A method for fabricating a protonic ceramic energy device includes: coating an electrolyte layer on an anode layer; and densifying the electrolyte layer by a rapid laser reactive sintering (RLRS) process on the electrolyte layer and/or the anode layer to form a half-cell comprising a dense electrolyte and a porous anode.
Prunus persica) denominated ‘EveRes Ruby’ can be distinguished by its firm fruit with slow softening, but eventually melting yellow flesh, early to mid ripening season, large size, attractive appearance, high red skin color, excellent fruit quality, good flavor, and fruit resistance to bacterial spot disease.
Prunus persica) cultivar denominated ‘CaroRes Wonder’ can be distinguished by its melting yellow flesh, early ripening season, large size, attractive appearance, high red skin color, excellent fruit quality, good flavor, fruitlet tolerance to late spring frost, and resistance to bacterial spot disease.
Provided are methods of isolating prebiotic carbohydrates and compositions thereof. The methods provide for high concentrations of non-digestible prebiotic carbohydrate. The methods may include a number of processing steps, including heat treating, isolating water-soluble prebiotic carbohydrates, removing protein, and further isolating non-digestible starch-free prebiotic carbohydrates using enzymes.
This invention is directed to a monoclonal antibody or an antigen binding fragment thereof targeting the expression and function of CYP1A1 with cross reactivity across the vertebrate taxa. This invention is also directed to nucleic acid molecules, vectors, host cells and compositions comprising the same, as well as methods for use of the same and for producing the same.
An electroprinting system having a voltage generator that produces a signal, a drop-on- demand (DOD) droplet generator actuated by the signal of the voltage generator, the drop generator having a wire for submersion into a viscous fluid, a power supply connected to the wire for supplying current to the DOD droplet generator, and a grounded collector for collection of the droplet generated by the DOD droplet generator. The drop-on-demand (DOD) droplet generator has a wire for plunging or threading through a meniscus of a viscous fluid, and an applied electrical potential to form a droplet from the viscous fluid. A method of electroprinting of a viscous fluid is also provided.
A method of measuring temperature includes positioning an optical fiber in contact with an object or in an environment having a temperature to be determined, where the optical fiber comprises a core surrounded by a cladding; the core comprises an alkaline-earth fluorosilicate glass including defects, and the cladding comprises a silica glass. Infrared light is supplied to the optical fiber, thereby electronically exciting the defects. Green light emitted from the defects is detected, and an intensity value of the green light is obtained and converted to a temperature value for the optical fiber, whereby the temperature of the object or environment is determined. The green light may be detected along a length of the optical fiber, and a plurality of intensity values may be converted to a plurality of temperature values along the fiber length, thereby obtaining a distributed measurement of the temperature of the object or environment.
G01K 11/3213 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in transmittance, scattering or luminescence in optical fibres at discrete locations in the fibre, e.g. using Bragg scattering using changes in luminescence, e.g. at the distal end of the fibres
8.
FUNCTIONALIZED CHROMOPHORIC POLYMER DOTS AND BIOCONJUGATES THEREOF
The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
This disclosure relates to using compounds disclosed herein to treat or prevent cocaine use disorder, cocaine toxicity, or other drug related disorders. In certain embodiments, this disclosure relates to methods of treating drug addiction or to help prevent relapse. In certain embodiments, this disclosure relates to methods of treating or preventing cocaine use disorder, cocaine toxicity, or other use disorders comprising administering an effective amount of a compound disclosed herein, such as ibrutinib, [(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one], derivative, or salt thereof to a subject in need thereof. In certain embodiments, the compound is a Bruton's tyrosine kinase (BTK) inhibitor.
An electroprinting system having a voltage generator that produces a signal, a drop-on-demand (DOD) droplet generator actuated by the signal of the voltage generator, the drop generator having a wire for submersion into a viscous fluid, a power supply connected to the wire for supplying current to the DOD droplet generator, and a grounded collector for collection of the droplet generated by the DOD droplet generator. The drop-on-demand (DOD) droplet generator has a wire for plunging or threading through a meniscus of a viscous fluid, and an applied electrical potential to form a droplet from the viscous fluid. A method of electroprinting of a viscous fluid is also provided.
B41J 2/045 - Ink jet characterised by the jet generation process generating single droplets or particles on demand by pressure, e.g. electromechanical transducers
A single phase, organic-inorganic sol-gel with controlled rheology that can be solidified readily and converted into a ceramic material is provided. The organic-inorganic sol-gel may be uranium-based or cerium-based. Highly spherical ceramic microspheres such as uranium or cerium gel microspheres are fabricated and are able to be converted to homogeneous ceramics after thermal decomposition at high temperatures. Pure phase UC2 can be obtained upon carbothermal reaction. Pure phase U2N3 can also be obtained after converting UC2 to U2N3.
B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
B01J 13/02 - Making microcapsules or microballoons
C04B 35/524 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbon, e.g. graphite obtained from polymer precursors, e.g. glass-like carbon material
C04B 35/56 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbides
C04B 35/58 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on borides, nitrides or silicides
C04B 41/00 - After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
12.
NON-ISOCYANATE POLYURETHANES FROM BIO-BASED POLYOLS
Bio-based polymer precursors and non-isocyanate polyurethanes (NIPU) and non-isocyanate polyurethane foams (NIPUF) that can be formed from the precursors, as well as methods for the synthesis of the precursors and the polyurethane products are described. The bio-based polymer precursors are formed through functionalization of a bio-based polyol, e.g., lignin, with cyclic carbonates. The bio-based polyol starting materials need not be pre-processed and can include Kraft lignin. NIPU/NIPUF can be synthesized through a ring opening curing reaction of cyclic carbonates of the bio-based polyol precursor with diamines. The carbonates and diamines can include non-toxic bio-based carbonates.
A modular polynomial multiplier includes a plurality of processing elements. Each includes a multiplication unit, an addition unit and a delay unit. The addition unit has an input connected to the output of the multiplication unit. The delay unit is connected to the output of the addition unit delays values by one clock cycle. The first input of the multiplication unit of each processing element carries a respective coefficient of a first polynomial and the second input of the multiplication unit of each processing element is connected to one of an input line carrying a sequence of coefficients of a second polynomial having n coefficients and a delay line carrying the sequence of coefficients of the second polynomial delayed by n clock cycles and negated.
