Systems and methods of detecting and monitoring edema in a subject are described. The systems and methods include light sources, image detectors, filters, and processors that determine whether a subject has edema and the degree of severity. In some embodiments, the processor fuses data from more than one imaging modality.
A liquid crystal tunable filter (LCTF) assembly capable of switching between a multi-conjugate filter (MCF) mode and a conformal filter (CF) mode is described. The switching is achieved by placing one or more of the LCTF stages in, or removing one or more of the LCTF stages from, the optical path. The assembly can include a first LCTF component including a first optical filter having a first optical axis, a second optical filter having a second optical axis, wherein the second optical axis is rotated 90° relative to the first optical axis, and a second LCTF component including a third optical filter having a third optical axis, and a fourth optical filter having a fourth optical axis, wherein the fourth optical axis is rotated 90° relative to the third optical axis.
Systems and methods for detecting and monitoring wounds and pathogens in wounds via molecular chemical imaging are described herein. The systems may include an image sensor configured to collect image data from interacted photons from a wound that is illuminated with a plurality of wavelengths of light, a processor configured to analyze the image data and identify one or more of a pathogen amount, a pathogen identity, a perfusion state, or a fluid state of a wound based on the image data.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
A method for improved disease monitoring is disclosed. The method includes receiving image data from an image sensor configured for monitoring a hypothesis disease in a patient. Additional data is received from one or more additional sensors configured to monitor one or more factors related to disease activity of the patient. The received image data is fused with the received additional data from the one or more additional sensors to generate fused data set. A disease condition for the patient is determined based on the fused data set. A disease monitoring computing device and non-transitory medium are also disclosed.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G06V 10/60 - Extraction of image or video features relating to illumination properties, e.g. using a reflectance or lighting model
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
A method for improved disease monitoring is disclosed. The method includes receiving image data from an image sensor configured for monitoring a hypothesis disease in a patient. Additional data is received from one or more additional sensors configured to monitor one or more factors related to disease activity of the patient. The received image data is fused with the received additional data from the one or more additional sensors to generate fused data set. A disease condition for the patient is determined based on the fused data set. A disease monitoring computing device and non-transitory medium are also disclosed.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
6.
in situ optimization of tunable light emitting diode sources
Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.
A non-mechanical liquid crystal tunable filter (LCTF) assembly capable of switching between a multi-conjugate filter mode and a conformal filter mode is described. The non-mechanical LCTF architecture can include a plurality of LCTF components that each comprises a first optical filter comprising a first optical axis, a second optical filter comprising a second optical axis, wherein the second optical axis is rotated 90° relative to the first optical axis, and a first twisted nematic cell positioned between the first optical filter and the second optical filter, the first twisted nematic cell configured to polarize received light by 90° when a voltage is not applied and not polarize the received light when the voltage is applied. The non-mechanical LCTF assembly is configured to switch between a conformal filter mode and a multi-conjugate filter mode based on whether the voltage is applied to each of the plurality of LCTF components.
G02F 1/1347 - Arrangement of liquid crystal layers or cells in which the final condition of one light beam is achieved by the addition of the effects of two or more layers or cells
A non-mechanical liquid crystal tunable filter (LCTF) assembly capable of switching between a multi-conjugate filter mode and a conformal filter mode is described. The non-mechanical LCTF architecture can include a plurality of LCTF components that each comprises a first optical filter comprising a first optical axis, a second optical filter comprising a second optical axis, wherein the second optical axis is rotated 90° relative to the first optical axis, and a first twisted nematic cell positioned between the first optical filter and the second optical filter, the first twisted nematic cell configured to polarize received light by 90° when a voltage is not applied and not polarize the received light when the voltage is applied. The non-mechanical LCTF assembly is configured to switch between a conformal filter mode and a multi-conjugate filter mode based on whether the voltage is applied to each of the plurality of LCTF components.
In order to avoid friendly fire incidents in the combat theater, novel covert identification systems and methods of identifying friendly forces are provided. The systems include at least a spectroscopic imaging device and a marker that interact with each other by using a synchronized, predetermined filter tuning sequence. The filter tuning sequence enables interacted photons to wavelength hop according to the predetermined tuning sequence. As a result, the covert identification system allows friendly forces to clearly identify each while avoiding detection by enemy forces that employ conventional broadband and night vision sensors.
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
10.
Discrimination of calculi and tissues with molecular chemical imaging
Systems and methods for the detection of calculi in the biliary system are disclosed. The systems include an illumination source, one or more filters that filter a first set of illumination photons and a second set of illumination photons, as well as associated processors and detectors. The system is also designed to generate image data sets and generated information related to the location of the calculi.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
11.
Systems and methods of conformal spectral library training
The conformal spectral library training method (CSLTM) of the disclosure allows sets of voltages for an optical filter to be calculated by way of a direct calculation without processing large amounts of spectral information, which significantly increases the speed of processing spectral information.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
12.
Systems and methods for spectral processing improvements in spatial heterodyne spectroscopy
Raman spectroscopy data is collected using a Spatial Heterodyne Spectrometer and processed in order to reduce signal noise. The processing of the Raman spectroscopy data includes segmenting generating an interferogram from the Raman spectroscopy data, segmenting the interferogram, determining an estimate of power spectrum density, and averaging the estimates of power spectrum density for each segment to provide an output spectrum. The output spectrum has greatly reduced variance of the individual power measurements, and allows the length of segments to be optimized to balance noise reduction operations and the loss of frequency resolution.
Raman spectroscopy data is collected using a Spatial Heterodyne Spectrometer and processed in order to reduce signal noise. The processing of the Raman spectroscopy data includes segmenting generating an interferogram from the Raman spectroscopy data, segmenting the interferogram, determining an estimate of power spectrum density, and averaging the estimates of power spectrum density for each segment to provide an output spectrum. The output spectrum has greatly reduced variance of the individual power measurements, and allows the length of segments to be optimized to balance noise reduction operations and the loss of frequency resolution.
