Cerion, LLC

United States of America

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        Patent 31
        Trademark 3
Jurisdiction
        United States 24
        Canada 6
        World 4
Date
2022 3
Before 2021 31
IPC Class
C10L 1/12 - Inorganic compounds 12
A61K 9/10 - DispersionsEmulsions 10
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites 10
A61K 33/24 - Heavy metalsCompounds thereof 9
A61K 9/51 - Nanocapsules 9
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NICE Class
01 - Chemical and biological materials for industrial, scientific and agricultural use 3
40 - Treatment of materials; recycling, air and water treatment, 3
42 - Scientific, technological and industrial services, research and design 3

1.

CERION NANOMATERIALS

      
Application Number 1679428
Status Registered
Filing Date 2022-04-05
Registration Date 2022-04-05
Owner Cerion LLC (USA)
NICE Classes  ?
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 40 - Treatment of materials; recycling, air and water treatment,
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

Chemicals for industrial use; inorganic chemical compounds comprised of metal, metal oxide and ceramic nanoparticles. Manufacture of inorganic chemical compounds to the order and specification of others; manufacture of micron, sub-micron and nano scale materials to the order and specification of others for use in the manufacture of other goods; manufacture of nanoparticles to the order and specification of others. Consulting services in the fields of chemical research; chemical engineering; consulting services in the fields of chemical research and development, chemical engineering and process development, and nanoparticle design and scale-up; chemical engineering design consultancy for nanoparticle manufacturing processes.

2.

Edds chelated nanoceria with catalase-like activity

      
Application Number 17546640
Grant Number 11771658
Status In Force
Filing Date 2021-12-09
First Publication Date 2022-03-31
Grant Date 2023-10-03
Owner Cerion, LLC (USA)
Inventor Bell, Eric Leslie

Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, ethylenediaminedisuccinic acid, an oxidant, water, and optionally citric acid, is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of cerium oxide nanoparticles. Biocompatible nanoparticles comprised of cerium oxide, ethylenediaminedisuccinic acid, and optionally citric acid, are described. An increase in catalase-like enzyme activity is demonstrated by cerium oxide nanoparticles prepared with citric acid and ethylenediaminedisuccinic acid.

IPC Classes  ?

  • A61K 9/51 - Nanocapsules
  • A61K 9/10 - DispersionsEmulsions
  • A61K 33/24 - Heavy metalsCompounds thereof
  • A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
  • A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
  • A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 33/244 - LanthanidesCompounds thereof
  • A61K 33/243 - PlatinumCompounds thereof
  • F41C 33/00 - Means for wearing or carrying smallarms
  • F41C 33/04 - Special attachments therefor
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • F41C 33/02 - Holsters, i.e. cases for pistols having means for being carried or worn, e.g. at the belt or under the arm

3.

CERION NANOMATERIALS

      
Serial Number 97265267
Status Registered
Filing Date 2022-02-14
Registration Date 2025-08-19
Owner Cerion LLC ()
NICE Classes  ?
  • 40 - Treatment of materials; recycling, air and water treatment,
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

Manufacture of inorganic chemical compounds to the order and specification of others; Manufacture of micron, sub-micron and nano scale materials to the order and specification of others for use in the manufacture of other goods; Manufacture of nanoparticles to the order and specification of others; Consulting services regarding manufacture of nanoparticles Inorganic chemical compounds comprised of metal, metal oxide and ceramic nanoparticles for industrial purposes Chemical research; Chemical engineering; Consulting services in the fields of chemical research and development, chemical engineering and chemical process development, and nanoparticle design

4.

EDDS chelated nanoceria with catalase-like activity

      
Application Number 15545065
Grant Number 10722474
Status In Force
Filing Date 2016-01-20
First Publication Date 2018-11-15
Grant Date 2020-07-28
Owner Cerion, LLC (USA)
Inventor Bell, Eric Leslie

Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, ethylenediaminedisuccinic acid, an oxidant, water, and optionally citric acid, is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of cerium oxide nanoparticles. Biocompatible, nanoparticles comprised of cerium oxide, ethylenediaminedisuccinic acid, and optionally citric acid, are described. An increase in catalase-like enzyme activity is demonstrated by cerium oxide nanoparticles prepared with citric acid and ethylenediaminedisuccinic acid.

IPC Classes  ?

  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 9/51 - Nanocapsules
  • A61K 9/10 - DispersionsEmulsions
  • A61K 33/24 - Heavy metalsCompounds thereof
  • A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
  • A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
  • A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • F41C 33/00 - Means for wearing or carrying smallarms
  • F41C 33/04 - Special attachments therefor
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • F41C 33/02 - Holsters, i.e. cases for pistols having means for being carried or worn, e.g. at the belt or under the arm

5.

CERION

      
Serial Number 87917997
Status Registered
Filing Date 2018-05-11
Registration Date 2019-05-07
Owner CERION, LLC ()
NICE Classes  ?
  • 40 - Treatment of materials; recycling, air and water treatment,
  • 01 - Chemical and biological materials for industrial, scientific and agricultural use
  • 42 - Scientific, technological and industrial services, research and design

Goods & Services

Manufacture of inorganic chemical compounds to the order and specification of others; Manufacture of micron and nano scale materials to the order and specification of others for use in the manufacture of other goods; manufacture of nanoparticles to the order and specification of others; consulting services in the field of nanoparticle manufacture Chemicals for industrial use; Inorganic chemical compounds for use in the manufacture of additives, antimicrobials, catalysts, ceramics, coatings, conductive inks, optics, [ pharmaceuticals, polishing agents, therapeutics; ] Inorganic nanoparticle chemical compounds for use in the manufacture of additives, antimicrobials, catalysts, ceramics, coatings, conductive inks, optics, [ pharmaceuticals, polishing agents, therapeutics; ] Oxides; Metallic oxides; Zinc oxides; Titanium oxides; Silicon oxides; Iron oxides; Nickel oxides; Zirconium oxides; Cerium oxides; Silver metal nanoparticles used in the manufacture of conductive inks [ ; Chemical slurries for polishing metals, glass, ceramics, semi-conductors, stone, plastics ] Chemical research; chemical engineering; Consulting services in the fields of chemical research and development, chemical engineering and process development

6.