G06F 7/72 - Methods or arrangements for performing computations using a digital non-denominational number representation, i.e. number representation without radix; Computing devices using combinations of denominational and non-denominational quantity representations using residue arithmetic
G06F 7/544 - Methods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using unspecified devices for evaluating functions by calculation
15.
CHANNELED FIBERS IN SEPARATION OF BIOLOGICALLY ACTIVE NANOPARTICLES
A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)
B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
Disclosed are methods for formation of a fiber and fibers that can be formed according to the methods. Formation methods incorporate a “molten core flux method” whereby a solid primary core material is combined with a solid secondary flux material in a multi-phase preform core. In some embodiments, the multi-phase preform core has a liquidus temperature that is reduced relative to the melting temperature of at least the primary core material. A homogeneous liquid melt of the preform core can exhibit a sufficiently low vapor pressure such that a fiber preform incorporating the materials in the core can be thermally drawn. Upon cooling and solidification of the homogeneous core melt, separation of the core components can occur via recrystallization, with one phase being that of the desired primary core material. Methods can be particularly beneficial for forming fibers incorporating high vapor pressure semiconductor materials, e.g., ZnSe or GaAs, in the fiber core.
G02B 1/02 - Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of crystals, e.g. rock-salt, semiconductors
C03C 27/00 - Joining pieces of glass to pieces of other inorganic material; Joining glass to glass other than by fusing
Provided is an apparatus for measuring the ammonia concentration in exhaled breath and a method for measuring the ammonia concentration in exhaled breath. The apparatus comprises a sample collection portion, capable of capturing exhaled breath to control the volume of exhaled breath, a pressure gauge for the control of the flow rate of exhaled breath, a small diameter inner tube oriented in a perpendicular direction to the colorimetric sensor to focus the exhaled breath stream onto the central region of the sensor, and an analysis portion capable of receiving said exhaled breath from said sample collection portion. The analysis portion comprises a colorimetric sensor comprising an active component on a substrate. The colorimetric sensor changes color proportional to the ammonia concentration in said exhaled breath.
Integratable treatment devices, assemblies including a treatment device, at least one anchor, and a tether coupled thereto, and various methods and devices for inserting such devices and assemblies are disclosed herein. The treatment devices can be made of an integratable material that is not fully bioresorbable but promotes native tissue growth in and around the material. Certain methods involve first inserting at least one anchor and then advancing a treatment device via a tether coupled to the at least one anchor. Further various insertion devices that can be used to implant any of the treatment devices herein using any of the methods herein are disclosed.
A61F 2/44 - Joints for the spine, e.g. vertebrae, spinal discs
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
Integratable treatment devices, assemblies including a treatment device, at least one anchor, and a tether coupled thereto, and various methods and devices for inserting such devices and assemblies are disclosed herein. The treatment devices can be made of an integratable material that is not fully bioresorbable but promotes native tissue growth in and around the material. Certain methods involve first inserting at least one anchor and then advancing a treatment device via a tether coupled to the at least one anchor. Further various insertion devices that can be used to implant any of the treatment devices herein using any of the methods herein are disclosed.t:2
A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
A61F 2/44 - Joints for the spine, e.g. vertebrae, spinal discs
20.
ACTIVATED CARBON FOR REMOVAL OF TASTE AND ODOR COMPOUNDS FROM WATER
In general, the present disclosure is directed to a soyhull-based activated carbon. The soyhull-based activated carbon comprises a Brunauer-Emmett-Teller (BET) surface area of from about 750 m2/g to about 2900 m2/g and a micropore volume of from about 0.50 cm3/g to about 1.2 cm3/g.
B01J 20/20 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
B01J 20/30 - Processes for preparing, regenerating or reactivating
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
21.
TOPOLOGY AGNOSTIC DETECTION AND LOCATION OF FAULT IN DC MICROGRID USING LOCAL MEASUREMENTS
Systems and methods of determining fault location on a DC microgrid feeder need to be extremely fast to protect the circuit breaker and converter-source components. This disclosure develops a seminal theoretical foundation for fast fault location on a DC feeder that uses only single-ended local measurements in time domain. The theory provides a closed-form deterministic solution for fault location, making the resulting fault location method agnostic to system-topology and immune to fault resistance. The theory is developed with ideal DC voltage sources and is extended to practical converter-sources. The performance of the resulting method is demonstrated by simulating a DC feeder with converters connected at both ends, modeled in PSCAD (power systems computer-aided design).
H02H 3/20 - Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition, with or without subsequent reconnection responsive to excess voltage
Various cardio tissue testing wells with an actuable attachment structure therein, and testing systems incorporating such wells therein. The various well embodiments can include an actuable attachment structure that is actuated by external energy, such as a magnetic field, fluidic pressure, or electrical actuation. The various system embodiments can include a controller, a power source, and a testing plate containing a plurality of wells, wherein each well includes an actuable attachment structure.
Various cardio tissue testing wells with an actuable attachment structure therein, and testing systems incorporating such wells therein. The various well embodiments can include an actuable attachment structure that is actuated by external energy, such as a magnetic field, fluidic pressure, or electrical actuation. The various system embodiments can include a controller, a power source, and a testing plate containing a plurality of wells, wherein each well includes an actuable attachment structure.
Disclosed herein is a system for evaluating a user during a physical cannulation simulation. The system includes a physical cannulation simulator and one or more sensors configured to measure data during the physical cannulation simulation by the user using the physical cannulation simulator. The system further includes one or more processors configured to receive the data measured by each of the one or more sensors and calculate metrics using the data. The one or more processors are further configured to apply a model to the metrics to determine a composite simulation success score and compare the composite simulation success score to a threshold score. In response to comparing the composite simulation success score to the threshold score, the one or more processors are configured to output an indication of one or more of an absolute performance or a relative performance for the first user during the physical cannulation simulation.
Methods and systems for the separation of hydrogen isotopes from one another are described. Methods include utilization of a hydrogen isotope selective separation membrane that includes a hydrogen isotope selective layer (e.g., graphene) and a hydrogen ion conductive supporting layer. An electronic driving force encourages passage of isotopes selectively across the membrane at an elevated separation temperature to enrich the product in a selected hydrogen isotope.
