Disclosed herein is a material for use in sorbent-based dialysis, the material comprising: acidic and/or neutral cation exchange particles; alkaline anion exchange particles; and one or more of an alkali metal carbonate, a water insoluble alkaline earth metal carbonate, and a water insoluble polymeric ammonium carbonate. Also disclosed herein are uses of said material and its preparation.
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
B01J 20/04 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
Disclosed herein are dialysate bags, and systems and methods involving the dialysate bags. The dialysate bag comprises a first inlet/outlet port; a second inlet/outlet port; and an inner chamber comprising a peritoneal dialysate concentrate, the inner chamber being fluidly connected to the first and second inlet/outlet ports, wherein the first and second inlet/outlet ports have an open state and a closed state, when in the open state each of the first and second inlet/outlet ports fluidly connect the inner chamber to an exterior of the dialysate bag, and when in the closed state each of the first and second inlet/outlet ports fluidly isolates the inner chamber from the exterior of the dialysate bag.
The present disclosure generally relates to a system for providing dialysate to a patient The system comprises a dialysis cycler and a drain line. The drain line comprises sensors for detecting properties of fluid and a sensor bypass line. The dialysis cycler comprises at least one fluid port that is fluidly connectable to a source of dialysate. The system comprises fluid connections and valves, and the dialysis cycler is configured together with the fluid connections and valves to selectively control flow along a plurality of fluid flow paths through the dialysis cycler, drain line, sensors, and/or sensor bypass line. Also disclosed herein is a device for providing sterile purified water.
The present invention provides urease formulations suitable for use in dialysis, the urease formulations comprise urease, a non-reducing sugar, an antioxidant, a buffer, and a non-ionic surfactant. The urease formulations of the invention have excellent stability against gamma ray sterilisation and excellent shelf life.
The present disclosure generally relates to a sterilization device (200) for sterilizing a fluidic connector (300) for use with a dialysis apparatus. The sterilization device (200) comprises: a housing (210) for holding the fluidic connector (300); an adaptor (220) for connecting the fluidic connector (300) to enable fluid communication between the fluidic connector (300) and the dialysis apparatus while the adaptor (220) and fluidic connector (300) remain inside the housing (210); and broadband ultraviolet chip units (400) disposed in the housing (210), the broadband ultraviolet chip units (400) configured for emitting broadband ultraviolet radiation towards the adaptor (220) in the housing (210). The adaptor (220) is transmissive to the broadband ultraviolet radiation such that the broadband ultraviolet radiation enables sterilization of external and internal surfaces of the adaptor (220) and sterilization of the fluidic connector (300) that is connected into the adaptor (220).
The present disclosure generally relates to a device (200) for detecting infection in a patient (102) undergoing peritoneal dialysis. The device (200) comprises: a housing module (202) removably coupleable to a fluidic element (204) configured for receiving waste dialysate fluid (130) from the patient (102); a set of lighting elements (206) disposed on the housing module (202) and configured for emitting light into the fluidic element (204); a set of optical sensors (208) disposed on the housing module (202) and configured for measuring optical properties of the light that has interacted with the waste dialysate fluid (130) in the fluidic element (204); and a control module configured for measuring turbidity of the waste dialysate fluid (130) based on the optical properties, wherein the dialysate turbidity is indicative of infection in the patient (102) if the dialysate turbidity and historical dialysate turbidity of the patient (102) satisfy a set of predefined conditions.
Disclosed herein is a method of removing fluid from a subject, using the steps of (i) administering a first hypertonic solution comprising a sugar-based osmotic agent to a peritoneal cavity in the subject; (ii) allowing water from the subject to pass into the peritoneal cavity by osmosis, thereby forming a second hypertonic solution within the peritoneal cavity, the second hypertonic solution having a lower concentration of the sugar-based osmotic agent than the first hypertonic solution; (iii) withdrawing a portion of the second hypertonic solution from the peritoneal cavity and combining the withdrawn second hypertonic solution with a sugar concentrate to form a third hypertonic solution; (iv) administering the third hypertonic solution to the peritoneal cavity to form a fourth hypertonic solution within the peritoneal cavity by mixing of the second and third hypertonic solutions; and (v) repeating steps (ii) to (iv) for a desired treatment time. Also disclosed herein is an apparatus suitable for use with the method.