The conformal spectral library training method (CSLTM) of the disclosure allows sets of voltages for an optical filter to be calculated by way of a direct calculation. Methods, optical devices, and software are disclosed.
G01J 3/30 - Measuring the intensity of spectral lines directly on the spectrum itself
G01J 3/36 - Investigating two or more bands of a spectrum by separate detectors
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
Methods for improved tissue perfusion monitoring are disclosed. A method includes collecting hyperspectral image data from an image sensor positioned to collect interacted photons from a tissue region resulting from illumination of the tissue sample at a plurality of wavelengths in the visible, near infrared, or shortwave infrared regions. Hypercubes are generated based on the collected hyperspectral image data. The hypercubes are analyzed to identify one or more of the plurality of wavelengths resulting in contrast in the hyperspectral images. One or more regions in the tissue region with altered perfusion states are identified based on the contrast in the hyperspectral images. A tissue perfusion monitoring computing device and non-transitory medium are also disclosed.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G01N 33/483 - Physical analysis of biological material
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
16.
A METHOD FOR FUSING SENSOR DATA FOR CARDIAC MONITORING AND DEVICES THEREOF
A method for improved cardiac monitoring is disclosed. The method includes receiving image data from an image sensor configured for monitoring edema in a patient. Additional data is received from one or more additional sensors configured to monitor one or more factors related to cardiac activity of the patient. The received image data is fused with the received additional data from the one or more additional sensors to generate fused data set. A cardiac condition for the patient is determined based on the fused data set. A cardiac monitoring computing device and non-transitory medium are also disclosed.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
17.
Method for fusing sensor data for cardiac monitoring and devices thereof
A method for improved cardiac monitoring is disclosed. The method includes receiving image data from an image sensor configured for monitoring edema in a patient. Additional data is received from one or more additional sensors configured to monitor one or more factors related to cardiac activity of the patient. The received image data is fused with the received additional data from the one or more additional sensors to generate fused data set. A cardiac condition for the patient is determined based on the fused data set. A cardiac monitoring computing device and non-transitory medium are also disclosed.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
G06V 10/80 - Fusion, i.e. combining data from various sources at the sensor level, preprocessing level, feature extraction level or classification level
G06V 20/52 - Surveillance or monitoring of activities, e.g. for recognising suspicious objects
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
18.
DUAL-MODE MULTI-CONJUGATE FILTER BASED ON DIFFERENT VOLTAGE DRIVEN SCHEMES
A multi-conjugate filter (MCF) can be operated in both a single bandpass mode and a multiple bandpass mode. By applying different voltages to different channels of a MCF, the MCF can be used to filter light into (1) a single narrow spectral output or (2) a broad ranged "white light" spectral output.
G02F 1/13 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells
G02F 1/133 - Constructional arrangementsOperation of liquid crystal cellsCircuit arrangements
G02F 1/1337 - Surface-induced orientation of the liquid crystal molecules, e.g. by alignment layers
G02F 1/1347 - Arrangement of liquid crystal layers or cells in which the final condition of one light beam is achieved by the addition of the effects of two or more layers or cells
G02F 1/139 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells characterised by the electro-optical or magneto-optical effect, e.g. field-induced phase transition, orientation effect, guest-host interaction or dynamic scattering based on orientation effects in which the liquid crystal remains transparent
19.
SYSTEMS AND METHODS FOR DETECTING ORAL CANCER USING MOLECULAR CHEMICAL IMAGING
Methods and systems of identifying oral cancer in vivo are disclosed. An oral cavity of a patient is illuminated with a plurality of illuminating photons. A plurality of interacted photos are received from the oral cavity. The interacted photons may have been absorbed, reflected, scattered or emitted by the oral cavity. The interacted photons are filtered into first and second polarized multi-passband wavelengths using first and second tunable conformal filters, respectively. A detector captures the first and second polarized multi-passband wavelengths. A processor automatically discriminates between cancerous tissue and non-cancerous tissue in an image resolved from the first and second polarized multi-passband wavelengths.
Systems and methods designed to determine tumor histological subtypes in order to guide a surgical procedure. The systems and methods illuminate biological tissue in order to generate a plurality of interacted photons, collect the interacted photons, detect the plurality of a interacted photons to generate at least one hyperspectral image, and analyze a hyperspectral image by extracting a spectrum from a location in the hyperspectral image. The location should correspond to an area that is of interest in the biological tissue.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 21/33 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
G01N 33/483 - Physical analysis of biological material
21.
SYSTEMS AND METHODS FOR SIMULTANEOUS WOUND DETECTION AND THERAPY
Medical conditions in tissues are simultaneously imaged and treated using light within selected wavelength ranges. By treating conditions, such as wounds, lesions, and tumors, at the same time that they are imaged, the overall diagnostic and treatment time is substantially reduced.
Systems and methods designed to determine tumor histological subtypes in order to guide a surgical procedure. The systems and methods illuminate biological tissue in order to generate a plurality of interacted photons, collect the interacted photons, detect the plurality of a interacted photons to generate at least one hyperspectral image, and analyze a hyperspectral image by extracting a spectrum from a location in the hyperspectral image. The location should correspond to an area that is of interest in the biological tissue.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
23.
CONCEALED SUBSTANCE DETECTION WITH HYPERSPECTRAL IMAGING
A drug screening system and methods of using the same are disclosed. The drug screening system identifies and highlights drugs or other contraband substances enclosed within mailpieces based on score imagery computed from selected wavelengths based on chemical signatures. A wide-field, multispectral short-wave infrared imaging system allows for dissolved, concealed drug screening of mailpieces that improve inspection efficiency and accuracy.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G06K 9/46 - Extraction of features or characteristics of the image
24.
Concealed substance detection with hyperspectral imaging
A drug screening system and methods of using the same are disclosed. The drug screening system identifies and highlights drugs or other contraband substances enclosed within mailpieces based on score imagery computed from selected wavelengths based on chemical signatures. A wide-field, multispectral short-wave infrared imaging system allows for dissolved, concealed drug screening of mailpieces that improve inspection efficiency and accuracy.