A system for monitoring an analyte concentration in liquid is provided. The system includes a coupon comprising an absorbent body with a window through the absorbent body wherein the liquid is maintained in said window by capillary action and surface tension. A reactant is in the absorbent body wherein the reactant is capable of diffusing into the window to react with an analyte in the liquid, or the reactant is able to react with the analyte within the coupon itself, with color-indicating by-products of the reaction diffusing into the window, wherein the analyte is present in an analyte concentration, to form a reactant with a color wherein the color has an intensity which correlates to the analyte concentration. A light source is provided which is capable of passing light into the window wherein the light is attenuated by the color proportional to the analyte concentration to form attenuated light. A detector is provided which is capable measuring an intensity of the attenuated light. Alternatively, the color change can be read by eye and compared to a color chart relating the color to an analyte concentration.
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 33/493 - Physical analysis of biological material of liquid biological material urine
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
To achieve high-power single transverse mode laser, we here propose a supersymmetry (SUSY)-based triple-ridge waveguide semiconductor laser structure, which is composed of an electrically pumped main broad-ridge waveguide located in the middle and a pair of lossy auxiliary partner waveguides. The auxiliary partner waveguides are designed to provide dissipative modes that can phase match and couple with the higher-order modes in the main waveguide. By appropriately manipulating the gain-loss discrimination of the modes in the laser cavity, one can effectively suppress all the undesired higher-order transverse modes while keeping the fundamental one almost unaffected, thereby ensuring stable single-mode operation with a larger emitting aperture and accordingly a higher output power than a conventional single-transverse-mode ridge waveguide diode laser.
Systems and methods of signal processing for sensors are disclosed. Signal processing methods and systems demodulate the optical interference phase of cascaded individual optical fiber intrinsic Fabry-Perot interferometric sensors in a coherent microwave-photonic interferometry distributed sensing system. The chirp effect of an electro-optic modulator (EOM) is used to create a quasi-quadrature optical interference phase shift between two adjacent pulses which correspond to two adjacent reflection points in the time domain. The phase shift can be controlled by adjusting the bias voltage that is applied to the EOM. The interference phase is calculated by elliptically fitting the phase shift. The interference phase change is proportional to the optical path difference (OPD) change of the interferometer, and the sign can be used to differentiate the increase or decrease of the OPD. The approach shows good linearity, high resolution, and large dynamic range for distributed strain sensing.
G01D 5/353 - Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells influencing the transmission properties of an optical fibre
The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
C30B 7/04 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent using aqueous solvents
This invention relates to three-dimensional myocardial infarct organoids and methods of making and using the same for screening compounds that improve cardiac function and compounds that diminish cardiac function.
Methods for synthesis of high surface area porous silicon-based materials and structures that can be formed according to the methods are described. Methods are scalable and capable of producing large quantities of the high surface area materials with high efficiency. The high surface area products can be in the form of a 3D network of interconnected arms or quills with multimodal porosity including high level pores between and among arms, hollow cores of the arms of the network, and pores through the walls of the arms of the network.
Disclosed herein are various organic plant protein compositions including a balanced amino acid profile with no chemical residues. Further disclosed herein are methods for creating organic plant protein compositions from organic plant material(s). In some embodiments, the organic plant protein composition includes pea protein, sorghum protein, organic baking powder, and organic vinegar.
A23J 1/14 - Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from press-cake or oil-bearing seeds
A23P 10/40 - Making free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
A23J 1/00 - Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
A23J 1/12 - Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from cereals, wheat, bran, or molasses
Disclosed herein are various organic plant protein compositions including a balanced amino acid profile with no chemical residues. Further disclosed herein are methods for creating organic plant protein compositions from organic plant material(s). In some embodiments, the organic plant protein composition includes pea protein, sorghum protein, organic baking powder, and organic vinegar.
Disclosed herein are various organic plant protein compositions including a balanced amino acid profile with no chemical residues. Further disclosed herein are methods for creating organic plant protein compositions from organic plant material(s). In some embodiments, the organic plant protein composition includes pea protein, sorghum protein, organic baking powder, and organic vinegar.
A23J 1/14 - Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from press-cake or oil-bearing seeds
A23J 1/12 - Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from cereals, wheat, bran, or molasses
B01D 21/26 - Separation of sediment aided by centrifugal force
Antibodies and antigen binding fragments thereof that specifically recognize and bind an epitope of elastin that is exposed and accessible in degraded elastic fiber are described. The antibodies and/or antigen binding fragments can be operably linked to a secondary component, including biologically active agents such as therapeutics and/or imaging agents. Optionally, the antibodies and/or antigen binding fragments thereof can be attached to a surface of a carrier, such as a particle, for specific binding and delivery of the carried agents to degraded elastic fiber.
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
Systems and methods of producing unclonable devices are disclosed. Robust optical physical unclonable function devices use disordered photonic integrated circuits. Optical physical unclonable functions based on speckle patterns, chaos, or ‘strong’ disorder are so far notoriously sensitive to probing and/or environmental variations. A presently disclosed optical physical unclonable function is designed for robustness against fluctuations in optical angular/spatial alignment, polarization, and temperature using an integrated quasicrystal interferometer which sensitively probes disorder. All modes are engineered to exhibit approximately the same confinement factor in the predominant thermo-optic medium (e.g., silicon) and for constraining the transverse spatial-mode and polarization degrees of freedom. Silicon photonic quasicrystal interferometry is used for secure hardware applications.
G06F 21/75 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer to assure secure computing or processing of information by inhibiting the analysis of circuitry or operation, e.g. to counteract reverse engineering
This disclosure relates to using compounds disclosed herein to treat or prevent cocaine use disorder, cocaine toxicity, or other drug related disorders. In certain embodiments, this disclosure relates to methods of treating drug addiction or to help prevent relapse. In certain embodiments, this disclosure relates to methods of treating or preventing cocaine use disorder, cocaine toxicity, or other use disorders comprising administering an effective amount of a compound disclosed herein, such as ibrutinib, [(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one], derivative, or salt thereof to a subject in need thereof. In certain embodiments, the compound is a Bruton's tyrosine kinase (BTK) inhibitor.