Cobalt oxide nanoparticle preparation

      
Application Number 15542976
Grant Number 10519042
Status In Force
Filing Date 2016-01-12
First Publication Date 2018-01-04
Grant Date 2019-12-31
Owner Cerion, LLC (USA)
Inventor Sandford, David Wallace

Abstract

A method of making stable aqueous dispersions and concentrates of cobalt oxide nanoparticles is described, wherein a reaction mixture comprising cobalt(II) ion, a carboxylic acid, a base, an oxidant and water is formed, and in which cobalt oxide nanoparticles are formed. Cobalt oxide nanoparticles ranging in average crystallite size from about 4 nm to 15 nm are described. The cobalt oxide nanoparticles may be isolated and redispersed to form stable, homogeneous, aqueous dispersions of cobalt oxide nanoparticles containing from about 1 to about 20 weight percent cobalt oxide.

IPC Classes  ?

7.

Chelated nanoceria for the treatment of oxidative stress

      
Application Number 15412694
Grant Number 10751366
Status In Force
Filing Date 2017-01-23
First Publication Date 2017-05-11
Grant Date 2020-08-25
Owner Cerion LLC (USA)
Inventor
  • Stadler, Bradford Michael
  • Sandford, David Wallace

Abstract

A process for making cerium-containing nanoparticles with biocompatible stabilizers is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid, a stabilizer (chelator) selected from the group consisting of nitrilotriacetic acid, ethylene glycol tetraacetic acid and diethylenetriaminepentaacetic acid, and an oxidant, is provided, followed by a heating step to effectively form the nanoparticles. These biocompatible nanoparticles can be used to treat oxidative stress related diseases and events, such as ischemic stroke.

IPC Classes  ?

  • A61K 33/24 - Heavy metalsCompounds thereof
  • C01F 17/206 - Compounds containing only rare earth metals as the metal element oxide or hydroxide being the only anion
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
  • A61K 9/51 - Nanocapsules
  • A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
  • A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
  • A61K 9/10 - DispersionsEmulsions
  • A61K 47/02 - Inorganic compounds

8.

Nanoceria for the treatment of oxidative stress

      
Application Number 15388700
Grant Number 09962406
Status In Force
Filing Date 2016-12-22
First Publication Date 2017-04-13
Grant Date 2018-05-08
Owner CERION, LLC (USA)
Inventor
  • Reed, Kenneth Joseph
  • Costanzo, Wendi Ann
  • Erlichman, Joseph Samuel
  • Bell, Eric Leslie

Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid and ethylenediaminetetraacetic acid in a predetermined ratio, an oxidant, and water is provided along with temperature conditions to directly form, without isolation, a stable dispersion of cerium oxide nanoparticles. These biocompatible cerium oxide nanoparticles may be used to prevent and/or treat oxidative stress related diseases, such as stroke, relapse/remitting multiple sclerosis, chronic-progressive multiple sclerosis, amyotrophic lateral sclerosis, and ischemic reperfusion injury.

IPC Classes  ?

  • A61L 31/16 - Biologically active materials, e.g. therapeutic substances
  • A61K 33/24 - Heavy metalsCompounds thereof
  • B01J 13/02 - Making microcapsules or microballoons
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
  • A61K 9/10 - DispersionsEmulsions
  • A61K 9/51 - Nanocapsules
  • A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
  • A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids

9.

Malic acid stabilized nanoceria particles

      
Application Number 15029672
Grant Number 10143661
Status In Force
Filing Date 2014-10-17
First Publication Date 2016-11-17
Grant Date 2018-12-04
Owner Cerion, LLC (USA)
Inventor Sandford, David Wallace

Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, malic acid, an oxidant, and water, is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of nanoceria particles. Biocompatible nanoparticles comprised of ceria and malic acid are described. A reduction in cell death in a murine model of ischemic stroke utilizing intact brain slices is demonstrated by a prophylactic treatment of ceria nanoparticles prepared with malic acid.

IPC Classes  ?

10.

EDDS CHELATED NANOCERIA WITH CATALASE-LIKE ACTIVITY

      
Application Number US2016014076
Publication Number 2016/118592
Status In Force
Filing Date 2016-01-20
Publication Date 2016-07-28
Owner CERION, LLC (USA)
Inventor Bell, Eric, Leslie

Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, ethylenediaminedisuccinic acid, an oxidant, water, and optionally citric acid, is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of cerium oxide nanoparticles. Biocompatible nanoparticles comprised of cerium oxide, ethylenediaminedisuccinic acid, and optionally citric acid, are described. An increase in catalase-like enzyme activity is demonstrated by cerium oxide nanoparticles prepared with citric acid and ethylenediaminedisuccinic acid.

IPC Classes  ?

  • A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
  • A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 33/00 - Medicinal preparations containing inorganic active ingredients
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/10 - DispersionsEmulsions

11.