Techniques, devices and methods for discriminating a target from a background material without optimizing directly on the target are provided. The devices and methods can generate pass bands of single or multiple wavelengths of variable shape and intensity, and can also select and control the shape of the pass band profiles to improve the detection of targets of interest.
Techniques, devices and methods for discriminating a target from a background material without optimizing directly on the target are provided. The devices and methods can generate pass bands of single or multiple wavelengths of variable shape and intensity, and can also select and control the shape of the pass band profiles to improve the detection of targets of interest.
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
27.
SYSTEMS AND METHODS OF COMBINING IMAGING MODALITIES FOR IMPROVED TISSUE DETECTION
Systems of methods of combining imaging modalities for improved target detection within a sample are disclosed herein. The system can be configured to receive two or more images captured using different imaging modalities, create a score image from one of the captured images, fuse the second image and the score image together, identify the target within the score image or the fused image, register the received images together, and overlay the detected target on the first image. The first image can include an image captured using molecular chemical imaging and the second image can include a RGB image, for example.
Systems of methods of combining imaging modalities for improved target detection within a sample are disclosed herein. The system can be configured to receive two or more images captured using different imaging modalities, create a score image from one of the captured images, fuse the second image and the score image together, identify the target within the score image or the fused image, register the received images together, and overlay the detected target on the first image. The first image can include an image captured using molecular chemical imaging and the second image can include a RGB image, for example.
A method for multi-target detection and an apparatus for multi-target detection are capable of detecting at least two targets in real time or near real time. The real-time detection or near real time detection can be achieved by at least one of a Recipe Group Approach, an End Member Grouping Approach, and a Pixelated Grouping Based Approach.
G06V 30/198 - Recognition using electronic means using sequential comparisons of the image signals with a plurality of references the selection of the next reference depending on the result of the preceding comparison
G06V 30/194 - References adjustable by an adaptive method, e.g. learning
G06K 9/62 - Methods or arrangements for recognition using electronic means
G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
30.
SYSTEMS AND METHODS FOR DISCRIMINATION OF TISSUE TARGETS
Systems for and methods for detecting samples and other compounds of interest are disclosed herein. The system can include an illumination source that is configured to emit light in a variety of different wavelength bands, an optical filter, a camera chip, and an optical path configured to direct the light emitted by the first illumination source at a target and direct the light reflected from the target to the at least one camera chip. The illumination source and the optical filter are transitionable between a first tuning state corresponding to a target tissue and a second tuning state corresponding to a background tissue. The system can be configured to record images at the different tuning states and generate a score image corresponding to the target tissue based on the recorded images.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
31.
Systems and methods for discrimination of tissue targets
Systems for and methods for detecting samples and other compounds of interest are disclosed herein. The system can include an illumination source that is configured to emit light in a variety of different wavelength bands, an optical filter, a camera chip, and an optical path configured to direct the light emitted by the first illumination source at a target and direct the light reflected from the target to the at least one camera chip. The illumination source and the optical filter are transitionable between a first tuning state corresponding to a target tissue and a second tuning state corresponding to a background tissue. The system can be configured to record images at the different tuning states and generate a score image corresponding to the target tissue based on the recorded images.
G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
32.
METHODS FOR IMPROVED OPERATIVE SURGICAL REPORT GENERATION USING MACHINE LEARNING AND DEVICES THEREOF
Methods, non-transitory computer readable media, and surgical video analysis devices are disclosed that provide an improved, automated surgical report generation. With this technology, a video associated with a surgical procedure comprising a plurality of frames is obtained. The plurality of frames of the obtained video are compared to a historical set of surgical procedure images, wherein the historical set of surgical procedure images are associated with contextual information. One or more objects of interest are identified in at least a subset of the plurality of frames based on the comparison and the associated contextual information. The identified one or more objects of interest are tracked across the at least the subset of the plurality of frames. A surgical report based on tracked one or more objects.
G06T 19/00 - Manipulating 3D models or images for computer graphics
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
A method for multi-target detection and an apparatus for multi-target detection are capable of detecting at least two targets in real time or near real time. The real-time detection or near real time detection can be achieved by at least one of a Recipe Group Approach, an End Member Grouping Approach, and a Pixelated Grouping Based Approach.
G01N 33/94 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving narcotics
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
34.
IN SITU OPTIMIZATION OF TUNABLE LIGHT EMITTING DIODE SOURCES
Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.
Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.
Methods, systems, and computer program products of fusing Molecular Chemical Imaging (MCI) and Red Green Blue (RGB) images are disclosed herein. A sample is illuminated with illuminating photons which interact with the sample and are used to form MCI and RGB images. The MCI and RGB images are fused by way of mathematical operations to generate a RGB image with a detection overlay.
Methods, systems, and computer program products of fusing Molecular Chemical Imaging (MCI) and Red Green Blue (RGB) images are disclosed herein. A sample is illuminated with illuminating photons which interact with the sample and are used to form MCI and RGB images. The MCI and RGB images are fused by way of mathematical operations to generate a RGB image with a detection overlay.
The instant disclosure provides for medical imaging systems that may be used in conjunction with an intraoperative medical device, such as an endoscope. Generally, the disclosed medical imaging systems include an illumination source configured to generate illuminating photons for illuminating a biological sample. An optical signal modulator is configured to separate one or more of the illuminating photons and photons that have interacted with the biological sample into a first optical signal having first multi-passband wavelengths and a second optical signal having second multi-passband wavelengths. At least one detector is configured to detect one or more of the first optical signal and the second optical signal and generate at least one image data set. A processor is configured to analyze the at least one image data set. In some embodiments, the processor is configured to differentiate between structures of the biological sample, such as between an ureter and surrounding tissue.