A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K 31/4439 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
40.
Method, system and application for 3D molecular diffusion tensor measurement and structural imaging
Herein are described data acquisition systems and methods applying such systems to determine three-dimensional (3D) diffusion tensors, and simultaneously, to perform 3D structure imaging. Example data acquisition systems can include computing systems in communication with modified light sheet microscopes that are configured for high-speed volumetric imaging to record 3D diffusion processes and high-resolution 3D structural imaging.
A method for fabricating a protonic ceramic energy device includes: coating an electrolyte layer on an anode layer; and densifying the electrolyte layer by a rapid laser reactive sintering (RLRS) process on the electrolyte layer and/or the anode layer to form a half-cell comprising a dense electrolyte and a porous anode.
The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation and is useful for bioprinting.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
G01N 33/74 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones
A system for monitoring an analyte concentration in liquid is provided. The system includes a coupon comprising an absorbent body with a window through the absorbent body wherein the liquid is maintained in said window by capillary action and surface tension. A reactant is in the absorbent body wherein the reactant is capable of diffusing into the window to react with an analyte in the liquid, or the reactant is able to react with the analyte within the coupon itself, with color-indicating by-products of the reaction diffusing into the window, wherein the analyte is present in an analyte concentration, to form a reactant with a color wherein the color has an intensity which correlates to the analyte concentration. A light source is provided which is capable of passing light into the window wherein the light is attenuated by the color proportional to the analyte concentration to form attenuated light. A detector is provided which is capable measuring an intensity of the attenuated light. Alternatively, the color change can be read by eye and compared to a color chart relating the color to an analyte concentration.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 33/493 - Physical analysis of biological material of liquid biological material urine
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
44.
PLANT TISSUE CULTURE DEVICES AND METHODS OF CULTURING AND HARVESTING PLANT SHOOT TIPS
The present disclosure describes a method of culturing and harvesting plant shoot tips. The method includes providing a sterile vessel configured to hold at least one plant with one or more root masses and a first set of shoot tips, cutting across a base of the shoot tips with the one or more root masses held in the vessel to cut a first plurality of cut shoot tips at a first time; then growing a second set of shoot tips from the one or more root masses in the vessel; and then cutting across the one or more root masses held in the vessel to cut a second plurality of cut shoot tips. Plant tissue culture devices are also described.
Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).
A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
Devices and methods for super-resolution optical microscopy are described. Devices include an optical multiplexer to develop an excitation/illumination optical beam that includes alternating pulses of different profiles. Devices also include a signal processing unit to process a sample response to excitation/illumination beam and to subtract the neighboring pulses of the different profiles from one another on a pulse-to-pulse basis. Devices can be incorporated in existing confocal microscopy designs. As the subtraction effectively reduces the volume of the response signal, the spatial resolution of the systems can be markedly improved as compared to previously known optical microscopy approaches.
Apparatus include an atmospheric pressure glow discharge (APGD) analyte electrode defining an analyte discharge axis into an APGD volume, and a plurality of APGD counter electrodes having respective electrical discharge ends directed to the APGD volume, wherein the APGD analyte electrode and the APGD counter electrodes are configured to produce an APGD plasma in the APGD volume with a voltage difference between the APGD analyte electrode and one or more of the AGPD counter electrodes. An electrode can be integrated into an ion inlet. Apparatus can be configured to perform auto-ignition and/or provide multi-modal operation through selectively powering electrodes. Electrode holder devices are disclosed. Related methods are disclosed.
G01N 21/67 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence using electric arcs or discharges
G01N 27/68 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using electric discharge to ionise a gas
G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode
H01J 47/12 - Neutron detector tubes, e.g. BF3 tubes
H01J 61/54 - Igniting arrangements, e.g. promoting ionisation for starting
Apparatus include an atmospheric pressure glow discharge (APGD) analyte electrode defining an analyte discharge axis into an APGD volume, and a plurality of APGD counter electrodes having respective electrical discharge ends directed to the APGD volume, wherein the APGD analyte electrode and the APGD counter electrodes are configured to produce an APGD plasma in the APGD volume with a voltage difference between the APGD analyte electrode and one or more of the AGPD counter electrodes. An electrode can be integrated into an ion inlet. Apparatus can be configured to perform auto-ignition and/or provide multi-modal operation through selectively powering electrodes. Electrode holder devices are disclosed. Related methods are disclosed.
This system is designed to color correct a targeted color or colors in a video stream comprising: a computer device having a computer readable medium; and, a set of computer readable instructions embodied on the computer readable medium that are configured to: receive a dataset that includes one or more pairs of video frames where a first frame of the pair of an incorrect color frame and the second frame of the pair is a color correct frame, using a machine learning module to create a mask according to the dataset, receiving an image, correcting the image, and, transmitting the corrected image to a display.
H04N 5/232 - Devices for controlling television cameras, e.g. remote control
G06T 7/90 - Determination of colour characteristics
G09G 3/20 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix
51.
Precision control through stitching for material properties of textiles
This system is directed to a computerized system for development of textiles with modified physical properties through stitching and can include a set of non-transitory computer readable instructions configured for: receiving a design pattern representing desired physical properties of a textile having a higher stiffness area and a lower stiffness area; developing a contiguous stitching pattern constrained by a pattern perimeter boundary and having a continuous stitching path, developing a first stiffness area within the contiguous stitching pattern having a first area of density, developing a second stiffness area within the contiguous stitching pattern having a second area of density wherein the first area of density has more stitch density than the second area of density, and transmitting the contiguous stitching pattern to an embroidery machine configured to provide a textile having the contiguous stitching pattern incorporating into the textile.
G05B 19/4155 - Numerical control (NC), i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme
52.
Methods for targeted delivery of agents to degraded elastic fibers
Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers, and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers. The delivery agents may be utilized for targeted delivery of biologically active compounds to degraded elastic fibers so as to maintain and/or regenerate the elastin component of connective tissue, and to prevent further degradation and/or rehabilitate the structural architecture of the connective tissue.
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
53.