Disclosed herein is a sorbent cartridge comprising: a first layer comprising activated carbon; and a second layer in direct contact with the first layer, the second layer comprising one or both of hydrous zirconium oxide and zirconium phosphate, wherein: the first layer has a moisture content of X wt. %; the second layer has a moisture content of Y wt. %; and the difference in the moisture content of the first layer and the second layer is less than or equal to 8 wt. %.
B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
B01J 20/06 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The current invention relates to a peritoneal dialysis filter device, which comprises a housing comprising a first port and a second port, and a hollow fibre membrane formed from hollow hydrophilic fibres within the housing. When in use, a dialysate from a subject enters the filter device through the first port and exits via the second port in an outflow direction, and a regenerated dialysate from a sorbent system enters the filter device through the second port and exits via the first port in an inflow direction. Also disclosed herein is a peritoneal dialysis system comprising said filter device, a method for controlling dialysate flow in a peritoneal dialysis system, and a haemodialysis device.
The present disclosure generally relates to a device for analysing spent peritoneal dialysate from a peritoneal dialysis apparatus. The device comprises: a set of housings attachable to the peritoneal dialysis apparatus; a set of test components disposed in the housings, each test component and comprising one or more reagents for detecting one or more substances; and a set of fluidic conduits connected to the housings for communicating the dialysate from the peritoneal dialysis apparatus to the housings, wherein the test components are arranged for the reagents to react with the dialysate communicated to the housings and thereby detect the substances in the dialysate.
Disclosed herein is a material for use in sorbent-based dialysis, the material comprising: acidic and/or neutral cation exchange particles; alkaline anion exchange particles; and one or more of an alkali metal carbonate, a water insoluble alkaline earth metal carbonate, and a water insoluble polymeric ammonium carbonate. Also disclosed herein are uses of said material and its preparation.
B01J 20/04 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of alkali metals, alkaline earth metals or magnesium
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
Disclosed herein is a material for use in sorbent-based dialysis, the material comprising: acidic and/or neutral cation exchange particles; alkaline anion exchange particles; and one or more of an alkali metal carbonate, a water insoluble alkaline earth metal carbonate, and a water insoluble polymeric ammonium carbonate. Also disclosed herein are uses of said material and its preparation.
The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
B01J 39/17 - Organic material containing also inorganic materials, e.g. inert material coated with an ion-exchange resin
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
B01J 47/024 - Column or bed processes characterised by the construction of the column or container where the ion-exchangers are in a removable cartridge
B01D 15/08 - Selective adsorption, e.g. chromatography
B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
The present disclosure generally relates to a device (200) for detecting infection in a patient (102) undergoing peritoneal dialysis. The device (200) comprises: a housing module (202) removably coupleable to a fluidic element (204) configured for receiving waste dialysate fluid (130) from the patient (102); a set of lighting elements (206) disposed on the housing module (202) and configured for emitting light into the fluidic element (204); a set of optical sensors (208) disposed on the housing module (202) and configured for measuring optical properties of the light that has interacted with the waste dialysate fluid (130) in the fluidic element (204); and a control module configured for measuring turbidity of the waste dialysate fluid (130) based on the optical properties, wherein the dialysate turbidity is indicative of infection in the patient (102) if the dialysate turbidity and historical dialysate turbidity of the patient (102) satisfy a set of predefined conditions.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
The present disclosure generally relates to a device (200) for detecting infection in a patient (102) undergoing peritoneal dialysis. The device (200) comprises: a housing module (202) removably coupleable to a fluidic element (204) configured for receiving waste dialysate fluid (130) from the patient (102); a set of lighting elements (206) disposed on the housing module (202) and configured for emitting light into the fluidic element (204); a set of optical sensors (208) disposed on the housing module (202) and configured for measuring optical properties of the light that has interacted with the waste dialysate fluid (130) in the fluidic element (204); and a control module configured for measuring turbidity of the waste dialysate fluid (130) based on the optical properties, wherein the dialysate turbidity is indicative of infection in the patient (102) if the dialysate turbidity and historical dialysate turbidity of the patient (102) satisfy a set of predefined conditions.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
The present disclosure generally relates to a device for analysing spent peritoneal dialysate from a peritoneal dialysis apparatus. The device comprises: a set of housings attachable to the peritoneal dialysis apparatus; a set of test components disposed in the housings, each test component and comprising one or more reagents for detecting one or more substances; and a set of fluidic conduits connected to the housings for communicating the dialysate from the peritoneal dialysis apparatus to the housings, wherein the test components are arranged for the reagents to react with the dialysate communicated to the housings and thereby detect the substances in the dialysate.