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 1/307 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
The disclosure provides methods, systems, and computer program products for detecting compounds of interest that are deposited on or associated with objects of interest. The compounds of interest are not limited and include drugs, alcohol, cannabis, narcotics, controlled substances as defined by state, federal, or international law, ammonium-based explosives, MGE-based explosives, toxic compounds, organic compounds, inorganic compounds, nerve agents, or biological compounds. The disclosure increases the speed and efficiency of processing hyperspectral images, especially on low-power or portable devices.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G06N 3/12 - Computing arrangements based on biological models using genetic models
40.
HYBRID IMAGING PRODUCT AND HYBRID ENDOSCOPIC SYSTEM
An endoscope has an improved chip-on-tip configuration that includes both a first configuration of source illumination fibers and a second plurality of source illumination fibers, along with a camera chip. The combination of the camera chip and the source illumination fibers on the tip of the endoscope results in endoscopes with reduced size and weight.
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
41.
HYBRID IMAGING PRODUCT AND HYBRID ENDOSCOPIC SYSTEM
An endoscope has an improved chip-on-tip configuration that includes both a first configuration of source illumination fibers and a second plurality of source illumination fibers, along with a camera chip. The combination of the camera chip and the source illumination fibers on the tip of the endoscope results in endoscopes with reduced size and weight.
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
The disclosure provides methods, systems, and computer program products for detecting compounds of interest that are deposited on or associated with objects of interest. The compounds of interest are not limited and include drugs, alcohol, cannabis, narcotics, controlled substances as defined by state, federal, or international law, ammonium-based explosives, MGE-based explosives, toxic compounds, organic compounds, inorganic compounds, nerve agents, or biological compounds. The disclosure increases the speed and efficiency of processing hyperspectral images, especially on low-power or portable devices.
G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
B07C 5/00 - Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or featureSorting by manually actuated devices, e.g. switches
Systems and methods of detecting and monitoring edema in a subject are described. The systems and methods include light sources, image detectors, filters, and processors that determine whether a subject has edema and the degree of severity. In some embodiments, the processor fuses data from more than one imaging modality.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
G02F 1/1335 - Structural association of cells with optical devices, e.g. polarisers or reflectors
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
Systems and methods of detecting and monitoring edema in a subject are described. The systems and methods include light sources, image detectors, filters, and processors that determine whether a subject has edema and the degree of severity. In some embodiments, the processor fuses data from more than one imaging modality.
In order to avoid friendly fire incidents in the combat theater, novel covert identification systems and methods of identifying friendly forces are provided. The systems include at least a spectroscopic imaging device and a marker that interact with each other by using a synchronized, predetermined filter tuning sequence. The filter tuning sequence enables interacted photons to wavelength hop according to the predetermined tuning sequence. As a result, the covert identification system allows friendly forces to clearly identify each while avoiding detection by enemy forces that employ conventional broadband and night vision sensors.
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
G01N 21/62 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
Conformal vision with enhanced image processing of the outputted image is incorporated into novel applications. The conformal vision provides enhanced contrast by the combined inclusion of tunable filters and processing of the images that are generated by the detector. Furthermore, novel uses and applications of the conformal vision enable users to make determinations related to their health and wellness utilizing information provided by the conformal vision.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/16 - Devices for psychotechnicsTesting reaction times
42 - Scientific, technological and industrial services, research and design
Goods & Services
Software as a service (SAAS) services featuring software for labeling datasets for supervised learning applications in the fields of advanced product research and artificial intelligence; scientific research in the technology field of global computer systems and the Internet; none of the foregoing in connection with providing enterprise data management, data storage, data backup, data security, data recovery, workflow management, disaster recovery or business continuity services for others
48.
Discrimination of calculi and tissues with molecular chemical imaging
Systems and methods for the detection of calculi in the biliary system are disclosed. The systems include an illumination source, one or more filters that filter a first set of illumination photons and a second set of illumination photons, as well as associated processors and detectors. The system is also designed to generates image data sets and generated information related to the location of the calculi.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
49.
DISCRIMINATION OF CALCULI AND TISSUES WITH MOLECULAR CHEMICAL IMAGING
Systems and methods for the detection of calculi in the biliary system are disclosed. The systems include an illumination source, one or more filters that filter a first set of illumination photons and a second set of illumination photons, as well as associated processors and detectors. The system is also designed to generates image data sets and generated information related to the location of the calculi.
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Chemical analysis and testing; development, evaluation, testing, and demonstration of new products and equipment, namely, scientific instrumentation; development and testing of chemical analysis techniques and methods; modeling and computer simulations in the field of chemical and biological analysis and testing; chemical analysis and development, namely, elemental and chemical speciation analysis and development; chemical analysis and development, namely, chemical statistical analysis and development; chemical analysis and development, namely, ultra-trace elemental analysis and development; problem solving using chemical analyses and testing; materials testing and evaluation; chemical, biochemical, and biological materials, biological, biomedical, and water analysis; forensics analysis using chemical, biological, biomedical and biochemical methods and techniques; chemical imaging, raman imaging, fluorescence imaging for scientific, industrial, commercial and non-medical purposes Chemical imaging, raman imaging, fluorescence imaging for medical purposes
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded software for use in connection with detection, identification, classification and assessment of known and unknown materials, namely, chemical, biological, explosive, hazardous, illicit drug, and food and beverage contaminants and spoilage in a variety of differing environmental and weather conditions; recorded computer software and recorded software algorithms for use in manipulating received or inputted data for use in database management, imaging and spectroscopy systems, spectroscopes, endoscopes, fiberscopes, microscopes, macroscopes, and probes for use in analyzing chemical bonding and atomic structures of materials, chemical and material analysis and testing, scientific instrumentation development, testing, and demonstration, chemical and material analysis technique and method development, modeling and computer simulations based on chemistry, biology, and physics, and also for use in elemental and chemical speciation analysis and development, chemical statistical analysis and development, ultra-trace elemental and bulk material analysis and development, chemical problem solving and new equipment evaluation and testing
52.