Radiographic discernable sensors and orthopedic applications for same
Implantable sensors for determining bone health that can be utilized in conjunction with orthopedic implants are described. The sensors can include passive strain gauges or passive chemical sensors that can be read by radiographic imaging techniques. Sensors can be affixed to implantable support devices so as to non-invasively monitor the effect of load on the implant; for instance, to provide a quantitative assessment of when a fracture is sufficiently healed to allow safe weight-bearing upon the limb. Alternatively, sensors can monitor the health of a local implant area; for instance, to monitor the implant area of early stage infection or healing of a fusion procedure.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis
G01L 1/25 - Measuring force or stress, in general using wave or particle radiation, e.g. X-rays, neutrons
A61B 6/12 - Devices for detecting or locating foreign bodies
A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
Antibodies and antigen binding fragments thereof that specifically recognize and bind an epitope of elastin that is exposed and accessible in degraded elastic fiber are described. The antibodies and/or antigen binding fragments can be operably linked to a secondary component including biologically active agents such as therapeutics and/or imaging agents. Optionally, the antibodies and/or antigen binding fragments thereof can be attached to a surface of a carrier, such as a particle, for specific binding and delivery of the carried agents to degraded elastic fiber.
This system and method of for providing a tunable orbital angular momentum system for providing higher order Bessel beams comprising: an acousto-optical deflector configured to receive an input beam, deflect a first portion of the input beam a first deflection angle relative to an axis of propagation and along an optical axis and deflect a second portion of the input beam a second deflection angle relative to the optical axis; a line generator disposed along the optical angle for receiving the first portion and the second portion of the input beam and provide an elliptical Gaussian mean; a log-polar optics assembly disposed along the optical angle for receiving the elliptical Gaussian beam and wrapping the elliptical Gaussian beam with an asymmetric ring; and, a Fourier lens configured to receive the wrapped elliptical Gaussian beam.
An improved material, preferably a biomaterial, is provided which is the reaction product of S8 and a free fatty acid or free fatty acid-containing material, preferably in the presence of metal. The improved material can be made by a method comprising reacting S8 with a free fatty acid to obtain a FFA/S8 composite and shaping the FFA/S8 composite into a solid form. The solid form of said FFA/S8 is melted to form melted FFA/S8 and the melted FFA/S8 is optionally applied as a coating on a surface, used as an adjacent material to a surface or the FFA/S8 composite itself is shaped thereby forming a device and preferably a medical device.
A force generator applying a force load against a facemask. A first load cell carrying a first portion of the facemask at an attachment point of the facemask where the facemask is attachable to a helmet. A second load cell carrying a second portion of the facemask at another attachment point of the facemask where the facemask is attachable to a helmet. A first attachment platform carrying the first load cell, wherein the first attachment platform is laterally movable in at least two degrees of freedom. A second attachment platform carrying the second load cell, wherein the second attachment platform is laterally movable in at least two degrees of freedom. The force generator directs the contact plate against the facemask to cause a horizontal deformation of the facemask and a lateral movement of the attachment platforms to allow for repeatable force load testing on a single facemask.
C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
59.
PLANT TISSUE CULTURE DEVICES AND METHODS OF CULTURING AND HARVESTING PLANT SHOOT TIPS
The present disclosure describes a method of culturing and harvesting plant shoot tips. The method includes providing a sterile vessel configured to hold at least one plant with one or more root masses and a first set of shoot tips, cutting across a base of the shoot tips with the one or more root masses held in the vessel to cut a first plurality of cut shoot tips at a first time; then growing a second set of shoot tips from the one or more root masses in the vessel; and then cutting across the one or more root masses held in the vessel to cut a second plurality of cut shoot tips. Plant tissue culture devices are also described.
Materials and methods for prevention of biofouling that incorporate the presence of a conotoxin peptide on a surface are described. The conotoxin peptide is either directly or indirectly adhered to the surface and interferes with the ability of biofouling organisms to settle on the surface.
The present disclosure describes a method of culturing and harvesting plant shoot tips. The method includes providing a sterile vessel configured to hold at least one plant with one or more root masses and a first set of shoot tips, cutting across a base of the shoot tips with the one or more root masses held in the vessel to cut a first plurality of cut shoot tips at a first time; then growing a second set of shoot tips from the one or more root masses in the vessel; and then cutting across the one or more root masses held in the vessel to cut a second plurality of cut shoot tips. Plant tissue culture devices are also described.
Ion exchange membranes (e.g., anion exchange membranes) and methods of using the membranes are described. The ion exchange membranes are multi-modal ion exchange membranes containing a plurality of multi-modal exchange ligands. The membranes can achieve high dynamic and equilibrium binding capacities at solution conductivities typical for production of biologics (e.g., greater than about 10 mS/cm) and can provide excellent binding at high flow rates. Systems incorporating the membranes can dramatically increase isolation and purification speeds. Membranes are disclosed for use in production of biologics.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 39/26 - Cation exchangers for chromatographic processes
B01J 47/014 - Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
This invention relates to three-dimensional myocardial infarct organoids and methods of making and using the same for screening compounds that improve cardiac function and compounds that diminish cardiac function.
This is a system and method for homomorphic encryption comprising: a key generation module configured to generate a secret key, a public key and a bootstrapping key; a private-key encryption module configured to generate a first ciphertext using the secret key; a public-key encryption module configured to generate a second cyphertext using the public key; a private-key decoding module configured to decode a first ciphertext, a second ciphertext and an encrypted analytic result; a homomorphic computational module configured to perform an analytical operation, according to an analytical operation request on the first ciphertext and the second ciphertext without decrypting the first ciphertext and the second ciphertext using the bootstrapping key; and, wherein the encrypted analytical result is provided by the homomorphic computational module and are encrypted with the secret key.
Foldable composite structures and methods for fabricating foldable composite structures are provided. For example, a method comprises selectively applying a rigidifying substance to a sheet of composite material to define a plurality of hinges; allowing the rigidifying substance to cure; and folding the sheet of composite material along the hinges to form the composite structure. As another example, a method comprises laying out flat a sheet of composite material; masking a plurality of hinges on the sheet; applying a polymer to a sheet face; curing the polymer; removing the masking; and folding the sheet along the hinges to form the composite structure. An exemplary foldable composite structure comprises a planar sheet of composite material folded to define a plurality of surface segments and a plurality of hinges. A portion of the hinges form peaks and the remainder of the hinges form valleys. The hinges are defined between adjacent surface segments.