COBALT OXIDE NANOPARTICLE PREPARATION

      
Application Number US2016012973
Publication Number 2016/115085
Status In Force
Filing Date 2016-01-12
Publication Date 2016-07-21
Owner CERION, LLC (USA)
Inventor Sandford, David, Wallace

Abstract

A method of making stable aqueous dispersions and concentrates of cobalt oxide nanoparticles is described, wherein a reaction mixture comprising cobalt(II) ion, a carboxylic acid, a base, an oxidant and water is formed, and in which cobalt oxide nanoparticles are formed. Cobalt oxide nanoparticles ranging in average crystallite size from about 4 nm to 15 nm are described. The cobalt oxide nanoparticles may be isolated and redispersed to form stable, homogeneous, aqueous dispersions of cobalt oxide nanoparticles containing from about 1 to about 20 weight percent cobalt oxide.

IPC Classes  ?

12.

Rapid method for production of cerium-containing oxide organic colloids

      
Application Number 14875088
Grant Number 10544376
Status In Force
Filing Date 2015-10-05
First Publication Date 2016-06-16
Grant Date 2020-01-28
Owner Cerion, LLC (USA)
Inventor
  • Prok, Gary Robert
  • Williams, Stephen Charles

Abstract

Improved methods for producing colloidal dispersions of cerium-containing oxide nanoparticles in substantially non-polar solvents are disclosed. The cerium-containing oxide nanoparticles of an aqueous colloid are transferred to a substantially non-polar liquid comprising one or more amphiphilic materials, one or more low-polarity solvents, and, optionally, one or more glycol ether promoter materials. The transfer is achieved by mixing the aqueous and substantially non-polar materials, forming an emulsion, followed by a phase separation into a remnant polar solution phase and a substantially non-polar organic colloid phase. The organic colloid phase is then collected.

IPC Classes  ?

  • C01F 17/00 - Compounds of rare earth metals
  • C10L 1/12 - Inorganic compounds
  • C10L 10/00 - Use of additives to fuels or fires for particular purposes
  • C10L 1/185 - EthersAcetalsKetalsAldehydesKetones
  • C10L 1/188 - Carboxylic acidsSalts thereof
  • C10L 1/10 - Liquid carbonaceous fuels containing additives
  • C10L 1/182 - Organic compounds containing oxygen containing hydroxy groupsSalts thereof
  • C10L 10/02 - Use of additives to fuels or fires for particular purposes for reducing smoke development
  • C01G 49/00 - Compounds of iron
  • C10L 1/18 - Organic compounds containing oxygen
  • C10M 125/10 - Metal oxides, hydroxides, carbonates or bicarbonates
  • C10M 129/16 - Ethers
  • C10M 129/40 - Carboxylic acidsSalts thereof having carboxyl groups bound to acyclic or cycloaliphatic carbon atoms having 8 or more carbon atoms monocarboxylic

13.

Nanoceria for the treatment of oxidative stress

      
Application Number 14690781
Grant Number 09533007
Status In Force
Filing Date 2015-04-20
First Publication Date 2015-08-20
Grant Date 2017-01-03
Owner CERION, LLC (USA)
Inventor
  • Reed, Kenneth Joseph
  • Costanzo, Wendi Ann
  • Erlichman, Joseph Samuel
  • Bell, Eric Leslie

Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid and ethylenediaminetetraacetic acid in a predetermined ratio, an oxidant, and water is provided along with temperature conditions to directly form, without isolation, a stable dispersion of cerium oxide nanoparticles. These biocompatible cerium oxide nanoparticles may be used to prevent and/or treat oxidative stress related diseases, such as stroke, relapse/remitting multiple sclerosis, chronic-progressive multiple sclerosis, amyotrophic lateral sclerosis, and ischemic reperfusion injury.

IPC Classes  ?

  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • A61K 33/24 - Heavy metalsCompounds thereof
  • A61K 9/10 - DispersionsEmulsions
  • B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
  • B01J 13/02 - Making microcapsules or microballoons

14.

Nanoparticles of a metal and a biguanide

      
Application Number 14597678
Grant Number 09433591
Status In Force
Filing Date 2015-01-15
First Publication Date 2015-07-16
Grant Date 2016-09-06
Owner CERION, LLC (USA)
Inventor
  • Reed, Kenneth Joseph
  • Versaggi, Ashley Renée
  • Costanzo, Wendi Ann

Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising a metal ion, a biguanide, an oxidant, and water; optionally further comprising an alpha-amino acid or a nucleobase; is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of metal-containing nanoparticles. Biocompatible nanoparticles comprised of cerium and a biguanide, and optionally containing an alpha-amino acid or a nucleobase, are also described. The use of metal oxide nanoparticles comprising a biguanide as a nanoparticle core/corona in the preparation of nanoscale ionic (liquid) material compositions is disclosed.

IPC Classes  ?

  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
  • A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
  • A61K 33/00 - Medicinal preparations containing inorganic active ingredients
  • A61K 9/51 - Nanocapsules
  • B82Y 40/00 - Manufacture or treatment of nanostructures
  • B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

15.

MALIC ACID STABILIZED NANOCERIA PARTICLES

      
Application Number US2014061044
Publication Number 2015/058037
Status In Force
Filing Date 2014-10-17
Publication Date 2015-04-23
Owner CERION, LLC (USA)
Inventor Sandford, David, Wallace

Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, malic acid, an oxidant, and water, is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of nanoceria particles. Biocompatible nanoparticles comprised of ceria and malic acid are described. A reduction in cell death in a murine model of ischemic stroke utilizing intact brain slices is demonstrated by a prophylactic treatment of ceria nanoparticles prepared with malic acid.

IPC Classes  ?