MOLECULAR CHEMICAL IMAGING ENDOSCOPIC IMAGING SYSTEMS
The instant disclosure provides for medical imaging systems that may be used in conjunction with an intraoperative medical device, such as an endoscope. Generally, the disclosed medical imaging systems include an illumination source configured to generate illuminating photons for illuminating a biological sample. An optical signal modulator is configured to separate one or more of the illuminating photons and photons that have interacted with the biological sample into a first optical signal having first multi-passband wavelengths and a second optical signal having second multi-passband wavelengths. At least one detector is configured to detect one or more of the first optical signal and the second optical signal and generate at least one image data set. A processor is configured to analyze the at least one image data set. In some embodiments, the processor is configured to differentiate between structures of the biological sample, such as between an ureter and surrounding tissue.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
09 - Scientific and electric apparatus and instruments
Goods & Services
Recorded software for use in connection with detection, identification, classification and assessment of known and unknown materials, namely, chemical, biological, explosive, hazardous, illicit drug, and food and beverage contaminants and spoilage in a variety of differing environmental and weather conditions; recorded computer software and recorded software algorithms for use in manipulating received or inputted data for use in database management, imaging and spectroscopy systems, spectroscopes, endoscopes, fiberscopes, microscopes, macroscopes, and probes for use in analyzing chemical bonding and atomic structures of materials, chemical and material analysis and testing, scientific instrumentation development, testing, and demonstration, chemical and material analysis technique and method development, modeling and computer simulations based on chemistry, biology, and physics, and also for use in elemental and chemical speciation analysis and development, chemical statistical analysis and development, ultra-trace elemental and bulk material analysis and development, chemical problem solving and new equipment evaluation and testing
42 - Scientific, technological and industrial services, research and design
Goods & Services
Software as a service (SAAS) services featuring software for labeling datasets for supervised learning applications in the fields of advanced product research and artificial intelligence; scientific research in the technology field of global computer systems and the Internet
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical apparatus and instruments for monitoring edema in tissue of patients Medical diagnostic testing, monitoring and reporting services; trans-telephonic heart monitoring services
56.
Systems and methods for detecting edema by fusing hyperspectral and visible image
System and method for detecting and monitoring edema in a patient are described. Initially, a patient's tissue is irradiated with light by a light source. A detector collects reflected light from the patient's tissue and generates data associated with the reflected light. A processing device receives the data and reflected light and calculates an intensity of the reflected light. The processing device then determined, based upon the intensity of the reflected light, whether the patient's tissue exhibits any symptoms of edema. Additionally, the processing device can compare a current intensity of the reflected light against historic information to monitor for any changes in a patient's edema level or severity.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
G02F 1/1335 - Structural association of cells with optical devices, e.g. polarisers or reflectors
G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
An endoscope has an improved chip-on-tip configuration that includes both a first configuration of source illumination fibers and a second plurality of source illumination fibers, along with a camera chip. The combination of the camera chip and the source illumination fibers on the tip of the endoscope results in endoscopes with reduced size and weight.
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
An endoscope has an improved chip-on-tip configuration that includes both a first configuration of source illumination fibers and a second plurality of source illumination fibers, along with a camera chip. The combination of the camera chip and the source illumination fibers on the tip of the endoscope results in endoscopes with reduced size and weight.
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
H04N 23/11 - Cameras or camera modules comprising electronic image sensorsControl thereof for generating image signals from different wavelengths for generating image signals from visible and infrared light wavelengths
H04N 23/45 - Cameras or camera modules comprising electronic image sensorsControl thereof for generating image signals from two or more image sensors being of different type or operating in different modes, e.g. with a CMOS sensor for moving images in combination with a charge-coupled device [CCD] for still images
H04N 23/55 - Optical parts specially adapted for electronic image sensorsMounting thereof
H04N 23/56 - Cameras or camera modules comprising electronic image sensorsControl thereof provided with illuminating means
Conformal vision with enhanced image processing of the outputted image is incorporated into novel applications. The conformal vision provides enhanced contrast by the combined inclusion of tunable filters and processing of the images that are generated by the detector. Furthermore, novel uses and applications of the conformal vision enable users to make determinations related to their health and wellness utilizing information provided by the conformal vision.
G01J 3/32 - Investigating bands of a spectrum in sequence by a single detector
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G02F 1/1347 - Arrangement of liquid crystal layers or cells in which the final condition of one light beam is achieved by the addition of the effects of two or more layers or cells
This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The instant disclosure provides for medical imaging systems that may be used in conjunction with an intraoperative medical device, such as an endoscope. Generally, the disclosed medical imaging systems include an illumination source configured to generate illuminating photons for illuminating a biological sample. An optical signal modulator is configured to separate one or more of the illuminating photons and photons that have interacted with the biological sample into a first optical signal having first multi-passband wavelengths and a second optical signal having second multi-passband wavelengths. At least one detector is configured to detect one or more of the first optical signal and the second optical signal and generate at least one image data set. A processor is configured to analyze the at least one image data set. In some embodiments, the processor is configured to differentiate between structures of the biological sample, such as between an ureter and surrounding tissue.
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 1/307 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
62.
Molecular chemical imaging endoscopic imaging systems
Medical imaging systems for use in conjunction with an endoscope are described. Generally, the medical imaging system includes an illumination source configured to generate illuminating photons. The illuminating photons are transmitted to one or more filters configured to filter a first plurality of illuminating photons and generate a first plurality of filtered photons comprising a first passband wavelength and a second plurality of filtered photons comprising a second passband wavelength. A sample is then illuminated with the first plurality of filtered photons and the second plurality of filtered photons to generate a first plurality of interacted photons and a second plurality of interacted photons. One or more detectors are configured to detect the first plurality of interacted photons and the second plurality of interacted photons and generate one or more image data sets.
