of the consumer by preventing aflatoxicosis.

IPC Classes  ?

• A23L 3/3454 - Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
• A23L 3/3463 - Organic compounds; Microorganisms; Enzymes
• A23L 1/015 - Removal of unwanted matter, e.g. deodorisation, detoxification (A23L 1/211 takes precedence);;

Abstract

The present invention relates to the involvement of serotonergic receptors 5-TH2 with increased insulin sensitivity, principally by increasing peripheral glucose capture. The present invention has as main objective to use agonists of serotonergic receptors 5-HT2, such as indorenate (an hypertensive agent that acts as an agonist of central 5-HT1A receptors) for treating disorders related with increased blood glucose, and to improve insulin sensitivity by acting as 5-HT2 agonist in the periphery.

IPC Classes  ?

• A61K 31/404 - Indoles, e.g. pindolol
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention relates to a non-thermal plasma jet device as spatial ionization source for ambient mass spectrometry of the type which allows a free adjustment of the geometry of the plasma beam, wherein the device comprises a double dielectric barrier probe of non-thermal plasma or NTP probe, which generates a non-thermal plasma jet; a high voltage and high frequency transformer circuit that connects an outer electrode through which it is possible to perform a discharge for the ionization of a gas which produces plasma, and wherein said plasma generator circuit is in turn connected to a source of AC power; an inner electrode which is grounded and allows to perform the discharge for the production of plasma; a storage tank of a gas serving as discharge gas; a test sample on which the non-thermal plasma jet is applied; and a ion transfer adapter to direct the ions produced by the device from the vacuum-free sample into a mass analyzer. The device described allows to directly analyzing live samples (plants, for example) without causing any damage to them.

IPC Classes  ?

• H01J 49/10 - Ion sourcesIon guns
• H05H 1/24 - Generating plasma

Abstract

The present invention pertains to the field of genomics and nanotechnology, specifically to the in vivo gene expression technologies and their application in gene therapy. It consists of the performance of the NTS-polyplex nanocomplex, which can carry nucleic acids to the neurons, involving neurotrophic therapy to treat neurodegenerative diseases. In particular, the present invention addresses the treatment of Parkinson's disease by the regulated expression of the BDNF neurotrophin.

IPC Classes  ?

• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
• A61K 38/18 - Growth factorsGrowth regulators
• A61P 25/16 - Anti-Parkinson drugs
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

The present invention relates to methods for identifying bean plants tolerant to drought. This method is based on the molecular and physiological evaluation of plants, which are exposed to water stress. The molecular evaluation is performed by identifying and quantifying the m RNAs of genes accumulated under water stress and the physiological evaluation by measuring the photosynthesis. For the development of the present invention, we took as study model the Pinto Villa bean variety from which various different nucleotide sequences of 44 genes were identified, overexpressing in the bean plants when these are exposed to water stress. Therefore, it represents the value of employing said sequences as molecular markers useful to identify bean plants tolerant to drought. This invention allows assisting the selection of drought tolerant plants with molecular markers and physiological parameters in bean seedlings, without having to wait for the occurrence of the life cycle of the plant, by that reducing the time of identification of drought tolerant plants noticeably.

IPC Classes  ?

• A01H 1/04 - Processes of selection
• A01H 5/10 - Seeds
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The present invention relates to a combined method of secondary ion mass spectroscopy (SIMS) and energy dispersed X-ray (EDX) for quantitative chemical analysis of solid materials and thin films, comprising the steps of a) installing a energy dispersed detector Si(Li) on a free port of a mass spectrometer for X-ray recording; b) placing the study sample in an ultra high vacuum (UHV) chamber of the mass spectrometer; c) activating the electron gun for the mass spectrometer to achieve the characteristic X-ray excitation of the study sample, wherein the electron gun provides a moderately focused electron beam with energies that can vary from 0 to 15keV and currents from 0 to 100 mA; d) analyzing the X-rays generated in step c) with the energy dispersed detector Si(Li), and find sensibility factors (RSF); e) calibrating the SIMS data with the sensitivity factors (RSF) obtained by EDX quantitative analysis of step d) using existing theories; and f) analyzing with SIMS any unknown material of the study sample.

IPC Classes  ?

• G01N 23/20 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using diffraction of the radiation by the materials, e.g. for investigating crystal structureInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materialsInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using reflection of the radiation by the materials
• G01N 23/225 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material using electron or ion microprobes

Abstract

The present invention relates to a method for the synthesis and in-situ doping of carbon nanotubes (CNT). The method of the invention enables the manufacture of nanotubes in an economically viable way and free from amorphous carbon, resulting in that their purification is performed only by the catalyst, which process requires just a few washes with low-concentration commercial acid. Also, this process allows the in-situ doping of carbon nanotubes with different doping elements during and after growth.

IPC Classes  ?

• C01B 31/02 - Preparation of carbon; Purification

Abstract

The present invention describes a system of gene carrier nanoparticles capable of specifically internalize into cancer cells, eg, cancer cells involved in breast cancer, in vitro and in vivo. The system described allows the introduction of therapeutic genes specifically into target cells through NSTR1 receptor-mediated endocytosis of said system, making it possible to provide treatment for this type of conditions, for example by systemic, intravenous, or in situ administration.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates

Abstract

The present invention provides a nontoxic method for the selection of transformed cells from a cell population consisting of transformed and untransformed cells. The method comprises the following steps: a) introducing into a cell at least one nucleotide sequence of interest and at least one selection nucleotide sequence to obtain genetically transformed cells, where the selection nucleotide sequence comprises a sequence promoting the inhibition of endogenous trehalase enzyme; b) placing the population of transformed and untransformed cells in a culture medium containing an osmoregulating substance such as PEG 8000; c) selecting the transformed cells from the population based on the ability of transformed cells to survive and grow in the presence of the osmoregulating substance conferring the plants derived from these genetic transformation events, for example, drought and/or cold tolerance capacity.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)

Abstract

The present invention relates to polyene macrolide derivatives according to the formula (I): wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics.