B29C 53/06 - Forming folding lines by pressing or scoring
B29C 59/00 - Surface shaping, e.g. embossing; Apparatus therefor
B29C 70/30 - Shaping by lay-up, i.e. applying fibres, tape or broadsheet on a mould, former or core; Shaping by spray-up, i.e. spraying of fibres on a mould, former or core
B05D 1/32 - Processes for applying liquids or other fluent materials using means for protecting parts of a surface not to be coated, e.g. using stencils, resists
E04C 3/34 - Columns; Pillars; Struts of concrete or other stone-like material, with or without permanent form elements, with or without internal or external reinforcement, e.g. metal coverings
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
B32B 27/20 - Layered products essentially comprising synthetic resin characterised by the use of special additives using fillers, pigments, thixotroping agents
B32B 7/08 - Interconnection of layers by mechanical means
Systems and methods for detecting metal clips inserted within a portion of a body of a patient are disclosed herein. In one embodiment, a clip detector assembly includes a detector having a ferrous member, a transmitting coil around the ferrous member and configured to induce a current in the metal clip, and a receiving coil around the ferrous member and configured to receive a magnetic field generated by the current induced in the metal clip. The assembly can further include a control circuit having a band-pass filter configured to pass electrical signals induced by the magnetic field from the receiving coil that are within at most 35 kHz of a resonance frequency of the metal clip. The assembly still further includes a user notification component configured to alert a user to a location of the metal clip.
A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
67.
Circuit breaker for DC circuits using coupled induction
An improved DC circuit breaker is provided for automatically detecting and isolating a fault between a source and a ground. The DC circuit breaker comprises at least one switch, in electrical series with a first inductor between the source and a load, and a second inductor magnetically coupled to the first inductor wherein a first side of the second inductor is electrically connected to the load and a second side of the second inductor is grounded through a capacitor.
H02H 3/16 - Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition, with or without subsequent reconnection responsive to fault current to earth, frame or mass
H03K 17/687 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components by the use, as active elements, of semiconductor devices the devices being field-effect transistors
68.
Channeled fibers in separation of biologically active nanoparticles
A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)
B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
B01J 20/28 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)
B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
A61K 35/12 - Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
70.
Decellularization method and system and decellularized tissue formed thereby
Systems and methods that establish a pressure differential across a tissue wall to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time.
wxyz z wherein: A comprises an epoxy group; B comprises a hydrophobic group; C is an optional cross-linker; D of Formula I comprises a hydrophilic group; w is at least 0.1 to no more than 0.9 with the proviso that at least one of x or z is not zero; x is up to 0.9; y is up to 0.3; and z is up to 0.9.
Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one targeting moiety, at least one therapeutic agent, and/or at least one nucleic acid. Also provided herein are methods of using the multi-functional particles.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 9/00 - Drugs for disorders of the cardiovascular system
A61K 47/59 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
73.
Circuit breaker for DC circuits using coupled induction
An improved DC circuit breaker is provided for automatically detecting and isolating a fault between a source and a ground. The DC circuit breaker comprises at least one switch, in electrical series with a first inductor between the source and a load, and a second inductor magnetically coupled to the first inductor wherein a first side of the second inductor is electrically connected to the load and a second side of the second inductor is grounded through a capacitor.
H02H 3/16 - Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition, with or without subsequent reconnection responsive to fault current to earth, frame or mass
H03K 17/687 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components by the use, as active elements, of semiconductor devices the devices being field-effect transistors
A01N 37/42 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing within the same carbon skeleton a carboxylic group or a thio-analogue, or a derivative thereof, and a carbon atom having only two bonds to hetero atoms with at the most one bond to halogen, e.g. keto-carboxylic acids
A01N 49/00 - Biocides, pest repellants or attractants, or plant growth regulators containing compounds containing the group wherein m+n≥1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not p
75.
Graphene-ceramic composite membrane for hydrogen separation membranes
3-δ, where 0≤x≤0.5, 0≤y≤0.5, 0≤z≤0.5, (x+y+z)>0; 0≤δ≤0.5, and T is Yb, Sc, Ti, Nb, Ta, Mo, Mn, Fe, Co, Ni, Cu, Zn, Ga, In, or a combination thereof. In addition, the BZYCT can be present in the C-BZCYT mixture in an amount ranging from about 40% by volume to about 80% by volume. Further, a method of forming such a membrane is also provided. A method is also provided for extracting hydrogen from a feed stream.
C01B 3/50 - Separation of hydrogen or hydrogen containing gases from gaseous mixtures, e.g. purification
C04B 35/50 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on rare earth compounds
B01D 53/32 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
C04B 35/80 - Fibres, filaments, whiskers, platelets, or the like
C04B 35/52 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbon, e.g. graphite
C01F 17/206 - Compounds containing only rare earth metals as the metal element oxide or hydroxide being the only anion
Disclosed are methods and systems for determining the amount of material contained in a windrow. In particular embodiments, the methods and systems are applicable to agricultural applications, and in particular to hay yield monitoring. Systems include a remote sensing technology to determine windrow height. Remote sensing methods can include ultrasonic sensors, optical sensors, and the like. Systems can provide real time yield data.
Methods for forming carbon-based cellular structures and 3D structures that can be formed by use of the methods are described. Methods include shaping an essentially 2D sheet that includes an organic polymer to form a 3D precursor followed by heat treatment of the 3D precursor. Heat treatment carbonizes the polymer to form an amorphous carbon. A metal precursor solution can be applied to the 3D precursor, and subsequent heat treatment can form a metal carbide, metal nanoparticles, or other carbon-based materials on/in the cellular structures.
Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one targeting moiety, at least one therapeutic agent, and/or at least one nucleic acid. Also provided herein are methods of using the multi-functional particles.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
79.