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
System and method for detecting and monitoring edema in a patient are described. Initially, a patient's tissue is irradiated with light by a light source. A detector collects reflected light from the patient's tissue and generates data associated with the reflected light. A processing device receives the data and reflected light and calculates an intensity of the reflected light. The processing device then determined, based upon the intensity of the reflected light, whether the patient's tissue exhibits any symptoms of edema. Additionally, the processing device can compare a current intensity of the reflected light against historic information to monitor for any changes in a patient's edema level or severity.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific apparatus and instruments, namely, portable, handheld, person-borne, vehicle mounted, stationary, on-the-move, aerial, microscopic, macroscopic, spectroscopes, endoscopes, fiberscopes and standoff detection devices and sensors based on hyperspectral imaging, chemical imaging, and spectroscopy; scientific apparatus and instruments, namely, hyperspectral imaging sensors for detection, identification, classification and assessment of known and unknown materials, namely, chemical, biological, explosive, hazardous, illicit drugs, food and beverage contaminants and spoilage, environmental and weather conditions, medical and predictive maintenance applications; computer hardware, computer software and software algorithms for use in manipulating received or inputted data and for use in database management, imaging and spectroscopy systems, spectroscopes, endoscopes, fiberscopes, microscopes, macroscopes, and probes for use in analyzing chemical bonding and atomic structures of materials, chemical and material analysis and testing, scientific instrumentation development, testing, and demonstration, chemical and material analysis technique and method development, modeling and computer simulations based on chemistry, biology, and physics; and also for use in elemental and chemical speciation analysis and development; chemical statistical analysis and development; ultra-trace elemental and bulk material analysis and development; chemical problem solving; new equipment evaluation and testing Scientific and technological services, namely, scientific analysis and testing, technological research and design, consulting, namely, scientific analysis and testing, technological research and design, research, computer hardware and software development, algorithm development and design relating to the detection, identification, classification, and assessment of known and unknown materials, namely, chemical, biological, explosive, hazardous, illicit and legal drugs, food and beverage contaminants and spoilage, environmental and weather conditions, and predictive maintenance applications; scientific analysis and testing of the materials or products of third parties and development of new products or refinement of existing products of third parties utilizing chemical imaging, hyperspectral imaging, spectroscopy, and mapping techniques; quality control testing of new products; scientific consulting services in the field of new product testing and development; consulting in the fields of analytical instrument design, development of new applications for analytical instruments, establishing materials testing protocols, new product testing, and the transfer of technology into new products and new product applications
This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.
The present disclosure provides systems and methods for determining the presence of a target material in a sample. In general terms, the system and method disclosed herein provide collecting interacted photons from a sample having a target material. The interacted photons are passed through a tunable filter to a VIS-NIR detector where the VIS-NIR detector generates a VIS-NIR hyperspectral image representative of the filtered interacted photons. The hyperspectral image of the filtered interacted photons is analyzed by comparing the hyperspectral image of the filtered interacted photons to known hyperspectral images to identify the presence of a target material in a sample. The systems and methods disclosed herein provide easy identification of the presence of a target material in a sample.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
The present disclosure provides for a system and method for detecting and identifying unknown targets. At least one region of interest comprising an unknown target in a sample scene may be targeted using SWIR spectroscopic techniques. A region of interest may be surveyed to thereby determine whether or not a human is present. This surveying may be achieved my assessing LWIR data, data acquired from motion sensors, and combinations thereof. If no human is present in a region of interest, the region may be interrogated using Raman spectroscopic techniques to thereby obtain a Raman data set representative of the region of interest. This Raman data set may be assessed to thereby identify said unknown target. This assessment may be achieved by comparing the Raman data set to a reference data sets in a reference database, where each reference data set is associated with a known target.
A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.
A first location comprising an unknown material may be scanned using SWIR hyperspectral imaging in a dual polarization configuration. Surveying may also be applied to thereby determine whether or not a human is present. This surveying may be achieved my assessing LWIR data, data acquired from motion sensors, and combinations thereof. If no human is present, a second location may be interrogated using Raman spectroscopic techniques to thereby obtain a Raman data set representative of the region of interest. This Raman data set may be assessed to associate an unknown material with a known material. This assessment may be achieved by comparing the Raman data set to one or more reference data sets in a reference database, where each reference data set is associated with a known material.
The present disclosure provides for a system and method for analyzing a sample comprising at least one unknown material. A first location may be scanned to generate a SWIR hyperspectral image. The SWIR hyperspectral image may be generated using dual polarization techniques. The SWIR hyperspectral image may be analyzed to target a second location comprising the unknown material. This second location may be further analyzed using Raman spectroscopic techniques and a Raman data set may be generated. The Raman data set may be further analyzed to associate the unknown material with a know material.
A system and method for analyzing unknown materials on surfaces including, but not limited to, chemical materials, biological materials, hazardous materials, drug materials, and non-threat materials using SWIR and/or extended range SWIR hyperspectral and spectroscopic techniques. A system comprising a collection optics, a tunable filter, and a first detector for generating a test data set representative of the unknown sample. A second detector, comprising a visible imaging device, may be configured to operate in a scanning mode to locate areas of interest for further interrogation using SWIR. A method comprising generating a SWIR test data set representative of the unknown sample and analyzing the unknown sample to detect, identify and/or distinguish an unknown material as a known material. This analysis may be achieved by comparing the test data set to a reference data set using at least one chemometric technique.
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
G01J 3/32 - Investigating bands of a spectrum in sequence by a single detector
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
09 - Scientific and electric apparatus and instruments
Goods & Services
Scientific apparatus and instruments, namely, portable, handheld, person-borne, vehicle mounted, stationary, on-the-move, aerial, microscopic, macroscopic, and standoff detection devices and sensors not for medical use based on hyperspectral imaging, chemical imaging, and spectroscopy; scientific apparatus and instruments, namely, hyperspectral imaging sensors for detection, identification, classification and assessment of known and unknown materials, namely, chemical, biological, explosive, hazardous, illicit drugs, food and beverage contaminants and spoilage, environmental and weather conditions, and predictive maintenance applications; computer hardware, computer software and software algorithms for use in manipulating received or inputted data and for use in database management, imaging and spectroscopy systems, spectroscopes, endoscopes, fiberscopes, microscopes, macroscopes, and probes for use in analyzing chemical bonding and atomic structures of materials, chemical and material analysis and testing, scientific instrumentation development, testing, and demonstration, chemical and material analysis technique and method development, modeling and computer simulations based on chemistry, biology, and physics, and also for use in elemental and chemical speciation analysis and development, chemical statistical analysis and development, ultra-trace elemental and bulk material analysis and development, chemical problem solving and new equipment evaluation and testing
74.