16.

Method of making cerium oxide nanoparticles

      
Application Number 14537161
Grant Number 09340738
Status In Force
Filing Date 2014-11-10
First Publication Date 2015-03-05
Grant Date 2016-05-17
Owner Cerion, LLC (USA)
Inventor
  • Difrancesco, Albert Gary
  • Hailstone, Richard K.
  • Reed, Kenneth J.
  • Prok, Gary R.

Abstract

2-δ, wherein x has a value from about 0.001 to about 0.95 and δ has a value of about 0.0 to about 0.5.

IPC Classes  ?

  • C01F 17/00 - Compounds of rare earth metals
  • C10L 1/12 - Inorganic compounds
  • B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
  • C01G 25/00 - Compounds of zirconium
  • C01G 25/02 - Oxides
  • C01G 49/00 - Compounds of iron
  • C01G 49/02 - OxidesHydroxides
  • C01G 55/00 - Compounds of ruthenium, rhodium, palladium, osmium, iridium, or platinum
  • C10L 1/10 - Liquid carbonaceous fuels containing additives
  • C10L 10/02 - Use of additives to fuels or fires for particular purposes for reducing smoke development
  • C10L 10/06 - Use of additives to fuels or fires for particular purposes for facilitating soot removal
  • C10L 1/188 - Carboxylic acidsSalts thereof

17.

Method of making cerium oxide nanoparticles

      
Application Number 14537993
Grant Number 09303223
Status In Force
Filing Date 2014-11-11
First Publication Date 2015-03-05
Grant Date 2016-04-05
Owner Cerion, LLC (USA)
Inventor
  • Difrancesco, Albert Gary
  • Hailstone, Richard K.
  • Reed, Kenneth J.
  • Prok, Gary R.

Abstract

2-δ, wherein δ has a value of about 0.0 to about 0.5.

IPC Classes  ?

  • C01G 25/00 - Compounds of zirconium
  • C10L 1/12 - Inorganic compounds
  • B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
  • C01F 17/00 - Compounds of rare earth metals
  • C10G 25/02 - Refining of hydrocarbon oils, in the absence of hydrogen, with solid sorbents with ion-exchange material
  • C01G 49/00 - Compounds of iron
  • C01G 49/02 - OxidesHydroxides
  • C01G 55/00 - Compounds of ruthenium, rhodium, palladium, osmium, iridium, or platinum
  • C10L 1/10 - Liquid carbonaceous fuels containing additives
  • C10L 10/02 - Use of additives to fuels or fires for particular purposes for reducing smoke development
  • C10L 10/06 - Use of additives to fuels or fires for particular purposes for facilitating soot removal
  • C10L 1/188 - Carboxylic acidsSalts thereof

18.

Nanoparticles of a metal and a nucleobase

      
Application Number 14456197
Grant Number 09623110
Status In Force
Filing Date 2014-08-11
First Publication Date 2015-02-12
Grant Date 2017-04-18
Owner CERION, LLC (USA)
Inventor
  • Versaggi, Ashley Renée
  • Costanzo, Wendi Ann
  • Reed, Kenneth Joseph

Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising a metal ion, a nucleobase, an oxidant, and water, is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of nanoparticles. Biocompatible nanoparticles comprised of cerium or iron as the metal ion, and a purine and/or a pyrimidine as the nucleobase, are described.

IPC Classes  ?

  • A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
  • A61K 9/10 - DispersionsEmulsions
  • A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
  • A61K 47/02 - Inorganic compounds
  • A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes

19.

Chelated nanoceria for the treatment of oxidative stress

      
Application Number 14261756
Grant Number 09549950
Status In Force
Filing Date 2014-04-25
First Publication Date 2014-10-30
Grant Date 2017-01-24
Owner CERION, LLC (USA)
Inventor
  • Stadler, Bradford Michael
  • Sandford, David Wallace

Abstract

A process for making cerium-containing nanoparticles with biocompatible stabilizers is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid, a stabilizer (chelator) selected from the group consisting of nitrilotriacetic acid, ethylene glycol tetraacetic acid and diethylenetriaminepentaacetic acid, and an oxidant, is provided, followed by a heating step to effectively form the nanoparticles. These biocompatible nanoparticles can be used to treat oxidative stress related diseases and events, such as ischemic stroke.

IPC Classes  ?

  • A61K 33/24 - Heavy metalsCompounds thereof
  • A61K 9/51 - Nanocapsules
  • A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
  • A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
  • C01F 17/00 - Compounds of rare earth metals
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

20.

Nanoceria for the treatment of oxidative stress

      
Application Number 13836827
Grant Number 09034392
Status In Force
Filing Date 2013-03-15
First Publication Date 2013-12-19
Grant Date 2015-05-19
Owner CERION, LLC (USA)
Inventor
  • Reed, Kenneth Joseph
  • Costanzo, Wendi Ann
  • Erlichman, Joseph Samuel
  • Bell, Eric Leslie

Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid and ethylenediaminetetraacetic acid in a predetermined ratio, an oxidant, and water is provided along with temperature conditions to directly form, without isolation, a stable dispersion of cerium oxide nanoparticles. These biocompatible cerium oxide nanoparticles may be used to prevent and/or treat oxidative stress related diseases, such as stroke, relapse/remitting multiple sclerosis, chronic-progressive multiple sclerosis, amyotrophic lateral sclerosis, and ischemic reperfusion injury.

IPC Classes  ?

  • A61K 33/24 - Heavy metalsCompounds thereof
  • B01J 13/02 - Making microcapsules or microballoons
  • A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
  • B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
  • A61K 9/10 - DispersionsEmulsions
  • A61K 9/51 - Nanocapsules

21.