IPC Classes  ?

• C07H 17/08 - Hetero rings containing eight or more ring members, e.g. erythromycins

Abstract

The present invention relates to polyene macrolide derivatives according to the formula (I): wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics.

IPC Classes  ?

• C07H 17/08 - Hetero rings containing eight or more ring members, e.g. erythromycins

Abstract

The present invention relates to compositions comprising Agave fructans to stimulate the absorption of mineral salts and the fixation of bone in mammals, under osteoporosis condition, resulting in pronounced beneficial effects also in lowering plasma glucose levels and body weight reduction measured in ovariectomized mice, administering a standard diet and the compositions of the invention. The Agave fructans compositions of the invention have effects that outweigh inulin-type fructans known from other species, attributable mainly to the branched and non-linear structure of Agave fructans, as is the case with inulin.

IPC Classes  ?

• A61K 31/70 - CarbohydratesSugarsDerivatives thereof
• A61K 31/702 - Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Abstract

Abstract. This invention relates to a high-capacity data hiding method for audio signals following the OFDM concept. It is based on changing the phase component of the audio signal via an M-order Phase Shift Keying (MPSK) modulator on selected frequency samples of the audio signal. This approach allows the data hiding capacity and perceptual distortion to be controlled by the number of altered frequency components of the audio signal and the severity of this alteration. The data hiding capacity can be estimated a priori independently of the audio signal features. In addition, due to the relation of the proposed scheme with the traditional use of MPSK modulation, the BER of the encoded data is analytically derived, therefore, it is known in advance, allowing the integration of channel encoders. Results obtained with representative test cases show that the proposed algorithm provides an increase of one order of magnitude in data payload compared with state-of-the-art works.

IPC Classes  ?

• G10L 19/00 - Speech or audio signal analysis-synthesis techniques for redundancy reduction, e.g. in vocodersCoding or decoding of speech or audio signals, using source filter models or psychoacoustic analysis

Abstract

The present invention relates to methods of detection and treatment of osteoarthritis (OA) at early stages of development of the disease through the detection and neutralization of IL-Ιβ as an early biomarker of OA. The method of the invention also refers to the relationship of the expression of pro-inflammatory and anti-inflammatory cytokines in healthy cartilage and osteoarthritic cartilage as a mean to assess the role IL-Ιβ as a potential biomarker of early OA. The present invention also provides efficient methods for treating OA at early stages by using inhibitors of IL-Ιβ activity in the cartilage, thereby preventing the progression of OA to stages of difficult treatment or to reverse the damage on the cartilage by the presence of IL-Ιβ.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Combinations of Bacillus thuringiensis (Bt) proteins and nucleic acids encoding these Bt proteins are disclosed. Plants transformed with nucleic acids encoding these Bt proteins are also disclosed.

IPC Classes  ?

• A01N 63/02 - Substances produced by, or obtained from, microorganisms or animals
• C07K 14/325 - Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The present invention describes efficient and low cost fermentation methods for the efficient production of medium chain poli-3-hydroxyalkanoates (PHAs), which comprise the growth of microorganisms producing PHAs using vegetable oils as carbon source, either in the presence or absence of saccharide. The methods of the invention comprise producing biomass in batch culture, subsequently producing biomass in fedbatch culture by means of the addition of saccharide and a nitrogen source to the culture medium and finally producing PHAs by means of the addition of vegetal oil as carbon source with limitation of nitrogen or phosphorus. By means of the method of the invention, at least 90% in dry weight of medium chain PHAs with respect to dry biomass is obtained from the culture medium, presenting from 5 to 10% of medium chain monomeric units in their structure.

IPC Classes  ?

• C08G 63/06 - Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxy carboxylic acids
• C12P 7/62 - Carboxylic acid esters

Abstract

The present invention describes a scan adiabatic resistive calorimeter (SARC) 1 with ohm heating of the sample 20, which measures the heating enthalpy and is formed of an inner cylinder 11 and a couple of pistons 15 and 16, thus forming said elements a cylindrical chamber hermetically closed 10, which avoids that during its operation can be material losses by leaks. Pistons 15 and 16 have, in one of their ends an electrode 31 and 36 respectively and they pass the electrical heating flow through the sample 20. In reference to this electric flow, the applied power is calculated and therefore, the supplied heat to the sample 20, which is equal to the specific enthalpy. To assure that the whole of the electric flow is conducted through the sample 20, the inner cylinder 11 is electrically isolated. The SARC 1 with ohm heating of the sample 20 is formed additionally of a spring with which the pressure of the experiment can be controlled and of instruments that include actuators 60, sensors and the necessary conditioning to make available in a computer 81, added to the calorimeter, the control objects and the controlled variables.

IPC Classes  ?

• G01K 17/00 - Measuring quantity of heat
• G01N 25/48 - Investigating or analysing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation

Abstract

The invention relates to a method of using a bipolar transistor as a self-calibrated thermometer and/or temperature sensor, which is immune to errors generated by parasitic elements such as ideality factors or resistances, and to the development thereof. According to the invention, the collector current values, ICmi as a function of direct base-emitter voltage VEbmi, are plotted in the form of the product ICmi(VEBmi) x exp(-qVEBmi/kT0), as a function of bas-emitter voltage VEB. T0 is a parameter which ensures that a region of the aforementioned graph has zero slope, while simultaneously representing the absolute temperature of the transistor at the moment at which the collector current ICmi is obtained as a function of voltage VEbmi.

IPC Classes  ?

• G01K 7/01 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using semiconducting elements having PN junctions