SWIR targeted agile raman (STAR) system for on-the-move detection of emplace explosives
The present disclosure provides for a system and method for detecting explosives and other materials in a sample scene. First interacted photons are produced from a target area wherein the first interacted photons are generated via solar radiation. The first interacted photons are assessed to thereby generate a SWIR hyperspectral image. The SWIR hyperspectral image is analyzed to identify an area of interest likely of comprising an explosive material. The area of interest is illuminated using laser light illumination to generate second interacted photons from the area of interest. These second interacted photons are assessed to determine whether it not an explosive material is present in the area of interest. The system and method may be configured in standoff, OTM, static and UGV configurations.
A system and method for locating and identifying unknown samples. A targeting mode may be utilized to scan regions of interest for potential unknown materials. This targeting mode may interrogate regions of interest using SWIR and/or fluorescence spectroscopic and imaging techniques. Unknown samples detected in regions of interest may be further interrogated using a combination of Raman and LIBS techniques to identify the unknown samples. Structured illumination may be used to interrogate an unknown sample. Data sets generated during interrogation may be compared to a reference database comprising a plurality of reference data sets, each associated with a known material. The system and method may be used to identify a variety of materials including: biological, chemical, explosive, hazardous, concealment, and non-hazardous materials.
A system and method for locating and identifying unknown samples. A targeting mode may be utilized to scan regions of interest for potential unknown materials. This targeting mode may interrogate regions of interest using SWIR and/or fluorescence spectroscopic and imaging techniques. Unknown samples detected in regions of interest may be further interrogated using a combination of Raman and LIBS techniques to identify the unknown samples. Structured illumination may be used to interrogate an unknown sample. Data sets generated during interrogation may be compared to a reference database comprising a plurality of reference data sets, each associated with a known material. The system and method may be used to identify a variety of materials including: biological, chemical, explosive, hazardous, concealment, and non-hazardous materials.
A system and method for detecting explosives and explosive residues. A region of interest is surveyed using a video capture device to thereby identify a target area wherein the target area comprises an unknown material. The target area is interrogated using SWIR spectroscopic methods to form a SWIR hyperspectral image of the target area. The SWIR hyperspectral image is analyzed to thereby identify the unknown material.
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
78.
System and method for combined Raman and LIBS detection
A system and method for detection and identification of unknown samples using a combination of Raman and LIBS detection techniques. A first region of a sample and a second region of a sample are illuminated using structured illumination to thereby generate a first plurality of interacted photons and a second plurality of interacted photons. This first plurality and second plurality of interacted photons may be passed through a fiber array spectral translator device. Said first plurality of interacted photons are assessed using Raman spectroscopy to thereby generate a Raman data set. Said second plurality of interacted photons are assessed using LIBS spectroscopy to thereby generate LIBS data set. These data sets may be analyzed to identify the sample. These data sets may also be fused for further analysis.
A system and method for the detection and identification of explosives and explosive residues using a combination of SWIR, Raman, and LIBS spectroscopy techniques, including imaging. A region of interest may be surveyed to identify a target area, wherein the target area comprises at least one unknown material. This surveying may be accomplished using visible imagery or SWIR imagery. The target area may be interrogated using Raman spectroscopy and LIBS spectroscopy to identify the unknown material. SWIR techniques may also be used to interrogate the target area. Fusion algorithms may also be applied to visible images, SWIR data sets, Raman data sets, and/or LIBS data sets.
A system and method for performing multispectral color addition imaging. An optical image is obtained for a sample scene comprising one or more target materials. Spectroscopic data is obtained for one or more target materials. A first and second waveband of interest are obtained for one or more target materials. A ratio of the first and second wavebands of interest is obtained and compared to one or more ranges of threshold values. Based on this comparison, a result is displayed wherein this result comprises a pseudo color overlay on said optical image. The pseudo color image may comprise one or more pseudo colors assigned to one or more target materials so as to differentiate and identify the target materials present in the sample scene.
A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.
In one embodiment, the disclosure relates to a method for interrogating a sample by: illuminating a first region of the sample with a first illumination pattern to obtain a plurality of first sample photons; illuminating a second region of the sample with a second illumination pattern to obtain a plurality of second sample photons; processing the plurality of first sample photons to obtain a characteristic atomic emission of the first region and processing the plurality of second sample photons to obtain a Raman spectrum; and identifying the sample through at least one of the characteristic atomic emission of the first region or the Raman spectrum of the second region of the sample.
System and method for spatially and spectrally parallelized FAST. A sample is illuminated to thereby produce interacted photons. The photons are passed through a filter and received at a two-dimensional end of a FAST device wherein said FAST device comprises a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack so as to effectively convert a two-dimensional array of optical fibers into a curvilinear field of view, and wherein said two-dimensional array of optical fibers is configured to receive said photons and transfer said photons out of said fiber array spectral translator device and to a spectrograph through said one-dimensional fiber stack wherein said one-dimensional fiber stack comprises at least two columns of fibers spatially offset in parallel at the entrance slit of said spectrograph. The photons are then detected at a detector to thereby obtain a spectroscopic data set representative of the sample.
A method for generating an image of a sample that is informative of the disease state of a cell in the sample. A sample including the cell is irradiated with monochromatic light. The Raman scattered light is assessed. A digital brightfield image of the Raman scattered light is generated and combined with the Raman scattered light emitted by the cell whereby the Raman scattered light is informative of the disease state of the cell in the sample. The method can also be used to determine the metabolic activity of the cell, the inflammatory status of the cell and/or the infected status of the cell in the sample.