Nanoceria with citric acid additive

      
Application Number 13838332
Grant Number 09446070
Status In Force
Filing Date 2013-03-15
First Publication Date 2013-12-19
Grant Date 2016-09-20
Owner CERION, LLC (USA)
Inventor
  • Costanzo, Wendi Ann
  • Reed, Kenneth Joseph

Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid, an oxidant, and water, is adjusted to a predetermined range of pH, held at temperature conditions to directly form, without isolation, a stable dispersion of cerium oxide nanoparticles. Dispersions of these biocompatible cerium oxide nanoparticles exhibit self-life well in excess of one year, and may be used to prevent and/or treat disease or injury, such as oxidative stress related diseases and events.

IPC Classes  ?

22.

Iron oxide nanoparticle dispersions and fuel additives for soot combustion

      
Application Number 13902156
Grant Number 10000714
Status In Force
Filing Date 2013-05-24
First Publication Date 2013-12-19
Grant Date 2018-06-19
Owner CERION LLC (USA)
Inventor
  • Irving, Lyn Marie
  • Sandford, David Wallace
  • Difrancesco, Albert Gary
  • Hailstone, Richard Kenneth

Abstract

Aqueous and substantially crystalline iron oxide nanoparticle dispersions and processes for making them are disclosed. The nanoparticle size and size distribution width are advantageous for use in a fuel additive for catalytic reduction of soot combustion in diesel particulate filters. Nanoparticles of the aqueous colloid are transferred to a substantially non-polar liquid comprising a carboxylic acid and one or more low-polarity solvents. The transfer is achieved by mixing the aqueous and substantially non-polar materials, forming an emulsion, followed by a phase separation into a substantially metal-free remnant polar phase and a substantially non-polar organic colloid phase. A method for rapid and substantially complete transfer of non-agglomerated nanoparticles to the low polarity phase in the presence of an organic amine, and a rapid phase separation of the substantially non-polar colloid from a remnant aqueous phase, are provided.

IPC Classes  ?

  • C10L 10/06 - Use of additives to fuels or fires for particular purposes for facilitating soot removal
  • B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
  • C01G 49/02 - OxidesHydroxides
  • C10L 1/10 - Liquid carbonaceous fuels containing additives
  • C10L 1/12 - Inorganic compounds
  • C10L 10/02 - Use of additives to fuels or fires for particular purposes for reducing smoke development
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
  • C10L 1/16 - Hydrocarbons
  • C10L 1/188 - Carboxylic acidsSalts thereof
  • C10L 1/222 - Organic compounds containing nitrogen containing at least one carbon-to-nitrogen single bond

23.

IRON OXIDE NANOPARTICLE DISPERSIONS AND FUEL ADDITIVES FOR SOOT COMBUSTION

      
Document Number 02873474
Status In Force
Filing Date 2013-05-24
Open to Public Date 2013-11-28
Grant Date 2020-09-22
Owner CERION LLC (USA)
Inventor
  • Irving, Lyn Marie
  • Sandford, David Wallace
  • Difrancesco, Albert Gary
  • Hailstone, Richard Kenneth

Abstract

Aqueous and substantially crystalline iron oxide nanoparticle dispersions and processes for making them are disclosed. The nanoparticle size and size distribution width are advantageous for use in a fuel additive for catalytic reduction of soot combustion in diesel particulate filters. Nanoparticles of the aqueous colloid are transferred to a substantially non-polar liquid comprising a carboxylic acid and one or more low-polarity solvents. The transfer is achieved by mixing the aqueous and substantially non-polar materials, forming an emulsion, followed by a phase separation into a substantially metal-free remnant polar phase and a substantially non-polar organic colloid phase. A method for rapid and substantially complete transfer of non-agglomerated nanoparticles to the low polarity phase in the presence of an organic amine, and a rapid phase separation of the substantially non-polar colloid from a remnant aqueous phase, are provided.

IPC Classes  ?

  • B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
  • B01J 13/08 - Simple coacervation, i.e. addition of highly hydrophilic material
  • C01G 49/02 - OxidesHydroxides
  • C10L 1/10 - Liquid carbonaceous fuels containing additives
  • C10L 1/12 - Inorganic compounds
  • C10L 1/16 - Hydrocarbons
  • C10L 1/188 - Carboxylic acidsSalts thereof
  • C10L 1/222 - Organic compounds containing nitrogen containing at least one carbon-to-nitrogen single bond
  • C10L 10/02 - Use of additives to fuels or fires for particular purposes for reducing smoke development
  • C10L 10/06 - Use of additives to fuels or fires for particular purposes for facilitating soot removal

24.

Process for making cerium dioxide nanoparticles

      
Application Number 13865858
Grant Number 09221032
Status In Force
Filing Date 2013-04-18
First Publication Date 2013-09-05
Grant Date 2015-12-29
Owner CERION, LLC (USA)
Inventor
  • Reed, Kenneth
  • Difrancesco, Albert Gary

Abstract

A method of improving the efficiency of a diesel engine provided with a source of diesel fuel includes the steps of: a) adding to the diesel fuel a reverse-micellar composition having an aqueous first disperse phase that includes a free radical initiator and a first continuous phase that includes a first hydrocarbon liquid, a first surfactant, and optionally a co-surfactant, thereby producing a modified diesel fuel, and b) operating the engine, thereby combusting the modified diesel fuel. The efficiency of a diesel engine provided with a source of diesel fuel and a source of lubricating oil can also be improved by modifying the lubricating oil by the addition of a stabilized nanoparticulate composition of cerium dioxide. The efficiency of a diesel engine can also be improved by adding to the diesel fuel a reverse-micellar composition that includes an aqueous disperse phase containing boric acid or a borate salt.

