The present invention relates to a lightening composition comprising a lightening effective amount of a compound of formula (I), or a tautomer, a stereoisomer, a hydrate, a solvate, a salt, or a polymorph thereof, wherein R1, R2, R3, R4, R5, R6, R7, m and n are as defined in the description and claims. The present invention also relates to a compound of formula (I2) or a tautomer, a stereoisomer, a hydrate, a solvate, a salt, or a polymorph thereof, wherein R1, R2, R3, R4, R5, R6, and R7 are as defined in the description and claims. The present invention also relates to the use of at least one compound of formula (I) or any subgroup thereof, or mixtures thereof, as depigmenting agent. The present invention also relates to the use of at least one compound of formula (I) or any subgroup thereof, or the use of the lightening composition, for preventing and/or reducing pigmentation of normal skin. The present invention also relates to the use of at least one compound, or the use of the lightening composition according to the first aspect, for decreasing the amount of melanin in melanocytes, for decreasing melanin synthesis, for impairing melanin transport and/or for impairing the distribution of melanin in suprabasal layers.
Identification of OR5A2 as an Olfactory Receptor that binds natural musk and synthetic musks and using the interaction of OR5A2 polypeptides and nitromusk, polycyclic musk, macrocyclic musk and alicyclic musks as a basis of screening assays for agents that specifically modulate the activity of the Olfactory Receptor.
A self-tanning composition, such as a sunless tanning composition, a moisturizing composition, or a haircare composition, includes a self-tanning substance. The composition can result in increasing the amount of melanin in melanocytes, increasing melanin synthesis, improving melanin transport, and/or improving the distribution of melanin in suprabasal layers. The composition can be used in methods for darkening skin and/or for sunless tanning.
The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.
The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.
C07C 69/003 - Esters of saturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
C07C 233/09 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
C07C 255/50 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
A malodor counteracting composition has nefopam, or a polymorph, a hydrate or a solvate thereof. The malodor counteracting composition is useful as an attenuator or suppressor for attenuating or suppressing malodors, such as earthy malodor, musty malodor, and/or moldy malodor caused by malodor causing agents, such as geosmin and 2-methylisoborneol.
The invention relates to the use of a compound of formula (IIb), (IIa), (IIIa), (IV), (Ie), (If), (Ig), (Ic), or (Id), a racemate, a stereoisomer, a tautomer, a salt, and/or a solvate thereof, including mixtures thereof, as self-tanning substance, wherein the dash bond .....represents an optional double bond; and wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R20, R21, R22, R23, R24, R25, R27, R28, R29, R40, R42, R43, R44, R45, R46, R47, R50, R51are as defined in the claims. The invention also relates to a compound of formula (Ih), or a racemate, a stereoisomer, a tautomer, a salt, and/or a solvate thereof, including mixtures thereof; (Ih) wherein R5 is as defined in the claims. The invention also relates to self-tanning composition prepared using a compound as defined in the claims, as self-tanning substance. The invention also relates to the use of a compound or a composition as defined herein, for increasing the amount of melanin in melanocytes, for increasing melanin synthesis, for improving melanin transport and/or for improving the distribution of melanin in suprabasal layers, and/or for darkening skin and/or for sunless tanning.
The invention relates to the identification of OR5A2 as an Olfactory Receptor that binds natural musk and synthetic musks. The invention encompasses the use of the interaction of OR5A2 polypeptides and nitromusk, polycyclic musk, macrocyclic musk and alicyclic musks as the basis of screening assays for agents that specifically modulate the activity of the OR of the invention.
The present invention relates to a malodor counteracting composition. In particular the invention relates to a malodor counteracting composition comprising nefopam, or a polymorph, a hydrate or a solvate thereof. The invention also relates to the use of said composition and attenuator or suppressor, for attenuating or suppressing malodors, in particular earthy, musty and/or moldy malodors.
7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.
C07C 69/003 - Esters of saturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
C07C 233/09 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
C07C 255/50 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
The invention relates to the identification of OR5A2 as an Olfactory Receptor that binds natural musk and synthetic musks. The invention encompasses the use of the interaction of OR5A2 polypeptides and nitromusk, polycyclic musk, macrocyclic musk and alicyclic musks as the basis of screening assays for agents that specifically modulate the activity of the OR of the invention.
The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3,R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.
