This invention features methods and devices for ameliorating implant-induced inflammation and for reducing the risk of fibrosis. The methods and devices include a substrate coated with P-15 peptide positioned at the site of implantation.
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
Orthopedic prosthetic and filling materials used in spinal or orthopedic surgery, or in treatment of bone trauma, namely, artificial bone void fillers and bone graft putties for use in the replacement or grafting of bones
Orthopedic prosthetic and filling materials used in spinal or orthopedic surgery, or in treatment of bone trauma, namely, artificial bone void fillers and bone graft putties for use in the replacement or grafting of bones
Orthopedic prosthetic and filling materials used in spinal or orthopedic surgery, or in treatment of bone trauma, namely, artificial bone void fillers and bone graft putties for use in the replacement or grafting of bones
5.
DEVICES AND METHODS FOR AMELIORATING IMPLANT-INDUCED INFLAMMATION
This invention features methods and devices for ameliorating implant-induced inflammation and for reducing the risk of fibrosis. The methods and devices include a substrate coated with P-15 peptide positioned at the site of implantation.
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61L 27/00 - Materials for prostheses or for coating prostheses
Prosthetic and filling materials, namely, artificial
materials for use in the replacement or grafting of bone;
orthopedic prosthetic and filling materials used in spinal
or orthopedic surgery, or in treatment of bone trauma,
namely, artificial bone void fillers and bone graft
materials for use in the replacement or grafting of bone.
(1) Prosthetic and filling materials, namely, artificial materials for use in the replacement or grafting of bone, being bone void fillers and putties comprised of artificial materials.
(2) Orthopedic prosthetic and filling materials used in spinal or orthopedic surgery, or in treatment of bone trauma, namely, artificial bone void fillers and bone graft materials for use in the replacement or grafting of bone, being bone void fillers and putties comprised of proteins, minerals, collagen, biologic bone graft made of P-15 osteogenic cell binding peptide, and artificial materials
Prosthetic and filling materials, namely, bone void fillers consisting of artificial materials for use in the replacement or grafting of bone; orthopedic prosthetic and filling materials used in spinal or orthopedic surgery, or in treatment of bone trauma, namely, artificial bone void fillers and bone graft materials consisting of artificial materials for use in the replacement or grafting of bone.
(1) Prosthetic and filling materials, namely, biologic bone graft made of P-15 osteogenic cell binding peptide, orthopaedic joint implants made from artificial materials, medical, surgical and orthopaedic implants made of artificial materials, bone implants made from artificial materials, and osseous implants made of artificial materials, all for use in the replacement or grafting of bone; orthopedic prosthetic and filling materials used in spinal or orthopedic surgery, or in treatment of bone trauma, namely, bone void fillers comprised of artificial materials, and spinal implants composed of artificial material, implants for use in bone grafting, bone implants made of artificial materials, orthopedic bone implants, artificial bone parts to be implanted in natural bones, synthetic polymer and chemical monomer for filling the void in bones, artificial bones for implantation, and bone substitutes for surgical use, all for use in the replacement or grafting of bone.
Prosthetic and filling materials, namely, artificial materials for use in the replacement or grafting of bone; Orthopedic prosthetic and filling materials used in spinal or orthopedic surgery, or in treatment of bone trauma, namely, artificial bone void fillers and bone graft materials for use in the replacement or grafting of bone
Orthopedic prosthetic and filling materials used in spinal or orthopedic surgery, or in treatment of bone trauma, namely, artificial bone void fillers and bone graft putties for use in the replacement or grafting of bones
The invention features methods and compositions for (i) controlling the amount of peptide bound to calcium phosphate particles; and (ii) for tightly binding peptide to the surface of calcium phosphate particles. The methods and compositions can be useful for preparing implants useful for promoting bone deposition at the site of implantation, and for repairing a variety of orthopedic conditions.
A method of coating a peptide or protein useful for improving the cellular activity related to bone growth on an inorganic particle comprises the steps of freezing the residual liquid present on uncoated and or coated inorganic particles, and drying the uncoated or coated inorganic particles after freezing the residual liquid, the drying comprising causing the frozen residual liquid to sublime under vacuum. Further disclosed embodiments of the invention include further processes for forming inorganic particles coated with a peptide or protein useful for improving cellular activity related to bone growth and medical devices comprising the coated particles.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
The invention features methods and compositions for (i) controlling the amount of peptide bound to calcium phosphate particles; and (ii) for tightly binding peptide to the surface of calcium phosphate particles. The methods and compositions can be useful for preparing implants useful for promoting bone deposition at the site of implantation, and for repairing a variety of orthopedic conditions.