IPC Classes  ?

  • B01J 23/10 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of rare earths
  • B01F 3/08 - Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed liquids with liquids; Emulsifying
  • B01F 7/16 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a vertical axis
  • B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
  • C10L 1/10 - Liquid carbonaceous fuels containing additives
  • C10L 10/02 - Use of additives to fuels or fires for particular purposes for reducing smoke development
  • C10L 10/08 - Use of additives to fuels or fires for particular purposes for improving lubricityUse of additives to fuels or fires for particular purposes for reducing wear
  • C10L 10/12 - Use of additives to fuels or fires for particular purposes for improving the cetane number
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
  • C10L 1/12 - Inorganic compounds
  • C10L 1/16 - Hydrocarbons
  • C10L 1/18 - Organic compounds containing oxygen
  • C10L 1/182 - Organic compounds containing oxygen containing hydroxy groupsSalts thereof
  • C10L 1/188 - Carboxylic acidsSalts thereof
  • C10L 1/19 - Esters
  • C10L 1/198 - Macromolecular compounds obtained otherwise than by reactions involving only carbon-to-carbon unsaturated bonds
  • C10L 1/222 - Organic compounds containing nitrogen containing at least one carbon-to-nitrogen single bond
  • C10L 1/24 - Organic compounds containing sulfur, selenium or tellurium

25.

IMPROVED METHOD FOR PRODUCTION OF STABLE CERIUM OXIDE ORGANIC COLLOIDS

      
Document Number 02862337
Status In Force
Filing Date 2013-01-30
Open to Public Date 2013-08-08
Grant Date 2020-03-31
Owner CERION LLC (USA)
Inventor
  • Prok, Gary Robert
  • Williams, Stephen Charles

Abstract

An improved process for producing substantially non-polar doped or un-doped cerium oxide nanoparticle dispersions is disclosed. The cerium-containing oxide nanoparticles of an aqueous colloid are transferred to a substantially non-polar liquid comprising one or more amphiphilic materials, one or more low-polarity solvents, and one or more glycol ether promoter materials. The transfer is achieved by mixing the aqueous and substantially non-polar materials, forming an emulsion, followed by a phase separation into a remnant polar solution phase and a substantially non-polar organic colloid phase. The organic colloid phase is then collected. The promoter functions to speed the transfer of nanoparticles to the low-polarity phase. The promoter accelerates the phase separation, and also provides improved colloidal stability of the final substantially non-polar colloidal dispersion. Importantly, the glycol ether promoter reduces the temperature necessary to achieve the phase separation, while providing high extraction yield of nanoparticles into the low-polarity organic phase.

IPC Classes  ?

  • B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons

26.

RAPID METHOD FOR PRODUCTION OF CERIUM-CONTAINING OXIDE ORGANIC COLLOIDS

      
Document Number 02862356
Status In Force
Filing Date 2013-02-01
Open to Public Date 2013-08-08
Grant Date 2020-04-07
Owner CERION LLC (USA)
Inventor
  • Prok, Gary Robert
  • Williams, Stephen Charles

Abstract

A rapid process for producing substantially non-polar cerium and iron containing oxide nanoparticle dispersions is disclosed. The nanoparticles of an acidic aqueous colloid are transferred to a substantially non-polar liquid comprising a carboxylic acid. The transfer is achieved by mixing the aqueous and substantially non-polar liquid comprising particular carboxylic acids, forming an emulsion, optionally adding a low-polarity or non-polar solvent, followed by a phase separation into a remnant polar solution phase and a substantially non- polar organic colloid phase. The organic colloid phase is then collected. The carboxylic acid causes rapid and substantially complete transfer of nanoparticles to the low polarity phase with phase separation of the substantially non-polar colloid from the remnant aqueous phase. It also provides excellent colloidal stability of the final substantially non-polar colloidal dispersion. Importantly, the carboxylic acid reduces the temperature necessary to achieve the rapid phase separation, while providing high extraction yield of nanoparticles into the substantially non- polar organic phase.

IPC Classes  ?

  • C10L 1/12 - Inorganic compounds
  • C10L 10/00 - Use of additives to fuels or fires for particular purposes
  • C10L 10/06 - Use of additives to fuels or fires for particular purposes for facilitating soot removal

27.

Method for production of stable cerium oxide organic colloids

      
Application Number 13753992
Grant Number 09669375
Status In Force
Filing Date 2013-01-30
First Publication Date 2013-08-01
Grant Date 2017-06-06
Owner CERION, LLC (USA)
Inventor
  • Prok, Gary Robert
  • Williams, Stephen Charles

Abstract

An improved process for producing substantially non-polar doped or un-doped cerium oxide nanoparticle dispersions is disclosed. The cerium-containing oxide nanoparticles of an aqueous colloid are transferred to a substantially non-polar liquid comprising one or more amphiphilic materials, one or more low-polarity solvents, and one or more glycol ether promoter materials. The transfer is achieved by mixing the aqueous and substantially non-polar materials, forming an emulsion, followed by a phase separation into a remnant polar solution phase and a substantially non-polar organic colloid phase. The organic colloid phase is then collected. The promoter functions to speed the transfer of nanoparticles to the low-polarity phase. The promoter accelerates the phase separation, and also provides improved colloidal stability of the final substantially non-polar colloidal dispersion. Importantly, the glycol ether promoter reduces the temperature necessary to achieve the phase separation, while providing high extraction yield of nanoparticles into the low-polarity organic phase.