COUPON DESIGN FOR ENHANCED COLOR SENSITIVITY FOR COLORIMETRIC-BASED CHEMICAL ANALYSIS OF LIQUIDS
A system for monitoring an analyte concentration in liquid is provided. The system includes a coupon comprising an absorbent body with a window through the absorbent body wherein the liquid is maintained in said window by capillary action and surface tension. A reactant is in the absorbent body wherein the reactant is capable of diffusing into the window to react with an analyte in the liquid, or the reactant is able to react with the analyte within the coupon itself, with color-indicating by-products of the reaction diffusing into the window, wherein the analyte is present in an analyte concentration, to form a reactant with a color wherein the color has an intensity which correlates to the analyte concentration. A light source is provided which is capable of passing light into the window wherein the light is attenuated by the color proportional to the analyte concentration to form attenuated light. A detector is provided which is capable measuring an intensity of the attenuated light. Alternatively, the color change can be read by eye and compared to a color chart relating the color to an analyte concentration.
G01N 21/25 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 21/29 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using visual detection
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 33/62 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving urea
G02F 1/09 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on magneto-optical elements, e.g. exhibiting Faraday effect
C30B 7/10 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by application of pressure, e.g. hydrothermal processes
G02B 27/28 - Optical systems or apparatus not provided for by any of the groups , for polarising
C01F 17/206 - Compounds containing only rare earth metals as the metal element oxide or hydroxide being the only anion
Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.
Methods for developing a decellularized tissue and biomaterials for use as biomimetic grafts or in vitro cellular scaffolds formed with the decellularized tissue are described. The biomaterials are particularly well suited for use as an intervertebral disc graft. The decellularized tissue is formed from an intervertebral disc source tissue and can be substantially decellularized and substantially free of potential immunogenic material (e.g., DNA and RNA), while maintaining ECM materials including both glycosaminoglycan and collagen.
Electrically assisted flow drill screwdriving processes (EAFDS) and devices are described. The methods can augment traditional FDS and allow for softening of metals of a stack-up, which can enable FDS joining of thicker and stronger materials such as boron steel. EAFDS methods can reduce cycle time and can be used to join thicker cross-sections with reduced installation torque. Also disclosed are fixtures for attachment to existing devices that can provide for the electrical augmentation of existing FDS processes.
F16B 5/02 - Joining sheets or plates to one another or to strips or bars parallel to them by means of fastening members using screw-thread
B25B 23/14 - Arrangement of torque limiters or torque indicators in wrenches or screwdrivers
B25B 23/147 - Arrangement of torque limiters or torque indicators in wrenches or screwdrivers specially adapted for electrically operated wrenches or screwdrivers
B21J 5/06 - Methods for forging, hammering, or pressing; Special equipment or accessories therefor for performing particular operations
F16B 25/10 - Screws performing an additional function to thread-forming, e.g. drill screws
F16B 25/00 - Screws that form threads in the body into which they are screwed, e.g. wood screws, self-tapping screws
84.
Radiographic discernable sensors and orthopedic applications for same
Implantable sensors for determining bone health are described that can be utilized in conjunction with orthopedic implants. The sensors can include passive strain gauges or passive chemical sensors that can be read by radiographic imaging techniques. Sensors can be affixed to implantable support devices so as to non-invasively monitor the effect of load on the implant for instance to provide a quantitative assessment of when a fracture is sufficiently healed to allow safe weight-bearing upon the limb. Alternatively, sensors can monitor the health of a local implant area, for instance to monitor the implant area of early stage infection or healing of a fusion procedure.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis
G01L 1/25 - Measuring force or stress, in general using wave or particle radiation, e.g. X-rays, neutrons
A61B 6/12 - Devices for detecting or locating foreign bodies
A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
Biocompatible biomimetic materials that exhibit desirable mechanical properties while also encouraging cell ingrowth and proliferation are described. The biomaterials include a multi-layer laminate of three or more decellularized aligned collagen tissues. The individual layers are aligned with one another in an angle-ply arrangement, with the collagen of each layer aligned at an angle to the collagen of the adjacent layer. The biomaterials are useful as collagenous graft materials such as a patch for a hernia in an annulus fibrosus or grafting materials for repair of tendons, ligaments, cartilage and other musculoskeletal tissues.
A plant propagation system is described that can be utilized for micropropagation through early stages of plant development. A system can include multiple plant support matrices, containers for the matrices, and optionally a tool for separating sections of a plant support matrix from the remainder of the matrix. During use developing plant tissue can be transferred between matrices and growth media can be varied with little or no damage to developing plant tissue and lower chances for contamination of the developing plant tissues.
A system includes a first energy storage device, a second energy storage device coupled to the first energy storage device and charged via a charging current from the first energy storage device, a power controller having a processor, a memory coupled to the processor and on which charging current instructions are stored, and a converter coupled to the processor and directed via switch control signals from the processor, and an output terminal via which power is provided to a load of the system. The converter is disposed between the first energy storage device and the output terminal. The converter is disposed between the first and second energy storage devices and configured to control a level of the charging current in accordance with the switch control signals. The charging current instructions are executed by the processor to cause the processor to generate the switch control signals such that the level of the charging current is regulated.
H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
B60L 11/00 - Electric propulsion with power supplied within the vehicle (B60L 8/00, B60L 13/00 take precedence;arrangements or mounting of prime-movers consisting of electric motors and internal combustion engines for mutual or common propulsion B60K 6/20)
H02J 7/14 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from dynamo-electric generators driven at varying speed, e.g. on vehicle
H02J 7/34 - Parallel operation in networks using both storage and other dc sources, e.g. providing buffering
B60L 1/00 - Supplying electric power to auxiliary equipment of electrically-propelled vehicles
B60L 50/40 - Electric propulsion with power supplied within the vehicle using propulsion power supplied by capacitors
B60L 58/22 - Balancing the charge of battery modules
B60L 58/20 - Methods or circuit arrangements for monitoring or controlling batteries or fuel cells, specially adapted for electric vehicles for monitoring or controlling batteries of two or more battery modules having different nominal voltages
88.
Conotoxin peptides for use in biofouling deterrence
Materials and methods for prevention of biofouling are described that incorporate the presence of a conotoxin peptide on a surface. The conotoxin peptide is either directly or indirectly adhered to the surface and interferes with the ability of biofouling organisms to settle on the surface.