C07C 33/30 - Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings monocyclic
C07C 255/57 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
C07C 233/11 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
C07C 255/34 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
C07C 69/618 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
C07C 69/65 - Halogen-containing esters of unsaturated acids
C07C 43/166 - Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings
C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
C07C 47/232 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde having unsaturation outside the aromatic rings
C07C 47/277 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
C07C 49/217 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings
C07C 57/42 - Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
C07C 59/64 - Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
C07C 33/48 - Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
C07C 43/176 - Unsaturated ethers containing halogen containing six-membered aromatic rings having unsaturation outside the aromatic rings
12.
OLFACTORY RECEPTORS INVOLVED IN THE PERCEPTION OF SWEAT CARBOXYLIC ACIDS AND THE USE THEREOF
The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.
The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.
G01N 33/567 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent utilising isolate of tissue or organ as binding agent
14.
Method for counteracting the perception of sweat malodour by decreasing the function of carboxylic acid-binding olfactory receptors
The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.
G01N 33/567 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent utilising isolate of tissue or organ as binding agent
G01N 33/566 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent
The present invention relates to the use of compositions comprising a melon fruit extract, for attracting Drosophila, more particularly Drosophila suzukii. The invention further relates to traps comprising said compositions and methods for monitoring or trapping Drosophila suzukii.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) (France)
Inventor
Patiny, Sébastien
Jacquin-Joly, Emmanuelle
Montagne, Nicolas
Abstract
The invention relates to the identification of Z9,E12-14:Ac as a natural ligand of the new olfactory/pheromonal receptor SlitOR6, a G-protein coupled-like receptor (GPCR-like). The invention encompasses the use of the interaction of SlitOR6 polypeptides and Z9,E12-14:Ac as the basis of screening assays for agents that modulate the activity of the SlitOR6 receptor. The invention also encompasses diagnostic and other assays performed based upon the SlitOR6/Z9,E12-14:Ac interaction, as well as kits for performing diagnostic and screening assays.
The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3,R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.
C07C 33/30 - Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings monocyclic
C07C 33/48 - Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
C07C 43/166 - Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings
C07C 43/176 - Unsaturated ethers containing halogen containing six-membered aromatic rings having unsaturation outside the aromatic rings
C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
C07C 47/232 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde having unsaturation outside the aromatic rings
C07C 47/277 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
C07C 49/217 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings
C07C 57/42 - Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
C07C 59/64 - Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
C07C 69/618 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
C07C 69/65 - Halogen-containing esters of unsaturated acids
C07C 233/11 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
C07C 255/34 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
C07C 255/57 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
18.
OLFACTORY RECEPTOR INVOLVED IN THE PERCEPTION OF MUSK FRAGRANCE AND THE USE THEREOF
The invention relates to the identification of OR5A2 as an Olfactory Receptor that binds natural musk and synthetic musks. The invention encompasses the use of the interaction of OR5A2 polypeptides and nitromusk, polycyclic musk, macrocyclic musk and alicyclic musks as the basis of screening assays for agents that specifically modulate the activity of the OR of the invention.
The present invention relates to a malodor counteracting composition. In particular the invention relates to a malodor counteracting composition comprising nefopam, or a polymorph, a hydrate or a solvate thereof. The invention also relates to the use of said composition and attenuator or suppressor, for attenuating or suppressing malodors, in particular earthy, musty and/or moldy malodors.
The invention relates to the use of a compound of formula (IIb), (IIa), (IIIa), (IV), (Ie), (If), (Ig), (Ic), or (Id), a racemate, a stereoisomer, a tautomer, a salt, and/or a solvate thereof, including mixtures thereof, as self-tanning substance, wherein the dash bond ..... represents an optional double bond; and wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R20, R21, R22, R23, R24, R25, R27, R28, R29, R40, R42, R43, R44, R45, R46, R47, R50, R51 are as defined in the claims. The invention also relates to a compound of formula (Ih), or a racemate, a stereoisomer, a tautomer, a salt, and/or a solvate thereof, including mixtures thereof; (Ih) wherein R5 is as defined in the claims. The invention also relates to self-tanning composition prepared using a compound as defined in the claims, as self-tanning substance. The invention also relates to the use of a compound or a composition as defined herein, for increasing the amount of melanin in melanocytes, for increasing melanin synthesis, for improving melanin transport and/or for improving the distribution of melanin in suprabasal layers, and/or for darkening skin and/or for sunless tanning.
patents