IPC Classes  ?

  • B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons

28.

Structured catalytic nanoparticles and method of preparation

      
Application Number 13583809
Grant Number 09415373
Status In Force
Filing Date 2011-03-08
First Publication Date 2013-05-02
Grant Date 2016-08-16
Owner CERION, LLC (USA)
Inventor
  • Reed, Kenneth J.
  • Difrancisco, Albert Gary
  • Hailstone, Richard K.
  • Prok, Gary R.
  • Allston, Thomas D.

Abstract

A method of making a structured, doped, cerium oxide nanoparticle includes (a) forming a first reaction mixture including cerium(III), an optional metal ion other than cerium, a base, a stabilizer, and a solvent, (b) contacting the first reaction mixture with an oxidant, (c) forming a cerium oxide nanoparticle core by heating the product of step (b), (d) forming a second reaction mixture by combining with the first reaction mixture one or more metal ions other than cerium, and an optional additional quantity of cerium(III), and (e) forming a shell surrounding the core of cerium oxide by heating the second reaction mixture to produce a product dispersion of structured cerium oxide nanoparticles.

IPC Classes  ?

  • B01J 23/10 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of rare earths
  • B01J 23/00 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group
  • B01J 23/83 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with rare earths or actinides
  • B01J 37/02 - Impregnation, coating or precipitation
  • B01J 37/03 - PrecipitationCo-precipitation
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
  • C01G 49/00 - Compounds of iron
  • C10L 1/12 - Inorganic compounds
  • C10L 10/02 - Use of additives to fuels or fires for particular purposes for reducing smoke development
  • C10M 125/10 - Metal oxides, hydroxides, carbonates or bicarbonates
  • C01F 17/00 - Compounds of rare earth metals
  • B82Y 40/00 - Manufacture or treatment of nanostructures

29.

Fuel additive containing lattice engineered cerium dioxide nanoparticles

      
Application Number 13140648
Grant Number 10435639
Status In Force
Filing Date 2008-12-17
First Publication Date 2012-05-24
Grant Date 2019-10-08
Owner Cerion, LLC (USA)
Inventor
  • Difrancesco, Albert Gary
  • Allston, Thomas D.
  • Hailstone, Richard K.
  • Langner, Andreas
  • Reed, Kenneth J.

Abstract

2, wherein “x” has a value from about 0.3 to about 0.8. The nanoparticles thus obtained have a cubic fluorite structure, a mean hydrodynamic diameter in the range of about 1 nm to about 10 nm, and a geometric diameter of less than about 4 nm. The transition metal-containing crystalline cerium dioxide nanoparticles can be used to prepare a dispersion of the particles in a nonpolar medium.

IPC Classes  ?

  • C10L 1/12 - Inorganic compounds
  • B01J 23/00 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group
  • C10M 103/06 - Metal compounds
  • C10M 177/00 - Special methods of preparation of lubricating compositionsChemical modification by after-treatment of components or of the whole of a lubricating composition, not covered by other classes
  • B01J 37/03 - PrecipitationCo-precipitation
  • B01J 23/10 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of rare earths
  • B01J 23/83 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with rare earths or actinides
  • B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

30.

METHOD FOR PRODUCING CERIUM - CONTAINING NANOPARTICLES

      
Document Number 02798986
Status In Force
Filing Date 2011-05-13
Open to Public Date 2011-11-17
Grant Date 2019-08-13
Owner CERION LLC (USA)
Inventor
  • Reed, Kenneth J.
  • Difrancisco, Albert Gary
  • Prok, Gary R.
  • Hailstone, Richard K.

Abstract

A process for making cerium-containing oxide nanoparticles includes providing an aqueous reaction mixture containing a source of cerous ion, optionally a source of one or more metal ions (M) other than cerium, a source of hydroxide ion, at least one monoether carboxylic acid nanoparticle stabilizer wherein the molar ratio of said monoether carboxylic acid nanoparticle stabilizers to total metal ions is greater than 0.2, and an oxidant at an initial temperature in the range of about 20.degree.C to about 100.degree.C. Temperature conditions are provided effective to enable oxidation of cerous ion to ceric ion, thereby forming a product dispersion of cerium-containing oxide nanoparticles, optionally containing one or more metal ions (M), Ce1-x M x O2-.delta., wherein "x" has a value from about 0.0 to about 0.95. The nanoparticles may have a mean hydrodynamic diameter from about 1 nm to about 50 nm, and a geometric diameter of less than about 45 nm.

IPC Classes  ?

  • C01F 17/10 - Preparation or treatment, e.g. separation or purification
  • C01F 17/235 - Cerium oxides or hydroxides
  • C10L 10/00 - Use of additives to fuels or fires for particular purposes

31.

STRUCTURED CATALYTIC NANOPARTICLES AND METHOD OF PREPARATION

      
Document Number 02792409
Status In Force
Filing Date 2011-03-08
Open to Public Date 2011-09-15
Grant Date 2021-04-13
Owner CERION LLC (USA)
Inventor
  • Reed, Kenneth J.
  • Difrancisco, Albert Gary
  • Hailstone, Richard K.
  • Prok, Gary R.
  • Allston, Thomas D.