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
The current invention relates to a peritoneal dialysis filter device, which comprises a housing comprising a first port and a second port, and a hollow fibre membrane formed from hollow hydrophilic fibres within the housing. When in use, a dialysate from a subject enters the filter device through the first port and exits via the second port in an outflow direction, and a regenerated dialysate from a sorbent system enters the filter device through the second port and exits via the first port in an inflow direction. Also disclosed herein is a peritoneal dialysis system comprising said filter device, a method for controlling dialysate flow in a peritoneal dialysis system, and a haemodialysis device.
The current invention relates to a peritoneal dialysis filter device, which comprises a housing comprising a first port and a second port, and a hollow fibre membrane formed from hollow hydrophilic fibres within the housing. When in use, a dialysate from a subject enters the filter device through the first port and exits via the second port in an outflow direction, and a regenerated dialysate from a sorbent system enters the filter device through the second port and exits via the first port in an inflow direction. Also disclosed herein is a peritoneal dialysis system comprising said filter device, a method for controlling dialysate flow in a peritoneal dialysis system, and a haemodialysis device.
The present disclosure generally relates to a device for analysing spent peritoneal dialysate from a peritoneal dialysis apparatus. The device comprises: a set of housings attachable to the peritoneal dialysis apparatus; a set of test components disposed in the housings, each test component and comprising one or more reagents for detecting one or more substances; and a set of fluidic conduits connected to the housings for communicating the dialysate from the peritoneal dialysis apparatus to the housings, wherein the test components are arranged for the reagents to react with the dialysate communicated to the housings and thereby detect the substances in the dialysate.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
B01J 39/17 - Organic material containing also inorganic materials, e.g. inert material coated with an ion-exchange resin
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
B01D 15/08 - Selective adsorption, e.g. chromatography
B01J 47/024 - Column or bed processes characterised by the construction of the column or container where the ion-exchangers are in a removable cartridge
The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
B01J 47/024 - Column or bed processes characterised by the construction of the column or container where the ion-exchangers are in a removable cartridge
The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.
B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
B01J 47/024 - Column or bed processes characterised by the construction of the column or container where the ion-exchangers are in a removable cartridge
23.
SENSING SYSTEM FOR DETECTING A SUBSTANCE IN A DIALYSATE
A sensing system for detecting a substance in a dialysate. The system includes a hydrophobic barrier capable of allowing the substance in the dialysate to equilibrate through the barrier to a gas. The system also includes a detector capable of detecting the gas and an interface disposed between the hydrophobic barrier and the detector and configured to allow transport of the gas between the hydrophobic barrier and the detector following a concentration gradient of the gas along the interface.
A sensing system for detecting a substance in a dialysate. The system includes a hydrophobic barrier capable of allowing the substance in the dialysate to equilibrate through the barrier to a gas. The system also includes a detector capable of detecting the gas and an interface disposed between the hydrophobic barrier and the detector and configured to allow transport of the gas between the hydrophobic barrier and the detector following a concentration gradient of the gas along the interface.
patents