A sample is illuminated to thereby generate a plurality of first interacted photons selected. The first interacted photons are assessed using a visible imaging device to thereby determine an area of interest in the sample. The area of interest is illuminated to thereby generate a plurality of second interacted photons. The second interacted photons are assessed using a spectroscopic device to thereby generate a SWIR data set representative of said area of interest. A database is searched wherein said database comprises a plurality of known SWIR data sets associated with an explosive material. The data sets comprise at least one of: a plurality of SWIR spectra and a plurality of spatially accurate wavelength resolved SWIR images. An explosive material in the area of interest is thereby identified as a result of the search.
System and method for determining a disease state of a sample. A sample is positioned in a field of view and a first spectroscopic data set is obtained. The positional information is stored and the sample is treated with a contrast enhancing agent. The sample is repositioned in the field of view and a digital image is obtained. The spectroscopic data is linked with the digital image and a database comprising representative spectroscopic data sets is searched to classify the disease state of the sample. The disclosure also provides for the step of obtaining a processed derivative image and searching a database comprising representative processed derivative images to classify a disease state of the sample.
System and method for assessing the occurrence of an unknown substance in a sample that comprises multiple entities. A reference library is provided comprising a plurality of reference data sets representative of at least one known substance. A first feature of the entities is assessed wherein the first feature is characteristic of the unknown substance. A region of interest is selected wherein the region of interest comprises at least one entity exhibiting the first feature. A spatially accurate wavelength resolved Raman image is obtained wherein each pixel in the image is the Raman spectrum of the sample at the corresponding location. The spatially accurate wavelength resolved image is assessed to thereby identify the unknown substance.
System and method for structured illumination and collection for improved optical confocality of raman fiber array spectral translator imaging and interactive raman probing
The disclosure relates generally to methods and apparatus for using telescope optics and a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample.
A system and method to distinguish normal cells from cells having undergone a biochemical change. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference spectral data sets for normal cells and a second plurality of reference spectral data sets for cells having undergone a biochemical change. A sample is irradiated to generate a target spectral data set based on photons absorbed, reflected, emitted, or scattered by the sample. The target spectral data set is transformed into a pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, cells having undergone a biochemical change, and combinations thereof. The method includes treating the sample with a pharmaceutical agent prior to irradiating the sample and using the classification to assess the efficiency of the pharmaceutical agent.
A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.
A system and method of determining an attribute of a biological tissue sample or a drug delivery device. A sample is illuminated with substantially monochromatic light to thereby generate Raman scattered photons. The Raman scattered photons are assessed to thereby generate a spectroscopic data set wherein said spectroscopic data set comprises at least one of: a Raman spectra and a spatially accurate wavelength resolved image. The spectroscopic data set is evaluated to determine at least one of: an attribute of a biological tissue sample and a drug delivery device. In one embodiment, the biological tissue comprises arterial tissue. In another embodiment, the drug delivery device is a drug-eluting stent. In another embodiment, Raman chemical imaging can be used to evaluate a sample and identify at least one of: the tissue, a drug, a drug delivery device, and a matrix associated with a drug delivery device.
A system and method of detecting explosive compounds located on a sample. The sample is irradiated with animal-safe ultra-violet radiation generating a fluorescence data set. A fluorescence database is searched based on the fluorescence data set in order to identify a known fluorescence data set. If the searching of the fluorescence database identifies a known fluorescence data set, an area of interest in the sample is identified based on the known fluorescence data set identified in the fluorescence database searching. The area of interest is irradiated with substantially monochromatic radiation to generate a Raman data set of the area of interest. A Raman database is searched based on the Raman data set in order to identify a known Raman data set. An explosive compound in the area of interest is identified based on the known Raman data set identified by searching the Raman database.
A system and method for depositing a sample of a threat agent is deposited onto a substrate. The threat agent is identified substantially coincident in time with the depositing of the sample of the threat agent onto the substrate.
A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.
The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
A system and method of correlating Raman measurements with digital images of a sample so as to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. The treated sample is repositioned in the spectroscopic device's field of view and a digital image of the treated sample is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample having well characterized pathology, which matches the sample's spectroscopic data set.
A system and method to provide a diagnosis of the renal disease state of a test renal sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known renal sample and an associated known renal disease state. A test renal sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a renal disease state of the test renal sample is provided. The renal disease state includes renal oncocytoma or chromophobe renal carcinoma disease state.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
98.
DISTINGUISHING BETWEEN INVASIVE DUCTAL CARCINOMA AND INVASIVE LOBULAR CARCINOMA USING RAMAN MOLECULAR IMAGING
A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
99.
System and method for chemical imaging of microarrays
The disclosure relates to systems and method for chemical imaging of microarrays. In one embodiment, the disclosure relates to a system for simultaneous spectral imaging of a plurality of samples arranged on an array. The system includes an illumination source for providing illuminating photons to said plurality of samples, the illuminating photons interacting with each of the plurality of samples to emit interacted photons; an array for receiving said plurality of samples, the array having an external dimension such that the samples are within a simultaneous field of view of the optical device; an optical device for collecting the interacted photons and directing the photons to an imaging device, the imaging device simultaneously forming a plurality of images corresponding to each of the plurality of samples.
A system and method to obtain a variable field of view (FOV) of a sample without requiring an increase in an imaging CCD array size. In a fiber array spectral translator (FAST) based chemical imaging system, the fibers in the fiber bundle may be organized in different 2D “zones”. Each zone may include a predetermined number of fibers. Each 2D zone of fibers at the signal input end is organized as a separate linear array (1D) at the spectrometer slit input end. Depending on the user-selected FOV, one or more zones of fibers may be selected for signal input (into the spectrometer) by a motorized mobile slit port or linear translating stage, which will sequentially scan output from each selected linear fiber array into the spectrometer slit. The user can switch from one FOV size to another, thereby activating the linear translating stage to gather signals from appropriate linear fiber arrays corresponding to fiber zones associated with the selected FOV. A CCD imager may be used to collect optical data and generate 2D spatially accurate wavelength resolved images of the user-selected FOV.