Abstract

A method for forming a structured doped cerium oxide nanoparticle including the steps of forming a first aqueous cerium(lll) reaction mixture, with optional metal/s other than cerium, a base, and a stabilizer; introducing an oxidant to singly oxidize cerium (III), followed by thermal formation of a doped cerium oxide nanoparticle core; then providing a second reaction mixture of one or more metal ions other than cerium, and optionally cerium (III) ions and sufficient cerium (III) oxidant, followed by thermally converting the mixture into a shell around the doped cerium oxide nanoparticle core, wherein the ratio of metal ions in the core differs from the ratio of metal ions in the shell. The disclosed structured doped cerium oxide nanoparticle may exhibit cubic fluorite crystal structure and possess a diameter in the range 1 nm-20 nm. A dispersion of the developed nanoparticle may be used as a fuel additive.

IPC Classes  ?

  • B22F 9/16 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes
  • C10L 1/12 - Inorganic compounds
  • C10M 125/10 - Metal oxides, hydroxides, carbonates or bicarbonates

32.

Method of preparing cerium dioxide nanoparticles

      
Application Number 12440165
Grant Number 09993803
Status In Force
Filing Date 2007-09-04
First Publication Date 2011-03-10
Grant Date 2018-06-12
Owner CERION, LLC (USA)
Inventor
  • Difrancesco, Albert Gary
  • Hailstone, Richard K.
  • Langner, Andreas
  • Reed, Kenneth J.

Abstract

A method of making cerium dioxide nanoparticles includes: a) providing an aqueous reaction mixture having a source of cerous ion, a source of hydroxide ion, a nanoparticle stabilizer, and an oxidant at an initial temperature no higher than about 20° C.; b) mechanically shearing the mixture and causing it to pass through a perforated screen, thereby forming a suspension of cerium hydroxide nanoparticles; and c) raising the initial temperature to achieve oxidation of cerous ion to eerie ion and thereby form cerium dioxide nanoparticles having a mean diameter in the range of about 1 nm to about 15 nm. The cerium dioxide nanoparticles may be formed in a continuous process.

IPC Classes  ?

  • B01J 23/10 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of rare earths
  • B01F 3/08 - Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed liquids with liquids; Emulsifying
  • B01F 7/16 - Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a vertical axis
  • B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
  • C10L 1/10 - Liquid carbonaceous fuels containing additives
  • C10L 10/02 - Use of additives to fuels or fires for particular purposes for reducing smoke development
  • C10L 10/08 - Use of additives to fuels or fires for particular purposes for improving lubricityUse of additives to fuels or fires for particular purposes for reducing wear
  • C10L 10/12 - Use of additives to fuels or fires for particular purposes for improving the cetane number
  • B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
  • C10L 1/12 - Inorganic compounds
  • C10L 1/16 - Hydrocarbons
  • C10L 1/18 - Organic compounds containing oxygen
  • C10L 1/182 - Organic compounds containing oxygen containing hydroxy groupsSalts thereof
  • C10L 1/188 - Carboxylic acidsSalts thereof
  • C10L 1/19 - Esters
  • C10L 1/198 - Macromolecular compounds obtained otherwise than by reactions involving only carbon-to-carbon unsaturated bonds
  • C10L 1/222 - Organic compounds containing nitrogen containing at least one carbon-to-nitrogen single bond
  • C10L 1/24 - Organic compounds containing sulfur, selenium or tellurium

33.

Process for solvent shifting a nanoparticle dispersion

      
Application Number 12549776
Grant Number 08679344
Status In Force
Filing Date 2009-08-28
First Publication Date 2010-06-17
Grant Date 2014-03-25
Owner CERION, LLC (USA)
Inventor
  • Allston, Thomas D.
  • Herder, Laura M.
  • Langner, Andreas
  • Reed, Kenneth J.

Abstract

A process for replacing the continuous phase of a nanoparticle dispersion with a less polar phase, includes filtering the dispersion through a semi-permeable membrane filter to remove the continuous phase, and introducing a less polar phase.

IPC Classes  ?

  • B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
  • B01F 17/00 - Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
  • C01B 13/14 - Methods for preparing oxides or hydroxides in general
  • C10L 1/12 - Inorganic compounds

34.

METHOD OF CONDITIONING AN INTERNAL COMBUSTION ENGINE

      
Document Number 02839886
Status In Force
Filing Date 2007-09-04
Open to Public Date 2008-03-13
Grant Date 2017-11-28
Owner CERION LLC (USA)
Inventor Reed, Kenneth J.

Abstract


The efficiency of a diesel engine provided with a source of diesel fuel and a
source of lubricating oil can be improved by modifying the lubricating oil by
the addition
of a stabilized nanoparticulate composition of cerium dioxide. There is
provided a
method of making a suspension of cerium dioxide nanoparticles comprising the
steps of:
a. providing an aqueous reaction mixture comprising a source of cerous
ions, a source of hydroxide ion, at least one nanoparticle stabilizer, and an
oxidantat a
temperature effective to generate small nuclei size and to oxidize cerous ion
to ceric ion;
and
b. subjecting the reaction mixture to mechanical shearing, thereby forming
a suspension of cerium dioxide nanoparticles haying a mean hydrodynamic
diameter
ranging from 2 nm to 15 nm.
The at least one nanoparticle stabilizer is selected from the group consisting
of
alkoxysubstituted carboxylic acids, .alpha.-hydroxyl carboxylic acids, pyruvic
acid, and
polyacids.

IPC Classes  ?

  • C09C 1/00 - Treatment of specific inorganic materials other than fibrous fillers Preparation of carbon black
  • C10L 10/02 - Use of additives to fuels or fires for particular purposes for reducing smoke development
  • C10L 10/08 - Use of additives to fuels or fires for particular purposes for improving lubricityUse of additives to fuels or fires for particular purposes for reducing wear
  • C10M 125/10 - Metal oxides, hydroxides, carbonates or bicarbonates