The present invention relates to antibodies that bind to a polypeptide at an epitope in the amino acid sequence of SEQ ID NO: 1 (e.g., a sericin polypeptide). The invention also provides methods and kits using the antibodies of the invention. In some embodiments, the antibody binds to a polypeptide at an epitope in the amino add sequence of SEQ ID NO: 2. In some embodiments, the antibody binds to a polypeptide at an epitope in the amino add sequence of SEQ ID NO: 3. In some embodiments, the polypeptide is a sericin polypeptide (e.g., a sericin isoform 1B polypeptide). In a related aspect, the invention features a method for selectively detecting sericin in a sample.
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
A61L 27/50 - Materials characterised by their function or physical properties
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61L 15/40 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof
Orthopedic prosthetic and filling materials used in spinal or orthopedic surgery, or in treatment of bone trauma, namely, artificial bone void fillers and bone graft putties for use in the replacement or grafting of bones; surgical instruments and apparatus; surgical instruments for use in orthopedic surgery; surgical instruments, namely, orthopedic fixation devices used in orthopedic transplant or implant surgery.
17.
ANTIBODIES TO SERICIN AND METHODS AND KITS USING SAME
The present invention relates to antibodies that bind to a polypeptide at an epitope in the amino acid sequence of SEQ ID NO: 1 (e.g., a sericin polypeptide). The invention also provides methods and kits using the antibodies of the invention. In some embodiments, the antibody binds to a polypeptide at an epitope in the amino add sequence of SEQ ID NO: 2. In some embodiments, the antibody binds to a polypeptide at an epitope in the amino add sequence of SEQ ID NO: 3. In some embodiments, the polypeptide is a sericin polypeptide (e.g., a sericin isoform 1B polypeptide). In a related aspect, the invention features a method for selectively detecting sericin in a sample.
The invention features fiber reinforced bone repair putties and fiber reinforced pliable lyophilized implants which are useful for the treatment of bone defects. The putties and lyophilized implants include ceramic particles. The formulations of the invention can exhibit reduced migration of the ceramic particles, and are mechanically strengthened so the materials can be aggressively manipulated by a physician during an implantation procedure without tearing or puncturing.
A61L 27/58 - Materials at least partially resorbable by the body
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
A61L 27/12 - Phosphorus-containing materials, e.g. apatite
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
The invention features fiber reinforced bone repair putties and fiber reinforced pliable lyophilized implants which are useful for the treatment of bone defects. The putties and lyophilized implants include ceramic particles. The formulations of the invention can exhibit reduced migration of the ceramic particles, and are mechanically strengthened so the materials can be aggressively manipulated by a physician during an implantation procedure without tearing or puncturing.
C08L 79/00 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen, or carbon only, not provided for in groups
C04B 28/14 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing calcium sulfate cements
A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist environment of the body, it will hold its shape well, for an extended time. Because the lyophilized pliable medical device is porous, it adsorbs blood and other beneficial cells containing body fluids, such as bone marrow, contributing to its superior bone repair efficacy in comparison to an analogous putty that has not been lyophilized. In addition these lyophilized pliable medical devices are easier to terminally steam sterilize than the analogous putty because there is no moisture present to boil and “blow-out” of the containment device (syringe). The glycerin that is present in the formulation lends pliability but has a low vapor pressure.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
The invention features compositions including a peptide conjugated to a binding group having affinity for a biocompatible calcified substrate, their use in implantable materials, and for the treatment of orthopedic conditions.
Surgical and medical articles; orthopedic articles, namely bone replacement and bone graft substitute materials for use in spine and orthopedic surgery and treatment of bone trauma.
(1) Surgical instruments for use in orthopedic surgery; orthopedic articles, namely, bone replacement and bone graft substitute materials for use in spine and orthopedic surgery and treatment of bone trauma.
Orthopedic prosthetic and filling materials used in spinal or orthopedic surgery, or in treatment of bone trauma, namely, artificial bone void fillers and bone graft putties for use in the replacement or grafting of bones; [ surgical instruments and apparatus; surgical instruments for use in orthopedic surgery; surgical instruments, namely, orthopedic fixation devices used in orthopedic transplant or implant surgery ]
A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist environment of the body, it will hold its shape well, for an extended time. Because the lyophilized pliable medical device is porous, it adsorbs blood and other beneficial cells containing body fluids, such as bone marrow, contributing to its superior bone repair efficacy in comparison to an analogous putty that has not been lyophilized. In addition these lyophilized pliable medical devices are easier to terminally steam sterilize than the analogous putty because there is no moisture present to boil and “blow-out” of the containment device (syringe). The glycerin that is present in the formulation lends pliability but has a low vapor pressure.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