6 or greater and can be formed within a few hours in a surfactant-free environment. The formation process is controlled by initiator-starvation conditions in a sequential polymerization of monomers exhibiting different solubility in the solvent.
C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
C08F 297/02 - Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type
90.
Bi-functional arginine-glycine-aspartic acid (RGD) peptides and methods to promote angiogenesis
The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation and is useful for bioprinting.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
G01N 33/74 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones
Systems and methods for detecting metal clips inserted within a portion of a body of a patient are disclosed herein. In one embodiment, a clip detector assembly includes a detector having a ferrous member, a transmitting coil around the ferrous member and configured to induce a current in the metal clip, and a receiving coil around the ferrous member and configured to receive a magnetic field generated by the current induced in the metal clip. The assembly can further include a control circuit having a band-pass filter configured to pass electrical signals induced by the magnetic field from the receiving coil that are within at most 35 kHz of a resonance frequency of the metal clip. The assembly still further includes a user notification component configured to alert a user to a location of the metal clip.
A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
92.
RADIATION DELIVERY DEVICES AND APPLICATIONS THEREOF
Radiation delivery devices are described herein having compact and lightweight design in comparison to existing architectures. A radiation delivery device comprises a source body including a plurality of radiation sources and a collimator component for directing radiation from the radiation sources to a common focal area, wherein the radiation sources are arranged within the collimator component. In some embodiments, for example, the source body is positioned within an interior cavity of the collimator component.
Described herein are tissues containing semiconductor nanomaterials. In some embodiments, the tissues include vascular cells, cardiomyocytes, and/or cardiac fibroblasts. The tissue may be scaffold-free. In some embodiments, the tissue includes an electrically conductive network. The tissue may exhibit synchronized electrical signal propagation within the tissue. In some embodiments, the tissue exhibits increased functional assembly of cardiac cells and/or increased cardiac specific functions compared to a cardiac tissue prepared using a conventional tissue culture method. Methods of preparing and using such tissues are also described herein.
Chromatography devices and methods for forming and using the devices are described. The devices include a polyamide-based support phase and a polymer grafted to a surface of the polyamide-based support phase. A microwave-assisted graft polymerization protocol is described to form the polymer at the surface of the support phase. Devices can be utilized in high-efficiency separation of macromolecules such as proteins.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
A composite filament for use in additive manufacturing such as fused filament fabrication is described along with methods of its construction and use. The composite filament includes a single continuous filament (e.g., a continuous carbon roving) and a polymer (e.g., a high glass transition polymer) in intimate contact. The composite filament is formed through immersion of the continuous filament in a solution of the polymer. The composite filament can be combined with an additional formation material in an additive manufacturing process.
B29C 67/00 - Shaping techniques not covered by groups , or
B29C 67/24 - Shaping techniques not covered by groups , or characterised by the choice of material
B29C 69/00 - Combinations of shaping techniques not provided for in a single one of main groups , e.g. associations of moulding and joining techniques; Apparatus therefor
96.
Composite continuous filament for additive manufacturing
A composite filament for use in additive manufacturing such as fused filament fabrication is described along with methods of its construction and use. The composite filament includes a single continuous filament (e.g., a continuous carbon roving) and a polymer (e.g., a high glass transition polymer) in intimate contact. The composite filament is formed through immersion of the continuous filament in a solution of the polymer. The composite filament can be combined with an additional formation material in an additive manufacturing process.
B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
B29C 70/30 - Shaping by lay-up, i.e. applying fibres, tape or broadsheet on a mould, former or core; Shaping by spray-up, i.e. spraying of fibres on a mould, former or core
B29B 15/12 - Coating or impregnating of reinforcements of indefinite length
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B33Y 70/00 - Materials specially adapted for additive manufacturing
B29C 64/106 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
B29C 70/20 - Fibrous reinforcements only characterised by the structure of fibrous reinforcements using fibres of substantial or continuous length oriented in a single direction, e.g. roving or other parallel fibres
B29K 105/10 - Condition, form or state of moulded material containing reinforcements, fillers or inserts of continuous length, e.g. cords, rovings, mats, fabrics, strands or yarns oriented
Institute of Organic Chemistry, National Academy of Science of Ukraine (Ukraine)
Inventor
Bliznyuk, Valery N.
Seliman, Ayman F.
Devol, Timothy A.
Derevyanko, Nadezhda A.
Ishchenko, Alexander A.
Abstract
Pyrazoline-based fluorophores and plastic scintillators incorporating the fluorophores are described. The fluorophores include 1,3,5-triaryl substituted pyrazolines. A fluorophore of a plastic scintillator can be a 1-phenyl-4,5-1H-dihydroyrazole having the structure:
2 are independently selected from a heteroaryl group including one or more of an oxygen, selenium or sulfur atom in the ring; an aryl halide group; or a phenyl alkyl including a C1 to C18 saturated or unsaturated alkyl that optionally includes a reactive functionality.
C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
C07D 231/06 - Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
98.
Formation of delivery agents targeted to degraded elastic fibers
Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers. The delivery agents may be utilized for targeted delivery of biologically active compounds to degraded elastic fibers so as to maintain and/or regenerate the elastin component of connective tissue, and prevent further degradation and/or rehabilitate the structural architecture of the connective tissue.
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
Described is an elemental analysis system and methods for use thereof that can be utilized in examination of samples in their native state. The systems utilize a liquid sampling—atmospheric pressure glow discharge (LS-APGD) device for ambient desorption sampling and excitation of a solid sample in combination with optical emission detection. This approach can find application across a broad spectrum of analytical challenges including metals, soils, and volume-limited samples.
G01N 21/67 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence using electric arcs or discharges
G01N 21/69 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids
Rib hook devices, systems, and methods of assembling and using the devices and systems are disclosed. The rib hook device includes a body with a first end and a second end and a rod attachment member coupled to and extending away from the second end of the body. The rib hook system includes at least one rib hook device, a first rod for engaging the at least one rib hook device, and at least one fastener for securing the first rod to the at least one rib hook device. Methods for assembling and using the rib hook devices and systems are also disclosed.
patents
